Details of the Target

General Information of Target

Target ID LDTP07601
Target Name DNA cross-link repair 1A protein (DCLRE1A)
Gene Name DCLRE1A
Gene ID 9937
Synonyms
KIAA0086; SNM1; SNM1A; DNA cross-link repair 1A protein; Beta-lactamase DCLRE1A; EC 3.5.2.6; SNM1 homolog A; hSNM1; hSNM1A
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MLEDISEEDIWEYKSKRKPKRVDPNNGSKNILKSVEKATDGKYQSKRSRNRKRAAEAKEV
KDHEVPLGNAGCQTSVASSQNSSCGDGIQQTQDKETTPGKLCRTQKSQHVSPKIRPVYDG
YCPNCQMPFSSLIGQTPRWHVFECLDSPPRSETECPDGLLCTSTIPFHYKRYTHFLLAQS
RAGDHPFSSPSPASGGSFSETKSGVLCSLEERWSSYQNQTDNSVSNDPLLMTQYFKKSPS
LTEASEKISTHIQTSQQALQFTDFVENDKLVGVALRLANNSEHINLPLPENDFSDCEISY
SPLQSDEDTHDIDEKPDDSQEQLFFTESSKDGSLEEDDDSCGFFKKRHGPLLKDQDESCP
KVNSFLTRDKYDEGLYRFNSLNDLSQPISQNNESTLPYDLACTGGDFVLFPPALAGKLAA
SVHQATKAKPDEPEFHSAQSNKQKQVIEESSVYNQVSLPLVKSLMLKPFESQVEGYLSSQ
PTQNTIRKLSSENLNAKNNTNSACFCRKALEGVPVGKATILNTENLSSTPAPKYLKILPS
GLKYNARHPSTKVMKQMDIGVYFGLPPKRKEEKLLGESALEGINLNPVPSPNQKRSSQCK
RKAEKSLSDLEFDASTLHESQLSVELSSERSQRQKKRCRKSNSLQEGACQKRSDHLINTE
SEAVNLSKVKVFTKSAHGGLQRGNKKIPESSNVGGSRKKTCPFYKKIPGTGFTVDAFQYG
VVEGCTAYFLTHFHSDHYAGLSKHFTFPVYCSEITGNLLKNKLHVQEQYIHPLPLDTECI
VNGVKVVLLDANHCPGAVMILFYLPNGTVILHTGDFRADPSMERSLLADQKVHMLYLDTT
YCSPEYTFPSQQEVIRFAINTAFEAVTLNPHALVVCGTYSIGKEKVFLAIADVLGSKVGM
SQEKYKTLQCLNIPEINSLITTDMCSSLVHLLPMMQINFKGLQSHLKKCGGKYNQILAFR
PTGWTHSNKFTRIADVIPQTKGNISIYGIPYSEHSSYLEMKRFVQWLKPQKIIPTVNVGT
WKSRSTMEKYFREWKLEAGY
Target Bioclass
Enzyme
Family
DNA repair metallo-beta-lactamase (DRMBL) family
Subcellular location
Nucleus
Function
May be required for DNA interstrand cross-link repair. Also required for checkpoint mediated cell cycle arrest in early prophase in response to mitotic spindle poisons. Possesses beta-lactamase activity, catalyzing the hydrolysis of penicillin G and nitrocefin. Exhibits no activity towards other beta-lactam antibiotic classes including cephalosporins (cefotaxime) and carbapenems (imipenem).
Uniprot ID
Q6PJP8
Ensemble ID
ENST00000361384.7
HGNC ID
HGNC:17660
ChEMBL ID
CHEMBL4105903

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 3 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
IA-alkyne
 Probe Info  		C506(4.13)  LDD2157  [1]
DBIA
 Probe Info  		C72(1.04); C84(1.04)  LDD0078  [2]
IPM
 Probe Info  		C506(0.00); C504(0.00)  LDD2156  [3]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HCT 116 C207(1.00)  LDD0531  [2]
 LDCM0215  AC10 HCT 116 C207(0.97)  LDD0532  [2]
 LDCM0226  AC11 HCT 116 C207(1.06)  LDD0543  [2]
 LDCM0230  AC113 HCT 116 C207(0.87)  LDD0547  [2]
 LDCM0231  AC114 HCT 116 C207(0.91)  LDD0548  [2]
 LDCM0232  AC115 HCT 116 C207(0.84)  LDD0549  [2]
 LDCM0233  AC116 HCT 116 C207(0.92)  LDD0550  [2]
 LDCM0234  AC117 HCT 116 C207(0.81)  LDD0551  [2]
 LDCM0235  AC118 HCT 116 C207(0.98)  LDD0552  [2]
 LDCM0236  AC119 HCT 116 C207(1.19)  LDD0553  [2]
 LDCM0237  AC12 HCT 116 C207(1.00)  LDD0554  [2]
 LDCM0238  AC120 HCT 116 C207(0.97)  LDD0555  [2]
 LDCM0239  AC121 HCT 116 C207(1.13)  LDD0556  [2]
 LDCM0240  AC122 HCT 116 C207(1.02)  LDD0557  [2]
 LDCM0241  AC123 HCT 116 C207(1.07)  LDD0558  [2]
 LDCM0242  AC124 HCT 116 C207(0.98)  LDD0559  [2]
 LDCM0243  AC125 HCT 116 C207(0.89)  LDD0560  [2]
 LDCM0244  AC126 HCT 116 C207(0.97)  LDD0561  [2]
 LDCM0245  AC127 HCT 116 C207(0.96)  LDD0562  [2]
 LDCM0259  AC14 HCT 116 C207(0.84)  LDD0576  [2]
 LDCM0270  AC15 HCT 116 C207(0.89)  LDD0587  [2]
 LDCM0276  AC17 HCT 116 C207(1.11)  LDD0593  [2]
 LDCM0277  AC18 HCT 116 C207(1.14)  LDD0594  [2]
 LDCM0278  AC19 HCT 116 C207(1.04)  LDD0595  [2]
 LDCM0279  AC2 HCT 116 C207(1.10)  LDD0596  [2]
 LDCM0280  AC20 HCT 116 C207(1.01)  LDD0597  [2]
 LDCM0281  AC21 HCT 116 C207(0.95)  LDD0598  [2]
 LDCM0282  AC22 HCT 116 C207(0.91)  LDD0599  [2]
 LDCM0283  AC23 HCT 116 C207(0.96)  LDD0600  [2]
 LDCM0284  AC24 HCT 116 C207(0.89)  LDD0601  [2]
 LDCM0285  AC25 HCT 116 C207(0.92)  LDD0602  [2]
 LDCM0286  AC26 HCT 116 C207(0.97)  LDD0603  [2]
 LDCM0287  AC27 HCT 116 C207(0.75)  LDD0604  [2]
 LDCM0288  AC28 HCT 116 C207(0.83)  LDD0605  [2]
 LDCM0289  AC29 HCT 116 C207(0.90)  LDD0606  [2]
 LDCM0290  AC3 HCT 116 C207(1.09)  LDD0607  [2]
 LDCM0291  AC30 HCT 116 C207(0.88)  LDD0608  [2]
 LDCM0292  AC31 HCT 116 C207(0.85)  LDD0609  [2]
 LDCM0293  AC32 HCT 116 C207(0.99)  LDD0610  [2]
 LDCM0294  AC33 HCT 116 C207(0.88)  LDD0611  [2]
 LDCM0295  AC34 HCT 116 C207(0.82)  LDD0612  [2]
 LDCM0297  AC36 HEK-293T C649(1.00)  LDD1536  [4]
 LDCM0299  AC38 HEK-293T C402(0.86)  LDD1538  [4]
 LDCM0300  AC39 HEK-293T C359(0.71); C402(1.25)  LDD1539  [4]
 LDCM0301  AC4 HCT 116 C207(1.15)  LDD0618  [2]
 LDCM0306  AC44 HEK-293T C649(1.06)  LDD1545  [4]
 LDCM0308  AC46 HEK-293T C402(0.81)  LDD1547  [4]
 LDCM0309  AC47 HEK-293T C359(1.68); C402(1.02)  LDD1548  [4]
 LDCM0312  AC5 HCT 116 C207(1.30)  LDD0629  [2]
 LDCM0315  AC52 HEK-293T C649(1.00)  LDD1554  [4]
 LDCM0317  AC54 HEK-293T C402(0.91)  LDD1556  [4]
 LDCM0318  AC55 HEK-293T C359(1.18); C402(0.87)  LDD1557  [4]
 LDCM0323  AC6 HCT 116 C207(1.05)  LDD0640  [2]
 LDCM0324  AC60 HEK-293T C649(1.04)  LDD1563  [4]
 LDCM0326  AC62 HEK-293T C402(0.92)  LDD1565  [4]
 LDCM0327  AC63 HEK-293T C359(0.82); C402(1.03)  LDD1566  [4]
 LDCM0334  AC7 HCT 116 C207(0.78)  LDD0651  [2]
 LDCM0345  AC8 HCT 116 C207(0.84)  LDD0662  [2]
 LDCM0349  AC83 HCT 116 C207(1.03)  LDD0666  [2]
 LDCM0350  AC84 HCT 116 C207(1.10)  LDD0667  [2]
 LDCM0351  AC85 HCT 116 C207(1.16)  LDD0668  [2]
 LDCM0352  AC86 HCT 116 C207(1.30)  LDD0669  [2]
 LDCM0353  AC87 HCT 116 C207(1.14)  LDD0670  [2]
 LDCM0354  AC88 HCT 116 C207(1.04)  LDD0671  [2]
 LDCM0355  AC89 HCT 116 C207(1.13)  LDD0672  [2]
 LDCM0357  AC90 HCT 116 C207(1.06)  LDD0674  [2]
 LDCM0358  AC91 HCT 116 C207(0.85)  LDD0675  [2]
 LDCM0359  AC92 HCT 116 C207(0.98)  LDD0676  [2]
 LDCM0360  AC93 HCT 116 C207(0.94)  LDD0677  [2]
 LDCM0361  AC94 HCT 116 C207(1.03)  LDD0678  [2]
 LDCM0362  AC95 HCT 116 C207(0.92)  LDD0679  [2]
 LDCM0363  AC96 HCT 116 C207(0.92)  LDD0680  [2]
 LDCM0364  AC97 HCT 116 C207(1.17)  LDD0681  [2]
 LDCM0248  AKOS034007472 HCT 116 C207(0.91)  LDD0565  [2]
 LDCM0356  AKOS034007680 HCT 116 C207(0.80)  LDD0673  [2]
 LDCM0275  AKOS034007705 HCT 116 C207(0.99)  LDD0592  [2]
 LDCM0020  ARS-1620 HCC44 C72(1.04); C84(1.04)  LDD0078  [2]
 LDCM0368  CL10 HEK-293T C402(0.84)  LDD1572  [4]
 LDCM0369  CL100 HCT 116 C207(0.71)  LDD0686  [2]
 LDCM0370  CL101 HCT 116 C207(0.65)  LDD0687  [2]
 LDCM0371  CL102 HCT 116 C207(0.72)  LDD0688  [2]
 LDCM0372  CL103 HCT 116 C207(0.81)  LDD0689  [2]
 LDCM0373  CL104 HCT 116 C207(0.86)  LDD0690  [2]
 LDCM0374  CL105 HCT 116 C207(1.15)  LDD0691  [2]
 LDCM0375  CL106 HCT 116 C207(1.48)  LDD0692  [2]
 LDCM0376  CL107 HCT 116 C207(1.24)  LDD0693  [2]
 LDCM0377  CL108 HCT 116 C207(1.17)  LDD0694  [2]
 LDCM0378  CL109 HCT 116 C207(1.01)  LDD0695  [2]
 LDCM0379  CL11 HEK-293T C359(1.25); C402(0.99)  LDD1583  [4]
 LDCM0380  CL110 HCT 116 C207(1.30)  LDD0697  [2]
 LDCM0381  CL111 HCT 116 C207(1.01)  LDD0698  [2]
 LDCM0382  CL112 HCT 116 C207(0.82)  LDD0699  [2]
 LDCM0383  CL113 HCT 116 C207(0.83)  LDD0700  [2]
 LDCM0384  CL114 HCT 116 C207(0.82)  LDD0701  [2]
 LDCM0385  CL115 HCT 116 C207(1.06)  LDD0702  [2]
 LDCM0386  CL116 HCT 116 C207(0.85)  LDD0703  [2]
 LDCM0391  CL120 HEK-293T C207(1.00)  LDD1595  [4]
 LDCM0395  CL124 HEK-293T C207(1.03)  LDD1599  [4]
 LDCM0399  CL128 HEK-293T C207(0.95)  LDD1603  [4]
 LDCM0403  CL16 HEK-293T C207(1.03)  LDD1607  [4]
 LDCM0408  CL20 HEK-293T C649(0.94)  LDD1612  [4]
 LDCM0410  CL22 HEK-293T C402(0.86)  LDD1614  [4]
 LDCM0411  CL23 HEK-293T C359(1.55); C402(1.07)  LDD1615  [4]
 LDCM0416  CL28 HEK-293T C207(0.90)  LDD1620  [4]
 LDCM0421  CL32 HEK-293T C649(1.01)  LDD1625  [4]
 LDCM0423  CL34 HEK-293T C402(0.95)  LDD1627  [4]
 LDCM0424  CL35 HEK-293T C359(1.55); C402(1.13)  LDD1628  [4]
 LDCM0429  CL4 HEK-293T C207(1.09)  LDD1633  [4]
 LDCM0430  CL40 HEK-293T C207(0.87)  LDD1634  [4]
 LDCM0434  CL44 HEK-293T C649(0.98)  LDD1638  [4]
 LDCM0436  CL46 HCT 116 C207(0.82)  LDD0753  [2]
 LDCM0437  CL47 HCT 116 C207(0.84)  LDD0754  [2]
 LDCM0438  CL48 HCT 116 C207(1.11)  LDD0755  [2]
 LDCM0439  CL49 HCT 116 C207(1.27)  LDD0756  [2]
 LDCM0441  CL50 HCT 116 C207(1.03)  LDD0758  [2]
 LDCM0442  CL51 HCT 116 C207(1.35)  LDD0759  [2]
 LDCM0443  CL52 HCT 116 C207(1.13)  LDD0760  [2]
 LDCM0444  CL53 HCT 116 C207(0.77)  LDD0761  [2]
 LDCM0445  CL54 HCT 116 C207(0.68)  LDD0762  [2]
 LDCM0446  CL55 HCT 116 C207(1.07)  LDD0763  [2]
 LDCM0447  CL56 HCT 116 C207(0.89)  LDD0764  [2]
 LDCM0448  CL57 HCT 116 C207(1.33)  LDD0765  [2]
 LDCM0449  CL58 HCT 116 C207(1.06)  LDD0766  [2]
 LDCM0450  CL59 HCT 116 C207(1.07)  LDD0767  [2]
 LDCM0452  CL60 HCT 116 C207(1.19)  LDD0769  [2]
 LDCM0456  CL64 HEK-293T C207(0.95)  LDD1659  [4]
 LDCM0460  CL68 HEK-293T C649(1.03)  LDD1663  [4]
 LDCM0463  CL70 HEK-293T C402(1.05)  LDD1666  [4]
 LDCM0464  CL71 HEK-293T C359(2.24); C402(1.14)  LDD1667  [4]
 LDCM0469  CL76 HCT 116 C207(1.04)  LDD0786  [2]
 LDCM0470  CL77 HCT 116 C207(0.84)  LDD0787  [2]
 LDCM0471  CL78 HCT 116 C207(0.95)  LDD0788  [2]
 LDCM0472  CL79 HCT 116 C207(1.09)  LDD0789  [2]
 LDCM0473  CL8 HEK-293T C649(0.93)  LDD1676  [4]
 LDCM0474  CL80 HCT 116 C207(1.13)  LDD0791  [2]
 LDCM0475  CL81 HCT 116 C207(0.95)  LDD0792  [2]
 LDCM0476  CL82 HCT 116 C207(0.85)  LDD0793  [2]
 LDCM0477  CL83 HCT 116 C207(0.99)  LDD0794  [2]
 LDCM0478  CL84 HCT 116 C207(0.82)  LDD0795  [2]
 LDCM0479  CL85 HCT 116 C207(0.89)  LDD0796  [2]
 LDCM0480  CL86 HCT 116 C207(0.92)  LDD0797  [2]
 LDCM0481  CL87 HCT 116 C207(0.85)  LDD0798  [2]
 LDCM0482  CL88 HCT 116 C207(0.92)  LDD0799  [2]
 LDCM0483  CL89 HCT 116 C207(1.00)  LDD0800  [2]
 LDCM0485  CL90 HCT 116 C207(0.77)  LDD0802  [2]
 LDCM0486  CL91 HCT 116 C207(0.72)  LDD0803  [2]
 LDCM0487  CL92 HCT 116 C207(0.88)  LDD0804  [2]
 LDCM0488  CL93 HCT 116 C207(1.14)  LDD0805  [2]
 LDCM0489  CL94 HCT 116 C207(1.06)  LDD0806  [2]
 LDCM0490  CL95 HCT 116 C207(0.95)  LDD0807  [2]
 LDCM0491  CL96 HCT 116 C207(0.96)  LDD0808  [2]
 LDCM0492  CL97 HCT 116 C207(0.98)  LDD0809  [2]
 LDCM0493  CL98 HCT 116 C207(0.91)  LDD0810  [2]
 LDCM0494  CL99 HCT 116 C207(1.02)  LDD0811  [2]
 LDCM0022  KB02 HEK-293T C359(0.90)  LDD1492  [4]
 LDCM0023  KB03 HEK-293T C359(0.92)  LDD1497  [4]
 LDCM0024  KB05 HEK-293T C359(0.79)  LDD1502  [4]
 LDCM0021  THZ1 HCT 116 C504(1.14); C506(1.14); C72(1.11); C84(1.11)  LDD2173  [2]

References

1 From chemoproteomic-detected amino acids to genomic coordinates: insights into precise multi-omic data integration. Mol Syst Biol. 2021 Feb;17(2):e9840. doi: 10.15252/msb.20209840.
Mass spectrometry data entry: PXD022151
2 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
3 Benchmarking Cleavable Biotin Tags for Peptide-Centric Chemoproteomics. J Proteome Res. 2022 May 6;21(5):1349-1358. doi: 10.1021/acs.jproteome.2c00174. Epub 2022 Apr 25.
Mass spectrometry data entry: PXD031019
4 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402