Details of the Target

General Information of Target

Target ID LDTP08293
Target Name Vacuolar protein-sorting-associated protein 36 (VPS36)
Gene Name VPS36
Gene ID 51028
Synonyms
C13orf9; EAP45; Vacuolar protein-sorting-associated protein 36; ELL-associated protein of 45 kDa; ESCRT-II complex subunit VPS36
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MDRFVWTSGLLEINETLVIQQRGVRIYDGEEKIKFDAGTLLLSTHRLIWRDQKNHECCMA
ILLSQIVFIEEQAAGIGKSAKIVVHLHPAPPNKEPGPFQSSKNSYIKLSFKEHGQIEFYR
RLSEEMTQRRWENMPVSQSLQTNRGPQPGRIRAVGIVGIERKLEEKRKETDKNISEAFED
LSKLMIKAKEMVELSKSIANKIKDKQGDITEDETIRFKSYLLSMGIANPVTRETYGSGTQ
YHMQLAKQLAGILQVPLEERGGIMSLTEVYCLVNRARGMELLSPEDLVNACKMLEALKLP
LRLRVFDSGVMVIELQSHKEEEMVASALETVSEKGSLTSEEFAKLVGMSVLLAKERLLLA
EKMGHLCRDDSVEGLRFYPNLFMTQS
Target Bioclass
Other
Family
VPS36 family
Subcellular location
Cytoplasm
Function
Component of the ESCRT-II complex (endosomal sorting complex required for transport II), which is required for multivesicular body (MVB) formation and sorting of endosomal cargo proteins into MVBs. The MVB pathway mediates delivery of transmembrane proteins into the lumen of the lysosome for degradation. The ESCRT-II complex is probably involved in the recruitment of the ESCRT-III complex. Its ability to bind ubiquitin probably plays a role in endosomal sorting of ubiquitinated cargo proteins by ESCRT complexes. The ESCRT-II complex may also play a role in transcription regulation, possibly via its interaction with ELL. Binds phosphoinosides such as PtdIns(3,4,5)P3.
Uniprot ID
Q86VN1
Ensemble ID
ENST00000378060.9
HGNC ID
HGNC:20312

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
RKO SNV: p.I106V .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 10 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
TH211
 Probe Info  		Y235(9.32)  LDD0260  [1]
BTD
 Probe Info  		C367(1.26)  LDD2093  [2]
IPM
 Probe Info  		C367(2.00)  LDD1702  [2]
DBIA
 Probe Info  		C291(0.68)  LDD0532  [3]
ATP probe
 Probe Info  		N.A.  LDD0199  [4]
4-Iodoacetamidophenylacetylene
 Probe Info  		C271(0.00); C291(0.00)  LDD0038  [5]
IA-alkyne
 Probe Info  		C291(0.00); C271(0.00); C57(0.00); C58(0.00)  LDD0036  [5]
Lodoacetamide azide
 Probe Info  		C271(0.00); C291(0.00)  LDD0037  [5]
Methacrolein
 Probe Info  		N.A.  LDD0218  [6]
NAIA_5
 Probe Info  		C271(0.00); C367(0.00)  LDD2223  [7]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0524  2-Cyano-N-(2-morpholin-4-yl-ethyl)-acetamide MDA-MB-231 C367(1.07)  LDD2117  [2]
 LDCM0558  2-Cyano-N-phenylacetamide MDA-MB-231 C367(1.21)  LDD2152  [2]
 LDCM0214  AC1 HEK-293T C271(0.97); C291(1.10); C57(0.95)  LDD1507  [8]
 LDCM0215  AC10 HCT 116 C291(0.68)  LDD0532  [3]
 LDCM0216  AC100 HCT 116 C291(1.20)  LDD0533  [3]
 LDCM0217  AC101 HCT 116 C291(1.18)  LDD0534  [3]
 LDCM0218  AC102 HCT 116 C291(1.20)  LDD0535  [3]
 LDCM0219  AC103 HCT 116 C291(1.05)  LDD0536  [3]
 LDCM0220  AC104 HCT 116 C291(1.02)  LDD0537  [3]
 LDCM0221  AC105 HCT 116 C291(1.13)  LDD0538  [3]
 LDCM0222  AC106 HCT 116 C291(1.07)  LDD0539  [3]
 LDCM0223  AC107 HCT 116 C291(1.16)  LDD0540  [3]
 LDCM0224  AC108 HCT 116 C291(1.20)  LDD0541  [3]
 LDCM0225  AC109 HCT 116 C291(0.99)  LDD0542  [3]
 LDCM0226  AC11 HCT 116 C291(0.62)  LDD0543  [3]
 LDCM0227  AC110 HCT 116 C291(1.08)  LDD0544  [3]
 LDCM0228  AC111 HCT 116 C291(1.06)  LDD0545  [3]
 LDCM0229  AC112 HCT 116 C291(0.99)  LDD0546  [3]
 LDCM0230  AC113 PaTu 8988t C271(1.20)  LDD1109  [3]
 LDCM0231  AC114 PaTu 8988t C271(0.90)  LDD1110  [3]
 LDCM0232  AC115 PaTu 8988t C271(1.13)  LDD1111  [3]
 LDCM0233  AC116 PaTu 8988t C271(0.87)  LDD1112  [3]
 LDCM0234  AC117 PaTu 8988t C271(0.96)  LDD1113  [3]
 LDCM0235  AC118 PaTu 8988t C271(1.15)  LDD1114  [3]
 LDCM0236  AC119 PaTu 8988t C271(1.04)  LDD1115  [3]
 LDCM0237  AC12 HCT 116 C291(0.76)  LDD0554  [3]
 LDCM0238  AC120 PaTu 8988t C271(1.10)  LDD1117  [3]
 LDCM0239  AC121 PaTu 8988t C271(1.28)  LDD1118  [3]
 LDCM0240  AC122 PaTu 8988t C271(1.03)  LDD1119  [3]
 LDCM0241  AC123 PaTu 8988t C271(1.11)  LDD1120  [3]
 LDCM0242  AC124 PaTu 8988t C271(1.46)  LDD1121  [3]
 LDCM0243  AC125 PaTu 8988t C271(1.30)  LDD1122  [3]
 LDCM0244  AC126 PaTu 8988t C271(0.79)  LDD1123  [3]
 LDCM0245  AC127 PaTu 8988t C271(0.86)  LDD1124  [3]
 LDCM0246  AC128 HEK-293T C291(1.11)  LDD0844  [3]
 LDCM0247  AC129 HEK-293T C291(1.12)  LDD0845  [3]
 LDCM0249  AC130 HEK-293T C291(1.08)  LDD0847  [3]
 LDCM0250  AC131 HEK-293T C291(1.11)  LDD0848  [3]
 LDCM0251  AC132 HEK-293T C291(1.25)  LDD0849  [3]
 LDCM0252  AC133 HEK-293T C291(1.18)  LDD0850  [3]
 LDCM0253  AC134 HEK-293T C291(1.23)  LDD0851  [3]
 LDCM0254  AC135 HEK-293T C291(1.12)  LDD0852  [3]
 LDCM0255  AC136 HEK-293T C291(1.26)  LDD0853  [3]
 LDCM0256  AC137 HEK-293T C291(1.18)  LDD0854  [3]
 LDCM0257  AC138 HEK-293T C291(1.56)  LDD0855  [3]
 LDCM0258  AC139 HEK-293T C291(1.32)  LDD0856  [3]
 LDCM0259  AC14 HCT 116 C291(0.83)  LDD0576  [3]
 LDCM0260  AC140 HEK-293T C291(1.06)  LDD0858  [3]
 LDCM0261  AC141 HEK-293T C291(1.50)  LDD0859  [3]
 LDCM0262  AC142 HEK-293T C291(1.31)  LDD0860  [3]
 LDCM0263  AC143 HEK-293T C271(1.06)  LDD0861  [3]
 LDCM0264  AC144 HEK-293T C271(0.94)  LDD0862  [3]
 LDCM0265  AC145 HEK-293T C271(1.02)  LDD0863  [3]
 LDCM0266  AC146 HEK-293T C271(1.01)  LDD0864  [3]
 LDCM0267  AC147 HEK-293T C271(1.04)  LDD0865  [3]
 LDCM0268  AC148 HEK-293T C271(1.12)  LDD0866  [3]
 LDCM0269  AC149 HEK-293T C271(0.99)  LDD0867  [3]
 LDCM0270  AC15 HCT 116 C291(0.73)  LDD0587  [3]
 LDCM0271  AC150 HEK-293T C271(1.00)  LDD0869  [3]
 LDCM0272  AC151 HEK-293T C271(0.95)  LDD0870  [3]
 LDCM0273  AC152 HEK-293T C271(1.00)  LDD0871  [3]
 LDCM0274  AC153 HEK-293T C271(1.04)  LDD0872  [3]
 LDCM0621  AC154 HEK-293T C271(0.96)  LDD2162  [3]
 LDCM0622  AC155 HEK-293T C271(1.01)  LDD2163  [3]
 LDCM0623  AC156 HEK-293T C271(1.24)  LDD2164  [3]
 LDCM0624  AC157 HEK-293T C271(1.32)  LDD2165  [3]
 LDCM0276  AC17 HEK-293T C271(1.00); C291(0.93); C57(0.91)  LDD1515  [8]
 LDCM0277  AC18 HEK-293T C271(1.07); C291(0.94); C57(1.00)  LDD1516  [8]
 LDCM0278  AC19 HEK-293T C271(0.82); C57(0.90)  LDD1517  [8]
 LDCM0279  AC2 HEK-293T C271(1.07); C291(0.97); C57(1.00)  LDD1518  [8]
 LDCM0280  AC20 HEK-293T C271(1.01); C291(1.05); C57(1.01)  LDD1519  [8]
 LDCM0281  AC21 HEK-293T C271(1.03); C291(1.02)  LDD1520  [8]
 LDCM0282  AC22 HEK-293T C271(0.97); C291(1.05); C57(1.09)  LDD1521  [8]
 LDCM0283  AC23 HEK-293T C271(0.96); C291(0.96); C57(0.92)  LDD1522  [8]
 LDCM0284  AC24 HEK-293T C271(0.99); C291(1.01)  LDD1523  [8]
 LDCM0285  AC25 PaTu 8988t C271(0.86); C291(0.91); C57(1.16); C58(1.16)  LDD1164  [3]
 LDCM0286  AC26 PaTu 8988t C271(0.75); C291(0.93); C57(0.97); C58(0.97)  LDD1165  [3]
 LDCM0287  AC27 PaTu 8988t C271(1.01); C291(0.80); C57(1.12); C58(1.12)  LDD1166  [3]
 LDCM0288  AC28 PaTu 8988t C271(0.91); C291(0.77); C57(1.07); C58(1.07)  LDD1167  [3]
 LDCM0289  AC29 PaTu 8988t C271(0.66); C291(0.79); C57(1.23); C58(1.23)  LDD1168  [3]
 LDCM0290  AC3 HEK-293T C271(1.21); C57(1.03)  LDD1529  [8]
 LDCM0291  AC30 PaTu 8988t C271(0.82); C291(1.11); C57(1.08); C58(1.08)  LDD1170  [3]
 LDCM0292  AC31 PaTu 8988t C271(0.91); C291(1.22); C57(1.12); C58(1.12)  LDD1171  [3]
 LDCM0293  AC32 PaTu 8988t C271(0.92); C291(0.99); C57(0.98); C58(0.98)  LDD1172  [3]
 LDCM0294  AC33 PaTu 8988t C271(0.98); C291(0.77); C57(1.02); C58(1.02)  LDD1173  [3]
 LDCM0295  AC34 PaTu 8988t C271(0.76); C291(0.81); C57(1.16); C58(1.16)  LDD1174  [3]
 LDCM0296  AC35 HCT 116 C291(0.82)  LDD0613  [3]
 LDCM0297  AC36 HCT 116 C291(0.99)  LDD0614  [3]
 LDCM0298  AC37 HCT 116 C291(1.06)  LDD0615  [3]
 LDCM0299  AC38 HCT 116 C291(0.92)  LDD0616  [3]
 LDCM0300  AC39 HCT 116 C291(1.04)  LDD0617  [3]
 LDCM0301  AC4 HEK-293T C271(1.06); C291(1.03); C57(0.98)  LDD1540  [8]
 LDCM0302  AC40 HCT 116 C291(1.22)  LDD0619  [3]
 LDCM0303  AC41 HCT 116 C291(0.93)  LDD0620  [3]
 LDCM0304  AC42 HCT 116 C291(0.97)  LDD0621  [3]
 LDCM0305  AC43 HCT 116 C291(0.92)  LDD0622  [3]
 LDCM0306  AC44 HCT 116 C291(0.93)  LDD0623  [3]
 LDCM0307  AC45 HCT 116 C291(0.89)  LDD0624  [3]
 LDCM0308  AC46 HCT 116 C291(0.87)  LDD0625  [3]
 LDCM0309  AC47 HCT 116 C291(0.89)  LDD0626  [3]
 LDCM0310  AC48 HCT 116 C291(0.91)  LDD0627  [3]
 LDCM0311  AC49 HCT 116 C291(0.86)  LDD0628  [3]
 LDCM0312  AC5 HEK-293T C271(1.17); C291(1.09)  LDD1551  [8]
 LDCM0313  AC50 HCT 116 C291(0.85)  LDD0630  [3]
 LDCM0314  AC51 HCT 116 C291(1.18)  LDD0631  [3]
 LDCM0315  AC52 HCT 116 C291(0.93)  LDD0632  [3]
 LDCM0316  AC53 HCT 116 C291(0.85)  LDD0633  [3]
 LDCM0317  AC54 HCT 116 C291(0.99)  LDD0634  [3]
 LDCM0318  AC55 HCT 116 C291(0.91)  LDD0635  [3]
 LDCM0319  AC56 HCT 116 C291(0.88)  LDD0636  [3]
 LDCM0320  AC57 HEK-293T C271(1.05); C291(0.96); C57(0.86)  LDD1559  [8]
 LDCM0321  AC58 HEK-293T C271(1.17); C291(0.98); C57(1.00)  LDD1560  [8]
 LDCM0322  AC59 HEK-293T C271(0.99); C57(1.05)  LDD1561  [8]
 LDCM0323  AC6 HCT 116 C291(0.78)  LDD0640  [3]
 LDCM0324  AC60 HEK-293T C271(0.97); C291(1.03); C57(1.10)  LDD1563  [8]
 LDCM0325  AC61 HEK-293T C271(1.07); C291(1.07)  LDD1564  [8]
 LDCM0326  AC62 HEK-293T C271(1.12); C291(0.99); C57(1.06)  LDD1565  [8]
 LDCM0327  AC63 HEK-293T C271(0.99); C291(1.00); C57(0.95)  LDD1566  [8]
 LDCM0328  AC64 HEK-293T C271(1.01); C291(1.01)  LDD1567  [8]
 LDCM0332  AC68 HEK-293T C271(0.86); C291(1.20)  LDD0930  [3]
 LDCM0333  AC69 HEK-293T C271(0.98); C291(1.26)  LDD0931  [3]
 LDCM0334  AC7 HCT 116 C291(0.69)  LDD0651  [3]
 LDCM0335  AC70 HEK-293T C271(0.92); C291(1.09)  LDD0933  [3]
 LDCM0336  AC71 HEK-293T C271(1.10); C291(1.21)  LDD0934  [3]
 LDCM0337  AC72 HEK-293T C271(1.01); C291(1.29)  LDD0935  [3]
 LDCM0338  AC73 HEK-293T C271(0.88); C291(1.24)  LDD0936  [3]
 LDCM0339  AC74 HEK-293T C271(0.97); C291(1.26)  LDD0937  [3]
 LDCM0340  AC75 HEK-293T C271(0.87); C291(1.26)  LDD0938  [3]
 LDCM0341  AC76 HEK-293T C271(0.95); C291(1.14)  LDD0939  [3]
 LDCM0342  AC77 HEK-293T C271(0.94); C291(1.21)  LDD0940  [3]
 LDCM0343  AC78 HEK-293T C271(0.80); C291(1.13)  LDD0941  [3]
 LDCM0344  AC79 HEK-293T C271(0.97); C291(1.32)  LDD0942  [3]
 LDCM0345  AC8 HCT 116 C291(0.77)  LDD0662  [3]
 LDCM0346  AC80 HEK-293T C271(0.90); C291(1.30)  LDD0944  [3]
 LDCM0347  AC81 HEK-293T C271(0.82); C291(1.27)  LDD0945  [3]
 LDCM0348  AC82 HEK-293T C271(0.78); C291(1.53)  LDD0946  [3]
 LDCM0349  AC83 HEK-293T C291(0.92)  LDD0947  [3]
 LDCM0350  AC84 HEK-293T C291(1.09)  LDD0948  [3]
 LDCM0351  AC85 HEK-293T C291(1.03)  LDD0949  [3]
 LDCM0352  AC86 HEK-293T C291(1.07)  LDD0950  [3]
 LDCM0353  AC87 HEK-293T C291(1.28)  LDD0951  [3]
 LDCM0354  AC88 HEK-293T C291(1.20)  LDD0952  [3]
 LDCM0355  AC89 HEK-293T C291(1.36)  LDD0953  [3]
 LDCM0357  AC90 HEK-293T C291(1.01)  LDD0955  [3]
 LDCM0358  AC91 HEK-293T C291(1.00)  LDD0956  [3]
 LDCM0359  AC92 HEK-293T C291(0.97)  LDD0957  [3]
 LDCM0360  AC93 HEK-293T C291(1.03)  LDD0958  [3]
 LDCM0361  AC94 HEK-293T C291(0.97)  LDD0959  [3]
 LDCM0362  AC95 HEK-293T C291(1.14)  LDD0960  [3]
 LDCM0363  AC96 HEK-293T C291(1.07)  LDD0961  [3]
 LDCM0364  AC97 HEK-293T C291(1.36)  LDD0962  [3]
 LDCM0365  AC98 HCT 116 C291(1.01)  LDD0682  [3]
 LDCM0366  AC99 HCT 116 C291(1.10)  LDD0683  [3]
 LDCM0248  AKOS034007472 HCT 116 C291(0.86)  LDD0565  [3]
 LDCM0356  AKOS034007680 HCT 116 C291(0.72)  LDD0673  [3]
 LDCM0275  AKOS034007705 HCT 116 C291(0.67)  LDD0592  [3]
 LDCM0367  CL1 PaTu 8988t C291(0.97)  LDD1246  [3]
 LDCM0368  CL10 PaTu 8988t C291(1.00)  LDD1247  [3]
 LDCM0369  CL100 HEK-293T C271(1.10); C291(1.02); C57(1.05)  LDD1573  [8]
 LDCM0370  CL101 HCT 116 C291(0.82)  LDD0687  [3]
 LDCM0371  CL102 HCT 116 C291(0.80)  LDD0688  [3]
 LDCM0372  CL103 HCT 116 C291(0.89)  LDD0689  [3]
 LDCM0373  CL104 HCT 116 C291(0.80)  LDD0690  [3]
 LDCM0374  CL105 HEK-293T C271(0.91); C291(1.01); C57(0.99)  LDD1578  [8]
 LDCM0375  CL106 HEK-293T C271(1.03); C291(1.02); C57(0.93)  LDD1579  [8]
 LDCM0376  CL107 HEK-293T C271(1.11); C291(1.07); C57(1.09)  LDD1580  [8]
 LDCM0377  CL108 HEK-293T C271(1.00); C291(1.03); C57(1.19)  LDD1581  [8]
 LDCM0378  CL109 HEK-293T C271(0.99); C291(1.10); C57(0.91)  LDD1582  [8]
 LDCM0379  CL11 PaTu 8988t C291(0.94)  LDD1258  [3]
 LDCM0380  CL110 HEK-293T C271(1.00); C291(1.05); C57(1.02)  LDD1584  [8]
 LDCM0381  CL111 HEK-293T C271(0.99); C291(1.02); C57(0.95)  LDD1585  [8]
 LDCM0382  CL112 PaTu 8988t C271(0.83); C291(0.93); C57(0.89); C58(0.89)  LDD1261  [3]
 LDCM0383  CL113 PaTu 8988t C271(1.49); C291(0.94); C57(1.05); C58(1.05)  LDD1262  [3]
 LDCM0384  CL114 PaTu 8988t C271(0.98); C291(0.78); C57(1.05); C58(1.05)  LDD1263  [3]
 LDCM0385  CL115 PaTu 8988t C271(0.72); C291(0.96); C57(1.18); C58(1.18)  LDD1264  [3]
 LDCM0386  CL116 PaTu 8988t C271(0.86); C291(0.77); C57(0.71); C58(0.71)  LDD1265  [3]
 LDCM0387  CL117 HCT 116 C291(0.87)  LDD0704  [3]
 LDCM0388  CL118 HCT 116 C291(0.77)  LDD0705  [3]
 LDCM0389  CL119 HCT 116 C291(0.80)  LDD0706  [3]
 LDCM0390  CL12 PaTu 8988t C291(0.90)  LDD1269  [3]
 LDCM0391  CL120 HCT 116 C291(1.04)  LDD0708  [3]
 LDCM0392  CL121 HCT 116 C291(0.90)  LDD0709  [3]
 LDCM0393  CL122 HCT 116 C291(0.97)  LDD0710  [3]
 LDCM0394  CL123 HCT 116 C291(0.92)  LDD0711  [3]
 LDCM0395  CL124 HCT 116 C291(0.97)  LDD0712  [3]
 LDCM0396  CL125 HEK-293T C271(1.02); C291(1.04); C57(1.11)  LDD1600  [8]
 LDCM0397  CL126 HEK-293T C271(0.99); C291(1.06); C57(0.94)  LDD1601  [8]
 LDCM0398  CL127 HEK-293T C271(1.04); C291(1.07); C57(1.01)  LDD1602  [8]
 LDCM0399  CL128 HEK-293T C271(1.15); C291(1.05); C57(1.08)  LDD1603  [8]
 LDCM0400  CL13 PaTu 8988t C291(0.96)  LDD1279  [3]
 LDCM0401  CL14 PaTu 8988t C291(0.96)  LDD1280  [3]
 LDCM0402  CL15 PaTu 8988t C291(1.00)  LDD1281  [3]
 LDCM0403  CL16 HEK-293T C271(0.95); C291(0.94)  LDD1001  [3]
 LDCM0404  CL17 HEK-293T C271(1.08); C291(0.86)  LDD1002  [3]
 LDCM0405  CL18 HEK-293T C271(0.78); C291(1.00)  LDD1003  [3]
 LDCM0406  CL19 HEK-293T C271(0.94); C291(0.98)  LDD1004  [3]
 LDCM0407  CL2 PaTu 8988t C291(0.92)  LDD1286  [3]
 LDCM0408  CL20 HEK-293T C271(1.01); C291(0.90)  LDD1006  [3]
 LDCM0409  CL21 HEK-293T C271(0.97); C291(1.02)  LDD1007  [3]
 LDCM0410  CL22 HEK-293T C271(0.89); C291(0.85)  LDD1008  [3]
 LDCM0411  CL23 HEK-293T C271(0.93); C291(0.80)  LDD1009  [3]
 LDCM0412  CL24 HEK-293T C271(1.30); C291(0.89)  LDD1010  [3]
 LDCM0413  CL25 HEK-293T C271(1.01); C291(0.94)  LDD1011  [3]
 LDCM0414  CL26 HEK-293T C271(0.91); C291(0.86)  LDD1012  [3]
 LDCM0415  CL27 HEK-293T C271(0.96); C291(0.88)  LDD1013  [3]
 LDCM0416  CL28 HEK-293T C271(1.02); C291(0.91)  LDD1014  [3]
 LDCM0417  CL29 HEK-293T C271(1.13); C291(0.91)  LDD1015  [3]
 LDCM0418  CL3 PaTu 8988t C291(1.05)  LDD1297  [3]
 LDCM0419  CL30 HEK-293T C271(1.03); C291(1.01)  LDD1017  [3]
 LDCM0420  CL31 PaTu 8988t C271(0.99); C291(1.00)  LDD1299  [3]
 LDCM0421  CL32 PaTu 8988t C271(0.97); C291(0.83)  LDD1300  [3]
 LDCM0422  CL33 PaTu 8988t C271(1.59); C291(0.77)  LDD1301  [3]
 LDCM0423  CL34 PaTu 8988t C271(1.16); C291(0.82)  LDD1302  [3]
 LDCM0424  CL35 PaTu 8988t C271(1.24); C291(0.78)  LDD1303  [3]
 LDCM0425  CL36 PaTu 8988t C271(0.41); C291(0.22)  LDD1304  [3]
 LDCM0426  CL37 PaTu 8988t C271(0.82); C291(0.72)  LDD1305  [3]
 LDCM0428  CL39 PaTu 8988t C271(1.20); C291(0.80)  LDD1307  [3]
 LDCM0429  CL4 PaTu 8988t C291(0.99)  LDD1308  [3]
 LDCM0430  CL40 PaTu 8988t C271(1.12); C291(0.83)  LDD1309  [3]
 LDCM0431  CL41 PaTu 8988t C271(1.05); C291(0.85)  LDD1310  [3]
 LDCM0432  CL42 PaTu 8988t C271(1.02); C291(0.84)  LDD1311  [3]
 LDCM0433  CL43 PaTu 8988t C271(1.20); C291(0.69)  LDD1312  [3]
 LDCM0434  CL44 PaTu 8988t C271(1.15); C291(0.69)  LDD1313  [3]
 LDCM0435  CL45 PaTu 8988t C271(1.07); C291(0.72)  LDD1314  [3]
 LDCM0436  CL46 HEK-293T C271(0.77); C291(0.91)  LDD1034  [3]
 LDCM0437  CL47 HEK-293T C271(0.91); C291(0.74)  LDD1035  [3]
 LDCM0438  CL48 HEK-293T C271(0.89); C291(0.92)  LDD1036  [3]
 LDCM0439  CL49 HEK-293T C271(1.14); C291(0.95)  LDD1037  [3]
 LDCM0440  CL5 PaTu 8988t C291(0.94)  LDD1319  [3]
 LDCM0441  CL50 HEK-293T C271(1.04); C291(1.18)  LDD1039  [3]
 LDCM0442  CL51 HEK-293T C271(1.00); C291(0.92)  LDD1040  [3]
 LDCM0443  CL52 HEK-293T C271(0.97); C291(0.90)  LDD1041  [3]
 LDCM0444  CL53 HEK-293T C271(1.01); C291(0.93)  LDD1042  [3]
 LDCM0445  CL54 HEK-293T C271(1.01); C291(0.96)  LDD1043  [3]
 LDCM0446  CL55 HEK-293T C271(0.83); C291(0.94)  LDD1044  [3]
 LDCM0447  CL56 HEK-293T C271(0.97); C291(0.74)  LDD1045  [3]
 LDCM0448  CL57 HEK-293T C271(0.99); C291(1.02)  LDD1046  [3]
 LDCM0449  CL58 HEK-293T C271(1.02); C291(0.98)  LDD1047  [3]
 LDCM0450  CL59 HEK-293T C271(0.89); C291(0.90)  LDD1048  [3]
 LDCM0451  CL6 PaTu 8988t C291(0.80)  LDD1330  [3]
 LDCM0452  CL60 HEK-293T C271(1.12); C291(1.00)  LDD1050  [3]
 LDCM0453  CL61 HCT 116 C291(0.82)  LDD0770  [3]
 LDCM0454  CL62 HCT 116 C291(0.75)  LDD0771  [3]
 LDCM0455  CL63 HCT 116 C291(0.75)  LDD0772  [3]
 LDCM0456  CL64 HCT 116 C291(0.65)  LDD0773  [3]
 LDCM0457  CL65 HCT 116 C291(0.82)  LDD0774  [3]
 LDCM0458  CL66 HCT 116 C291(0.69)  LDD0775  [3]
 LDCM0459  CL67 HCT 116 C291(0.72)  LDD0776  [3]
 LDCM0460  CL68 HCT 116 C291(0.61)  LDD0777  [3]
 LDCM0461  CL69 HCT 116 C291(0.77)  LDD0778  [3]
 LDCM0462  CL7 PaTu 8988t C291(1.12)  LDD1341  [3]
 LDCM0463  CL70 HCT 116 C291(0.61)  LDD0780  [3]
 LDCM0464  CL71 HCT 116 C291(0.72)  LDD0781  [3]
 LDCM0465  CL72 HCT 116 C291(1.09)  LDD0782  [3]
 LDCM0466  CL73 HCT 116 C291(0.72)  LDD0783  [3]
 LDCM0467  CL74 HCT 116 C291(0.69)  LDD0784  [3]
 LDCM0469  CL76 PaTu 8988t C271(1.01)  LDD1348  [3]
 LDCM0470  CL77 PaTu 8988t C271(1.05)  LDD1349  [3]
 LDCM0471  CL78 PaTu 8988t C271(1.00)  LDD1350  [3]
 LDCM0472  CL79 PaTu 8988t C271(0.91)  LDD1351  [3]
 LDCM0473  CL8 PaTu 8988t C291(0.84)  LDD1352  [3]
 LDCM0474  CL80 PaTu 8988t C271(0.95)  LDD1353  [3]
 LDCM0475  CL81 PaTu 8988t C271(1.02)  LDD1354  [3]
 LDCM0476  CL82 PaTu 8988t C271(0.70)  LDD1355  [3]
 LDCM0477  CL83 PaTu 8988t C271(0.71)  LDD1356  [3]
 LDCM0478  CL84 PaTu 8988t C271(1.11)  LDD1357  [3]
 LDCM0479  CL85 PaTu 8988t C271(1.32)  LDD1358  [3]
 LDCM0480  CL86 PaTu 8988t C271(1.25)  LDD1359  [3]
 LDCM0481  CL87 PaTu 8988t C271(1.15)  LDD1360  [3]
 LDCM0482  CL88 PaTu 8988t C271(1.16)  LDD1361  [3]
 LDCM0483  CL89 PaTu 8988t C271(1.22)  LDD1362  [3]
 LDCM0484  CL9 PaTu 8988t C291(0.91)  LDD1363  [3]
 LDCM0485  CL90 PaTu 8988t C271(1.38)  LDD1364  [3]
 LDCM0486  CL91 HEK-293T C271(1.05); C57(1.08)  LDD1689  [8]
 LDCM0487  CL92 HEK-293T C271(0.73); C291(1.09); C57(0.97)  LDD1690  [8]
 LDCM0488  CL93 HEK-293T C271(0.94); C291(1.05)  LDD1691  [8]
 LDCM0489  CL94 HEK-293T C271(1.00); C291(0.94); C57(1.14)  LDD1692  [8]
 LDCM0490  CL95 HEK-293T C271(0.89); C291(0.99); C57(0.82)  LDD1693  [8]
 LDCM0491  CL96 HEK-293T C271(1.08); C291(1.02)  LDD1694  [8]
 LDCM0492  CL97 HEK-293T C271(0.94); C291(0.98); C57(0.83)  LDD1695  [8]
 LDCM0493  CL98 HEK-293T C271(0.96); C291(1.13); C57(0.93)  LDD1696  [8]
 LDCM0494  CL99 HEK-293T C271(0.97); C291(1.02); C57(0.98)  LDD1697  [8]
 LDCM0495  E2913 HEK-293T C271(0.93); C291(1.08); C57(1.20)  LDD1698  [8]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C367(2.00)  LDD1702  [2]
 LDCM0468  Fragment33 HCT 116 C291(0.73)  LDD0785  [3]
 LDCM0427  Fragment51 PaTu 8988t C271(1.00); C291(0.72)  LDD1306  [3]
 LDCM0022  KB02 HEK-293T C291(0.95); C271(1.06)  LDD1492  [8]
 LDCM0023  KB03 HEK-293T C291(1.06); C271(0.88)  LDD1497  [8]
 LDCM0024  KB05 HMCB C367(2.50)  LDD3312  [9]
 LDCM0500  Nucleophilic fragment 13a MDA-MB-231 C367(1.26)  LDD2093  [2]
 LDCM0516  Nucleophilic fragment 21a MDA-MB-231 C367(0.72)  LDD2109  [2]
 LDCM0518  Nucleophilic fragment 22a MDA-MB-231 C367(1.17)  LDD2111  [2]
 LDCM0526  Nucleophilic fragment 26a MDA-MB-231 C367(1.39)  LDD2119  [2]
 LDCM0536  Nucleophilic fragment 31 MDA-MB-231 C367(1.45)  LDD2129  [2]
 LDCM0546  Nucleophilic fragment 40 MDA-MB-231 C367(0.88)  LDD2140  [2]
 LDCM0552  Nucleophilic fragment 6a MDA-MB-231 C367(1.08)  LDD2146  [2]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Other
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Vacuolar-sorting protein SNF8 (SNF8) SNF8 family Q96H20
Vacuolar protein-sorting-associated protein 25 (VPS25) VPS25 family Q9BRG1

References

1 Chemoproteomic profiling of kinases in live cells using electrophilic sulfonyl triazole probes. Chem Sci. 2021 Jan 21;12(9):3295-3307. doi: 10.1039/d0sc06623k.
2 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
3 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
4 Targeted Proteomic Approaches for Proteome-Wide Characterizations of the AMP-Binding Capacities of Kinases. J Proteome Res. 2022 Aug 5;21(8):2063-2070. doi: 10.1021/acs.jproteome.2c00225. Epub 2022 Jul 12.
5 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
6 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
7 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
8 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
9 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840