Details of the Target

General Information of Target

Target ID LDTP08124
Target Name E3 ubiquitin-protein ligase E3D (UBE3D)
Gene Name UBE3D
Gene ID 90025
Synonyms
C6orf157; H10BH; UBE2CBP; E3 ubiquitin-protein ligase E3D; EC 2.3.2.26; HECT-type E3 ubiquitin transferase E3D; UbcH10-binding protein with a HECT-like domain; Ubiquitin-conjugating enzyme E2C-binding protein
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MAASAAETRVFLEVRGQLQSALLILGEPKEGGMPMNISIMPSSLQMKTPEGCTEIQLPAE
VRLVPSSCRGLQFVVGDGLHLRLQTQAKLGTKLISMFNQSSQTQECCTFYCQSCGEVIIK
DRKLLRVLPLPSENWGALVGEWCCHPDPFANKSLHPQENDCFIGDSFFLVNLRTSLWQQR
PELSPVEMCCVSSDNHCKLEPKANTKVICKRCKVMLGETVSSETTKFYMTEIIIQSSERS
FPIIPRSWFVQSVIAQCLVQLSSARSTFRFTIQGQDDKVYILLWLLNSDSLVIESLRNSK
YIKKFPLLENTFKADSSSAWSAVKVLYQPCIKSRNEKLVSLWESDISVHPLTLPSATCLE
LLLILSKSNANLPSSLRRVNSFQVAFLKM
Target Bioclass
Enzyme
Subcellular location
Cytoplasm
Function E3 ubiquitin-protein ligase which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes, and transfers it to substrates, generally promoting their degradation by the proteasome.
Uniprot ID
Q7Z6J8
Ensemble ID
ENST00000369747.8
HGNC ID
HGNC:21381

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 6 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
Acrolein
 Probe Info  		N.A.  LDD0222  [1]
DBIA
 Probe Info  		C189(1.12); C190(1.12); C197(1.12)  LDD0078  [2]
IA-alkyne
 Probe Info  		C161(0.00); C330(0.00); C52(0.00)  LDD0165  [3]
NAIA_5
 Probe Info  		N.A.  LDD2225  [4]
IPM
 Probe Info  		C52(0.00); C143(0.00)  LDD2156  [5]
AOyne
 Probe Info  		14.40  LDD0443  [6]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HCT 116 C143(0.99); C144(0.99)  LDD0531  [2]
 LDCM0215  AC10 PaTu 8988t C144(1.51); C143(1.51)  LDD1094  [2]
 LDCM0216  AC100 HEK-293T C143(0.92)  LDD0814  [2]
 LDCM0217  AC101 HEK-293T C143(0.97)  LDD0815  [2]
 LDCM0218  AC102 HEK-293T C143(0.90)  LDD0816  [2]
 LDCM0219  AC103 HEK-293T C143(0.81)  LDD0817  [2]
 LDCM0220  AC104 HEK-293T C143(0.73)  LDD0818  [2]
 LDCM0221  AC105 HEK-293T C143(0.97)  LDD0819  [2]
 LDCM0222  AC106 HEK-293T C143(0.83)  LDD0820  [2]
 LDCM0223  AC107 HEK-293T C143(0.84)  LDD0821  [2]
 LDCM0224  AC108 HEK-293T C143(1.02)  LDD0822  [2]
 LDCM0225  AC109 HEK-293T C143(0.77)  LDD0823  [2]
 LDCM0226  AC11 PaTu 8988t C144(1.50); C143(1.50)  LDD1105  [2]
 LDCM0227  AC110 HEK-293T C143(0.45)  LDD0825  [2]
 LDCM0228  AC111 HEK-293T C143(0.27)  LDD0826  [2]
 LDCM0229  AC112 HEK-293T C143(0.32)  LDD0827  [2]
 LDCM0230  AC113 HEK-293T C143(1.02); C330(0.99)  LDD0828  [2]
 LDCM0231  AC114 HEK-293T C143(0.88); C330(0.95)  LDD0829  [2]
 LDCM0232  AC115 HEK-293T C143(0.99); C330(1.12)  LDD0830  [2]
 LDCM0233  AC116 HEK-293T C143(1.12); C330(1.36)  LDD0831  [2]
 LDCM0234  AC117 HEK-293T C143(1.01); C330(1.01)  LDD0832  [2]
 LDCM0235  AC118 HEK-293T C143(1.09); C330(1.46)  LDD0833  [2]
 LDCM0236  AC119 HEK-293T C143(0.88); C330(1.06)  LDD0834  [2]
 LDCM0237  AC12 PaTu 8988t C144(1.70); C143(1.70)  LDD1116  [2]
 LDCM0238  AC120 HEK-293T C143(1.06); C330(1.00)  LDD0836  [2]
 LDCM0239  AC121 HEK-293T C143(1.09); C330(1.02)  LDD0837  [2]
 LDCM0240  AC122 HEK-293T C143(0.70); C330(0.93)  LDD0838  [2]
 LDCM0241  AC123 HEK-293T C143(0.73); C330(1.01)  LDD0839  [2]
 LDCM0242  AC124 HEK-293T C143(0.97); C330(0.97)  LDD0840  [2]
 LDCM0243  AC125 HEK-293T C143(0.74); C330(1.09)  LDD0841  [2]
 LDCM0244  AC126 HEK-293T C143(0.39); C330(1.03)  LDD0842  [2]
 LDCM0245  AC127 HEK-293T C143(0.31); C330(1.06)  LDD0843  [2]
 LDCM0246  AC128 HEK-293T C143(1.01)  LDD0844  [2]
 LDCM0247  AC129 HEK-293T C143(0.92)  LDD0845  [2]
 LDCM0249  AC130 HEK-293T C143(1.00)  LDD0847  [2]
 LDCM0250  AC131 HEK-293T C143(0.95)  LDD0848  [2]
 LDCM0251  AC132 HEK-293T C143(0.90)  LDD0849  [2]
 LDCM0252  AC133 HEK-293T C143(0.84)  LDD0850  [2]
 LDCM0253  AC134 HEK-293T C143(0.87)  LDD0851  [2]
 LDCM0254  AC135 HEK-293T C143(0.83)  LDD0852  [2]
 LDCM0255  AC136 HEK-293T C143(0.93)  LDD0853  [2]
 LDCM0256  AC137 HEK-293T C143(0.65)  LDD0854  [2]
 LDCM0257  AC138 HEK-293T C143(0.54)  LDD0855  [2]
 LDCM0258  AC139 HEK-293T C143(0.62)  LDD0856  [2]
 LDCM0259  AC14 PaTu 8988t C144(1.50); C143(1.50)  LDD1138  [2]
 LDCM0260  AC140 HEK-293T C143(0.82)  LDD0858  [2]
 LDCM0261  AC141 HEK-293T C143(0.65)  LDD0859  [2]
 LDCM0262  AC142 HEK-293T C143(0.82)  LDD0860  [2]
 LDCM0263  AC143 PaTu 8988t C144(0.69); C143(0.69)  LDD1142  [2]
 LDCM0264  AC144 PaTu 8988t C144(0.67); C143(0.67)  LDD1143  [2]
 LDCM0265  AC145 PaTu 8988t C144(0.70); C143(0.70)  LDD1144  [2]
 LDCM0266  AC146 PaTu 8988t C144(0.49); C143(0.49)  LDD1145  [2]
 LDCM0267  AC147 PaTu 8988t C144(0.45); C143(0.45)  LDD1146  [2]
 LDCM0268  AC148 PaTu 8988t C144(0.73); C143(0.73)  LDD1147  [2]
 LDCM0269  AC149 PaTu 8988t C144(0.70); C143(0.70)  LDD1148  [2]
 LDCM0270  AC15 PaTu 8988t C144(1.27); C143(1.27)  LDD1149  [2]
 LDCM0271  AC150 PaTu 8988t C144(0.67); C143(0.67)  LDD1150  [2]
 LDCM0272  AC151 PaTu 8988t C144(0.67); C143(0.67)  LDD1151  [2]
 LDCM0273  AC152 PaTu 8988t C144(0.54); C143(0.54)  LDD1152  [2]
 LDCM0274  AC153 PaTu 8988t C144(0.59); C143(0.59)  LDD1153  [2]
 LDCM0621  AC154 PaTu 8988t C144(0.66); C143(0.66)  LDD2166  [2]
 LDCM0622  AC155 PaTu 8988t C144(0.59); C143(0.59)  LDD2167  [2]
 LDCM0623  AC156 PaTu 8988t C144(0.71); C143(0.71)  LDD2168  [2]
 LDCM0624  AC157 PaTu 8988t C144(0.50); C143(0.50)  LDD2169  [2]
 LDCM0276  AC17 HCT 116 C143(0.93); C144(0.93)  LDD0593  [2]
 LDCM0277  AC18 HCT 116 C143(1.23); C144(1.23)  LDD0594  [2]
 LDCM0278  AC19 HCT 116 C143(1.18); C144(1.18)  LDD0595  [2]
 LDCM0279  AC2 HCT 116 C143(0.95); C144(0.95)  LDD0596  [2]
 LDCM0280  AC20 HCT 116 C143(0.97); C144(0.97)  LDD0597  [2]
 LDCM0281  AC21 HCT 116 C143(0.95); C144(0.95)  LDD0598  [2]
 LDCM0282  AC22 HCT 116 C143(0.76); C144(0.76)  LDD0599  [2]
 LDCM0283  AC23 HCT 116 C143(1.13); C144(1.13)  LDD0600  [2]
 LDCM0284  AC24 HCT 116 C143(1.06); C144(1.06)  LDD0601  [2]
 LDCM0285  AC25 HEK-293T C143(1.15)  LDD0883  [2]
 LDCM0286  AC26 HEK-293T C143(0.96)  LDD0884  [2]
 LDCM0287  AC27 HEK-293T C143(0.95)  LDD0885  [2]
 LDCM0288  AC28 HEK-293T C143(0.83)  LDD0886  [2]
 LDCM0289  AC29 HEK-293T C143(0.95)  LDD0887  [2]
 LDCM0290  AC3 HCT 116 C143(1.00); C144(1.00)  LDD0607  [2]
 LDCM0291  AC30 HEK-293T C143(1.11)  LDD0889  [2]
 LDCM0292  AC31 HEK-293T C143(0.95)  LDD0890  [2]
 LDCM0293  AC32 HEK-293T C143(1.01)  LDD0891  [2]
 LDCM0294  AC33 HEK-293T C143(1.16)  LDD0892  [2]
 LDCM0295  AC34 HEK-293T C143(1.14)  LDD0893  [2]
 LDCM0296  AC35 HEK-293T C143(1.07)  LDD0894  [2]
 LDCM0297  AC36 HEK-293T C143(1.02)  LDD0895  [2]
 LDCM0298  AC37 HEK-293T C143(0.87)  LDD0896  [2]
 LDCM0299  AC38 HEK-293T C143(1.08)  LDD0897  [2]
 LDCM0300  AC39 HEK-293T C143(0.87)  LDD0898  [2]
 LDCM0301  AC4 HCT 116 C143(1.04); C144(1.04)  LDD0618  [2]
 LDCM0302  AC40 HEK-293T C143(0.98)  LDD0900  [2]
 LDCM0303  AC41 HEK-293T C143(1.05)  LDD0901  [2]
 LDCM0304  AC42 HEK-293T C143(0.86)  LDD0902  [2]
 LDCM0305  AC43 HEK-293T C143(1.05)  LDD0903  [2]
 LDCM0306  AC44 HEK-293T C143(0.93)  LDD0904  [2]
 LDCM0307  AC45 HEK-293T C143(0.88)  LDD0905  [2]
 LDCM0308  AC46 HCT 116 C143(1.07); C144(1.07)  LDD0625  [2]
 LDCM0309  AC47 HCT 116 C143(0.80); C144(0.80)  LDD0626  [2]
 LDCM0310  AC48 HCT 116 C143(0.81); C144(0.81)  LDD0627  [2]
 LDCM0311  AC49 HCT 116 C143(1.11); C144(1.11)  LDD0628  [2]
 LDCM0312  AC5 HCT 116 C143(1.08); C144(1.08)  LDD0629  [2]
 LDCM0313  AC50 HCT 116 C143(1.03); C144(1.03)  LDD0630  [2]
 LDCM0314  AC51 HCT 116 C143(0.89); C144(0.89)  LDD0631  [2]
 LDCM0315  AC52 HCT 116 C143(0.98); C144(0.98)  LDD0632  [2]
 LDCM0316  AC53 HCT 116 C143(1.07); C144(1.07)  LDD0633  [2]
 LDCM0317  AC54 HCT 116 C143(1.08); C144(1.08)  LDD0634  [2]
 LDCM0318  AC55 HCT 116 C143(1.12); C144(1.12)  LDD0635  [2]
 LDCM0319  AC56 HCT 116 C143(1.55); C144(1.55)  LDD0636  [2]
 LDCM0320  AC57 PaTu 8988t C144(1.08); C143(1.08)  LDD1199  [2]
 LDCM0321  AC58 PaTu 8988t C144(1.13); C143(1.13)  LDD1200  [2]
 LDCM0322  AC59 PaTu 8988t C144(1.01); C143(1.01)  LDD1201  [2]
 LDCM0323  AC6 PaTu 8988t C144(1.25); C143(1.25)  LDD1202  [2]
 LDCM0324  AC60 PaTu 8988t C144(1.17); C143(1.17)  LDD1203  [2]
 LDCM0325  AC61 PaTu 8988t C144(1.05); C143(1.05)  LDD1204  [2]
 LDCM0326  AC62 PaTu 8988t C144(1.14); C143(1.14)  LDD1205  [2]
 LDCM0327  AC63 PaTu 8988t C144(1.22); C143(1.22)  LDD1206  [2]
 LDCM0328  AC64 PaTu 8988t C144(1.04); C143(1.04)  LDD1207  [2]
 LDCM0329  AC65 PaTu 8988t C144(0.96); C143(0.96)  LDD1208  [2]
 LDCM0330  AC66 PaTu 8988t C144(0.95); C143(0.95)  LDD1209  [2]
 LDCM0331  AC67 PaTu 8988t C144(0.99); C143(0.99)  LDD1210  [2]
 LDCM0332  AC68 HEK-293T C330(1.02)  LDD0930  [2]
 LDCM0333  AC69 HEK-293T C330(0.96)  LDD0931  [2]
 LDCM0334  AC7 PaTu 8988t C144(1.16); C143(1.16)  LDD1213  [2]
 LDCM0335  AC70 HEK-293T C330(1.38)  LDD0933  [2]
 LDCM0336  AC71 HEK-293T C330(1.22)  LDD0934  [2]
 LDCM0337  AC72 HEK-293T C330(1.09)  LDD0935  [2]
 LDCM0338  AC73 HEK-293T C330(1.21)  LDD0936  [2]
 LDCM0339  AC74 HEK-293T C330(1.27)  LDD0937  [2]
 LDCM0340  AC75 HEK-293T C330(1.28)  LDD0938  [2]
 LDCM0341  AC76 HEK-293T C330(1.07)  LDD0939  [2]
 LDCM0342  AC77 HEK-293T C330(1.12)  LDD0940  [2]
 LDCM0343  AC78 HEK-293T C330(0.92)  LDD0941  [2]
 LDCM0344  AC79 HEK-293T C330(0.97)  LDD0942  [2]
 LDCM0345  AC8 PaTu 8988t C144(1.29); C143(1.29)  LDD1224  [2]
 LDCM0346  AC80 HEK-293T C330(0.95)  LDD0944  [2]
 LDCM0347  AC81 HEK-293T C330(0.88)  LDD0945  [2]
 LDCM0348  AC82 HEK-293T C330(1.01)  LDD0946  [2]
 LDCM0349  AC83 PaTu 8988t C144(0.81); C143(0.81)  LDD1228  [2]
 LDCM0350  AC84 PaTu 8988t C144(0.76); C143(0.76)  LDD1229  [2]
 LDCM0351  AC85 PaTu 8988t C144(1.08); C143(1.08)  LDD1230  [2]
 LDCM0352  AC86 PaTu 8988t C144(0.76); C143(0.76)  LDD1231  [2]
 LDCM0353  AC87 PaTu 8988t C144(0.99); C143(0.99)  LDD1232  [2]
 LDCM0354  AC88 PaTu 8988t C144(1.09); C143(1.09)  LDD1233  [2]
 LDCM0355  AC89 PaTu 8988t C144(0.76); C143(0.76)  LDD1234  [2]
 LDCM0357  AC90 PaTu 8988t C144(0.71); C143(0.71)  LDD1236  [2]
 LDCM0358  AC91 PaTu 8988t C144(0.76); C143(0.76)  LDD1237  [2]
 LDCM0359  AC92 PaTu 8988t C144(0.79); C143(0.79)  LDD1238  [2]
 LDCM0360  AC93 PaTu 8988t C144(0.75); C143(0.75)  LDD1239  [2]
 LDCM0361  AC94 PaTu 8988t C144(0.82); C143(0.82)  LDD1240  [2]
 LDCM0362  AC95 PaTu 8988t C144(0.79); C143(0.79)  LDD1241  [2]
 LDCM0363  AC96 PaTu 8988t C144(0.97); C143(0.97)  LDD1242  [2]
 LDCM0364  AC97 PaTu 8988t C144(0.70); C143(0.70)  LDD1243  [2]
 LDCM0365  AC98 HEK-293T C143(0.87)  LDD0963  [2]
 LDCM0366  AC99 HEK-293T C143(0.89)  LDD0964  [2]
 LDCM0248  AKOS034007472 PaTu 8988t C144(1.29); C143(1.29)  LDD1127  [2]
 LDCM0356  AKOS034007680 PaTu 8988t C144(1.09); C143(1.09)  LDD1235  [2]
 LDCM0275  AKOS034007705 PaTu 8988t C144(1.15); C143(1.15)  LDD1154  [2]
 LDCM0020  ARS-1620 HCC44 C189(1.12); C190(1.12); C197(1.12)  LDD0078  [2]
 LDCM0108  Chloroacetamide HeLa N.A.  LDD0222  [1]
 LDCM0367  CL1 HEK-293T C144(1.08)  LDD1571  [7]
 LDCM0368  CL10 HEK-293T C52(0.98)  LDD1572  [7]
 LDCM0369  CL100 HCT 116 C143(1.08); C144(1.08)  LDD0686  [2]
 LDCM0370  CL101 PaTu 8988t C144(1.11); C143(1.11)  LDD1249  [2]
 LDCM0371  CL102 PaTu 8988t C144(1.08); C143(1.08)  LDD1250  [2]
 LDCM0372  CL103 PaTu 8988t C144(1.78); C143(1.78)  LDD1251  [2]
 LDCM0373  CL104 PaTu 8988t C144(1.18); C143(1.18)  LDD1252  [2]
 LDCM0374  CL105 HCT 116 C143(1.17); C144(1.17)  LDD0691  [2]
 LDCM0375  CL106 HCT 116 C143(1.31); C144(1.31)  LDD0692  [2]
 LDCM0376  CL107 HCT 116 C143(1.12); C144(1.12)  LDD0693  [2]
 LDCM0377  CL108 HCT 116 C143(1.25); C144(1.25)  LDD0694  [2]
 LDCM0378  CL109 HCT 116 C143(1.38); C144(1.38)  LDD0695  [2]
 LDCM0379  CL11 HEK-293T C52(0.97); C68(1.04)  LDD1583  [7]
 LDCM0380  CL110 HCT 116 C143(1.88); C144(1.88)  LDD0697  [2]
 LDCM0381  CL111 HCT 116 C143(1.23); C144(1.23)  LDD0698  [2]
 LDCM0382  CL112 HEK-293T C143(1.03)  LDD0980  [2]
 LDCM0383  CL113 HEK-293T C143(1.00)  LDD0981  [2]
 LDCM0384  CL114 HEK-293T C143(1.10)  LDD0982  [2]
 LDCM0385  CL115 HEK-293T C143(1.17)  LDD0983  [2]
 LDCM0386  CL116 HEK-293T C143(1.05)  LDD0984  [2]
 LDCM0387  CL117 HEK-293T C143(0.92)  LDD0985  [2]
 LDCM0388  CL118 HEK-293T C143(0.90)  LDD0986  [2]
 LDCM0389  CL119 HEK-293T C143(0.85)  LDD0987  [2]
 LDCM0390  CL12 HEK-293T C52(1.13)  LDD1594  [7]
 LDCM0391  CL120 HEK-293T C143(1.07)  LDD0989  [2]
 LDCM0392  CL121 HCT 116 C143(5.08); C144(5.08)  LDD0709  [2]
 LDCM0393  CL122 HCT 116 C143(0.96); C144(0.96)  LDD0710  [2]
 LDCM0394  CL123 HCT 116 C143(1.19); C144(1.19)  LDD0711  [2]
 LDCM0395  CL124 HCT 116 C143(1.01); C144(1.01)  LDD0712  [2]
 LDCM0396  CL125 PaTu 8988t C144(1.27); C143(1.27)  LDD1275  [2]
 LDCM0397  CL126 PaTu 8988t C144(1.17); C143(1.17)  LDD1276  [2]
 LDCM0398  CL127 PaTu 8988t C144(1.13); C143(1.13)  LDD1277  [2]
 LDCM0399  CL128 PaTu 8988t C144(1.02); C143(1.02)  LDD1278  [2]
 LDCM0400  CL13 HEK-293T C144(0.82)  LDD1604  [7]
 LDCM0401  CL14 HEK-293T C52(0.91); C144(0.87)  LDD1605  [7]
 LDCM0402  CL15 HEK-293T C52(1.23)  LDD1606  [7]
 LDCM0403  CL16 HEK-293T C330(1.03)  LDD1001  [2]
 LDCM0404  CL17 HEK-293T C330(0.80)  LDD1002  [2]
 LDCM0405  CL18 HEK-293T C330(0.82)  LDD1003  [2]
 LDCM0406  CL19 HEK-293T C330(0.83)  LDD1004  [2]
 LDCM0407  CL2 HEK-293T C52(0.98); C144(1.14)  LDD1611  [7]
 LDCM0408  CL20 HEK-293T C330(0.87)  LDD1006  [2]
 LDCM0409  CL21 HEK-293T C330(0.79)  LDD1007  [2]
 LDCM0410  CL22 HEK-293T C330(0.86)  LDD1008  [2]
 LDCM0411  CL23 HEK-293T C330(1.16)  LDD1009  [2]
 LDCM0412  CL24 HEK-293T C330(0.71)  LDD1010  [2]
 LDCM0413  CL25 HEK-293T C330(0.73)  LDD1011  [2]
 LDCM0414  CL26 HEK-293T C330(0.79)  LDD1012  [2]
 LDCM0415  CL27 HEK-293T C330(0.89)  LDD1013  [2]
 LDCM0416  CL28 HEK-293T C330(0.95)  LDD1014  [2]
 LDCM0417  CL29 HEK-293T C330(0.74)  LDD1015  [2]
 LDCM0418  CL3 HEK-293T C52(1.20)  LDD1622  [7]
 LDCM0419  CL30 HEK-293T C330(0.86)  LDD1017  [2]
 LDCM0420  CL31 HEK-293T C143(1.22); C330(2.06)  LDD1018  [2]
 LDCM0421  CL32 HEK-293T C143(1.11); C330(2.27)  LDD1019  [2]
 LDCM0422  CL33 HEK-293T C143(0.84); C330(1.69)  LDD1020  [2]
 LDCM0423  CL34 HEK-293T C143(1.31); C330(1.38)  LDD1021  [2]
 LDCM0424  CL35 HEK-293T C143(1.24); C330(1.91)  LDD1022  [2]
 LDCM0425  CL36 HEK-293T C143(1.20); C330(0.77)  LDD1023  [2]
 LDCM0426  CL37 HEK-293T C143(1.26); C330(1.39)  LDD1024  [2]
 LDCM0428  CL39 HEK-293T C143(0.80); C330(2.05)  LDD1026  [2]
 LDCM0430  CL40 HEK-293T C143(1.03); C330(1.11)  LDD1028  [2]
 LDCM0431  CL41 HEK-293T C143(1.00); C330(1.68)  LDD1029  [2]
 LDCM0432  CL42 HEK-293T C143(1.06); C330(1.33)  LDD1030  [2]
 LDCM0433  CL43 HEK-293T C143(1.02); C330(1.65)  LDD1031  [2]
 LDCM0434  CL44 HEK-293T C143(1.19); C330(2.18)  LDD1032  [2]
 LDCM0435  CL45 HEK-293T C143(1.06); C330(1.44)  LDD1033  [2]
 LDCM0436  CL46 PaTu 8988t C144(1.13); C143(1.13)  LDD1315  [2]
 LDCM0437  CL47 PaTu 8988t C144(1.24); C143(1.24)  LDD1316  [2]
 LDCM0438  CL48 PaTu 8988t C144(1.47); C143(1.47)  LDD1317  [2]
 LDCM0439  CL49 PaTu 8988t C144(1.23); C143(1.23)  LDD1318  [2]
 LDCM0440  CL5 HEK-293T C52(1.18)  LDD1644  [7]
 LDCM0441  CL50 PaTu 8988t C144(1.71); C143(1.71)  LDD1320  [2]
 LDCM0442  CL51 PaTu 8988t C144(1.84); C143(1.84)  LDD1321  [2]
 LDCM0443  CL52 PaTu 8988t C144(1.17); C143(1.17)  LDD1322  [2]
 LDCM0444  CL53 PaTu 8988t C144(1.31); C143(1.31)  LDD1323  [2]
 LDCM0445  CL54 PaTu 8988t C144(0.95); C143(0.95)  LDD1324  [2]
 LDCM0446  CL55 PaTu 8988t C144(1.22); C143(1.22)  LDD1325  [2]
 LDCM0447  CL56 PaTu 8988t C144(1.31); C143(1.31)  LDD1326  [2]
 LDCM0448  CL57 PaTu 8988t C144(1.25); C143(1.25)  LDD1327  [2]
 LDCM0449  CL58 PaTu 8988t C144(1.12); C143(1.12)  LDD1328  [2]
 LDCM0450  CL59 PaTu 8988t C144(1.29); C143(1.29)  LDD1329  [2]
 LDCM0451  CL6 HEK-293T C52(0.95)  LDD1654  [7]
 LDCM0452  CL60 PaTu 8988t C144(1.17); C143(1.17)  LDD1331  [2]
 LDCM0453  CL61 HCT 116 C143(0.92); C144(0.92)  LDD0770  [2]
 LDCM0454  CL62 HCT 116 C143(0.94); C144(0.94)  LDD0771  [2]
 LDCM0455  CL63 HCT 116 C143(1.20); C144(1.20)  LDD0772  [2]
 LDCM0456  CL64 HCT 116 C143(1.25); C144(1.25)  LDD0773  [2]
 LDCM0457  CL65 HCT 116 C143(1.02); C144(1.02)  LDD0774  [2]
 LDCM0458  CL66 HCT 116 C143(1.20); C144(1.20)  LDD0775  [2]
 LDCM0459  CL67 HCT 116 C143(1.01); C144(1.01)  LDD0776  [2]
 LDCM0460  CL68 HCT 116 C143(1.13); C144(1.13)  LDD0777  [2]
 LDCM0461  CL69 HCT 116 C143(0.93); C144(0.93)  LDD0778  [2]
 LDCM0462  CL7 HEK-293T C52(1.03); C68(1.12)  LDD1665  [7]
 LDCM0463  CL70 HCT 116 C143(1.13); C144(1.13)  LDD0780  [2]
 LDCM0464  CL71 HCT 116 C143(1.19); C144(1.19)  LDD0781  [2]
 LDCM0465  CL72 HCT 116 C143(0.91); C144(0.91)  LDD0782  [2]
 LDCM0466  CL73 HCT 116 C143(1.22); C144(1.22)  LDD0783  [2]
 LDCM0467  CL74 HCT 116 C143(0.91); C144(0.91)  LDD0784  [2]
 LDCM0469  CL76 PaTu 8988t C144(1.50); C143(1.50)  LDD1348  [2]
 LDCM0470  CL77 PaTu 8988t C144(1.20); C143(1.20)  LDD1349  [2]
 LDCM0471  CL78 PaTu 8988t C144(1.36); C143(1.36)  LDD1350  [2]
 LDCM0472  CL79 PaTu 8988t C144(1.87); C143(1.87)  LDD1351  [2]
 LDCM0474  CL80 PaTu 8988t C144(1.73); C143(1.73)  LDD1353  [2]
 LDCM0475  CL81 PaTu 8988t C144(1.63); C143(1.63)  LDD1354  [2]
 LDCM0476  CL82 PaTu 8988t C144(1.54); C143(1.54)  LDD1355  [2]
 LDCM0477  CL83 PaTu 8988t C144(1.72); C143(1.72)  LDD1356  [2]
 LDCM0478  CL84 PaTu 8988t C144(1.24); C143(1.24)  LDD1357  [2]
 LDCM0479  CL85 PaTu 8988t C144(1.26); C143(1.26)  LDD1358  [2]
 LDCM0480  CL86 PaTu 8988t C144(1.40); C143(1.40)  LDD1359  [2]
 LDCM0481  CL87 PaTu 8988t C144(0.87); C143(0.87)  LDD1360  [2]
 LDCM0482  CL88 PaTu 8988t C144(1.02); C143(1.02)  LDD1361  [2]
 LDCM0483  CL89 PaTu 8988t C144(1.14); C143(1.14)  LDD1362  [2]
 LDCM0484  CL9 HEK-293T C52(1.45)  LDD1687  [7]
 LDCM0485  CL90 PaTu 8988t C144(2.22); C143(2.22)  LDD1364  [2]
 LDCM0486  CL91 HCT 116 C143(1.03); C144(1.03)  LDD0803  [2]
 LDCM0487  CL92 HCT 116 C143(1.14); C144(1.14)  LDD0804  [2]
 LDCM0488  CL93 HCT 116 C143(0.77); C144(0.77)  LDD0805  [2]
 LDCM0489  CL94 HCT 116 C143(1.23); C144(1.23)  LDD0806  [2]
 LDCM0490  CL95 HCT 116 C143(1.12); C144(1.12)  LDD0807  [2]
 LDCM0491  CL96 HCT 116 C143(1.10); C144(1.10)  LDD0808  [2]
 LDCM0492  CL97 HCT 116 C143(1.25); C144(1.25)  LDD0809  [2]
 LDCM0493  CL98 HCT 116 C143(1.00); C144(1.00)  LDD0810  [2]
 LDCM0494  CL99 HCT 116 C143(0.94); C144(0.94)  LDD0811  [2]
 LDCM0495  E2913 HEK-293T C52(1.05)  LDD1698  [7]
 LDCM0468  Fragment33 HCT 116 C143(1.24); C144(1.24)  LDD0785  [2]
 LDCM0427  Fragment51 HEK-293T C143(1.12); C330(1.48)  LDD1025  [2]
 LDCM0022  KB02 HT-1376 C330(1.44)  LDD2370  [8]
 LDCM0023  KB03 Jurkat C68(13.68)  LDD0209  [9]
 LDCM0024  KB05 OE33 C330(2.66)  LDD3375  [8]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Other
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Melanoma-associated antigen 11 (MAGEA11) . P43364

References

1 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
2 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
3 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
4 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
5 Benchmarking Cleavable Biotin Tags for Peptide-Centric Chemoproteomics. J Proteome Res. 2022 May 6;21(5):1349-1358. doi: 10.1021/acs.jproteome.2c00174. Epub 2022 Apr 25.
Mass spectrometry data entry: PXD031019
6 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
7 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
8 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
9 Covalent Inhibition by a Natural Product-Inspired Latent Electrophile. J Am Chem Soc. 2023 May 24;145(20):11097-11109. doi: 10.1021/jacs.3c00598. Epub 2023 May 15.