Details of the Target

General Information of Target

Target ID LDTP10138
Target Name Zinc finger protein 669 (ZNF669)
Gene Name ZNF669
Gene ID 79862
Synonyms
Zinc finger protein 669
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MAGMVDFQDEEQVKSFLENMEVECNYHCYHEKDPDGCYRLVDYLEGIRKNFDEAAKVLKF
NCEENQHSDSCYKLGAYYVTGKGGLTQDLKAAARCFLMACEKPGKKSIAACHNVGLLAHD
GQVNEDGQPDLGKARDYYTRACDGGYTSSCFNLSAMFLQGAPGFPKDMDLACKYSMKACD
LGHIWACANASRMYKLGDGVDKDEAKAEVLKNRAQQLHKEQQKGVQPLTFG
Target Bioclass
Transcription factor
Family
Krueppel C2H2-type zinc-finger protein family
Subcellular location
Nucleus
Function May be involved in transcriptional regulation.
Uniprot ID
Q96BR6
Ensemble ID
ENST00000343381.10
HGNC ID
HGNC:25736

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 3 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
AHL-Pu-1
 Probe Info  		C308(2.31)  LDD0170  [1]
DBIA
 Probe Info  		C345(0.93)  LDD0531  [2]
HHS-465
 Probe Info  		K276(0.00); K279(0.00); Y278(0.00)  LDD2240  [3]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0025  4SU-RNA DM93 C308(2.31)  LDD0170  [1]
 LDCM0026  4SU-RNA+native RNA DM93 C308(2.25)  LDD0171  [1]
 LDCM0214  AC1 HCT 116 C345(0.93)  LDD0531  [2]
 LDCM0215  AC10 HCT 116 C345(1.86)  LDD0532  [2]
 LDCM0216  AC100 HCT 116 C345(0.79)  LDD0533  [2]
 LDCM0217  AC101 HCT 116 C345(0.92)  LDD0534  [2]
 LDCM0218  AC102 HCT 116 C345(1.01)  LDD0535  [2]
 LDCM0219  AC103 HCT 116 C345(1.24)  LDD0536  [2]
 LDCM0220  AC104 HCT 116 C345(0.90)  LDD0537  [2]
 LDCM0221  AC105 HCT 116 C345(0.84)  LDD0538  [2]
 LDCM0222  AC106 HCT 116 C345(1.17)  LDD0539  [2]
 LDCM0223  AC107 HCT 116 C345(0.91)  LDD0540  [2]
 LDCM0224  AC108 HCT 116 C345(0.82)  LDD0541  [2]
 LDCM0225  AC109 HCT 116 C345(0.67)  LDD0542  [2]
 LDCM0226  AC11 HCT 116 C345(1.39)  LDD0543  [2]
 LDCM0227  AC110 HCT 116 C345(0.82)  LDD0544  [2]
 LDCM0228  AC111 HCT 116 C345(0.78)  LDD0545  [2]
 LDCM0229  AC112 HCT 116 C345(0.92)  LDD0546  [2]
 LDCM0237  AC12 HCT 116 C345(1.25)  LDD0554  [2]
 LDCM0259  AC14 HCT 116 C345(1.79)  LDD0576  [2]
 LDCM0270  AC15 HCT 116 C345(2.05)  LDD0587  [2]
 LDCM0277  AC18 HEK-293T C293(0.83)  LDD1516  [4]
 LDCM0279  AC2 HCT 116 C345(1.07)  LDD0596  [2]
 LDCM0284  AC24 HEK-293T C293(1.04)  LDD1523  [4]
 LDCM0286  AC26 HEK-293T C293(0.96)  LDD1525  [4]
 LDCM0290  AC3 HCT 116 C345(0.84)  LDD0607  [2]
 LDCM0293  AC32 HEK-293T C293(1.07)  LDD1532  [4]
 LDCM0295  AC34 HEK-293T C293(0.93)  LDD1534  [4]
 LDCM0301  AC4 HCT 116 C345(1.06)  LDD0618  [2]
 LDCM0302  AC40 HEK-293T C293(1.01)  LDD1541  [4]
 LDCM0304  AC42 HEK-293T C293(1.09)  LDD1543  [4]
 LDCM0310  AC48 HEK-293T C293(1.05)  LDD1549  [4]
 LDCM0312  AC5 HCT 116 C345(1.01)  LDD0629  [2]
 LDCM0313  AC50 HEK-293T C293(1.11)  LDD1552  [4]
 LDCM0319  AC56 HEK-293T C293(0.99)  LDD1558  [4]
 LDCM0321  AC58 HEK-293T C293(0.97)  LDD1560  [4]
 LDCM0323  AC6 HCT 116 C345(1.89)  LDD0640  [2]
 LDCM0328  AC64 HEK-293T C293(0.91)  LDD1567  [4]
 LDCM0334  AC7 HCT 116 C345(1.82)  LDD0651  [2]
 LDCM0345  AC8 HCT 116 C345(2.65)  LDD0662  [2]
 LDCM0349  AC83 HCT 116 C345(0.67)  LDD0666  [2]
 LDCM0350  AC84 HCT 116 C345(0.71)  LDD0667  [2]
 LDCM0351  AC85 HCT 116 C345(0.87)  LDD0668  [2]
 LDCM0352  AC86 HCT 116 C345(0.85)  LDD0669  [2]
 LDCM0353  AC87 HCT 116 C345(0.66)  LDD0670  [2]
 LDCM0354  AC88 HCT 116 C345(0.54)  LDD0671  [2]
 LDCM0355  AC89 HCT 116 C345(1.06)  LDD0672  [2]
 LDCM0357  AC90 HCT 116 C345(0.67)  LDD0674  [2]
 LDCM0358  AC91 HCT 116 C345(0.78)  LDD0675  [2]
 LDCM0359  AC92 HCT 116 C345(0.71)  LDD0676  [2]
 LDCM0360  AC93 HCT 116 C345(0.83)  LDD0677  [2]
 LDCM0361  AC94 HCT 116 C345(1.23)  LDD0678  [2]
 LDCM0362  AC95 HCT 116 C345(0.90)  LDD0679  [2]
 LDCM0363  AC96 HCT 116 C345(0.79)  LDD0680  [2]
 LDCM0364  AC97 HCT 116 C345(1.17)  LDD0681  [2]
 LDCM0365  AC98 HCT 116 C345(1.25)  LDD0682  [2]
 LDCM0366  AC99 HCT 116 C345(0.88)  LDD0683  [2]
 LDCM0248  AKOS034007472 HCT 116 C345(1.65)  LDD0565  [2]
 LDCM0356  AKOS034007680 HCT 116 C345(1.93)  LDD0673  [2]
 LDCM0275  AKOS034007705 HCT 116 C345(2.94)  LDD0592  [2]
 LDCM0369  CL100 HCT 116 C345(1.26)  LDD0686  [2]
 LDCM0370  CL101 HCT 116 C345(2.42)  LDD0687  [2]
 LDCM0371  CL102 HCT 116 C345(2.38)  LDD0688  [2]
 LDCM0372  CL103 HCT 116 C345(1.25)  LDD0689  [2]
 LDCM0373  CL104 HCT 116 C345(1.64)  LDD0690  [2]
 LDCM0390  CL12 HEK-293T C293(1.13)  LDD1594  [4]
 LDCM0405  CL18 HEK-293T C293(0.98)  LDD1609  [4]
 LDCM0412  CL24 HEK-293T C293(1.22)  LDD1616  [4]
 LDCM0419  CL30 HEK-293T C293(1.06)  LDD1623  [4]
 LDCM0420  CL31 HCT 116 C345(0.92)  LDD0737  [2]
 LDCM0421  CL32 HCT 116 C345(0.90)  LDD0738  [2]
 LDCM0422  CL33 HCT 116 C345(0.93)  LDD0739  [2]
 LDCM0423  CL34 HCT 116 C345(1.21)  LDD0740  [2]
 LDCM0424  CL35 HCT 116 C345(1.21)  LDD0741  [2]
 LDCM0425  CL36 HCT 116 C345(1.09)  LDD0742  [2]
 LDCM0426  CL37 HCT 116 C345(1.46)  LDD0743  [2]
 LDCM0428  CL39 HCT 116 C345(1.26)  LDD0745  [2]
 LDCM0430  CL40 HCT 116 C345(1.07)  LDD0747  [2]
 LDCM0431  CL41 HCT 116 C345(0.93)  LDD0748  [2]
 LDCM0432  CL42 HCT 116 C345(0.83)  LDD0749  [2]
 LDCM0433  CL43 HCT 116 C345(1.23)  LDD0750  [2]
 LDCM0434  CL44 HCT 116 C345(1.19)  LDD0751  [2]
 LDCM0435  CL45 HCT 116 C345(1.32)  LDD0752  [2]
 LDCM0438  CL48 HEK-293T C293(1.11)  LDD1642  [4]
 LDCM0445  CL54 HEK-293T C293(1.00)  LDD1648  [4]
 LDCM0451  CL6 HEK-293T C293(1.10)  LDD1654  [4]
 LDCM0452  CL60 HEK-293T C293(1.00)  LDD1655  [4]
 LDCM0458  CL66 HEK-293T C293(1.03)  LDD1661  [4]
 LDCM0465  CL72 HEK-293T C293(1.07)  LDD1668  [4]
 LDCM0471  CL78 HEK-293T C293(1.02)  LDD1674  [4]
 LDCM0478  CL84 HEK-293T C293(0.87)  LDD1681  [4]
 LDCM0485  CL90 HEK-293T C293(0.86)  LDD1688  [4]
 LDCM0486  CL91 HCT 116 C345(1.03)  LDD0803  [2]
 LDCM0487  CL92 HCT 116 C345(1.10)  LDD0804  [2]
 LDCM0488  CL93 HCT 116 C345(0.92)  LDD0805  [2]
 LDCM0489  CL94 HCT 116 C345(1.18)  LDD0806  [2]
 LDCM0490  CL95 HCT 116 C345(1.38)  LDD0807  [2]
 LDCM0491  CL96 HCT 116 C345(1.18)  LDD0808  [2]
 LDCM0492  CL97 HCT 116 C345(0.88)  LDD0809  [2]
 LDCM0493  CL98 HCT 116 C345(1.08)  LDD0810  [2]
 LDCM0494  CL99 HCT 116 C345(1.14)  LDD0811  [2]
 LDCM0427  Fragment51 HCT 116 C345(0.87)  LDD0744  [2]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Transporter and channel
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
MyoD family inhibitor (MDFI) MDFI family Q99750
Other
Click To Hide/Show 14 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Cerebellar degeneration-related protein 2-like (CDR2L) CDR2 family Q86X02
Cysteine-rich tail protein 1 (CYSRT1) CYSRT1 family A8MQ03
Golgin subfamily A member 6-like protein 9 (GOLGA6L9) GOLGA6 family A6NEM1
Keratin, type I cytoskeletal 27 (KRT27) Intermediate filament family Q7Z3Y8
Keratin-associated protein 1-1 (KRTAP1-1) KRTAP type 1 family Q07627
Keratin-associated protein 10-6 (KRTAP10-6) KRTAP type 10 family P60371
Keratin-associated protein 10-8 (KRTAP10-8) KRTAP type 10 family P60410
Zinc finger protein 330 (ZNF330) NOA36 family Q9Y3S2
Paraneoplastic antigen Ma2 (PNMA2) PNMA family Q9UL42
Armadillo repeat-containing protein 7 (ARMC7) . Q9H6L4
Calcium-binding protein 5 (CABP5) . Q9NP86
Centrosomal protein of 70 kDa (CEP70) . Q8NHQ1
TNF receptor-associated factor 1 (TRAF1) . Q13077
Zinc finger C4H2 domain-containing protein (ZC4H2) . Q9NQZ6

References

1 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
2 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
3 Global profiling identifies a stress-responsive tyrosine site on EDC3 regulating biomolecular condensate formation. Cell Chem Biol. 2022 Dec 15;29(12):1709-1720.e7. doi: 10.1016/j.chembiol.2022.11.008. Epub 2022 Dec 6.
Mass spectrometry data entry: PXD038010
4 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402