Details of the Target

General Information of Target

Target ID LDTP10270
Target Name E3 ubiquitin-protein ligase CHFR (CHFR)
Gene Name CHFR
Gene ID 55743
Synonyms
RNF196; E3 ubiquitin-protein ligase CHFR; EC 2.3.2.27; Checkpoint with forkhead and RING finger domains protein; RING finger protein 196; RING-type E3 ubiquitin transferase CHFR
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MPGEEEERAFLVAREELASALRRDSGQAFSLEQLRPLLASSLPLAARYLQLDAARLVRCN
AHGEPRNYLNTLSTALNILEKYGRNLLSPQRPRYWRGVKFNNPVFRSTVDAVQGGRDVLR
LYGYTEEQPDGLSFPEGQEEPDEHQVATVTLEVLLLRTELSLLLQNTHPRQQALEQLLED
KVEDDMLQLSEFDPLLREIAPGPLTTPSVPGSTPGPCFLCGSAPGTLHCPSCKQALCPAC
DHLFHGHPSRAHHLRQTLPGVLQGTHLSPSLPASAQPRPQSTSLLALGDSSLSSPNPASA
HLPWHCAACAMLNEPWAVLCVACDRPRGCKGLGLGTEGPQGTGGLEPDLARGRWACQSCT
FENEAAAVLCSICERPRLAQPPSLVVDSRDAGICLQPLQQGDALLASAQSQVWYCIHCTF
CNSSPGWVCVMCNRTSSPIPAQHAPRPYASSLEKGPPKPGPPRRLSAPLPSSCGDPEKQR
QDKMREEGLQLVSMIREGEAAGACPEEIFSALQYSGTEVPLQWLRSELPYVLEMVAELAG
QQDPGLGAFSCQEARRAWLDRHGNLDEAVEECVRTRRRKVQELQSLGFGPEEGSLQALFQ
HGGDVSRALTELQRQRLEPFRQRLWDSGPEPTPSWDGPDKQSLVRRLLAVYALPSWGRAE
LALSLLQETPRNYELGDVVEAVRHSQDRAFLRRLLAQECAVCGWALPHNRMQALTSCECT
ICPDCFRQHFTIALKEKHITDMVCPACGRPDLTDDTQLLSYFSTLDIQLRESLEPDAYAL
FHKKLTEGVLMRDPKFLWCAQCSFGFIYEREQLEATCPQCHQTFCVRCKRQWEEQHRGRS
CEDFQNWKRMNDPEYQAQGLAMYLQENGIDCPKCKFSYALARGGCMHFHCTQCRHQFCSG
CYNAFYAKNKCPEPNCRVKKSLHGHHPRDCLFYLRDWTALRLQKLLQDNNVMFNTEPPAG
ARAVPGGGCRVIEQKEVPNGLRDEACGKETPAGYAGLCQAHYKEYLVSLINAHSLDPATL
YEVEELETATERYLHVRPQPLAGEDPPAYQARLLQKLTEEVPLGQSIPRRRK
Target Bioclass
Enzyme
Family
CHFR family
Subcellular location
Nucleus, PML body
Function
E3 ubiquitin-protein ligase that functions in the antephase checkpoint by actively delaying passage into mitosis in response to microtubule poisons. Acts in early prophase before chromosome condensation, when the centrosome move apart from each other along the periphery of the nucleus. Probably involved in signaling the presence of mitotic stress caused by microtubule poisons by mediating the 'Lys-48'-linked ubiquitination of target proteins, leading to their degradation by the proteasome. Promotes the ubiquitination and subsequent degradation of AURKA and PLK1. Probably acts as a tumor suppressor, possibly by mediating the polyubiquitination of HDAC1, leading to its degradation. May also promote the formation of 'Lys-63'-linked polyubiquitin chains and functions with the specific ubiquitin-conjugating UBC13-MMS2 (UBE2N-UBE2V2) heterodimer. Substrates that are polyubiquitinated at 'Lys-63' are usually not targeted for degradation, but are rather involved in signaling cellular stress.
Uniprot ID
Q96EP1
Ensemble ID
ENST00000266880.11
HGNC ID
HGNC:20455

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 3 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
IPM
 Probe Info  		N.A.  LDD0241  [1]
DBIA
 Probe Info  		C601(0.88); C603(0.88); C604(0.88)  LDD0078  [2]
IA-alkyne
 Probe Info  		N.A.  LDD0165  [3]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 PaTu 8988t C537(1.85); C529(1.85); C532(1.85)  LDD1093  [2]
 LDCM0215  AC10 HEK-293T C657(1.09); C545(1.10)  LDD1508  [4]
 LDCM0216  AC100 PaTu 8988t C537(1.09); C529(1.09); C532(1.09)  LDD1095  [2]
 LDCM0217  AC101 PaTu 8988t C537(1.17); C529(1.17); C532(1.17)  LDD1096  [2]
 LDCM0218  AC102 PaTu 8988t C537(0.89); C529(0.89); C532(0.89)  LDD1097  [2]
 LDCM0219  AC103 PaTu 8988t C537(1.27); C529(1.27); C532(1.27)  LDD1098  [2]
 LDCM0220  AC104 PaTu 8988t C537(1.03); C529(1.03); C532(1.03)  LDD1099  [2]
 LDCM0221  AC105 PaTu 8988t C537(0.94); C529(0.94); C532(0.94)  LDD1100  [2]
 LDCM0222  AC106 PaTu 8988t C537(1.11); C529(1.11); C532(1.11)  LDD1101  [2]
 LDCM0223  AC107 PaTu 8988t C537(1.63); C529(1.63); C532(1.63)  LDD1102  [2]
 LDCM0224  AC108 PaTu 8988t C537(1.08); C529(1.08); C532(1.08)  LDD1103  [2]
 LDCM0225  AC109 PaTu 8988t C537(1.12); C529(1.12); C532(1.12)  LDD1104  [2]
 LDCM0227  AC110 PaTu 8988t C537(1.08); C529(1.08); C532(1.08)  LDD1106  [2]
 LDCM0228  AC111 PaTu 8988t C537(1.06); C529(1.06); C532(1.06)  LDD1107  [2]
 LDCM0229  AC112 PaTu 8988t C537(1.08); C529(1.08); C532(1.08)  LDD1108  [2]
 LDCM0237  AC12 HEK-293T C657(0.98)  LDD1510  [4]
 LDCM0246  AC128 PaTu 8988t C537(1.26); C532(1.26)  LDD1125  [2]
 LDCM0247  AC129 PaTu 8988t C537(1.18); C532(1.18)  LDD1126  [2]
 LDCM0249  AC130 PaTu 8988t C537(1.29); C532(1.29)  LDD1128  [2]
 LDCM0250  AC131 PaTu 8988t C537(1.45); C532(1.45)  LDD1129  [2]
 LDCM0251  AC132 PaTu 8988t C537(1.25); C532(1.25)  LDD1130  [2]
 LDCM0252  AC133 PaTu 8988t C537(1.17); C532(1.17)  LDD1131  [2]
 LDCM0253  AC134 PaTu 8988t C537(1.16); C532(1.16)  LDD1132  [2]
 LDCM0254  AC135 PaTu 8988t C537(1.11); C532(1.11)  LDD1133  [2]
 LDCM0255  AC136 PaTu 8988t C537(1.27); C532(1.27)  LDD1134  [2]
 LDCM0256  AC137 PaTu 8988t C537(1.33); C532(1.33)  LDD1135  [2]
 LDCM0257  AC138 PaTu 8988t C537(1.37); C532(1.37)  LDD1136  [2]
 LDCM0258  AC139 PaTu 8988t C537(1.44); C532(1.44)  LDD1137  [2]
 LDCM0259  AC14 HEK-293T C657(1.05)  LDD1512  [4]
 LDCM0260  AC140 PaTu 8988t C537(1.54); C532(1.54)  LDD1139  [2]
 LDCM0261  AC141 PaTu 8988t C537(1.23); C532(1.23)  LDD1140  [2]
 LDCM0262  AC142 PaTu 8988t C537(1.23); C532(1.23)  LDD1141  [2]
 LDCM0263  AC143 PaTu 8988t C529(1.62); C532(1.62)  LDD1142  [2]
 LDCM0264  AC144 PaTu 8988t C529(1.52); C532(1.52)  LDD1143  [2]
 LDCM0265  AC145 PaTu 8988t C529(0.91); C532(0.91)  LDD1144  [2]
 LDCM0266  AC146 PaTu 8988t C529(1.08); C532(1.08)  LDD1145  [2]
 LDCM0267  AC147 PaTu 8988t C529(1.12); C532(1.12)  LDD1146  [2]
 LDCM0268  AC148 PaTu 8988t C529(1.21); C532(1.21)  LDD1147  [2]
 LDCM0269  AC149 PaTu 8988t C529(1.46); C532(1.46)  LDD1148  [2]
 LDCM0270  AC15 HEK-293T C657(1.08)  LDD1513  [4]
 LDCM0271  AC150 PaTu 8988t C529(1.23); C532(1.23)  LDD1150  [2]
 LDCM0272  AC151 PaTu 8988t C529(1.52); C532(1.52)  LDD1151  [2]
 LDCM0273  AC152 PaTu 8988t C529(1.59); C532(1.59)  LDD1152  [2]
 LDCM0274  AC153 PaTu 8988t C529(1.35); C532(1.35)  LDD1153  [2]
 LDCM0621  AC154 PaTu 8988t C529(1.24); C532(1.24)  LDD2166  [2]
 LDCM0622  AC155 PaTu 8988t C529(1.24); C532(1.24)  LDD2167  [2]
 LDCM0623  AC156 PaTu 8988t C529(1.47); C532(1.47)  LDD2168  [2]
 LDCM0624  AC157 PaTu 8988t C529(1.14); C532(1.14)  LDD2169  [2]
 LDCM0276  AC17 PaTu 8988t C532(0.72)  LDD1155  [2]
 LDCM0277  AC18 PaTu 8988t C532(1.21)  LDD1156  [2]
 LDCM0278  AC19 PaTu 8988t C532(1.06)  LDD1157  [2]
 LDCM0279  AC2 PaTu 8988t C537(1.42); C529(1.42); C532(1.42)  LDD1158  [2]
 LDCM0280  AC20 PaTu 8988t C532(0.93)  LDD1159  [2]
 LDCM0281  AC21 PaTu 8988t C532(1.06)  LDD1160  [2]
 LDCM0282  AC22 PaTu 8988t C532(0.87)  LDD1161  [2]
 LDCM0283  AC23 PaTu 8988t C532(1.03)  LDD1162  [2]
 LDCM0284  AC24 PaTu 8988t C532(1.23)  LDD1163  [2]
 LDCM0285  AC25 PaTu 8988t C529(1.23); C532(1.23)  LDD1164  [2]
 LDCM0286  AC26 PaTu 8988t C529(1.28); C532(1.28)  LDD1165  [2]
 LDCM0287  AC27 PaTu 8988t C529(1.44); C532(1.44)  LDD1166  [2]
 LDCM0288  AC28 PaTu 8988t C529(1.52); C532(1.52)  LDD1167  [2]
 LDCM0289  AC29 PaTu 8988t C529(1.31); C532(1.31)  LDD1168  [2]
 LDCM0290  AC3 PaTu 8988t C537(1.27); C529(1.27); C532(1.27)  LDD1169  [2]
 LDCM0291  AC30 PaTu 8988t C529(1.20); C532(1.20)  LDD1170  [2]
 LDCM0292  AC31 PaTu 8988t C529(1.10); C532(1.10)  LDD1171  [2]
 LDCM0293  AC32 PaTu 8988t C529(0.87); C532(0.87)  LDD1172  [2]
 LDCM0294  AC33 PaTu 8988t C529(1.70); C532(1.70)  LDD1173  [2]
 LDCM0295  AC34 PaTu 8988t C529(1.20); C532(1.20)  LDD1174  [2]
 LDCM0296  AC35 PaTu 8988t C529(1.10); C532(1.10)  LDD1175  [2]
 LDCM0297  AC36 PaTu 8988t C529(1.14); C532(1.14)  LDD1176  [2]
 LDCM0298  AC37 PaTu 8988t C529(1.45); C532(1.45)  LDD1177  [2]
 LDCM0299  AC38 PaTu 8988t C529(1.29); C532(1.29)  LDD1178  [2]
 LDCM0300  AC39 PaTu 8988t C529(1.32); C532(1.32)  LDD1179  [2]
 LDCM0301  AC4 PaTu 8988t C537(1.32); C529(1.32); C532(1.32)  LDD1180  [2]
 LDCM0302  AC40 PaTu 8988t C529(1.19); C532(1.19)  LDD1181  [2]
 LDCM0303  AC41 PaTu 8988t C529(1.21); C532(1.21)  LDD1182  [2]
 LDCM0304  AC42 PaTu 8988t C529(1.42); C532(1.42)  LDD1183  [2]
 LDCM0305  AC43 PaTu 8988t C529(1.47); C532(1.47)  LDD1184  [2]
 LDCM0306  AC44 PaTu 8988t C529(1.81); C532(1.81)  LDD1185  [2]
 LDCM0307  AC45 PaTu 8988t C529(1.23); C532(1.23)  LDD1186  [2]
 LDCM0308  AC46 PaTu 8988t C537(1.20); C532(1.20)  LDD1187  [2]
 LDCM0309  AC47 PaTu 8988t C537(1.48); C532(1.48)  LDD1188  [2]
 LDCM0310  AC48 PaTu 8988t C537(1.37); C532(1.37)  LDD1189  [2]
 LDCM0311  AC49 PaTu 8988t C537(1.21); C532(1.21)  LDD1190  [2]
 LDCM0312  AC5 PaTu 8988t C537(1.82); C529(1.82); C532(1.82)  LDD1191  [2]
 LDCM0313  AC50 PaTu 8988t C537(1.78); C532(1.78)  LDD1192  [2]
 LDCM0314  AC51 PaTu 8988t C537(1.15); C532(1.15)  LDD1193  [2]
 LDCM0315  AC52 PaTu 8988t C537(1.21); C532(1.21)  LDD1194  [2]
 LDCM0316  AC53 PaTu 8988t C537(1.42); C532(1.42)  LDD1195  [2]
 LDCM0317  AC54 PaTu 8988t C537(1.57); C532(1.57)  LDD1196  [2]
 LDCM0318  AC55 PaTu 8988t C537(1.34); C532(1.34)  LDD1197  [2]
 LDCM0319  AC56 PaTu 8988t C537(1.33); C532(1.33)  LDD1198  [2]
 LDCM0320  AC57 HEK-293T C545(1.02)  LDD1559  [4]
 LDCM0321  AC58 HEK-293T C657(1.02); C545(1.03)  LDD1560  [4]
 LDCM0323  AC6 HEK-293T C657(1.05)  LDD1562  [4]
 LDCM0324  AC60 HEK-293T C657(1.03)  LDD1563  [4]
 LDCM0326  AC62 HEK-293T C657(1.00)  LDD1565  [4]
 LDCM0327  AC63 HEK-293T C657(1.06)  LDD1566  [4]
 LDCM0328  AC64 HEK-293T C657(0.96)  LDD1567  [4]
 LDCM0332  AC68 PaTu 8988t C537(0.79); C529(1.03); C532(1.02)  LDD1211  [2]
 LDCM0333  AC69 PaTu 8988t C537(0.77); C529(1.01); C532(0.98)  LDD1212  [2]
 LDCM0334  AC7 HEK-293T C657(0.99)  LDD1568  [4]
 LDCM0335  AC70 PaTu 8988t C537(1.11); C529(1.08); C532(1.15)  LDD1214  [2]
 LDCM0336  AC71 PaTu 8988t C537(0.77); C529(1.03); C532(0.96)  LDD1215  [2]
 LDCM0337  AC72 PaTu 8988t C537(0.61); C529(1.00); C532(0.95)  LDD1216  [2]
 LDCM0338  AC73 PaTu 8988t C537(0.68); C529(0.95); C532(0.93)  LDD1217  [2]
 LDCM0339  AC74 PaTu 8988t C537(0.73); C529(0.90); C532(0.91)  LDD1218  [2]
 LDCM0340  AC75 PaTu 8988t C537(0.87); C529(1.31); C532(1.25)  LDD1219  [2]
 LDCM0341  AC76 PaTu 8988t C537(0.61); C529(1.17); C532(1.07)  LDD1220  [2]
 LDCM0342  AC77 PaTu 8988t C537(1.02); C529(1.00); C532(1.05)  LDD1221  [2]
 LDCM0343  AC78 PaTu 8988t C537(0.74); C529(0.92); C532(0.93)  LDD1222  [2]
 LDCM0344  AC79 PaTu 8988t C537(0.83); C529(1.25); C532(1.26)  LDD1223  [2]
 LDCM0345  AC8 HEK-293T C657(1.07)  LDD1569  [4]
 LDCM0346  AC80 PaTu 8988t C537(0.70); C529(1.05); C532(1.00)  LDD1225  [2]
 LDCM0347  AC81 PaTu 8988t C537(0.74); C529(1.01); C532(0.99)  LDD1226  [2]
 LDCM0348  AC82 PaTu 8988t C537(0.87); C529(1.12); C532(1.14)  LDD1227  [2]
 LDCM0349  AC83 PaTu 8988t C537(1.19); C529(1.19); C532(1.19)  LDD1228  [2]
 LDCM0350  AC84 PaTu 8988t C537(0.98); C529(0.98); C532(0.98)  LDD1229  [2]
 LDCM0351  AC85 PaTu 8988t C537(1.14); C529(1.14); C532(1.14)  LDD1230  [2]
 LDCM0352  AC86 PaTu 8988t C537(1.37); C529(1.37); C532(1.37)  LDD1231  [2]
 LDCM0353  AC87 PaTu 8988t C537(1.16); C529(1.16); C532(1.16)  LDD1232  [2]
 LDCM0354  AC88 PaTu 8988t C537(1.06); C529(1.06); C532(1.06)  LDD1233  [2]
 LDCM0355  AC89 PaTu 8988t C537(0.95); C529(0.95); C532(0.95)  LDD1234  [2]
 LDCM0357  AC90 PaTu 8988t C537(0.92); C529(0.92); C532(0.92)  LDD1236  [2]
 LDCM0358  AC91 PaTu 8988t C537(1.19); C529(1.19); C532(1.19)  LDD1237  [2]
 LDCM0359  AC92 PaTu 8988t C537(0.98); C529(0.98); C532(0.98)  LDD1238  [2]
 LDCM0360  AC93 PaTu 8988t C537(0.89); C529(0.89); C532(0.89)  LDD1239  [2]
 LDCM0361  AC94 PaTu 8988t C537(0.99); C529(0.99); C532(0.99)  LDD1240  [2]
 LDCM0362  AC95 PaTu 8988t C537(1.17); C529(1.17); C532(1.17)  LDD1241  [2]
 LDCM0363  AC96 PaTu 8988t C537(1.09); C529(1.09); C532(1.09)  LDD1242  [2]
 LDCM0364  AC97 PaTu 8988t C537(0.83); C529(0.83); C532(0.83)  LDD1243  [2]
 LDCM0365  AC98 PaTu 8988t C537(1.08); C529(1.08); C532(1.08)  LDD1244  [2]
 LDCM0366  AC99 PaTu 8988t C537(0.98); C529(0.98); C532(0.98)  LDD1245  [2]
 LDCM0356  AKOS034007680 HEK-293T C545(1.10)  LDD1570  [4]
 LDCM0275  AKOS034007705 HEK-293T C657(0.92)  LDD1514  [4]
 LDCM0020  ARS-1620 HCC44 C601(0.88); C603(0.88); C604(0.88)  LDD0078  [2]
 LDCM0367  CL1 HEK-293T C657(0.97)  LDD1571  [4]
 LDCM0368  CL10 HEK-293T C657(1.25)  LDD1572  [4]
 LDCM0369  CL100 PaTu 8988t C537(1.30); C529(1.30); C532(1.30)  LDD1248  [2]
 LDCM0370  CL101 HEK-293T C657(1.06)  LDD1574  [4]
 LDCM0371  CL102 HEK-293T C657(0.86); C545(1.22)  LDD1575  [4]
 LDCM0373  CL104 HEK-293T C657(1.05)  LDD1577  [4]
 LDCM0374  CL105 PaTu 8988t C532(1.13)  LDD1253  [2]
 LDCM0375  CL106 PaTu 8988t C532(0.78)  LDD1254  [2]
 LDCM0376  CL107 PaTu 8988t C532(1.52)  LDD1255  [2]
 LDCM0377  CL108 PaTu 8988t C532(0.94)  LDD1256  [2]
 LDCM0378  CL109 PaTu 8988t C532(1.07)  LDD1257  [2]
 LDCM0379  CL11 HEK-293T C657(1.08)  LDD1583  [4]
 LDCM0380  CL110 PaTu 8988t C532(0.93)  LDD1259  [2]
 LDCM0381  CL111 PaTu 8988t C532(1.22)  LDD1260  [2]
 LDCM0382  CL112 PaTu 8988t C529(1.19); C532(1.19)  LDD1261  [2]
 LDCM0383  CL113 PaTu 8988t C529(1.15); C532(1.15)  LDD1262  [2]
 LDCM0384  CL114 PaTu 8988t C529(1.36); C532(1.36)  LDD1263  [2]
 LDCM0385  CL115 PaTu 8988t C529(1.22); C532(1.22)  LDD1264  [2]
 LDCM0386  CL116 PaTu 8988t C529(1.53); C532(1.53)  LDD1265  [2]
 LDCM0387  CL117 PaTu 8988t C529(1.00); C532(1.00)  LDD1266  [2]
 LDCM0388  CL118 PaTu 8988t C529(1.14); C532(1.14)  LDD1267  [2]
 LDCM0389  CL119 PaTu 8988t C529(1.33); C532(1.33)  LDD1268  [2]
 LDCM0390  CL12 HEK-293T C657(1.06)  LDD1594  [4]
 LDCM0391  CL120 PaTu 8988t C529(1.06); C532(1.06)  LDD1270  [2]
 LDCM0392  CL121 PaTu 8988t C537(1.20); C532(1.20)  LDD1271  [2]
 LDCM0393  CL122 PaTu 8988t C537(1.84); C532(1.84)  LDD1272  [2]
 LDCM0394  CL123 PaTu 8988t C537(1.21); C532(1.21)  LDD1273  [2]
 LDCM0395  CL124 PaTu 8988t C537(1.14); C532(1.14)  LDD1274  [2]
 LDCM0396  CL125 HEK-293T C657(1.06)  LDD1600  [4]
 LDCM0397  CL126 HEK-293T C657(0.94); C545(1.16)  LDD1601  [4]
 LDCM0399  CL128 HEK-293T C657(0.94)  LDD1603  [4]
 LDCM0400  CL13 HEK-293T C657(1.11)  LDD1604  [4]
 LDCM0401  CL14 HEK-293T C657(0.86); C545(1.35)  LDD1605  [4]
 LDCM0403  CL16 HEK-293T C657(1.06)  LDD1607  [4]
 LDCM0404  CL17 HEK-293T C545(0.89)  LDD1608  [4]
 LDCM0405  CL18 HEK-293T C657(1.16); C545(1.10)  LDD1609  [4]
 LDCM0407  CL2 HEK-293T C657(0.97); C545(1.31)  LDD1611  [4]
 LDCM0408  CL20 HEK-293T C657(1.09)  LDD1612  [4]
 LDCM0410  CL22 HEK-293T C657(1.39)  LDD1614  [4]
 LDCM0411  CL23 HEK-293T C657(1.20)  LDD1615  [4]
 LDCM0412  CL24 HEK-293T C657(1.07)  LDD1616  [4]
 LDCM0413  CL25 HEK-293T C657(1.02)  LDD1617  [4]
 LDCM0414  CL26 HEK-293T C657(1.06); C545(1.37)  LDD1618  [4]
 LDCM0416  CL28 HEK-293T C657(0.97)  LDD1620  [4]
 LDCM0417  CL29 HEK-293T C545(0.92)  LDD1621  [4]
 LDCM0419  CL30 HEK-293T C657(1.08); C545(0.95)  LDD1623  [4]
 LDCM0421  CL32 HEK-293T C657(1.19)  LDD1625  [4]
 LDCM0423  CL34 HEK-293T C657(1.32)  LDD1627  [4]
 LDCM0424  CL35 HEK-293T C657(1.22)  LDD1628  [4]
 LDCM0425  CL36 HEK-293T C657(1.07)  LDD1629  [4]
 LDCM0426  CL37 HEK-293T C657(1.04)  LDD1630  [4]
 LDCM0429  CL4 HEK-293T C657(1.15)  LDD1633  [4]
 LDCM0430  CL40 HEK-293T C657(1.09)  LDD1634  [4]
 LDCM0431  CL41 HEK-293T C545(1.20)  LDD1635  [4]
 LDCM0432  CL42 HEK-293T C657(1.34); C545(1.04)  LDD1636  [4]
 LDCM0434  CL44 HEK-293T C657(1.19)  LDD1638  [4]
 LDCM0436  CL46 HEK-293T C657(1.45)  LDD1640  [4]
 LDCM0437  CL47 HEK-293T C657(1.16)  LDD1641  [4]
 LDCM0438  CL48 HEK-293T C657(1.03)  LDD1642  [4]
 LDCM0439  CL49 HEK-293T C657(1.07)  LDD1643  [4]
 LDCM0440  CL5 HEK-293T C545(1.04)  LDD1644  [4]
 LDCM0441  CL50 HEK-293T C657(0.85); C545(1.24)  LDD1645  [4]
 LDCM0443  CL52 HEK-293T C657(1.10)  LDD1646  [4]
 LDCM0444  CL53 HEK-293T C545(1.01)  LDD1647  [4]
 LDCM0445  CL54 HEK-293T C657(1.03); C545(0.90)  LDD1648  [4]
 LDCM0447  CL56 HEK-293T C657(1.18)  LDD1650  [4]
 LDCM0449  CL58 HEK-293T C657(1.39)  LDD1652  [4]
 LDCM0450  CL59 HEK-293T C657(1.21)  LDD1653  [4]
 LDCM0451  CL6 HEK-293T C657(1.09); C545(1.02)  LDD1654  [4]
 LDCM0452  CL60 HEK-293T C657(1.25)  LDD1655  [4]
 LDCM0453  CL61 HEK-293T C657(1.01)  LDD1656  [4]
 LDCM0454  CL62 HEK-293T C657(1.06); C545(1.44)  LDD1657  [4]
 LDCM0456  CL64 HEK-293T C657(1.06)  LDD1659  [4]
 LDCM0457  CL65 HEK-293T C545(1.23)  LDD1660  [4]
 LDCM0458  CL66 HEK-293T C657(1.21); C545(1.16)  LDD1661  [4]
 LDCM0460  CL68 HEK-293T C657(1.16)  LDD1663  [4]
 LDCM0463  CL70 HEK-293T C657(1.28)  LDD1666  [4]
 LDCM0464  CL71 HEK-293T C657(1.20)  LDD1667  [4]
 LDCM0465  CL72 HEK-293T C657(1.14)  LDD1668  [4]
 LDCM0466  CL73 HEK-293T C657(0.93)  LDD1669  [4]
 LDCM0467  CL74 HEK-293T C657(1.01); C545(1.15)  LDD1670  [4]
 LDCM0469  CL76 HEK-293T C657(1.02)  LDD1672  [4]
 LDCM0470  CL77 HEK-293T C545(1.17)  LDD1673  [4]
 LDCM0471  CL78 HEK-293T C657(1.23); C545(0.94)  LDD1674  [4]
 LDCM0473  CL8 HEK-293T C657(0.92)  LDD1676  [4]
 LDCM0474  CL80 HEK-293T C657(1.13)  LDD1677  [4]
 LDCM0476  CL82 HEK-293T C657(1.30)  LDD1679  [4]
 LDCM0477  CL83 HEK-293T C657(1.05)  LDD1680  [4]
 LDCM0478  CL84 HEK-293T C657(1.08)  LDD1681  [4]
 LDCM0479  CL85 HEK-293T C657(1.09)  LDD1682  [4]
 LDCM0480  CL86 HEK-293T C657(0.97); C545(1.37)  LDD1683  [4]
 LDCM0482  CL88 HEK-293T C657(1.02)  LDD1685  [4]
 LDCM0483  CL89 HEK-293T C545(1.10)  LDD1686  [4]
 LDCM0485  CL90 HEK-293T C657(1.04); C545(1.08)  LDD1688  [4]
 LDCM0486  CL91 PaTu 8988t C537(1.09); C529(1.09); C532(1.09)  LDD1365  [2]
 LDCM0487  CL92 PaTu 8988t C537(1.54); C529(1.54); C532(1.54)  LDD1366  [2]
 LDCM0488  CL93 PaTu 8988t C537(1.30); C529(1.30); C532(1.30)  LDD1367  [2]
 LDCM0489  CL94 PaTu 8988t C537(1.35); C529(1.35); C532(1.35)  LDD1368  [2]
 LDCM0490  CL95 PaTu 8988t C537(2.22); C529(2.22); C532(2.22)  LDD1369  [2]
 LDCM0491  CL96 PaTu 8988t C537(1.57); C529(1.57); C532(1.57)  LDD1370  [2]
 LDCM0492  CL97 PaTu 8988t C537(1.42); C529(1.42); C532(1.42)  LDD1371  [2]
 LDCM0493  CL98 PaTu 8988t C537(1.95); C529(1.95); C532(1.95)  LDD1372  [2]
 LDCM0494  CL99 PaTu 8988t C537(1.45); C529(1.45); C532(1.45)  LDD1373  [2]
 LDCM0427  Fragment51 HEK-293T C657(1.13); C545(1.20)  LDD1631  [4]
 LDCM0022  KB02 HCT 116 C529(7.41); C537(7.41); C532(7.41); C635(1.48)  LDD0080  [2]
 LDCM0023  KB03 HCT 116 C529(6.33); C537(6.33); C532(6.33); C635(1.71)  LDD0081  [2]
 LDCM0024  KB05 HCT 116 C529(2.68); C537(2.68); C532(2.68); C635(1.06)  LDD0082  [2]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 4 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Ubiquitin-conjugating enzyme E2 D1 (UBE2D1) Ubiquitin-conjugating enzyme family P51668
Ubiquitin-conjugating enzyme E2 D2 (UBE2D2) Ubiquitin-conjugating enzyme family P62837
Ubiquitin-conjugating enzyme E2 E2 (UBE2E2) Ubiquitin-conjugating enzyme family Q96LR5
Ubiquitin-conjugating enzyme E2 E3 (UBE2E3) Ubiquitin-conjugating enzyme family Q969T4

References

1 Oxidant-Induced Bioconjugation for Protein Labeling in Live Cells. ACS Chem Biol. 2023 Jan 20;18(1):112-122. doi: 10.1021/acschembio.2c00740. Epub 2022 Dec 21.
2 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
3 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
4 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402