Details of the Target

General Information of Target

Target ID LDTP10392
Target Name Coiled-coil domain-containing protein 34 (CCDC34)
Gene Name CCDC34
Gene ID 91057
Synonyms
RAMA3; Coiled-coil domain-containing protein 34; Renal carcinoma antigen NY-REN-41
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MKKQRKILWRKGIHLAFSEKWNTGFGGFKKFYFHQHLCILKAKLGRPVTWNRQLRHFQGR
KKALQIQKTWIKDEPLCAKTKFNVATQNVSTLSSKVKRKDAKHFISSSKTLLRLQAEKLL
SSAKNSDHEYCREKNLLKAVTDFPSNSALGQANGHRPRTDPQPSDFPMKFNGESQSPGES
GTIVVTLNNHKRKGFCYGCCQGPEHHRNGGPLIPKKFQLNQHRRIKLSPLMMYEKLSMIR
FRYRILRSQHFRTKSKVCKLRKAQRSWVQKVTGDHQETRRENGEGGSCSPFPSPEPKDPS
CRHQPYFPDMDSSAVVKGTNSHVPDCHTKGSSFLGKELSLDEAFPDQQNGSATNAWDQSS
CSSPKWECTELIHDIPLPEHRSNTMFISETEREIMTLGQENQTSSVSDDRVKLSVSGADT
SVSSVDGPVSQKAVQNENSYQMEEDGSLKQSILSSELLDHPYCKSPLEAPLVCSGLKLEN
QVGGGKNSQKASPVDDEQLSVCLSGFLDEVMKKYGSLVPLSEKEVLGRLKDVFNEDFSNR
KPFINREITNYRARHQKCNFRIFYNKHMLDMDDLATLDGQNWLNDQVINMYGELIMDAVP
DKVHFFNSFFHRQLVTKGYNGVKRWTKKVDLFKKSLLLIPIHLEVHWSLITVTLSNRIIS
FYDSQGIHFKFCVENIRKYLLTEAREKNRPEFLQGWQTAVTKCIPQQKNDSDCGVFVLQY
CKCLALEQPFQFSQEDMPRVRKRIYKELCECRLMD
Target Bioclass
Other
Subcellular location
Cell projection, cilium, flagellum
Function Involved in spermatogenesis. Has a probable role in anterograde intraflagellar transport which is essential for the formation of sperm flagella.
Uniprot ID
Q96HJ3
Ensemble ID
ENST00000317945.6
HGNC ID
HGNC:25079

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
AN3CA SNV: p.R136C .
HEC1 SNV: p.K269R .
NCIH446 SNV: p.K183Ter .
REH SNV: p.A297T .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 3 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
IA-alkyne
 Probe Info  		C248(7.35)  LDD2157  [1]
DBIA
 Probe Info  		C248(1.04)  LDD0531  [2]
IPM
 Probe Info  		N.A.  LDD0147  [3]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HCT 116 C248(1.04)  LDD0531  [2]
 LDCM0215  AC10 HCT 116 C248(1.22)  LDD0532  [2]
 LDCM0226  AC11 HCT 116 C248(1.02)  LDD0543  [2]
 LDCM0237  AC12 HCT 116 C248(0.80)  LDD0554  [2]
 LDCM0259  AC14 HCT 116 C248(1.18)  LDD0576  [2]
 LDCM0270  AC15 HCT 116 C248(1.11)  LDD0587  [2]
 LDCM0279  AC2 HCT 116 C248(1.12)  LDD0596  [2]
 LDCM0280  AC20 HEK-293T C248(0.89)  LDD1519  [4]
 LDCM0283  AC23 HEK-293T C248(1.40)  LDD1522  [4]
 LDCM0288  AC28 HEK-293T C248(1.11)  LDD1527  [4]
 LDCM0290  AC3 HCT 116 C248(1.49)  LDD0607  [2]
 LDCM0292  AC31 HEK-293T C248(1.13)  LDD1531  [4]
 LDCM0297  AC36 HEK-293T C248(0.95)  LDD1536  [4]
 LDCM0300  AC39 HEK-293T C248(1.29)  LDD1539  [4]
 LDCM0301  AC4 HCT 116 C248(1.11)  LDD0618  [2]
 LDCM0306  AC44 HEK-293T C248(0.90)  LDD1545  [4]
 LDCM0309  AC47 HEK-293T C248(1.23)  LDD1548  [4]
 LDCM0312  AC5 HCT 116 C248(1.01)  LDD0629  [2]
 LDCM0315  AC52 HEK-293T C248(1.05)  LDD1554  [4]
 LDCM0318  AC55 HEK-293T C248(1.45)  LDD1557  [4]
 LDCM0320  AC57 HCT 116 C248(1.10)  LDD0637  [2]
 LDCM0321  AC58 HCT 116 C248(1.26)  LDD0638  [2]
 LDCM0322  AC59 HCT 116 C248(2.12)  LDD0639  [2]
 LDCM0323  AC6 HCT 116 C248(1.37)  LDD0640  [2]
 LDCM0324  AC60 HCT 116 C248(1.82)  LDD0641  [2]
 LDCM0325  AC61 HCT 116 C248(2.09)  LDD0642  [2]
 LDCM0326  AC62 HCT 116 C248(1.43)  LDD0643  [2]
 LDCM0327  AC63 HCT 116 C248(1.48)  LDD0644  [2]
 LDCM0328  AC64 HCT 116 C248(1.16)  LDD0645  [2]
 LDCM0329  AC65 HCT 116 C248(1.39)  LDD0646  [2]
 LDCM0330  AC66 HCT 116 C248(1.60)  LDD0647  [2]
 LDCM0331  AC67 HCT 116 C248(1.64)  LDD0648  [2]
 LDCM0334  AC7 HCT 116 C248(1.05)  LDD0651  [2]
 LDCM0345  AC8 HCT 116 C248(0.74)  LDD0662  [2]
 LDCM0248  AKOS034007472 HCT 116 C248(1.02)  LDD0565  [2]
 LDCM0356  AKOS034007680 HCT 116 C248(1.39)  LDD0673  [2]
 LDCM0275  AKOS034007705 HCT 116 C248(0.74)  LDD0592  [2]
 LDCM0369  CL100 HCT 116 C248(1.06)  LDD0686  [2]
 LDCM0370  CL101 HCT 116 C248(0.94)  LDD0687  [2]
 LDCM0371  CL102 HCT 116 C248(0.72)  LDD0688  [2]
 LDCM0372  CL103 HCT 116 C248(0.74)  LDD0689  [2]
 LDCM0373  CL104 HCT 116 C248(0.89)  LDD0690  [2]
 LDCM0375  CL106 HEK-293T C248(1.11)  LDD1579  [4]
 LDCM0377  CL108 HEK-293T C248(1.00)  LDD1581  [4]
 LDCM0379  CL11 HEK-293T C248(1.16)  LDD1583  [4]
 LDCM0380  CL110 HEK-293T C248(1.23)  LDD1584  [4]
 LDCM0382  CL112 HEK-293T C248(1.25)  LDD1586  [4]
 LDCM0384  CL114 HEK-293T C248(0.94)  LDD1588  [4]
 LDCM0386  CL116 HEK-293T C248(0.99)  LDD1590  [4]
 LDCM0388  CL118 HEK-293T C248(1.39)  LDD1592  [4]
 LDCM0391  CL120 HEK-293T C248(0.90)  LDD1595  [4]
 LDCM0393  CL122 HEK-293T C248(1.06)  LDD1597  [4]
 LDCM0395  CL124 HEK-293T C248(1.25)  LDD1599  [4]
 LDCM0396  CL125 HCT 116 C248(1.68)  LDD0713  [2]
 LDCM0397  CL126 HCT 116 C248(1.82)  LDD0714  [2]
 LDCM0398  CL127 HCT 116 C248(1.09)  LDD0715  [2]
 LDCM0399  CL128 HCT 116 C248(1.96)  LDD0716  [2]
 LDCM0401  CL14 HEK-293T C248(1.12)  LDD1605  [4]
 LDCM0403  CL16 HEK-293T C248(1.21)  LDD1607  [4]
 LDCM0407  CL2 HEK-293T C248(0.84)  LDD1611  [4]
 LDCM0408  CL20 HEK-293T C248(0.98)  LDD1612  [4]
 LDCM0411  CL23 HEK-293T C248(1.17)  LDD1615  [4]
 LDCM0414  CL26 HEK-293T C248(1.03)  LDD1618  [4]
 LDCM0416  CL28 HEK-293T C248(1.18)  LDD1620  [4]
 LDCM0420  CL31 HCT 116 C248(0.74)  LDD0737  [2]
 LDCM0421  CL32 HCT 116 C248(0.95)  LDD0738  [2]
 LDCM0422  CL33 HCT 116 C248(0.85)  LDD0739  [2]
 LDCM0423  CL34 HCT 116 C248(1.08)  LDD0740  [2]
 LDCM0424  CL35 HCT 116 C248(0.68)  LDD0741  [2]
 LDCM0425  CL36 HCT 116 C248(0.95)  LDD0742  [2]
 LDCM0426  CL37 HCT 116 C248(0.74)  LDD0743  [2]
 LDCM0428  CL39 HCT 116 C248(0.60)  LDD0745  [2]
 LDCM0429  CL4 HEK-293T C248(1.00)  LDD1633  [4]
 LDCM0430  CL40 HCT 116 C248(0.64)  LDD0747  [2]
 LDCM0431  CL41 HCT 116 C248(0.99)  LDD0748  [2]
 LDCM0432  CL42 HCT 116 C248(0.70)  LDD0749  [2]
 LDCM0433  CL43 HCT 116 C248(0.78)  LDD0750  [2]
 LDCM0434  CL44 HCT 116 C248(0.70)  LDD0751  [2]
 LDCM0435  CL45 HCT 116 C248(0.70)  LDD0752  [2]
 LDCM0436  CL46 HCT 116 C248(1.19)  LDD0753  [2]
 LDCM0437  CL47 HCT 116 C248(1.20)  LDD0754  [2]
 LDCM0438  CL48 HCT 116 C248(1.10)  LDD0755  [2]
 LDCM0439  CL49 HCT 116 C248(0.99)  LDD0756  [2]
 LDCM0441  CL50 HCT 116 C248(0.94)  LDD0758  [2]
 LDCM0442  CL51 HCT 116 C248(1.50)  LDD0759  [2]
 LDCM0443  CL52 HCT 116 C248(1.40)  LDD0760  [2]
 LDCM0444  CL53 HCT 116 C248(0.96)  LDD0761  [2]
 LDCM0445  CL54 HCT 116 C248(1.05)  LDD0762  [2]
 LDCM0446  CL55 HCT 116 C248(1.01)  LDD0763  [2]
 LDCM0447  CL56 HCT 116 C248(1.15)  LDD0764  [2]
 LDCM0448  CL57 HCT 116 C248(1.15)  LDD0765  [2]
 LDCM0449  CL58 HCT 116 C248(1.01)  LDD0766  [2]
 LDCM0450  CL59 HCT 116 C248(1.31)  LDD0767  [2]
 LDCM0452  CL60 HCT 116 C248(1.22)  LDD0769  [2]
 LDCM0454  CL62 HEK-293T C248(0.87)  LDD1657  [4]
 LDCM0456  CL64 HEK-293T C248(0.89)  LDD1659  [4]
 LDCM0460  CL68 HEK-293T C248(1.06)  LDD1663  [4]
 LDCM0464  CL71 HEK-293T C248(1.37)  LDD1667  [4]
 LDCM0467  CL74 HEK-293T C248(0.98)  LDD1670  [4]
 LDCM0469  CL76 HEK-293T C248(1.14)  LDD1672  [4]
 LDCM0473  CL8 HEK-293T C248(0.85)  LDD1676  [4]
 LDCM0474  CL80 HEK-293T C248(1.11)  LDD1677  [4]
 LDCM0477  CL83 HEK-293T C248(1.24)  LDD1680  [4]
 LDCM0480  CL86 HEK-293T C248(0.97)  LDD1683  [4]
 LDCM0482  CL88 HEK-293T C248(1.24)  LDD1685  [4]
 LDCM0486  CL91 HCT 116 C248(1.48)  LDD0803  [2]
 LDCM0487  CL92 HCT 116 C248(1.38)  LDD0804  [2]
 LDCM0488  CL93 HCT 116 C248(0.92)  LDD0805  [2]
 LDCM0489  CL94 HCT 116 C248(0.82)  LDD0806  [2]
 LDCM0490  CL95 HCT 116 C248(1.16)  LDD0807  [2]
 LDCM0491  CL96 HCT 116 C248(1.21)  LDD0808  [2]
 LDCM0492  CL97 HCT 116 C248(1.19)  LDD0809  [2]
 LDCM0493  CL98 HCT 116 C248(1.37)  LDD0810  [2]
 LDCM0494  CL99 HCT 116 C248(1.43)  LDD0811  [2]
 LDCM0427  Fragment51 HCT 116 C248(0.56)  LDD0744  [2]
 LDCM0022  KB02 OV-90 C248(1.51)  LDD2546  [5]
 LDCM0023  KB03 OV-90 C248(1.10)  LDD2963  [5]
 LDCM0024  KB05 OV-90 C248(1.58)  LDD3380  [5]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 3 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Histone acetyltransferase KAT5 (KAT5) MYST (SAS/MOZ) family Q92993
Atypical kinase COQ8A, mitochondrial (COQ8A) ADCK protein kinase family Q8NI60
Lysoplasmalogenase TMEM86B (TMEM86B) TMEM86 family Q8N661
Transporter and channel
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
14-3-3 protein gamma (YWHAG) 14-3-3 family P61981

References

1 From chemoproteomic-detected amino acids to genomic coordinates: insights into precise multi-omic data integration. Mol Syst Biol. 2021 Feb;17(2):e9840. doi: 10.15252/msb.20209840.
Mass spectrometry data entry: PXD022151
2 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
3 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
4 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
5 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840