Details of the Target

General Information of Target

Target ID LDTP08895
Target Name NF-kappa-B-activating protein (NKAP)
Gene Name NKAP
Gene ID 79576
Synonyms
NF-kappa-B-activating protein
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MAPVSGSRSPDREASGSGGRRRSSSKSPKPSKSARSPRGRRSRSHSCSRSGDRNGLTHQL
GGLSQGSRNQSYRSRSRSRSRERPSAPRGIPFASASSSVYYGSYSRPYGSDKPWPSLLDK
EREESLRQKRLSERERIGELGAPEVWGLSPKNPEPDSDEHTPVEDEEPKKSTTSASTSEE
EKKKKSSRSKERSKKRRKKKSSKRKHKKYSEDSDSDSDSETDSSDEDNKRRAKKAKKKEK
KKKHRSKKYKKKRSKKSRKESSDSSSKESQEEFLENPWKDRTKAEEPSDLIGPEAPKTLT
SQDDKPLNYGHALLPGEGAAMAEYVKAGKRIPRRGEIGLTSEEIASFECSGYVMSGSRHR
RMEAVRLRKENQIYSADEKRALASFNQEERRKRENKILASFREMVYRKTKGKDDK
Target Bioclass
Other
Family
NKAP family
Subcellular location
Nucleus
Function
Acts as a transcriptional repressor. Plays a role as a transcriptional corepressor of the Notch-mediated signaling required for T-cell development. Also involved in the TNF and IL-1 induced NF-kappa-B activation. Associates with chromatin at the Notch-regulated SKP2 promoter.
Uniprot ID
Q8N5F7
Ensemble ID
ENST00000371410.5
HGNC ID
HGNC:29873

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 13 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C-Sul
 Probe Info  		2.29  LDD0066  [1]
AHL-Pu-1
 Probe Info  		C349(3.94)  LDD0168  [2]
DBIA
 Probe Info  		C349(1.25)  LDD0080  [3]
m-APA
 Probe Info  		N.A.  LDD2231  [4]
NAIA_5
 Probe Info  		N.A.  LDD2224  [5]
Compound 10
 Probe Info  		N.A.  LDD2216  [6]
IA-alkyne
 Probe Info  		N.A.  LDD0150  [7]
IPM
 Probe Info  		N.A.  LDD0147  [8]
TFBX
 Probe Info  		N.A.  LDD0148  [8]
Phosphinate-6
 Probe Info  		C349(0.00); C47(0.00)  LDD0018  [9]
AOyne
 Probe Info  		10.70  LDD0443  [10]
HHS-465
 Probe Info  		K326(0.00); Y324(0.00)  LDD2240  [11]
HHS-482
 Probe Info  		Y309(0.87)  LDD2239  [12]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0025  4SU-RNA HEK-293T C349(3.94)  LDD0168  [2]
 LDCM0026  4SU-RNA+native RNA HEK-293T C47(2.44); C349(3.17)  LDD0169  [2]
 LDCM0214  AC1 HEK-293T C349(1.10)  LDD1507  [13]
 LDCM0215  AC10 HEK-293T C349(1.00)  LDD1508  [13]
 LDCM0226  AC11 HEK-293T C349(1.19)  LDD1509  [13]
 LDCM0237  AC12 HEK-293T C349(0.94)  LDD1510  [13]
 LDCM0259  AC14 HEK-293T C349(0.90)  LDD1512  [13]
 LDCM0263  AC143 HEK-293T C349(1.16)  LDD0861  [3]
 LDCM0264  AC144 HEK-293T C349(1.39)  LDD0862  [3]
 LDCM0265  AC145 HEK-293T C349(1.51)  LDD0863  [3]
 LDCM0266  AC146 HEK-293T C349(1.44)  LDD0864  [3]
 LDCM0267  AC147 HEK-293T C349(1.50)  LDD0865  [3]
 LDCM0268  AC148 HEK-293T C349(2.03)  LDD0866  [3]
 LDCM0269  AC149 HEK-293T C349(1.13)  LDD0867  [3]
 LDCM0270  AC15 HEK-293T C349(1.10)  LDD1513  [13]
 LDCM0271  AC150 HEK-293T C349(1.19)  LDD0869  [3]
 LDCM0272  AC151 HEK-293T C349(1.41)  LDD0870  [3]
 LDCM0273  AC152 HEK-293T C349(1.43)  LDD0871  [3]
 LDCM0274  AC153 HEK-293T C349(1.34)  LDD0872  [3]
 LDCM0621  AC154 HEK-293T C349(1.07)  LDD2162  [3]
 LDCM0622  AC155 HEK-293T C349(1.48)  LDD2163  [3]
 LDCM0623  AC156 HEK-293T C349(1.60)  LDD2164  [3]
 LDCM0624  AC157 HEK-293T C349(1.94)  LDD2165  [3]
 LDCM0276  AC17 HEK-293T C349(0.93)  LDD1515  [13]
 LDCM0277  AC18 HEK-293T C349(1.08)  LDD1516  [13]
 LDCM0278  AC19 HEK-293T C349(1.21)  LDD1517  [13]
 LDCM0279  AC2 HEK-293T C349(0.92)  LDD1518  [13]
 LDCM0280  AC20 HEK-293T C349(1.06)  LDD1519  [13]
 LDCM0281  AC21 HEK-293T C349(1.11)  LDD1520  [13]
 LDCM0282  AC22 HEK-293T C349(0.99)  LDD1521  [13]
 LDCM0283  AC23 HEK-293T C349(1.03)  LDD1522  [13]
 LDCM0284  AC24 HEK-293T C349(1.05)  LDD1523  [13]
 LDCM0285  AC25 HEK-293T C349(1.23)  LDD1524  [13]
 LDCM0286  AC26 HEK-293T C349(1.13)  LDD1525  [13]
 LDCM0287  AC27 HEK-293T C349(1.07)  LDD1526  [13]
 LDCM0288  AC28 HEK-293T C349(1.22)  LDD1527  [13]
 LDCM0289  AC29 HEK-293T C349(0.96)  LDD1528  [13]
 LDCM0290  AC3 HEK-293T C349(0.97)  LDD1529  [13]
 LDCM0291  AC30 HEK-293T C349(0.94)  LDD1530  [13]
 LDCM0292  AC31 HEK-293T C349(1.52)  LDD1531  [13]
 LDCM0293  AC32 HEK-293T C349(1.08)  LDD1532  [13]
 LDCM0294  AC33 HEK-293T C349(0.80)  LDD1533  [13]
 LDCM0295  AC34 HEK-293T C349(1.14)  LDD1534  [13]
 LDCM0296  AC35 HEK-293T C349(1.06)  LDD1535  [13]
 LDCM0297  AC36 HEK-293T C349(1.01)  LDD1536  [13]
 LDCM0298  AC37 HEK-293T C349(0.90)  LDD1537  [13]
 LDCM0299  AC38 HEK-293T C349(1.13)  LDD1538  [13]
 LDCM0300  AC39 HEK-293T C349(1.11)  LDD1539  [13]
 LDCM0301  AC4 HEK-293T C349(0.93)  LDD1540  [13]
 LDCM0302  AC40 HEK-293T C349(0.88)  LDD1541  [13]
 LDCM0303  AC41 HEK-293T C349(1.20)  LDD1542  [13]
 LDCM0304  AC42 HEK-293T C349(1.34)  LDD1543  [13]
 LDCM0305  AC43 HEK-293T C349(1.08)  LDD1544  [13]
 LDCM0306  AC44 HEK-293T C349(0.92)  LDD1545  [13]
 LDCM0307  AC45 HEK-293T C349(1.24)  LDD1546  [13]
 LDCM0308  AC46 HEK-293T C349(1.20)  LDD0906  [3]
 LDCM0309  AC47 HEK-293T C349(1.62)  LDD0907  [3]
 LDCM0310  AC48 HEK-293T C349(1.55)  LDD0908  [3]
 LDCM0311  AC49 HEK-293T C349(1.20)  LDD0909  [3]
 LDCM0312  AC5 HEK-293T C349(0.93)  LDD1551  [13]
 LDCM0313  AC50 HEK-293T C349(1.44)  LDD0911  [3]
 LDCM0314  AC51 HEK-293T C349(1.60)  LDD0912  [3]
 LDCM0315  AC52 HEK-293T C349(1.17)  LDD0913  [3]
 LDCM0316  AC53 HEK-293T C349(1.19)  LDD0914  [3]
 LDCM0317  AC54 HEK-293T C349(1.25)  LDD0915  [3]
 LDCM0318  AC55 HEK-293T C349(1.65)  LDD0916  [3]
 LDCM0319  AC56 HEK-293T C349(1.44)  LDD0917  [3]
 LDCM0320  AC57 HEK-293T C349(1.04)  LDD0918  [3]
 LDCM0321  AC58 HEK-293T C349(0.95)  LDD0919  [3]
 LDCM0322  AC59 HEK-293T C349(0.88)  LDD0920  [3]
 LDCM0323  AC6 HEK-293T C349(1.05)  LDD1562  [13]
 LDCM0324  AC60 HEK-293T C349(0.91)  LDD0922  [3]
 LDCM0325  AC61 HEK-293T C349(2.01)  LDD0923  [3]
 LDCM0326  AC62 HEK-293T C349(1.05)  LDD0924  [3]
 LDCM0327  AC63 HEK-293T C349(1.15)  LDD0925  [3]
 LDCM0328  AC64 HEK-293T C349(0.91)  LDD0926  [3]
 LDCM0329  AC65 HEK-293T C349(1.03)  LDD0927  [3]
 LDCM0330  AC66 HEK-293T C349(0.85)  LDD0928  [3]
 LDCM0331  AC67 HEK-293T C349(0.93)  LDD0929  [3]
 LDCM0334  AC7 HEK-293T C349(1.05)  LDD1568  [13]
 LDCM0345  AC8 HEK-293T C349(1.13)  LDD1569  [13]
 LDCM0349  AC83 HEK-293T C349(0.75)  LDD0947  [3]
 LDCM0350  AC84 HEK-293T C349(1.03)  LDD0948  [3]
 LDCM0351  AC85 HEK-293T C349(0.82)  LDD0949  [3]
 LDCM0352  AC86 HEK-293T C349(0.76)  LDD0950  [3]
 LDCM0353  AC87 HEK-293T C349(0.85)  LDD0951  [3]
 LDCM0354  AC88 HEK-293T C349(0.75)  LDD0952  [3]
 LDCM0355  AC89 HEK-293T C349(0.97)  LDD0953  [3]
 LDCM0357  AC90 HEK-293T C349(0.99)  LDD0955  [3]
 LDCM0358  AC91 HEK-293T C349(1.18)  LDD0956  [3]
 LDCM0359  AC92 HEK-293T C349(0.72)  LDD0957  [3]
 LDCM0360  AC93 HEK-293T C349(0.86)  LDD0958  [3]
 LDCM0361  AC94 HEK-293T C349(0.78)  LDD0959  [3]
 LDCM0362  AC95 HEK-293T C349(0.84)  LDD0960  [3]
 LDCM0363  AC96 HEK-293T C349(0.84)  LDD0961  [3]
 LDCM0364  AC97 HEK-293T C349(1.34)  LDD0962  [3]
 LDCM0248  AKOS034007472 HEK-293T C349(1.19)  LDD1511  [13]
 LDCM0356  AKOS034007680 HEK-293T C349(0.82)  LDD1570  [13]
 LDCM0275  AKOS034007705 HEK-293T C349(1.10)  LDD1514  [13]
 LDCM0367  CL1 HEK-293T C349(0.94)  LDD1571  [13]
 LDCM0368  CL10 HEK-293T C349(1.02)  LDD1572  [13]
 LDCM0369  CL100 HEK-293T C349(1.03)  LDD1573  [13]
 LDCM0370  CL101 HEK-293T C349(1.31)  LDD1574  [13]
 LDCM0372  CL103 HEK-293T C349(0.97)  LDD1576  [13]
 LDCM0373  CL104 HEK-293T C349(1.41)  LDD1577  [13]
 LDCM0374  CL105 HEK-293T C349(1.15)  LDD1578  [13]
 LDCM0376  CL107 HEK-293T C349(0.99)  LDD1580  [13]
 LDCM0377  CL108 HEK-293T C349(1.52)  LDD1581  [13]
 LDCM0378  CL109 HEK-293T C349(0.92)  LDD1582  [13]
 LDCM0379  CL11 HEK-293T C349(1.02)  LDD1583  [13]
 LDCM0381  CL111 HEK-293T C349(0.96)  LDD1585  [13]
 LDCM0382  CL112 HEK-293T C349(0.82)  LDD1586  [13]
 LDCM0383  CL113 HEK-293T C349(0.85)  LDD1587  [13]
 LDCM0385  CL115 HEK-293T C349(1.00)  LDD1589  [13]
 LDCM0386  CL116 HEK-293T C349(0.86)  LDD1590  [13]
 LDCM0387  CL117 HEK-293T C349(1.00)  LDD1591  [13]
 LDCM0389  CL119 HEK-293T C349(1.23)  LDD1593  [13]
 LDCM0390  CL12 HEK-293T C349(0.86)  LDD1594  [13]
 LDCM0391  CL120 HEK-293T C349(1.41)  LDD1595  [13]
 LDCM0392  CL121 HEK-293T C349(1.26)  LDD0990  [3]
 LDCM0393  CL122 HEK-293T C349(1.34)  LDD0991  [3]
 LDCM0394  CL123 HEK-293T C349(2.82)  LDD0992  [3]
 LDCM0395  CL124 HEK-293T C349(1.27)  LDD0993  [3]
 LDCM0396  CL125 HEK-293T C349(0.94)  LDD0994  [3]
 LDCM0397  CL126 HEK-293T C349(1.52)  LDD0995  [3]
 LDCM0398  CL127 HEK-293T C349(1.15)  LDD0996  [3]
 LDCM0399  CL128 HEK-293T C349(0.97)  LDD0997  [3]
 LDCM0400  CL13 HEK-293T C349(1.09)  LDD1604  [13]
 LDCM0402  CL15 HEK-293T C349(0.82)  LDD1606  [13]
 LDCM0403  CL16 HEK-293T C349(1.10)  LDD1607  [13]
 LDCM0404  CL17 HEK-293T C349(1.21)  LDD1608  [13]
 LDCM0405  CL18 HEK-293T C349(1.05)  LDD1609  [13]
 LDCM0406  CL19 HEK-293T C349(0.85)  LDD1610  [13]
 LDCM0408  CL20 HEK-293T C349(0.98)  LDD1612  [13]
 LDCM0409  CL21 HEK-293T C349(1.00)  LDD1613  [13]
 LDCM0410  CL22 HEK-293T C349(0.83)  LDD1614  [13]
 LDCM0411  CL23 HEK-293T C349(1.22)  LDD1615  [13]
 LDCM0412  CL24 HEK-293T C349(0.95)  LDD1616  [13]
 LDCM0413  CL25 HEK-293T C349(1.21)  LDD1617  [13]
 LDCM0415  CL27 HEK-293T C349(0.95)  LDD1619  [13]
 LDCM0416  CL28 HEK-293T C349(1.10)  LDD1620  [13]
 LDCM0417  CL29 HEK-293T C349(1.22)  LDD1621  [13]
 LDCM0418  CL3 HEK-293T C349(0.87)  LDD1622  [13]
 LDCM0419  CL30 HEK-293T C349(1.02)  LDD1623  [13]
 LDCM0420  CL31 HEK-293T C349(0.84)  LDD1624  [13]
 LDCM0421  CL32 HEK-293T C349(0.94)  LDD1625  [13]
 LDCM0422  CL33 HEK-293T C349(0.89)  LDD1626  [13]
 LDCM0423  CL34 HEK-293T C349(0.93)  LDD1627  [13]
 LDCM0424  CL35 HEK-293T C349(0.95)  LDD1628  [13]
 LDCM0425  CL36 HEK-293T C349(0.87)  LDD1629  [13]
 LDCM0426  CL37 HEK-293T C349(1.12)  LDD1630  [13]
 LDCM0428  CL39 HEK-293T C349(1.10)  LDD1632  [13]
 LDCM0429  CL4 HEK-293T C349(1.11)  LDD1633  [13]
 LDCM0430  CL40 HEK-293T C349(0.89)  LDD1634  [13]
 LDCM0431  CL41 HEK-293T C349(1.06)  LDD1635  [13]
 LDCM0432  CL42 HEK-293T C349(1.09)  LDD1636  [13]
 LDCM0433  CL43 HEK-293T C349(1.11)  LDD1637  [13]
 LDCM0434  CL44 HEK-293T C349(0.79)  LDD1638  [13]
 LDCM0435  CL45 HEK-293T C349(0.96)  LDD1639  [13]
 LDCM0436  CL46 HEK-293T C349(0.85)  LDD1640  [13]
 LDCM0437  CL47 HEK-293T C349(0.92)  LDD1641  [13]
 LDCM0438  CL48 HEK-293T C349(1.09)  LDD1642  [13]
 LDCM0439  CL49 HEK-293T C349(1.06)  LDD1643  [13]
 LDCM0440  CL5 HEK-293T C349(1.01)  LDD1644  [13]
 LDCM0443  CL52 HEK-293T C349(1.02)  LDD1646  [13]
 LDCM0444  CL53 HEK-293T C349(0.88)  LDD1647  [13]
 LDCM0445  CL54 HEK-293T C349(0.99)  LDD1648  [13]
 LDCM0446  CL55 HEK-293T C349(1.30)  LDD1649  [13]
 LDCM0447  CL56 HEK-293T C349(0.90)  LDD1650  [13]
 LDCM0448  CL57 HEK-293T C349(1.13)  LDD1651  [13]
 LDCM0449  CL58 HEK-293T C349(1.03)  LDD1652  [13]
 LDCM0450  CL59 HEK-293T C349(1.14)  LDD1653  [13]
 LDCM0451  CL6 HEK-293T C349(1.00)  LDD1654  [13]
 LDCM0452  CL60 HEK-293T C349(1.04)  LDD1655  [13]
 LDCM0453  CL61 HEK-293T C349(1.35)  LDD1656  [13]
 LDCM0455  CL63 HEK-293T C349(1.11)  LDD1658  [13]
 LDCM0456  CL64 HEK-293T C349(1.20)  LDD1659  [13]
 LDCM0457  CL65 HEK-293T C349(1.16)  LDD1660  [13]
 LDCM0458  CL66 HEK-293T C349(1.15)  LDD1661  [13]
 LDCM0459  CL67 HEK-293T C349(0.85)  LDD1662  [13]
 LDCM0460  CL68 HEK-293T C349(0.97)  LDD1663  [13]
 LDCM0461  CL69 HEK-293T C349(0.93)  LDD1664  [13]
 LDCM0462  CL7 HEK-293T C349(1.01)  LDD1665  [13]
 LDCM0463  CL70 HEK-293T C349(0.98)  LDD1666  [13]
 LDCM0464  CL71 HEK-293T C349(0.84)  LDD1667  [13]
 LDCM0465  CL72 HEK-293T C349(1.05)  LDD1668  [13]
 LDCM0466  CL73 HEK-293T C349(1.15)  LDD1669  [13]
 LDCM0469  CL76 HEK-293T C349(1.48)  LDD1067  [3]
 LDCM0470  CL77 HEK-293T C349(0.97)  LDD1068  [3]
 LDCM0471  CL78 HEK-293T C349(1.82)  LDD1069  [3]
 LDCM0472  CL79 HEK-293T C349(1.07)  LDD1070  [3]
 LDCM0473  CL8 HEK-293T C349(1.15)  LDD1676  [13]
 LDCM0474  CL80 HEK-293T C349(1.03)  LDD1072  [3]
 LDCM0475  CL81 HEK-293T C349(1.37)  LDD1073  [3]
 LDCM0476  CL82 HEK-293T C349(1.42)  LDD1074  [3]
 LDCM0477  CL83 HEK-293T C349(1.07)  LDD1075  [3]
 LDCM0478  CL84 HEK-293T C349(1.44)  LDD1076  [3]
 LDCM0479  CL85 HEK-293T C349(0.79)  LDD1077  [3]
 LDCM0480  CL86 HEK-293T C349(1.44)  LDD1078  [3]
 LDCM0481  CL87 HEK-293T C349(1.24)  LDD1079  [3]
 LDCM0482  CL88 HEK-293T C349(1.30)  LDD1080  [3]
 LDCM0483  CL89 HEK-293T C349(1.16)  LDD1081  [3]
 LDCM0484  CL9 HEK-293T C349(1.58)  LDD1687  [13]
 LDCM0485  CL90 HEK-293T C349(1.18)  LDD1083  [3]
 LDCM0486  CL91 HEK-293T C349(0.96)  LDD1689  [13]
 LDCM0487  CL92 HEK-293T C349(0.95)  LDD1690  [13]
 LDCM0488  CL93 HEK-293T C349(1.03)  LDD1691  [13]
 LDCM0489  CL94 HEK-293T C349(1.08)  LDD1692  [13]
 LDCM0490  CL95 HEK-293T C349(1.01)  LDD1693  [13]
 LDCM0491  CL96 HEK-293T C349(1.21)  LDD1694  [13]
 LDCM0492  CL97 HEK-293T C349(1.15)  LDD1695  [13]
 LDCM0494  CL99 HEK-293T C349(0.86)  LDD1697  [13]
 LDCM0495  E2913 HEK-293T C349(1.06)  LDD1698  [13]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C47(1.15)  LDD1702  [14]
 LDCM0468  Fragment33 HEK-293T C349(0.92)  LDD1671  [13]
 LDCM0022  KB02 HCT 116 C349(1.25)  LDD0080  [3]
 LDCM0023  KB03 HCT 116 C349(1.08)  LDD0081  [3]
 LDCM0024  KB05 HCT 116 C349(1.57)  LDD0082  [3]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Probable ATP-dependent RNA helicase DDX41 (DDX41) DEAD box helicase family Q9UJV9
ATP-dependent RNA helicase DHX8 (DHX8) DEAD box helicase family Q14562
Transporter and channel
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
AP-1 complex subunit mu-1 (AP1M1) Adaptor complexes medium subunit family Q9BXS5
Other
Click To Hide/Show 4 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
RNA-binding motif protein, X-linked 2 (RBMX2) IST3 family Q9Y388
Pre-mRNA-processing factor 40 homolog A (PRPF40A) PRPF40 family O75400
Splicing factor U2AF 35 kDa subunit (U2AF1) Splicing factor SR family Q01081
U4/U6 small nuclear ribonucleoprotein Prp3 (PRPF3) . O43395

References

1 Low-Toxicity Sulfonium-Based Probes for Cysteine-Specific Profiling in Live Cells. Anal Chem. 2022 Mar 15;94(10):4366-4372. doi: 10.1021/acs.analchem.1c05129. Epub 2022 Mar 4.
2 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
3 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
4 Global profiling of functional histidines in live cells using small-molecule photosensitizer and chemical probe relay labelling. Nat Chem. 2024 Jun 4. doi: 10.1038/s41557-024-01545-6. Online ahead of print.
Mass spectrometry data entry: PXD042377
5 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
6 Multiplexed CuAAC Suzuki-Miyaura Labeling for Tandem Activity-Based Chemoproteomic Profiling. Anal Chem. 2021 Feb 2;93(4):2610-2618. doi: 10.1021/acs.analchem.0c04726. Epub 2021 Jan 20.
Mass spectrometry data entry: PXD022279
7 Sequence-Based Prediction of Cysteine Reactivity Using Machine Learning. Biochemistry. 2018 Jan 30;57(4):451-460. doi: 10.1021/acs.biochem.7b00897. Epub 2017 Oct 26.
8 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
9 DFT-Guided Discovery of Ethynyl-Triazolyl-Phosphinates as Modular Electrophiles for Chemoselective Cysteine Bioconjugation and Profiling. Angew Chem Int Ed Engl. 2022 Oct 10;61(41):e202205348. doi: 10.1002/anie.202205348. Epub 2022 Aug 22.
Mass spectrometry data entry: PXD033004
10 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
11 Global profiling identifies a stress-responsive tyrosine site on EDC3 regulating biomolecular condensate formation. Cell Chem Biol. 2022 Dec 15;29(12):1709-1720.e7. doi: 10.1016/j.chembiol.2022.11.008. Epub 2022 Dec 6.
Mass spectrometry data entry: PXD038010
12 Global targeting of functional tyrosines using sulfur-triazole exchange chemistry. Nat Chem Biol. 2020 Feb;16(2):150-159. doi: 10.1038/s41589-019-0404-5. Epub 2019 Nov 25.
13 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
14 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761