Details of the Target

General Information of Target

Target ID LDTP09919
Target Name Ubiquitin recognition factor in ER-associated degradation protein 1 (UFD1)
Gene Name UFD1
Gene ID 7353
Synonyms
UFD1L; Ubiquitin recognition factor in ER-associated degradation protein 1; Ubiquitin fusion degradation protein 1; UB fusion protein 1
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MESGQPARRIAMAPLLEYERQLVLELLDTDGLVVCARGLGADRLLYHFLQLHCHPACLVL
VLNTQPAEEEYFINQLKIEGVEHLPRRVTNEITSNSRYEVYTQGGVIFATSRILVVDFLT
DRIPSDLITGILVYRAHRIIESCQEAFILRLFRQKNKRGFIKAFTDNAVAFDTGFCHVER
VMRNLFVRKLYLWPRFHVAVNSFLEQHKPEVVEIHVSMTPTMLAIQTAILDILNACLKEL
KCHNPSLEVEDLSLENAIGKPFDKTIRHYLDPLWHQLGAKTKSLVQDLKILRTLLQYLSQ
YDCVTFLNLLESLRATEKAFGQNSGWLFLDSSTSMFINARARVYHLPDAKMSKKEKISEK
MEIKEGEETKKELVLESNPKWEALTEVLKEIEAENKESEALGGPGQVLICASDDRTCSQL
RDYITLGAEAFLLRLYRKTFEKDSKAEEVWMKFRKEDSSKRIRKSHKRPKDPQNKERAST
KERTLKKKKRKLTLTQMVGKPEELEEEGDVEEGYRREISSSPESCPEEIKHEEFDVNLSS
DAAFGILKEPLTIIHPLLGCSDPYALTRVLHEVEPRYVVLYDAELTFVRQLEIYRASRPG
KPLRVYFLIYGGSTEEQRYLTALRKEKEAFEKLIREKASMVVPEEREGRDETNLDLVRGT
ASADVSTDTRKAGGQEQNGTQQSIVVDMREFRSELPSLIHRRGIDIEPVTLEVGDYILTP
EMCVERKSISDLIGSLNNGRLYSQCISMSRYYKRPVLLIEFDPSKPFSLTSRGALFQEIS
SNDISSKLTLLTLHFPRLRILWCPSPHATAELFEELKQSKPQPDAATALAITADSETLPE
SEKYNPGPQDFLLKMPGVNAKNCRSLMHHVKNIAELAALSQDELTSILGNAANAKQLYDF
IHTSFAEVVSKGKGKK
Target Bioclass
Other
Family
UFD1 family
Subcellular location
Nucleus
Function
Essential component of the ubiquitin-dependent proteolytic pathway which degrades ubiquitin fusion proteins. The ternary complex containing UFD1, VCP and NPLOC4 binds ubiquitinated proteins and is necessary for the export of misfolded proteins from the ER to the cytoplasm, where they are degraded by the proteasome. The NPLOC4-UFD1-VCP complex regulates spindle disassembly at the end of mitosis and is necessary for the formation of a closed nuclear envelope. It may be involved in the development of some ectoderm-derived structures. Acts as a negative regulator of type I interferon production via the complex formed with VCP and NPLOC4, which binds to RIGI and recruits RNF125 to promote ubiquitination and degradation of RIGI.
Uniprot ID
Q92890
Ensemble ID
ENST00000263202.15
HGNC ID
HGNC:12520

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 13 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		12.01  LDD0402  [1]
C-Sul
 Probe Info  		2.35  LDD0066  [2]
STPyne
 Probe Info  		K255(10.00)  LDD0277  [3]
Probe 1
 Probe Info  		Y219(13.57); Y261(33.22)  LDD3495  [4]
DBIA
 Probe Info  		C25(1.88)  LDD3311  [5]
HHS-465
 Probe Info  		Y63(4.21)  LDD2237  [6]
ATP probe
 Probe Info  		N.A.  LDD0199  [7]
4-Iodoacetamidophenylacetylene
 Probe Info  		C185(0.00); C25(0.00); C151(0.00)  LDD0038  [8]
IA-alkyne
 Probe Info  		C185(0.00); C25(0.00)  LDD0036  [8]
IPIAA_L
 Probe Info  		N.A.  LDD0031  [9]
Lodoacetamide azide
 Probe Info  		C185(0.00); C25(0.00); C151(0.00)  LDD0037  [8]
AOyne
 Probe Info  		11.50  LDD0443  [10]
NAIA_5
 Probe Info  		C25(0.00); C151(0.00)  LDD2223  [11]
PAL-AfBPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
VE-P
 Probe Info  		N.A.  LDD0396  [12]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HEK-293T C185(0.98)  LDD1507  [13]
 LDCM0215  AC10 HEK-293T C185(0.93)  LDD1508  [13]
 LDCM0226  AC11 HEK-293T C185(0.96)  LDD1509  [13]
 LDCM0237  AC12 HEK-293T C185(0.98)  LDD1510  [13]
 LDCM0259  AC14 HEK-293T C185(0.89)  LDD1512  [13]
 LDCM0270  AC15 HEK-293T C185(0.92)  LDD1513  [13]
 LDCM0276  AC17 HEK-293T C185(1.13)  LDD1515  [13]
 LDCM0277  AC18 HEK-293T C185(1.01)  LDD1516  [13]
 LDCM0278  AC19 HEK-293T C185(0.74)  LDD1517  [13]
 LDCM0279  AC2 HEK-293T C185(0.90)  LDD1518  [13]
 LDCM0280  AC20 HEK-293T C185(0.88)  LDD1519  [13]
 LDCM0282  AC22 HEK-293T C185(0.79)  LDD1521  [13]
 LDCM0283  AC23 HEK-293T C185(0.99)  LDD1522  [13]
 LDCM0284  AC24 HEK-293T C185(0.94)  LDD1523  [13]
 LDCM0285  AC25 HEK-293T C185(0.95)  LDD1524  [13]
 LDCM0286  AC26 HEK-293T C185(0.89)  LDD1525  [13]
 LDCM0287  AC27 HEK-293T C185(0.90)  LDD1526  [13]
 LDCM0288  AC28 HEK-293T C185(0.89)  LDD1527  [13]
 LDCM0290  AC3 HEK-293T C185(0.92)  LDD1529  [13]
 LDCM0291  AC30 HEK-293T C185(0.81)  LDD1530  [13]
 LDCM0292  AC31 HEK-293T C185(0.78)  LDD1531  [13]
 LDCM0293  AC32 HEK-293T C185(0.93)  LDD1532  [13]
 LDCM0294  AC33 HEK-293T C185(0.79)  LDD1533  [13]
 LDCM0295  AC34 HEK-293T C185(0.96)  LDD1534  [13]
 LDCM0296  AC35 HEK-293T C185(0.94)  LDD1535  [13]
 LDCM0297  AC36 HEK-293T C185(0.93)  LDD1536  [13]
 LDCM0299  AC38 HEK-293T C185(1.05)  LDD1538  [13]
 LDCM0300  AC39 HEK-293T C185(0.86)  LDD1539  [13]
 LDCM0301  AC4 HEK-293T C185(1.03)  LDD1540  [13]
 LDCM0302  AC40 HEK-293T C185(0.94)  LDD1541  [13]
 LDCM0303  AC41 HEK-293T C185(1.17)  LDD1542  [13]
 LDCM0304  AC42 HEK-293T C185(0.87)  LDD1543  [13]
 LDCM0305  AC43 HEK-293T C185(0.93)  LDD1544  [13]
 LDCM0306  AC44 HEK-293T C185(1.05)  LDD1545  [13]
 LDCM0308  AC46 HEK-293T C185(0.68)  LDD1547  [13]
 LDCM0309  AC47 HEK-293T C185(1.04)  LDD1548  [13]
 LDCM0310  AC48 HEK-293T C185(0.93)  LDD1549  [13]
 LDCM0311  AC49 HEK-293T C185(0.90)  LDD1550  [13]
 LDCM0313  AC50 HEK-293T C185(0.88)  LDD1552  [13]
 LDCM0314  AC51 HEK-293T C185(0.89)  LDD1553  [13]
 LDCM0315  AC52 HEK-293T C185(1.03)  LDD1554  [13]
 LDCM0317  AC54 HEK-293T C185(0.82)  LDD1556  [13]
 LDCM0318  AC55 HEK-293T C185(0.86)  LDD1557  [13]
 LDCM0319  AC56 HEK-293T C185(0.93)  LDD1558  [13]
 LDCM0320  AC57 HEK-293T C185(0.85)  LDD1559  [13]
 LDCM0321  AC58 HEK-293T C185(1.04)  LDD1560  [13]
 LDCM0322  AC59 HEK-293T C185(0.96)  LDD1561  [13]
 LDCM0323  AC6 HEK-293T C185(0.82)  LDD1562  [13]
 LDCM0324  AC60 HEK-293T C185(0.88)  LDD1563  [13]
 LDCM0326  AC62 HEK-293T C185(0.75)  LDD1565  [13]
 LDCM0327  AC63 HEK-293T C185(0.89)  LDD1566  [13]
 LDCM0328  AC64 HEK-293T C185(0.93)  LDD1567  [13]
 LDCM0334  AC7 HEK-293T C185(0.86)  LDD1568  [13]
 LDCM0345  AC8 HEK-293T C185(1.05)  LDD1569  [13]
 LDCM0356  AKOS034007680 HEK-293T C185(1.16)  LDD1570  [13]
 LDCM0275  AKOS034007705 HEK-293T C185(0.96)  LDD1514  [13]
 LDCM0156  Aniline NCI-H1299 10.88  LDD0403  [1]
 LDCM0367  CL1 HEK-293T C151(0.90); C185(1.06)  LDD1571  [13]
 LDCM0368  CL10 HEK-293T C185(1.16)  LDD1572  [13]
 LDCM0369  CL100 HEK-293T C185(0.81)  LDD1573  [13]
 LDCM0370  CL101 HEK-293T C151(0.93); C185(0.96)  LDD1574  [13]
 LDCM0371  CL102 HEK-293T C185(0.72)  LDD1575  [13]
 LDCM0372  CL103 HEK-293T C185(0.92)  LDD1576  [13]
 LDCM0373  CL104 HEK-293T C185(0.88)  LDD1577  [13]
 LDCM0374  CL105 HEK-293T C151(0.91); C185(0.92)  LDD1578  [13]
 LDCM0375  CL106 HEK-293T C185(0.91)  LDD1579  [13]
 LDCM0376  CL107 HEK-293T C185(0.98)  LDD1580  [13]
 LDCM0377  CL108 HEK-293T C185(0.87)  LDD1581  [13]
 LDCM0378  CL109 HEK-293T C151(0.88); C185(0.95)  LDD1582  [13]
 LDCM0379  CL11 HEK-293T C185(0.80)  LDD1583  [13]
 LDCM0380  CL110 HEK-293T C185(0.83)  LDD1584  [13]
 LDCM0381  CL111 HEK-293T C185(0.98)  LDD1585  [13]
 LDCM0382  CL112 HEK-293T C185(0.93)  LDD1586  [13]
 LDCM0383  CL113 HEK-293T C151(0.93); C185(1.14)  LDD1587  [13]
 LDCM0384  CL114 HEK-293T C185(0.80)  LDD1588  [13]
 LDCM0385  CL115 HEK-293T C185(0.98)  LDD1589  [13]
 LDCM0386  CL116 HEK-293T C185(0.96)  LDD1590  [13]
 LDCM0387  CL117 HEK-293T C151(0.98); C185(1.02)  LDD1591  [13]
 LDCM0388  CL118 HEK-293T C185(0.94)  LDD1592  [13]
 LDCM0389  CL119 HEK-293T C185(1.03)  LDD1593  [13]
 LDCM0390  CL12 HEK-293T C185(1.17)  LDD1594  [13]
 LDCM0391  CL120 HEK-293T C185(0.93)  LDD1595  [13]
 LDCM0392  CL121 HEK-293T C151(1.08); C185(1.03)  LDD1596  [13]
 LDCM0393  CL122 HEK-293T C185(0.91)  LDD1597  [13]
 LDCM0394  CL123 HEK-293T C185(0.94)  LDD1598  [13]
 LDCM0395  CL124 HEK-293T C185(0.88)  LDD1599  [13]
 LDCM0396  CL125 HEK-293T C151(0.99); C185(0.96)  LDD1600  [13]
 LDCM0397  CL126 HEK-293T C185(0.82)  LDD1601  [13]
 LDCM0398  CL127 HEK-293T C185(0.89)  LDD1602  [13]
 LDCM0399  CL128 HEK-293T C185(0.81)  LDD1603  [13]
 LDCM0400  CL13 HEK-293T C151(0.93); C185(0.98)  LDD1604  [13]
 LDCM0401  CL14 HEK-293T C185(0.98)  LDD1605  [13]
 LDCM0402  CL15 HEK-293T C185(1.11)  LDD1606  [13]
 LDCM0403  CL16 HEK-293T C185(0.95)  LDD1607  [13]
 LDCM0404  CL17 HEK-293T C185(0.92)  LDD1608  [13]
 LDCM0405  CL18 HEK-293T C185(1.19)  LDD1609  [13]
 LDCM0406  CL19 HEK-293T C185(1.25)  LDD1610  [13]
 LDCM0407  CL2 HEK-293T C185(0.99)  LDD1611  [13]
 LDCM0408  CL20 HEK-293T C185(1.28)  LDD1612  [13]
 LDCM0410  CL22 HEK-293T C185(1.49)  LDD1614  [13]
 LDCM0411  CL23 HEK-293T C185(1.00)  LDD1615  [13]
 LDCM0412  CL24 HEK-293T C185(1.14)  LDD1616  [13]
 LDCM0413  CL25 HEK-293T C151(1.23); C185(1.00)  LDD1617  [13]
 LDCM0414  CL26 HEK-293T C185(0.79)  LDD1618  [13]
 LDCM0415  CL27 HEK-293T C185(1.08)  LDD1619  [13]
 LDCM0416  CL28 HEK-293T C185(1.03)  LDD1620  [13]
 LDCM0417  CL29 HEK-293T C185(1.26)  LDD1621  [13]
 LDCM0418  CL3 HEK-293T C185(1.08)  LDD1622  [13]
 LDCM0419  CL30 HEK-293T C185(1.11)  LDD1623  [13]
 LDCM0420  CL31 HEK-293T C185(1.09)  LDD1624  [13]
 LDCM0421  CL32 HEK-293T C185(1.21)  LDD1625  [13]
 LDCM0423  CL34 HEK-293T C185(1.13)  LDD1627  [13]
 LDCM0424  CL35 HEK-293T C185(0.98)  LDD1628  [13]
 LDCM0425  CL36 HEK-293T C185(1.15)  LDD1629  [13]
 LDCM0426  CL37 HEK-293T C151(1.08); C185(0.93)  LDD1630  [13]
 LDCM0428  CL39 HEK-293T C185(1.04)  LDD1632  [13]
 LDCM0429  CL4 HEK-293T C185(0.92)  LDD1633  [13]
 LDCM0430  CL40 HEK-293T C185(1.14)  LDD1634  [13]
 LDCM0431  CL41 HEK-293T C185(0.98)  LDD1635  [13]
 LDCM0432  CL42 HEK-293T C185(1.41)  LDD1636  [13]
 LDCM0433  CL43 HEK-293T C185(1.18)  LDD1637  [13]
 LDCM0434  CL44 HEK-293T C185(1.18)  LDD1638  [13]
 LDCM0436  CL46 HEK-293T C185(1.14)  LDD1640  [13]
 LDCM0437  CL47 HEK-293T C185(1.28)  LDD1641  [13]
 LDCM0438  CL48 HEK-293T C185(1.15)  LDD1642  [13]
 LDCM0439  CL49 HEK-293T C151(0.96); C185(1.05)  LDD1643  [13]
 LDCM0440  CL5 HEK-293T C185(1.24)  LDD1644  [13]
 LDCM0441  CL50 HEK-293T C185(1.03)  LDD1645  [13]
 LDCM0443  CL52 HEK-293T C185(0.89)  LDD1646  [13]
 LDCM0444  CL53 HEK-293T C185(0.94)  LDD1647  [13]
 LDCM0445  CL54 HEK-293T C185(1.06)  LDD1648  [13]
 LDCM0446  CL55 HEK-293T C185(1.22)  LDD1649  [13]
 LDCM0447  CL56 HEK-293T C185(1.32)  LDD1650  [13]
 LDCM0449  CL58 HEK-293T C185(1.55)  LDD1652  [13]
 LDCM0450  CL59 HEK-293T C185(0.96)  LDD1653  [13]
 LDCM0451  CL6 HEK-293T C185(1.07)  LDD1654  [13]
 LDCM0452  CL60 HEK-293T C185(1.11)  LDD1655  [13]
 LDCM0453  CL61 HEK-293T C151(0.96); C185(0.94)  LDD1656  [13]
 LDCM0454  CL62 HEK-293T C185(0.92)  LDD1657  [13]
 LDCM0455  CL63 HEK-293T C185(0.89)  LDD1658  [13]
 LDCM0456  CL64 HEK-293T C185(0.88)  LDD1659  [13]
 LDCM0457  CL65 HEK-293T C185(1.08)  LDD1660  [13]
 LDCM0458  CL66 HEK-293T C185(1.07)  LDD1661  [13]
 LDCM0459  CL67 HEK-293T C185(1.15)  LDD1662  [13]
 LDCM0460  CL68 HEK-293T C185(1.20)  LDD1663  [13]
 LDCM0462  CL7 HEK-293T C185(1.15)  LDD1665  [13]
 LDCM0463  CL70 HEK-293T C185(1.29)  LDD1666  [13]
 LDCM0464  CL71 HEK-293T C185(1.19)  LDD1667  [13]
 LDCM0465  CL72 HEK-293T C185(1.17)  LDD1668  [13]
 LDCM0466  CL73 HEK-293T C151(1.21); C185(0.96)  LDD1669  [13]
 LDCM0467  CL74 HEK-293T C185(0.93)  LDD1670  [13]
 LDCM0469  CL76 HEK-293T C185(0.94)  LDD1672  [13]
 LDCM0470  CL77 HEK-293T C185(0.99)  LDD1673  [13]
 LDCM0471  CL78 HEK-293T C185(1.08)  LDD1674  [13]
 LDCM0472  CL79 HEK-293T C185(1.14)  LDD1675  [13]
 LDCM0473  CL8 HEK-293T C185(1.07)  LDD1676  [13]
 LDCM0474  CL80 HEK-293T C185(1.25)  LDD1677  [13]
 LDCM0476  CL82 HEK-293T C185(1.11)  LDD1679  [13]
 LDCM0477  CL83 HEK-293T C185(1.08)  LDD1680  [13]
 LDCM0478  CL84 HEK-293T C185(0.98)  LDD1681  [13]
 LDCM0479  CL85 HEK-293T C151(1.00); C185(0.91)  LDD1682  [13]
 LDCM0480  CL86 HEK-293T C185(0.84)  LDD1683  [13]
 LDCM0481  CL87 HEK-293T C185(0.92)  LDD1684  [13]
 LDCM0482  CL88 HEK-293T C185(0.84)  LDD1685  [13]
 LDCM0483  CL89 HEK-293T C185(0.89)  LDD1686  [13]
 LDCM0485  CL90 HEK-293T C185(0.82)  LDD1688  [13]
 LDCM0486  CL91 HEK-293T C185(1.05)  LDD1689  [13]
 LDCM0487  CL92 HEK-293T C185(1.04)  LDD1690  [13]
 LDCM0489  CL94 HEK-293T C185(1.12)  LDD1692  [13]
 LDCM0490  CL95 HEK-293T C185(0.94)  LDD1693  [13]
 LDCM0491  CL96 HEK-293T C185(1.07)  LDD1694  [13]
 LDCM0492  CL97 HEK-293T C151(1.29); C185(0.99)  LDD1695  [13]
 LDCM0493  CL98 HEK-293T C185(0.95)  LDD1696  [13]
 LDCM0494  CL99 HEK-293T C185(0.99)  LDD1697  [13]
 LDCM0495  E2913 HEK-293T C185(1.04)  LDD1698  [13]
 LDCM0625  F8 Ramos C25(0.92)  LDD2187  [14]
 LDCM0572  Fragment10 Ramos C25(0.70)  LDD2189  [14]
 LDCM0573  Fragment11 Ramos C25(3.21)  LDD2190  [14]
 LDCM0574  Fragment12 Ramos C25(0.96)  LDD2191  [14]
 LDCM0575  Fragment13 Ramos C25(1.37)  LDD2192  [14]
 LDCM0576  Fragment14 Ramos C25(1.25)  LDD2193  [14]
 LDCM0579  Fragment20 Ramos C25(0.93)  LDD2194  [14]
 LDCM0580  Fragment21 Ramos C25(1.12)  LDD2195  [14]
 LDCM0582  Fragment23 Ramos C25(1.47)  LDD2196  [14]
 LDCM0578  Fragment27 Ramos C25(1.24)  LDD2197  [14]
 LDCM0586  Fragment28 Ramos C25(1.02)  LDD2198  [14]
 LDCM0588  Fragment30 Ramos C25(1.12)  LDD2199  [14]
 LDCM0589  Fragment31 Ramos C25(1.42)  LDD2200  [14]
 LDCM0590  Fragment32 Ramos C25(0.68)  LDD2201  [14]
 LDCM0468  Fragment33 HEK-293T C185(1.05)  LDD1671  [13]
 LDCM0596  Fragment38 Ramos C25(1.24)  LDD2203  [14]
 LDCM0566  Fragment4 Ramos C25(0.86)  LDD2184  [14]
 LDCM0427  Fragment51 HEK-293T C185(0.88)  LDD1631  [13]
 LDCM0610  Fragment52 Ramos C25(1.26)  LDD2204  [14]
 LDCM0614  Fragment56 Ramos C25(0.95)  LDD2205  [14]
 LDCM0569  Fragment7 Ramos C25(0.59)  LDD2186  [14]
 LDCM0571  Fragment9 Ramos C25(0.67)  LDD2188  [14]
 LDCM0022  KB02 Ramos C25(0.52)  LDD2182  [14]
 LDCM0023  KB03 Ramos C25(0.70)  LDD2183  [14]
 LDCM0024  KB05 G361 C25(1.88)  LDD3311  [5]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Transitional endoplasmic reticulum ATPase (VCP) AAA ATPase family P55072
Transporter and channel
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Huntingtin (HTT) Huntingtin family P42858
Nuclear protein localization protein 4 homolog (NPLOC4) NPL4 family Q8TAT6

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 Low-Toxicity Sulfonium-Based Probes for Cysteine-Specific Profiling in Live Cells. Anal Chem. 2022 Mar 15;94(10):4366-4372. doi: 10.1021/acs.analchem.1c05129. Epub 2022 Mar 4.
3 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
4 An Azo Coupling-Based Chemoproteomic Approach to Systematically Profile the Tyrosine Reactivity in the Human Proteome. Anal Chem. 2021 Jul 27;93(29):10334-10342. doi: 10.1021/acs.analchem.1c01935. Epub 2021 Jul 12.
5 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
6 Global targeting of functional tyrosines using sulfur-triazole exchange chemistry. Nat Chem Biol. 2020 Feb;16(2):150-159. doi: 10.1038/s41589-019-0404-5. Epub 2019 Nov 25.
7 Targeted Proteomic Approaches for Proteome-Wide Characterizations of the AMP-Binding Capacities of Kinases. J Proteome Res. 2022 Aug 5;21(8):2063-2070. doi: 10.1021/acs.jproteome.2c00225. Epub 2022 Jul 12.
8 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
9 SP3-Enabled Rapid and High Coverage Chemoproteomic Identification of Cell-State-Dependent Redox-Sensitive Cysteines. Mol Cell Proteomics. 2022 Apr;21(4):100218. doi: 10.1016/j.mcpro.2022.100218. Epub 2022 Feb 25.
Mass spectrometry data entry: PXD029500 , PXD031647
10 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
11 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
12 Pharmacological Targeting of Vacuolar H(+)-ATPase via Subunit V1G Combats Multidrug-Resistant Cancer. Cell Chem Biol. 2020 Nov 19;27(11):1359-1370.e8. doi: 10.1016/j.chembiol.2020.06.011. Epub 2020 Jul 9.
13 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
14 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578