Details of the Target

General Information of Target

Target ID LDTP08883
Target Name Prolyl 3-hydroxylase OGFOD1 (OGFOD1)
Gene Name OGFOD1
Gene ID 55239
Synonyms
KIAA1612; TPA1; Prolyl 3-hydroxylase OGFOD1; EC 1.14.11.-; 2-oxoglutarate and iron-dependent oxygenase domain-containing protein 1; Termination and polyadenylation 1 homolog; uS12 prolyl 3-hydroxylase
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MNGKRPAEPGPARVGKKGKKEVMAEFSDAVTEETLKKQVAEAWSRRTPFSHEVIVMDMDP
FLHCVIPNFIQSQDFLEGLQKELMNLDFHEKYNDLYKFQQSDDLKKRREPHISTLRKILF
EDFRSWLSDISKIDLESTIDMSCAKYEFTDALLCHDDELEGRRIAFILYLVPPWDRSMGG
TLDLYSIDEHFQPKQIVKSLIPSWNKLVFFEVSPVSFHQVSEVLSEEKSRLSISGWFHGP
SLTRPPNYFEPPIPRSPHIPQDHEILYDWINPTYLDMDYQVQIQEEFEESSEILLKEFLK
PEKFTKVCEALEHGHVEWSSRGPPNKRFYEKAEESKLPEILKECMKLFRSEALFLLLSNF
TGLKLHFLAPSEEDEMNDKKEAETTDITEEGTSHSPPEPENNQMAISNNSQQSNEQTDPE
PEENETKKESSVPMCQGELRHWKTGHYTLIHDHSKAEFALDLILYCGCEGWEPEYGGFTS
YIAKGEDEELLTVNPESNSLALVYRDRETLKFVKHINHRSLEQKKTFPNRTGFWDFSFIY
YE
Target Bioclass
Enzyme
Family
TPA1 family
Subcellular location
Cytoplasm
Function
Prolyl 3-hydroxylase that catalyzes 3-hydroxylation of 'Pro-62' of small ribosomal subunit uS12 (RPS23), thereby regulating protein translation termination efficiency. Involved in stress granule formation.
Uniprot ID
Q8N543
Ensemble ID
ENST00000566157.6
HGNC ID
HGNC:25585
ChEMBL ID
CHEMBL4523398

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
HCT15 SNV: p.I253M .
SUPT1 SNV: p.T181A DBIA    Probe Info 

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 9 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C154(2.12)  LDD3323  [1]
BTD
 Probe Info  		C344(1.19)  LDD2140  [2]
IPM
 Probe Info  		C308(1.77)  LDD1702  [2]
Acrolein
 Probe Info  		N.A.  LDD0221  [3]
ATP probe
 Probe Info  		N.A.  LDD0199  [4]
4-Iodoacetamidophenylacetylene
 Probe Info  		C143(0.00); C308(0.00); C154(0.00); C64(0.00)  LDD0038  [5]
IA-alkyne
 Probe Info  		C435(0.00); C143(0.00); C64(0.00); C308(0.00)  LDD0036  [5]
Lodoacetamide azide
 Probe Info  		C308(0.00); C154(0.00); C143(0.00); C64(0.00)  LDD0037  [5]
NAIA_5
 Probe Info  		N.A.  LDD2223  [6]
PAL-AfBPP Probe
Click To Hide/Show 3 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
STS-2
 Probe Info  		N.A.  LDD0139  [7]
VE-P
 Probe Info  		N.A.  LDD0396  [8]
STS-1
 Probe Info  		N.A.  LDD0068  [9]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HEK-293T C435(0.95)  LDD1507  [10]
 LDCM0215  AC10 HEK-293T C435(1.11)  LDD0813  [11]
 LDCM0216  AC100 HEK-293T C435(0.75)  LDD0814  [11]
 LDCM0217  AC101 HEK-293T C435(0.70)  LDD0815  [11]
 LDCM0218  AC102 HEK-293T C435(0.55)  LDD0816  [11]
 LDCM0219  AC103 HEK-293T C435(0.80)  LDD0817  [11]
 LDCM0220  AC104 HEK-293T C435(0.67)  LDD0818  [11]
 LDCM0221  AC105 HEK-293T C435(1.15)  LDD0819  [11]
 LDCM0222  AC106 HEK-293T C435(0.93)  LDD0820  [11]
 LDCM0223  AC107 HEK-293T C435(0.51)  LDD0821  [11]
 LDCM0224  AC108 HEK-293T C435(0.64)  LDD0822  [11]
 LDCM0225  AC109 HEK-293T C435(0.50)  LDD0823  [11]
 LDCM0226  AC11 HEK-293T C435(1.03)  LDD0824  [11]
 LDCM0227  AC110 HEK-293T C435(1.12)  LDD0825  [11]
 LDCM0228  AC111 HEK-293T C435(1.40)  LDD0826  [11]
 LDCM0229  AC112 HEK-293T C435(0.91)  LDD0827  [11]
 LDCM0230  AC113 HEK-293T C435(1.08)  LDD0828  [11]
 LDCM0231  AC114 HEK-293T C435(1.01)  LDD0829  [11]
 LDCM0232  AC115 HEK-293T C435(1.15)  LDD0830  [11]
 LDCM0233  AC116 HEK-293T C435(0.84)  LDD0831  [11]
 LDCM0234  AC117 HEK-293T C435(1.29)  LDD0832  [11]
 LDCM0235  AC118 HEK-293T C435(1.28)  LDD0833  [11]
 LDCM0236  AC119 HEK-293T C435(1.30)  LDD0834  [11]
 LDCM0237  AC12 HEK-293T C435(1.35)  LDD0835  [11]
 LDCM0238  AC120 HEK-293T C435(1.15)  LDD0836  [11]
 LDCM0239  AC121 HEK-293T C435(1.23)  LDD0837  [11]
 LDCM0240  AC122 HEK-293T C435(1.38)  LDD0838  [11]
 LDCM0241  AC123 HEK-293T C435(1.41)  LDD0839  [11]
 LDCM0242  AC124 HEK-293T C435(1.07)  LDD0840  [11]
 LDCM0243  AC125 HEK-293T C435(1.52)  LDD0841  [11]
 LDCM0244  AC126 HEK-293T C435(1.39)  LDD0842  [11]
 LDCM0245  AC127 HEK-293T C435(1.52)  LDD0843  [11]
 LDCM0259  AC14 HEK-293T C435(1.36)  LDD0857  [11]
 LDCM0263  AC143 HEK-293T C435(0.82)  LDD0861  [11]
 LDCM0264  AC144 HEK-293T C435(1.18)  LDD0862  [11]
 LDCM0265  AC145 HEK-293T C435(1.28)  LDD0863  [11]
 LDCM0266  AC146 HEK-293T C435(1.14)  LDD0864  [11]
 LDCM0267  AC147 HEK-293T C435(1.09)  LDD0865  [11]
 LDCM0268  AC148 HEK-293T C435(1.17)  LDD0866  [11]
 LDCM0269  AC149 HEK-293T C435(0.93)  LDD0867  [11]
 LDCM0270  AC15 HEK-293T C435(1.02)  LDD0868  [11]
 LDCM0271  AC150 HEK-293T C435(1.23)  LDD0869  [11]
 LDCM0272  AC151 HEK-293T C435(1.28)  LDD0870  [11]
 LDCM0273  AC152 HEK-293T C435(0.96)  LDD0871  [11]
 LDCM0274  AC153 HEK-293T C435(1.04)  LDD0872  [11]
 LDCM0621  AC154 HEK-293T C435(0.93)  LDD2162  [11]
 LDCM0622  AC155 HEK-293T C435(0.82)  LDD2163  [11]
 LDCM0623  AC156 HEK-293T C435(1.34)  LDD2164  [11]
 LDCM0624  AC157 HEK-293T C435(1.47)  LDD2165  [11]
 LDCM0276  AC17 HEK-293T C435(0.67)  LDD0874  [11]
 LDCM0277  AC18 HEK-293T C435(0.74)  LDD0875  [11]
 LDCM0278  AC19 HEK-293T C435(0.72)  LDD0876  [11]
 LDCM0280  AC20 HEK-293T C435(0.59)  LDD0878  [11]
 LDCM0281  AC21 HEK-293T C435(0.62)  LDD0879  [11]
 LDCM0282  AC22 HEK-293T C435(0.75)  LDD0880  [11]
 LDCM0283  AC23 HEK-293T C435(0.54)  LDD0881  [11]
 LDCM0284  AC24 HEK-293T C435(0.75)  LDD0882  [11]
 LDCM0285  AC25 HEK-293T C435(1.03)  LDD0883  [11]
 LDCM0286  AC26 HEK-293T C435(1.02)  LDD0884  [11]
 LDCM0287  AC27 HEK-293T C435(0.91)  LDD0885  [11]
 LDCM0288  AC28 HEK-293T C435(1.31)  LDD0886  [11]
 LDCM0289  AC29 HEK-293T C435(0.84)  LDD0887  [11]
 LDCM0290  AC3 HEK-293T C308(0.90)  LDD1529  [10]
 LDCM0291  AC30 HEK-293T C435(0.85)  LDD0889  [11]
 LDCM0292  AC31 HEK-293T C435(0.95)  LDD0890  [11]
 LDCM0293  AC32 HEK-293T C435(1.03)  LDD0891  [11]
 LDCM0294  AC33 HEK-293T C435(0.91)  LDD0892  [11]
 LDCM0295  AC34 HEK-293T C435(0.84)  LDD0893  [11]
 LDCM0296  AC35 HEK-293T C308(0.91)  LDD1535  [10]
 LDCM0297  AC36 HEK-293T C308(1.04)  LDD1536  [10]
 LDCM0300  AC39 HEK-293T C435(1.17)  LDD1539  [10]
 LDCM0301  AC4 HEK-293T C308(0.95)  LDD1540  [10]
 LDCM0303  AC41 HEK-293T C435(0.83)  LDD1542  [10]
 LDCM0305  AC43 HEK-293T C308(0.91)  LDD1544  [10]
 LDCM0306  AC44 HEK-293T C308(1.07)  LDD1545  [10]
 LDCM0308  AC46 HEK-293T C435(1.18)  LDD0906  [11]
 LDCM0309  AC47 HEK-293T C435(0.58)  LDD0907  [11]
 LDCM0310  AC48 HEK-293T C435(0.64)  LDD0908  [11]
 LDCM0311  AC49 HEK-293T C435(0.56)  LDD0909  [11]
 LDCM0313  AC50 HEK-293T C435(0.47)  LDD0911  [11]
 LDCM0314  AC51 HEK-293T C435(0.86)  LDD0912  [11]
 LDCM0315  AC52 HEK-293T C435(0.58)  LDD0913  [11]
 LDCM0316  AC53 HEK-293T C435(0.56)  LDD0914  [11]
 LDCM0317  AC54 HEK-293T C435(0.61)  LDD0915  [11]
 LDCM0318  AC55 HEK-293T C435(0.62)  LDD0916  [11]
 LDCM0319  AC56 HEK-293T C435(0.67)  LDD0917  [11]
 LDCM0320  AC57 HEK-293T C435(1.00)  LDD0918  [11]
 LDCM0321  AC58 HEK-293T C435(0.85)  LDD0919  [11]
 LDCM0322  AC59 HEK-293T C435(0.93)  LDD0920  [11]
 LDCM0323  AC6 HEK-293T C435(1.10)  LDD0921  [11]
 LDCM0324  AC60 HEK-293T C435(1.11)  LDD0922  [11]
 LDCM0325  AC61 HEK-293T C435(0.84)  LDD0923  [11]
 LDCM0326  AC62 HEK-293T C435(0.67)  LDD0924  [11]
 LDCM0327  AC63 HEK-293T C435(0.77)  LDD0925  [11]
 LDCM0328  AC64 HEK-293T C435(0.80)  LDD0926  [11]
 LDCM0329  AC65 HEK-293T C435(0.78)  LDD0927  [11]
 LDCM0330  AC66 HEK-293T C435(0.99)  LDD0928  [11]
 LDCM0331  AC67 HEK-293T C435(0.79)  LDD0929  [11]
 LDCM0332  AC68 HEK-293T C435(1.03)  LDD0930  [11]
 LDCM0333  AC69 HEK-293T C435(1.27)  LDD0931  [11]
 LDCM0334  AC7 HEK-293T C435(1.02)  LDD0932  [11]
 LDCM0335  AC70 HEK-293T C435(0.95)  LDD0933  [11]
 LDCM0336  AC71 HEK-293T C435(1.15)  LDD0934  [11]
 LDCM0337  AC72 HEK-293T C435(1.09)  LDD0935  [11]
 LDCM0338  AC73 HEK-293T C435(1.10)  LDD0936  [11]
 LDCM0339  AC74 HEK-293T C435(1.19)  LDD0937  [11]
 LDCM0340  AC75 HEK-293T C435(0.95)  LDD0938  [11]
 LDCM0341  AC76 HEK-293T C435(1.04)  LDD0939  [11]
 LDCM0342  AC77 HEK-293T C435(1.43)  LDD0940  [11]
 LDCM0343  AC78 HEK-293T C435(1.06)  LDD0941  [11]
 LDCM0344  AC79 HEK-293T C435(1.25)  LDD0942  [11]
 LDCM0345  AC8 HEK-293T C435(1.09)  LDD0943  [11]
 LDCM0346  AC80 HEK-293T C435(1.11)  LDD0944  [11]
 LDCM0347  AC81 HEK-293T C435(1.11)  LDD0945  [11]
 LDCM0348  AC82 HEK-293T C435(1.25)  LDD0946  [11]
 LDCM0365  AC98 HEK-293T C435(0.77)  LDD0963  [11]
 LDCM0366  AC99 HEK-293T C435(0.54)  LDD0964  [11]
 LDCM0248  AKOS034007472 HEK-293T C435(1.21)  LDD0846  [11]
 LDCM0356  AKOS034007680 HEK-293T C435(1.36)  LDD0954  [11]
 LDCM0275  AKOS034007705 HEK-293T C435(1.21)  LDD0873  [11]
 LDCM0108  Chloroacetamide HeLa C154(0.00); C435(0.00); C143(0.00)  LDD0222  [3]
 LDCM0370  CL101 HEK-293T C435(1.11)  LDD0968  [11]
 LDCM0371  CL102 HEK-293T C435(0.81)  LDD0969  [11]
 LDCM0372  CL103 HEK-293T C435(1.19)  LDD0970  [11]
 LDCM0373  CL104 HEK-293T C435(0.99)  LDD0971  [11]
 LDCM0374  CL105 HEK-293T C435(0.79)  LDD0972  [11]
 LDCM0375  CL106 HEK-293T C435(0.79)  LDD0973  [11]
 LDCM0376  CL107 HEK-293T C435(0.97)  LDD0974  [11]
 LDCM0377  CL108 HEK-293T C435(0.80)  LDD0975  [11]
 LDCM0378  CL109 HEK-293T C435(0.87)  LDD0976  [11]
 LDCM0379  CL11 HEK-293T C435(1.14)  LDD1583  [10]
 LDCM0380  CL110 HEK-293T C435(0.80)  LDD0978  [11]
 LDCM0381  CL111 HEK-293T C435(0.88)  LDD0979  [11]
 LDCM0382  CL112 HEK-293T C435(0.88)  LDD0980  [11]
 LDCM0383  CL113 HEK-293T C435(1.14)  LDD0981  [11]
 LDCM0384  CL114 HEK-293T C435(1.25)  LDD0982  [11]
 LDCM0385  CL115 HEK-293T C435(1.03)  LDD0983  [11]
 LDCM0386  CL116 HEK-293T C435(1.12)  LDD0984  [11]
 LDCM0388  CL118 HEK-293T C435(0.84)  LDD1592  [10]
 LDCM0392  CL121 HEK-293T C435(0.81)  LDD0990  [11]
 LDCM0393  CL122 HEK-293T C435(0.93)  LDD0991  [11]
 LDCM0394  CL123 HEK-293T C435(2.43)  LDD0992  [11]
 LDCM0395  CL124 HEK-293T C435(0.91)  LDD0993  [11]
 LDCM0396  CL125 HEK-293T C435(0.85)  LDD0994  [11]
 LDCM0397  CL126 HEK-293T C435(1.19)  LDD0995  [11]
 LDCM0398  CL127 HEK-293T C435(1.07)  LDD0996  [11]
 LDCM0399  CL128 HEK-293T C435(1.03)  LDD0997  [11]
 LDCM0401  CL14 HEK-293T C435(1.17)  LDD1605  [10]
 LDCM0404  CL17 HEK-293T C435(0.84)  LDD1608  [10]
 LDCM0406  CL19 HEK-293T C308(1.04)  LDD1610  [10]
 LDCM0407  CL2 HEK-293T C435(0.94)  LDD1611  [10]
 LDCM0408  CL20 HEK-293T C308(1.14)  LDD1612  [10]
 LDCM0411  CL23 HEK-293T C435(1.12)  LDD1615  [10]
 LDCM0414  CL26 HEK-293T C435(0.97)  LDD1618  [10]
 LDCM0417  CL29 HEK-293T C435(0.83)  LDD1621  [10]
 LDCM0420  CL31 HEK-293T C308(1.04)  LDD1624  [10]
 LDCM0421  CL32 HEK-293T C308(1.15)  LDD1625  [10]
 LDCM0424  CL35 HEK-293T C435(1.10)  LDD1628  [10]
 LDCM0431  CL41 HEK-293T C435(0.91)  LDD1635  [10]
 LDCM0433  CL43 HEK-293T C308(0.94)  LDD1637  [10]
 LDCM0434  CL44 HEK-293T C308(1.05)  LDD1638  [10]
 LDCM0436  CL46 HEK-293T C435(1.09)  LDD1034  [11]
 LDCM0437  CL47 HEK-293T C435(0.97)  LDD1035  [11]
 LDCM0438  CL48 HEK-293T C435(0.66)  LDD1036  [11]
 LDCM0439  CL49 HEK-293T C435(0.79)  LDD1037  [11]
 LDCM0440  CL5 HEK-293T C435(1.07)  LDD1644  [10]
 LDCM0441  CL50 HEK-293T C435(1.14)  LDD1039  [11]
 LDCM0442  CL51 HEK-293T C435(1.12)  LDD1040  [11]
 LDCM0443  CL52 HEK-293T C435(0.94)  LDD1041  [11]
 LDCM0444  CL53 HEK-293T C435(1.11)  LDD1042  [11]
 LDCM0445  CL54 HEK-293T C435(1.67)  LDD1043  [11]
 LDCM0446  CL55 HEK-293T C435(0.74)  LDD1044  [11]
 LDCM0447  CL56 HEK-293T C435(0.95)  LDD1045  [11]
 LDCM0448  CL57 HEK-293T C435(1.24)  LDD1046  [11]
 LDCM0449  CL58 HEK-293T C435(1.03)  LDD1047  [11]
 LDCM0450  CL59 HEK-293T C435(1.08)  LDD1048  [11]
 LDCM0452  CL60 HEK-293T C435(0.93)  LDD1050  [11]
 LDCM0454  CL62 HEK-293T C435(1.18)  LDD1657  [10]
 LDCM0457  CL65 HEK-293T C435(0.87)  LDD1660  [10]
 LDCM0459  CL67 HEK-293T C308(1.02)  LDD1662  [10]
 LDCM0460  CL68 HEK-293T C308(1.04)  LDD1663  [10]
 LDCM0462  CL7 HEK-293T C308(0.93)  LDD1665  [10]
 LDCM0464  CL71 HEK-293T C435(1.17)  LDD1667  [10]
 LDCM0467  CL74 HEK-293T C435(0.84)  LDD1670  [10]
 LDCM0470  CL77 HEK-293T C435(0.91)  LDD1673  [10]
 LDCM0472  CL79 HEK-293T C308(1.06)  LDD1675  [10]
 LDCM0473  CL8 HEK-293T C308(0.97)  LDD1676  [10]
 LDCM0474  CL80 HEK-293T C308(1.05)  LDD1677  [10]
 LDCM0477  CL83 HEK-293T C435(1.18)  LDD1680  [10]
 LDCM0480  CL86 HEK-293T C435(0.91)  LDD1683  [10]
 LDCM0483  CL89 HEK-293T C435(1.04)  LDD1686  [10]
 LDCM0486  CL91 HEK-293T C308(1.11)  LDD1689  [10]
 LDCM0487  CL92 HEK-293T C308(1.06)  LDD1690  [10]
 LDCM0490  CL95 HEK-293T C435(1.41)  LDD1693  [10]
 LDCM0493  CL98 HEK-293T C435(0.81)  LDD1696  [10]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C308(1.77)  LDD1702  [2]
 LDCM0427  Fragment51 HEK-293T C435(0.77)  LDD1631  [10]
 LDCM0107  IAA HeLa N.A.  LDD0221  [3]
 LDCM0022  KB02 42-MG-BA C308(1.28)  LDD2244  [1]
 LDCM0023  KB03 42-MG-BA C308(1.72)  LDD2661  [1]
 LDCM0024  KB05 SKMEL24 C154(2.12)  LDD3323  [1]
 LDCM0546  Nucleophilic fragment 40 MDA-MB-231 C344(1.19)  LDD2140  [2]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Other
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Protein fem-1 homolog A (FEM1A) Fem-1 family Q9BSK4
Small ribosomal subunit protein uS12 (RPS23) Universal ribosomal protein uS12 family P62266

The Drug(s) Related To This Target

Approved
Click To Hide/Show 1 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Ascorbic Acid Small molecular drug DB00126

References

1 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
2 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
3 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
4 Targeted Proteomic Approaches for Proteome-Wide Characterizations of the AMP-Binding Capacities of Kinases. J Proteome Res. 2022 Aug 5;21(8):2063-2070. doi: 10.1021/acs.jproteome.2c00225. Epub 2022 Jul 12.
5 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
6 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
7 Design and synthesis of minimalist terminal alkyne-containing diazirine photo-crosslinkers and their incorporation into kinase inhibitors for cell- and tissue-based proteome profiling. Angew Chem Int Ed Engl. 2013 Aug 12;52(33):8551-6. doi: 10.1002/anie.201300683. Epub 2013 Jun 10.
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Mass spectrometry data entry: PXD044402
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