Details of the Target

General Information of Target

Target ID LDTP09483
Target Name MORC family CW-type zinc finger protein 4 (MORC4)
Gene Name MORC4
Gene ID 79710
Synonyms
ZCW4; ZCWCC2; MORC family CW-type zinc finger protein 4; Zinc finger CW-type coiled-coil domain protein 2; Zinc finger CW-type domain protein 4
3D Structure
Download
2D Sequence (FASTA)
Download
3D Structure (PDB)
Download
Sequence
MLLYRGAPAGPGAPGCGLARPGGGPQAFGIRLSTMSPRYLQSNSSSHTRPFSAIAELLDN
AVDPDVSARTVFIDVEEVKNKSCLTFTDDGCGMTPHKLHRMLSFGFTDKVIKKSQCPIGV
FGNGFKSGSMRLGKDALVFTKNGGTLTVGLLSQTYLECVQAQAVIVPIVPFNQQNKKMII
TEDSLPSLEAILNYSIFNRENDLLAQFDAIPGKKGTRVLIWNIRRNKNGKSELDFDTDQY
DILVSDFDTEEKMTGGVTSELPETEYSLRAFCGILYMKPRMKIFLRQKKVTTQMIAKSLA
NVEYDTYKPTFTNKQVRITFGFSCKNSNQFGIMMYHNNRLIKSFEKVGCQVKPTRGEGVG
VIGVIECNFLKPAYNKQDFEYTKEYRLTINALAQKLNAYWKEKTSQDNFETSTVARPIPK
VPDQTWVQCDECLKWRKLPGKIDPSMLPARWFCYYNSHPKYRRCSVPEEQELTDEDLCLS
KAKKQEQTVEEKKKMPMENENHQVFSNPPKILTVQEMAGLNNKTIGYEGIHSPSVLPSGG
EESRSPSLQLKPLDSSVLQFSSKYKWILGEEPVEKRRRLQNEMTTPSLDYSMPAPYRRVE
APVAYPEGENSHDKSSSERSTPPYLFPEYPEASKNTGQNREVSILYPGAKDQRQGSLLPE
ELEDQMPRLVAEESNRGSTTINKEEVNKGPFVAVVGVAKGVRDSGAPIQLIPFNREELAE
RRKAVESWNPVPYSVASAAIPAAAIGEKARGYEESEGHNTPKLKNQRELEELKRTTEKLE
RVLAERNLFQQKVEELEQERNHWQSEFKKVQHELVIYSTQEAEGLYWSKKHMGYRQAEFQ
ILKAELERTKEEKQELKEKLKETETHLEMLQKAQVSYRTPEGDDLERALAKLTRLRIHVS
YLLTSVLPHLELREIGYDSEQVDGILYTVLEANHILD
Target Bioclass
Other
Subcellular location
Nucleus
Function
Histone methylation reader which binds to non-methylated (H3K4me0), monomethylated (H3K4me1), dimethylated (H3K4me2) and trimethylated (H3K4me3) 'Lys-4' on histone H3. The order of binding preference is H3K4me3 > H3K4me2 > H3K4me1 > H3K4me0.
Uniprot ID
Q8TE76
Ensemble ID
ENST00000255495.7
HGNC ID
HGNC:23485

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
CFPAC1 SNV: p.G17W .
HEC1 SNV: p.P211T DBIA    Probe Info 
HEC1B SNV: p.P211T .
OAW28 SNV: p.Q638Ter .
TKKK SNV: p.W426Ter DBIA    Probe Info 

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 3 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C324(0.84)  LDD0531  [2]
IPM
 Probe Info  		C16(0.00); C116(0.00)  LDD2156  [3]
TFBX
 Probe Info  		N.A.  LDD0148  [4]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HCT 116 C324(0.84)  LDD0531  [2]
 LDCM0215  AC10 HCT 116 C83(0.66); C91(0.66)  LDD0532  [2]
 LDCM0216  AC100 HEK-293T C91(0.95)  LDD0814  [2]
 LDCM0217  AC101 HEK-293T C91(0.98)  LDD0815  [2]
 LDCM0218  AC102 HEK-293T C91(0.98)  LDD0816  [2]
 LDCM0219  AC103 HEK-293T C91(1.28)  LDD0817  [2]
 LDCM0220  AC104 HEK-293T C91(1.18)  LDD0818  [2]
 LDCM0221  AC105 HEK-293T C91(0.85)  LDD0819  [2]
 LDCM0222  AC106 HEK-293T C91(0.68)  LDD0820  [2]
 LDCM0223  AC107 HEK-293T C91(1.04)  LDD0821  [2]
 LDCM0224  AC108 HEK-293T C91(1.03)  LDD0822  [2]
 LDCM0225  AC109 HEK-293T C91(0.86)  LDD0823  [2]
 LDCM0226  AC11 HCT 116 C83(0.83); C91(0.83)  LDD0543  [2]
 LDCM0227  AC110 HEK-293T C91(1.41)  LDD0825  [2]
 LDCM0228  AC111 HEK-293T C91(2.35)  LDD0826  [2]
 LDCM0229  AC112 HEK-293T C91(1.79)  LDD0827  [2]
 LDCM0230  AC113 HEK-293T C83(1.15); C91(1.18)  LDD0828  [2]
 LDCM0231  AC114 HEK-293T C83(0.95); C91(1.04)  LDD0829  [2]
 LDCM0232  AC115 HEK-293T C83(0.79); C91(1.12)  LDD0830  [2]
 LDCM0233  AC116 HEK-293T C83(0.67); C91(0.93)  LDD0831  [2]
 LDCM0234  AC117 HEK-293T C83(1.18); C91(1.29)  LDD0832  [2]
 LDCM0235  AC118 HEK-293T C83(1.75); C91(1.53)  LDD0833  [2]
 LDCM0236  AC119 HEK-293T C83(1.23); C91(1.30)  LDD0834  [2]
 LDCM0237  AC12 HCT 116 C83(0.76); C91(0.76)  LDD0554  [2]
 LDCM0238  AC120 HEK-293T C83(0.79); C91(1.09)  LDD0836  [2]
 LDCM0239  AC121 HEK-293T C83(0.80); C91(1.21)  LDD0837  [2]
 LDCM0240  AC122 HEK-293T C83(0.71); C91(1.29)  LDD0838  [2]
 LDCM0241  AC123 HEK-293T C83(1.07); C91(1.50)  LDD0839  [2]
 LDCM0242  AC124 HEK-293T C83(1.14); C91(1.26)  LDD0840  [2]
 LDCM0243  AC125 HEK-293T C83(1.06); C91(1.47)  LDD0841  [2]
 LDCM0244  AC126 HEK-293T C83(0.98); C91(1.65)  LDD0842  [2]
 LDCM0245  AC127 HEK-293T C83(0.96); C91(1.82)  LDD0843  [2]
 LDCM0246  AC128 HEK-293T C91(0.98)  LDD0844  [2]
 LDCM0247  AC129 HEK-293T C91(1.33)  LDD0845  [2]
 LDCM0249  AC130 HEK-293T C91(1.23)  LDD0847  [2]
 LDCM0250  AC131 HEK-293T C91(1.19)  LDD0848  [2]
 LDCM0251  AC132 HEK-293T C91(1.23)  LDD0849  [2]
 LDCM0252  AC133 HEK-293T C91(1.40)  LDD0850  [2]
 LDCM0253  AC134 HEK-293T C91(1.39)  LDD0851  [2]
 LDCM0254  AC135 HEK-293T C91(1.39)  LDD0852  [2]
 LDCM0255  AC136 HEK-293T C91(1.36)  LDD0853  [2]
 LDCM0256  AC137 HEK-293T C91(1.87)  LDD0854  [2]
 LDCM0257  AC138 HEK-293T C91(1.98)  LDD0855  [2]
 LDCM0258  AC139 HEK-293T C91(1.77)  LDD0856  [2]
 LDCM0259  AC14 HCT 116 C83(0.83); C91(0.83)  LDD0576  [2]
 LDCM0260  AC140 HEK-293T C91(1.49)  LDD0858  [2]
 LDCM0261  AC141 HEK-293T C91(1.74)  LDD0859  [2]
 LDCM0262  AC142 HEK-293T C91(1.56)  LDD0860  [2]
 LDCM0263  AC143 HEK-293T C91(0.88)  LDD0861  [2]
 LDCM0264  AC144 HEK-293T C91(1.18)  LDD0862  [2]
 LDCM0265  AC145 HEK-293T C91(1.35)  LDD0863  [2]
 LDCM0266  AC146 HEK-293T C91(1.27)  LDD0864  [2]
 LDCM0267  AC147 HEK-293T C91(1.48)  LDD0865  [2]
 LDCM0268  AC148 HEK-293T C91(1.27)  LDD0866  [2]
 LDCM0269  AC149 HEK-293T C91(0.89)  LDD0867  [2]
 LDCM0270  AC15 HCT 116 C83(0.88); C91(0.88)  LDD0587  [2]
 LDCM0271  AC150 HEK-293T C91(1.24)  LDD0869  [2]
 LDCM0272  AC151 HEK-293T C91(1.09)  LDD0870  [2]
 LDCM0273  AC152 HEK-293T C91(1.06)  LDD0871  [2]
 LDCM0274  AC153 HEK-293T C91(1.10)  LDD0872  [2]
 LDCM0621  AC154 HEK-293T C91(0.91)  LDD2162  [2]
 LDCM0622  AC155 HEK-293T C91(1.05)  LDD2163  [2]
 LDCM0623  AC156 HEK-293T C91(1.95)  LDD2164  [2]
 LDCM0624  AC157 HEK-293T C91(2.08)  LDD2165  [2]
 LDCM0276  AC17 HCT 116 C324(1.23)  LDD0593  [2]
 LDCM0277  AC18 HCT 116 C324(1.13)  LDD0594  [2]
 LDCM0278  AC19 HCT 116 C324(1.36)  LDD0595  [2]
 LDCM0279  AC2 HCT 116 C324(0.89)  LDD0596  [2]
 LDCM0280  AC20 HCT 116 C324(1.11)  LDD0597  [2]
 LDCM0281  AC21 HCT 116 C324(1.28)  LDD0598  [2]
 LDCM0282  AC22 HCT 116 C324(1.09)  LDD0599  [2]
 LDCM0283  AC23 HCT 116 C324(1.15)  LDD0600  [2]
 LDCM0284  AC24 HCT 116 C324(1.15)  LDD0601  [2]
 LDCM0285  AC25 HEK-293T C83(1.13); C91(1.28)  LDD0883  [2]
 LDCM0286  AC26 HEK-293T C83(0.66); C91(1.50)  LDD0884  [2]
 LDCM0287  AC27 HEK-293T C83(0.82); C91(1.25)  LDD0885  [2]
 LDCM0288  AC28 HEK-293T C83(0.97); C91(1.12)  LDD0886  [2]
 LDCM0289  AC29 HEK-293T C83(0.86); C91(1.38)  LDD0887  [2]
 LDCM0290  AC3 HCT 116 C324(0.87)  LDD0607  [2]
 LDCM0291  AC30 HEK-293T C83(0.81); C91(1.58)  LDD0889  [2]
 LDCM0292  AC31 HEK-293T C83(0.77); C91(1.11)  LDD0890  [2]
 LDCM0293  AC32 HEK-293T C83(0.91); C91(1.37)  LDD0891  [2]
 LDCM0294  AC33 HEK-293T C83(1.12); C91(1.37)  LDD0892  [2]
 LDCM0295  AC34 HEK-293T C83(0.83); C91(1.27)  LDD0893  [2]
 LDCM0296  AC35 HCT 116 C83(0.94); C91(0.94); C324(1.08)  LDD0613  [2]
 LDCM0297  AC36 HCT 116 C83(0.63); C91(0.63); C324(0.83)  LDD0614  [2]
 LDCM0298  AC37 HCT 116 C83(0.80); C91(0.80); C324(0.84)  LDD0615  [2]
 LDCM0299  AC38 HCT 116 C83(0.78); C91(0.78); C324(0.79)  LDD0616  [2]
 LDCM0300  AC39 HCT 116 C83(0.85); C91(0.85); C324(0.94)  LDD0617  [2]
 LDCM0301  AC4 HCT 116 C324(0.89)  LDD0618  [2]
 LDCM0302  AC40 HCT 116 C324(0.81); C83(0.99); C91(0.99)  LDD0619  [2]
 LDCM0303  AC41 HCT 116 C83(0.81); C91(0.81); C324(0.92)  LDD0620  [2]
 LDCM0304  AC42 HCT 116 C324(0.75); C83(0.77); C91(0.77)  LDD0621  [2]
 LDCM0305  AC43 HCT 116 C83(0.74); C91(0.74); C324(0.83)  LDD0622  [2]
 LDCM0306  AC44 HCT 116 C324(0.70); C83(0.83); C91(0.83)  LDD0623  [2]
 LDCM0307  AC45 HCT 116 C324(0.73); C83(0.73); C91(0.73)  LDD0624  [2]
 LDCM0308  AC46 HCT 116 C83(1.07); C91(1.07)  LDD0625  [2]
 LDCM0309  AC47 HCT 116 C83(1.01); C91(1.01)  LDD0626  [2]
 LDCM0310  AC48 HCT 116 C83(1.01); C91(1.01)  LDD0627  [2]
 LDCM0311  AC49 HCT 116 C83(1.03); C91(1.03)  LDD0628  [2]
 LDCM0312  AC5 HCT 116 C324(0.82)  LDD0629  [2]
 LDCM0313  AC50 HCT 116 C83(0.97); C91(0.97)  LDD0630  [2]
 LDCM0314  AC51 HCT 116 C83(1.16); C91(1.16)  LDD0631  [2]
 LDCM0315  AC52 HCT 116 C83(0.93); C91(0.93)  LDD0632  [2]
 LDCM0316  AC53 HCT 116 C83(0.93); C91(0.93)  LDD0633  [2]
 LDCM0317  AC54 HCT 116 C83(0.90); C91(0.90)  LDD0634  [2]
 LDCM0318  AC55 HCT 116 C83(0.96); C91(0.96)  LDD0635  [2]
 LDCM0319  AC56 HCT 116 C83(1.28); C91(1.28)  LDD0636  [2]
 LDCM0320  AC57 HCT 116 C324(0.91)  LDD0637  [2]
 LDCM0321  AC58 HCT 116 C324(0.81)  LDD0638  [2]
 LDCM0322  AC59 HCT 116 C324(0.88)  LDD0639  [2]
 LDCM0323  AC6 HCT 116 C83(0.88); C91(0.88)  LDD0640  [2]
 LDCM0324  AC60 HCT 116 C324(0.87)  LDD0641  [2]
 LDCM0325  AC61 HCT 116 C324(0.80)  LDD0642  [2]
 LDCM0326  AC62 HCT 116 C324(0.90)  LDD0643  [2]
 LDCM0327  AC63 HCT 116 C324(0.91)  LDD0644  [2]
 LDCM0328  AC64 HCT 116 C324(0.82)  LDD0645  [2]
 LDCM0329  AC65 HCT 116 C324(0.82)  LDD0646  [2]
 LDCM0330  AC66 HCT 116 C324(0.81)  LDD0647  [2]
 LDCM0331  AC67 HCT 116 C324(0.91)  LDD0648  [2]
 LDCM0332  AC68 HCT 116 C324(0.90); C83(1.35); C91(1.35)  LDD0649  [2]
 LDCM0333  AC69 HCT 116 C324(0.87); C83(1.28); C91(1.28)  LDD0650  [2]
 LDCM0334  AC7 HCT 116 C83(0.83); C91(0.83)  LDD0651  [2]
 LDCM0335  AC70 HCT 116 C83(1.04); C91(1.04); C324(1.42)  LDD0652  [2]
 LDCM0336  AC71 HCT 116 C324(1.01); C83(1.21); C91(1.21)  LDD0653  [2]
 LDCM0337  AC72 HCT 116 C83(0.99); C91(0.99); C324(1.12)  LDD0654  [2]
 LDCM0338  AC73 HCT 116 C324(1.25); C83(1.40); C91(1.40)  LDD0655  [2]
 LDCM0339  AC74 HCT 116 C324(1.14); C83(1.43); C91(1.43)  LDD0656  [2]
 LDCM0340  AC75 HCT 116 C324(1.12); C83(1.74); C91(1.74)  LDD0657  [2]
 LDCM0341  AC76 HCT 116 C324(1.05); C83(1.19); C91(1.19)  LDD0658  [2]
 LDCM0342  AC77 HCT 116 C324(0.86); C83(0.98); C91(0.98)  LDD0659  [2]
 LDCM0343  AC78 HCT 116 C324(1.06); C83(1.11); C91(1.11)  LDD0660  [2]
 LDCM0344  AC79 HCT 116 C324(1.07); C83(1.27); C91(1.27)  LDD0661  [2]
 LDCM0345  AC8 HCT 116 C83(0.90); C91(0.90)  LDD0662  [2]
 LDCM0346  AC80 HCT 116 C324(1.20); C83(1.48); C91(1.48)  LDD0663  [2]
 LDCM0347  AC81 HCT 116 C324(1.16); C83(1.54); C91(1.54)  LDD0664  [2]
 LDCM0348  AC82 HCT 116 C324(1.08); C83(1.54); C91(1.54)  LDD0665  [2]
 LDCM0349  AC83 HEK-293T C91(1.04)  LDD0947  [2]
 LDCM0350  AC84 HEK-293T C91(1.15)  LDD0948  [2]
 LDCM0351  AC85 HEK-293T C91(1.31)  LDD0949  [2]
 LDCM0352  AC86 HEK-293T C91(1.28)  LDD0950  [2]
 LDCM0353  AC87 HEK-293T C91(1.48)  LDD0951  [2]
 LDCM0354  AC88 HEK-293T C91(1.35)  LDD0952  [2]
 LDCM0355  AC89 HEK-293T C91(1.20)  LDD0953  [2]
 LDCM0357  AC90 HEK-293T C91(1.23)  LDD0955  [2]
 LDCM0358  AC91 HEK-293T C91(1.29)  LDD0956  [2]
 LDCM0359  AC92 HEK-293T C91(1.40)  LDD0957  [2]
 LDCM0360  AC93 HEK-293T C91(1.18)  LDD0958  [2]
 LDCM0361  AC94 HEK-293T C91(1.29)  LDD0959  [2]
 LDCM0362  AC95 HEK-293T C91(1.01)  LDD0960  [2]
 LDCM0363  AC96 HEK-293T C91(1.39)  LDD0961  [2]
 LDCM0364  AC97 HEK-293T C91(2.37)  LDD0962  [2]
 LDCM0365  AC98 HEK-293T C91(0.91)  LDD0963  [2]
 LDCM0366  AC99 HEK-293T C91(0.89)  LDD0964  [2]
 LDCM0248  AKOS034007472 HCT 116 C83(0.77); C91(0.77)  LDD0565  [2]
 LDCM0356  AKOS034007680 HCT 116 C83(0.82); C91(0.82)  LDD0673  [2]
 LDCM0275  AKOS034007705 HCT 116 C83(0.85); C91(0.85)  LDD0592  [2]
 LDCM0367  CL1 HCT 116 C324(1.05)  LDD0684  [2]
 LDCM0368  CL10 HCT 116 C324(1.46)  LDD0685  [2]
 LDCM0369  CL100 HCT 116 C324(0.78)  LDD0686  [2]
 LDCM0370  CL101 HCT 116 C83(0.89); C91(0.89)  LDD0687  [2]
 LDCM0371  CL102 HCT 116 C83(1.00); C91(1.00)  LDD0688  [2]
 LDCM0372  CL103 HCT 116 C83(0.98); C91(0.98)  LDD0689  [2]
 LDCM0373  CL104 HCT 116 C83(0.76); C91(0.76)  LDD0690  [2]
 LDCM0374  CL105 HCT 116 C324(1.39)  LDD0691  [2]
 LDCM0375  CL106 HCT 116 C324(1.36)  LDD0692  [2]
 LDCM0376  CL107 HCT 116 C324(1.05)  LDD0693  [2]
 LDCM0377  CL108 HCT 116 C324(1.29)  LDD0694  [2]
 LDCM0378  CL109 HCT 116 C324(1.38)  LDD0695  [2]
 LDCM0379  CL11 HCT 116 C324(1.60)  LDD0696  [2]
 LDCM0380  CL110 HCT 116 C324(1.20)  LDD0697  [2]
 LDCM0381  CL111 HCT 116 C324(1.08)  LDD0698  [2]
 LDCM0382  CL112 HEK-293T C83(0.90); C91(1.28)  LDD0980  [2]
 LDCM0383  CL113 HEK-293T C83(1.19); C91(1.29)  LDD0981  [2]
 LDCM0384  CL114 HEK-293T C83(0.85); C91(1.93)  LDD0982  [2]
 LDCM0385  CL115 HEK-293T C83(0.82); C91(1.54)  LDD0983  [2]
 LDCM0386  CL116 HEK-293T C83(0.91); C91(1.67)  LDD0984  [2]
 LDCM0387  CL117 HCT 116 C324(0.61); C83(1.08); C91(1.08)  LDD0704  [2]
 LDCM0388  CL118 HCT 116 C83(0.69); C91(0.69); C324(0.93)  LDD0705  [2]
 LDCM0389  CL119 HCT 116 C83(0.69); C91(0.69); C324(0.92)  LDD0706  [2]
 LDCM0390  CL12 HCT 116 C324(1.81)  LDD0707  [2]
 LDCM0391  CL120 HCT 116 C83(0.67); C91(0.67); C324(1.00)  LDD0708  [2]
 LDCM0392  CL121 HCT 116 C83(1.59); C91(1.59)  LDD0709  [2]
 LDCM0393  CL122 HCT 116 C83(1.07); C91(1.07)  LDD0710  [2]
 LDCM0394  CL123 HCT 116 C83(1.11); C91(1.11)  LDD0711  [2]
 LDCM0395  CL124 HCT 116 C83(0.99); C91(0.99)  LDD0712  [2]
 LDCM0396  CL125 HCT 116 C324(0.96)  LDD0713  [2]
 LDCM0397  CL126 HCT 116 C324(0.81)  LDD0714  [2]
 LDCM0398  CL127 HCT 116 C324(0.79)  LDD0715  [2]
 LDCM0399  CL128 HCT 116 C324(0.90)  LDD0716  [2]
 LDCM0400  CL13 HCT 116 C324(1.30)  LDD0717  [2]
 LDCM0401  CL14 HCT 116 C324(1.28)  LDD0718  [2]
 LDCM0402  CL15 HCT 116 C324(1.37)  LDD0719  [2]
 LDCM0403  CL16 HEK-293T C91(1.23)  LDD1001  [2]
 LDCM0404  CL17 HEK-293T C91(1.04)  LDD1002  [2]
 LDCM0405  CL18 HEK-293T C91(1.10)  LDD1003  [2]
 LDCM0406  CL19 HEK-293T C91(1.15)  LDD1004  [2]
 LDCM0407  CL2 HCT 116 C324(0.81)  LDD0724  [2]
 LDCM0408  CL20 HEK-293T C91(1.29)  LDD1006  [2]
 LDCM0409  CL21 HEK-293T C91(1.22)  LDD1007  [2]
 LDCM0410  CL22 HEK-293T C91(1.31)  LDD1008  [2]
 LDCM0411  CL23 HEK-293T C91(0.91)  LDD1009  [2]
 LDCM0412  CL24 HEK-293T C91(0.91)  LDD1010  [2]
 LDCM0413  CL25 HEK-293T C91(1.49)  LDD1011  [2]
 LDCM0414  CL26 HEK-293T C91(1.29)  LDD1012  [2]
 LDCM0415  CL27 HEK-293T C91(1.24)  LDD1013  [2]
 LDCM0416  CL28 HEK-293T C91(1.29)  LDD1014  [2]
 LDCM0417  CL29 HEK-293T C91(1.25)  LDD1015  [2]
 LDCM0418  CL3 HCT 116 C324(0.96)  LDD0735  [2]
 LDCM0419  CL30 HEK-293T C91(1.52)  LDD1017  [2]
 LDCM0420  CL31 HEK-293T C83(0.79); C91(1.11)  LDD1018  [2]
 LDCM0421  CL32 HEK-293T C83(0.75); C91(1.29)  LDD1019  [2]
 LDCM0422  CL33 HEK-293T C83(0.79); C91(1.01)  LDD1020  [2]
 LDCM0423  CL34 HEK-293T C83(1.08); C91(0.80)  LDD1021  [2]
 LDCM0424  CL35 HEK-293T C83(0.89); C91(1.17)  LDD1022  [2]
 LDCM0425  CL36 HEK-293T C83(0.95); C91(0.91)  LDD1023  [2]
 LDCM0426  CL37 HEK-293T C83(0.82); C91(0.74)  LDD1024  [2]
 LDCM0428  CL39 HEK-293T C83(0.84); C91(1.24)  LDD1026  [2]
 LDCM0429  CL4 HCT 116 C324(1.10)  LDD0746  [2]
 LDCM0430  CL40 HEK-293T C83(0.84); C91(1.00)  LDD1028  [2]
 LDCM0431  CL41 HEK-293T C83(0.99); C91(1.15)  LDD1029  [2]
 LDCM0432  CL42 HEK-293T C83(0.84); C91(1.24)  LDD1030  [2]
 LDCM0433  CL43 HEK-293T C83(0.92); C91(1.23)  LDD1031  [2]
 LDCM0434  CL44 HEK-293T C83(0.88); C91(0.90)  LDD1032  [2]
 LDCM0435  CL45 HEK-293T C83(0.89); C91(1.30)  LDD1033  [2]
 LDCM0436  CL46 HCT 116 C83(1.36); C91(1.36)  LDD0753  [2]
 LDCM0437  CL47 HCT 116 C83(1.20); C91(1.20)  LDD0754  [2]
 LDCM0438  CL48 HCT 116 C83(1.19); C91(1.19)  LDD0755  [2]
 LDCM0439  CL49 HCT 116 C83(1.17); C91(1.17)  LDD0756  [2]
 LDCM0440  CL5 HCT 116 C324(1.02)  LDD0757  [2]
 LDCM0441  CL50 HCT 116 C83(1.16); C91(1.16)  LDD0758  [2]
 LDCM0442  CL51 HCT 116 C83(1.44); C91(1.44)  LDD0759  [2]
 LDCM0443  CL52 HCT 116 C83(1.24); C91(1.24)  LDD0760  [2]
 LDCM0444  CL53 HCT 116 C83(1.16); C91(1.16)  LDD0761  [2]
 LDCM0445  CL54 HCT 116 C83(1.13); C91(1.13)  LDD0762  [2]
 LDCM0446  CL55 HCT 116 C83(1.38); C91(1.38)  LDD0763  [2]
 LDCM0447  CL56 HCT 116 C83(1.13); C91(1.13)  LDD0764  [2]
 LDCM0448  CL57 HCT 116 C83(1.35); C91(1.35)  LDD0765  [2]
 LDCM0449  CL58 HCT 116 C83(1.19); C91(1.19)  LDD0766  [2]
 LDCM0450  CL59 HCT 116 C83(1.12); C91(1.12)  LDD0767  [2]
 LDCM0451  CL6 HCT 116 C324(1.00)  LDD0768  [2]
 LDCM0452  CL60 HCT 116 C83(1.26); C91(1.26)  LDD0769  [2]
 LDCM0453  CL61 HEK-293T C83(0.73); C91(1.07)  LDD1051  [2]
 LDCM0454  CL62 HEK-293T C83(0.79); C91(1.26)  LDD1052  [2]
 LDCM0455  CL63 HEK-293T C83(0.54); C91(1.19)  LDD1053  [2]
 LDCM0456  CL64 HEK-293T C83(1.18); C91(1.13)  LDD1054  [2]
 LDCM0457  CL65 HEK-293T C83(0.98); C91(1.29)  LDD1055  [2]
 LDCM0458  CL66 HEK-293T C83(0.76); C91(1.44)  LDD1056  [2]
 LDCM0459  CL67 HEK-293T C83(0.83); C91(1.25)  LDD1057  [2]
 LDCM0460  CL68 HEK-293T C83(0.70); C91(1.18)  LDD1058  [2]
 LDCM0461  CL69 HEK-293T C83(0.89); C91(1.11)  LDD1059  [2]
 LDCM0462  CL7 HCT 116 C324(1.65)  LDD0779  [2]
 LDCM0463  CL70 HEK-293T C83(1.41); C91(1.32)  LDD1061  [2]
 LDCM0464  CL71 HEK-293T C83(1.16); C91(1.14)  LDD1062  [2]
 LDCM0465  CL72 HEK-293T C83(1.06); C91(1.29)  LDD1063  [2]
 LDCM0466  CL73 HEK-293T C83(0.87); C91(1.15)  LDD1064  [2]
 LDCM0467  CL74 HEK-293T C83(0.71); C91(2.46)  LDD1065  [2]
 LDCM0469  CL76 HEK-293T C91(1.07)  LDD1067  [2]
 LDCM0470  CL77 HEK-293T C91(1.00)  LDD1068  [2]
 LDCM0471  CL78 HEK-293T C91(0.60)  LDD1069  [2]
 LDCM0472  CL79 HEK-293T C91(1.13)  LDD1070  [2]
 LDCM0473  CL8 HCT 116 C324(0.80)  LDD0790  [2]
 LDCM0474  CL80 HEK-293T C91(0.87)  LDD1072  [2]
 LDCM0475  CL81 HEK-293T C91(0.82)  LDD1073  [2]
 LDCM0476  CL82 HEK-293T C91(0.96)  LDD1074  [2]
 LDCM0477  CL83 HEK-293T C91(1.56)  LDD1075  [2]
 LDCM0478  CL84 HEK-293T C91(0.79)  LDD1076  [2]
 LDCM0479  CL85 HEK-293T C91(0.85)  LDD1077  [2]
 LDCM0480  CL86 HEK-293T C91(0.78)  LDD1078  [2]
 LDCM0481  CL87 HEK-293T C91(1.01)  LDD1079  [2]
 LDCM0482  CL88 HEK-293T C91(1.06)  LDD1080  [2]
 LDCM0483  CL89 HEK-293T C91(0.96)  LDD1081  [2]
 LDCM0484  CL9 HCT 116 C324(1.09)  LDD0801  [2]
 LDCM0485  CL90 HEK-293T C91(1.14)  LDD1083  [2]
 LDCM0486  CL91 HCT 116 C324(0.76)  LDD0803  [2]
 LDCM0487  CL92 HCT 116 C324(0.91)  LDD0804  [2]
 LDCM0488  CL93 HCT 116 C324(0.83)  LDD0805  [2]
 LDCM0489  CL94 HCT 116 C324(0.92)  LDD0806  [2]
 LDCM0490  CL95 HCT 116 C324(0.91)  LDD0807  [2]
 LDCM0491  CL96 HCT 116 C324(0.84)  LDD0808  [2]
 LDCM0492  CL97 HCT 116 C324(0.93)  LDD0809  [2]
 LDCM0493  CL98 HCT 116 C324(0.91)  LDD0810  [2]
 LDCM0494  CL99 HCT 116 C324(0.79)  LDD0811  [2]
 LDCM0495  E2913 HEK-293T C324(0.94); C16(1.23)  LDD1698  [5]
 LDCM0468  Fragment33 HEK-293T C83(0.86); C91(1.61)  LDD1066  [2]
 LDCM0427  Fragment51 HEK-293T C83(0.76); C91(1.01)  LDD1025  [2]
 LDCM0022  KB02 HEK-293T C16(1.14)  LDD1492  [5]
 LDCM0023  KB03 HEK-293T C16(0.77)  LDD1497  [5]
 LDCM0024  KB05 IGR37 C72(2.91)  LDD3314  [6]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Transcription factor
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Signal transducer and activator of transcription 3 (STAT3) Transcription factor STAT family P40763

References

1 Labeling Preferences of Diazirines with Protein Biomolecules. J Am Chem Soc. 2021 May 5;143(17):6691-6700. doi: 10.1021/jacs.1c02509. Epub 2021 Apr 20.
Mass spectrometry data entry: PXD025140
2 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
3 Benchmarking Cleavable Biotin Tags for Peptide-Centric Chemoproteomics. J Proteome Res. 2022 May 6;21(5):1349-1358. doi: 10.1021/acs.jproteome.2c00174. Epub 2022 Apr 25.
Mass spectrometry data entry: PXD031019
4 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
5 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
6 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840