Details of the Target

General Information of Target

Target ID LDTP08632
Target Name Structure-specific endonuclease subunit SLX4 (SLX4)
Gene Name SLX4
Gene ID 84464
Synonyms
BTBD12; KIAA1784; KIAA1987; Structure-specific endonuclease subunit SLX4; BTB/POZ domain-containing protein 12
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MKLSVNEAQLGFYLGSLSHLSACPGIDPRSSEDQPESLKTGQMMDESDEDFKELCASFFQ
RVKKHGIKEVSGERKTQKAASNGTQIRSKLKRTKQTATKTKTLQGPAEKKPPSGSQAPRT
KKQRVTKWQASEPAHSVNGEGGVLASAPDPPVLRETAQNTQTGNQQEPSPNLSREKTREN
VPNSDSQPPPSCLTTAVPSPSKPRTAQLVLQRMQQFKRADPERLRHASEECSLEAAREEN
VPKDPQEEMMAGNVYGLGPPAPESDAAVALTLQQEFARVGASAHDDSLEEKGLFFCQICQ
KNLSAMNVTRREQHVNRCLDEAEKTLRPSVPQIPECPICGKPFLTLKSRTSHLKQCAVKM
EVGPQLLLQAVRLQTAQPEGSSSPPMFSFSDHSRGLKRRGPTSKKEPRKRRKVDEAPSED
LLVAMALSRSEMEPGAAVPALRLESAFSERIRPEAENKSRKKKPPVSPPLLLVQDSETTG
RQIEDRVALLLSEEVELSSTPPLPASRILKEGWERAGQCPPPPERKQSFLWEGSALTGAW
AMEDFYTARLVPPLVPQRPAQGLMQEPVPPLVPPEHSELSERRSPALHGTPTAGCGSRGP
SPSASQREHQALQDLVDLAREGLSASPWPGSGGLAGSEGTAGLDVVPGGLPLTGFVVPSQ
DKHPDRGGRTLLSLGLLVADFGAMVNNPHLSDVQFQTDSGEVLYAHKFVLYARCPLLIQY
VNNEGFSAVEDGVLTQRVLLGDVSTEAARTFLHYLYTADTGLPPGLSSELSSLAHRFGVS
ELVHLCEQVPIATDSEGKPWEEKEAENCESRAENFQELLRSMWADEEEEAETLLKSKDHE
EDQENVNEAEMEEIYEFAATQRKLLQEERAAGAGEDADWLEGGSPVSGQLLAGVQVQKQW
DKVEEMEPLEPGRDEAATTWEKMGQCALPPPQGQHSGARGAEAPEQEAPEEALGHSSCSS
PSRDCQAERKEGSLPHSDDAGDYEQLFSSTQGEISEPSQITSEPEEQSGAVRERGLEVSH
RLAPWQASPPHPCRFLLGPPQGGSPRGSHHTSGSSLSTPRSRGGTSQVGSPTLLSPAVPS
KQKRDRSILTLSKEPGHQKGKERRSVLECRNKGVLMFPEKSPSIDLTQSNPDHSSSRSQK
SSSKLNEEDEVILLLDSDEELELEQTKMKSISSDPLEEKKALEISPRSCELFSIIDVDAD
QEPSQSPPRSEAVLQQEDEGALPENRGSLGRRGAPWLFCDRESSPSEASTTDTSWLVPAT
PLASRSRDCSSQTQISSLRSGLAVQAVTQHTPRASVGNREGNEVAQKFSVIRPQTPPPQT
PSSCLTPVSPGTSDGRRQGHRSPSRPHPGGHPHSSPLAPHPISGDRAHFSRRFLKHSPPG
PSFLNQTPAGEVVEVGDSDDEQEVASHQANRSPPLDSDPPIPIDDCCWHMEPLSPIPIDH
WNLERTGPLSTSSPSRRMNEAADSRDCRSPGLLDTTPIRGSCTTQRKLQEKSSGAGSLGN
SRPSFLNSALWDVWDGEEQRPPETPPPAQMPSAGGAQKPEGLETPKGANRKKNLPPKVPI
TPMPQYSIMETPVLKKELDRFGVRPLPKRQMVLKLKEIFQYTHQTLDSDSEDESQSSQPL
LQAPHCQTLASQTYKPSRAGVHAQQEATTGPGAHRPKGPAKTKGPRHQRKHHESITPPSR
SPTKEAPPGLNDDAQIPASQESVATSVDGSDSSLSSQSSSSCEFGAAFESAGEEEGEGEV
SASQAAVQAADTDEALRCYIRSKPALYQKVLLYQPFELRELQAELRQNGLRVSSRRLLDF
LDTHCITFTTAATRREKLQGRRRQPRGKKKVERN
Target Bioclass
Other
Family
SLX4 family
Subcellular location
Nucleus
Function
Regulatory subunit that interacts with and increases the activity of different structure-specific endonucleases. Has several distinct roles in protecting genome stability by resolving diverse forms of deleterious DNA structures originating from replication and recombination intermediates and from DNA damage. Component of the SLX1-SLX4 structure-specific endonuclease that resolves DNA secondary structures generated during DNA repair and recombination. Has endonuclease activity towards branched DNA substrates, introducing single-strand cuts in duplex DNA close to junctions with ss-DNA. Has a preference for 5'-flap structures, and promotes symmetrical cleavage of static and migrating Holliday junctions (HJs). Resolves HJs by generating two pairs of ligatable, nicked duplex products. Interacts with the structure-specific ERCC4-ERCC1 endonuclease and promotes the cleavage of bubble structures. Interacts with the structure-specific MUS81-EME1 endonuclease and promotes the cleavage of 3'-flap and replication fork-like structures. SLX4 is required for recovery from alkylation-induced DNA damage and is involved in the resolution of DNA double-strand breaks.
Uniprot ID
Q8IY92
Ensemble ID
ENST00000294008.4
HGNC ID
HGNC:23845

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
22RV1 Insertion: p.L470IfsTer8 .
CCK81 SNV: p.P504H .
CHL1 SNV: p.L103F .
EFO27 SNV: p.P1327T DBIA    Probe Info 
HCT116 Deletion: p.A1461PfsTer2 .
HS936T Substitution: p.A1462V .
HSC3 SNV: p.R460C .
HT1197 SNV: p.D614G DBIA    Probe Info 
Ishikawa (Heraklio) 02 ER Deletion: p.P469HfsTer4 DBIA    Probe Info 
JEKO1 SNV: p.G395C .
JURKAT Deletion: p.P469HfsTer4 .
KYSE150 SNV: p.D1579E DBIA    Probe Info 
KYSE180 SNV: p.P1131S .
KYSE30 SNV: p.E868K DBIA    Probe Info 
LOXIMVI SNV: p.P1045S .
MDST8 Substitution: p.T919I .
MELHO SNV: p.Q1622Ter .
MEWO SNV: p.P1122S .
MFE319 SNV: p.E493K; p.S605N; p.T1544I .
MOLT4 SNV: p.L953F .
MV411 SNV: p.L612P .
NCIH2170 SNV: p.S498C DBIA    Probe Info 
NCIH358 SNV: p.A728S DBIA    Probe Info 
NUGC3 SNV: p.S228L .
OVK18 SNV: p.R1779W .
RL952 SNV: p.A505V DBIA    Probe Info 
SH4 SNV: p.P200L .
SUPT1 SNV: p.S1185N .
SW1573 SNV: p.E1178Q .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 4 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
IA-alkyne
 Probe Info  		C1033(9.40)  LDD1704  [1]
IPM
 Probe Info  		C1482(2.30)  LDD1701  [2]
DBIA
 Probe Info  		C808(2.20); C296(1.35); C299(1.35)  LDD0080  [3]
Phosphinate-6
 Probe Info  		C1269(0.00); C519(0.00); C318(0.00)  LDD0018  [4]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HEK-293T C1482(1.37); C519(1.06); C808(1.08)  LDD1507  [5]
 LDCM0215  AC10 PaTu 8988t C808(1.59)  LDD1094  [3]
 LDCM0216  AC100 HEK-293T C808(0.95)  LDD0814  [3]
 LDCM0217  AC101 HEK-293T C808(0.99)  LDD0815  [3]
 LDCM0218  AC102 HEK-293T C808(1.00)  LDD0816  [3]
 LDCM0219  AC103 HEK-293T C808(1.07)  LDD0817  [3]
 LDCM0220  AC104 HEK-293T C808(1.24)  LDD0818  [3]
 LDCM0221  AC105 HEK-293T C808(0.93)  LDD0819  [3]
 LDCM0222  AC106 HEK-293T C808(0.93)  LDD0820  [3]
 LDCM0223  AC107 HEK-293T C808(1.06)  LDD0821  [3]
 LDCM0224  AC108 HEK-293T C808(0.93)  LDD0822  [3]
 LDCM0225  AC109 HEK-293T C808(0.97)  LDD0823  [3]
 LDCM0226  AC11 PaTu 8988t C808(0.93)  LDD1105  [3]
 LDCM0227  AC110 HEK-293T C808(1.46)  LDD0825  [3]
 LDCM0228  AC111 HEK-293T C808(1.71)  LDD0826  [3]
 LDCM0229  AC112 HEK-293T C808(1.41)  LDD0827  [3]
 LDCM0237  AC12 PaTu 8988t C808(1.28)  LDD1116  [3]
 LDCM0246  AC128 HEK-293T C808(0.97)  LDD0844  [3]
 LDCM0247  AC129 HEK-293T C808(1.11)  LDD0845  [3]
 LDCM0249  AC130 HEK-293T C808(0.98)  LDD0847  [3]
 LDCM0250  AC131 HEK-293T C808(0.71)  LDD0848  [3]
 LDCM0251  AC132 HEK-293T C808(1.60)  LDD0849  [3]
 LDCM0252  AC133 HEK-293T C808(1.41)  LDD0850  [3]
 LDCM0253  AC134 HEK-293T C808(0.92)  LDD0851  [3]
 LDCM0254  AC135 HEK-293T C808(0.78)  LDD0852  [3]
 LDCM0255  AC136 HEK-293T C808(1.17)  LDD0853  [3]
 LDCM0256  AC137 HEK-293T C808(1.43)  LDD0854  [3]
 LDCM0257  AC138 HEK-293T C808(1.46)  LDD0855  [3]
 LDCM0258  AC139 HEK-293T C808(1.36)  LDD0856  [3]
 LDCM0259  AC14 PaTu 8988t C808(1.19)  LDD1138  [3]
 LDCM0260  AC140 HEK-293T C808(1.92)  LDD0858  [3]
 LDCM0261  AC141 HEK-293T C808(1.46)  LDD0859  [3]
 LDCM0262  AC142 HEK-293T C808(1.63)  LDD0860  [3]
 LDCM0263  AC143 HEK-293T C808(0.72)  LDD0861  [3]
 LDCM0264  AC144 HEK-293T C808(0.96)  LDD0862  [3]
 LDCM0265  AC145 HEK-293T C808(1.21)  LDD0863  [3]
 LDCM0266  AC146 HEK-293T C808(1.25)  LDD0864  [3]
 LDCM0267  AC147 HEK-293T C808(0.62)  LDD0865  [3]
 LDCM0268  AC148 HEK-293T C808(0.94)  LDD0866  [3]
 LDCM0269  AC149 HEK-293T C808(1.01)  LDD0867  [3]
 LDCM0270  AC15 PaTu 8988t C808(0.94)  LDD1149  [3]
 LDCM0271  AC150 HEK-293T C808(0.56)  LDD0869  [3]
 LDCM0272  AC151 HEK-293T C808(1.17)  LDD0870  [3]
 LDCM0273  AC152 HEK-293T C808(1.29)  LDD0871  [3]
 LDCM0274  AC153 HEK-293T C808(1.40)  LDD0872  [3]
 LDCM0621  AC154 HEK-293T C808(1.20)  LDD2162  [3]
 LDCM0622  AC155 HEK-293T C808(0.89)  LDD2163  [3]
 LDCM0623  AC156 HEK-293T C808(1.70)  LDD2164  [3]
 LDCM0624  AC157 HEK-293T C808(2.22)  LDD2165  [3]
 LDCM0276  AC17 HEK-293T C1482(1.33); C519(1.09); C808(1.00)  LDD1515  [5]
 LDCM0277  AC18 HEK-293T C1482(1.15); C519(1.31); C1805(0.99)  LDD1516  [5]
 LDCM0278  AC19 HEK-293T C1482(1.37); C519(1.12); C808(1.22)  LDD1517  [5]
 LDCM0279  AC2 HEK-293T C1482(1.05); C519(1.38); C1805(0.96)  LDD1518  [5]
 LDCM0280  AC20 HEK-293T C519(1.03); C808(0.98)  LDD1519  [5]
 LDCM0281  AC21 HEK-293T C1482(0.97); C1269(1.10)  LDD1520  [5]
 LDCM0282  AC22 HEK-293T C1482(1.00); C519(1.09)  LDD1521  [5]
 LDCM0283  AC23 HEK-293T C1482(0.94)  LDD1522  [5]
 LDCM0284  AC24 HEK-293T C1482(1.00); C519(1.26); C1805(1.01)  LDD1523  [5]
 LDCM0285  AC25 HEK-293T C1482(1.15); C519(1.11); C808(1.07)  LDD1524  [5]
 LDCM0286  AC26 HEK-293T C1482(1.19); C519(1.16); C1805(1.04)  LDD1525  [5]
 LDCM0287  AC27 HEK-293T C1482(1.00); C519(1.16); C808(1.10)  LDD1526  [5]
 LDCM0288  AC28 HEK-293T C519(1.21); C808(1.02)  LDD1527  [5]
 LDCM0289  AC29 HEK-293T C1482(0.94); C1269(1.01)  LDD1528  [5]
 LDCM0290  AC3 HEK-293T C1482(1.13); C519(1.08); C808(1.09)  LDD1529  [5]
 LDCM0291  AC30 HEK-293T C1482(0.99); C519(1.03)  LDD1530  [5]
 LDCM0292  AC31 HEK-293T C1482(0.87)  LDD1531  [5]
 LDCM0293  AC32 HEK-293T C1482(0.94); C519(1.06); C1805(0.99)  LDD1532  [5]
 LDCM0294  AC33 HEK-293T C1482(0.90); C519(1.35); C808(1.03)  LDD1533  [5]
 LDCM0295  AC34 HEK-293T C1482(1.16); C519(1.37); C1805(1.16)  LDD1534  [5]
 LDCM0296  AC35 HEK-293T C1482(1.07); C519(1.29); C808(1.00)  LDD1535  [5]
 LDCM0297  AC36 HEK-293T C519(1.08); C808(0.96)  LDD1536  [5]
 LDCM0298  AC37 HEK-293T C1482(1.01); C1269(1.12)  LDD1537  [5]
 LDCM0299  AC38 HEK-293T C1482(1.04); C519(1.14)  LDD1538  [5]
 LDCM0300  AC39 HEK-293T C1482(1.07)  LDD1539  [5]
 LDCM0301  AC4 HEK-293T C519(1.29); C808(0.81)  LDD1540  [5]
 LDCM0302  AC40 HEK-293T C1482(1.01); C519(1.37); C1805(1.01)  LDD1541  [5]
 LDCM0303  AC41 HEK-293T C1482(1.27); C519(0.80); C808(1.14)  LDD1542  [5]
 LDCM0304  AC42 HEK-293T C1482(1.21); C519(0.87); C1805(1.07)  LDD1543  [5]
 LDCM0305  AC43 HEK-293T C1482(1.07); C519(0.67); C808(0.93)  LDD1544  [5]
 LDCM0306  AC44 HEK-293T C519(0.66); C808(1.08)  LDD1545  [5]
 LDCM0307  AC45 HEK-293T C1482(1.00); C1269(1.12)  LDD1546  [5]
 LDCM0308  AC46 HEK-293T C1482(1.13); C519(0.71)  LDD1547  [5]
 LDCM0309  AC47 HEK-293T C1482(1.09)  LDD1548  [5]
 LDCM0310  AC48 HEK-293T C1482(1.03); C519(0.49); C1805(0.98)  LDD1549  [5]
 LDCM0311  AC49 HEK-293T C1482(0.81); C519(0.78); C808(0.97)  LDD1550  [5]
 LDCM0312  AC5 HEK-293T C1482(0.88); C1269(1.06)  LDD1551  [5]
 LDCM0313  AC50 HEK-293T C1482(1.03); C519(0.77); C1805(1.06)  LDD1552  [5]
 LDCM0314  AC51 HEK-293T C1482(1.13); C519(0.64); C808(0.97)  LDD1553  [5]
 LDCM0315  AC52 HEK-293T C519(0.70); C808(1.00)  LDD1554  [5]
 LDCM0316  AC53 HEK-293T C1482(0.88); C1269(1.06)  LDD1555  [5]
 LDCM0317  AC54 HEK-293T C1482(1.07); C519(0.82)  LDD1556  [5]
 LDCM0318  AC55 HEK-293T C1482(0.92)  LDD1557  [5]
 LDCM0319  AC56 HEK-293T C1482(1.03); C519(0.51); C1805(1.00)  LDD1558  [5]
 LDCM0320  AC57 HEK-293T C808(0.92)  LDD0918  [3]
 LDCM0321  AC58 HEK-293T C808(1.08)  LDD0919  [3]
 LDCM0322  AC59 HEK-293T C808(0.80)  LDD0920  [3]
 LDCM0323  AC6 PaTu 8988t C808(1.31)  LDD1202  [3]
 LDCM0324  AC60 HEK-293T C808(1.23)  LDD0922  [3]
 LDCM0325  AC61 HEK-293T C808(0.69)  LDD0923  [3]
 LDCM0326  AC62 HEK-293T C808(0.87)  LDD0924  [3]
 LDCM0327  AC63 HEK-293T C808(0.74)  LDD0925  [3]
 LDCM0328  AC64 HEK-293T C808(0.90)  LDD0926  [3]
 LDCM0329  AC65 HEK-293T C808(0.94)  LDD0927  [3]
 LDCM0330  AC66 HEK-293T C808(0.96)  LDD0928  [3]
 LDCM0331  AC67 HEK-293T C808(0.90)  LDD0929  [3]
 LDCM0332  AC68 HEK-293T C808(0.79)  LDD0930  [3]
 LDCM0333  AC69 HEK-293T C808(0.64)  LDD0931  [3]
 LDCM0334  AC7 PaTu 8988t C808(0.99)  LDD1213  [3]
 LDCM0335  AC70 HEK-293T C808(0.92)  LDD0933  [3]
 LDCM0336  AC71 HEK-293T C808(0.91)  LDD0934  [3]
 LDCM0337  AC72 HEK-293T C808(1.05)  LDD0935  [3]
 LDCM0338  AC73 HEK-293T C808(0.59)  LDD0936  [3]
 LDCM0339  AC74 HEK-293T C808(0.84)  LDD0937  [3]
 LDCM0340  AC75 HEK-293T C808(0.60)  LDD0938  [3]
 LDCM0341  AC76 HEK-293T C808(0.82)  LDD0939  [3]
 LDCM0342  AC77 HEK-293T C808(0.85)  LDD0940  [3]
 LDCM0343  AC78 HEK-293T C808(1.14)  LDD0941  [3]
 LDCM0344  AC79 HEK-293T C808(0.86)  LDD0942  [3]
 LDCM0345  AC8 PaTu 8988t C808(0.98)  LDD1224  [3]
 LDCM0346  AC80 HEK-293T C808(0.96)  LDD0944  [3]
 LDCM0347  AC81 HEK-293T C808(0.67)  LDD0945  [3]
 LDCM0348  AC82 HEK-293T C808(1.00)  LDD0946  [3]
 LDCM0349  AC83 HEK-293T C808(0.98)  LDD0947  [3]
 LDCM0350  AC84 HEK-293T C808(1.03)  LDD0948  [3]
 LDCM0351  AC85 HEK-293T C808(0.94)  LDD0949  [3]
 LDCM0352  AC86 HEK-293T C808(1.06)  LDD0950  [3]
 LDCM0353  AC87 HEK-293T C808(1.07)  LDD0951  [3]
 LDCM0354  AC88 HEK-293T C808(1.01)  LDD0952  [3]
 LDCM0355  AC89 HEK-293T C808(1.03)  LDD0953  [3]
 LDCM0357  AC90 HEK-293T C808(1.07)  LDD0955  [3]
 LDCM0358  AC91 HEK-293T C808(0.98)  LDD0956  [3]
 LDCM0359  AC92 HEK-293T C808(1.05)  LDD0957  [3]
 LDCM0360  AC93 HEK-293T C808(1.25)  LDD0958  [3]
 LDCM0361  AC94 HEK-293T C808(1.13)  LDD0959  [3]
 LDCM0362  AC95 HEK-293T C808(1.06)  LDD0960  [3]
 LDCM0363  AC96 HEK-293T C808(1.05)  LDD0961  [3]
 LDCM0364  AC97 HEK-293T C808(1.58)  LDD0962  [3]
 LDCM0365  AC98 HEK-293T C808(0.98)  LDD0963  [3]
 LDCM0366  AC99 HEK-293T C808(0.89)  LDD0964  [3]
 LDCM0248  AKOS034007472 PaTu 8988t C808(2.27)  LDD1127  [3]
 LDCM0356  AKOS034007680 PaTu 8988t C808(0.99)  LDD1235  [3]
 LDCM0275  AKOS034007705 PaTu 8988t C808(0.45)  LDD1154  [3]
 LDCM0367  CL1 HEK-293T C808(1.01)  LDD0965  [3]
 LDCM0368  CL10 HEK-293T C808(1.30)  LDD0966  [3]
 LDCM0369  CL100 HEK-293T C1482(0.95); C519(1.19); C808(1.00); C1805(1.18)  LDD1573  [5]
 LDCM0370  CL101 PaTu 8988t C808(1.27)  LDD1249  [3]
 LDCM0371  CL102 PaTu 8988t C808(0.83)  LDD1250  [3]
 LDCM0372  CL103 PaTu 8988t C808(1.74)  LDD1251  [3]
 LDCM0373  CL104 PaTu 8988t C808(1.14)  LDD1252  [3]
 LDCM0374  CL105 HEK-293T C1482(1.02)  LDD1578  [5]
 LDCM0375  CL106 HEK-293T C1482(0.98)  LDD1579  [5]
 LDCM0376  CL107 HEK-293T C519(1.21)  LDD1580  [5]
 LDCM0377  CL108 HEK-293T C1482(1.06); C519(1.13); C808(0.85); C1805(1.27)  LDD1581  [5]
 LDCM0378  CL109 HEK-293T C1482(1.01)  LDD1582  [5]
 LDCM0379  CL11 HEK-293T C808(1.24)  LDD0977  [3]
 LDCM0380  CL110 HEK-293T C1482(1.13)  LDD1584  [5]
 LDCM0381  CL111 HEK-293T C519(1.47)  LDD1585  [5]
 LDCM0382  CL112 HEK-293T C1482(1.13); C519(1.42); C808(0.96); C1805(1.12)  LDD1586  [5]
 LDCM0383  CL113 HEK-293T C1482(1.07)  LDD1587  [5]
 LDCM0384  CL114 HEK-293T C1482(1.15)  LDD1588  [5]
 LDCM0385  CL115 HEK-293T C519(1.99)  LDD1589  [5]
 LDCM0386  CL116 HEK-293T C1482(1.05); C519(1.39); C808(1.06); C1805(0.98)  LDD1590  [5]
 LDCM0387  CL117 HEK-293T C1482(1.15)  LDD1591  [5]
 LDCM0388  CL118 HEK-293T C1482(1.14)  LDD1592  [5]
 LDCM0389  CL119 HEK-293T C519(0.55)  LDD1593  [5]
 LDCM0390  CL12 HEK-293T C808(0.95)  LDD0988  [3]
 LDCM0391  CL120 HEK-293T C1482(1.03); C519(0.70); C808(1.07); C1805(1.22)  LDD1595  [5]
 LDCM0392  CL121 HEK-293T C1482(1.00)  LDD1596  [5]
 LDCM0393  CL122 HEK-293T C1482(0.96)  LDD1597  [5]
 LDCM0394  CL123 HEK-293T C519(0.56)  LDD1598  [5]
 LDCM0395  CL124 HEK-293T C1482(0.94); C519(0.68); C808(0.92); C1805(0.94)  LDD1599  [5]
 LDCM0396  CL125 HEK-293T C808(0.86)  LDD0994  [3]
 LDCM0397  CL126 HEK-293T C808(1.37)  LDD0995  [3]
 LDCM0398  CL127 HEK-293T C808(0.79)  LDD0996  [3]
 LDCM0399  CL128 HEK-293T C808(1.45)  LDD0997  [3]
 LDCM0400  CL13 HEK-293T C808(0.93)  LDD0998  [3]
 LDCM0401  CL14 HEK-293T C808(1.04)  LDD0999  [3]
 LDCM0402  CL15 HEK-293T C808(1.07)  LDD1000  [3]
 LDCM0403  CL16 HEK-293T C1482(1.05); C519(1.40); C808(1.03); C1805(0.99)  LDD1607  [5]
 LDCM0404  CL17 HEK-293T C1482(1.07); C519(1.23); C808(1.04)  LDD1608  [5]
 LDCM0405  CL18 HEK-293T C1482(1.05); C519(1.33); C1805(1.12)  LDD1609  [5]
 LDCM0406  CL19 HEK-293T C1482(1.02); C519(1.23); C808(1.08)  LDD1610  [5]
 LDCM0407  CL2 HEK-293T C808(0.92)  LDD1005  [3]
 LDCM0408  CL20 HEK-293T C519(1.44); C808(0.97)  LDD1612  [5]
 LDCM0409  CL21 HEK-293T C1482(1.04); C1269(1.01)  LDD1613  [5]
 LDCM0410  CL22 HEK-293T C1482(1.01); C519(1.34)  LDD1614  [5]
 LDCM0411  CL23 HEK-293T C1482(0.83)  LDD1615  [5]
 LDCM0412  CL24 HEK-293T C1482(0.95); C519(1.81); C1805(0.93)  LDD1616  [5]
 LDCM0413  CL25 HEK-293T C1482(0.99)  LDD1617  [5]
 LDCM0414  CL26 HEK-293T C1482(0.99)  LDD1618  [5]
 LDCM0415  CL27 HEK-293T C519(1.97)  LDD1619  [5]
 LDCM0416  CL28 HEK-293T C1482(1.03); C519(1.35); C808(0.86); C1805(1.36)  LDD1620  [5]
 LDCM0417  CL29 HEK-293T C1482(1.18); C519(1.23); C808(0.97)  LDD1621  [5]
 LDCM0418  CL3 HEK-293T C808(0.86)  LDD1016  [3]
 LDCM0419  CL30 HEK-293T C1482(1.03); C519(1.05); C1805(1.00)  LDD1623  [5]
 LDCM0420  CL31 HEK-293T C808(0.97)  LDD1018  [3]
 LDCM0421  CL32 HEK-293T C808(0.90)  LDD1019  [3]
 LDCM0422  CL33 HEK-293T C808(0.91)  LDD1020  [3]
 LDCM0423  CL34 HEK-293T C808(0.97)  LDD1021  [3]
 LDCM0424  CL35 HEK-293T C808(0.82)  LDD1022  [3]
 LDCM0425  CL36 HEK-293T C808(0.96)  LDD1023  [3]
 LDCM0426  CL37 HEK-293T C808(0.96)  LDD1024  [3]
 LDCM0428  CL39 HEK-293T C808(1.27)  LDD1026  [3]
 LDCM0429  CL4 HEK-293T C808(1.01)  LDD1027  [3]
 LDCM0430  CL40 HEK-293T C808(1.02)  LDD1028  [3]
 LDCM0431  CL41 HEK-293T C808(1.15)  LDD1029  [3]
 LDCM0432  CL42 HEK-293T C808(1.04)  LDD1030  [3]
 LDCM0433  CL43 HEK-293T C808(1.09)  LDD1031  [3]
 LDCM0434  CL44 HEK-293T C808(0.83)  LDD1032  [3]
 LDCM0435  CL45 HEK-293T C808(1.05)  LDD1033  [3]
 LDCM0436  CL46 HEK-293T C808(1.00)  LDD1034  [3]
 LDCM0437  CL47 HEK-293T C808(0.99)  LDD1035  [3]
 LDCM0438  CL48 HEK-293T C808(0.93)  LDD1036  [3]
 LDCM0439  CL49 HEK-293T C808(1.16)  LDD1037  [3]
 LDCM0440  CL5 HEK-293T C808(1.05)  LDD1038  [3]
 LDCM0441  CL50 HEK-293T C808(1.50)  LDD1039  [3]
 LDCM0442  CL51 HEK-293T C808(1.30)  LDD1040  [3]
 LDCM0443  CL52 HEK-293T C808(0.93)  LDD1041  [3]
 LDCM0444  CL53 HEK-293T C808(1.16)  LDD1042  [3]
 LDCM0445  CL54 HEK-293T C808(1.28)  LDD1043  [3]
 LDCM0446  CL55 HEK-293T C808(1.10)  LDD1044  [3]
 LDCM0447  CL56 HEK-293T C808(1.00)  LDD1045  [3]
 LDCM0448  CL57 HEK-293T C808(1.34)  LDD1046  [3]
 LDCM0449  CL58 HEK-293T C808(1.19)  LDD1047  [3]
 LDCM0450  CL59 HEK-293T C808(1.13)  LDD1048  [3]
 LDCM0451  CL6 HEK-293T C808(0.99)  LDD1049  [3]
 LDCM0452  CL60 HEK-293T C808(1.28)  LDD1050  [3]
 LDCM0453  CL61 HEK-293T C808(0.73)  LDD1051  [3]
 LDCM0454  CL62 HEK-293T C808(0.76)  LDD1052  [3]
 LDCM0455  CL63 HEK-293T C808(0.84)  LDD1053  [3]
 LDCM0456  CL64 HEK-293T C808(0.89)  LDD1054  [3]
 LDCM0457  CL65 HEK-293T C808(0.80)  LDD1055  [3]
 LDCM0458  CL66 HEK-293T C808(0.82)  LDD1056  [3]
 LDCM0459  CL67 HEK-293T C808(0.87)  LDD1057  [3]
 LDCM0460  CL68 HEK-293T C808(0.91)  LDD1058  [3]
 LDCM0461  CL69 HEK-293T C808(0.90)  LDD1059  [3]
 LDCM0462  CL7 HEK-293T C808(0.99)  LDD1060  [3]
 LDCM0463  CL70 HEK-293T C808(0.97)  LDD1061  [3]
 LDCM0464  CL71 HEK-293T C808(0.91)  LDD1062  [3]
 LDCM0465  CL72 HEK-293T C808(0.79)  LDD1063  [3]
 LDCM0466  CL73 HEK-293T C808(1.14)  LDD1064  [3]
 LDCM0467  CL74 HEK-293T C808(1.01)  LDD1065  [3]
 LDCM0469  CL76 HEK-293T C808(0.93)  LDD1067  [3]
 LDCM0470  CL77 HEK-293T C808(1.11)  LDD1068  [3]
 LDCM0471  CL78 HEK-293T C808(0.63)  LDD1069  [3]
 LDCM0472  CL79 HEK-293T C808(0.80)  LDD1070  [3]
 LDCM0473  CL8 HEK-293T C808(1.18)  LDD1071  [3]
 LDCM0474  CL80 HEK-293T C808(0.94)  LDD1072  [3]
 LDCM0475  CL81 HEK-293T C808(0.77)  LDD1073  [3]
 LDCM0476  CL82 HEK-293T C808(1.00)  LDD1074  [3]
 LDCM0477  CL83 HEK-293T C808(1.22)  LDD1075  [3]
 LDCM0478  CL84 HEK-293T C808(0.83)  LDD1076  [3]
 LDCM0479  CL85 HEK-293T C808(0.70)  LDD1077  [3]
 LDCM0480  CL86 HEK-293T C808(0.64)  LDD1078  [3]
 LDCM0481  CL87 HEK-293T C808(0.91)  LDD1079  [3]
 LDCM0482  CL88 HEK-293T C808(0.91)  LDD1080  [3]
 LDCM0483  CL89 HEK-293T C808(0.80)  LDD1081  [3]
 LDCM0484  CL9 HEK-293T C808(1.34)  LDD1082  [3]
 LDCM0485  CL90 HEK-293T C808(1.01)  LDD1083  [3]
 LDCM0486  CL91 HEK-293T C1482(1.01); C519(1.10); C808(1.12)  LDD1689  [5]
 LDCM0487  CL92 HEK-293T C519(1.34); C808(0.85)  LDD1690  [5]
 LDCM0488  CL93 HEK-293T C1482(0.95); C1269(1.18)  LDD1691  [5]
 LDCM0489  CL94 HEK-293T C1482(1.06); C519(1.34)  LDD1692  [5]
 LDCM0490  CL95 HEK-293T C1482(0.80)  LDD1693  [5]
 LDCM0491  CL96 HEK-293T C1482(1.07); C519(1.55); C1805(1.05)  LDD1694  [5]
 LDCM0492  CL97 HEK-293T C1482(1.15)  LDD1695  [5]
 LDCM0493  CL98 HEK-293T C1482(0.99)  LDD1696  [5]
 LDCM0494  CL99 HEK-293T C519(1.10)  LDD1697  [5]
 LDCM0495  E2913 HEK-293T C519(1.90)  LDD1698  [5]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C318(0.44)  LDD1702  [2]
 LDCM0468  Fragment33 HEK-293T C808(1.02)  LDD1066  [3]
 LDCM0427  Fragment51 HEK-293T C808(0.83)  LDD1025  [3]
 LDCM0022  KB02 HCT 116 C808(2.20); C296(1.35); C299(1.35)  LDD0080  [3]
 LDCM0023  KB03 HCT 116 C808(1.91); C296(1.77); C299(1.77)  LDD0081  [3]
 LDCM0024  KB05 HCT 116 C808(2.12); C296(1.34); C299(1.34)  LDD0082  [3]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 6 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Crossover junction endonuclease EME1 (EME1) EME1/MMS4 family Q96AY2
DNA excision repair protein ERCC-1 (ERCC1) ERCC1/RAD10/SWI10 family P07992
Serine/threonine-protein kinase PLK1 (PLK1) Ser/Thr protein kinase family P53350
Structure-specific endonuclease subunit SLX1 (SLX1A; SLX1B) SLX1 family Q9BQ83
Crossover junction endonuclease MUS81 (MUS81) XPF family Q96NY9
DNA repair endonuclease XPF (ERCC4) XPF family Q92889
Transcription factor
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Telomeric repeat-binding factor 2-interacting protein 1 (TERF2IP) RAP1 family Q9NYB0
Other
Click To Hide/Show 3 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
DNA mismatch repair protein Msh2 (MSH2) DNA mismatch repair MutS family P43246
Protein SLX4IP (SLX4IP) SLX4IP family Q5VYV7
Telomeric repeat-binding factor 2 (TERF2) . Q15554

References

1 An Activity-Guided Map of Electrophile-Cysteine Interactions in Primary Human T Cells. Cell. 2020 Aug 20;182(4):1009-1026.e29. doi: 10.1016/j.cell.2020.07.001. Epub 2020 Jul 29.
2 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
3 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
4 DFT-Guided Discovery of Ethynyl-Triazolyl-Phosphinates as Modular Electrophiles for Chemoselective Cysteine Bioconjugation and Profiling. Angew Chem Int Ed Engl. 2022 Oct 10;61(41):e202205348. doi: 10.1002/anie.202205348. Epub 2022 Aug 22.
Mass spectrometry data entry: PXD033004
5 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402