Details of the Target

General Information of Target

Target ID LDTP09880
Target Name NEDD4-binding protein 2-like 2 (N4BP2L2)
Gene Name N4BP2L2
Gene ID 10443
Synonyms
CG005; PFAAP5; NEDD4-binding protein 2-like 2; Phosphonoformate immuno-associated protein 5
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MEIPNPPTSKCITYWKRKVKSEYMRLRQLKRLQANMGAKALYVANFAKVQEKTQILNEEW
KKLRVQPVQSMKPVSGHPFLKKCTIESIFPGFASQHMLMRSLNTVALVPIMYSWSPLQQN
FMVEDETVLCNIPYMGDEVKEEDETFIEELINNYDGKVHGEEEMIPGSVLISDAVFLELV
DALNQYSDEEEEGHNDTSDGKQDDSKEDLPVTRKRKRHAIEGNKKSSKKQFPNDMIFSAI
ASMFPENGVPDDMKERYRELTEMSDPNALPPQCTPNIDGPNAKSVQREQSLHSFHTLFCR
RCFKYDCFLHPFHATPNVYKRKNKEIKIEPEPCGTDCFLLLEGAKEYAMLHNPRSKCSGR
RRRRHHIVSASCSNASASAVAETKEGDSDRDTGNDWASSSSEANSRCQTPTKQKASPAPP
QLCVVEAPSEPVEWTGAEESLFRVFHGTYFNNFCSIARLLGTKTCKQVFQFAVKESLILK
LPTDELMNPSQKKKRKHRLWAAHCRKIQLKKDNSSTQVYNYQPCDHPDRPCDSTCPCIMT
QNFCEKFCQCNPDCQNRFPGCRCKTQCNTKQCPCYLAVRECDPDLCLTCGASEHWDCKVV
SCKNCSIQRGLKKHLLLAPSDVAGWGTFIKESVQKNEFISEYCGELISQDEADRRGKVYD
KYMSSFLFNLNNDFVVDATRKGNKIRFANHSVNPNCYAKVVMVNGDHRIGIFAKRAIQAG
EELFFDYRYSQADALKYVGIERETDVL
Target Bioclass
Other
Uniprot ID
Q92802
Ensemble ID
ENST00000267068.6
HGNC ID
HGNC:26916

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
42MGBA SNV: p.H38R .
CAL51 SNV: p.S118N DBIA    Probe Info 
DOTC24510 Deletion: p.H38PfsTer7 .
HCT15 SNV: p.W54C DBIA    Probe Info 
HT115 SNV: p.T75P DBIA    Probe Info 
JURKAT SNV: p.R106C .
MDAMB231 SNV: p.E142K .
OCILY3 SNV: p.W483G .
OVK18 Deletion: p.H36TfsTer22 .
REH SNV: p.S163F .
SW948 SNV: p.S413F DBIA    Probe Info 
T24 SNV: p.R371I .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 4 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C193(0.82)  LDD0533  [1]
NAIA_5
 Probe Info  		N.A.  LDD2225  [2]
Compound 11
 Probe Info  		N.A.  LDD2213  [3]
AOyne
 Probe Info  		12.00  LDD0443  [4]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 PaTu 8988t C193(1.71)  LDD1093  [1]
 LDCM0215  AC10 HEK-293T C193(0.93)  LDD0813  [1]
 LDCM0216  AC100 HCT 116 C193(0.82)  LDD0533  [1]
 LDCM0217  AC101 HCT 116 C193(0.93)  LDD0534  [1]
 LDCM0218  AC102 HCT 116 C193(0.95)  LDD0535  [1]
 LDCM0219  AC103 HCT 116 C193(0.90)  LDD0536  [1]
 LDCM0220  AC104 HCT 116 C193(1.08)  LDD0537  [1]
 LDCM0221  AC105 HCT 116 C193(1.20)  LDD0538  [1]
 LDCM0222  AC106 HCT 116 C193(1.09)  LDD0539  [1]
 LDCM0223  AC107 HCT 116 C193(0.81)  LDD0540  [1]
 LDCM0224  AC108 HCT 116 C193(0.78)  LDD0541  [1]
 LDCM0225  AC109 HCT 116 C193(0.76)  LDD0542  [1]
 LDCM0226  AC11 HEK-293T C193(0.91)  LDD0824  [1]
 LDCM0227  AC110 HCT 116 C193(0.96)  LDD0544  [1]
 LDCM0228  AC111 HCT 116 C193(1.12)  LDD0545  [1]
 LDCM0229  AC112 HCT 116 C193(0.70)  LDD0546  [1]
 LDCM0230  AC113 HEK-293T C193(1.08)  LDD0828  [1]
 LDCM0231  AC114 HEK-293T C193(0.81)  LDD0829  [1]
 LDCM0232  AC115 HEK-293T C193(0.96)  LDD0830  [1]
 LDCM0233  AC116 HEK-293T C193(1.05)  LDD0831  [1]
 LDCM0234  AC117 HEK-293T C193(1.08)  LDD0832  [1]
 LDCM0235  AC118 HEK-293T C193(0.89)  LDD0833  [1]
 LDCM0236  AC119 HEK-293T C193(1.04)  LDD0834  [1]
 LDCM0237  AC12 HEK-293T C193(0.90)  LDD0835  [1]
 LDCM0238  AC120 HEK-293T C193(0.91)  LDD0836  [1]
 LDCM0239  AC121 HEK-293T C193(1.27)  LDD0837  [1]
 LDCM0240  AC122 HEK-293T C193(1.08)  LDD0838  [1]
 LDCM0241  AC123 HEK-293T C193(0.97)  LDD0839  [1]
 LDCM0242  AC124 HEK-293T C193(1.10)  LDD0840  [1]
 LDCM0243  AC125 HEK-293T C193(1.16)  LDD0841  [1]
 LDCM0244  AC126 HEK-293T C193(1.19)  LDD0842  [1]
 LDCM0245  AC127 HEK-293T C193(0.89)  LDD0843  [1]
 LDCM0259  AC14 HEK-293T C193(0.87)  LDD0857  [1]
 LDCM0263  AC143 HCT 116 C193(1.14)  LDD0580  [1]
 LDCM0264  AC144 HCT 116 C193(1.55)  LDD0581  [1]
 LDCM0265  AC145 HCT 116 C193(1.04)  LDD0582  [1]
 LDCM0266  AC146 HCT 116 C193(1.24)  LDD0583  [1]
 LDCM0267  AC147 HCT 116 C193(2.99)  LDD0584  [1]
 LDCM0268  AC148 HCT 116 C193(3.13)  LDD0585  [1]
 LDCM0269  AC149 HCT 116 C193(2.48)  LDD0586  [1]
 LDCM0270  AC15 HEK-293T C193(1.02)  LDD0868  [1]
 LDCM0271  AC150 HCT 116 C193(0.99)  LDD0588  [1]
 LDCM0272  AC151 HCT 116 C193(1.02)  LDD0589  [1]
 LDCM0273  AC152 HCT 116 C193(1.24)  LDD0590  [1]
 LDCM0274  AC153 HCT 116 C193(2.17)  LDD0591  [1]
 LDCM0621  AC154 HCT 116 C193(1.47)  LDD2158  [1]
 LDCM0622  AC155 HCT 116 C193(1.58)  LDD2159  [1]
 LDCM0623  AC156 HCT 116 C193(1.24)  LDD2160  [1]
 LDCM0624  AC157 HCT 116 C193(1.02)  LDD2161  [1]
 LDCM0276  AC17 HCT 116 C193(1.56)  LDD0593  [1]
 LDCM0277  AC18 HCT 116 C193(2.36)  LDD0594  [1]
 LDCM0278  AC19 HCT 116 C193(1.11)  LDD0595  [1]
 LDCM0279  AC2 PaTu 8988t C193(1.58)  LDD1158  [1]
 LDCM0280  AC20 HCT 116 C193(1.16)  LDD0597  [1]
 LDCM0281  AC21 HCT 116 C193(1.24)  LDD0598  [1]
 LDCM0282  AC22 HCT 116 C193(1.00)  LDD0599  [1]
 LDCM0283  AC23 HCT 116 C193(1.62)  LDD0600  [1]
 LDCM0284  AC24 HCT 116 C193(0.95)  LDD0601  [1]
 LDCM0286  AC26 HEK-293T C578(1.02)  LDD1525  [5]
 LDCM0289  AC29 HEK-293T C578(1.32)  LDD1528  [5]
 LDCM0290  AC3 PaTu 8988t C193(1.68)  LDD1169  [1]
 LDCM0292  AC31 HEK-293T C578(1.04)  LDD1531  [5]
 LDCM0295  AC34 HEK-293T C578(1.11)  LDD1534  [5]
 LDCM0298  AC37 HEK-293T C578(0.94)  LDD1537  [5]
 LDCM0300  AC39 HEK-293T C578(0.95)  LDD1539  [5]
 LDCM0301  AC4 PaTu 8988t C193(1.27)  LDD1180  [1]
 LDCM0304  AC42 HEK-293T C578(1.04)  LDD1543  [5]
 LDCM0307  AC45 HEK-293T C578(1.06)  LDD1546  [5]
 LDCM0309  AC47 HEK-293T C578(1.32)  LDD1548  [5]
 LDCM0312  AC5 PaTu 8988t C193(1.66)  LDD1191  [1]
 LDCM0313  AC50 HEK-293T C578(1.08)  LDD1552  [5]
 LDCM0316  AC53 HEK-293T C578(0.91)  LDD1555  [5]
 LDCM0318  AC55 HEK-293T C578(1.12)  LDD1557  [5]
 LDCM0321  AC58 HEK-293T C578(1.21)  LDD1560  [5]
 LDCM0323  AC6 HEK-293T C193(0.87)  LDD0921  [1]
 LDCM0325  AC61 HEK-293T C578(0.92)  LDD1564  [5]
 LDCM0327  AC63 HEK-293T C578(1.00)  LDD1566  [5]
 LDCM0334  AC7 HEK-293T C193(1.28)  LDD0932  [1]
 LDCM0345  AC8 HEK-293T C193(0.92)  LDD0943  [1]
 LDCM0349  AC83 HCT 116 C193(2.64)  LDD0666  [1]
 LDCM0350  AC84 HCT 116 C193(2.11)  LDD0667  [1]
 LDCM0351  AC85 HCT 116 C193(1.54)  LDD0668  [1]
 LDCM0352  AC86 HCT 116 C193(1.61)  LDD0669  [1]
 LDCM0353  AC87 HCT 116 C193(1.20)  LDD0670  [1]
 LDCM0354  AC88 HCT 116 C193(1.50)  LDD0671  [1]
 LDCM0355  AC89 HCT 116 C193(1.69)  LDD0672  [1]
 LDCM0357  AC90 HCT 116 C193(0.89)  LDD0674  [1]
 LDCM0358  AC91 HCT 116 C193(2.19)  LDD0675  [1]
 LDCM0359  AC92 HCT 116 C193(1.98)  LDD0676  [1]
 LDCM0360  AC93 HCT 116 C193(1.43)  LDD0677  [1]
 LDCM0361  AC94 HCT 116 C193(1.40)  LDD0678  [1]
 LDCM0362  AC95 HCT 116 C193(1.67)  LDD0679  [1]
 LDCM0363  AC96 HCT 116 C193(1.86)  LDD0680  [1]
 LDCM0364  AC97 HCT 116 C193(1.64)  LDD0681  [1]
 LDCM0365  AC98 HCT 116 C193(1.00)  LDD0682  [1]
 LDCM0366  AC99 HCT 116 C193(0.75)  LDD0683  [1]
 LDCM0248  AKOS034007472 HEK-293T C193(1.01)  LDD0846  [1]
 LDCM0356  AKOS034007680 HEK-293T C193(1.25)  LDD0954  [1]
 LDCM0275  AKOS034007705 HEK-293T C193(0.84)  LDD0873  [1]
 LDCM0367  CL1 PaTu 8988t C193(0.88)  LDD1246  [1]
 LDCM0368  CL10 PaTu 8988t C193(1.27)  LDD1247  [1]
 LDCM0369  CL100 PaTu 8988t C193(1.33)  LDD1248  [1]
 LDCM0370  CL101 HEK-293T C193(0.83)  LDD0968  [1]
 LDCM0371  CL102 HEK-293T C193(1.07)  LDD0969  [1]
 LDCM0372  CL103 HEK-293T C193(1.08)  LDD0970  [1]
 LDCM0373  CL104 HEK-293T C193(0.81)  LDD0971  [1]
 LDCM0374  CL105 HCT 116 C193(1.46)  LDD0691  [1]
 LDCM0375  CL106 HCT 116 C193(1.87)  LDD0692  [1]
 LDCM0376  CL107 HCT 116 C193(1.83)  LDD0693  [1]
 LDCM0377  CL108 HCT 116 C193(1.69)  LDD0694  [1]
 LDCM0378  CL109 HCT 116 C193(1.23)  LDD0695  [1]
 LDCM0379  CL11 PaTu 8988t C193(0.81)  LDD1258  [1]
 LDCM0380  CL110 HCT 116 C193(1.54)  LDD0697  [1]
 LDCM0381  CL111 HCT 116 C193(1.02)  LDD0698  [1]
 LDCM0384  CL114 HEK-293T C578(1.13)  LDD1588  [5]
 LDCM0385  CL115 HEK-293T C578(1.41)  LDD1589  [5]
 LDCM0388  CL118 HEK-293T C578(0.98)  LDD1592  [5]
 LDCM0389  CL119 HEK-293T C578(0.87)  LDD1593  [5]
 LDCM0390  CL12 PaTu 8988t C193(0.88)  LDD1269  [1]
 LDCM0393  CL122 HEK-293T C578(0.96)  LDD1597  [5]
 LDCM0394  CL123 HEK-293T C578(1.06)  LDD1598  [5]
 LDCM0397  CL126 HEK-293T C578(0.98)  LDD1601  [5]
 LDCM0398  CL127 HEK-293T C578(0.91)  LDD1602  [5]
 LDCM0400  CL13 PaTu 8988t C193(1.16)  LDD1279  [1]
 LDCM0401  CL14 PaTu 8988t C193(1.13)  LDD1280  [1]
 LDCM0402  CL15 PaTu 8988t C193(1.04)  LDD1281  [1]
 LDCM0403  CL16 HEK-293T C193(0.91)  LDD1001  [1]
 LDCM0404  CL17 HEK-293T C193(1.08)  LDD1002  [1]
 LDCM0405  CL18 HEK-293T C193(0.96)  LDD1003  [1]
 LDCM0406  CL19 HEK-293T C193(0.88)  LDD1004  [1]
 LDCM0407  CL2 PaTu 8988t C193(0.90)  LDD1286  [1]
 LDCM0408  CL20 HEK-293T C193(1.02)  LDD1006  [1]
 LDCM0409  CL21 HEK-293T C193(1.57)  LDD1007  [1]
 LDCM0410  CL22 HEK-293T C193(0.99)  LDD1008  [1]
 LDCM0411  CL23 HEK-293T C193(0.73)  LDD1009  [1]
 LDCM0412  CL24 HEK-293T C193(0.90)  LDD1010  [1]
 LDCM0413  CL25 HEK-293T C193(1.46)  LDD1011  [1]
 LDCM0414  CL26 HEK-293T C193(0.88)  LDD1012  [1]
 LDCM0415  CL27 HEK-293T C193(0.97)  LDD1013  [1]
 LDCM0416  CL28 HEK-293T C193(0.93)  LDD1014  [1]
 LDCM0417  CL29 HEK-293T C193(0.93)  LDD1015  [1]
 LDCM0418  CL3 PaTu 8988t C193(1.25)  LDD1297  [1]
 LDCM0419  CL30 HEK-293T C193(1.10)  LDD1017  [1]
 LDCM0420  CL31 HCT 116 C193(1.07)  LDD0737  [1]
 LDCM0421  CL32 HCT 116 C193(1.09)  LDD0738  [1]
 LDCM0422  CL33 HCT 116 C193(2.05)  LDD0739  [1]
 LDCM0423  CL34 HCT 116 C193(1.50)  LDD0740  [1]
 LDCM0424  CL35 HCT 116 C193(1.25)  LDD0741  [1]
 LDCM0425  CL36 HCT 116 C193(1.19)  LDD0742  [1]
 LDCM0426  CL37 HCT 116 C193(1.77)  LDD0743  [1]
 LDCM0428  CL39 HCT 116 C193(1.35)  LDD0745  [1]
 LDCM0429  CL4 PaTu 8988t C193(0.92)  LDD1308  [1]
 LDCM0430  CL40 HCT 116 C193(1.30)  LDD0747  [1]
 LDCM0431  CL41 HCT 116 C193(1.32)  LDD0748  [1]
 LDCM0432  CL42 HCT 116 C193(1.85)  LDD0749  [1]
 LDCM0433  CL43 HCT 116 C193(2.24)  LDD0750  [1]
 LDCM0434  CL44 HCT 116 C193(1.73)  LDD0751  [1]
 LDCM0435  CL45 HCT 116 C193(1.70)  LDD0752  [1]
 LDCM0436  CL46 HEK-293T C193(1.15)  LDD1034  [1]
 LDCM0437  CL47 HEK-293T C193(0.95)  LDD1035  [1]
 LDCM0438  CL48 HEK-293T C193(1.04)  LDD1036  [1]
 LDCM0439  CL49 HEK-293T C193(1.12)  LDD1037  [1]
 LDCM0440  CL5 PaTu 8988t C193(0.96)  LDD1319  [1]
 LDCM0441  CL50 HEK-293T C193(1.28)  LDD1039  [1]
 LDCM0442  CL51 HEK-293T C193(1.34)  LDD1040  [1]
 LDCM0443  CL52 HEK-293T C193(0.93)  LDD1041  [1]
 LDCM0444  CL53 HEK-293T C193(1.79)  LDD1042  [1]
 LDCM0445  CL54 HEK-293T C193(1.72)  LDD1043  [1]
 LDCM0446  CL55 HEK-293T C193(1.28)  LDD1044  [1]
 LDCM0447  CL56 HEK-293T C193(1.14)  LDD1045  [1]
 LDCM0448  CL57 HEK-293T C193(1.16)  LDD1046  [1]
 LDCM0449  CL58 HEK-293T C193(0.79)  LDD1047  [1]
 LDCM0450  CL59 HEK-293T C193(1.08)  LDD1048  [1]
 LDCM0451  CL6 PaTu 8988t C193(1.40)  LDD1330  [1]
 LDCM0452  CL60 HEK-293T C193(1.36)  LDD1050  [1]
 LDCM0453  CL61 PaTu 8988t C193(0.91)  LDD1332  [1]
 LDCM0454  CL62 PaTu 8988t C193(0.50)  LDD1333  [1]
 LDCM0455  CL63 PaTu 8988t C193(0.82)  LDD1334  [1]
 LDCM0456  CL64 PaTu 8988t C193(0.66)  LDD1335  [1]
 LDCM0457  CL65 PaTu 8988t C193(0.69)  LDD1336  [1]
 LDCM0458  CL66 PaTu 8988t C193(0.60)  LDD1337  [1]
 LDCM0459  CL67 PaTu 8988t C193(1.38)  LDD1338  [1]
 LDCM0460  CL68 PaTu 8988t C193(1.67)  LDD1339  [1]
 LDCM0461  CL69 PaTu 8988t C193(1.02)  LDD1340  [1]
 LDCM0462  CL7 PaTu 8988t C193(1.50)  LDD1341  [1]
 LDCM0463  CL70 PaTu 8988t C193(1.12)  LDD1342  [1]
 LDCM0464  CL71 PaTu 8988t C193(1.05)  LDD1343  [1]
 LDCM0465  CL72 PaTu 8988t C193(0.40)  LDD1344  [1]
 LDCM0466  CL73 PaTu 8988t C193(1.31)  LDD1345  [1]
 LDCM0467  CL74 PaTu 8988t C193(1.04)  LDD1346  [1]
 LDCM0471  CL78 HEK-293T C578(1.05)  LDD1674  [5]
 LDCM0473  CL8 PaTu 8988t C193(1.02)  LDD1352  [1]
 LDCM0475  CL81 HEK-293T C578(0.91)  LDD1678  [5]
 LDCM0477  CL83 HEK-293T C578(1.09)  LDD1680  [5]
 LDCM0480  CL86 HEK-293T C578(0.87)  LDD1683  [5]
 LDCM0481  CL87 HEK-293T C578(1.10)  LDD1684  [5]
 LDCM0484  CL9 PaTu 8988t C193(1.11)  LDD1363  [1]
 LDCM0485  CL90 HEK-293T C578(1.03)  LDD1688  [5]
 LDCM0486  CL91 PaTu 8988t C193(1.06)  LDD1365  [1]
 LDCM0487  CL92 PaTu 8988t C193(1.52)  LDD1366  [1]
 LDCM0488  CL93 PaTu 8988t C193(1.28)  LDD1367  [1]
 LDCM0489  CL94 PaTu 8988t C193(1.90)  LDD1368  [1]
 LDCM0490  CL95 PaTu 8988t C193(1.84)  LDD1369  [1]
 LDCM0491  CL96 PaTu 8988t C193(1.12)  LDD1370  [1]
 LDCM0492  CL97 PaTu 8988t C193(1.18)  LDD1371  [1]
 LDCM0493  CL98 PaTu 8988t C193(2.20)  LDD1372  [1]
 LDCM0494  CL99 PaTu 8988t C193(1.65)  LDD1373  [1]
 LDCM0495  E2913 HEK-293T C578(0.91)  LDD1698  [5]
 LDCM0468  Fragment33 PaTu 8988t C193(0.83)  LDD1347  [1]
 LDCM0427  Fragment51 HCT 116 C193(2.49)  LDD0744  [1]
 LDCM0022  KB02 22RV1 C578(2.63)  LDD2243  [6]
 LDCM0023  KB03 22RV1 C578(3.84)  LDD2660  [6]
 LDCM0024  KB05 SKMEL24 C193(1.72)  LDD3323  [6]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Peptidyl-prolyl cis-trans isomerase H (PPIH) Cyclophilin-type PPIase family O43447
Peptidyl-prolyl cis-trans isomerase-like 1 (PPIL1) Cyclophilin-type PPIase family Q9Y3C6
Transcription factor
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Homeobox protein Hox-A1 (HOXA1) Antp homeobox family P49639
Other
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
N-alpha-acetyltransferase 38, NatC auxiliary subunit (NAA38) SnRNP Sm proteins family Q9BRA0
Rhombotin-2 (LMO2) . P25791

References

1 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
2 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
3 Multiplexed CuAAC Suzuki-Miyaura Labeling for Tandem Activity-Based Chemoproteomic Profiling. Anal Chem. 2021 Feb 2;93(4):2610-2618. doi: 10.1021/acs.analchem.0c04726. Epub 2021 Jan 20.
Mass spectrometry data entry: PXD022279
4 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
5 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
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Mass spectrometry data entry: PXD047840