Details of the Target

General Information of Target

Target ID LDTP07645
Target Name Kelch-like protein 24 (KLHL24)
Gene Name KLHL24
Gene ID 54800
Synonyms
DRE1; Kelch-like protein 24; Kainate receptor-interacting protein for GluR6; KRIP6; Protein DRE1
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MVLILGRRLNREDLGVRDSPATKRKVFEMDPKSLTGHEFFDFSSGSSHAENILQIFNEFR
DSRLFTDVIICVEGKEFPCHRAVLSACSSYFRAMFCNDHRESREMLVEINGILAEAMECF
LQYVYTGKVKITTENVQYLFETSSLFQISVLRDACAKFLEEQLDPCNCLGIQRFADTHSL
KTLFTKCKNFALQTFEDVSQHEEFLELDKDELIDYICSDELVIGKEEMVFEAVMRWVYRA
VDLRRPLLHELLTHVRLPLLHPNYFVQTVEVDQLIQNSPECYQLLHEARRYHILGNEMMS
PRTRPRRSTGYSEVIVVVGGCERVGGFNLPYTECYDPVTGEWKSLAKLPEFTKSEYAVCA
LRNDILVSGGRINSRDVWIYNSQLNIWIRVASLNKGRWRHKMAVLLGKVYVVGGYDGQNR
LSSVECYDSFSNRWTEVAPLKEAVSSPAVTSCVGKLFVIGGGPDDNTCSDKVQSYDPETN
SWLLRAAIPIAKRCITAVSLNNLIYVAGGLTKAIYCYDPVEDYWMHVQNTFSRQENCGMS
VCNGKIYILGGRRENGEATDTILCYDPATSIITGVAAMPRPVSYHGCVTIHRYNEKCFKL
Target Bioclass
Other
Subcellular location
Perikaryon
Function
Necessary to maintain the balance between intermediate filament stability and degradation, a process that is essential for skin integrity. As part of the BCR(KLHL24) E3 ubiquitin ligase complex, mediates ubiquitination of KRT14 and controls its levels during keratinocytes differentiation. Specifically reduces kainate receptor-mediated currents in hippocampal neurons, most probably by modulating channel properties. Has a crucial role in cardiac development and function.
Uniprot ID
Q6TFL4
Ensemble ID
ENST00000242810.11
HGNC ID
HGNC:25947

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
A431 SNV: p.E104K .
IGROV1 Deletion: p.F27LfsTer8 DBIA    Probe Info 
LS180 SNV: p.G550D .
MCC13 SNV: p.E161K .
PC9 SNV: p.R11I .
SHP77 SNV: p.W378R .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C494(1.26)  LDD3331  [1]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 PaTu 8988t C537(0.96); C542(0.96)  LDD1093  [2]
 LDCM0215  AC10 HEK-293T C96(1.08)  LDD0813  [2]
 LDCM0216  AC100 HEK-293T C537(1.20); C96(1.15)  LDD0814  [2]
 LDCM0217  AC101 HEK-293T C537(1.01); C96(0.96)  LDD0815  [2]
 LDCM0218  AC102 HEK-293T C537(1.18); C96(1.27)  LDD0816  [2]
 LDCM0219  AC103 HEK-293T C537(1.42); C96(1.34)  LDD0817  [2]
 LDCM0220  AC104 HEK-293T C537(1.19); C96(1.21)  LDD0818  [2]
 LDCM0221  AC105 HEK-293T C537(1.04); C96(0.94)  LDD0819  [2]
 LDCM0222  AC106 HEK-293T C537(0.83); C96(0.90)  LDD0820  [2]
 LDCM0223  AC107 HEK-293T C537(1.26); C96(1.08)  LDD0821  [2]
 LDCM0224  AC108 HEK-293T C537(0.98); C96(0.90)  LDD0822  [2]
 LDCM0225  AC109 HEK-293T C537(1.04); C96(1.13)  LDD0823  [2]
 LDCM0226  AC11 HEK-293T C96(0.95)  LDD0824  [2]
 LDCM0227  AC110 HEK-293T C537(1.43); C96(1.51)  LDD0825  [2]
 LDCM0228  AC111 HEK-293T C537(1.51); C96(1.77)  LDD0826  [2]
 LDCM0229  AC112 HEK-293T C537(1.40); C96(1.77)  LDD0827  [2]
 LDCM0237  AC12 HEK-293T C96(1.04)  LDD0835  [2]
 LDCM0246  AC128 HEK-293T C537(1.03)  LDD0844  [2]
 LDCM0247  AC129 HEK-293T C537(1.37)  LDD0845  [2]
 LDCM0249  AC130 HEK-293T C537(0.95)  LDD0847  [2]
 LDCM0250  AC131 HEK-293T C537(0.97)  LDD0848  [2]
 LDCM0251  AC132 HEK-293T C537(1.07)  LDD0849  [2]
 LDCM0252  AC133 HEK-293T C537(1.17)  LDD0850  [2]
 LDCM0253  AC134 HEK-293T C537(1.24)  LDD0851  [2]
 LDCM0254  AC135 HEK-293T C537(1.26)  LDD0852  [2]
 LDCM0255  AC136 HEK-293T C537(1.18)  LDD0853  [2]
 LDCM0256  AC137 HEK-293T C537(1.33)  LDD0854  [2]
 LDCM0257  AC138 HEK-293T C537(1.49)  LDD0855  [2]
 LDCM0258  AC139 HEK-293T C537(1.22)  LDD0856  [2]
 LDCM0259  AC14 HEK-293T C96(1.14)  LDD0857  [2]
 LDCM0260  AC140 HEK-293T C537(1.15)  LDD0858  [2]
 LDCM0261  AC141 HEK-293T C537(1.41)  LDD0859  [2]
 LDCM0262  AC142 HEK-293T C537(1.23)  LDD0860  [2]
 LDCM0263  AC143 HEK-293T C537(1.36)  LDD0861  [2]
 LDCM0264  AC144 HEK-293T C537(1.36)  LDD0862  [2]
 LDCM0265  AC145 HEK-293T C537(1.43)  LDD0863  [2]
 LDCM0266  AC146 HEK-293T C537(1.47)  LDD0864  [2]
 LDCM0267  AC147 HEK-293T C537(1.54)  LDD0865  [2]
 LDCM0268  AC148 HEK-293T C537(1.35)  LDD0866  [2]
 LDCM0269  AC149 HEK-293T C537(1.65)  LDD0867  [2]
 LDCM0270  AC15 HEK-293T C96(1.74)  LDD0868  [2]
 LDCM0271  AC150 HEK-293T C537(2.26)  LDD0869  [2]
 LDCM0272  AC151 HEK-293T C537(1.32)  LDD0870  [2]
 LDCM0273  AC152 HEK-293T C537(1.28)  LDD0871  [2]
 LDCM0274  AC153 HEK-293T C537(1.26)  LDD0872  [2]
 LDCM0621  AC154 HEK-293T C537(1.15)  LDD2162  [2]
 LDCM0622  AC155 HEK-293T C537(2.11)  LDD2163  [2]
 LDCM0623  AC156 HEK-293T C537(1.30)  LDD2164  [2]
 LDCM0624  AC157 HEK-293T C537(1.26)  LDD2165  [2]
 LDCM0276  AC17 HEK-293T C542(1.65)  LDD0874  [2]
 LDCM0277  AC18 HEK-293T C542(1.20)  LDD0875  [2]
 LDCM0278  AC19 HEK-293T C542(1.08)  LDD0876  [2]
 LDCM0279  AC2 PaTu 8988t C537(1.18); C542(1.18)  LDD1158  [2]
 LDCM0280  AC20 HEK-293T C542(1.28)  LDD0878  [2]
 LDCM0281  AC21 HEK-293T C542(1.11)  LDD0879  [2]
 LDCM0282  AC22 HEK-293T C542(1.32)  LDD0880  [2]
 LDCM0283  AC23 HEK-293T C542(1.36)  LDD0881  [2]
 LDCM0284  AC24 HEK-293T C542(1.25)  LDD0882  [2]
 LDCM0285  AC25 HEK-293T C537(1.06); C96(1.13)  LDD0883  [2]
 LDCM0286  AC26 HEK-293T C537(1.25); C96(0.62)  LDD0884  [2]
 LDCM0287  AC27 HEK-293T C537(1.16); C96(0.62)  LDD0885  [2]
 LDCM0288  AC28 HEK-293T C537(1.56); C96(0.71)  LDD0886  [2]
 LDCM0289  AC29 HEK-293T C537(1.20); C96(1.17)  LDD0887  [2]
 LDCM0290  AC3 PaTu 8988t C537(1.00); C542(1.00)  LDD1169  [2]
 LDCM0291  AC30 HEK-293T C537(1.10); C96(0.98)  LDD0889  [2]
 LDCM0292  AC31 HEK-293T C537(0.88); C96(0.70)  LDD0890  [2]
 LDCM0293  AC32 HEK-293T C537(1.07); C96(0.73)  LDD0891  [2]
 LDCM0294  AC33 HEK-293T C537(1.05); C96(0.81)  LDD0892  [2]
 LDCM0295  AC34 HEK-293T C537(1.04); C96(1.08)  LDD0893  [2]
 LDCM0296  AC35 HEK-293T C494(0.93)  LDD1535  [3]
 LDCM0297  AC36 HEK-293T C494(1.03); C321(1.07)  LDD1536  [3]
 LDCM0298  AC37 HEK-293T C494(1.06)  LDD1537  [3]
 LDCM0299  AC38 HEK-293T C494(0.97)  LDD1538  [3]
 LDCM0300  AC39 HEK-293T C494(0.92); C321(0.84)  LDD1539  [3]
 LDCM0301  AC4 PaTu 8988t C537(1.23); C542(1.23)  LDD1180  [2]
 LDCM0302  AC40 HEK-293T C494(0.87)  LDD1541  [3]
 LDCM0303  AC41 HEK-293T C494(0.92)  LDD1542  [3]
 LDCM0304  AC42 HEK-293T C494(0.99)  LDD1543  [3]
 LDCM0305  AC43 HEK-293T C494(1.15)  LDD1544  [3]
 LDCM0306  AC44 HEK-293T C494(1.13); C321(1.11)  LDD1545  [3]
 LDCM0307  AC45 HEK-293T C494(0.99)  LDD1546  [3]
 LDCM0308  AC46 HEK-293T C537(1.34)  LDD0906  [2]
 LDCM0309  AC47 HEK-293T C537(1.38)  LDD0907  [2]
 LDCM0310  AC48 HEK-293T C537(1.38)  LDD0908  [2]
 LDCM0311  AC49 HEK-293T C537(1.21)  LDD0909  [2]
 LDCM0312  AC5 PaTu 8988t C537(1.03); C542(1.03)  LDD1191  [2]
 LDCM0313  AC50 HEK-293T C537(1.32)  LDD0911  [2]
 LDCM0314  AC51 HEK-293T C537(1.59)  LDD0912  [2]
 LDCM0315  AC52 HEK-293T C537(1.33)  LDD0913  [2]
 LDCM0316  AC53 HEK-293T C537(1.36)  LDD0914  [2]
 LDCM0317  AC54 HEK-293T C537(1.81)  LDD0915  [2]
 LDCM0318  AC55 HEK-293T C537(1.52)  LDD0916  [2]
 LDCM0319  AC56 HEK-293T C537(1.56)  LDD0917  [2]
 LDCM0320  AC57 HEK-293T C542(0.91); C96(0.85)  LDD0918  [2]
 LDCM0321  AC58 HEK-293T C542(1.00); C96(0.75)  LDD0919  [2]
 LDCM0322  AC59 HEK-293T C542(1.08); C96(0.74)  LDD0920  [2]
 LDCM0323  AC6 HEK-293T C96(0.90)  LDD0921  [2]
 LDCM0324  AC60 HEK-293T C542(1.14); C96(0.63)  LDD0922  [2]
 LDCM0325  AC61 HEK-293T C542(1.26); C96(0.83)  LDD0923  [2]
 LDCM0326  AC62 HEK-293T C542(0.97); C96(0.57)  LDD0924  [2]
 LDCM0327  AC63 HEK-293T C542(0.99); C96(0.76)  LDD0925  [2]
 LDCM0328  AC64 HEK-293T C542(1.02); C96(0.64)  LDD0926  [2]
 LDCM0329  AC65 HEK-293T C542(0.94); C96(0.90)  LDD0927  [2]
 LDCM0330  AC66 HEK-293T C542(0.92); C96(0.63)  LDD0928  [2]
 LDCM0331  AC67 HEK-293T C542(1.13); C96(0.86)  LDD0929  [2]
 LDCM0332  AC68 HEK-293T C537(1.07); C96(1.23)  LDD0930  [2]
 LDCM0333  AC69 HEK-293T C537(1.20); C96(1.17)  LDD0931  [2]
 LDCM0334  AC7 HEK-293T C96(1.23)  LDD0932  [2]
 LDCM0335  AC70 HEK-293T C537(1.22); C96(1.44)  LDD0933  [2]
 LDCM0336  AC71 HEK-293T C537(1.02); C96(1.31)  LDD0934  [2]
 LDCM0337  AC72 HEK-293T C537(1.40); C96(1.88)  LDD0935  [2]
 LDCM0338  AC73 HEK-293T C537(1.33); C96(1.54)  LDD0936  [2]
 LDCM0339  AC74 HEK-293T C537(1.49); C96(1.55)  LDD0937  [2]
 LDCM0340  AC75 HEK-293T C537(1.25); C96(1.95)  LDD0938  [2]
 LDCM0341  AC76 HEK-293T C537(1.35); C96(1.42)  LDD0939  [2]
 LDCM0342  AC77 HEK-293T C537(1.28); C96(1.52)  LDD0940  [2]
 LDCM0343  AC78 HEK-293T C537(1.41); C96(1.26)  LDD0941  [2]
 LDCM0344  AC79 HEK-293T C537(1.04); C96(1.31)  LDD0942  [2]
 LDCM0345  AC8 HEK-293T C96(1.59)  LDD0943  [2]
 LDCM0346  AC80 HEK-293T C537(1.21); C96(2.27)  LDD0944  [2]
 LDCM0347  AC81 HEK-293T C537(2.47); C96(1.69)  LDD0945  [2]
 LDCM0348  AC82 HEK-293T C537(1.54); C96(2.10)  LDD0946  [2]
 LDCM0349  AC83 HEK-293T C537(1.17); C542(1.07); C96(1.07)  LDD0947  [2]
 LDCM0350  AC84 HEK-293T C537(1.28); C542(1.45); C96(0.99)  LDD0948  [2]
 LDCM0351  AC85 HEK-293T C537(1.80); C542(1.45); C96(0.97)  LDD0949  [2]
 LDCM0352  AC86 HEK-293T C537(1.16); C542(1.06); C96(1.51)  LDD0950  [2]
 LDCM0353  AC87 HEK-293T C537(1.17); C542(1.37); C96(2.13)  LDD0951  [2]
 LDCM0354  AC88 HEK-293T C537(1.39); C542(1.42); C96(1.17)  LDD0952  [2]
 LDCM0355  AC89 HEK-293T C537(1.16); C542(1.53); C96(1.43)  LDD0953  [2]
 LDCM0357  AC90 HEK-293T C537(1.01); C542(1.56); C96(1.88)  LDD0955  [2]
 LDCM0358  AC91 HEK-293T C537(0.85); C542(1.21); C96(1.45)  LDD0956  [2]
 LDCM0359  AC92 HEK-293T C537(1.18); C542(1.17); C96(1.54)  LDD0957  [2]
 LDCM0360  AC93 HEK-293T C537(2.32); C542(1.32); C96(2.31)  LDD0958  [2]
 LDCM0361  AC94 HEK-293T C537(1.76); C542(1.25); C96(1.17)  LDD0959  [2]
 LDCM0362  AC95 HEK-293T C537(1.29); C542(1.47); C96(1.10)  LDD0960  [2]
 LDCM0363  AC96 HEK-293T C537(1.49); C542(1.54); C96(1.47)  LDD0961  [2]
 LDCM0364  AC97 HEK-293T C537(1.67); C542(2.24); C96(2.47)  LDD0962  [2]
 LDCM0365  AC98 HEK-293T C537(1.03); C96(0.90)  LDD0963  [2]
 LDCM0366  AC99 HEK-293T C537(1.17); C96(0.86)  LDD0964  [2]
 LDCM0248  AKOS034007472 HEK-293T C96(1.21)  LDD0846  [2]
 LDCM0356  AKOS034007680 HEK-293T C96(1.29)  LDD0954  [2]
 LDCM0275  AKOS034007705 HEK-293T C96(1.23)  LDD0873  [2]
 LDCM0367  CL1 PaTu 8988t C537(0.82); C542(0.82)  LDD1246  [2]
 LDCM0368  CL10 PaTu 8988t C537(0.83); C542(0.83)  LDD1247  [2]
 LDCM0369  CL100 PaTu 8988t C537(1.01); C542(1.01)  LDD1248  [2]
 LDCM0370  CL101 HEK-293T C96(1.40)  LDD0968  [2]
 LDCM0371  CL102 HEK-293T C96(1.25)  LDD0969  [2]
 LDCM0372  CL103 HEK-293T C96(1.22)  LDD0970  [2]
 LDCM0373  CL104 HEK-293T C96(1.48)  LDD0971  [2]
 LDCM0374  CL105 HEK-293T C542(1.14)  LDD0972  [2]
 LDCM0375  CL106 HEK-293T C542(0.93)  LDD0973  [2]
 LDCM0376  CL107 HEK-293T C542(0.95)  LDD0974  [2]
 LDCM0377  CL108 HEK-293T C542(0.98)  LDD0975  [2]
 LDCM0378  CL109 HEK-293T C542(0.82)  LDD0976  [2]
 LDCM0379  CL11 PaTu 8988t C537(0.90); C542(0.90)  LDD1258  [2]
 LDCM0380  CL110 HEK-293T C542(1.03)  LDD0978  [2]
 LDCM0381  CL111 HEK-293T C542(1.23)  LDD0979  [2]
 LDCM0382  CL112 HEK-293T C537(0.97); C96(0.90)  LDD0980  [2]
 LDCM0383  CL113 HEK-293T C537(0.99); C96(0.77)  LDD0981  [2]
 LDCM0384  CL114 HEK-293T C537(1.27); C96(1.00)  LDD0982  [2]
 LDCM0385  CL115 HEK-293T C537(1.14); C96(1.26)  LDD0983  [2]
 LDCM0386  CL116 HEK-293T C537(1.32); C96(1.19)  LDD0984  [2]
 LDCM0387  CL117 HEK-293T C494(0.97)  LDD1591  [3]
 LDCM0388  CL118 HEK-293T C494(1.10)  LDD1592  [3]
 LDCM0389  CL119 HEK-293T C494(1.02)  LDD1593  [3]
 LDCM0390  CL12 PaTu 8988t C537(1.09); C542(1.09)  LDD1269  [2]
 LDCM0391  CL120 HEK-293T C494(0.91)  LDD1595  [3]
 LDCM0392  CL121 HEK-293T C537(1.56)  LDD0990  [2]
 LDCM0393  CL122 HEK-293T C537(1.71)  LDD0991  [2]
 LDCM0394  CL123 HEK-293T C537(1.29)  LDD0992  [2]
 LDCM0395  CL124 HEK-293T C537(1.32)  LDD0993  [2]
 LDCM0396  CL125 HEK-293T C542(0.85); C96(0.80)  LDD0994  [2]
 LDCM0397  CL126 HEK-293T C542(0.89); C96(0.60)  LDD0995  [2]
 LDCM0398  CL127 HEK-293T C542(0.77); C96(0.80)  LDD0996  [2]
 LDCM0399  CL128 HEK-293T C542(0.75); C96(0.85)  LDD0997  [2]
 LDCM0400  CL13 PaTu 8988t C537(0.97); C542(0.97)  LDD1279  [2]
 LDCM0401  CL14 PaTu 8988t C537(1.00); C542(1.00)  LDD1280  [2]
 LDCM0402  CL15 PaTu 8988t C537(1.24); C542(1.24)  LDD1281  [2]
 LDCM0403  CL16 HEK-293T C537(0.85)  LDD1001  [2]
 LDCM0404  CL17 HEK-293T C537(1.51)  LDD1002  [2]
 LDCM0405  CL18 HEK-293T C537(1.13)  LDD1003  [2]
 LDCM0406  CL19 HEK-293T C537(1.15)  LDD1004  [2]
 LDCM0407  CL2 PaTu 8988t C537(1.03); C542(1.03)  LDD1286  [2]
 LDCM0408  CL20 HEK-293T C537(1.01)  LDD1006  [2]
 LDCM0409  CL21 HEK-293T C537(1.24)  LDD1007  [2]
 LDCM0410  CL22 HEK-293T C537(0.98)  LDD1008  [2]
 LDCM0411  CL23 HEK-293T C537(1.11)  LDD1009  [2]
 LDCM0412  CL24 HEK-293T C537(1.03)  LDD1010  [2]
 LDCM0413  CL25 HEK-293T C537(1.10)  LDD1011  [2]
 LDCM0414  CL26 HEK-293T C537(1.21)  LDD1012  [2]
 LDCM0415  CL27 HEK-293T C537(1.15)  LDD1013  [2]
 LDCM0416  CL28 HEK-293T C537(1.26)  LDD1014  [2]
 LDCM0417  CL29 HEK-293T C537(1.20)  LDD1015  [2]
 LDCM0418  CL3 PaTu 8988t C537(1.27); C542(1.27)  LDD1297  [2]
 LDCM0419  CL30 HEK-293T C537(1.37)  LDD1017  [2]
 LDCM0420  CL31 PaTu 8988t C537(0.77); C542(0.77)  LDD1299  [2]
 LDCM0421  CL32 PaTu 8988t C537(0.87); C542(0.87)  LDD1300  [2]
 LDCM0422  CL33 PaTu 8988t C537(0.85); C542(0.85)  LDD1301  [2]
 LDCM0423  CL34 PaTu 8988t C537(0.95); C542(0.95)  LDD1302  [2]
 LDCM0424  CL35 PaTu 8988t C537(0.84); C542(0.84)  LDD1303  [2]
 LDCM0425  CL36 PaTu 8988t C537(1.20); C542(1.20)  LDD1304  [2]
 LDCM0426  CL37 PaTu 8988t C537(0.79); C542(0.79)  LDD1305  [2]
 LDCM0428  CL39 PaTu 8988t C537(0.80); C542(0.80)  LDD1307  [2]
 LDCM0429  CL4 PaTu 8988t C537(1.38); C542(1.38)  LDD1308  [2]
 LDCM0430  CL40 PaTu 8988t C537(1.04); C542(1.04)  LDD1309  [2]
 LDCM0431  CL41 PaTu 8988t C537(0.79); C542(0.79)  LDD1310  [2]
 LDCM0432  CL42 PaTu 8988t C537(0.70); C542(0.70)  LDD1311  [2]
 LDCM0433  CL43 PaTu 8988t C537(0.85); C542(0.85)  LDD1312  [2]
 LDCM0434  CL44 PaTu 8988t C537(0.86); C542(0.86)  LDD1313  [2]
 LDCM0435  CL45 PaTu 8988t C537(0.77); C542(0.77)  LDD1314  [2]
 LDCM0436  CL46 HEK-293T C537(0.91); C542(1.17); C96(1.51)  LDD1034  [2]
 LDCM0437  CL47 HEK-293T C537(0.92); C542(1.02); C96(1.24)  LDD1035  [2]
 LDCM0438  CL48 HEK-293T C537(0.92); C542(1.12); C96(1.32)  LDD1036  [2]
 LDCM0439  CL49 HEK-293T C537(1.16); C542(0.95); C96(1.46)  LDD1037  [2]
 LDCM0440  CL5 PaTu 8988t C537(1.01); C542(1.01)  LDD1319  [2]
 LDCM0441  CL50 HEK-293T C537(1.34); C542(1.38); C96(1.87)  LDD1039  [2]
 LDCM0442  CL51 HEK-293T C537(1.19); C542(0.82); C96(1.02)  LDD1040  [2]
 LDCM0443  CL52 HEK-293T C537(0.89); C542(0.88); C96(1.01)  LDD1041  [2]
 LDCM0444  CL53 HEK-293T C537(0.88); C542(0.93); C96(1.17)  LDD1042  [2]
 LDCM0445  CL54 HEK-293T C537(1.16); C542(0.81); C96(1.12)  LDD1043  [2]
 LDCM0446  CL55 HEK-293T C537(1.15); C542(1.05); C96(1.48)  LDD1044  [2]
 LDCM0447  CL56 HEK-293T C537(0.85); C542(1.11); C96(0.84)  LDD1045  [2]
 LDCM0448  CL57 HEK-293T C537(1.02); C542(1.16); C96(1.29)  LDD1046  [2]
 LDCM0449  CL58 HEK-293T C537(1.17); C542(0.90); C96(1.22)  LDD1047  [2]
 LDCM0450  CL59 HEK-293T C537(1.23); C542(1.13); C96(1.61)  LDD1048  [2]
 LDCM0451  CL6 PaTu 8988t C537(0.90); C542(0.90)  LDD1330  [2]
 LDCM0452  CL60 HEK-293T C537(1.26); C542(1.17); C96(1.98)  LDD1050  [2]
 LDCM0453  CL61 HEK-293T C542(1.10); C96(1.05)  LDD1051  [2]
 LDCM0454  CL62 HEK-293T C542(1.38); C96(1.15)  LDD1052  [2]
 LDCM0455  CL63 HEK-293T C542(1.45); C96(1.23)  LDD1053  [2]
 LDCM0456  CL64 HEK-293T C542(1.35); C96(0.99)  LDD1054  [2]
 LDCM0457  CL65 HEK-293T C542(1.38); C96(1.04)  LDD1055  [2]
 LDCM0458  CL66 HEK-293T C542(1.47); C96(1.04)  LDD1056  [2]
 LDCM0459  CL67 HEK-293T C542(1.37); C96(0.97)  LDD1057  [2]
 LDCM0460  CL68 HEK-293T C542(1.07); C96(0.84)  LDD1058  [2]
 LDCM0461  CL69 HEK-293T C542(0.99); C96(0.93)  LDD1059  [2]
 LDCM0462  CL7 PaTu 8988t C537(1.04); C542(1.04)  LDD1341  [2]
 LDCM0463  CL70 HEK-293T C542(0.98); C96(0.84)  LDD1061  [2]
 LDCM0464  CL71 HEK-293T C542(1.38); C96(1.13)  LDD1062  [2]
 LDCM0465  CL72 HEK-293T C542(0.95); C96(0.94)  LDD1063  [2]
 LDCM0466  CL73 HEK-293T C542(1.03); C96(0.82)  LDD1064  [2]
 LDCM0467  CL74 HEK-293T C542(1.78); C96(1.69)  LDD1065  [2]
 LDCM0469  CL76 HEK-293T C537(0.95)  LDD1067  [2]
 LDCM0470  CL77 HEK-293T C537(0.90)  LDD1068  [2]
 LDCM0471  CL78 HEK-293T C537(0.91)  LDD1069  [2]
 LDCM0472  CL79 HEK-293T C537(1.01)  LDD1070  [2]
 LDCM0473  CL8 PaTu 8988t C537(1.75); C542(1.75)  LDD1352  [2]
 LDCM0474  CL80 HEK-293T C537(1.27)  LDD1072  [2]
 LDCM0475  CL81 HEK-293T C537(1.24)  LDD1073  [2]
 LDCM0476  CL82 HEK-293T C537(1.23)  LDD1074  [2]
 LDCM0477  CL83 HEK-293T C537(1.03)  LDD1075  [2]
 LDCM0478  CL84 HEK-293T C537(0.81)  LDD1076  [2]
 LDCM0479  CL85 HEK-293T C537(1.50)  LDD1077  [2]
 LDCM0480  CL86 HEK-293T C537(2.17)  LDD1078  [2]
 LDCM0481  CL87 HEK-293T C537(1.25)  LDD1079  [2]
 LDCM0482  CL88 HEK-293T C537(1.09)  LDD1080  [2]
 LDCM0483  CL89 HEK-293T C537(1.06)  LDD1081  [2]
 LDCM0484  CL9 PaTu 8988t C537(1.06); C542(1.06)  LDD1363  [2]
 LDCM0485  CL90 HEK-293T C537(1.20)  LDD1083  [2]
 LDCM0486  CL91 PaTu 8988t C537(0.94); C542(0.94)  LDD1365  [2]
 LDCM0487  CL92 PaTu 8988t C537(0.75); C542(0.75)  LDD1366  [2]
 LDCM0488  CL93 PaTu 8988t C537(0.95); C542(0.95)  LDD1367  [2]
 LDCM0489  CL94 PaTu 8988t C537(1.01); C542(1.01)  LDD1368  [2]
 LDCM0490  CL95 PaTu 8988t C537(1.02); C542(1.02)  LDD1369  [2]
 LDCM0491  CL96 PaTu 8988t C537(1.02); C542(1.02)  LDD1370  [2]
 LDCM0492  CL97 PaTu 8988t C537(1.01); C542(1.01)  LDD1371  [2]
 LDCM0493  CL98 PaTu 8988t C537(0.87); C542(0.87)  LDD1372  [2]
 LDCM0494  CL99 PaTu 8988t C537(1.11); C542(1.11)  LDD1373  [2]
 LDCM0495  E2913 HEK-293T C494(1.07)  LDD1698  [3]
 LDCM0468  Fragment33 HEK-293T C542(1.43); C96(1.21)  LDD1066  [2]
 LDCM0427  Fragment51 PaTu 8988t C537(0.91); C542(0.91)  LDD1306  [2]
 LDCM0022  KB02 HEK-293T C468(1.10); C494(0.91)  LDD1492  [3]
 LDCM0023  KB03 HEK-293T C468(1.23); C494(0.83)  LDD1497  [3]
 LDCM0024  KB05 MKN-1 C494(1.26)  LDD3331  [1]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Other
Click To Hide/Show 3 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Kelch-like ECH-associated protein 1 (KEAP1) KEAP1 family Q14145
Cytoplasmic protein NCK2 (NCK2) . O43639
Kelch-like protein 12 (KLHL12) . Q53G59

References

1 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
2 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
3 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402