Details of the Target

General Information of Target

Target ID LDTP08957
Target Name Tumor suppressor ARF (CDKN2A)
Gene Name CDKN2A
Gene ID 1029
Synonyms
CDKN2; MLM; Tumor suppressor ARF; Alternative reading frame; ARF; Cyclin-dependent kinase inhibitor 2A; p14ARF
3D Structure
Download
2D Sequence (FASTA)
Download
3D Structure (PDB)
Download
Sequence
MVRRFLVTLRIRRACGPPRVRVFVVHIPRLTGEWAAPGAPAAVALVLMLLRSQRLGQQPL
PRRPGHDDGQRPSGGAAAAPRRGAQLRRPRHSHPTRARRCPGGLPGHAGGAAPGRGAAGR
ARCLGPSARGPG
Target Bioclass
Other
Subcellular location
Nucleus, nucleolus; Mitochondrion
Function
Capable of inducing cell cycle arrest in G1 and G2 phases. Acts as a tumor suppressor. Binds to MDM2 and blocks its nucleocytoplasmic shuttling by sequestering it in the nucleolus. This inhibits the oncogenic action of MDM2 by blocking MDM2-induced degradation of p53 and enhancing p53-dependent transactivation and apoptosis. Also induces G2 arrest and apoptosis in a p53-independent manner by preventing the activation of cyclin B1/CDC2 complexes. Binds to BCL6 and down-regulates BCL6-induced transcriptional repression. Binds to E2F1 and MYC and blocks their transcriptional activator activity but has no effect on MYC transcriptional repression. Binds to TOP1/TOPOI and stimulates its activity. This complex binds to rRNA gene promoters and may play a role in rRNA transcription and/or maturation. Interacts with NPM1/B23 and promotes its polyubiquitination and degradation, thus inhibiting rRNA processing. Plays a role in inhibiting ribosome biogenesis, perhaps by binding to the nucleolar localization sequence of transcription termination factor TTF1, and thereby preventing nucleolar localization of TTF1. Interacts with COMMD1 and promotes its 'Lys63'-linked polyubiquitination. Interacts with UBE2I/UBC9 and enhances sumoylation of a number of its binding partners including MDM2 and E2F1. Binds to HUWE1 and represses its ubiquitin ligase activity. May play a role in controlling cell proliferation and apoptosis during mammary gland development.; [Isoform smARF]: May be involved in regulation of autophagy and caspase-independent cell death; the short-lived mitochondrial isoform is stabilized by C1QBP.
Uniprot ID
Q8N726
Ensemble ID
ENST00000530628.2
HGNC ID
HGNC:1787

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
HCT116 Deletion: p.E33SfsTer15 .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 13 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		15.00  LDD0402  [1]
AHL-Pu-1
 Probe Info  		C100(2.03)  LDD0169  [2]
DBIA
 Probe Info  		C100(0.95)  LDD0078  [3]
IA-alkyne
 Probe Info  		N.A.  LDD0165  [4]
JW-RF-010
 Probe Info  		N.A.  LDD0026  [5]
TFBX
 Probe Info  		C100(0.00); C123(0.00)  LDD0027  [5]
IPM
 Probe Info  		C123(0.00); C100(0.00)  LDD0005  [6]
NPM
 Probe Info  		N.A.  LDD0016  [6]
Phosphinate-6
 Probe Info  		C100(0.00); C123(0.00)  LDD0018  [7]
Acrolein
 Probe Info  		H66(0.00); C100(0.00)  LDD0217  [8]
Crotonaldehyde
 Probe Info  		N.A.  LDD0219  [8]
Methacrolein
 Probe Info  		N.A.  LDD0218  [8]
AOyne
 Probe Info  		15.00  LDD0443  [9]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0026  4SU-RNA+native RNA HEK-293T C100(2.03)  LDD0169  [2]
 LDCM0214  AC1 HEK-293T C100(0.91); C123(0.99)  LDD1507  [10]
 LDCM0215  AC10 PaTu 8988t C100(1.15)  LDD1094  [3]
 LDCM0226  AC11 PaTu 8988t C100(1.36)  LDD1105  [3]
 LDCM0237  AC12 PaTu 8988t C100(1.16)  LDD1116  [3]
 LDCM0246  AC128 PaTu 8988t C100(1.13)  LDD1125  [3]
 LDCM0247  AC129 PaTu 8988t C100(1.01)  LDD1126  [3]
 LDCM0249  AC130 PaTu 8988t C100(1.10)  LDD1128  [3]
 LDCM0250  AC131 PaTu 8988t C100(1.10)  LDD1129  [3]
 LDCM0251  AC132 PaTu 8988t C100(1.28)  LDD1130  [3]
 LDCM0252  AC133 PaTu 8988t C100(1.30)  LDD1131  [3]
 LDCM0253  AC134 PaTu 8988t C100(0.99)  LDD1132  [3]
 LDCM0254  AC135 PaTu 8988t C100(1.60)  LDD1133  [3]
 LDCM0255  AC136 PaTu 8988t C100(1.19)  LDD1134  [3]
 LDCM0256  AC137 PaTu 8988t C100(1.31)  LDD1135  [3]
 LDCM0257  AC138 PaTu 8988t C100(0.97)  LDD1136  [3]
 LDCM0258  AC139 PaTu 8988t C100(0.88)  LDD1137  [3]
 LDCM0259  AC14 PaTu 8988t C100(0.94)  LDD1138  [3]
 LDCM0260  AC140 PaTu 8988t C100(1.09)  LDD1139  [3]
 LDCM0261  AC141 PaTu 8988t C100(1.04)  LDD1140  [3]
 LDCM0262  AC142 PaTu 8988t C100(0.91)  LDD1141  [3]
 LDCM0270  AC15 PaTu 8988t C100(1.07)  LDD1149  [3]
 LDCM0276  AC17 PaTu 8988t C100(0.90)  LDD1155  [3]
 LDCM0277  AC18 PaTu 8988t C100(1.10)  LDD1156  [3]
 LDCM0278  AC19 PaTu 8988t C100(0.89)  LDD1157  [3]
 LDCM0279  AC2 HEK-293T C100(0.89); C123(0.92)  LDD1518  [10]
 LDCM0280  AC20 PaTu 8988t C100(1.43)  LDD1159  [3]
 LDCM0281  AC21 PaTu 8988t C100(1.18)  LDD1160  [3]
 LDCM0282  AC22 PaTu 8988t C100(1.45)  LDD1161  [3]
 LDCM0283  AC23 PaTu 8988t C100(1.69)  LDD1162  [3]
 LDCM0284  AC24 PaTu 8988t C100(1.30)  LDD1163  [3]
 LDCM0285  AC25 PaTu 8988t C100(1.60)  LDD1164  [3]
 LDCM0286  AC26 PaTu 8988t C100(1.39)  LDD1165  [3]
 LDCM0287  AC27 PaTu 8988t C100(1.70)  LDD1166  [3]
 LDCM0288  AC28 PaTu 8988t C100(1.94)  LDD1167  [3]
 LDCM0289  AC29 PaTu 8988t C100(1.44)  LDD1168  [3]
 LDCM0290  AC3 HEK-293T C100(0.92); C123(0.98)  LDD1529  [10]
 LDCM0291  AC30 PaTu 8988t C100(1.50)  LDD1170  [3]
 LDCM0292  AC31 PaTu 8988t C100(1.57)  LDD1171  [3]
 LDCM0293  AC32 PaTu 8988t C100(1.38)  LDD1172  [3]
 LDCM0294  AC33 PaTu 8988t C100(1.71)  LDD1173  [3]
 LDCM0295  AC34 PaTu 8988t C100(1.22)  LDD1174  [3]
 LDCM0296  AC35 PaTu 8988t C100(1.40)  LDD1175  [3]
 LDCM0297  AC36 PaTu 8988t C100(1.67)  LDD1176  [3]
 LDCM0298  AC37 PaTu 8988t C100(1.42)  LDD1177  [3]
 LDCM0299  AC38 PaTu 8988t C100(1.27)  LDD1178  [3]
 LDCM0300  AC39 PaTu 8988t C100(1.50)  LDD1179  [3]
 LDCM0301  AC4 HEK-293T C100(1.01); C123(0.98)  LDD1540  [10]
 LDCM0302  AC40 PaTu 8988t C100(1.54)  LDD1181  [3]
 LDCM0303  AC41 PaTu 8988t C100(1.24)  LDD1182  [3]
 LDCM0304  AC42 PaTu 8988t C100(1.16)  LDD1183  [3]
 LDCM0305  AC43 PaTu 8988t C100(1.27)  LDD1184  [3]
 LDCM0306  AC44 PaTu 8988t C100(1.48)  LDD1185  [3]
 LDCM0307  AC45 PaTu 8988t C100(1.15)  LDD1186  [3]
 LDCM0308  AC46 PaTu 8988t C100(1.14)  LDD1187  [3]
 LDCM0309  AC47 PaTu 8988t C100(1.30)  LDD1188  [3]
 LDCM0310  AC48 PaTu 8988t C100(1.37)  LDD1189  [3]
 LDCM0311  AC49 PaTu 8988t C100(1.59)  LDD1190  [3]
 LDCM0312  AC5 HEK-293T C100(1.00); C123(0.99)  LDD1551  [10]
 LDCM0313  AC50 PaTu 8988t C100(1.68)  LDD1192  [3]
 LDCM0314  AC51 PaTu 8988t C100(0.78)  LDD1193  [3]
 LDCM0315  AC52 PaTu 8988t C100(1.27)  LDD1194  [3]
 LDCM0316  AC53 PaTu 8988t C100(1.90)  LDD1195  [3]
 LDCM0317  AC54 PaTu 8988t C100(2.01)  LDD1196  [3]
 LDCM0318  AC55 PaTu 8988t C100(1.20)  LDD1197  [3]
 LDCM0319  AC56 PaTu 8988t C100(1.68)  LDD1198  [3]
 LDCM0320  AC57 PaTu 8988t C100(1.36)  LDD1199  [3]
 LDCM0321  AC58 PaTu 8988t C100(1.32)  LDD1200  [3]
 LDCM0322  AC59 PaTu 8988t C100(1.38)  LDD1201  [3]
 LDCM0323  AC6 PaTu 8988t C100(1.13)  LDD1202  [3]
 LDCM0324  AC60 PaTu 8988t C100(1.32)  LDD1203  [3]
 LDCM0325  AC61 PaTu 8988t C100(0.87)  LDD1204  [3]
 LDCM0326  AC62 PaTu 8988t C100(0.98)  LDD1205  [3]
 LDCM0327  AC63 PaTu 8988t C100(0.84)  LDD1206  [3]
 LDCM0328  AC64 PaTu 8988t C100(0.89)  LDD1207  [3]
 LDCM0329  AC65 PaTu 8988t C100(0.72)  LDD1208  [3]
 LDCM0330  AC66 PaTu 8988t C100(0.83)  LDD1209  [3]
 LDCM0331  AC67 PaTu 8988t C100(1.00)  LDD1210  [3]
 LDCM0332  AC68 PaTu 8988t C100(0.98)  LDD1211  [3]
 LDCM0333  AC69 PaTu 8988t C100(1.02)  LDD1212  [3]
 LDCM0334  AC7 PaTu 8988t C100(0.97)  LDD1213  [3]
 LDCM0335  AC70 PaTu 8988t C100(1.14)  LDD1214  [3]
 LDCM0336  AC71 PaTu 8988t C100(1.24)  LDD1215  [3]
 LDCM0337  AC72 PaTu 8988t C100(1.06)  LDD1216  [3]
 LDCM0338  AC73 PaTu 8988t C100(0.98)  LDD1217  [3]
 LDCM0339  AC74 PaTu 8988t C100(1.30)  LDD1218  [3]
 LDCM0340  AC75 PaTu 8988t C100(1.49)  LDD1219  [3]
 LDCM0341  AC76 PaTu 8988t C100(1.10)  LDD1220  [3]
 LDCM0342  AC77 PaTu 8988t C100(1.20)  LDD1221  [3]
 LDCM0343  AC78 PaTu 8988t C100(1.25)  LDD1222  [3]
 LDCM0344  AC79 PaTu 8988t C100(1.55)  LDD1223  [3]
 LDCM0345  AC8 PaTu 8988t C100(1.02)  LDD1224  [3]
 LDCM0346  AC80 PaTu 8988t C100(1.22)  LDD1225  [3]
 LDCM0347  AC81 PaTu 8988t C100(1.60)  LDD1226  [3]
 LDCM0348  AC82 PaTu 8988t C100(1.49)  LDD1227  [3]
 LDCM0349  AC83 PaTu 8988t C100(0.92)  LDD1228  [3]
 LDCM0350  AC84 PaTu 8988t C100(0.83)  LDD1229  [3]
 LDCM0351  AC85 PaTu 8988t C100(1.06)  LDD1230  [3]
 LDCM0352  AC86 PaTu 8988t C100(1.00)  LDD1231  [3]
 LDCM0353  AC87 PaTu 8988t C100(0.96)  LDD1232  [3]
 LDCM0354  AC88 PaTu 8988t C100(0.95)  LDD1233  [3]
 LDCM0355  AC89 PaTu 8988t C100(0.84)  LDD1234  [3]
 LDCM0357  AC90 PaTu 8988t C100(0.95)  LDD1236  [3]
 LDCM0358  AC91 PaTu 8988t C100(0.92)  LDD1237  [3]
 LDCM0359  AC92 PaTu 8988t C100(0.92)  LDD1238  [3]
 LDCM0360  AC93 PaTu 8988t C100(0.84)  LDD1239  [3]
 LDCM0361  AC94 PaTu 8988t C100(0.87)  LDD1240  [3]
 LDCM0362  AC95 PaTu 8988t C100(0.85)  LDD1241  [3]
 LDCM0363  AC96 PaTu 8988t C100(0.77)  LDD1242  [3]
 LDCM0364  AC97 PaTu 8988t C100(0.74)  LDD1243  [3]
 LDCM0248  AKOS034007472 PaTu 8988t C100(1.06)  LDD1127  [3]
 LDCM0356  AKOS034007680 PaTu 8988t C100(1.47)  LDD1235  [3]
 LDCM0275  AKOS034007705 PaTu 8988t C100(1.11)  LDD1154  [3]
 LDCM0156  Aniline NCI-H1299 11.68  LDD0403  [1]
 LDCM0020  ARS-1620 HCC44 C100(0.95)  LDD0078  [3]
 LDCM0108  Chloroacetamide HeLa N.A.  LDD0222  [8]
 LDCM0367  CL1 HEK-293T C100(0.89); C123(1.04); C15(0.90)  LDD1571  [10]
 LDCM0368  CL10 HEK-293T C100(1.13); C123(0.96)  LDD1572  [10]
 LDCM0369  CL100 HEK-293T C100(1.05); C123(0.92)  LDD1573  [10]
 LDCM0370  CL101 PaTu 8988t C100(1.21)  LDD1249  [3]
 LDCM0371  CL102 PaTu 8988t C100(1.19)  LDD1250  [3]
 LDCM0372  CL103 PaTu 8988t C100(1.34)  LDD1251  [3]
 LDCM0373  CL104 PaTu 8988t C100(1.18)  LDD1252  [3]
 LDCM0374  CL105 PaTu 8988t C100(1.05)  LDD1253  [3]
 LDCM0375  CL106 PaTu 8988t C100(0.96)  LDD1254  [3]
 LDCM0376  CL107 PaTu 8988t C100(1.09)  LDD1255  [3]
 LDCM0377  CL108 PaTu 8988t C100(1.27)  LDD1256  [3]
 LDCM0378  CL109 PaTu 8988t C100(1.26)  LDD1257  [3]
 LDCM0379  CL11 HEK-293T C100(1.09); C123(0.92)  LDD1583  [10]
 LDCM0380  CL110 PaTu 8988t C100(1.60)  LDD1259  [3]
 LDCM0381  CL111 PaTu 8988t C100(1.66)  LDD1260  [3]
 LDCM0382  CL112 PaTu 8988t C100(1.35)  LDD1261  [3]
 LDCM0383  CL113 PaTu 8988t C100(1.24)  LDD1262  [3]
 LDCM0384  CL114 PaTu 8988t C100(0.96)  LDD1263  [3]
 LDCM0385  CL115 PaTu 8988t C100(1.09)  LDD1264  [3]
 LDCM0386  CL116 PaTu 8988t C100(1.50)  LDD1265  [3]
 LDCM0387  CL117 PaTu 8988t C100(1.06)  LDD1266  [3]
 LDCM0388  CL118 PaTu 8988t C100(1.07)  LDD1267  [3]
 LDCM0389  CL119 PaTu 8988t C100(1.21)  LDD1268  [3]
 LDCM0390  CL12 HEK-293T C100(1.18); C123(0.94)  LDD1594  [10]
 LDCM0391  CL120 PaTu 8988t C100(1.39)  LDD1270  [3]
 LDCM0392  CL121 PaTu 8988t C100(1.31)  LDD1271  [3]
 LDCM0393  CL122 PaTu 8988t C100(1.76)  LDD1272  [3]
 LDCM0394  CL123 PaTu 8988t C100(1.58)  LDD1273  [3]
 LDCM0395  CL124 PaTu 8988t C100(1.18)  LDD1274  [3]
 LDCM0396  CL125 PaTu 8988t C100(0.97)  LDD1275  [3]
 LDCM0397  CL126 PaTu 8988t C100(1.06)  LDD1276  [3]
 LDCM0398  CL127 PaTu 8988t C100(1.21)  LDD1277  [3]
 LDCM0399  CL128 PaTu 8988t C100(1.23)  LDD1278  [3]
 LDCM0400  CL13 HEK-293T C100(1.01); C123(1.20); C15(0.77)  LDD1604  [10]
 LDCM0401  CL14 HEK-293T C100(1.18); C123(0.93)  LDD1605  [10]
 LDCM0402  CL15 HEK-293T C100(1.18); C123(1.00)  LDD1606  [10]
 LDCM0403  CL16 PaTu 8988t C100(1.16)  LDD1282  [3]
 LDCM0404  CL17 PaTu 8988t C100(1.15)  LDD1283  [3]
 LDCM0405  CL18 PaTu 8988t C100(1.18)  LDD1284  [3]
 LDCM0406  CL19 PaTu 8988t C100(1.00)  LDD1285  [3]
 LDCM0407  CL2 HEK-293T C100(1.08); C123(0.94)  LDD1611  [10]
 LDCM0408  CL20 PaTu 8988t C100(1.23)  LDD1287  [3]
 LDCM0409  CL21 PaTu 8988t C100(1.30)  LDD1288  [3]
 LDCM0410  CL22 PaTu 8988t C100(1.25)  LDD1289  [3]
 LDCM0411  CL23 PaTu 8988t C100(1.15)  LDD1290  [3]
 LDCM0412  CL24 PaTu 8988t C100(0.96)  LDD1291  [3]
 LDCM0413  CL25 PaTu 8988t C100(0.96)  LDD1292  [3]
 LDCM0414  CL26 PaTu 8988t C100(1.13)  LDD1293  [3]
 LDCM0415  CL27 PaTu 8988t C100(0.98)  LDD1294  [3]
 LDCM0416  CL28 PaTu 8988t C100(1.24)  LDD1295  [3]
 LDCM0417  CL29 PaTu 8988t C100(1.16)  LDD1296  [3]
 LDCM0418  CL3 HEK-293T C100(1.01); C123(0.88)  LDD1622  [10]
 LDCM0419  CL30 PaTu 8988t C100(1.17)  LDD1298  [3]
 LDCM0420  CL31 PaTu 8988t C100(1.08)  LDD1299  [3]
 LDCM0421  CL32 PaTu 8988t C100(1.51)  LDD1300  [3]
 LDCM0422  CL33 PaTu 8988t C100(1.71)  LDD1301  [3]
 LDCM0423  CL34 PaTu 8988t C100(1.62)  LDD1302  [3]
 LDCM0424  CL35 PaTu 8988t C100(1.43)  LDD1303  [3]
 LDCM0425  CL36 PaTu 8988t C100(1.50)  LDD1304  [3]
 LDCM0426  CL37 PaTu 8988t C100(1.83)  LDD1305  [3]
 LDCM0428  CL39 PaTu 8988t C100(1.72)  LDD1307  [3]
 LDCM0429  CL4 HEK-293T C100(0.98); C123(0.89)  LDD1633  [10]
 LDCM0430  CL40 PaTu 8988t C100(1.75)  LDD1309  [3]
 LDCM0431  CL41 PaTu 8988t C100(1.82)  LDD1310  [3]
 LDCM0432  CL42 PaTu 8988t C100(2.18)  LDD1311  [3]
 LDCM0433  CL43 PaTu 8988t C100(2.51)  LDD1312  [3]
 LDCM0434  CL44 PaTu 8988t C100(1.82)  LDD1313  [3]
 LDCM0435  CL45 PaTu 8988t C100(1.55)  LDD1314  [3]
 LDCM0436  CL46 PaTu 8988t C100(1.10)  LDD1315  [3]
 LDCM0437  CL47 PaTu 8988t C100(1.30)  LDD1316  [3]
 LDCM0438  CL48 PaTu 8988t C100(1.29)  LDD1317  [3]
 LDCM0439  CL49 PaTu 8988t C100(1.19)  LDD1318  [3]
 LDCM0440  CL5 HEK-293T C100(0.92); C123(1.01)  LDD1644  [10]
 LDCM0441  CL50 PaTu 8988t C100(1.17)  LDD1320  [3]
 LDCM0442  CL51 PaTu 8988t C100(1.16)  LDD1321  [3]
 LDCM0443  CL52 PaTu 8988t C100(1.16)  LDD1322  [3]
 LDCM0444  CL53 PaTu 8988t C100(1.44)  LDD1323  [3]
 LDCM0445  CL54 PaTu 8988t C100(1.45)  LDD1324  [3]
 LDCM0446  CL55 PaTu 8988t C100(1.41)  LDD1325  [3]
 LDCM0447  CL56 PaTu 8988t C100(0.72)  LDD1326  [3]
 LDCM0448  CL57 PaTu 8988t C100(1.54)  LDD1327  [3]
 LDCM0449  CL58 PaTu 8988t C100(1.36)  LDD1328  [3]
 LDCM0450  CL59 PaTu 8988t C100(1.62)  LDD1329  [3]
 LDCM0451  CL6 HEK-293T C100(0.93); C123(0.94)  LDD1654  [10]
 LDCM0452  CL60 PaTu 8988t C100(1.76)  LDD1331  [3]
 LDCM0453  CL61 HEK-293T C100(0.91); C123(1.01); C15(1.19)  LDD1656  [10]
 LDCM0454  CL62 HEK-293T C100(1.01); C123(1.01)  LDD1657  [10]
 LDCM0455  CL63 HEK-293T C100(1.00); C123(1.00)  LDD1658  [10]
 LDCM0456  CL64 HEK-293T C100(1.07); C123(0.98)  LDD1659  [10]
 LDCM0457  CL65 HEK-293T C100(1.00); C123(1.09)  LDD1660  [10]
 LDCM0458  CL66 HEK-293T C100(0.91); C123(0.99)  LDD1661  [10]
 LDCM0459  CL67 HEK-293T C100(0.98); C123(1.00)  LDD1662  [10]
 LDCM0460  CL68 HEK-293T C100(0.92); C123(1.03)  LDD1663  [10]
 LDCM0461  CL69 HEK-293T C100(1.05); C123(1.03)  LDD1664  [10]
 LDCM0462  CL7 HEK-293T C100(1.14); C123(0.93)  LDD1665  [10]
 LDCM0463  CL70 HEK-293T C100(1.09); C123(1.00)  LDD1666  [10]
 LDCM0464  CL71 HEK-293T C100(1.10); C123(1.07)  LDD1667  [10]
 LDCM0465  CL72 HEK-293T C100(1.07); C123(1.04)  LDD1668  [10]
 LDCM0466  CL73 HEK-293T C100(0.90); C123(1.04); C15(1.09)  LDD1669  [10]
 LDCM0467  CL74 HEK-293T C100(1.01); C123(0.98)  LDD1670  [10]
 LDCM0469  CL76 PaTu 8988t C100(1.05)  LDD1348  [3]
 LDCM0470  CL77 PaTu 8988t C100(0.99)  LDD1349  [3]
 LDCM0471  CL78 PaTu 8988t C100(1.47)  LDD1350  [3]
 LDCM0472  CL79 PaTu 8988t C100(1.24)  LDD1351  [3]
 LDCM0473  CL8 HEK-293T C100(0.88); C123(0.99)  LDD1676  [10]
 LDCM0474  CL80 PaTu 8988t C100(1.07)  LDD1353  [3]
 LDCM0475  CL81 PaTu 8988t C100(1.25)  LDD1354  [3]
 LDCM0476  CL82 PaTu 8988t C100(1.40)  LDD1355  [3]
 LDCM0477  CL83 PaTu 8988t C100(1.38)  LDD1356  [3]
 LDCM0478  CL84 PaTu 8988t C100(0.92)  LDD1357  [3]
 LDCM0479  CL85 PaTu 8988t C100(1.08)  LDD1358  [3]
 LDCM0480  CL86 PaTu 8988t C100(1.14)  LDD1359  [3]
 LDCM0481  CL87 PaTu 8988t C100(1.27)  LDD1360  [3]
 LDCM0482  CL88 PaTu 8988t C100(1.62)  LDD1361  [3]
 LDCM0483  CL89 PaTu 8988t C100(1.20)  LDD1362  [3]
 LDCM0484  CL9 HEK-293T C100(1.08); C123(0.92)  LDD1687  [10]
 LDCM0485  CL90 PaTu 8988t C100(1.34)  LDD1364  [3]
 LDCM0486  CL91 HEK-293T C100(1.04); C123(1.01)  LDD1689  [10]
 LDCM0487  CL92 HEK-293T C100(1.10); C123(1.00)  LDD1690  [10]
 LDCM0488  CL93 HEK-293T C100(1.05); C123(1.03)  LDD1691  [10]
 LDCM0489  CL94 HEK-293T C100(1.09); C123(1.00)  LDD1692  [10]
 LDCM0490  CL95 HEK-293T C100(1.14); C123(1.04)  LDD1693  [10]
 LDCM0491  CL96 HEK-293T C100(0.92); C123(0.97)  LDD1694  [10]
 LDCM0492  CL97 HEK-293T C100(0.89); C123(0.97); C15(1.03)  LDD1695  [10]
 LDCM0493  CL98 HEK-293T C100(1.09); C123(1.02)  LDD1696  [10]
 LDCM0494  CL99 HEK-293T C100(1.08); C123(0.94)  LDD1697  [10]
 LDCM0495  E2913 HEK-293T C100(1.11); C123(0.94)  LDD1698  [10]
 LDCM0625  F8 Ramos C100(1.05)  LDD2187  [11]
 LDCM0574  Fragment12 Ramos C100(1.60)  LDD2191  [11]
 LDCM0575  Fragment13 Ramos C100(1.07)  LDD2192  [11]
 LDCM0579  Fragment20 Ramos C100(1.53)  LDD2194  [11]
 LDCM0580  Fragment21 Ramos C100(2.05)  LDD2195  [11]
 LDCM0582  Fragment23 Ramos C100(1.25)  LDD2196  [11]
 LDCM0578  Fragment27 Ramos C100(1.46)  LDD2197  [11]
 LDCM0586  Fragment28 Ramos C100(0.72)  LDD2198  [11]
 LDCM0588  Fragment30 Ramos C100(1.18)  LDD2199  [11]
 LDCM0589  Fragment31 Ramos C100(1.36)  LDD2200  [11]
 LDCM0590  Fragment32 Ramos C100(3.00)  LDD2201  [11]
 LDCM0468  Fragment33 HEK-293T C100(1.01); C123(1.02)  LDD1671  [10]
 LDCM0596  Fragment38 Ramos C100(1.58)  LDD2203  [11]
 LDCM0427  Fragment51 PaTu 8988t C100(2.50)  LDD1306  [3]
 LDCM0610  Fragment52 Ramos C100(1.54)  LDD2204  [11]
 LDCM0614  Fragment56 Ramos C100(1.26)  LDD2205  [11]
 LDCM0569  Fragment7 Ramos C100(1.38)  LDD2186  [11]
 LDCM0571  Fragment9 Ramos C100(1.32)  LDD2188  [11]
 LDCM0107  IAA HeLa H66(0.00); H26(0.00); H91(0.00)  LDD0221  [8]
 LDCM0022  KB02 HCT 116 C100(3.16)  LDD0080  [3]
 LDCM0023  KB03 HCT 116 C100(1.75)  LDD0081  [3]
 LDCM0024  KB05 HCT 116 C100(1.45)  LDD0082  [3]
 LDCM0109  NEM HeLa N.A.  LDD0223  [8]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 3 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
E3 ubiquitin-protein ligase Mdm2 (MDM2) MDM2/MDM4 family Q00987
E3 ubiquitin-protein ligase TRIP12 (TRIP12) UPL family Q14669
E3 ubiquitin-protein ligase HUWE1 (HUWE1) UPL family Q7Z6Z7
Transporter and channel
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Complement component 1 Q subcomponent-binding protein, mitochondrial (C1QBP) MAM33 family Q07021
Transcription factor
Click To Hide/Show 5 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Early growth response protein 1 (EGR1) EGR C2H2-type zinc-finger protein family P18146
Transcription factor Sp1 (SP1) Sp1 C2H2-type zinc-finger protein family P08047
Metastasis-associated protein MTA1 (MTA1) . Q13330
N-myc proto-oncogene protein (MYCN) . P04198
Zinc finger protein 420 (ZNF420) . Q8TAQ5
Other
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Death domain-associated protein 6 (DAXX) DAXX family Q9UER7
Nucleophosmin (NPM1) Nucleoplasmin family P06748

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
3 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
4 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
5 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
6 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
7 DFT-Guided Discovery of Ethynyl-Triazolyl-Phosphinates as Modular Electrophiles for Chemoselective Cysteine Bioconjugation and Profiling. Angew Chem Int Ed Engl. 2022 Oct 10;61(41):e202205348. doi: 10.1002/anie.202205348. Epub 2022 Aug 22.
Mass spectrometry data entry: PXD033004
8 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
9 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
10 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
11 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578