Details of the Target

General Information of Target

Target ID LDTP09151
Target Name Calcium uniporter protein, mitochondrial (MCU)
Gene Name MCU
Gene ID 90550
Synonyms
C10orf42; CCDC109A; Calcium uniporter protein, mitochondrial; HsMCU; Coiled-coil domain-containing protein 109A
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MAAAAGRSLLLLLSSRGGGGGGAGGCGALTAGCFPGLGVSRHRQQQHHRTVHQRIASWQN
LGAVYCSTVVPSDDVTVVYQNGLPVISVRLPSRRERCQFTLKPISDSVGVFLRQLQEEDR
GIDRVAIYSPDGVRVAASTGIDLLLLDDFKLVINDLTYHVRPPKRDLLSHENAATLNDVK
TLVQQLYTTLCIEQHQLNKERELIERLEDLKEQLAPLEKVRIEISRKAEKRTTLVLWGGL
AYMATQFGILARLTWWEYSWDIMEPVTYFITYGSAMAMYAYFVMTRQEYVYPEARDRQYL
LFFHKGAKKSRFDLEKYNQLKDAIAQAEMDLKRLRDPLQVHLPLRQIGEKD
Target Bioclass
Other
Family
MCU (TC 1.A.77) family
Subcellular location
Mitochondrion inner membrane
Function
Mitochondrial inner membrane calcium uniporter that mediates calcium uptake into mitochondria . Constitutes the pore-forming and calcium-conducting subunit of the uniporter complex (uniplex). Activity is regulated by MICU1 and MICU2. At low Ca(2+) levels MCU activity is down-regulated by MICU1 and MICU2; at higher Ca(2+) levels MICU1 increases MCU activity. Mitochondrial calcium homeostasis plays key roles in cellular physiology and regulates cell bioenergetics, cytoplasmic calcium signals and activation of cell death pathways. Involved in buffering the amplitude of systolic calcium rises in cardiomyocytes. While dispensable for baseline homeostatic cardiac function, acts as a key regulator of short-term mitochondrial calcium loading underlying a 'fight-or-flight' response during acute stress: acts by mediating a rapid increase of mitochondrial calcium in pacemaker cells. participates in mitochondrial permeability transition during ischemia-reperfusion injury. Regulates glucose-dependent insulin secretion in pancreatic beta-cells by regulating mitochondrial calcium uptake. Mitochondrial calcium uptake in skeletal muscle cells is involved in muscle size in adults. Regulates synaptic vesicle endocytosis kinetics in central nerve terminal. Involved in antigen processing and presentation.
Uniprot ID
Q8NE86
Ensemble ID
ENST00000357157.10
HGNC ID
HGNC:23526

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
EFO21 SNV: p.E315K DBIA    Probe Info 
HCT15 SNV: p.L12F .
HSC3 SNV: p.E264Ter DBIA    Probe Info 
MCC13 SNV: p.A241V .
WM793 SNV: p.R165K .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 13 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
N1
 Probe Info  		100.00  LDD0242  [1]
DBIA
 Probe Info  		C191(1.68)  LDD3312  [2]
Acrolein
 Probe Info  		N.A.  LDD0221  [3]
4-Iodoacetamidophenylacetylene
 Probe Info  		C97(0.00); C191(0.00)  LDD0038  [4]
IA-alkyne
 Probe Info  		C97(0.00); C191(0.00)  LDD0036  [4]
IPIAA_H
 Probe Info  		N.A.  LDD0030  [5]
IPIAA_L
 Probe Info  		N.A.  LDD0031  [5]
Lodoacetamide azide
 Probe Info  		C191(0.00); C97(0.00)  LDD0037  [4]
IPM
 Probe Info  		N.A.  LDD0005  [6]
TFBX
 Probe Info  		N.A.  LDD0148  [7]
W1
 Probe Info  		N.A.  LDD0236  [8]
NAIA_5
 Probe Info  		C97(0.00); C191(0.00)  LDD2223  [9]
TER-AC
 Probe Info  		N.A.  LDD0426  [10]
PAL-AfBPP Probe
Click To Hide/Show 3 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C350
 Probe Info  		27.28  LDD2011  [11]
STS-2
 Probe Info  		N.A.  LDD0138  [12]
VE-P
 Probe Info  		N.A.  LDD0396  [13]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HEK-293T C191(0.99); C97(1.20)  LDD1507  [14]
 LDCM0215  AC10 HEK-293T C191(0.99); C97(1.33)  LDD1508  [14]
 LDCM0226  AC11 HEK-293T C97(1.14)  LDD1509  [14]
 LDCM0237  AC12 HEK-293T C191(0.89); C97(1.30)  LDD1510  [14]
 LDCM0246  AC128 PaTu 8988t C191(0.81)  LDD1125  [15]
 LDCM0247  AC129 PaTu 8988t C191(0.81)  LDD1126  [15]
 LDCM0249  AC130 PaTu 8988t C191(0.82)  LDD1128  [15]
 LDCM0250  AC131 PaTu 8988t C191(0.97)  LDD1129  [15]
 LDCM0251  AC132 PaTu 8988t C191(1.03)  LDD1130  [15]
 LDCM0252  AC133 PaTu 8988t C191(0.97)  LDD1131  [15]
 LDCM0253  AC134 PaTu 8988t C191(0.89)  LDD1132  [15]
 LDCM0254  AC135 PaTu 8988t C191(0.84)  LDD1133  [15]
 LDCM0255  AC136 PaTu 8988t C191(0.72)  LDD1134  [15]
 LDCM0256  AC137 PaTu 8988t C191(0.74)  LDD1135  [15]
 LDCM0257  AC138 PaTu 8988t C191(0.90)  LDD1136  [15]
 LDCM0258  AC139 PaTu 8988t C191(0.74)  LDD1137  [15]
 LDCM0259  AC14 HEK-293T C97(1.81)  LDD1512  [14]
 LDCM0260  AC140 PaTu 8988t C191(0.91)  LDD1139  [15]
 LDCM0261  AC141 PaTu 8988t C191(0.95)  LDD1140  [15]
 LDCM0262  AC142 PaTu 8988t C191(0.98)  LDD1141  [15]
 LDCM0270  AC15 HEK-293T C191(0.88); C97(1.24)  LDD1513  [14]
 LDCM0276  AC17 HEK-293T C191(0.93); C97(1.27)  LDD1515  [14]
 LDCM0277  AC18 HEK-293T C191(1.02); C97(1.07)  LDD1516  [14]
 LDCM0278  AC19 HEK-293T C97(1.26)  LDD1517  [14]
 LDCM0279  AC2 HEK-293T C191(1.05); C97(1.25)  LDD1518  [14]
 LDCM0280  AC20 HEK-293T C191(0.86); C97(1.40)  LDD1519  [14]
 LDCM0281  AC21 HEK-293T C191(0.94); C97(1.00)  LDD1520  [14]
 LDCM0282  AC22 HEK-293T C97(1.46)  LDD1521  [14]
 LDCM0283  AC23 HEK-293T C191(0.94); C97(1.31)  LDD1522  [14]
 LDCM0284  AC24 HEK-293T C191(1.03); C97(1.22)  LDD1523  [14]
 LDCM0285  AC25 PaTu 8988t C191(0.94)  LDD1164  [15]
 LDCM0286  AC26 PaTu 8988t C191(1.18)  LDD1165  [15]
 LDCM0287  AC27 PaTu 8988t C191(1.34)  LDD1166  [15]
 LDCM0288  AC28 PaTu 8988t C191(1.28)  LDD1167  [15]
 LDCM0289  AC29 PaTu 8988t C191(1.18)  LDD1168  [15]
 LDCM0290  AC3 HEK-293T C97(1.16)  LDD1529  [14]
 LDCM0291  AC30 PaTu 8988t C191(1.22)  LDD1170  [15]
 LDCM0292  AC31 PaTu 8988t C191(1.09)  LDD1171  [15]
 LDCM0293  AC32 PaTu 8988t C191(1.22)  LDD1172  [15]
 LDCM0294  AC33 PaTu 8988t C191(1.13)  LDD1173  [15]
 LDCM0295  AC34 PaTu 8988t C191(1.04)  LDD1174  [15]
 LDCM0296  AC35 PaTu 8988t C191(1.31)  LDD1175  [15]
 LDCM0297  AC36 PaTu 8988t C191(0.99)  LDD1176  [15]
 LDCM0298  AC37 PaTu 8988t C191(1.39)  LDD1177  [15]
 LDCM0299  AC38 PaTu 8988t C191(0.98)  LDD1178  [15]
 LDCM0300  AC39 PaTu 8988t C191(1.19)  LDD1179  [15]
 LDCM0301  AC4 HEK-293T C191(0.95); C97(1.23)  LDD1540  [14]
 LDCM0302  AC40 PaTu 8988t C191(1.51)  LDD1181  [15]
 LDCM0303  AC41 PaTu 8988t C191(0.94)  LDD1182  [15]
 LDCM0304  AC42 PaTu 8988t C191(1.13)  LDD1183  [15]
 LDCM0305  AC43 PaTu 8988t C191(1.00)  LDD1184  [15]
 LDCM0306  AC44 PaTu 8988t C191(1.11)  LDD1185  [15]
 LDCM0307  AC45 PaTu 8988t C191(1.39)  LDD1186  [15]
 LDCM0308  AC46 PaTu 8988t C191(1.04)  LDD1187  [15]
 LDCM0309  AC47 PaTu 8988t C191(1.01)  LDD1188  [15]
 LDCM0310  AC48 PaTu 8988t C191(0.91)  LDD1189  [15]
 LDCM0311  AC49 PaTu 8988t C191(1.00)  LDD1190  [15]
 LDCM0312  AC5 HEK-293T C191(1.04); C97(1.06)  LDD1551  [14]
 LDCM0313  AC50 PaTu 8988t C191(1.10)  LDD1192  [15]
 LDCM0314  AC51 PaTu 8988t C191(1.00)  LDD1193  [15]
 LDCM0315  AC52 PaTu 8988t C191(1.03)  LDD1194  [15]
 LDCM0316  AC53 PaTu 8988t C191(0.92)  LDD1195  [15]
 LDCM0317  AC54 PaTu 8988t C191(1.03)  LDD1196  [15]
 LDCM0318  AC55 PaTu 8988t C191(0.97)  LDD1197  [15]
 LDCM0319  AC56 PaTu 8988t C191(1.49)  LDD1198  [15]
 LDCM0320  AC57 HEK-293T C191(0.87); C97(1.19)  LDD1559  [14]
 LDCM0321  AC58 HEK-293T C191(0.92); C97(1.10)  LDD1560  [14]
 LDCM0322  AC59 HEK-293T C97(1.15)  LDD1561  [14]
 LDCM0323  AC6 HEK-293T C97(1.20)  LDD1562  [14]
 LDCM0324  AC60 HEK-293T C191(0.93); C97(1.32)  LDD1563  [14]
 LDCM0325  AC61 HEK-293T C191(0.96); C97(1.06)  LDD1564  [14]
 LDCM0326  AC62 HEK-293T C97(1.29)  LDD1565  [14]
 LDCM0327  AC63 HEK-293T C191(0.93); C97(1.23)  LDD1566  [14]
 LDCM0328  AC64 HEK-293T C191(1.09); C97(1.11)  LDD1567  [14]
 LDCM0334  AC7 HEK-293T C191(1.03); C97(1.24)  LDD1568  [14]
 LDCM0345  AC8 HEK-293T C191(1.15); C97(1.07)  LDD1569  [14]
 LDCM0248  AKOS034007472 HEK-293T C191(0.92); C97(0.90)  LDD1511  [14]
 LDCM0356  AKOS034007680 HEK-293T C191(0.93); C97(1.28)  LDD1570  [14]
 LDCM0275  AKOS034007705 HEK-293T C191(1.14); C97(1.18)  LDD1514  [14]
 LDCM0367  CL1 HEK-293T C191(0.91)  LDD1571  [14]
 LDCM0368  CL10 HEK-293T C97(0.54)  LDD1572  [14]
 LDCM0369  CL100 HEK-293T C191(0.95); C97(1.35)  LDD1573  [14]
 LDCM0370  CL101 HEK-293T C191(0.91)  LDD1574  [14]
 LDCM0371  CL102 HEK-293T C191(0.90); C97(1.21)  LDD1575  [14]
 LDCM0372  CL103 HEK-293T C191(1.07); C97(1.46)  LDD1576  [14]
 LDCM0373  CL104 HEK-293T C191(1.03); C97(1.56)  LDD1577  [14]
 LDCM0374  CL105 HEK-293T C191(0.95)  LDD1578  [14]
 LDCM0375  CL106 HEK-293T C191(0.94); C97(1.12)  LDD1579  [14]
 LDCM0376  CL107 HEK-293T C191(1.02); C97(1.38)  LDD1580  [14]
 LDCM0377  CL108 HEK-293T C191(0.99); C97(1.20)  LDD1581  [14]
 LDCM0378  CL109 HEK-293T C191(0.94)  LDD1582  [14]
 LDCM0379  CL11 HEK-293T C191(1.04); C97(0.59)  LDD1583  [14]
 LDCM0380  CL110 HEK-293T C191(0.79); C97(1.17)  LDD1584  [14]
 LDCM0381  CL111 HEK-293T C191(0.94); C97(1.17)  LDD1585  [14]
 LDCM0382  CL112 PaTu 8988t C191(0.97)  LDD1261  [15]
 LDCM0383  CL113 PaTu 8988t C191(1.08)  LDD1262  [15]
 LDCM0384  CL114 PaTu 8988t C191(1.09)  LDD1263  [15]
 LDCM0385  CL115 PaTu 8988t C191(1.18)  LDD1264  [15]
 LDCM0386  CL116 PaTu 8988t C191(1.13)  LDD1265  [15]
 LDCM0387  CL117 PaTu 8988t C191(0.90)  LDD1266  [15]
 LDCM0388  CL118 PaTu 8988t C191(0.75)  LDD1267  [15]
 LDCM0389  CL119 PaTu 8988t C191(0.97)  LDD1268  [15]
 LDCM0390  CL12 HEK-293T C191(1.11); C97(0.63)  LDD1594  [14]
 LDCM0391  CL120 PaTu 8988t C191(0.98)  LDD1270  [15]
 LDCM0392  CL121 PaTu 8988t C191(0.91)  LDD1271  [15]
 LDCM0393  CL122 PaTu 8988t C191(1.94)  LDD1272  [15]
 LDCM0394  CL123 PaTu 8988t C191(0.95)  LDD1273  [15]
 LDCM0395  CL124 PaTu 8988t C191(0.95)  LDD1274  [15]
 LDCM0396  CL125 HEK-293T C191(1.01)  LDD1600  [14]
 LDCM0397  CL126 HEK-293T C191(0.94); C97(1.01)  LDD1601  [14]
 LDCM0398  CL127 HEK-293T C191(1.04); C97(1.27)  LDD1602  [14]
 LDCM0399  CL128 HEK-293T C191(1.04); C97(1.25)  LDD1603  [14]
 LDCM0400  CL13 HEK-293T C191(0.88)  LDD1604  [14]
 LDCM0401  CL14 HEK-293T C191(0.95); C97(1.18)  LDD1605  [14]
 LDCM0402  CL15 HEK-293T C191(0.97); C97(1.10)  LDD1606  [14]
 LDCM0403  CL16 HEK-293T C191(0.97); C97(1.20)  LDD1607  [14]
 LDCM0404  CL17 HEK-293T C191(0.76); C97(0.89)  LDD1608  [14]
 LDCM0405  CL18 HEK-293T C191(0.92); C97(0.83)  LDD1609  [14]
 LDCM0406  CL19 HEK-293T C97(0.83)  LDD1610  [14]
 LDCM0407  CL2 HEK-293T C191(1.02); C97(1.04)  LDD1611  [14]
 LDCM0408  CL20 HEK-293T C191(0.85); C97(0.69)  LDD1612  [14]
 LDCM0409  CL21 HEK-293T C191(0.81); C97(0.58)  LDD1613  [14]
 LDCM0410  CL22 HEK-293T C97(0.59)  LDD1614  [14]
 LDCM0411  CL23 HEK-293T C191(0.91); C97(0.60)  LDD1615  [14]
 LDCM0412  CL24 HEK-293T C191(1.29); C97(0.55)  LDD1616  [14]
 LDCM0413  CL25 HEK-293T C191(0.92)  LDD1617  [14]
 LDCM0414  CL26 HEK-293T C191(0.99); C97(1.25)  LDD1618  [14]
 LDCM0415  CL27 HEK-293T C191(1.14); C97(1.11)  LDD1619  [14]
 LDCM0416  CL28 HEK-293T C191(0.93); C97(1.08)  LDD1620  [14]
 LDCM0417  CL29 HEK-293T C191(0.93); C97(1.12)  LDD1621  [14]
 LDCM0418  CL3 HEK-293T C191(0.90); C97(1.15)  LDD1622  [14]
 LDCM0419  CL30 HEK-293T C191(0.92); C97(0.76)  LDD1623  [14]
 LDCM0420  CL31 HEK-293T C97(0.75)  LDD1624  [14]
 LDCM0421  CL32 HEK-293T C191(0.83); C97(0.67)  LDD1625  [14]
 LDCM0422  CL33 HEK-293T C191(0.76); C97(0.60)  LDD1626  [14]
 LDCM0423  CL34 HEK-293T C97(0.62)  LDD1627  [14]
 LDCM0424  CL35 HEK-293T C191(0.91); C97(0.56)  LDD1628  [14]
 LDCM0425  CL36 HEK-293T C191(1.13); C97(0.53)  LDD1629  [14]
 LDCM0426  CL37 HEK-293T C191(0.99)  LDD1630  [14]
 LDCM0428  CL39 HEK-293T C191(1.03); C97(1.03)  LDD1632  [14]
 LDCM0429  CL4 HEK-293T C191(0.89); C97(1.21)  LDD1633  [14]
 LDCM0430  CL40 HEK-293T C191(0.89); C97(1.09)  LDD1634  [14]
 LDCM0431  CL41 HEK-293T C191(0.83); C97(0.84)  LDD1635  [14]
 LDCM0432  CL42 HEK-293T C191(0.96); C97(0.66)  LDD1636  [14]
 LDCM0433  CL43 HEK-293T C97(0.80)  LDD1637  [14]
 LDCM0434  CL44 HEK-293T C191(0.98); C97(0.71)  LDD1638  [14]
 LDCM0435  CL45 HEK-293T C191(0.88); C97(0.59)  LDD1639  [14]
 LDCM0436  CL46 PaTu 8988t C191(1.10)  LDD1315  [15]
 LDCM0437  CL47 PaTu 8988t C191(1.05)  LDD1316  [15]
 LDCM0438  CL48 PaTu 8988t C191(1.08)  LDD1317  [15]
 LDCM0439  CL49 PaTu 8988t C191(1.10)  LDD1318  [15]
 LDCM0440  CL5 HEK-293T C191(0.94); C97(0.89)  LDD1644  [14]
 LDCM0441  CL50 PaTu 8988t C191(1.22)  LDD1320  [15]
 LDCM0442  CL51 PaTu 8988t C191(0.96)  LDD1321  [15]
 LDCM0443  CL52 PaTu 8988t C191(1.10)  LDD1322  [15]
 LDCM0444  CL53 PaTu 8988t C191(1.19)  LDD1323  [15]
 LDCM0445  CL54 PaTu 8988t C191(1.00)  LDD1324  [15]
 LDCM0446  CL55 PaTu 8988t C191(1.03)  LDD1325  [15]
 LDCM0447  CL56 PaTu 8988t C191(1.13)  LDD1326  [15]
 LDCM0448  CL57 PaTu 8988t C191(1.17)  LDD1327  [15]
 LDCM0449  CL58 PaTu 8988t C191(1.17)  LDD1328  [15]
 LDCM0450  CL59 PaTu 8988t C191(1.13)  LDD1329  [15]
 LDCM0451  CL6 HEK-293T C191(0.89); C97(0.77)  LDD1654  [14]
 LDCM0452  CL60 PaTu 8988t C191(1.13)  LDD1331  [15]
 LDCM0453  CL61 PaTu 8988t C191(0.92)  LDD1332  [15]
 LDCM0454  CL62 PaTu 8988t C191(0.76)  LDD1333  [15]
 LDCM0455  CL63 PaTu 8988t C191(0.86)  LDD1334  [15]
 LDCM0456  CL64 PaTu 8988t C191(0.86)  LDD1335  [15]
 LDCM0457  CL65 PaTu 8988t C191(0.99)  LDD1336  [15]
 LDCM0458  CL66 PaTu 8988t C191(1.01)  LDD1337  [15]
 LDCM0459  CL67 PaTu 8988t C191(1.05)  LDD1338  [15]
 LDCM0460  CL68 PaTu 8988t C191(1.18)  LDD1339  [15]
 LDCM0461  CL69 PaTu 8988t C191(1.09)  LDD1340  [15]
 LDCM0462  CL7 HEK-293T C97(0.81)  LDD1665  [14]
 LDCM0463  CL70 PaTu 8988t C191(1.04)  LDD1342  [15]
 LDCM0464  CL71 PaTu 8988t C191(0.78)  LDD1343  [15]
 LDCM0465  CL72 PaTu 8988t C191(0.77)  LDD1344  [15]
 LDCM0466  CL73 PaTu 8988t C191(1.07)  LDD1345  [15]
 LDCM0467  CL74 PaTu 8988t C191(0.85)  LDD1346  [15]
 LDCM0469  CL76 HEK-293T C191(0.97); C97(1.31)  LDD1672  [14]
 LDCM0470  CL77 HEK-293T C191(0.83); C97(0.87)  LDD1673  [14]
 LDCM0471  CL78 HEK-293T C191(0.94); C97(0.94)  LDD1674  [14]
 LDCM0472  CL79 HEK-293T C97(0.81)  LDD1675  [14]
 LDCM0473  CL8 HEK-293T C191(0.71); C97(0.64)  LDD1676  [14]
 LDCM0474  CL80 HEK-293T C191(0.89); C97(0.74)  LDD1677  [14]
 LDCM0475  CL81 HEK-293T C191(0.92); C97(0.64)  LDD1678  [14]
 LDCM0476  CL82 HEK-293T C97(0.82)  LDD1679  [14]
 LDCM0477  CL83 HEK-293T C191(0.88); C97(0.71)  LDD1680  [14]
 LDCM0478  CL84 HEK-293T C191(1.02); C97(0.65)  LDD1681  [14]
 LDCM0479  CL85 HEK-293T C191(0.99)  LDD1682  [14]
 LDCM0480  CL86 HEK-293T C191(0.98); C97(1.11)  LDD1683  [14]
 LDCM0481  CL87 HEK-293T C191(1.21); C97(1.32)  LDD1684  [14]
 LDCM0482  CL88 HEK-293T C191(0.92); C97(1.40)  LDD1685  [14]
 LDCM0483  CL89 HEK-293T C191(0.85); C97(1.17)  LDD1686  [14]
 LDCM0484  CL9 HEK-293T C191(0.96); C97(0.56)  LDD1687  [14]
 LDCM0485  CL90 HEK-293T C191(0.79); C97(0.93)  LDD1688  [14]
 LDCM0486  CL91 HEK-293T C97(0.91)  LDD1689  [14]
 LDCM0487  CL92 HEK-293T C191(0.85); C97(0.80)  LDD1690  [14]
 LDCM0488  CL93 HEK-293T C191(0.80); C97(0.67)  LDD1691  [14]
 LDCM0489  CL94 HEK-293T C97(0.79)  LDD1692  [14]
 LDCM0490  CL95 HEK-293T C191(0.69); C97(0.85)  LDD1693  [14]
 LDCM0491  CL96 HEK-293T C191(1.12); C97(0.74)  LDD1694  [14]
 LDCM0492  CL97 HEK-293T C191(0.96)  LDD1695  [14]
 LDCM0493  CL98 HEK-293T C191(1.02); C97(1.27)  LDD1696  [14]
 LDCM0494  CL99 HEK-293T C191(1.08); C97(1.10)  LDD1697  [14]
 LDCM0495  E2913 HEK-293T C191(0.98); C97(1.09)  LDD1698  [14]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C97(5.89)  LDD1702  [16]
 LDCM0625  F8 Ramos C97(0.59)  LDD2187  [17]
 LDCM0576  Fragment14 Ramos C97(1.34)  LDD2193  [17]
 LDCM0468  Fragment33 PaTu 8988t C191(1.28)  LDD1347  [15]
 LDCM0427  Fragment51 HEK-293T C191(0.98); C97(1.10)  LDD1631  [14]
 LDCM0569  Fragment7 Ramos C97(1.28)  LDD2186  [17]
 LDCM0107  IAA HeLa N.A.  LDD0221  [3]
 LDCM0022  KB02 HEK-293T C191(0.98)  LDD1492  [14]
 LDCM0023  KB03 HEK-293T C191(0.98)  LDD1497  [14]
 LDCM0024  KB05 HMCB C191(1.68)  LDD3312  [2]
 LDCM0109  NEM HeLa N.A.  LDD0223  [3]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Transporter and channel
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Calcium uptake protein 1, mitochondrial (MICU1) MICU1 family Q9BPX6
Essential MCU regulator, mitochondrial (SMDT1) SMDT1/EMRE family Q9H4I9
Other
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Mitochondrial calcium uniporter regulator 1 (MCUR1) CCDC90 family Q96AQ8

References

1 Cyclopropenone, Cyclopropeniminium Ion, and Cyclopropenethione as Novel Electrophilic Warheads for Potential Target Discovery of Triple-Negative Breast Cancer. J Med Chem. 2023 Feb 23;66(4):2851-2864. doi: 10.1021/acs.jmedchem.2c01889. Epub 2023 Feb 10.
2 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
3 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
4 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
5 SP3-Enabled Rapid and High Coverage Chemoproteomic Identification of Cell-State-Dependent Redox-Sensitive Cysteines. Mol Cell Proteomics. 2022 Apr;21(4):100218. doi: 10.1016/j.mcpro.2022.100218. Epub 2022 Feb 25.
Mass spectrometry data entry: PXD029500 , PXD031647
6 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
7 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
8 Oxidant-Induced Bioconjugation for Protein Labeling in Live Cells. ACS Chem Biol. 2023 Jan 20;18(1):112-122. doi: 10.1021/acschembio.2c00740. Epub 2022 Dec 21.
9 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
10 Differently Tagged Probes for Protein Profiling of Mitochondria. Chembiochem. 2019 May 2;20(9):1155-1160. doi: 10.1002/cbic.201800735. Epub 2019 Mar 26.
11 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587
12 Design and synthesis of minimalist terminal alkyne-containing diazirine photo-crosslinkers and their incorporation into kinase inhibitors for cell- and tissue-based proteome profiling. Angew Chem Int Ed Engl. 2013 Aug 12;52(33):8551-6. doi: 10.1002/anie.201300683. Epub 2013 Jun 10.
13 Pharmacological Targeting of Vacuolar H(+)-ATPase via Subunit V1G Combats Multidrug-Resistant Cancer. Cell Chem Biol. 2020 Nov 19;27(11):1359-1370.e8. doi: 10.1016/j.chembiol.2020.06.011. Epub 2020 Jul 9.
14 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
15 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
16 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
17 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578