Details of the Target

General Information of Target

Target ID LDTP08392
Target Name 5'-3' DNA helicase ZGRF1 (ZGRF1)
Gene Name ZGRF1
Gene ID 55345
Synonyms
C4orf21; 5'-3' DNA helicase ZGRF1; EC 5.6.2.3; GRF-type zinc finger domain-containing protein 1
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MESQEFIVLYTHQKMKKSKVWQDGILKITHLGNKAILYDDKGACLESLFLKCLEVKPGDD
LESDRYLITVEEVKVAGAIGIVKQNVNKEAPELNSRTFISSGRSLGCQPSGLKRKFTGFQ
GPRQVPKKMVIMESGESAASHEAKKTGPTIFSPFCSMPPLFPTVGKKDVNNILADPENIV
TYKNRERNAMDFSSVFSPSFQINPEVLCEENYFCSPVNSGNKLSDSLLTNEPVKRDSLAS
HYSGVSQNIRSKAQILALLKSESSSSCEELNSEMTEHFPQKQPQGSLKIATKPKYLIQQE
ECAEMKSTENLYYQHQSENTMRNKSRWAMYLSSQSSPIHSSTVDGNDTERKPKAQEDDVN
SNLKDLSLQKIIQFVETYAEERKKYNVDQSVGNNDPSWNQEVKLEIPSFNESSSLQVTCS
SAENDGILSESDIQEDNKIPFNQNDKGCIKGSVLIKENAQEVNTCGTLEKEYEQSESSLP
ELKHLQIESSNNSRISDDITDMISESKMDNESLNSIHESLSNVTQPFLEVTFNLNNFETS
DTEEESQESNKISQDSESWVKDILVNDGNSCFQKRSENTNCEEIEGEHLPFLTSVSDKPT
VTFPVKETLPSQFCDKTYVGFDMGICKTENTGKEIEEYSDTLSNFESFKWTDAVYGDNKE
DANKPIQEVRINYDFALPPNKSKGINMNLHIPHIQNQIAENSNLFSEDAQPQPFILGSDL
DKNDEHVLPSTSSSDNSVQLLNTNQNHYECIALDKSNTHISNSLFYPLGKKHLISKDTEA
HISEPEDLGKIRSPPPDHVEVETAREGKQYWNPRNSSELSGLVNTISILKSLCEHSTALD
SLEILKKKNTVFQQGTQQTYEPDSPPEVRKPFITVVSPKSPHLHKDSQQILKEDEVELSE
PLQSVQFSSSGSKEETAFQAVIPKQIERKTCDPKPVEFQGHQVKGSATSGVMVRGHSSQL
GCSQFPDSTEYENFMTETPELPSTCMQIDFLQVTSPEENISTLSPVSTFSLNSRDEDFMV
EFSETSLKARTLPDDLHFLNLEGMKKSRSLENENLQRLSLLSRTQVPLITLPRTDGPPDL
DSHSYMINSNTYESSGSPMLNLCEKSAVLSFSIEPEDQNETFFSEESREVNPGDVSLNNI
STQSKWLKYQNTSQCNVATPNRVDKRITDGFFAEAVSGMHFRDTSERQSDAVNESSLDSV
HLQMIKGMLYQQRQDFSSQDSVSRKKVLSLNLKQTSKTEEIKNVLGGSTCYNYSVKDLQE
ISGSELCFPSGQKIKSAYLPQRQIHIPAVFQSPAHYKQTFTSCLIEHLNILLFGLAQNLQ
KALSKVDISFYTSLKGEKLKNAENNVPSCHHSQPAKLVMVKKEGPNKGRLFYTCDGPKAD
RCKFFKWLEDVTPGYSTQEGARPGMVLSDIKSIGLYLRSQKIPLYEECQLLVRKGFDFQR
KQYGKLKKFTTVNPEFYNEPKTKLYLKLSRKERSSAYSKNDLWVVSKTLDFELDTFIACS
AFFGPSSINEIEILPLKGYFPSNWPTNMVVHALLVCNASTELTTLKNIQDYFNPATLPLT
QYLLTTSSPTIVSNKRVSKRKFIPPAFTNVSTKFELLSLGATLKLASELIQVHKLNKDQA
TALIQIAQMMASHESIEEVKELQTHTFPITIIHGVFGAGKSYLLAVVILFFVQLFEKSEA
PTIGNARPWKLLISSSTNVAVDRVLLGLLSLGFENFIRVGSVRKIAKPILPYSLHAGSEN
ESEQLKELHALMKEDLTPTERVYVRKSIEQHKLGTNRTLLKQVRVVGVTCAACPFPCMND
LKFPVVVLDECSQITEPASLLPIARFECEKLILVGDPKQLPPTIQGSDAAHENGLEQTLF
DRLCLMGHKPILLRTQYRCHPAISAIANDLFYKGALMNGVTEIERSPLLEWLPTLCFYNV
KGLEQIERDNSFHNVAEATFTLKLIQSLIASGIAGSMIGVITLYKSQMYKLCHLLSAVDF
HHPDIKTVQVSTVDAFQGAEKEIIILSCVRTRQVGFIDSEKRMNVALTRGKRHLLIVGNL
ACLRKNQLWGRVIQHCEGREDGLQHANQYEPQLNHLLKDYFEKQVEEKQKKKSEKEKSKD
KSHS
Target Bioclass
Enzyme
Subcellular location
Membrane
Function
5'-3' DNA helicase which is recruited to sites of DNA damage and promotes repair of replication-blocking DNA lesions through stimulation of homologous recombination (HR). Promotes HR by directly stimulating RAD51-mediated strand exchange activity. Not required to load RAD51 at sites of DNA damage but promotes recombinational repair after RAD51 recruitment. Also promotes HR by positively regulating EXO1-mediated DNA end resection of double-strand breaks. Required for recruitment of replication protein RPA2 to DNA damage sites. Promotes the initiation of the G2/M checkpoint but not its maintenance. Catalyzes Holliday junction branch migration and dissociation of D-loops and DNA flaps.
Uniprot ID
Q86YA3
Ensemble ID
ENST00000309071.9
HGNC ID
HGNC:25654

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
DU145 SNV: p.K1338Ter .
ECC2 SNV: p.E779K .
HCT15 SNV: p.A662V .
KO52 SNV: p.R2051Ter .
KYSE150 SNV: p.E2002D .
KYSE180 SNV: p.P604S .
LS513 SNV: p.K1690N .
MCC13 SNV: p.P795S; p.E1240K .
MDAMB436 Deletion: p.E269_E276del .
MDAMB453 SNV: p.E92Q .
NCIH1703 SNV: p.A328S .
NCIH1793 SNV: p.A43T .
NCIH1975 SNV: p.R250T .
NCIH23 SNV: p.Q1065L .
OVK18 Deletion: p.E1641NfsTer27
SNV: p.S1591G		 .
SNU1 SNV: p.Q1219R .
SUPT1 SNV: p.E1399G .
ZR751 SNV: p.F116S .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 4 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
IA-alkyne
 Probe Info  		C107(10.72)  LDD1706  [1]
DBIA
 Probe Info  		C1250(0.98)  LDD0547  [2]
IPM
 Probe Info  		N.A.  LDD2156  [3]
AOyne
 Probe Info  		15.00  LDD0443  [4]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HEK-293T C1811(1.41); C44(1.07)  LDD1507  [5]
 LDCM0215  AC10 HEK-293T C44(0.94); C1374(0.99)  LDD1508  [5]
 LDCM0230  AC113 HCT 116 C1250(0.98)  LDD0547  [2]
 LDCM0231  AC114 HCT 116 C1250(0.91)  LDD0548  [2]
 LDCM0232  AC115 HCT 116 C1250(0.84)  LDD0549  [2]
 LDCM0233  AC116 HCT 116 C1250(0.87)  LDD0550  [2]
 LDCM0234  AC117 HCT 116 C1250(0.83)  LDD0551  [2]
 LDCM0235  AC118 HCT 116 C1250(0.97)  LDD0552  [2]
 LDCM0236  AC119 HCT 116 C1250(1.11)  LDD0553  [2]
 LDCM0237  AC12 HEK-293T C155(0.80); C44(1.15)  LDD1510  [5]
 LDCM0238  AC120 HCT 116 C1250(1.00)  LDD0555  [2]
 LDCM0239  AC121 HCT 116 C1250(0.65)  LDD0556  [2]
 LDCM0240  AC122 HCT 116 C1250(0.98)  LDD0557  [2]
 LDCM0241  AC123 HCT 116 C1250(0.88)  LDD0558  [2]
 LDCM0242  AC124 HCT 116 C1250(0.78)  LDD0559  [2]
 LDCM0243  AC125 HCT 116 C1250(1.28)  LDD0560  [2]
 LDCM0244  AC126 HCT 116 C1250(1.01)  LDD0561  [2]
 LDCM0245  AC127 HCT 116 C1250(0.97)  LDD0562  [2]
 LDCM0259  AC14 HEK-293T C44(0.97)  LDD1512  [5]
 LDCM0270  AC15 HEK-293T C1374(1.10); C52(1.15)  LDD1513  [5]
 LDCM0276  AC17 HEK-293T C1811(1.32); C44(0.91)  LDD1515  [5]
 LDCM0277  AC18 HEK-293T C44(0.96); C1374(1.14)  LDD1516  [5]
 LDCM0279  AC2 HEK-293T C44(0.93); C1374(0.85)  LDD1518  [5]
 LDCM0280  AC20 HEK-293T C155(0.84); C44(1.06)  LDD1519  [5]
 LDCM0282  AC22 HEK-293T C44(0.98)  LDD1521  [5]
 LDCM0283  AC23 HEK-293T C1374(1.39); C52(0.91)  LDD1522  [5]
 LDCM0284  AC24 HEK-293T C1811(1.01)  LDD1523  [5]
 LDCM0285  AC25 HCT 116 C1250(0.98)  LDD0602  [2]
 LDCM0286  AC26 HCT 116 C1250(1.22)  LDD0603  [2]
 LDCM0287  AC27 HCT 116 C1250(1.37)  LDD0604  [2]
 LDCM0288  AC28 HCT 116 C1250(1.24)  LDD0605  [2]
 LDCM0289  AC29 HCT 116 C1250(1.49)  LDD0606  [2]
 LDCM0291  AC30 HCT 116 C1250(1.43)  LDD0608  [2]
 LDCM0292  AC31 HCT 116 C1250(1.26)  LDD0609  [2]
 LDCM0293  AC32 HCT 116 C1250(1.39)  LDD0610  [2]
 LDCM0294  AC33 HCT 116 C1250(1.15)  LDD0611  [2]
 LDCM0295  AC34 HCT 116 C1250(1.28)  LDD0612  [2]
 LDCM0297  AC36 HEK-293T C155(0.90); C44(1.15)  LDD1536  [5]
 LDCM0299  AC38 HEK-293T C44(0.95)  LDD1538  [5]
 LDCM0300  AC39 HEK-293T C1374(1.03); C52(1.09)  LDD1539  [5]
 LDCM0301  AC4 HEK-293T C155(0.98); C44(1.03)  LDD1540  [5]
 LDCM0302  AC40 HEK-293T C1811(1.05)  LDD1541  [5]
 LDCM0303  AC41 HEK-293T C1811(1.44); C44(1.04)  LDD1542  [5]
 LDCM0304  AC42 HEK-293T C44(1.01); C1374(1.15)  LDD1543  [5]
 LDCM0306  AC44 HEK-293T C155(0.96); C44(1.11)  LDD1545  [5]
 LDCM0308  AC46 HCT 116 C1250(0.87)  LDD0625  [2]
 LDCM0309  AC47 HCT 116 C1250(1.04)  LDD0626  [2]
 LDCM0310  AC48 HCT 116 C1250(0.78)  LDD0627  [2]
 LDCM0311  AC49 HCT 116 C1250(1.09)  LDD0628  [2]
 LDCM0313  AC50 HCT 116 C1250(1.01)  LDD0630  [2]
 LDCM0314  AC51 HCT 116 C1250(0.79)  LDD0631  [2]
 LDCM0315  AC52 HCT 116 C1250(0.84)  LDD0632  [2]
 LDCM0316  AC53 HCT 116 C1250(1.00)  LDD0633  [2]
 LDCM0317  AC54 HCT 116 C1250(0.81)  LDD0634  [2]
 LDCM0318  AC55 HCT 116 C1250(1.08)  LDD0635  [2]
 LDCM0319  AC56 HCT 116 C1250(1.00)  LDD0636  [2]
 LDCM0320  AC57 HEK-293T C1811(1.18); C44(1.04)  LDD1559  [5]
 LDCM0321  AC58 HEK-293T C44(1.00); C1374(0.83)  LDD1560  [5]
 LDCM0323  AC6 HEK-293T C44(0.97)  LDD1562  [5]
 LDCM0324  AC60 HEK-293T C155(0.95); C44(1.06)  LDD1563  [5]
 LDCM0326  AC62 HEK-293T C44(0.97)  LDD1565  [5]
 LDCM0327  AC63 HEK-293T C1374(1.24); C52(1.00)  LDD1566  [5]
 LDCM0328  AC64 HEK-293T C1811(1.11)  LDD1567  [5]
 LDCM0334  AC7 HEK-293T C1374(1.18); C52(1.00)  LDD1568  [5]
 LDCM0345  AC8 HEK-293T C1811(0.95)  LDD1569  [5]
 LDCM0349  AC83 HCT 116 C1250(0.72)  LDD0666  [2]
 LDCM0350  AC84 HCT 116 C1250(0.80)  LDD0667  [2]
 LDCM0351  AC85 HCT 116 C1250(0.88)  LDD0668  [2]
 LDCM0352  AC86 HCT 116 C1250(0.84)  LDD0669  [2]
 LDCM0353  AC87 HCT 116 C1250(0.70)  LDD0670  [2]
 LDCM0354  AC88 HCT 116 C1250(0.80)  LDD0671  [2]
 LDCM0355  AC89 HCT 116 C1250(0.79)  LDD0672  [2]
 LDCM0357  AC90 HCT 116 C1250(0.91)  LDD0674  [2]
 LDCM0358  AC91 HCT 116 C1250(0.75)  LDD0675  [2]
 LDCM0359  AC92 HCT 116 C1250(0.73)  LDD0676  [2]
 LDCM0360  AC93 HCT 116 C1250(0.80)  LDD0677  [2]
 LDCM0361  AC94 HCT 116 C1250(0.76)  LDD0678  [2]
 LDCM0362  AC95 HCT 116 C1250(0.80)  LDD0679  [2]
 LDCM0363  AC96 HCT 116 C1250(0.75)  LDD0680  [2]
 LDCM0364  AC97 HCT 116 C1250(0.97)  LDD0681  [2]
 LDCM0356  AKOS034007680 HEK-293T C1811(1.34); C44(0.98)  LDD1570  [5]
 LDCM0275  AKOS034007705 HEK-293T C1811(1.18)  LDD1514  [5]
 LDCM0367  CL1 HCT 116 C1250(1.04)  LDD0684  [2]
 LDCM0368  CL10 HCT 116 C1250(1.04)  LDD0685  [2]
 LDCM0370  CL101 HEK-293T C465(0.91); C1811(0.95)  LDD1574  [5]
 LDCM0372  CL103 HEK-293T C44(1.00)  LDD1576  [5]
 LDCM0374  CL105 HEK-293T C465(0.92); C1811(0.95)  LDD1578  [5]
 LDCM0376  CL107 HEK-293T C44(1.00)  LDD1580  [5]
 LDCM0378  CL109 HEK-293T C465(0.89); C1811(1.00)  LDD1582  [5]
 LDCM0379  CL11 HCT 116 C1250(1.13)  LDD0696  [2]
 LDCM0381  CL111 HEK-293T C44(0.92)  LDD1585  [5]
 LDCM0382  CL112 HCT 116 C1250(1.12)  LDD0699  [2]
 LDCM0383  CL113 HCT 116 C1250(1.32)  LDD0700  [2]
 LDCM0384  CL114 HCT 116 C1250(1.58)  LDD0701  [2]
 LDCM0385  CL115 HCT 116 C1250(1.33)  LDD0702  [2]
 LDCM0386  CL116 HCT 116 C1250(1.21)  LDD0703  [2]
 LDCM0387  CL117 HEK-293T C465(1.02); C1811(0.93)  LDD1591  [5]
 LDCM0389  CL119 HEK-293T C44(1.07)  LDD1593  [5]
 LDCM0390  CL12 HCT 116 C1250(1.22)  LDD0707  [2]
 LDCM0392  CL121 HCT 116 C1250(0.89)  LDD0709  [2]
 LDCM0393  CL122 HCT 116 C1250(0.88)  LDD0710  [2]
 LDCM0394  CL123 HCT 116 C1250(0.77)  LDD0711  [2]
 LDCM0395  CL124 HCT 116 C1250(1.08)  LDD0712  [2]
 LDCM0396  CL125 HEK-293T C465(0.92); C1811(1.05)  LDD1600  [5]
 LDCM0398  CL127 HEK-293T C44(1.05)  LDD1602  [5]
 LDCM0400  CL13 HCT 116 C1250(1.17)  LDD0717  [2]
 LDCM0401  CL14 HCT 116 C1250(1.18)  LDD0718  [2]
 LDCM0402  CL15 HCT 116 C1250(1.42)  LDD0719  [2]
 LDCM0403  CL16 HCT 116 C1250(1.17)  LDD0720  [2]
 LDCM0404  CL17 HCT 116 C1250(0.98)  LDD0721  [2]
 LDCM0405  CL18 HCT 116 C1250(1.05)  LDD0722  [2]
 LDCM0406  CL19 HCT 116 C1250(1.06)  LDD0723  [2]
 LDCM0407  CL2 HCT 116 C1250(0.99)  LDD0724  [2]
 LDCM0408  CL20 HCT 116 C1250(1.01)  LDD0725  [2]
 LDCM0409  CL21 HCT 116 C1250(1.22)  LDD0726  [2]
 LDCM0410  CL22 HCT 116 C1250(0.99)  LDD0727  [2]
 LDCM0411  CL23 HCT 116 C1250(1.24)  LDD0728  [2]
 LDCM0412  CL24 HCT 116 C1250(1.00)  LDD0729  [2]
 LDCM0413  CL25 HCT 116 C1250(1.17)  LDD0730  [2]
 LDCM0414  CL26 HCT 116 C1250(1.27)  LDD0731  [2]
 LDCM0415  CL27 HCT 116 C1250(1.09)  LDD0732  [2]
 LDCM0416  CL28 HCT 116 C1250(1.26)  LDD0733  [2]
 LDCM0417  CL29 HCT 116 C1250(1.12)  LDD0734  [2]
 LDCM0418  CL3 HCT 116 C1250(1.01)  LDD0735  [2]
 LDCM0419  CL30 HCT 116 C1250(1.11)  LDD0736  [2]
 LDCM0421  CL32 HEK-293T C155(0.90); C44(1.03)  LDD1625  [5]
 LDCM0423  CL34 HEK-293T C44(1.01)  LDD1627  [5]
 LDCM0424  CL35 HEK-293T C1374(0.80); C52(1.54)  LDD1628  [5]
 LDCM0425  CL36 HEK-293T C1811(0.96)  LDD1629  [5]
 LDCM0426  CL37 HEK-293T C465(0.92); C1811(1.02)  LDD1630  [5]
 LDCM0428  CL39 HEK-293T C44(0.99)  LDD1632  [5]
 LDCM0429  CL4 HCT 116 C1250(1.79)  LDD0746  [2]
 LDCM0431  CL41 HEK-293T C1811(1.10); C44(0.99)  LDD1635  [5]
 LDCM0432  CL42 HEK-293T C44(0.98); C1374(1.07)  LDD1636  [5]
 LDCM0434  CL44 HEK-293T C155(0.84); C44(1.12)  LDD1638  [5]
 LDCM0436  CL46 HEK-293T C44(1.06)  LDD1640  [5]
 LDCM0437  CL47 HEK-293T C1374(1.07); C52(1.51)  LDD1641  [5]
 LDCM0438  CL48 HEK-293T C1811(0.86)  LDD1642  [5]
 LDCM0439  CL49 HEK-293T C465(0.87); C1811(0.96)  LDD1643  [5]
 LDCM0440  CL5 HCT 116 C1250(0.92)  LDD0757  [2]
 LDCM0444  CL53 HEK-293T C1811(1.16); C44(1.02)  LDD1647  [5]
 LDCM0445  CL54 HEK-293T C44(1.04); C1374(0.77)  LDD1648  [5]
 LDCM0447  CL56 HEK-293T C155(0.84); C44(1.15)  LDD1650  [5]
 LDCM0449  CL58 HEK-293T C44(1.02)  LDD1652  [5]
 LDCM0450  CL59 HEK-293T C1374(1.06); C52(1.42)  LDD1653  [5]
 LDCM0451  CL6 HCT 116 C1250(1.09)  LDD0768  [2]
 LDCM0452  CL60 HEK-293T C1811(1.07)  LDD1655  [5]
 LDCM0453  CL61 HEK-293T C465(0.83); C1811(1.12)  LDD1656  [5]
 LDCM0455  CL63 HEK-293T C44(1.03)  LDD1658  [5]
 LDCM0457  CL65 HEK-293T C1811(1.60); C44(1.11)  LDD1660  [5]
 LDCM0458  CL66 HEK-293T C44(0.96); C1374(1.06)  LDD1661  [5]
 LDCM0460  CL68 HEK-293T C155(0.81); C44(1.14)  LDD1663  [5]
 LDCM0462  CL7 HCT 116 C1250(1.13)  LDD0779  [2]
 LDCM0463  CL70 HEK-293T C44(1.03)  LDD1666  [5]
 LDCM0464  CL71 HEK-293T C1374(1.07); C52(1.30)  LDD1667  [5]
 LDCM0465  CL72 HEK-293T C1811(1.05)  LDD1668  [5]
 LDCM0466  CL73 HEK-293T C465(0.89); C1811(0.93)  LDD1669  [5]
 LDCM0469  CL76 HCT 116 C1250(1.04)  LDD0786  [2]
 LDCM0470  CL77 HCT 116 C1250(1.14)  LDD0787  [2]
 LDCM0471  CL78 HCT 116 C1250(0.95)  LDD0788  [2]
 LDCM0472  CL79 HCT 116 C1250(1.14)  LDD0789  [2]
 LDCM0473  CL8 HCT 116 C1250(1.08)  LDD0790  [2]
 LDCM0474  CL80 HCT 116 C1250(1.02)  LDD0791  [2]
 LDCM0475  CL81 HCT 116 C1250(1.20)  LDD0792  [2]
 LDCM0476  CL82 HCT 116 C1250(0.95)  LDD0793  [2]
 LDCM0477  CL83 HCT 116 C1250(1.15)  LDD0794  [2]
 LDCM0478  CL84 HCT 116 C1250(1.09)  LDD0795  [2]
 LDCM0479  CL85 HCT 116 C1250(1.29)  LDD0796  [2]
 LDCM0480  CL86 HCT 116 C1250(0.93)  LDD0797  [2]
 LDCM0481  CL87 HCT 116 C1250(1.20)  LDD0798  [2]
 LDCM0482  CL88 HCT 116 C1250(0.95)  LDD0799  [2]
 LDCM0483  CL89 HCT 116 C1250(0.90)  LDD0800  [2]
 LDCM0484  CL9 HCT 116 C1250(1.32)  LDD0801  [2]
 LDCM0485  CL90 HCT 116 C1250(1.69)  LDD0802  [2]
 LDCM0487  CL92 HEK-293T C155(0.87); C44(1.11)  LDD1690  [5]
 LDCM0489  CL94 HEK-293T C44(1.08)  LDD1692  [5]
 LDCM0490  CL95 HEK-293T C1374(1.29); C52(1.12)  LDD1693  [5]
 LDCM0491  CL96 HEK-293T C1811(0.85)  LDD1694  [5]
 LDCM0492  CL97 HEK-293T C465(0.83); C1811(0.84)  LDD1695  [5]
 LDCM0494  CL99 HEK-293T C44(1.03)  LDD1697  [5]
 LDCM0495  E2913 HEK-293T C44(1.04)  LDD1698  [5]
 LDCM0468  Fragment33 HEK-293T C44(1.01)  LDD1671  [5]
 LDCM0022  KB02 HEK-293T C2056(0.95)  LDD1492  [5]
 LDCM0023  KB03 HEK-293T C2056(1.04)  LDD1497  [5]
 LDCM0024  KB05 HEK-293T C2056(0.88)  LDD1502  [5]

References

1 An Activity-Guided Map of Electrophile-Cysteine Interactions in Primary Human T Cells. Cell. 2020 Aug 20;182(4):1009-1026.e29. doi: 10.1016/j.cell.2020.07.001. Epub 2020 Jul 29.
2 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
3 Benchmarking Cleavable Biotin Tags for Peptide-Centric Chemoproteomics. J Proteome Res. 2022 May 6;21(5):1349-1358. doi: 10.1021/acs.jproteome.2c00174. Epub 2022 Apr 25.
Mass spectrometry data entry: PXD031019
4 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
5 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402