Details of the Target

General Information of Target

Target ID LDTP08330
Target Name Myotubularin-related protein 13 (SBF2)
Gene Name SBF2
Gene ID 81846
Synonyms
CMT4B2; KIAA1766; MTMR13; Myotubularin-related protein 13; Inactive phosphatidylinositol 3-phosphatase 13; SET-binding factor 2
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MARLADYFIVVGYDHEKPGSGEGLGKIIQRFPQKDWDDTPFPQGIELFCQPGGWQLSRER
KQPTFFVVVLTDIDSDRHYCSCLTFYEAEINLQGTKKEEIEGEAKVSGLIQPAEVFAPKS
LVLVSRLYYPEIFRACLGLIYTVYVDSLNVSLESLIANLCACLVPAAGGSQKLFSLGAGD
RQLIQTPLHDSLPITGTSVALLFQQLGIQNVLSLFCAVLTENKVLFHSASFQRLSDACRA
LESLMFPLKYSYPYIPILPAQLLEVLSSPTPFIIGVHSVFKTDVHELLDVIIADLDGGTI
KIPECIHLSSLPEPLLHQTQSALSLILHPDLEVADHAFPPPRTALSHSKMLDKEVRAVFL
RLFAQLFQGYRSCLQLIRIHAEPVIHFHKTAFLGQRGLVENDFLTKVLSGMAFAGFVSER
GPPYRSCDLFDELVAFEVERIKVEENNPVKMIKHVRELAEQLFKNENPNPHMAFQKVPRP
TEGSHLRVHILPFPEINEARVQELIQENVAKNQNAPPATRIEKKCVVPAGPPVVSIMDKV
TTVFNSAQRLEVVRNCISFIFENKILETEKTLPAALRALKGKAARQCLTDELGLHVQQNR
AILDHQQFDYIIRMMNCTLQDCSSLEEYNIAAALLPLTSAFYRKLAPGVSQFAYTCVQDH
PIWTNQQFWETTFYNAVQEQVRSLYLSAKEDNHAPHLKQKDKLPDDHYQEKTAMDLAAEQ
LRLWPTLSKSTQQELVQHEESTVFSQAIHFANLMVNLLVPLDTSKNKLLRTSAPGDWESG
SNSIVTNSIAGSVAESYDTESGFEDSENTDIANSVVRFITRFIDKVCTESGVTQDHIKSL
HCMIPGIVAMHIETLEAVHRESRRLPPIQKPKILRPALLPGEEIVCEGLRVLLDPDGREE
ATGGLLGGPQLLPAEGALFLTTYRILFRGTPHDQLVGEQTVVRSFPIASITKEKKITMQN
QLQQNMQEGLQITSASFQLIKVAFDEEVSPEVVEIFKKQLMKFRYPQSIFSTFAFAAGQT
TPQIILPKQKEKNTSFRTFSKTIVKGAKRAGKMTIGRQYLLKKKTGTIVEERVNRPGWNE
DDDVSVSDESELPTSTTLKASEKSTMEQLVEKACFRDYQRLGLGTISGSSSRSRPEYFRI
TASNRMYSLCRSYPGLLVVPQAVQDSSLPRVARCYRHNRLPVVCWKNSRSGTLLLRSGGF
HGKGVVGLFKSQNSPQAAPTSSLESSSSIEQEKYLQALLNAVSVHQKLRGNSTLTVRPAF
ALSPGVWASLRSSTRLISSPTSFIDVGARLAGKDHSASFSNSSYLQNQLLKRQAALYIFG
EKSQLRNFKVEFALNCEFVPVEFHEIRQVKASFKKLMRACIPSTIPTDSEVTFLKALGDS
EWFPQLHRIMQLAVVVSEVLENGSSVLVCLEEGWDITAQVTSLVQLLSDPFYRTLEGFQM
LVEKEWLSFGHKFSQRSSLTLNCQGSGFAPVFLQFLDCVHQVHNQYPTEFEFNLYYLKFL
AFHYVSNRFKTFLLDSDYERLEHGTLFDDKGEKHAKKGVCIWECIDRMHKRSPIFFNYLY
SPLEIEALKPNVNVSSLKKWDYYIEETLSTGPSYDWMMLTPKHFPSEDSDLAGEAGPRSQ
RRTVWPCYDDVSCTQPDALTSLFSEIEKLEHKLNQAPEKWQQLWERVTVDLKEEPRTDRS
QRHLSRSPGIVSTNLPSYQKRSLLHLPDSSMGEEQNSSISPSNGVERRAATLYSQYTSKN
DENRSFEGTLYKRGALLKGWKPRWFVLDVTKHQLRYYDSGEDTSCKGHIDLAEVEMVIPA
GPSMGAPKHTSDKAFFDLKTSKRVYNFCAQDGQSAQQWMDKIQSCISDA
Target Bioclass
Enzyme
Family
Protein-tyrosine phosphatase family, Non-receptor class myotubularin subfamily
Subcellular location
Cytoplasm
Function
Guanine nucleotide exchange factor (GEF) which activates RAB21 and possibly RAB28. Promotes the exchange of GDP to GTP, converting inactive GDP-bound Rab proteins into their active GTP-bound form. In response to starvation-induced autophagy, activates RAB21 which in turn binds to and regulates SNARE protein VAMP8 endolysosomal transport required for SNARE-mediated autophagosome-lysosome fusion. Acts as an adapter for the phosphatase MTMR2. Increases MTMR2 catalytic activity towards phosphatidylinositol 3,5-bisphosphate and to a lesser extent towards phosphatidylinositol 3-phosphate.
Uniprot ID
Q86WG5
Ensemble ID
ENST00000256190.13
HGNC ID
HGNC:2135

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
CAL51 SNV: p.S1323L .
CALU1 SNV: p.C216G DBIA    Probe Info 
DOTC24510 SNV: p.P448L .
HCT116 SNV: p.H386Y .
HCT15 SNV: p.T820P; p.I947N .
HEC1 SNV: p.R821Ter DBIA    Probe Info 
HEC1B SNV: p.R821Ter; p.G881Ter .
HT SNV: p.A1218T .
JURKAT SNV: p.R396H .
KMCH1 SNV: p.L92I DBIA    Probe Info 
MCAS SNV: p.L92R .
MCC26 SNV: p.H388Y DBIA    Probe Info 
MDAMB453 SNV: p.E1522K .
MEC1 SNV: p.E313D .
MEWO SNV: p.P478L DBIA    Probe Info 
OSRC2 SNV: p.V355L .
OVISE SNV: p.Q1161E .
OVK18 SNV: p.Q1635R .
RKO SNV: p.M1711I .
SNGM SNV: p.P63S DBIA    Probe Info 
SNU869 SNV: p.T542I .
THP1 SNV: p.F1502L .
TYKNU SNV: p.L295M .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 2 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C1184(1.25); C1540(0.69)  LDD0531  [1]
IPM
 Probe Info  		N.A.  LDD2156  [2]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HCT 116 C1184(1.25); C1540(0.69)  LDD0531  [1]
 LDCM0215  AC10 PaTu 8988t C1184(0.84)  LDD1094  [1]
 LDCM0226  AC11 PaTu 8988t C1184(0.86)  LDD1105  [1]
 LDCM0237  AC12 PaTu 8988t C1184(0.84)  LDD1116  [1]
 LDCM0259  AC14 PaTu 8988t C1184(0.95)  LDD1138  [1]
 LDCM0270  AC15 PaTu 8988t C1184(0.88)  LDD1149  [1]
 LDCM0276  AC17 HCT 116 C1540(0.73)  LDD0593  [1]
 LDCM0277  AC18 HCT 116 C1540(1.10)  LDD0594  [1]
 LDCM0278  AC19 HCT 116 C1540(0.86)  LDD0595  [1]
 LDCM0279  AC2 HCT 116 C1540(0.71); C1184(1.25)  LDD0596  [1]
 LDCM0280  AC20 HCT 116 C1540(0.97)  LDD0597  [1]
 LDCM0281  AC21 HCT 116 C1540(0.90)  LDD0598  [1]
 LDCM0282  AC22 HCT 116 C1540(0.98)  LDD0599  [1]
 LDCM0283  AC23 HCT 116 C1540(0.99)  LDD0600  [1]
 LDCM0284  AC24 HCT 116 C1540(0.90)  LDD0601  [1]
 LDCM0285  AC25 HEK-293T C886(0.82); C525(1.35)  LDD1524  [3]
 LDCM0286  AC26 HEK-293T C1184(0.72); C886(0.91); C525(1.26)  LDD1525  [3]
 LDCM0287  AC27 HEK-293T C1184(1.14); C886(0.91); C427(1.01)  LDD1526  [3]
 LDCM0288  AC28 HEK-293T C1184(1.06); C886(0.94); C427(0.78)  LDD1527  [3]
 LDCM0289  AC29 HEK-293T C1184(0.88); C886(1.07); C525(0.90); C427(1.17)  LDD1528  [3]
 LDCM0290  AC3 HCT 116 C1540(0.89); C1184(1.25)  LDD0607  [1]
 LDCM0291  AC30 HEK-293T C373(0.99); C1184(1.02); C886(0.91); C525(1.05)  LDD1530  [3]
 LDCM0292  AC31 HEK-293T C1184(1.08); C886(1.06); C427(0.81)  LDD1531  [3]
 LDCM0293  AC32 HEK-293T C1184(1.11); C886(1.05)  LDD1532  [3]
 LDCM0294  AC33 HEK-293T C886(0.94); C525(1.20)  LDD1533  [3]
 LDCM0295  AC34 HEK-293T C1184(0.77); C886(0.91); C525(0.99)  LDD1534  [3]
 LDCM0296  AC35 HCT 116 C1184(0.99)  LDD0613  [1]
 LDCM0297  AC36 HCT 116 C1184(1.03)  LDD0614  [1]
 LDCM0298  AC37 HCT 116 C1184(0.95)  LDD0615  [1]
 LDCM0299  AC38 HCT 116 C1184(1.04)  LDD0616  [1]
 LDCM0300  AC39 HCT 116 C1184(1.05)  LDD0617  [1]
 LDCM0301  AC4 HCT 116 C1540(0.80); C1184(1.27)  LDD0618  [1]
 LDCM0302  AC40 HCT 116 C1184(0.99)  LDD0619  [1]
 LDCM0303  AC41 HCT 116 C1184(1.01)  LDD0620  [1]
 LDCM0304  AC42 HCT 116 C1184(1.01)  LDD0621  [1]
 LDCM0305  AC43 HCT 116 C1184(1.09)  LDD0622  [1]
 LDCM0306  AC44 HCT 116 C1184(1.09)  LDD0623  [1]
 LDCM0307  AC45 HCT 116 C1184(1.05)  LDD0624  [1]
 LDCM0308  AC46 HCT 116 C1184(0.90)  LDD0625  [1]
 LDCM0309  AC47 HCT 116 C1184(0.94)  LDD0626  [1]
 LDCM0310  AC48 HCT 116 C1184(1.07)  LDD0627  [1]
 LDCM0311  AC49 HCT 116 C1184(1.10)  LDD0628  [1]
 LDCM0312  AC5 HCT 116 C1540(0.93); C1184(1.36)  LDD0629  [1]
 LDCM0313  AC50 HCT 116 C1184(1.03)  LDD0630  [1]
 LDCM0314  AC51 HCT 116 C1184(1.03)  LDD0631  [1]
 LDCM0315  AC52 HCT 116 C1184(1.08)  LDD0632  [1]
 LDCM0316  AC53 HCT 116 C1184(1.01)  LDD0633  [1]
 LDCM0317  AC54 HCT 116 C1184(1.01)  LDD0634  [1]
 LDCM0318  AC55 HCT 116 C1184(1.01)  LDD0635  [1]
 LDCM0319  AC56 HCT 116 C1184(1.07)  LDD0636  [1]
 LDCM0320  AC57 HEK-293T C886(0.81); C525(1.08)  LDD1559  [3]
 LDCM0321  AC58 HEK-293T C1184(0.89); C886(1.12); C525(1.17)  LDD1560  [3]
 LDCM0322  AC59 HEK-293T C1184(0.96); C886(1.01); C427(1.17)  LDD1561  [3]
 LDCM0323  AC6 PaTu 8988t C1184(0.96)  LDD1202  [1]
 LDCM0324  AC60 HEK-293T C1184(0.94); C886(0.86); C427(0.92)  LDD1563  [3]
 LDCM0325  AC61 HEK-293T C1184(0.97); C886(0.96); C525(1.08); C427(0.88)  LDD1564  [3]
 LDCM0326  AC62 HEK-293T C373(0.90); C1184(0.94); C886(1.14); C525(1.37)  LDD1565  [3]
 LDCM0327  AC63 HEK-293T C1184(0.99); C886(1.02); C427(0.76)  LDD1566  [3]
 LDCM0328  AC64 HEK-293T C1184(0.96); C886(1.19)  LDD1567  [3]
 LDCM0332  AC68 HCT 116 C1540(1.11)  LDD0649  [1]
 LDCM0333  AC69 HCT 116 C1540(1.09)  LDD0650  [1]
 LDCM0334  AC7 PaTu 8988t C1184(0.93)  LDD1213  [1]
 LDCM0335  AC70 HCT 116 C1540(1.15)  LDD0652  [1]
 LDCM0336  AC71 HCT 116 C1540(1.16)  LDD0653  [1]
 LDCM0337  AC72 HCT 116 C1540(1.18)  LDD0654  [1]
 LDCM0338  AC73 HCT 116 C1540(1.25)  LDD0655  [1]
 LDCM0339  AC74 HCT 116 C1540(1.27)  LDD0656  [1]
 LDCM0340  AC75 HCT 116 C1540(1.29)  LDD0657  [1]
 LDCM0341  AC76 HCT 116 C1540(1.19)  LDD0658  [1]
 LDCM0342  AC77 HCT 116 C1540(1.16)  LDD0659  [1]
 LDCM0343  AC78 HCT 116 C1540(1.24)  LDD0660  [1]
 LDCM0344  AC79 HCT 116 C1540(1.17)  LDD0661  [1]
 LDCM0345  AC8 PaTu 8988t C1184(0.90)  LDD1224  [1]
 LDCM0346  AC80 HCT 116 C1540(1.13)  LDD0663  [1]
 LDCM0347  AC81 HCT 116 C1540(1.29)  LDD0664  [1]
 LDCM0348  AC82 HCT 116 C1540(1.54)  LDD0665  [1]
 LDCM0349  AC83 HCT 116 C1540(1.29)  LDD0666  [1]
 LDCM0350  AC84 HCT 116 C1540(0.97)  LDD0667  [1]
 LDCM0351  AC85 HCT 116 C1540(1.11)  LDD0668  [1]
 LDCM0352  AC86 HCT 116 C1540(1.23)  LDD0669  [1]
 LDCM0353  AC87 HCT 116 C1540(1.25)  LDD0670  [1]
 LDCM0354  AC88 HCT 116 C1540(1.36)  LDD0671  [1]
 LDCM0355  AC89 HCT 116 C1540(1.42)  LDD0672  [1]
 LDCM0357  AC90 HCT 116 C1540(1.26)  LDD0674  [1]
 LDCM0358  AC91 HCT 116 C1540(1.23)  LDD0675  [1]
 LDCM0359  AC92 HCT 116 C1540(1.04)  LDD0676  [1]
 LDCM0360  AC93 HCT 116 C1540(0.98)  LDD0677  [1]
 LDCM0361  AC94 HCT 116 C1540(1.10)  LDD0678  [1]
 LDCM0362  AC95 HCT 116 C1540(1.34)  LDD0679  [1]
 LDCM0363  AC96 HCT 116 C1540(0.88)  LDD0680  [1]
 LDCM0364  AC97 HCT 116 C1540(1.18)  LDD0681  [1]
 LDCM0248  AKOS034007472 PaTu 8988t C1184(0.85)  LDD1127  [1]
 LDCM0356  AKOS034007680 PaTu 8988t C1184(0.88)  LDD1235  [1]
 LDCM0275  AKOS034007705 PaTu 8988t C1184(0.89)  LDD1154  [1]
 LDCM0367  CL1 PaTu 8988t C1184(0.77)  LDD1246  [1]
 LDCM0368  CL10 PaTu 8988t C1184(0.65)  LDD1247  [1]
 LDCM0369  CL100 HCT 116 C1540(0.66); C1184(1.15)  LDD0686  [1]
 LDCM0370  CL101 PaTu 8988t C1184(0.98)  LDD1249  [1]
 LDCM0371  CL102 PaTu 8988t C1184(0.92)  LDD1250  [1]
 LDCM0372  CL103 PaTu 8988t C1184(0.95)  LDD1251  [1]
 LDCM0373  CL104 PaTu 8988t C1184(0.94)  LDD1252  [1]
 LDCM0374  CL105 HCT 116 C1540(1.22)  LDD0691  [1]
 LDCM0375  CL106 HCT 116 C1540(1.12)  LDD0692  [1]
 LDCM0376  CL107 HCT 116 C1540(1.11)  LDD0693  [1]
 LDCM0377  CL108 HCT 116 C1540(0.93)  LDD0694  [1]
 LDCM0378  CL109 HCT 116 C1540(1.12)  LDD0695  [1]
 LDCM0379  CL11 PaTu 8988t C1184(0.79)  LDD1258  [1]
 LDCM0380  CL110 HCT 116 C1540(1.54)  LDD0697  [1]
 LDCM0381  CL111 HCT 116 C1540(1.49)  LDD0698  [1]
 LDCM0382  CL112 HEK-293T C886(0.92)  LDD1586  [3]
 LDCM0383  CL113 HEK-293T C1184(0.90); C886(1.05); C525(0.85); C427(0.97)  LDD1587  [3]
 LDCM0384  CL114 HEK-293T C1184(0.99); C886(0.81); C525(1.09)  LDD1588  [3]
 LDCM0385  CL115 HEK-293T C1184(0.81); C886(1.22); C525(1.16)  LDD1589  [3]
 LDCM0386  CL116 HEK-293T C886(0.90)  LDD1590  [3]
 LDCM0387  CL117 HCT 116 C1184(1.02)  LDD0704  [1]
 LDCM0388  CL118 HCT 116 C1184(1.06)  LDD0705  [1]
 LDCM0389  CL119 HCT 116 C1184(0.99)  LDD0706  [1]
 LDCM0390  CL12 PaTu 8988t C1184(0.83)  LDD1269  [1]
 LDCM0391  CL120 HCT 116 C1184(1.11)  LDD0708  [1]
 LDCM0392  CL121 HCT 116 C1184(0.76)  LDD0709  [1]
 LDCM0393  CL122 HCT 116 C1184(0.98)  LDD0710  [1]
 LDCM0394  CL123 HCT 116 C1184(0.93)  LDD0711  [1]
 LDCM0395  CL124 HCT 116 C1184(1.01)  LDD0712  [1]
 LDCM0396  CL125 HEK-293T C1184(0.92); C886(0.99); C525(0.89); C427(0.88)  LDD1600  [3]
 LDCM0397  CL126 HEK-293T C1184(0.85); C886(0.99); C525(1.11)  LDD1601  [3]
 LDCM0398  CL127 HEK-293T C1184(0.81); C886(1.13); C525(1.13)  LDD1602  [3]
 LDCM0399  CL128 HEK-293T C886(0.95)  LDD1603  [3]
 LDCM0400  CL13 PaTu 8988t C1184(0.76)  LDD1279  [1]
 LDCM0401  CL14 PaTu 8988t C1184(0.77)  LDD1280  [1]
 LDCM0402  CL15 PaTu 8988t C1184(0.83)  LDD1281  [1]
 LDCM0403  CL16 HCT 116 C1184(0.92)  LDD0720  [1]
 LDCM0404  CL17 HCT 116 C1184(1.09)  LDD0721  [1]
 LDCM0405  CL18 HCT 116 C1184(0.92)  LDD0722  [1]
 LDCM0406  CL19 HCT 116 C1184(0.97)  LDD0723  [1]
 LDCM0407  CL2 PaTu 8988t C1184(0.78)  LDD1286  [1]
 LDCM0408  CL20 HCT 116 C1184(0.90)  LDD0725  [1]
 LDCM0409  CL21 HCT 116 C1184(0.99)  LDD0726  [1]
 LDCM0410  CL22 HCT 116 C1184(0.92)  LDD0727  [1]
 LDCM0411  CL23 HCT 116 C1184(0.92)  LDD0728  [1]
 LDCM0412  CL24 HCT 116 C1184(1.00)  LDD0729  [1]
 LDCM0413  CL25 HCT 116 C1184(0.98)  LDD0730  [1]
 LDCM0414  CL26 HCT 116 C1184(0.97)  LDD0731  [1]
 LDCM0415  CL27 HCT 116 C1184(0.93)  LDD0732  [1]
 LDCM0416  CL28 HCT 116 C1184(0.93)  LDD0733  [1]
 LDCM0417  CL29 HCT 116 C1184(0.99)  LDD0734  [1]
 LDCM0418  CL3 PaTu 8988t C1184(0.76)  LDD1297  [1]
 LDCM0419  CL30 HCT 116 C1184(0.97)  LDD0736  [1]
 LDCM0420  CL31 HCT 116 C1540(1.43)  LDD0737  [1]
 LDCM0421  CL32 HCT 116 C1540(1.32)  LDD0738  [1]
 LDCM0422  CL33 HCT 116 C1540(0.95)  LDD0739  [1]
 LDCM0423  CL34 HCT 116 C1540(1.07)  LDD0740  [1]
 LDCM0424  CL35 HCT 116 C1540(1.00)  LDD0741  [1]
 LDCM0425  CL36 HCT 116 C1540(1.02)  LDD0742  [1]
 LDCM0426  CL37 HCT 116 C1540(1.02)  LDD0743  [1]
 LDCM0428  CL39 HCT 116 C1540(1.21)  LDD0745  [1]
 LDCM0429  CL4 PaTu 8988t C1184(0.78)  LDD1308  [1]
 LDCM0430  CL40 HCT 116 C1540(1.23)  LDD0747  [1]
 LDCM0431  CL41 HCT 116 C1540(0.91)  LDD0748  [1]
 LDCM0432  CL42 HCT 116 C1540(0.96)  LDD0749  [1]
 LDCM0433  CL43 HCT 116 C1540(1.04)  LDD0750  [1]
 LDCM0434  CL44 HCT 116 C1540(1.17)  LDD0751  [1]
 LDCM0435  CL45 HCT 116 C1540(1.47)  LDD0752  [1]
 LDCM0436  CL46 PaTu 8988t C1184(0.96)  LDD1315  [1]
 LDCM0437  CL47 PaTu 8988t C1184(0.87)  LDD1316  [1]
 LDCM0438  CL48 PaTu 8988t C1184(0.93)  LDD1317  [1]
 LDCM0439  CL49 PaTu 8988t C1184(0.90)  LDD1318  [1]
 LDCM0440  CL5 PaTu 8988t C1184(0.82)  LDD1319  [1]
 LDCM0441  CL50 PaTu 8988t C1184(0.90)  LDD1320  [1]
 LDCM0442  CL51 PaTu 8988t C1184(0.90)  LDD1321  [1]
 LDCM0443  CL52 PaTu 8988t C1184(0.95)  LDD1322  [1]
 LDCM0444  CL53 PaTu 8988t C1184(0.95)  LDD1323  [1]
 LDCM0445  CL54 PaTu 8988t C1184(0.79)  LDD1324  [1]
 LDCM0446  CL55 PaTu 8988t C1184(0.85)  LDD1325  [1]
 LDCM0447  CL56 PaTu 8988t C1184(0.25)  LDD1326  [1]
 LDCM0448  CL57 PaTu 8988t C1184(0.99)  LDD1327  [1]
 LDCM0449  CL58 PaTu 8988t C1184(0.95)  LDD1328  [1]
 LDCM0450  CL59 PaTu 8988t C1184(0.91)  LDD1329  [1]
 LDCM0451  CL6 PaTu 8988t C1184(0.79)  LDD1330  [1]
 LDCM0452  CL60 PaTu 8988t C1184(0.88)  LDD1331  [1]
 LDCM0453  CL61 HEK-293T C1184(1.37); C886(0.99); C525(0.88); C427(0.98)  LDD1656  [3]
 LDCM0454  CL62 HEK-293T C1184(1.03); C886(0.90); C525(0.96)  LDD1657  [3]
 LDCM0455  CL63 HEK-293T C1184(0.80); C886(1.11); C525(1.02)  LDD1658  [3]
 LDCM0456  CL64 HEK-293T C886(0.95)  LDD1659  [3]
 LDCM0457  CL65 HEK-293T C886(0.98); C525(1.26)  LDD1660  [3]
 LDCM0458  CL66 HEK-293T C1184(0.81); C886(1.01); C525(1.02)  LDD1661  [3]
 LDCM0459  CL67 HEK-293T C1184(0.91); C886(0.85); C427(1.02)  LDD1662  [3]
 LDCM0460  CL68 HEK-293T C1184(1.06); C886(0.91); C427(0.96)  LDD1663  [3]
 LDCM0461  CL69 HEK-293T C1184(0.98); C886(0.88); C525(1.04); C427(1.06)  LDD1664  [3]
 LDCM0462  CL7 PaTu 8988t C1184(0.87)  LDD1341  [1]
 LDCM0463  CL70 HEK-293T C373(1.31); C1184(0.99); C886(0.94); C525(1.34)  LDD1666  [3]
 LDCM0464  CL71 HEK-293T C1184(1.15); C886(0.98); C427(0.45)  LDD1667  [3]
 LDCM0465  CL72 HEK-293T C1184(1.11); C886(0.91)  LDD1668  [3]
 LDCM0466  CL73 HEK-293T C1184(0.96); C886(1.07); C525(0.84); C427(1.07)  LDD1669  [3]
 LDCM0467  CL74 HEK-293T C1184(1.11); C886(0.94); C525(1.28)  LDD1670  [3]
 LDCM0469  CL76 PaTu 8988t C1184(0.88)  LDD1348  [1]
 LDCM0470  CL77 PaTu 8988t C1184(0.81)  LDD1349  [1]
 LDCM0471  CL78 PaTu 8988t C1184(0.82)  LDD1350  [1]
 LDCM0472  CL79 PaTu 8988t C1184(0.75)  LDD1351  [1]
 LDCM0473  CL8 PaTu 8988t C1184(0.80)  LDD1352  [1]
 LDCM0474  CL80 PaTu 8988t C1184(0.90)  LDD1353  [1]
 LDCM0475  CL81 PaTu 8988t C1184(0.85)  LDD1354  [1]
 LDCM0476  CL82 PaTu 8988t C1184(0.90)  LDD1355  [1]
 LDCM0477  CL83 PaTu 8988t C1184(0.77)  LDD1356  [1]
 LDCM0478  CL84 PaTu 8988t C1184(0.84)  LDD1357  [1]
 LDCM0479  CL85 PaTu 8988t C1184(0.76)  LDD1358  [1]
 LDCM0480  CL86 PaTu 8988t C1184(0.76)  LDD1359  [1]
 LDCM0481  CL87 PaTu 8988t C1184(0.78)  LDD1360  [1]
 LDCM0482  CL88 PaTu 8988t C1184(0.77)  LDD1361  [1]
 LDCM0483  CL89 PaTu 8988t C1184(0.74)  LDD1362  [1]
 LDCM0484  CL9 PaTu 8988t C1184(0.69)  LDD1363  [1]
 LDCM0485  CL90 PaTu 8988t C1184(0.75)  LDD1364  [1]
 LDCM0486  CL91 HCT 116 C1184(0.98); C1540(0.83)  LDD0803  [1]
 LDCM0487  CL92 HCT 116 C1184(1.18); C1540(0.75)  LDD0804  [1]
 LDCM0488  CL93 HCT 116 C1184(1.09); C1540(0.80)  LDD0805  [1]
 LDCM0489  CL94 HCT 116 C1184(1.27); C1540(0.89)  LDD0806  [1]
 LDCM0490  CL95 HCT 116 C1184(1.12); C1540(1.21)  LDD0807  [1]
 LDCM0491  CL96 HCT 116 C1184(1.27); C1540(0.86)  LDD0808  [1]
 LDCM0492  CL97 HCT 116 C1184(1.23); C1540(0.76)  LDD0809  [1]
 LDCM0493  CL98 HCT 116 C1184(1.20); C1540(0.88)  LDD0810  [1]
 LDCM0494  CL99 HCT 116 C1184(1.18); C1540(0.76)  LDD0811  [1]
 LDCM0495  E2913 HEK-293T C1184(0.75); C886(1.10); C525(1.10)  LDD1698  [3]
 LDCM0468  Fragment33 HEK-293T C1184(1.07); C886(1.18); C525(1.03)  LDD1671  [3]
 LDCM0427  Fragment51 HCT 116 C1540(1.17)  LDD0744  [1]
 LDCM0022  KB02 HEK-293T C886(1.08)  LDD1492  [3]
 LDCM0023  KB03 HEK-293T C886(1.06)  LDD1497  [3]
 LDCM0024  KB05 HMCB C1184(1.36)  LDD3312  [4]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Other
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Four and a half LIM domains protein 3 (FHL3) . Q13643
RNA-binding protein with multiple splicing (RBPMS) . Q93062

References

1 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
2 Benchmarking Cleavable Biotin Tags for Peptide-Centric Chemoproteomics. J Proteome Res. 2022 May 6;21(5):1349-1358. doi: 10.1021/acs.jproteome.2c00174. Epub 2022 Apr 25.
Mass spectrometry data entry: PXD031019
3 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
4 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840