Details of the Target

General Information of Target

Target ID LDTP09511
Target Name Guanine nucleotide exchange protein SMCR8 (SMCR8)
Gene Name SMCR8
Gene ID 140775
Synonyms
Guanine nucleotide exchange protein SMCR8; Smith-Magenis syndrome chromosomal region candidate gene 8 protein
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MISAPDVVAFTKEEEYEEEPYNEPALPEEYSVPLFPFASQGANPWSKLSGAKFSRDFILI
SEFSEQVGPQPLLTIPNDTKVFGTFDLNYFSLRIMSVDYQASFVGHPPGSAYPKLNFVED
SKVVLGDSKEGAFAYVHHLTLYDLEARGFVRPFCMAYISADQHKIMQQFQELSAEFSRAS
ECLKTGNRKAFAGELEKKLKDLDYTRTVLHTETEIQKKANDKGFYSSQAIEKANELASVE
KSIIEHQDLLKQIRSYPHRKLKGHDLCPGEMEHIQDQASQASTTSNPDESADTDLYTCRP
AYTPKLIKAKSTKCFDKKLKTLEELCDTEYFTQTLAQLSHIEHMFRGDLCYLLTSQIDRA
LLKQQHITNFLFEDFVEVDDRMVEKQESIPSKPSQDRPPSSSLEECPIPKVLISVGSYKS
SVESVLIKMEQELGDEEYKEVEVTELSSFDPQENLDYLDMDMKGSISSGESIEVLGTEKS
TSVLSKSDSQASLTVPLSPQVVRSKAVSHRTISEDSIEVLSTCPSEALIPDDFKASYPSA
INEEESYPDGNEGAIRFQASISPPELGETEEGSIENTPSQIDSSCCIGKESDGQLVLPST
PAHTHSDEDGVVSSPPQRHRQKDQGFRVDFSVENANPSSRDNSCEGFPAYELDPSHLLAS
RDISKTSLDNYSDTTSYVSSVASTSSDRIPSAYPAGLSSDRHKKRAGQNALKFIRQYPFA
HPAIYSLLSGRTLVVLGEDEAIVRKLVTALAIFVPSYGCYAKPVKHWASSPLHIMDFQKW
KLIGLQRVASPAGAGTLHALSRYSRYTSILDLDNKTLRCPLYRGTLVPRLADHRTQIKRG
STYYLHVQSMLTQLCSKAFLYTFCHHLHLPTHDKETEELVASRQMSFLKLTLGLVNEDVR
VVQYLAELLKLHYMQESPGTSHPMLRFDYVPSFLYKI
Target Bioclass
Other
Family
SMCR8 family
Subcellular location
Cytoplasm
Function
Component of the C9orf72-SMCR8 complex, a complex that has guanine nucleotide exchange factor (GEF) activity and regulates autophagy. In the complex, C9orf72 and SMCR8 probably constitute the catalytic subunits that promote the exchange of GDP to GTP, converting inactive GDP-bound RAB8A and RAB39B into their active GTP-bound form, thereby promoting autophagosome maturation. The C9orf72-SMCR8 complex also acts as a negative regulator of autophagy initiation by interacting with the ULK1/ATG1 kinase complex and inhibiting its protein kinase activity. As part of the C9orf72-SMCR8 complex, stimulates RAB8A and RAB11A GTPase activity in vitro. Acts as a regulator of mTORC1 signaling by promoting phosphorylation of mTORC1 substrates. In addition to its activity in the cytoplasm within the C9orf72-SMCR8 complex, SMCR8 also localizes in the nucleus, where it associates with chromatin and negatively regulates expression of suppresses ULK1 and WIPI2 genes.
Uniprot ID
Q8TEV9
Ensemble ID
ENST00000406438.5
HGNC ID
HGNC:17921

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
COLO320 SNV: p.S660N .
DU145 SNV: p.L800M .
HCT116 SNV: p.V136M .
HT SNV: p.Y256C .
HT115 SNV: p.E175K; p.E405K .
KMCH1 SNV: p.A132T .
MDST8 SNV: p.S770Y .
MEWO SNV: p.S639F .
MFE319 SNV: p.S468G .
TOV21G SNV: p.P601T .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 6 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
STPyne
 Probe Info  		K712(0.88)  LDD0277  [1]
DBIA
 Probe Info  		C350(1.34)  LDD3338  [2]
Acrolein
 Probe Info  		N.A.  LDD0232  [3]
IA-alkyne
 Probe Info  		N.A.  LDD0165  [4]
NAIA_4
 Probe Info  		N.A.  LDD2226  [5]
AOyne
 Probe Info  		15.00  LDD0443  [6]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HEK-293T C406(1.04); C523(1.10); C759(1.05)  LDD1507  [7]
 LDCM0215  AC10 HEK-293T C406(1.05); C523(1.11); C759(1.04)  LDD1508  [7]
 LDCM0216  AC100 HEK-293T C350(1.08)  LDD0814  [8]
 LDCM0217  AC101 HEK-293T C350(1.03)  LDD0815  [8]
 LDCM0218  AC102 HEK-293T C350(1.20)  LDD0816  [8]
 LDCM0219  AC103 HEK-293T C350(1.37)  LDD0817  [8]
 LDCM0220  AC104 HEK-293T C350(1.17)  LDD0818  [8]
 LDCM0221  AC105 HEK-293T C350(1.14)  LDD0819  [8]
 LDCM0222  AC106 HEK-293T C350(1.19)  LDD0820  [8]
 LDCM0223  AC107 HEK-293T C350(1.15)  LDD0821  [8]
 LDCM0224  AC108 HEK-293T C350(1.08)  LDD0822  [8]
 LDCM0225  AC109 HEK-293T C350(1.03)  LDD0823  [8]
 LDCM0226  AC11 HEK-293T C406(1.14); C523(0.98); C759(0.99); C350(0.99)  LDD1509  [7]
 LDCM0227  AC110 HEK-293T C350(1.23)  LDD0825  [8]
 LDCM0228  AC111 HEK-293T C350(1.03)  LDD0826  [8]
 LDCM0229  AC112 HEK-293T C350(1.14)  LDD0827  [8]
 LDCM0237  AC12 HEK-293T C406(1.09); C523(0.90); C759(0.99)  LDD1510  [7]
 LDCM0246  AC128 HEK-293T C267(1.75); C298(1.75)  LDD0844  [8]
 LDCM0247  AC129 HEK-293T C267(2.71); C298(2.71)  LDD0845  [8]
 LDCM0249  AC130 HEK-293T C267(2.64); C298(2.64)  LDD0847  [8]
 LDCM0250  AC131 HEK-293T C267(1.40); C298(1.40)  LDD0848  [8]
 LDCM0251  AC132 HEK-293T C267(2.20); C298(2.20)  LDD0849  [8]
 LDCM0252  AC133 HEK-293T C267(2.37); C298(2.37)  LDD0850  [8]
 LDCM0253  AC134 HEK-293T C267(1.81); C298(1.81)  LDD0851  [8]
 LDCM0254  AC135 HEK-293T C267(1.34); C298(1.34)  LDD0852  [8]
 LDCM0255  AC136 HEK-293T C267(1.01); C298(1.01)  LDD0853  [8]
 LDCM0256  AC137 HEK-293T C267(1.28); C298(1.28)  LDD0854  [8]
 LDCM0257  AC138 HEK-293T C267(1.28); C298(1.28)  LDD0855  [8]
 LDCM0258  AC139 HEK-293T C267(1.74); C298(1.74)  LDD0856  [8]
 LDCM0259  AC14 HEK-293T C406(1.15); C523(0.99); C759(0.96); C644(0.96)  LDD1512  [7]
 LDCM0260  AC140 HEK-293T C267(1.64); C298(1.64)  LDD0858  [8]
 LDCM0261  AC141 HEK-293T C267(1.22); C298(1.22)  LDD0859  [8]
 LDCM0262  AC142 HEK-293T C267(1.47); C298(1.47)  LDD0860  [8]
 LDCM0263  AC143 HEK-293T C267(1.13); C298(1.13); C350(1.14)  LDD0861  [8]
 LDCM0264  AC144 HEK-293T C267(0.93); C298(0.93); C350(1.02)  LDD0862  [8]
 LDCM0265  AC145 HEK-293T C267(1.34); C298(1.34); C350(1.03)  LDD0863  [8]
 LDCM0266  AC146 HEK-293T C267(0.81); C298(0.81); C350(1.11)  LDD0864  [8]
 LDCM0267  AC147 HEK-293T C267(0.49); C298(0.49); C350(1.10)  LDD0865  [8]
 LDCM0268  AC148 HEK-293T C267(1.31); C298(1.31); C350(1.14)  LDD0866  [8]
 LDCM0269  AC149 HEK-293T C267(1.01); C298(1.01); C350(1.12)  LDD0867  [8]
 LDCM0270  AC15 HEK-293T C523(1.15); C759(0.94)  LDD1513  [7]
 LDCM0271  AC150 HEK-293T C267(1.23); C298(1.23); C350(1.23)  LDD0869  [8]
 LDCM0272  AC151 HEK-293T C267(1.82); C298(1.82); C350(1.03)  LDD0870  [8]
 LDCM0273  AC152 HEK-293T C267(0.71); C298(0.71); C350(1.07)  LDD0871  [8]
 LDCM0274  AC153 HEK-293T C267(0.73); C298(0.73); C350(1.08)  LDD0872  [8]
 LDCM0621  AC154 HEK-293T C267(0.68); C298(0.68); C350(1.14)  LDD2162  [8]
 LDCM0622  AC155 HEK-293T C267(1.41); C298(1.41); C350(0.98)  LDD2163  [8]
 LDCM0623  AC156 HEK-293T C267(1.16); C298(1.16); C350(1.10)  LDD2164  [8]
 LDCM0624  AC157 HEK-293T C267(0.52); C298(0.52); C350(1.28)  LDD2165  [8]
 LDCM0276  AC17 HEK-293T C406(1.12); C523(1.00); C759(0.98)  LDD1515  [7]
 LDCM0277  AC18 HEK-293T C406(1.00); C523(1.03); C759(0.96)  LDD1516  [7]
 LDCM0278  AC19 HEK-293T C406(1.43); C523(0.86); C759(0.88); C350(0.86)  LDD1517  [7]
 LDCM0279  AC2 HEK-293T C406(1.15); C523(1.11); C759(0.94)  LDD1518  [7]
 LDCM0280  AC20 HEK-293T C406(1.00); C523(0.94); C759(0.98)  LDD1519  [7]
 LDCM0281  AC21 HEK-293T C406(1.06); C523(1.04); C759(0.92)  LDD1520  [7]
 LDCM0282  AC22 HEK-293T C406(1.08); C523(1.00); C759(1.21); C644(1.13)  LDD1521  [7]
 LDCM0283  AC23 HEK-293T C523(0.99); C759(1.01)  LDD1522  [7]
 LDCM0284  AC24 HEK-293T C523(1.01); C759(0.93); C644(1.00)  LDD1523  [7]
 LDCM0285  AC25 HEK-293T C267(0.93)  LDD0883  [8]
 LDCM0286  AC26 HEK-293T C267(0.90)  LDD0884  [8]
 LDCM0287  AC27 HEK-293T C267(0.99)  LDD0885  [8]
 LDCM0288  AC28 HEK-293T C267(0.93)  LDD0886  [8]
 LDCM0289  AC29 HEK-293T C267(1.02)  LDD0887  [8]
 LDCM0290  AC3 HEK-293T C406(1.15); C523(0.98); C759(1.09); C350(1.14)  LDD1529  [7]
 LDCM0291  AC30 HEK-293T C267(1.00)  LDD0889  [8]
 LDCM0292  AC31 HEK-293T C267(0.89)  LDD0890  [8]
 LDCM0293  AC32 HEK-293T C267(0.92)  LDD0891  [8]
 LDCM0294  AC33 HEK-293T C267(0.94)  LDD0892  [8]
 LDCM0295  AC34 HEK-293T C267(0.97)  LDD0893  [8]
 LDCM0296  AC35 HEK-293T C406(1.22); C523(0.90); C759(0.97); C350(1.06)  LDD1535  [7]
 LDCM0297  AC36 HEK-293T C406(1.04); C523(0.89); C759(0.99)  LDD1536  [7]
 LDCM0298  AC37 HEK-293T C406(1.08); C523(1.12); C759(0.93)  LDD1537  [7]
 LDCM0299  AC38 HEK-293T C406(1.13); C523(1.05); C759(0.99); C644(1.01)  LDD1538  [7]
 LDCM0300  AC39 HEK-293T C523(1.01); C759(0.85)  LDD1539  [7]
 LDCM0301  AC4 HEK-293T C406(1.07); C523(0.90); C759(1.08)  LDD1540  [7]
 LDCM0302  AC40 HEK-293T C523(1.09); C759(0.98); C644(1.02)  LDD1541  [7]
 LDCM0303  AC41 HEK-293T C406(1.09); C523(0.97); C759(1.05)  LDD1542  [7]
 LDCM0304  AC42 HEK-293T C406(1.16); C523(1.10); C759(1.07)  LDD1543  [7]
 LDCM0305  AC43 HEK-293T C406(1.08); C523(1.06); C759(0.92); C350(1.14)  LDD1544  [7]
 LDCM0306  AC44 HEK-293T C406(0.99); C523(1.06); C759(1.02)  LDD1545  [7]
 LDCM0307  AC45 HEK-293T C406(1.13); C523(1.05); C759(0.97)  LDD1546  [7]
 LDCM0308  AC46 HEK-293T C298(0.98); C350(1.28)  LDD0906  [8]
 LDCM0309  AC47 HEK-293T C298(0.94); C350(1.02)  LDD0907  [8]
 LDCM0310  AC48 HEK-293T C298(0.97); C350(0.99)  LDD0908  [8]
 LDCM0311  AC49 HEK-293T C298(1.05); C350(1.17)  LDD0909  [8]
 LDCM0312  AC5 HEK-293T C406(1.07); C523(1.01); C759(0.92)  LDD1551  [7]
 LDCM0313  AC50 HEK-293T C298(0.94); C350(1.03)  LDD0911  [8]
 LDCM0314  AC51 HEK-293T C298(0.73); C350(0.94)  LDD0912  [8]
 LDCM0315  AC52 HEK-293T C298(1.11); C350(1.01)  LDD0913  [8]
 LDCM0316  AC53 HEK-293T C298(0.66); C350(1.05)  LDD0914  [8]
 LDCM0317  AC54 HEK-293T C298(0.76); C350(1.14)  LDD0915  [8]
 LDCM0318  AC55 HEK-293T C298(0.86); C350(1.04)  LDD0916  [8]
 LDCM0319  AC56 HEK-293T C298(0.98); C350(1.21)  LDD0917  [8]
 LDCM0320  AC57 HEK-293T C267(0.45); C298(0.54); C350(1.17)  LDD0918  [8]
 LDCM0321  AC58 HEK-293T C267(0.40); C298(0.53); C350(1.02)  LDD0919  [8]
 LDCM0322  AC59 HEK-293T C267(0.29); C298(0.56); C350(1.17)  LDD0920  [8]
 LDCM0323  AC6 HEK-293T C406(1.16); C523(1.09); C759(1.08); C644(1.00)  LDD1562  [7]
 LDCM0324  AC60 HEK-293T C267(0.30); C298(0.37); C350(1.24)  LDD0922  [8]
 LDCM0325  AC61 HEK-293T C267(0.30); C298(0.75); C350(1.14)  LDD0923  [8]
 LDCM0326  AC62 HEK-293T C267(0.26); C298(0.50); C350(0.97)  LDD0924  [8]
 LDCM0327  AC63 HEK-293T C267(0.27); C298(0.45); C350(0.96)  LDD0925  [8]
 LDCM0328  AC64 HEK-293T C267(0.32); C298(0.46); C350(1.00)  LDD0926  [8]
 LDCM0329  AC65 HEK-293T C267(0.33); C298(0.46); C350(0.98)  LDD0927  [8]
 LDCM0330  AC66 HEK-293T C267(0.34); C298(0.51); C350(1.11)  LDD0928  [8]
 LDCM0331  AC67 HEK-293T C267(0.42); C298(0.50); C350(0.99)  LDD0929  [8]
 LDCM0334  AC7 HEK-293T C523(0.95); C759(0.97)  LDD1568  [7]
 LDCM0345  AC8 HEK-293T C523(0.96); C759(0.93); C644(1.05)  LDD1569  [7]
 LDCM0349  AC83 HEK-293T C267(1.89); C298(1.89); C350(1.16)  LDD0947  [8]
 LDCM0350  AC84 HEK-293T C267(1.10); C298(1.10); C350(1.15)  LDD0948  [8]
 LDCM0351  AC85 HEK-293T C267(1.51); C298(1.51); C350(1.29)  LDD0949  [8]
 LDCM0352  AC86 HEK-293T C267(2.23); C298(2.23); C350(1.08)  LDD0950  [8]
 LDCM0353  AC87 HEK-293T C267(1.66); C298(1.66); C350(1.14)  LDD0951  [8]
 LDCM0354  AC88 HEK-293T C267(1.58); C298(1.58); C350(1.33)  LDD0952  [8]
 LDCM0355  AC89 HEK-293T C267(1.44); C298(1.44); C350(1.04)  LDD0953  [8]
 LDCM0357  AC90 HEK-293T C267(1.69); C298(1.69); C350(1.13)  LDD0955  [8]
 LDCM0358  AC91 HEK-293T C267(1.40); C298(1.40); C350(1.01)  LDD0956  [8]
 LDCM0359  AC92 HEK-293T C267(1.03); C298(1.03); C350(1.07)  LDD0957  [8]
 LDCM0360  AC93 HEK-293T C267(0.88); C298(0.88); C350(1.02)  LDD0958  [8]
 LDCM0361  AC94 HEK-293T C267(1.37); C298(1.37); C350(1.11)  LDD0959  [8]
 LDCM0362  AC95 HEK-293T C267(0.96); C298(0.96); C350(1.20)  LDD0960  [8]
 LDCM0363  AC96 HEK-293T C267(2.35); C298(2.35); C350(1.07)  LDD0961  [8]
 LDCM0364  AC97 HEK-293T C267(0.92); C298(0.92); C350(1.04)  LDD0962  [8]
 LDCM0365  AC98 HEK-293T C350(1.06)  LDD0963  [8]
 LDCM0366  AC99 HEK-293T C350(0.95)  LDD0964  [8]
 LDCM0248  AKOS034007472 HEK-293T C406(1.00); C523(1.12); C759(0.93)  LDD1511  [7]
 LDCM0356  AKOS034007680 HEK-293T C406(1.09); C523(1.02); C759(1.02)  LDD1570  [7]
 LDCM0275  AKOS034007705 HEK-293T C523(1.03); C759(0.95); C644(1.01)  LDD1514  [7]
 LDCM0630  CCW28-3 231MFP C523(0.91)  LDD2214  [9]
 LDCM0367  CL1 HEK-293T C406(1.10); C523(1.04); C759(1.06)  LDD1571  [7]
 LDCM0368  CL10 HEK-293T C406(1.15); C523(1.00); C759(1.08); C644(1.28)  LDD1572  [7]
 LDCM0369  CL100 HEK-293T C523(1.01); C759(0.99); C350(1.03)  LDD1573  [7]
 LDCM0370  CL101 HEK-293T C406(1.04); C523(0.96); C759(1.12)  LDD1574  [7]
 LDCM0371  CL102 HEK-293T C406(1.04); C523(0.92); C759(0.92); C350(1.01)  LDD1575  [7]
 LDCM0372  CL103 HEK-293T C406(1.01); C523(1.06); C759(0.93)  LDD1576  [7]
 LDCM0373  CL104 HEK-293T C523(0.91); C759(0.98); C350(0.99)  LDD1577  [7]
 LDCM0374  CL105 HEK-293T C406(1.04); C523(1.07); C759(1.01)  LDD1578  [7]
 LDCM0375  CL106 HEK-293T C406(1.07); C523(0.94); C759(0.98); C350(1.04)  LDD1579  [7]
 LDCM0376  CL107 HEK-293T C406(1.02); C523(1.02); C759(0.87)  LDD1580  [7]
 LDCM0377  CL108 HEK-293T C523(0.89); C759(0.93); C350(0.98)  LDD1581  [7]
 LDCM0378  CL109 HEK-293T C406(1.01); C523(0.90); C759(0.98)  LDD1582  [7]
 LDCM0379  CL11 HEK-293T C523(1.11); C759(1.10)  LDD1583  [7]
 LDCM0380  CL110 HEK-293T C406(1.00); C523(0.79); C759(0.81); C350(1.08)  LDD1584  [7]
 LDCM0381  CL111 HEK-293T C406(0.95); C523(1.05); C759(0.98)  LDD1585  [7]
 LDCM0382  CL112 HEK-293T C267(0.87)  LDD0980  [8]
 LDCM0383  CL113 HEK-293T C267(0.86)  LDD0981  [8]
 LDCM0384  CL114 HEK-293T C267(0.93)  LDD0982  [8]
 LDCM0385  CL115 HEK-293T C267(0.96)  LDD0983  [8]
 LDCM0386  CL116 HEK-293T C267(0.99)  LDD0984  [8]
 LDCM0387  CL117 HEK-293T C406(1.14); C523(1.18); C759(1.05)  LDD1591  [7]
 LDCM0388  CL118 HEK-293T C406(1.12); C523(1.01); C759(0.88); C350(0.90)  LDD1592  [7]
 LDCM0389  CL119 HEK-293T C406(1.01); C523(1.14); C759(0.93)  LDD1593  [7]
 LDCM0390  CL12 HEK-293T C523(0.99); C759(1.13); C644(1.08)  LDD1594  [7]
 LDCM0391  CL120 HEK-293T C523(0.95); C759(1.02); C350(1.04)  LDD1595  [7]
 LDCM0392  CL121 HEK-293T C298(0.94); C350(1.03)  LDD0990  [8]
 LDCM0393  CL122 HEK-293T C298(0.97); C350(1.10)  LDD0991  [8]
 LDCM0394  CL123 HEK-293T C298(0.93); C350(1.04)  LDD0992  [8]
 LDCM0395  CL124 HEK-293T C298(0.81); C350(1.17)  LDD0993  [8]
 LDCM0396  CL125 HEK-293T C267(0.60); C298(0.65); C350(1.13)  LDD0994  [8]
 LDCM0397  CL126 HEK-293T C267(0.60); C298(0.61); C350(1.11)  LDD0995  [8]
 LDCM0398  CL127 HEK-293T C267(0.52); C298(0.56); C350(0.95)  LDD0996  [8]
 LDCM0399  CL128 HEK-293T C267(0.62); C298(0.76); C350(1.07)  LDD0997  [8]
 LDCM0400  CL13 HEK-293T C406(1.21); C523(1.01); C759(1.13)  LDD1604  [7]
 LDCM0401  CL14 HEK-293T C406(0.90); C523(0.98); C759(0.91); C350(1.08)  LDD1605  [7]
 LDCM0402  CL15 HEK-293T C406(0.98); C523(0.98); C759(0.90)  LDD1606  [7]
 LDCM0403  CL16 HEK-293T C523(0.88); C759(0.88); C350(1.08)  LDD1607  [7]
 LDCM0404  CL17 HEK-293T C406(1.09); C523(1.07); C759(0.98)  LDD1608  [7]
 LDCM0405  CL18 HEK-293T C406(1.08); C523(1.04); C759(0.90)  LDD1609  [7]
 LDCM0406  CL19 HEK-293T C406(1.10); C523(1.01); C759(1.02); C350(1.20)  LDD1610  [7]
 LDCM0407  CL2 HEK-293T C406(1.08); C523(1.06); C759(0.88); C350(1.10)  LDD1611  [7]
 LDCM0408  CL20 HEK-293T C406(1.23); C523(1.13); C759(1.07)  LDD1612  [7]
 LDCM0409  CL21 HEK-293T C406(0.95); C523(1.01); C759(1.04)  LDD1613  [7]
 LDCM0410  CL22 HEK-293T C406(0.95); C523(1.12); C759(1.05); C644(1.12)  LDD1614  [7]
 LDCM0411  CL23 HEK-293T C523(1.03); C759(1.09)  LDD1615  [7]
 LDCM0412  CL24 HEK-293T C523(1.03); C759(1.05); C644(0.95)  LDD1616  [7]
 LDCM0413  CL25 HEK-293T C406(1.09); C523(1.04); C759(1.06)  LDD1617  [7]
 LDCM0414  CL26 HEK-293T C406(1.13); C523(0.96); C759(1.01); C350(0.97)  LDD1618  [7]
 LDCM0415  CL27 HEK-293T C406(1.06); C523(1.15); C759(0.87)  LDD1619  [7]
 LDCM0416  CL28 HEK-293T C523(0.87); C759(0.91); C350(0.85)  LDD1620  [7]
 LDCM0417  CL29 HEK-293T C406(1.06); C523(1.12); C759(0.99)  LDD1621  [7]
 LDCM0418  CL3 HEK-293T C406(0.93); C523(1.09); C759(0.91)  LDD1622  [7]
 LDCM0419  CL30 HEK-293T C406(1.00); C523(1.05); C759(0.88)  LDD1623  [7]
 LDCM0420  CL31 HEK-293T C406(1.05); C523(0.92); C759(0.92); C350(0.98)  LDD1624  [7]
 LDCM0421  CL32 HEK-293T C406(1.12); C523(0.93); C759(1.10)  LDD1625  [7]
 LDCM0422  CL33 HEK-293T C406(0.88); C523(0.99); C759(0.84)  LDD1626  [7]
 LDCM0423  CL34 HEK-293T C406(0.92); C523(1.21); C759(1.10); C644(1.14)  LDD1627  [7]
 LDCM0424  CL35 HEK-293T C523(1.14); C759(0.95)  LDD1628  [7]
 LDCM0425  CL36 HEK-293T C523(1.03); C759(1.09); C644(1.04)  LDD1629  [7]
 LDCM0426  CL37 HEK-293T C406(1.07); C523(0.85); C759(1.08)  LDD1630  [7]
 LDCM0428  CL39 HEK-293T C406(1.01); C523(0.99); C759(0.88)  LDD1632  [7]
 LDCM0429  CL4 HEK-293T C523(0.92); C759(0.94); C350(1.06)  LDD1633  [7]
 LDCM0430  CL40 HEK-293T C523(0.98); C759(0.91); C350(0.99)  LDD1634  [7]
 LDCM0431  CL41 HEK-293T C406(1.00); C523(0.78); C759(1.03)  LDD1635  [7]
 LDCM0432  CL42 HEK-293T C406(0.93); C523(1.06); C759(1.12)  LDD1636  [7]
 LDCM0433  CL43 HEK-293T C406(1.00); C523(1.12); C759(0.95); C350(1.07)  LDD1637  [7]
 LDCM0434  CL44 HEK-293T C406(1.08); C523(1.02); C759(0.97)  LDD1638  [7]
 LDCM0435  CL45 HEK-293T C406(0.90); C523(1.07); C759(0.96)  LDD1639  [7]
 LDCM0436  CL46 HEK-293T C406(0.88); C523(1.10); C759(0.99); C644(0.94)  LDD1640  [7]
 LDCM0437  CL47 HEK-293T C523(0.96); C759(1.01)  LDD1641  [7]
 LDCM0438  CL48 HEK-293T C523(1.10); C759(1.08); C644(1.13)  LDD1642  [7]
 LDCM0439  CL49 HEK-293T C406(1.17); C523(0.89); C759(1.06)  LDD1643  [7]
 LDCM0440  CL5 HEK-293T C406(1.22); C523(0.98); C759(1.14)  LDD1644  [7]
 LDCM0441  CL50 HEK-293T C406(0.99); C523(0.95); C759(0.95); C350(0.79)  LDD1645  [7]
 LDCM0443  CL52 HEK-293T C523(0.93); C759(1.06); C350(1.01)  LDD1646  [7]
 LDCM0444  CL53 HEK-293T C406(1.08); C523(1.15); C759(0.91)  LDD1647  [7]
 LDCM0445  CL54 HEK-293T C406(1.06); C523(0.92); C759(0.68)  LDD1648  [7]
 LDCM0446  CL55 HEK-293T C406(1.11); C523(0.97); C759(1.01); C350(1.05)  LDD1649  [7]
 LDCM0447  CL56 HEK-293T C406(1.13); C523(0.95); C759(0.96)  LDD1650  [7]
 LDCM0448  CL57 HEK-293T C406(0.98); C523(1.19); C759(0.88)  LDD1651  [7]
 LDCM0449  CL58 HEK-293T C406(0.82); C523(1.19); C759(1.01); C644(1.04)  LDD1652  [7]
 LDCM0450  CL59 HEK-293T C523(1.02); C759(1.16)  LDD1653  [7]
 LDCM0451  CL6 HEK-293T C406(1.08); C523(1.03); C759(1.11)  LDD1654  [7]
 LDCM0452  CL60 HEK-293T C523(0.96); C759(1.06); C644(1.08)  LDD1655  [7]
 LDCM0453  CL61 HEK-293T C267(1.06); C298(1.06)  LDD1051  [8]
 LDCM0454  CL62 HEK-293T C267(1.28); C298(1.28)  LDD1052  [8]
 LDCM0455  CL63 HEK-293T C267(0.91); C298(0.91)  LDD1053  [8]
 LDCM0456  CL64 HEK-293T C267(2.99); C298(2.99)  LDD1054  [8]
 LDCM0457  CL65 HEK-293T C267(1.46); C298(1.46)  LDD1055  [8]
 LDCM0458  CL66 HEK-293T C267(1.27); C298(1.27)  LDD1056  [8]
 LDCM0459  CL67 HEK-293T C267(1.28); C298(1.28)  LDD1057  [8]
 LDCM0460  CL68 HEK-293T C267(2.17); C298(2.17)  LDD1058  [8]
 LDCM0461  CL69 HEK-293T C267(1.42); C298(1.42)  LDD1059  [8]
 LDCM0462  CL7 HEK-293T C406(1.09); C523(0.91); C759(1.05); C350(1.10)  LDD1665  [7]
 LDCM0463  CL70 HEK-293T C267(1.48); C298(1.48)  LDD1061  [8]
 LDCM0464  CL71 HEK-293T C267(1.71); C298(1.71)  LDD1062  [8]
 LDCM0465  CL72 HEK-293T C267(2.04); C298(2.04)  LDD1063  [8]
 LDCM0466  CL73 HEK-293T C267(2.16); C298(2.16)  LDD1064  [8]
 LDCM0467  CL74 HEK-293T C267(1.44); C298(1.44)  LDD1065  [8]
 LDCM0469  CL76 HEK-293T C523(1.10); C759(1.04); C350(0.86)  LDD1672  [7]
 LDCM0470  CL77 HEK-293T C406(0.98); C523(0.59); C759(1.00)  LDD1673  [7]
 LDCM0471  CL78 HEK-293T C406(1.02); C523(1.15); C759(0.99)  LDD1674  [7]
 LDCM0472  CL79 HEK-293T C406(1.05); C523(1.03); C759(0.95); C350(1.12)  LDD1675  [7]
 LDCM0473  CL8 HEK-293T C406(1.16); C523(0.81); C759(0.93)  LDD1676  [7]
 LDCM0474  CL80 HEK-293T C406(1.15); C523(1.06); C759(0.95)  LDD1677  [7]
 LDCM0475  CL81 HEK-293T C406(0.95); C523(1.13); C759(1.06)  LDD1678  [7]
 LDCM0476  CL82 HEK-293T C406(0.93); C523(1.13); C759(0.94); C644(1.17)  LDD1679  [7]
 LDCM0477  CL83 HEK-293T C523(0.91); C759(0.98)  LDD1680  [7]
 LDCM0478  CL84 HEK-293T C523(0.92); C759(1.01); C644(1.06)  LDD1681  [7]
 LDCM0479  CL85 HEK-293T C406(1.15); C523(0.98); C759(1.19)  LDD1682  [7]
 LDCM0480  CL86 HEK-293T C406(1.14); C523(0.99); C759(1.05); C350(1.08)  LDD1683  [7]
 LDCM0481  CL87 HEK-293T C406(1.10); C523(1.15); C759(0.93)  LDD1684  [7]
 LDCM0482  CL88 HEK-293T C523(0.96); C759(1.07); C350(1.02)  LDD1685  [7]
 LDCM0483  CL89 HEK-293T C406(1.03); C523(1.03); C759(1.07)  LDD1686  [7]
 LDCM0484  CL9 HEK-293T C406(0.93); C523(1.17); C759(1.01)  LDD1687  [7]
 LDCM0485  CL90 HEK-293T C406(1.18); C523(0.98); C759(0.99)  LDD1688  [7]
 LDCM0486  CL91 HEK-293T C406(1.16); C523(1.12); C759(1.02); C350(0.96)  LDD1689  [7]
 LDCM0487  CL92 HEK-293T C406(1.18); C523(0.96); C759(0.99)  LDD1690  [7]
 LDCM0488  CL93 HEK-293T C406(1.02); C523(1.00); C759(0.90)  LDD1691  [7]
 LDCM0489  CL94 HEK-293T C406(0.94); C523(1.16); C759(1.01); C644(1.25)  LDD1692  [7]
 LDCM0490  CL95 HEK-293T C523(0.97); C759(1.01)  LDD1693  [7]
 LDCM0491  CL96 HEK-293T C523(1.14); C759(1.07); C644(0.95)  LDD1694  [7]
 LDCM0492  CL97 HEK-293T C406(1.14); C523(0.94); C759(1.08)  LDD1695  [7]
 LDCM0493  CL98 HEK-293T C406(0.99); C523(0.92); C759(1.01); C350(0.76)  LDD1696  [7]
 LDCM0494  CL99 HEK-293T C406(0.98); C523(1.07); C759(0.91)  LDD1697  [7]
 LDCM0495  E2913 HEK-293T C406(1.10); C523(1.13); C759(0.97)  LDD1698  [7]
 LDCM0468  Fragment33 HEK-293T C267(1.77); C298(1.77)  LDD1066  [8]
 LDCM0427  Fragment51 HEK-293T C406(1.06); C523(0.95); C759(0.88); C350(0.82)  LDD1631  [7]
 LDCM0022  KB02 HEK-293T C406(1.03); C759(1.01); C523(1.12)  LDD1492  [7]
 LDCM0023  KB03 HEK-293T C406(0.92); C759(0.95); C523(1.15)  LDD1497  [7]
 LDCM0024  KB05 MV4-11 C350(1.34)  LDD3338  [2]
 LDCM0109  NEM HeLa N.A.  LDD0232  [3]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Other
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Guanine nucleotide exchange factor C9orf72 (C9orf72) . Q96LT7

References

1 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
2 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
3 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
4 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
5 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
6 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
7 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
8 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
9 Covalent Ligand Screening Uncovers a RNF4 E3 Ligase Recruiter for Targeted Protein Degradation Applications. ACS Chem Biol. 2019 Nov 15;14(11):2430-2440. doi: 10.1021/acschembio.8b01083. Epub 2019 May 13.