Details of the Target

General Information of Target

Target ID LDTP07830
Target Name E3 ubiquitin-protein ligase UBR3 (UBR3)
Gene Name UBR3
Gene ID 130507
Synonyms
KIAA2024; ZNF650; E3 ubiquitin-protein ligase UBR3; EC 2.3.2.27; N-recognin-3; RING-type E3 ubiquitin transferase UBR3; Ubiquitin-protein ligase E3-alpha-3; Ubiquitin-protein ligase E3-alpha-III; Zinc finger protein 650
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MAAAAAAAVGGQQPSQPELPAPGLALDKAATAAHLKAALSRPDNRAGAEELQALLERVLS
AERPLAAAAGGEDAAAAGGGGGPGAAEEEALEWCKCLLAGGGGYDEFCAAVRAYDPAALC
GLVWTANFVAYRCRTCGISPCMSLCAECFHQGDHTGHDFNMFRSQAGGACDCGDSNVMRE
SGFCKRHQIKSSSNIPCVPKDLLMMSEFVLPRFIFCLIQYLREGYNEPAADGPSEKDLNK
VLQLLEPQISFLEDLTKMGGAMRSVLTQVLTNQQNYKDLTSGLGENACVKKSHEKYLIAL
KSSGLTYPEDKLVYGVQEPSAGTSSLAVQGFIGATGTLGQVDSSDEDDQDGSQGLGKRKR
VKLSSGTKDQSIMDVLKHKSFLEELLFWTIKYEFPQKMVTFLLNMLPDQEYKVAFTKTFV
QHYAFIMKTLKKSHESDTMSNRIVHISVQLFSNEELARQVTEECQLLDIMVTVLLYMMES
CLIKSELQDEENSLHVVVNCGEALLKNNTYWPLVSDFINILSHQSVAKRFLEDHGLLVTW
MNFVSFFQGMNLNKRELNEHVEFESQTYYAAFAAELEACAQPMWGLLSHCKVRETQEYTR
NVVRYCLEALQDWFDAINFVDEPAPNQVTFHLPLHRYYAMFLSKAVKCQELDLDSVLPDQ
EMLMKLMIHPLQIQASLAEIHSNMWVRNGLQIKGQAMTYVQSHFCNSMIDPDIYLLQVCA
SRLDPDYFISSVFERFKVVDLLTMASQHQNTVLDAEHERSMLEGALTFLVILLSLRLHLG
MSDDEILRAEMVAQLCMNDRTHSSLLDLIPENPNPKSGIIPGSYSFESVLSAVADFKAPV
FEPGGSMQQGMYTPKAEVWDQEFDPVMVILRTVYRRDVQSAMDRYTAFLKQSGKFPGNPW
PPYKKRTSLHPSYKGLMRLLHCKTLHIVLFTLLYKILMDHQNLSEHVLCMVLYLIELGLE
NSAEEESDEEASVGGPERCHDSWFPGSNLVSNMRHFINYVRVRVPETAPEVKRDSPASTS
SDNLGSLQNSGTAQVFSLVAERRKKFQEIINRSSSEANQVVRPKTSSKWSAPGSAPQLTT
AILEIKESILSLLIKLHHKLSGKQNSYYPPWLDDIEILIQPEIPKYSHGDGITAVERILL
KAASQSRMNKRIIEEICRKVTPPVPPKKVTAAEKKTLDKEERRQKARERQQKLLAEFASR
QKSFMETAMDVDSPENDIPMEITTAEPQVSEAVYDCVICGQSGPSSEDRPTGLVVLLQAS
SVLGQCRDNVEPKKLPISEEEQIYPWDTCAAVHDVRLSLLQRYFKDSSCLLAVSIGWEGG
VYVQTCGHTLHIDCHKSYMESLRNDQVLQGFSVDKGEFTCPLCRQFANSVLPCYPGSNVE
NNPWQRPSNKSIQDLIKEVEELQGRPGAFPSETNLSKEMESVMKDIKNTTQKKYRDYSKT
PGSPDNDFLFMYSVARTNLELELIHRGGNLCSGGASTAGKRSCLNQLFHVLALHMRLYSI
DSEYNPWRKLTQLEEMNPQLGYEEQQPEVPILYHDVTSLLLIQILMMPQPLRKDHFTCIV
KVLFTLLYTQALAALSVKCSEEDRSAWKHAGALKKSTCDAEKSYEVLLSFVISELFKGKL
YHEEGTQECAMVNPIAWSPESMEKCLQDFCLPFLRITSLLQHHLFGEDLPSCQEEEEFSV
LASCLGLLPTFYQTEHPFISASCLDWPVPAFDIITQWCFEIKSFTERHAEQGKALLIQES
KWKLPHLLQLPENYNTIFQYYHRKTCSVCTKVPKDPAVCLVCGTFVCLKGLCCKQQSYCE
CVLHSQNCGAGTGIFLLINASVIIIIRGHRFCLWGSVYLDAHGEEDRDLRRGKPLYICKE
RYKVLEQQWISHTFDHINKRWGPHYNGL
Target Bioclass
Enzyme
Family
UBR1 family
Subcellular location
Membrane
Function
E3 ubiquitin-protein ligase which is a component of the N-end rule pathway. Does not bind to proteins bearing specific N-terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation. May play a role in Shh signaling by mediating the ubiquitination of Kif7. May be important for MYH9 function in certain tissues, possibly by regulating the ubiquitination of MYH9 and consequently affecting its interaction with MYO7A.
Uniprot ID
Q6ZT12
Ensemble ID
ENST00000272793.11
HGNC ID
HGNC:30467

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
ECC2 SNV: p.V739G .
HCT15 SNV: p.L552I .
HEC1 SNV: p.R555Ter DBIA    Probe Info 
IGR1 SNV: p.S250F DBIA    Probe Info 
IGROV1 SNV: p.Q1716H .
IPC298 Deletion: p.K1561_L1563del .
K562 SNV: p.H1098Q .
KP4 SNV: p.P1285S .
KYM1 SNV: p.S320Y .
MDAMB453 SNV: p.E1720K .
MFE319 SNV: p.R1249Q .
RKO SNV: p.G356D .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 6 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C288(4.81)  LDD0209  [2]
IA-alkyne
 Probe Info  		N.A.  LDD0036  [3]
Lodoacetamide azide
 Probe Info  		C120(0.00); C1471(0.00); C1766(0.00); C1769(0.00)  LDD0037  [3]
IPM
 Probe Info  		N.A.  LDD0147  [4]
TFBX
 Probe Info  		C1579(0.00); C1858(0.00)  LDD0148  [4]
NAIA_5
 Probe Info  		N.A.  LDD2223  [5]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 PaTu 8988t C1650(0.38); C1645(0.38); C1858(1.71)  LDD1093  [6]
 LDCM0215  AC10 PaTu 8988t C1645(0.98); C1858(1.47)  LDD1094  [6]
 LDCM0216  AC100 PaTu 8988t C1858(1.24)  LDD1095  [6]
 LDCM0217  AC101 PaTu 8988t C1858(1.08)  LDD1096  [6]
 LDCM0218  AC102 PaTu 8988t C1858(1.22)  LDD1097  [6]
 LDCM0219  AC103 PaTu 8988t C1858(1.16)  LDD1098  [6]
 LDCM0220  AC104 PaTu 8988t C1858(1.05)  LDD1099  [6]
 LDCM0221  AC105 PaTu 8988t C1858(1.24)  LDD1100  [6]
 LDCM0222  AC106 PaTu 8988t C1858(1.56)  LDD1101  [6]
 LDCM0223  AC107 PaTu 8988t C1858(0.98)  LDD1102  [6]
 LDCM0224  AC108 PaTu 8988t C1858(1.04)  LDD1103  [6]
 LDCM0225  AC109 PaTu 8988t C1858(1.41)  LDD1104  [6]
 LDCM0226  AC11 PaTu 8988t C1645(0.76); C1858(1.41)  LDD1105  [6]
 LDCM0227  AC110 PaTu 8988t C1858(1.21)  LDD1106  [6]
 LDCM0228  AC111 PaTu 8988t C1858(1.49)  LDD1107  [6]
 LDCM0229  AC112 PaTu 8988t C1858(1.39)  LDD1108  [6]
 LDCM0230  AC113 PaTu 8988t C1858(0.49)  LDD1109  [6]
 LDCM0231  AC114 PaTu 8988t C1858(0.57)  LDD1110  [6]
 LDCM0232  AC115 PaTu 8988t C1858(0.47)  LDD1111  [6]
 LDCM0233  AC116 PaTu 8988t C1858(0.59)  LDD1112  [6]
 LDCM0234  AC117 PaTu 8988t C1858(0.77)  LDD1113  [6]
 LDCM0235  AC118 PaTu 8988t C1858(0.90)  LDD1114  [6]
 LDCM0236  AC119 PaTu 8988t C1858(0.84)  LDD1115  [6]
 LDCM0237  AC12 PaTu 8988t C1645(0.73); C1858(1.68)  LDD1116  [6]
 LDCM0238  AC120 PaTu 8988t C1858(0.90)  LDD1117  [6]
 LDCM0239  AC121 PaTu 8988t C1858(0.93)  LDD1118  [6]
 LDCM0240  AC122 PaTu 8988t C1858(0.80)  LDD1119  [6]
 LDCM0241  AC123 PaTu 8988t C1858(0.72)  LDD1120  [6]
 LDCM0242  AC124 PaTu 8988t C1858(1.03)  LDD1121  [6]
 LDCM0243  AC125 PaTu 8988t C1858(0.63)  LDD1122  [6]
 LDCM0244  AC126 PaTu 8988t C1858(0.68)  LDD1123  [6]
 LDCM0245  AC127 PaTu 8988t C1858(0.92)  LDD1124  [6]
 LDCM0246  AC128 PaTu 8988t C1858(1.28)  LDD1125  [6]
 LDCM0247  AC129 PaTu 8988t C1858(1.56)  LDD1126  [6]
 LDCM0249  AC130 PaTu 8988t C1858(1.37)  LDD1128  [6]
 LDCM0250  AC131 PaTu 8988t C1858(1.51)  LDD1129  [6]
 LDCM0251  AC132 PaTu 8988t C1858(1.23)  LDD1130  [6]
 LDCM0252  AC133 PaTu 8988t C1858(2.58)  LDD1131  [6]
 LDCM0253  AC134 PaTu 8988t C1858(1.84)  LDD1132  [6]
 LDCM0254  AC135 PaTu 8988t C1858(2.38)  LDD1133  [6]
 LDCM0255  AC136 PaTu 8988t C1858(1.56)  LDD1134  [6]
 LDCM0256  AC137 PaTu 8988t C1858(2.50)  LDD1135  [6]
 LDCM0257  AC138 PaTu 8988t C1858(1.88)  LDD1136  [6]
 LDCM0258  AC139 PaTu 8988t C1858(1.51)  LDD1137  [6]
 LDCM0259  AC14 PaTu 8988t C1645(0.69); C1858(1.18)  LDD1138  [6]
 LDCM0260  AC140 PaTu 8988t C1858(1.19)  LDD1139  [6]
 LDCM0261  AC141 PaTu 8988t C1858(1.26)  LDD1140  [6]
 LDCM0262  AC142 PaTu 8988t C1858(1.52)  LDD1141  [6]
 LDCM0263  AC143 PaTu 8988t C1779(0.82); C1782(0.88); C1787(0.88); C1483(1.53)  LDD1142  [6]
 LDCM0264  AC144 PaTu 8988t C1779(1.08); C1782(1.05); C1787(1.05); C1483(1.27)  LDD1143  [6]
 LDCM0265  AC145 PaTu 8988t C1779(0.95); C1782(0.95); C1787(0.95); C1483(0.87)  LDD1144  [6]
 LDCM0266  AC146 PaTu 8988t C1779(1.00); C1782(1.01); C1787(1.01); C1483(0.85)  LDD1145  [6]
 LDCM0267  AC147 PaTu 8988t C1779(0.90); C1782(0.97); C1787(0.97); C1483(1.24)  LDD1146  [6]
 LDCM0268  AC148 PaTu 8988t C1779(0.83); C1782(0.95); C1787(0.95); C1483(0.79)  LDD1147  [6]
 LDCM0269  AC149 PaTu 8988t C1779(0.68); C1782(0.76); C1787(0.76); C1483(0.91)  LDD1148  [6]
 LDCM0270  AC15 PaTu 8988t C1645(0.79); C1858(1.35)  LDD1149  [6]
 LDCM0271  AC150 PaTu 8988t C1779(0.93); C1782(0.98); C1787(0.98); C1483(0.82)  LDD1150  [6]
 LDCM0272  AC151 PaTu 8988t C1779(0.81); C1782(0.90); C1787(0.90); C1483(1.13)  LDD1151  [6]
 LDCM0273  AC152 PaTu 8988t C1779(0.69); C1782(0.86); C1787(0.86); C1483(1.07)  LDD1152  [6]
 LDCM0274  AC153 PaTu 8988t C1779(0.66); C1782(0.77); C1787(0.77); C1483(0.59)  LDD1153  [6]
 LDCM0621  AC154 PaTu 8988t C1779(0.97); C1782(0.93); C1787(0.93); C1483(0.96)  LDD2166  [6]
 LDCM0622  AC155 PaTu 8988t C1779(0.97); C1782(0.99); C1787(0.99); C1483(0.86)  LDD2167  [6]
 LDCM0623  AC156 PaTu 8988t C1779(0.73); C1782(0.79); C1787(0.79); C1483(1.09)  LDD2168  [6]
 LDCM0624  AC157 PaTu 8988t C1779(1.02); C1782(1.08); C1787(1.08); C1483(0.75)  LDD2169  [6]
 LDCM0276  AC17 PaTu 8988t C1858(1.03)  LDD1155  [6]
 LDCM0277  AC18 PaTu 8988t C1858(1.43)  LDD1156  [6]
 LDCM0278  AC19 PaTu 8988t C1858(1.26)  LDD1157  [6]
 LDCM0279  AC2 PaTu 8988t C1650(0.78); C1645(0.78); C1858(1.22)  LDD1158  [6]
 LDCM0280  AC20 PaTu 8988t C1858(1.20)  LDD1159  [6]
 LDCM0281  AC21 PaTu 8988t C1858(1.17)  LDD1160  [6]
 LDCM0282  AC22 PaTu 8988t C1858(1.25)  LDD1161  [6]
 LDCM0283  AC23 PaTu 8988t C1858(1.80)  LDD1162  [6]
 LDCM0284  AC24 PaTu 8988t C1858(1.43)  LDD1163  [6]
 LDCM0285  AC25 HEK-293T C197(0.99); C288(0.92); C1858(1.07); C1645(0.63)  LDD1524  [7]
 LDCM0286  AC26 HEK-293T C197(0.95); C1858(0.96); C1598(0.93); C1645(0.78)  LDD1525  [7]
 LDCM0287  AC27 HEK-293T C197(1.03); C1858(0.99)  LDD1526  [7]
 LDCM0288  AC28 HEK-293T C197(0.97); C288(1.05); C1858(1.06); C1598(1.00)  LDD1527  [7]
 LDCM0289  AC29 HEK-293T C197(0.96); C288(1.08); C1858(1.05); C1598(1.00)  LDD1528  [7]
 LDCM0290  AC3 PaTu 8988t C1650(0.81); C1645(0.81); C1858(1.31)  LDD1169  [6]
 LDCM0291  AC30 HEK-293T C197(0.94); C288(0.91); C1858(1.09); C1598(0.98)  LDD1530  [7]
 LDCM0292  AC31 HEK-293T C197(0.99); C1858(1.02); C1598(0.92); C1645(1.24)  LDD1531  [7]
 LDCM0293  AC32 HEK-293T C288(0.97); C1858(0.94); C1629(0.92)  LDD1532  [7]
 LDCM0294  AC33 HEK-293T C197(1.02); C288(1.17); C1858(1.01); C1645(0.87)  LDD1533  [7]
 LDCM0295  AC34 HEK-293T C197(1.04); C1858(1.23); C1598(1.00); C1645(0.82)  LDD1534  [7]
 LDCM0296  AC35 PaTu 8988t C1650(0.92); C1645(0.92)  LDD1175  [6]
 LDCM0297  AC36 PaTu 8988t C1650(0.68); C1645(0.68)  LDD1176  [6]
 LDCM0298  AC37 PaTu 8988t C1650(0.74); C1645(0.74)  LDD1177  [6]
 LDCM0299  AC38 PaTu 8988t C1650(0.65); C1645(0.65)  LDD1178  [6]
 LDCM0300  AC39 PaTu 8988t C1650(0.63); C1645(0.63)  LDD1179  [6]
 LDCM0301  AC4 PaTu 8988t C1650(0.95); C1645(0.95); C1858(1.25)  LDD1180  [6]
 LDCM0302  AC40 PaTu 8988t C1650(0.46); C1645(0.46)  LDD1181  [6]
 LDCM0303  AC41 PaTu 8988t C1650(0.64); C1645(0.64)  LDD1182  [6]
 LDCM0304  AC42 PaTu 8988t C1650(0.56); C1645(0.56)  LDD1183  [6]
 LDCM0305  AC43 PaTu 8988t C1650(0.74); C1645(0.74)  LDD1184  [6]
 LDCM0306  AC44 PaTu 8988t C1650(0.42); C1645(0.42)  LDD1185  [6]
 LDCM0307  AC45 PaTu 8988t C1650(0.57); C1645(0.57)  LDD1186  [6]
 LDCM0308  AC46 PaTu 8988t C1483(0.89); C1650(0.82); C1645(0.82)  LDD1187  [6]
 LDCM0309  AC47 PaTu 8988t C1483(1.28); C1650(0.83); C1645(0.83)  LDD1188  [6]
 LDCM0310  AC48 PaTu 8988t C1483(0.75); C1650(0.72); C1645(0.72)  LDD1189  [6]
 LDCM0311  AC49 PaTu 8988t C1483(0.72); C1650(0.50); C1645(0.50)  LDD1190  [6]
 LDCM0312  AC5 PaTu 8988t C1650(0.49); C1645(0.49); C1858(1.64)  LDD1191  [6]
 LDCM0313  AC50 PaTu 8988t C1483(0.60); C1650(0.39); C1645(0.39)  LDD1192  [6]
 LDCM0314  AC51 PaTu 8988t C1483(0.26); C1650(0.21); C1645(0.21)  LDD1193  [6]
 LDCM0315  AC52 PaTu 8988t C1483(1.17); C1650(0.68); C1645(0.68)  LDD1194  [6]
 LDCM0316  AC53 PaTu 8988t C1483(0.57); C1650(0.38); C1645(0.38)  LDD1195  [6]
 LDCM0317  AC54 PaTu 8988t C1483(0.54); C1650(0.39); C1645(0.39)  LDD1196  [6]
 LDCM0318  AC55 PaTu 8988t C1483(1.36); C1650(0.90); C1645(0.90)  LDD1197  [6]
 LDCM0319  AC56 PaTu 8988t C1483(1.19); C1650(0.78); C1645(0.78)  LDD1198  [6]
 LDCM0320  AC57 PaTu 8988t C1650(1.09); C1645(1.09)  LDD1199  [6]
 LDCM0321  AC58 PaTu 8988t C1650(1.12); C1645(1.12)  LDD1200  [6]
 LDCM0322  AC59 PaTu 8988t C1650(1.47); C1645(1.47)  LDD1201  [6]
 LDCM0323  AC6 PaTu 8988t C1645(0.91); C1858(1.14)  LDD1202  [6]
 LDCM0324  AC60 PaTu 8988t C1650(1.42); C1645(1.42)  LDD1203  [6]
 LDCM0325  AC61 PaTu 8988t C1650(1.43); C1645(1.43)  LDD1204  [6]
 LDCM0326  AC62 PaTu 8988t C1650(1.24); C1645(1.24)  LDD1205  [6]
 LDCM0327  AC63 PaTu 8988t C1650(1.24); C1645(1.24)  LDD1206  [6]
 LDCM0328  AC64 PaTu 8988t C1650(1.34); C1645(1.34)  LDD1207  [6]
 LDCM0329  AC65 PaTu 8988t C1650(1.16); C1645(1.16)  LDD1208  [6]
 LDCM0330  AC66 PaTu 8988t C1650(1.16); C1645(1.16)  LDD1209  [6]
 LDCM0331  AC67 PaTu 8988t C1650(1.37); C1645(1.37)  LDD1210  [6]
 LDCM0332  AC68 PaTu 8988t C1650(1.14); C1645(1.14)  LDD1211  [6]
 LDCM0333  AC69 PaTu 8988t C1650(0.88); C1645(0.88)  LDD1212  [6]
 LDCM0334  AC7 PaTu 8988t C1645(0.89); C1858(1.23)  LDD1213  [6]
 LDCM0335  AC70 PaTu 8988t C1650(0.96); C1645(0.96)  LDD1214  [6]
 LDCM0336  AC71 PaTu 8988t C1650(1.15); C1645(1.15)  LDD1215  [6]
 LDCM0337  AC72 PaTu 8988t C1650(1.04); C1645(1.04)  LDD1216  [6]
 LDCM0338  AC73 PaTu 8988t C1650(1.15); C1645(1.15)  LDD1217  [6]
 LDCM0339  AC74 PaTu 8988t C1650(1.06); C1645(1.06)  LDD1218  [6]
 LDCM0340  AC75 PaTu 8988t C1650(0.86); C1645(0.86)  LDD1219  [6]
 LDCM0341  AC76 PaTu 8988t C1650(0.92); C1645(0.92)  LDD1220  [6]
 LDCM0342  AC77 PaTu 8988t C1650(0.89); C1645(0.89)  LDD1221  [6]
 LDCM0343  AC78 PaTu 8988t C1650(0.86); C1645(0.86)  LDD1222  [6]
 LDCM0344  AC79 PaTu 8988t C1650(1.00); C1645(1.00)  LDD1223  [6]
 LDCM0345  AC8 PaTu 8988t C1645(1.05); C1858(1.13)  LDD1224  [6]
 LDCM0346  AC80 PaTu 8988t C1650(0.98); C1645(0.98)  LDD1225  [6]
 LDCM0347  AC81 PaTu 8988t C1650(0.96); C1645(0.96)  LDD1226  [6]
 LDCM0348  AC82 PaTu 8988t C1650(0.90); C1645(0.90)  LDD1227  [6]
 LDCM0349  AC83 PaTu 8988t C1650(1.43); C1645(1.43)  LDD1228  [6]
 LDCM0350  AC84 PaTu 8988t C1650(1.61); C1645(1.61)  LDD1229  [6]
 LDCM0351  AC85 PaTu 8988t C1650(1.81); C1645(1.81)  LDD1230  [6]
 LDCM0352  AC86 PaTu 8988t C1650(1.34); C1645(1.34)  LDD1231  [6]
 LDCM0353  AC87 PaTu 8988t C1650(1.65); C1645(1.65)  LDD1232  [6]
 LDCM0354  AC88 PaTu 8988t C1650(1.61); C1645(1.61)  LDD1233  [6]
 LDCM0355  AC89 PaTu 8988t C1650(1.45); C1645(1.45)  LDD1234  [6]
 LDCM0357  AC90 PaTu 8988t C1650(2.21); C1645(2.21)  LDD1236  [6]
 LDCM0358  AC91 PaTu 8988t C1650(2.02); C1645(2.02)  LDD1237  [6]
 LDCM0359  AC92 PaTu 8988t C1650(1.53); C1645(1.53)  LDD1238  [6]
 LDCM0360  AC93 PaTu 8988t C1650(1.68); C1645(1.68)  LDD1239  [6]
 LDCM0361  AC94 PaTu 8988t C1650(1.45); C1645(1.45)  LDD1240  [6]
 LDCM0362  AC95 PaTu 8988t C1650(1.46); C1645(1.46)  LDD1241  [6]
 LDCM0363  AC96 PaTu 8988t C1650(2.21); C1645(2.21)  LDD1242  [6]
 LDCM0364  AC97 PaTu 8988t C1650(1.80); C1645(1.80)  LDD1243  [6]
 LDCM0365  AC98 PaTu 8988t C1858(1.22)  LDD1244  [6]
 LDCM0366  AC99 PaTu 8988t C1858(1.29)  LDD1245  [6]
 LDCM0248  AKOS034007472 PaTu 8988t C1645(0.77); C1858(1.15)  LDD1127  [6]
 LDCM0356  AKOS034007680 PaTu 8988t C1645(0.99); C1858(2.28)  LDD1235  [6]
 LDCM0275  AKOS034007705 PaTu 8988t C1645(0.93); C1858(1.88)  LDD1154  [6]
 LDCM0632  CL-Sc Hep-G2 C288(20.00)  LDD2227  [5]
 LDCM0367  CL1 PaTu 8988t C1766(0.87); C1769(1.61); C1483(1.19); C1858(1.35)  LDD1246  [6]
 LDCM0368  CL10 PaTu 8988t C1766(0.54); C1769(0.78); C1483(0.66); C1858(2.31)  LDD1247  [6]
 LDCM0369  CL100 PaTu 8988t C1650(0.89); C1645(0.89); C1858(1.31)  LDD1248  [6]
 LDCM0370  CL101 PaTu 8988t C1645(0.97); C1858(1.41)  LDD1249  [6]
 LDCM0371  CL102 PaTu 8988t C1645(0.89); C1858(1.81)  LDD1250  [6]
 LDCM0372  CL103 PaTu 8988t C1645(0.59); C1858(1.52)  LDD1251  [6]
 LDCM0373  CL104 PaTu 8988t C1645(0.77); C1858(1.34)  LDD1252  [6]
 LDCM0374  CL105 PaTu 8988t C1858(1.30)  LDD1253  [6]
 LDCM0375  CL106 PaTu 8988t C1858(1.11)  LDD1254  [6]
 LDCM0376  CL107 PaTu 8988t C1858(1.12)  LDD1255  [6]
 LDCM0377  CL108 PaTu 8988t C1858(1.15)  LDD1256  [6]
 LDCM0378  CL109 PaTu 8988t C1858(1.21)  LDD1257  [6]
 LDCM0379  CL11 PaTu 8988t C1766(0.97); C1769(0.85); C1483(0.84); C1858(1.69)  LDD1258  [6]
 LDCM0380  CL110 PaTu 8988t C1858(1.39)  LDD1259  [6]
 LDCM0381  CL111 PaTu 8988t C1858(1.66)  LDD1260  [6]
 LDCM0382  CL112 HEK-293T C197(0.95); C288(1.04); C648(0.93); C1769(1.04)  LDD1586  [7]
 LDCM0383  CL113 HEK-293T C197(1.02); C288(0.97)  LDD1587  [7]
 LDCM0384  CL114 HEK-293T C197(1.07); C216(1.03); C1858(1.01); C1645(0.56)  LDD1588  [7]
 LDCM0385  CL115 HEK-293T C197(0.89); C288(0.93); C1858(1.15); C1645(1.10)  LDD1589  [7]
 LDCM0386  CL116 HEK-293T C197(0.96); C288(0.77); C648(0.89); C1769(1.18)  LDD1590  [7]
 LDCM0387  CL117 PaTu 8988t C1650(0.69); C1645(0.69)  LDD1266  [6]
 LDCM0388  CL118 PaTu 8988t C1650(0.80); C1645(0.80)  LDD1267  [6]
 LDCM0389  CL119 PaTu 8988t C1650(0.63); C1645(0.63)  LDD1268  [6]
 LDCM0390  CL12 PaTu 8988t C1766(0.77); C1769(0.92); C1483(0.81); C1858(1.73)  LDD1269  [6]
 LDCM0391  CL120 PaTu 8988t C1650(0.91); C1645(0.91)  LDD1270  [6]
 LDCM0392  CL121 PaTu 8988t C1483(0.78); C1650(0.77); C1645(0.77)  LDD1271  [6]
 LDCM0393  CL122 PaTu 8988t C1483(1.35); C1650(0.84); C1645(0.84)  LDD1272  [6]
 LDCM0394  CL123 PaTu 8988t C1483(0.76); C1650(0.64); C1645(0.64)  LDD1273  [6]
 LDCM0395  CL124 PaTu 8988t C1483(0.52); C1650(0.52); C1645(0.52)  LDD1274  [6]
 LDCM0396  CL125 PaTu 8988t C1650(1.22); C1645(1.22)  LDD1275  [6]
 LDCM0397  CL126 PaTu 8988t C1650(1.18); C1645(1.18)  LDD1276  [6]
 LDCM0398  CL127 PaTu 8988t C1650(1.14); C1645(1.14)  LDD1277  [6]
 LDCM0399  CL128 PaTu 8988t C1650(1.26); C1645(1.26)  LDD1278  [6]
 LDCM0400  CL13 PaTu 8988t C1766(0.63); C1769(0.96); C1483(0.76); C1858(1.58)  LDD1279  [6]
 LDCM0401  CL14 PaTu 8988t C1766(0.63); C1769(1.03); C1483(1.18); C1858(1.69)  LDD1280  [6]
 LDCM0402  CL15 PaTu 8988t C1766(0.71); C1769(0.73); C1483(0.95); C1858(2.30)  LDD1281  [6]
 LDCM0403  CL16 PaTu 8988t C1779(0.86); C1782(0.86); C1787(0.86)  LDD1282  [6]
 LDCM0404  CL17 PaTu 8988t C1779(0.57); C1782(0.57); C1787(0.57)  LDD1283  [6]
 LDCM0405  CL18 PaTu 8988t C1779(0.49); C1782(0.49); C1787(0.49)  LDD1284  [6]
 LDCM0406  CL19 PaTu 8988t C1779(0.59); C1782(0.59); C1787(0.59)  LDD1285  [6]
 LDCM0407  CL2 PaTu 8988t C1766(0.77); C1769(0.97); C1483(0.87); C1858(1.04)  LDD1286  [6]
 LDCM0408  CL20 PaTu 8988t C1779(0.69); C1782(0.69); C1787(0.69)  LDD1287  [6]
 LDCM0409  CL21 PaTu 8988t C1779(0.65); C1782(0.65); C1787(0.65)  LDD1288  [6]
 LDCM0410  CL22 PaTu 8988t C1779(0.56); C1782(0.56); C1787(0.56)  LDD1289  [6]
 LDCM0411  CL23 PaTu 8988t C1779(0.70); C1782(0.70); C1787(0.70)  LDD1290  [6]
 LDCM0412  CL24 PaTu 8988t C1779(0.72); C1782(0.72); C1787(0.72)  LDD1291  [6]
 LDCM0413  CL25 PaTu 8988t C1779(0.78); C1782(0.78); C1787(0.78)  LDD1292  [6]
 LDCM0414  CL26 PaTu 8988t C1779(0.52); C1782(0.52); C1787(0.52)  LDD1293  [6]
 LDCM0415  CL27 PaTu 8988t C1779(0.75); C1782(0.75); C1787(0.75)  LDD1294  [6]
 LDCM0416  CL28 PaTu 8988t C1779(0.73); C1782(0.73); C1787(0.73)  LDD1295  [6]
 LDCM0417  CL29 PaTu 8988t C1779(0.76); C1782(0.76); C1787(0.76)  LDD1296  [6]
 LDCM0418  CL3 PaTu 8988t C1766(0.98); C1769(1.02); C1483(0.94); C1858(1.16)  LDD1297  [6]
 LDCM0419  CL30 PaTu 8988t C1779(0.91); C1782(0.91); C1787(0.91)  LDD1298  [6]
 LDCM0420  CL31 PaTu 8988t C1779(0.93); C1782(0.93); C1787(0.93); C1483(1.13)  LDD1299  [6]
 LDCM0421  CL32 PaTu 8988t C1779(0.73); C1782(0.73); C1787(0.73); C1483(0.89)  LDD1300  [6]
 LDCM0422  CL33 PaTu 8988t C1779(0.65); C1782(0.65); C1787(0.65); C1483(1.06)  LDD1301  [6]
 LDCM0423  CL34 PaTu 8988t C1779(0.75); C1782(0.75); C1787(0.75); C1483(0.97)  LDD1302  [6]
 LDCM0424  CL35 PaTu 8988t C1858(1.30); C1779(0.63); C1782(0.63); C1787(0.63)  LDD1303  [6]
 LDCM0425  CL36 PaTu 8988t C1779(0.90); C1782(0.90); C1787(0.90); C1483(1.08)  LDD1304  [6]
 LDCM0426  CL37 PaTu 8988t C1779(0.59); C1782(0.59); C1787(0.59); C1483(0.92)  LDD1305  [6]
 LDCM0428  CL39 PaTu 8988t C1779(0.88); C1782(0.88); C1787(0.88); C1483(1.30)  LDD1307  [6]
 LDCM0429  CL4 PaTu 8988t C1766(1.07); C1769(1.16); C1483(0.99); C1858(1.12)  LDD1308  [6]
 LDCM0430  CL40 PaTu 8988t C1779(0.85); C1782(0.85); C1787(0.85); C1483(1.12)  LDD1309  [6]
 LDCM0431  CL41 PaTu 8988t C1779(0.59); C1782(0.59); C1787(0.59); C1483(0.78)  LDD1310  [6]
 LDCM0432  CL42 PaTu 8988t C1779(0.54); C1782(0.54); C1787(0.54); C1483(1.06)  LDD1311  [6]
 LDCM0433  CL43 PaTu 8988t C1779(0.53); C1782(0.53); C1787(0.53); C1483(1.05)  LDD1312  [6]
 LDCM0434  CL44 PaTu 8988t C1779(0.59); C1782(0.59); C1787(0.59); C1483(0.92)  LDD1313  [6]
 LDCM0435  CL45 PaTu 8988t C1779(0.89); C1782(0.89); C1787(0.89); C1483(1.08)  LDD1314  [6]
 LDCM0436  CL46 PaTu 8988t C1766(0.83); C1769(0.83); C1858(1.18)  LDD1315  [6]
 LDCM0437  CL47 PaTu 8988t C1766(0.95); C1769(0.95); C1858(0.94)  LDD1316  [6]
 LDCM0438  CL48 PaTu 8988t C1766(0.93); C1769(0.93); C1858(0.93)  LDD1317  [6]
 LDCM0439  CL49 PaTu 8988t C1766(1.01); C1769(1.01); C1858(0.94)  LDD1318  [6]
 LDCM0440  CL5 PaTu 8988t C1766(0.61); C1769(0.88); C1483(0.78); C1858(1.23)  LDD1319  [6]
 LDCM0441  CL50 PaTu 8988t C1766(0.86); C1769(0.86); C1858(1.02)  LDD1320  [6]
 LDCM0442  CL51 PaTu 8988t C1766(0.89); C1769(0.89); C1858(1.06)  LDD1321  [6]
 LDCM0443  CL52 PaTu 8988t C1766(0.82); C1769(0.82); C1858(1.17)  LDD1322  [6]
 LDCM0444  CL53 PaTu 8988t C1766(1.13); C1769(1.13); C1858(1.15)  LDD1323  [6]
 LDCM0445  CL54 PaTu 8988t C1766(0.94); C1769(0.94); C1858(1.05)  LDD1324  [6]
 LDCM0446  CL55 PaTu 8988t C1766(0.87); C1769(0.87); C1858(0.89)  LDD1325  [6]
 LDCM0447  CL56 PaTu 8988t C1766(0.84); C1769(0.84); C1858(0.67)  LDD1326  [6]
 LDCM0448  CL57 PaTu 8988t C1766(1.06); C1769(1.06); C1858(1.41)  LDD1327  [6]
 LDCM0449  CL58 PaTu 8988t C1766(1.03); C1769(1.03); C1858(1.10)  LDD1328  [6]
 LDCM0450  CL59 PaTu 8988t C1766(0.86); C1769(0.86); C1858(1.18)  LDD1329  [6]
 LDCM0451  CL6 PaTu 8988t C1766(0.58); C1769(0.64); C1483(0.77); C1858(1.11)  LDD1330  [6]
 LDCM0452  CL60 PaTu 8988t C1766(0.92); C1769(0.92); C1858(1.07)  LDD1331  [6]
 LDCM0453  CL61 PaTu 8988t C1766(1.02); C1769(1.02); C1779(1.02); C1782(1.02)  LDD1332  [6]
 LDCM0454  CL62 PaTu 8988t C1766(1.21); C1769(1.21); C1779(0.88); C1782(0.88)  LDD1333  [6]
 LDCM0455  CL63 PaTu 8988t C1766(1.06); C1769(1.06); C1779(0.95); C1782(0.95)  LDD1334  [6]
 LDCM0456  CL64 PaTu 8988t C1766(0.90); C1769(0.90); C1779(0.71); C1782(0.71)  LDD1335  [6]
 LDCM0457  CL65 PaTu 8988t C1766(0.89); C1769(0.89); C1779(0.84); C1782(0.84)  LDD1336  [6]
 LDCM0458  CL66 PaTu 8988t C1766(0.95); C1769(0.95); C1779(0.92); C1782(0.92)  LDD1337  [6]
 LDCM0459  CL67 PaTu 8988t C1766(0.57); C1769(0.57); C1779(1.28); C1782(1.28)  LDD1338  [6]
 LDCM0460  CL68 PaTu 8988t C1766(0.63); C1769(0.63); C1779(0.90); C1782(0.90)  LDD1339  [6]
 LDCM0461  CL69 PaTu 8988t C1766(0.64); C1769(0.64); C1779(0.63); C1782(0.63)  LDD1340  [6]
 LDCM0462  CL7 PaTu 8988t C1766(0.60); C1769(0.79); C1483(0.57); C1858(1.39)  LDD1341  [6]
 LDCM0463  CL70 PaTu 8988t C1766(0.70); C1769(0.70); C1779(0.91); C1782(0.91)  LDD1342  [6]
 LDCM0464  CL71 PaTu 8988t C1766(1.03); C1769(1.03); C1779(0.79); C1782(0.79)  LDD1343  [6]
 LDCM0465  CL72 PaTu 8988t C1766(1.39); C1769(1.39); C1779(0.94); C1782(0.94)  LDD1344  [6]
 LDCM0466  CL73 PaTu 8988t C1766(0.67); C1769(0.67); C1779(0.87); C1782(0.87)  LDD1345  [6]
 LDCM0467  CL74 PaTu 8988t C1766(1.11); C1769(1.11); C1779(0.97); C1782(0.97)  LDD1346  [6]
 LDCM0469  CL76 PaTu 8988t C1766(0.99); C1769(0.99); C1483(0.95); C1858(0.97)  LDD1348  [6]
 LDCM0470  CL77 PaTu 8988t C1766(0.87); C1769(0.87); C1483(0.86); C1858(0.86)  LDD1349  [6]
 LDCM0471  CL78 PaTu 8988t C1766(0.75); C1769(0.75); C1483(0.79); C1858(1.17)  LDD1350  [6]
 LDCM0472  CL79 PaTu 8988t C1766(1.06); C1769(1.06); C1483(0.87); C1858(1.11)  LDD1351  [6]
 LDCM0473  CL8 PaTu 8988t C1766(0.88); C1769(0.95); C1483(0.82); C1858(2.09)  LDD1352  [6]
 LDCM0474  CL80 PaTu 8988t C1766(0.91); C1769(0.91); C1483(1.00); C1858(1.26)  LDD1353  [6]
 LDCM0475  CL81 PaTu 8988t C1766(0.74); C1769(0.74); C1483(0.71); C1858(1.10)  LDD1354  [6]
 LDCM0476  CL82 PaTu 8988t C1766(0.89); C1769(0.89); C1483(0.83); C1858(1.40)  LDD1355  [6]
 LDCM0477  CL83 PaTu 8988t C1766(0.90); C1769(0.90); C1483(0.75); C1858(1.45)  LDD1356  [6]
 LDCM0478  CL84 PaTu 8988t C1766(0.58); C1769(0.58); C1483(0.61); C1858(1.06)  LDD1357  [6]
 LDCM0479  CL85 PaTu 8988t C1766(0.98); C1769(0.98); C1483(0.94); C1858(0.98)  LDD1358  [6]
 LDCM0480  CL86 PaTu 8988t C1766(0.81); C1769(0.81); C1483(1.12); C1858(1.29)  LDD1359  [6]
 LDCM0481  CL87 PaTu 8988t C1766(0.62); C1769(0.62); C1483(0.61); C1858(1.14)  LDD1360  [6]
 LDCM0482  CL88 PaTu 8988t C1766(0.70); C1769(0.70); C1483(0.75); C1858(1.04)  LDD1361  [6]
 LDCM0483  CL89 PaTu 8988t C1766(0.63); C1769(0.63); C1483(0.63); C1858(1.14)  LDD1362  [6]
 LDCM0484  CL9 PaTu 8988t C1766(0.54); C1769(0.66); C1483(0.77); C1858(1.49)  LDD1363  [6]
 LDCM0485  CL90 PaTu 8988t C1766(0.63); C1769(0.63); C1483(0.77); C1858(1.50)  LDD1364  [6]
 LDCM0486  CL91 PaTu 8988t C1650(0.72); C1645(0.72); C1858(1.22)  LDD1365  [6]
 LDCM0487  CL92 PaTu 8988t C1650(0.62); C1645(0.62); C1858(1.45)  LDD1366  [6]
 LDCM0488  CL93 PaTu 8988t C1650(0.73); C1645(0.73); C1858(1.28)  LDD1367  [6]
 LDCM0489  CL94 PaTu 8988t C1650(0.79); C1645(0.79); C1858(1.35)  LDD1368  [6]
 LDCM0490  CL95 PaTu 8988t C1650(0.66); C1645(0.66); C1858(2.03)  LDD1369  [6]
 LDCM0491  CL96 PaTu 8988t C1650(0.62); C1645(0.62); C1858(1.37)  LDD1370  [6]
 LDCM0492  CL97 PaTu 8988t C1650(0.71); C1645(0.71); C1858(1.34)  LDD1371  [6]
 LDCM0493  CL98 PaTu 8988t C1650(0.61); C1645(0.61); C1858(1.59)  LDD1372  [6]
 LDCM0494  CL99 PaTu 8988t C1650(0.65); C1645(0.65); C1858(1.55)  LDD1373  [6]
 LDCM0495  E2913 HEK-293T C197(1.03); C288(1.20); C1858(1.01); C1645(0.93)  LDD1698  [7]
 LDCM0468  Fragment33 PaTu 8988t C1766(0.89); C1769(0.89); C1779(0.80); C1782(0.80)  LDD1347  [6]
 LDCM0427  Fragment51 PaTu 8988t C1779(0.76); C1782(0.76); C1787(0.76); C1483(1.68)  LDD1306  [6]
 LDCM0022  KB02 HEK-293T C1858(0.95); C288(0.91)  LDD1492  [7]
 LDCM0023  KB03 Jurkat C288(4.81)  LDD0209  [2]
 LDCM0024  KB05 IGR37 C679(2.85)  LDD3314  [8]

References

1 Labeling Preferences of Diazirines with Protein Biomolecules. J Am Chem Soc. 2021 May 5;143(17):6691-6700. doi: 10.1021/jacs.1c02509. Epub 2021 Apr 20.
Mass spectrometry data entry: PXD025140
2 Covalent Inhibition by a Natural Product-Inspired Latent Electrophile. J Am Chem Soc. 2023 May 24;145(20):11097-11109. doi: 10.1021/jacs.3c00598. Epub 2023 May 15.
3 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
4 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
5 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
6 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
7 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
8 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840