Details of the Target

General Information of Target

Target ID LDTP08494
Target Name Formin-like protein 3 (FMNL3)
Gene Name FMNL3
Gene ID 91010
Synonyms
FHOD3; FRL2; KIAA2014; WBP3; Formin-like protein 3; Formin homology 2 domain-containing protein 3; WW domain-binding protein 3; WBP-3
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MGNLESAEGVPGEPPSVPLLLPPGKMPMPEPCELEERFALVLSSMNLPPDKARLLRQYDN
EKKWDLICDQERFQVKNPPHTYIQKLQSFLDPSVTRKKFRRRVQESTKVLRELEISLRTN
HIGWVREFLNDENKGLDVLVDYLSFAQCSVMFDFEGLESGDDGAFDKLRSWSRSIEDLQP
PSALSAPFTNSLARSARQSVLRYSTLPGRRALKNSRLVSQKDDVHVCILCLRAIMNYQYG
FNLVMSHPHAVNEIALSLNNKNPRTKALVLELLAAVCLVRGGHEIILAAFDNFKEVCKEL
HRFEKLMEYFRNEDSNIDFMVACMQFINIVVHSVEDMNFRVHLQYEFTKLGLEEFLQKSR
HTESEKLQVQIQAYLDNVFDVGGLLEDAETKNVALEKVEELEEHVSHLTEKLLDLENENM
MRVAELEKQLLQREKELESIKETYENTSHQVHTLRRLIKEKEEAFQRRCHLEPNVRGLES
VDSEALARVGPAELSEGMPPSDLDLLAPAPPPEEVLPLPPPPAPPLPPPPPPLPDKCPPA
PPLPGAAPSVVLTVGLSAIRIKKPIKTKFRLPVFNWTALKPNQISGTVFSELDDEKILED
LDLDKFEELFKTKAQGPALDLICSKNKTAQKAASKVTLLEANRAKNLAITLRKAGRSAEE
ICRAIHTFDLQTLPVDFVECLMRFLPTEAEVKLLRQYERERQPLEELAAEDRFMLLFSKV
ERLTQRMAGMAFLGNFQDNLQMLTPQLNAIIAASASVKSSQKLKQMLEIILALGNYMNSS
KRGAVYGFKLQSLDLLLDTKSTDRKMTLLHFIALTVKEKYPDLANFWHELHFVEKAAAVS
LENVLLDVKELGRGMELIRRECSIHDNSVLRNFLSTNEGKLDKLQRDAKTAEEAYNAVVR
YFGESPKTTPPSVFFPVFVRFIRSYKEAEQENEARKKQEEVMREKQLAQEAKKLDAKTPS
QRNKWQQQELIAELRRRQAKEHRPVYEGKDGTIEDIITVLKSVPFTARTAKRGSRFFCDA
AHHDESNC
Target Bioclass
Other
Family
Formin homology family
Subcellular location
Cytoplasm
Function
Plays a role in the regulation of cell morphology and cytoskeletal organization. Required in the control of cell shape and migration. Required for developmental angiogenesis. In this process, required for microtubule reorganization and for efficient endothelial cell elongation. In quiescent endothelial cells, triggers rearrangement of the actin cytoskeleton, but does not alter microtubule alignement.
Uniprot ID
Q8IVF7
Ensemble ID
ENST00000335154.10
HGNC ID
HGNC:23698

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 7 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		11.73  LDD0403  [1]
DBIA
 Probe Info  		C735(2.54)  LDD3319  [2]
AHL-Pu-1
 Probe Info  		C680(2.03)  LDD0168  [3]
IA-alkyne
 Probe Info  		C680(0.00); C662(0.00)  LDD0165  [4]
NAIA_4
 Probe Info  		N.A.  LDD2226  [5]
IPM
 Probe Info  		N.A.  LDD0005  [6]
TFBX
 Probe Info  		C623(0.00); C662(0.00)  LDD0148  [7]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0025  4SU-RNA HEK-293T C680(2.03)  LDD0168  [3]
 LDCM0026  4SU-RNA+native RNA HEK-293T C680(3.74)  LDD0169  [3]
 LDCM0214  AC1 PaTu 8988t C1018(1.52); C1028(1.52)  LDD1093  [8]
 LDCM0215  AC10 PaTu 8988t C1018(1.23); C1028(1.23)  LDD1094  [8]
 LDCM0216  AC100 PaTu 8988t C1018(1.71); C1028(1.71)  LDD1095  [8]
 LDCM0217  AC101 PaTu 8988t C1018(1.90); C1028(1.90)  LDD1096  [8]
 LDCM0218  AC102 PaTu 8988t C1018(1.24); C1028(1.24)  LDD1097  [8]
 LDCM0219  AC103 PaTu 8988t C1018(1.30); C1028(1.30)  LDD1098  [8]
 LDCM0220  AC104 PaTu 8988t C1018(2.26); C1028(2.26)  LDD1099  [8]
 LDCM0221  AC105 PaTu 8988t C1018(2.00); C1028(2.00)  LDD1100  [8]
 LDCM0222  AC106 PaTu 8988t C1018(1.67); C1028(1.67)  LDD1101  [8]
 LDCM0223  AC107 PaTu 8988t C1018(1.39); C1028(1.39)  LDD1102  [8]
 LDCM0224  AC108 PaTu 8988t C1018(1.71); C1028(1.71)  LDD1103  [8]
 LDCM0225  AC109 PaTu 8988t C1018(2.36); C1028(2.36)  LDD1104  [8]
 LDCM0226  AC11 PaTu 8988t C1018(1.44); C1028(1.44)  LDD1105  [8]
 LDCM0227  AC110 PaTu 8988t C1018(1.66); C1028(1.66)  LDD1106  [8]
 LDCM0228  AC111 PaTu 8988t C1018(2.05); C1028(2.05)  LDD1107  [8]
 LDCM0229  AC112 PaTu 8988t C1018(1.91); C1028(1.91)  LDD1108  [8]
 LDCM0230  AC113 PaTu 8988t C1018(0.59); C1028(0.59)  LDD1109  [8]
 LDCM0231  AC114 PaTu 8988t C1018(0.62); C1028(0.62)  LDD1110  [8]
 LDCM0232  AC115 PaTu 8988t C1018(0.62); C1028(0.62)  LDD1111  [8]
 LDCM0233  AC116 PaTu 8988t C1018(1.14); C1028(1.14)  LDD1112  [8]
 LDCM0234  AC117 PaTu 8988t C1018(0.65); C1028(0.65)  LDD1113  [8]
 LDCM0235  AC118 PaTu 8988t C1018(0.67); C1028(0.67)  LDD1114  [8]
 LDCM0236  AC119 PaTu 8988t C1018(0.78); C1028(0.78)  LDD1115  [8]
 LDCM0237  AC12 PaTu 8988t C1018(1.06); C1028(1.06)  LDD1116  [8]
 LDCM0238  AC120 PaTu 8988t C1018(0.65); C1028(0.65)  LDD1117  [8]
 LDCM0239  AC121 PaTu 8988t C1018(0.67); C1028(0.67)  LDD1118  [8]
 LDCM0240  AC122 PaTu 8988t C1018(0.67); C1028(0.67)  LDD1119  [8]
 LDCM0241  AC123 PaTu 8988t C1018(0.78); C1028(0.78)  LDD1120  [8]
 LDCM0242  AC124 PaTu 8988t C1018(0.72); C1028(0.72)  LDD1121  [8]
 LDCM0243  AC125 PaTu 8988t C1018(0.72); C1028(0.72)  LDD1122  [8]
 LDCM0244  AC126 PaTu 8988t C1018(0.65); C1028(0.65)  LDD1123  [8]
 LDCM0245  AC127 PaTu 8988t C1018(0.63); C1028(0.63)  LDD1124  [8]
 LDCM0246  AC128 PaTu 8988t C1018(1.22); C1028(1.22)  LDD1125  [8]
 LDCM0247  AC129 PaTu 8988t C1018(1.17); C1028(1.17)  LDD1126  [8]
 LDCM0249  AC130 PaTu 8988t C1018(1.33); C1028(1.33)  LDD1128  [8]
 LDCM0250  AC131 PaTu 8988t C1018(1.13); C1028(1.13)  LDD1129  [8]
 LDCM0251  AC132 PaTu 8988t C1018(0.94); C1028(0.94)  LDD1130  [8]
 LDCM0252  AC133 PaTu 8988t C1018(0.99); C1028(0.99)  LDD1131  [8]
 LDCM0253  AC134 PaTu 8988t C1018(1.27); C1028(1.27)  LDD1132  [8]
 LDCM0254  AC135 PaTu 8988t C1018(1.11); C1028(1.11)  LDD1133  [8]
 LDCM0255  AC136 PaTu 8988t C1018(1.20); C1028(1.20)  LDD1134  [8]
 LDCM0256  AC137 PaTu 8988t C1018(1.18); C1028(1.18)  LDD1135  [8]
 LDCM0257  AC138 PaTu 8988t C1018(1.07); C1028(1.07)  LDD1136  [8]
 LDCM0258  AC139 PaTu 8988t C1018(1.02); C1028(1.02)  LDD1137  [8]
 LDCM0259  AC14 PaTu 8988t C1018(1.40); C1028(1.40)  LDD1138  [8]
 LDCM0260  AC140 PaTu 8988t C1018(1.20); C1028(1.20)  LDD1139  [8]
 LDCM0261  AC141 PaTu 8988t C1018(1.19); C1028(1.19)  LDD1140  [8]
 LDCM0262  AC142 PaTu 8988t C1018(1.05); C1028(1.05)  LDD1141  [8]
 LDCM0270  AC15 PaTu 8988t C1018(1.43); C1028(1.43)  LDD1149  [8]
 LDCM0276  AC17 PaTu 8988t C1018(1.01); C1028(1.01)  LDD1155  [8]
 LDCM0277  AC18 PaTu 8988t C1018(1.25); C1028(1.25)  LDD1156  [8]
 LDCM0278  AC19 PaTu 8988t C1018(1.01); C1028(1.01)  LDD1157  [8]
 LDCM0279  AC2 PaTu 8988t C1018(1.55); C1028(1.55)  LDD1158  [8]
 LDCM0280  AC20 PaTu 8988t C1018(1.10); C1028(1.10)  LDD1159  [8]
 LDCM0281  AC21 PaTu 8988t C1018(1.15); C1028(1.15)  LDD1160  [8]
 LDCM0282  AC22 PaTu 8988t C1018(1.01); C1028(1.01)  LDD1161  [8]
 LDCM0283  AC23 PaTu 8988t C1018(1.36); C1028(1.36)  LDD1162  [8]
 LDCM0284  AC24 PaTu 8988t C1018(1.30); C1028(1.30)  LDD1163  [8]
 LDCM0285  AC25 PaTu 8988t C469(1.41)  LDD1164  [8]
 LDCM0286  AC26 PaTu 8988t C469(1.16)  LDD1165  [8]
 LDCM0287  AC27 PaTu 8988t C469(1.15)  LDD1166  [8]
 LDCM0288  AC28 PaTu 8988t C469(1.65)  LDD1167  [8]
 LDCM0289  AC29 PaTu 8988t C469(0.98)  LDD1168  [8]
 LDCM0290  AC3 PaTu 8988t C1018(1.24); C1028(1.24)  LDD1169  [8]
 LDCM0291  AC30 PaTu 8988t C469(0.80)  LDD1170  [8]
 LDCM0292  AC31 PaTu 8988t C469(1.32)  LDD1171  [8]
 LDCM0293  AC32 PaTu 8988t C469(0.92)  LDD1172  [8]
 LDCM0294  AC33 PaTu 8988t C469(0.63)  LDD1173  [8]
 LDCM0295  AC34 PaTu 8988t C469(0.45)  LDD1174  [8]
 LDCM0296  AC35 PaTu 8988t C1018(1.20); C1028(1.20)  LDD1175  [8]
 LDCM0297  AC36 PaTu 8988t C1018(1.30); C1028(1.30)  LDD1176  [8]
 LDCM0298  AC37 PaTu 8988t C1018(1.20); C1028(1.20)  LDD1177  [8]
 LDCM0299  AC38 PaTu 8988t C1018(1.49); C1028(1.49)  LDD1178  [8]
 LDCM0300  AC39 PaTu 8988t C1018(1.24); C1028(1.24)  LDD1179  [8]
 LDCM0301  AC4 PaTu 8988t C1018(1.34); C1028(1.34)  LDD1180  [8]
 LDCM0302  AC40 PaTu 8988t C1018(1.60); C1028(1.60)  LDD1181  [8]
 LDCM0303  AC41 PaTu 8988t C1018(1.27); C1028(1.27)  LDD1182  [8]
 LDCM0304  AC42 PaTu 8988t C1018(1.38); C1028(1.38)  LDD1183  [8]
 LDCM0305  AC43 PaTu 8988t C1018(1.07); C1028(1.07)  LDD1184  [8]
 LDCM0306  AC44 PaTu 8988t C1018(1.46); C1028(1.46)  LDD1185  [8]
 LDCM0307  AC45 PaTu 8988t C1018(1.06); C1028(1.06)  LDD1186  [8]
 LDCM0308  AC46 PaTu 8988t C469(1.21); C1018(0.92); C1028(0.92)  LDD1187  [8]
 LDCM0309  AC47 PaTu 8988t C469(1.10); C1018(0.98); C1028(0.98)  LDD1188  [8]
 LDCM0310  AC48 PaTu 8988t C469(1.54); C1018(1.33); C1028(1.33)  LDD1189  [8]
 LDCM0311  AC49 PaTu 8988t C469(1.08); C1018(1.02); C1028(1.02)  LDD1190  [8]
 LDCM0312  AC5 PaTu 8988t C1018(1.45); C1028(1.45)  LDD1191  [8]
 LDCM0313  AC50 PaTu 8988t C469(1.14); C1018(1.23); C1028(1.23)  LDD1192  [8]
 LDCM0314  AC51 PaTu 8988t C469(0.80); C1018(0.26); C1028(0.26)  LDD1193  [8]
 LDCM0315  AC52 PaTu 8988t C469(0.94); C1018(0.92); C1028(0.92)  LDD1194  [8]
 LDCM0316  AC53 PaTu 8988t C469(1.28); C1018(1.18); C1028(1.18)  LDD1195  [8]
 LDCM0317  AC54 PaTu 8988t C469(1.13); C1018(1.10); C1028(1.10)  LDD1196  [8]
 LDCM0318  AC55 PaTu 8988t C469(0.98); C1018(0.71); C1028(0.71)  LDD1197  [8]
 LDCM0319  AC56 PaTu 8988t C469(0.98); C1018(1.05); C1028(1.05)  LDD1198  [8]
 LDCM0320  AC57 HEK-293T C537(1.04); C680(1.03); C623(0.85)  LDD1559  [9]
 LDCM0321  AC58 HEK-293T C537(0.89); C680(0.89); C623(1.00)  LDD1560  [9]
 LDCM0322  AC59 HEK-293T C537(0.95); C680(1.10)  LDD1561  [9]
 LDCM0323  AC6 PaTu 8988t C1018(1.13); C1028(1.13)  LDD1202  [8]
 LDCM0324  AC60 HEK-293T C537(0.86); C680(1.06); C623(0.83)  LDD1563  [9]
 LDCM0325  AC61 HEK-293T C537(1.19); C680(1.04); C623(1.05)  LDD1564  [9]
 LDCM0326  AC62 HEK-293T C537(1.14); C680(1.18); C623(1.01)  LDD1565  [9]
 LDCM0327  AC63 HEK-293T C680(1.11); C623(0.94)  LDD1566  [9]
 LDCM0328  AC64 HEK-293T C537(1.14); C680(1.11); C623(1.02)  LDD1567  [9]
 LDCM0332  AC68 PaTu 8988t C469(0.98); C1018(1.15); C1028(1.15)  LDD1211  [8]
 LDCM0333  AC69 PaTu 8988t C469(1.25); C1018(1.20); C1028(1.20)  LDD1212  [8]
 LDCM0334  AC7 PaTu 8988t C1018(1.02); C1028(1.02)  LDD1213  [8]
 LDCM0335  AC70 PaTu 8988t C469(1.12); C1018(1.17); C1028(1.17)  LDD1214  [8]
 LDCM0336  AC71 PaTu 8988t C469(1.18); C1018(1.04); C1028(1.04)  LDD1215  [8]
 LDCM0337  AC72 PaTu 8988t C469(1.00); C1018(0.95); C1028(0.95)  LDD1216  [8]
 LDCM0338  AC73 PaTu 8988t C469(1.00); C1018(1.02); C1028(1.02)  LDD1217  [8]
 LDCM0339  AC74 PaTu 8988t C469(1.18); C1018(1.25); C1028(1.25)  LDD1218  [8]
 LDCM0340  AC75 PaTu 8988t C469(1.21); C1018(1.24); C1028(1.24)  LDD1219  [8]
 LDCM0341  AC76 PaTu 8988t C469(0.91); C1018(1.08); C1028(1.08)  LDD1220  [8]
 LDCM0342  AC77 PaTu 8988t C469(0.83); C1018(0.98); C1028(0.98)  LDD1221  [8]
 LDCM0343  AC78 PaTu 8988t C469(0.82); C1018(0.88); C1028(0.88)  LDD1222  [8]
 LDCM0344  AC79 PaTu 8988t C469(0.90); C1018(1.02); C1028(1.02)  LDD1223  [8]
 LDCM0345  AC8 PaTu 8988t C1018(1.01); C1028(1.01)  LDD1224  [8]
 LDCM0346  AC80 PaTu 8988t C469(0.89); C1018(0.86); C1028(0.86)  LDD1225  [8]
 LDCM0347  AC81 PaTu 8988t C469(0.95); C1018(1.10); C1028(1.10)  LDD1226  [8]
 LDCM0348  AC82 PaTu 8988t C469(0.97); C1018(1.07); C1028(1.07)  LDD1227  [8]
 LDCM0365  AC98 PaTu 8988t C1018(1.57); C1028(1.57)  LDD1244  [8]
 LDCM0366  AC99 PaTu 8988t C1018(1.63); C1028(1.63)  LDD1245  [8]
 LDCM0248  AKOS034007472 PaTu 8988t C1018(1.36); C1028(1.36)  LDD1127  [8]
 LDCM0356  AKOS034007680 PaTu 8988t C1018(1.16); C1028(1.16)  LDD1235  [8]
 LDCM0275  AKOS034007705 PaTu 8988t C1018(1.41); C1028(1.41)  LDD1154  [8]
 LDCM0156  Aniline NCI-H1299 11.73  LDD0403  [1]
 LDCM0367  CL1 PaTu 8988t C469(1.01)  LDD1246  [8]
 LDCM0368  CL10 PaTu 8988t C469(0.90)  LDD1247  [8]
 LDCM0369  CL100 PaTu 8988t C1018(1.39); C1028(1.39)  LDD1248  [8]
 LDCM0370  CL101 PaTu 8988t C1018(1.43); C1028(1.43)  LDD1249  [8]
 LDCM0371  CL102 PaTu 8988t C1018(1.30); C1028(1.30)  LDD1250  [8]
 LDCM0372  CL103 PaTu 8988t C1018(1.45); C1028(1.45)  LDD1251  [8]
 LDCM0373  CL104 PaTu 8988t C1018(1.45); C1028(1.45)  LDD1252  [8]
 LDCM0374  CL105 PaTu 8988t C1018(1.07); C1028(1.07)  LDD1253  [8]
 LDCM0375  CL106 PaTu 8988t C1018(1.14); C1028(1.14)  LDD1254  [8]
 LDCM0376  CL107 PaTu 8988t C1018(1.02); C1028(1.02)  LDD1255  [8]
 LDCM0377  CL108 PaTu 8988t C1018(1.14); C1028(1.14)  LDD1256  [8]
 LDCM0378  CL109 PaTu 8988t C1018(1.07); C1028(1.07)  LDD1257  [8]
 LDCM0379  CL11 PaTu 8988t C469(0.62)  LDD1258  [8]
 LDCM0380  CL110 PaTu 8988t C1018(1.24); C1028(1.24)  LDD1259  [8]
 LDCM0381  CL111 PaTu 8988t C1018(1.22); C1028(1.22)  LDD1260  [8]
 LDCM0382  CL112 PaTu 8988t C469(0.98)  LDD1261  [8]
 LDCM0383  CL113 PaTu 8988t C469(0.66)  LDD1262  [8]
 LDCM0384  CL114 PaTu 8988t C469(0.47)  LDD1263  [8]
 LDCM0385  CL115 PaTu 8988t C469(0.42)  LDD1264  [8]
 LDCM0386  CL116 PaTu 8988t C469(0.48)  LDD1265  [8]
 LDCM0387  CL117 PaTu 8988t C1018(1.49); C1028(1.49)  LDD1266  [8]
 LDCM0388  CL118 PaTu 8988t C1018(1.22); C1028(1.22)  LDD1267  [8]
 LDCM0389  CL119 PaTu 8988t C1018(1.27); C1028(1.27)  LDD1268  [8]
 LDCM0390  CL12 PaTu 8988t C469(0.65)  LDD1269  [8]
 LDCM0391  CL120 PaTu 8988t C1018(1.44); C1028(1.44)  LDD1270  [8]
 LDCM0392  CL121 PaTu 8988t C469(1.20); C1018(1.09); C1028(1.09)  LDD1271  [8]
 LDCM0393  CL122 PaTu 8988t C469(1.24); C1018(1.09); C1028(1.09)  LDD1272  [8]
 LDCM0394  CL123 PaTu 8988t C469(1.63); C1018(1.28); C1028(1.28)  LDD1273  [8]
 LDCM0395  CL124 PaTu 8988t C469(1.28); C1018(1.01); C1028(1.01)  LDD1274  [8]
 LDCM0396  CL125 HEK-293T C537(1.01); C680(0.80); C623(0.90)  LDD1600  [9]
 LDCM0397  CL126 HEK-293T C537(1.07); C680(0.82); C623(0.88); C662(0.88)  LDD1601  [9]
 LDCM0398  CL127 HEK-293T C537(0.97); C680(0.96); C623(0.87)  LDD1602  [9]
 LDCM0399  CL128 HEK-293T C680(1.05); C623(0.98)  LDD1603  [9]
 LDCM0400  CL13 PaTu 8988t C469(0.63)  LDD1279  [8]
 LDCM0401  CL14 PaTu 8988t C469(0.92)  LDD1280  [8]
 LDCM0402  CL15 PaTu 8988t C469(0.86)  LDD1281  [8]
 LDCM0403  CL16 PaTu 8988t C469(0.84)  LDD1282  [8]
 LDCM0404  CL17 PaTu 8988t C469(1.21)  LDD1283  [8]
 LDCM0405  CL18 PaTu 8988t C469(0.86)  LDD1284  [8]
 LDCM0406  CL19 PaTu 8988t C469(1.29)  LDD1285  [8]
 LDCM0407  CL2 PaTu 8988t C469(0.97)  LDD1286  [8]
 LDCM0408  CL20 PaTu 8988t C469(1.40)  LDD1287  [8]
 LDCM0409  CL21 PaTu 8988t C469(1.34)  LDD1288  [8]
 LDCM0410  CL22 PaTu 8988t C469(1.04)  LDD1289  [8]
 LDCM0411  CL23 PaTu 8988t C469(1.62)  LDD1290  [8]
 LDCM0412  CL24 PaTu 8988t C469(0.81)  LDD1291  [8]
 LDCM0413  CL25 PaTu 8988t C469(1.22)  LDD1292  [8]
 LDCM0414  CL26 PaTu 8988t C469(1.05)  LDD1293  [8]
 LDCM0415  CL27 PaTu 8988t C469(1.01)  LDD1294  [8]
 LDCM0416  CL28 PaTu 8988t C469(1.75)  LDD1295  [8]
 LDCM0417  CL29 PaTu 8988t C469(1.39)  LDD1296  [8]
 LDCM0418  CL3 PaTu 8988t C469(1.10)  LDD1297  [8]
 LDCM0419  CL30 PaTu 8988t C469(1.25)  LDD1298  [8]
 LDCM0420  CL31 HEK-293T C537(0.95); C680(1.13)  LDD1624  [9]
 LDCM0421  CL32 HEK-293T C537(0.73); C680(1.01); C623(0.89)  LDD1625  [9]
 LDCM0422  CL33 HEK-293T C537(1.24); C680(1.11); C623(1.37)  LDD1626  [9]
 LDCM0423  CL34 HEK-293T C537(0.72); C680(1.12); C623(1.26)  LDD1627  [9]
 LDCM0424  CL35 HEK-293T C680(1.14); C623(0.91)  LDD1628  [9]
 LDCM0425  CL36 HEK-293T C537(1.15); C680(1.00); C623(1.26)  LDD1629  [9]
 LDCM0426  CL37 HEK-293T C537(0.90); C680(0.85); C623(0.82)  LDD1630  [9]
 LDCM0428  CL39 HEK-293T C537(0.88); C680(0.95); C623(0.85)  LDD1632  [9]
 LDCM0429  CL4 PaTu 8988t C469(1.10)  LDD1308  [8]
 LDCM0430  CL40 HEK-293T C680(0.86); C623(0.98)  LDD1634  [9]
 LDCM0431  CL41 HEK-293T C537(0.81); C680(0.90); C623(0.97)  LDD1635  [9]
 LDCM0432  CL42 HEK-293T C537(0.91); C680(1.14); C623(0.93)  LDD1636  [9]
 LDCM0433  CL43 HEK-293T C537(0.92); C680(1.05)  LDD1637  [9]
 LDCM0434  CL44 HEK-293T C537(0.91); C680(0.93); C623(0.96)  LDD1638  [9]
 LDCM0435  CL45 HEK-293T C537(1.03); C680(1.31); C623(1.40)  LDD1639  [9]
 LDCM0436  CL46 HEK-293T C537(0.86); C680(0.98); C623(1.15)  LDD1640  [9]
 LDCM0437  CL47 HEK-293T C680(0.89); C623(1.01)  LDD1641  [9]
 LDCM0438  CL48 HEK-293T C537(1.04); C680(1.08); C623(1.16)  LDD1642  [9]
 LDCM0439  CL49 HEK-293T C537(1.05); C680(0.93); C623(0.78)  LDD1643  [9]
 LDCM0440  CL5 PaTu 8988t C469(1.04)  LDD1319  [8]
 LDCM0441  CL50 HEK-293T C537(1.30); C680(0.97); C623(0.85); C662(1.11)  LDD1645  [9]
 LDCM0443  CL52 HEK-293T C680(1.04); C623(1.09)  LDD1646  [9]
 LDCM0444  CL53 HEK-293T C537(1.08); C680(0.98); C623(0.91)  LDD1647  [9]
 LDCM0445  CL54 HEK-293T C537(1.11); C680(1.15); C623(0.85)  LDD1648  [9]
 LDCM0446  CL55 HEK-293T C537(0.81); C680(1.06)  LDD1649  [9]
 LDCM0447  CL56 HEK-293T C537(0.88); C680(1.01); C623(0.93)  LDD1650  [9]
 LDCM0448  CL57 HEK-293T C537(0.87); C680(1.41); C623(1.16)  LDD1651  [9]
 LDCM0449  CL58 HEK-293T C537(1.01); C680(0.75); C623(1.31)  LDD1652  [9]
 LDCM0450  CL59 HEK-293T C680(1.05); C623(0.93)  LDD1653  [9]
 LDCM0451  CL6 PaTu 8988t C469(0.94)  LDD1330  [8]
 LDCM0452  CL60 HEK-293T C537(1.21); C680(1.12); C623(1.23)  LDD1655  [9]
 LDCM0453  CL61 PaTu 8988t C469(1.18)  LDD1332  [8]
 LDCM0454  CL62 PaTu 8988t C469(0.71)  LDD1333  [8]
 LDCM0455  CL63 PaTu 8988t C469(0.93)  LDD1334  [8]
 LDCM0456  CL64 PaTu 8988t C469(1.24)  LDD1335  [8]
 LDCM0457  CL65 PaTu 8988t C469(1.06)  LDD1336  [8]
 LDCM0458  CL66 PaTu 8988t C469(0.87)  LDD1337  [8]
 LDCM0459  CL67 PaTu 8988t C469(1.40)  LDD1338  [8]
 LDCM0460  CL68 PaTu 8988t C469(2.01)  LDD1339  [8]
 LDCM0461  CL69 PaTu 8988t C469(1.80)  LDD1340  [8]
 LDCM0462  CL7 PaTu 8988t C469(1.14)  LDD1341  [8]
 LDCM0463  CL70 PaTu 8988t C469(1.38)  LDD1342  [8]
 LDCM0464  CL71 PaTu 8988t C469(1.00)  LDD1343  [8]
 LDCM0465  CL72 PaTu 8988t C469(0.78)  LDD1344  [8]
 LDCM0466  CL73 PaTu 8988t C469(1.24)  LDD1345  [8]
 LDCM0467  CL74 PaTu 8988t C469(1.26)  LDD1346  [8]
 LDCM0469  CL76 HEK-293T C680(0.97); C623(0.98)  LDD1672  [9]
 LDCM0470  CL77 HEK-293T C537(1.02); C680(0.96); C623(0.84)  LDD1673  [9]
 LDCM0471  CL78 HEK-293T C537(0.92); C680(0.93); C623(0.84)  LDD1674  [9]
 LDCM0472  CL79 HEK-293T C537(0.96); C680(1.19)  LDD1675  [9]
 LDCM0473  CL8 PaTu 8988t C469(0.90)  LDD1352  [8]
 LDCM0474  CL80 HEK-293T C537(0.86); C680(0.92); C623(0.96)  LDD1677  [9]
 LDCM0475  CL81 HEK-293T C537(1.17); C680(1.29); C623(1.13)  LDD1678  [9]
 LDCM0476  CL82 HEK-293T C537(0.96); C680(0.83); C623(1.03)  LDD1679  [9]
 LDCM0477  CL83 HEK-293T C680(1.01); C623(0.92)  LDD1680  [9]
 LDCM0478  CL84 HEK-293T C537(0.85); C680(1.12); C623(1.22)  LDD1681  [9]
 LDCM0479  CL85 HEK-293T C537(1.07); C680(1.15); C623(0.84)  LDD1682  [9]
 LDCM0480  CL86 HEK-293T C537(0.90); C680(1.00); C623(0.87); C662(1.02)  LDD1683  [9]
 LDCM0481  CL87 HEK-293T C537(0.86); C680(1.06); C623(0.85)  LDD1684  [9]
 LDCM0482  CL88 HEK-293T C680(1.04); C623(1.00)  LDD1685  [9]
 LDCM0483  CL89 HEK-293T C537(0.96); C680(0.92); C623(0.83)  LDD1686  [9]
 LDCM0484  CL9 PaTu 8988t C469(0.80)  LDD1363  [8]
 LDCM0485  CL90 HEK-293T C537(0.83); C680(0.73); C623(1.15)  LDD1688  [9]
 LDCM0486  CL91 PaTu 8988t C1018(1.10); C1028(1.10)  LDD1365  [8]
 LDCM0487  CL92 PaTu 8988t C1018(1.52); C1028(1.52)  LDD1366  [8]
 LDCM0488  CL93 PaTu 8988t C1018(1.39); C1028(1.39)  LDD1367  [8]
 LDCM0489  CL94 PaTu 8988t C1018(1.44); C1028(1.44)  LDD1368  [8]
 LDCM0490  CL95 PaTu 8988t C1018(2.34); C1028(2.34)  LDD1369  [8]
 LDCM0491  CL96 PaTu 8988t C1018(1.46); C1028(1.46)  LDD1370  [8]
 LDCM0492  CL97 PaTu 8988t C1018(1.39); C1028(1.39)  LDD1371  [8]
 LDCM0493  CL98 PaTu 8988t C1018(1.58); C1028(1.58)  LDD1372  [8]
 LDCM0494  CL99 PaTu 8988t C1018(1.49); C1028(1.49)  LDD1373  [8]
 LDCM0495  E2913 HEK-293T C537(0.88); C680(0.94); C623(0.84)  LDD1698  [9]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C862(1.27)  LDD1702  [10]
 LDCM0468  Fragment33 PaTu 8988t C469(1.23)  LDD1347  [8]
 LDCM0427  Fragment51 HEK-293T C537(1.21); C680(0.96); C623(0.83); C662(0.95)  LDD1631  [9]
 LDCM0022  KB02 HEK-293T C680(1.07)  LDD1492  [9]
 LDCM0023  KB03 HEK-293T C680(1.08)  LDD1497  [9]
 LDCM0024  KB05 MEWO C735(2.54)  LDD3319  [2]

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
3 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
4 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
5 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
6 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
7 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
8 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
9 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
10 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761