Details of the Target

General Information of Target

Target ID LDTP07354
Target Name Scavenger receptor class A member 3 (SCARA3)
Gene Name SCARA3
Gene ID 51435
Synonyms
CSR; Scavenger receptor class A member 3; Cellular stress response gene protein
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MKVRSAGGDGDALCVTEEDLAGDDEDMPTFPCTQKGRPGPRCSRCQKNLSLHTSVRILYL
FLALLLVAVAVLASLVFRKVDSLSEDISLTQSIYDKKLVLMQKNLQGLDPKALNNCSFCH
EAGQLGPEIRKLQEELEGIQKLLLAQEVQLDQTLQAQEVLSTTSRQISQEMGSCSFSIHQ
VNQSLGLFLAQVRGWQATTAGLDLSLKDLTQECYDVKAAVHQINFTVGQTSEWIHGIQRK
TDEETLTLQKIVTDWQNYTRLFSGLRTTSTKTGEAVKNIQATLGASSQRISQNSESMHDL
VLQVMGLQLQLDNISSFLDDHEENMHDLQYHTHYAQNRTVERFESLEGRMASHEIEIGTI
FTNINATDNHVHSMLKYLDDVRLSCTLGFHTHAEELYYLNKSVSIMLGTTDLLRERFSLL
SARLDLNVRNLSMIVEEMKAVDTQHGEILRNVTILRGAPGPPGPRGFKGDMGVKGPVGGR
GPKGDPGSLGPLGPQGPQGQPGEAGPVGERGPVGPRGFPGLKGSKGSFGTGGPRGQPGPK
GDIGPPGPEGPPGSPGPSGPQGKPGIAGKTGSPGQRGAMGPKGEPGIQGPPGLPGPPGPP
GSQSFY
Target Bioclass
Other
Subcellular location
Endoplasmic reticulum membrane
Function Seems to protect cells by scavenging oxidative molecules or harmful products of oxidation.
Uniprot ID
Q6AZY7
Ensemble ID
ENST00000301904.4
HGNC ID
HGNC:19000

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
AN3CA SNV: p.M350V .
CAL148 SNV: p.S345C .
CORL23 SNV: p.T282A .
HCT15 SNV: p.V76F .
MCC13 SNV: p.S294L .
MDST8 SNV: p.V371G .
MFE319 SNV: p.L419Q .
REH SNV: p.G10R .
RKO SNV: p.D95G .
SKMEL2 SNV: p.S527N .
SNGM SNV: p.T570I .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 2 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C14(0.87); C32(0.87)  LDD0531  [1]
Methacrolein
 Probe Info  		N.A.  LDD0218  [2]
PAL-AfBPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C170
 Probe Info  		10.06  LDD1850  [3]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HCT 116 C14(0.87); C32(0.87)  LDD0531  [1]
 LDCM0216  AC100 HCT 116 C14(0.83); C32(0.83)  LDD0533  [1]
 LDCM0217  AC101 HCT 116 C14(0.82); C32(0.82)  LDD0534  [1]
 LDCM0218  AC102 HCT 116 C14(0.94); C32(0.94)  LDD0535  [1]
 LDCM0219  AC103 HCT 116 C14(1.06); C32(1.06)  LDD0536  [1]
 LDCM0220  AC104 HCT 116 C14(1.05); C32(1.05)  LDD0537  [1]
 LDCM0221  AC105 HCT 116 C14(0.97); C32(0.97)  LDD0538  [1]
 LDCM0222  AC106 HCT 116 C14(0.91); C32(0.91)  LDD0539  [1]
 LDCM0223  AC107 HCT 116 C14(0.96); C32(0.73)  LDD0540  [1]
 LDCM0224  AC108 HCT 116 C14(0.82); C32(1.04)  LDD0541  [1]
 LDCM0225  AC109 HCT 116 C14(0.86); C32(1.10)  LDD0542  [1]
 LDCM0227  AC110 HCT 116 C14(0.98); C32(1.01)  LDD0544  [1]
 LDCM0228  AC111 HCT 116 C14(1.01); C32(0.97)  LDD0545  [1]
 LDCM0229  AC112 HCT 116 C14(1.05); C32(0.84)  LDD0546  [1]
 LDCM0230  AC113 HCT 116 C14(0.74); C32(0.74)  LDD0547  [1]
 LDCM0231  AC114 HCT 116 C14(1.25); C32(0.87)  LDD0548  [1]
 LDCM0232  AC115 HCT 116 C14(1.15); C32(0.82)  LDD0549  [1]
 LDCM0233  AC116 HCT 116 C14(1.15); C32(1.00)  LDD0550  [1]
 LDCM0234  AC117 HCT 116 C14(0.96); C32(1.00)  LDD0551  [1]
 LDCM0235  AC118 HCT 116 C14(0.83); C32(0.98)  LDD0552  [1]
 LDCM0236  AC119 HCT 116 C14(1.51); C32(0.98)  LDD0553  [1]
 LDCM0238  AC120 HCT 116 C14(1.00); C32(0.96)  LDD0555  [1]
 LDCM0239  AC121 HCT 116 C14(0.92); C32(0.83)  LDD0556  [1]
 LDCM0240  AC122 HCT 116 C14(1.06); C32(0.92)  LDD0557  [1]
 LDCM0241  AC123 HCT 116 C14(1.33); C32(0.79)  LDD0558  [1]
 LDCM0242  AC124 HCT 116 C14(0.97); C32(0.98)  LDD0559  [1]
 LDCM0243  AC125 HCT 116 C14(1.15); C32(0.97)  LDD0560  [1]
 LDCM0244  AC126 HCT 116 C14(0.98); C32(0.96)  LDD0561  [1]
 LDCM0245  AC127 HCT 116 C14(0.97); C32(1.13)  LDD0562  [1]
 LDCM0263  AC143 HCT 116 C14(1.03); C32(1.03)  LDD0580  [1]
 LDCM0264  AC144 HCT 116 C32(1.01); C14(1.20)  LDD0581  [1]
 LDCM0265  AC145 HCT 116 C14(0.98); C32(1.00)  LDD0582  [1]
 LDCM0266  AC146 HCT 116 C32(0.98); C14(1.19)  LDD0583  [1]
 LDCM0267  AC147 HCT 116 C14(1.12); C32(1.21)  LDD0584  [1]
 LDCM0268  AC148 HCT 116 C32(1.18); C14(1.18)  LDD0585  [1]
 LDCM0269  AC149 HCT 116 C32(1.11); C14(1.13)  LDD0586  [1]
 LDCM0271  AC150 HCT 116 C32(0.95); C14(1.03)  LDD0588  [1]
 LDCM0272  AC151 HCT 116 C14(1.01); C32(1.03)  LDD0589  [1]
 LDCM0273  AC152 HCT 116 C14(1.16); C32(1.16)  LDD0590  [1]
 LDCM0274  AC153 HCT 116 C32(1.41); C14(1.49)  LDD0591  [1]
 LDCM0621  AC154 HCT 116 C14(1.10); C32(1.13)  LDD2158  [1]
 LDCM0622  AC155 HCT 116 C14(1.17); C32(1.15)  LDD2159  [1]
 LDCM0623  AC156 HCT 116 C14(1.18); C32(0.94)  LDD2160  [1]
 LDCM0624  AC157 HCT 116 C14(1.26); C32(1.15)  LDD2161  [1]
 LDCM0279  AC2 HCT 116 C14(1.11); C32(1.11)  LDD0596  [1]
 LDCM0285  AC25 HCT 116 C14(1.18); C32(1.18)  LDD0602  [1]
 LDCM0286  AC26 HCT 116 C14(1.04); C32(1.04)  LDD0603  [1]
 LDCM0287  AC27 HCT 116 C14(1.11); C32(1.11)  LDD0604  [1]
 LDCM0288  AC28 HCT 116 C14(1.07); C32(1.07)  LDD0605  [1]
 LDCM0289  AC29 HCT 116 C14(1.20); C32(1.20)  LDD0606  [1]
 LDCM0290  AC3 HCT 116 C14(0.95); C32(0.95)  LDD0607  [1]
 LDCM0291  AC30 HCT 116 C14(1.20); C32(1.20)  LDD0608  [1]
 LDCM0292  AC31 HCT 116 C14(0.93); C32(0.93)  LDD0609  [1]
 LDCM0293  AC32 HCT 116 C14(1.41); C32(1.41)  LDD0610  [1]
 LDCM0294  AC33 HCT 116 C14(1.63); C32(1.63)  LDD0611  [1]
 LDCM0295  AC34 HCT 116 C14(1.46); C32(1.46)  LDD0612  [1]
 LDCM0296  AC35 HCT 116 C14(0.87); C32(0.87)  LDD0613  [1]
 LDCM0297  AC36 HCT 116 C14(0.73); C32(0.73)  LDD0614  [1]
 LDCM0298  AC37 HCT 116 C14(0.82); C32(0.82)  LDD0615  [1]
 LDCM0299  AC38 HCT 116 C14(0.96); C32(0.96)  LDD0616  [1]
 LDCM0300  AC39 HCT 116 C14(1.18); C32(1.18)  LDD0617  [1]
 LDCM0301  AC4 HCT 116 C14(0.87); C32(0.87)  LDD0618  [1]
 LDCM0302  AC40 HCT 116 C14(1.09); C32(1.09)  LDD0619  [1]
 LDCM0303  AC41 HCT 116 C14(0.89); C32(0.89)  LDD0620  [1]
 LDCM0304  AC42 HCT 116 C14(1.02); C32(1.02)  LDD0621  [1]
 LDCM0305  AC43 HCT 116 C14(0.89); C32(0.89)  LDD0622  [1]
 LDCM0306  AC44 HCT 116 C14(0.98); C32(0.98)  LDD0623  [1]
 LDCM0307  AC45 HCT 116 C14(1.25); C32(1.25)  LDD0624  [1]
 LDCM0308  AC46 HCT 116 C14(0.73); C32(0.73)  LDD0625  [1]
 LDCM0309  AC47 HCT 116 C14(0.77); C32(0.77)  LDD0626  [1]
 LDCM0310  AC48 HCT 116 C14(0.71); C32(0.71)  LDD0627  [1]
 LDCM0311  AC49 HCT 116 C14(1.36); C32(1.36)  LDD0628  [1]
 LDCM0312  AC5 HCT 116 C14(0.98); C32(0.98)  LDD0629  [1]
 LDCM0313  AC50 HCT 116 C14(1.25); C32(1.25)  LDD0630  [1]
 LDCM0314  AC51 HCT 116 C14(0.71); C32(0.71)  LDD0631  [1]
 LDCM0315  AC52 HCT 116 C14(0.91); C32(0.91)  LDD0632  [1]
 LDCM0316  AC53 HCT 116 C14(1.26); C32(1.26)  LDD0633  [1]
 LDCM0317  AC54 HCT 116 C14(1.12); C32(1.12)  LDD0634  [1]
 LDCM0318  AC55 HCT 116 C14(1.29); C32(1.29)  LDD0635  [1]
 LDCM0319  AC56 HCT 116 C14(1.72); C32(1.72)  LDD0636  [1]
 LDCM0320  AC57 HCT 116 C14(1.55); C32(1.55)  LDD0637  [1]
 LDCM0321  AC58 HCT 116 C14(1.21); C32(1.21)  LDD0638  [1]
 LDCM0322  AC59 HCT 116 C14(1.68); C32(1.68)  LDD0639  [1]
 LDCM0324  AC60 HCT 116 C14(1.32); C32(1.32)  LDD0641  [1]
 LDCM0325  AC61 HCT 116 C14(0.98); C32(0.98)  LDD0642  [1]
 LDCM0326  AC62 HCT 116 C14(1.54); C32(1.54)  LDD0643  [1]
 LDCM0327  AC63 HCT 116 C14(1.53); C32(1.53)  LDD0644  [1]
 LDCM0328  AC64 HCT 116 C14(1.56); C32(1.56)  LDD0645  [1]
 LDCM0329  AC65 HCT 116 C14(1.17); C32(1.17)  LDD0646  [1]
 LDCM0330  AC66 HCT 116 C14(1.13); C32(1.13)  LDD0647  [1]
 LDCM0331  AC67 HCT 116 C14(1.21); C32(1.21)  LDD0648  [1]
 LDCM0332  AC68 HCT 116 C14(1.05); C32(1.05)  LDD0649  [1]
 LDCM0333  AC69 HCT 116 C14(0.96); C32(0.96)  LDD0650  [1]
 LDCM0335  AC70 HCT 116 C14(1.39); C32(1.39)  LDD0652  [1]
 LDCM0336  AC71 HCT 116 C14(0.97); C32(0.97)  LDD0653  [1]
 LDCM0337  AC72 HCT 116 C14(0.92); C32(0.92)  LDD0654  [1]
 LDCM0338  AC73 HCT 116 C14(1.22); C32(1.22)  LDD0655  [1]
 LDCM0339  AC74 HCT 116 C14(1.33); C32(1.33)  LDD0656  [1]
 LDCM0340  AC75 HCT 116 C14(1.71); C32(1.71)  LDD0657  [1]
 LDCM0341  AC76 HCT 116 C14(1.15); C32(1.15)  LDD0658  [1]
 LDCM0342  AC77 HCT 116 C14(1.24); C32(1.24)  LDD0659  [1]
 LDCM0343  AC78 HCT 116 C14(0.83); C32(0.83)  LDD0660  [1]
 LDCM0344  AC79 HCT 116 C14(0.98); C32(0.98)  LDD0661  [1]
 LDCM0346  AC80 HCT 116 C14(0.98); C32(0.98)  LDD0663  [1]
 LDCM0347  AC81 HCT 116 C14(0.89); C32(0.89)  LDD0664  [1]
 LDCM0348  AC82 HCT 116 C14(1.64); C32(1.64)  LDD0665  [1]
 LDCM0365  AC98 HCT 116 C14(1.38); C32(1.38)  LDD0682  [1]
 LDCM0366  AC99 HCT 116 C14(0.84); C32(0.84)  LDD0683  [1]
 LDCM0369  CL100 HCT 116 C14(1.00); C32(1.00)  LDD0686  [1]
 LDCM0382  CL112 HCT 116 C14(1.24); C32(1.24)  LDD0699  [1]
 LDCM0383  CL113 HCT 116 C14(1.07); C32(1.07)  LDD0700  [1]
 LDCM0384  CL114 HCT 116 C14(1.15); C32(1.15)  LDD0701  [1]
 LDCM0385  CL115 HCT 116 C14(1.10); C32(1.10)  LDD0702  [1]
 LDCM0386  CL116 HCT 116 C14(1.00); C32(1.00)  LDD0703  [1]
 LDCM0387  CL117 HCT 116 C14(1.60); C32(1.60)  LDD0704  [1]
 LDCM0388  CL118 HCT 116 C14(1.08); C32(1.08)  LDD0705  [1]
 LDCM0389  CL119 HCT 116 C14(1.18); C32(1.18)  LDD0706  [1]
 LDCM0391  CL120 HCT 116 C14(0.89); C32(0.89)  LDD0708  [1]
 LDCM0392  CL121 HCT 116 C14(3.21); C32(3.21)  LDD0709  [1]
 LDCM0393  CL122 HCT 116 C14(0.80); C32(0.80)  LDD0710  [1]
 LDCM0394  CL123 HCT 116 C14(1.08); C32(1.08)  LDD0711  [1]
 LDCM0395  CL124 HCT 116 C14(1.11); C32(1.11)  LDD0712  [1]
 LDCM0396  CL125 HCT 116 C14(0.96); C32(0.96)  LDD0713  [1]
 LDCM0397  CL126 HCT 116 C14(1.29); C32(1.29)  LDD0714  [1]
 LDCM0398  CL127 HCT 116 C14(1.44); C32(1.44)  LDD0715  [1]
 LDCM0399  CL128 HCT 116 C14(1.83); C32(1.83)  LDD0716  [1]
 LDCM0403  CL16 HCT 116 C14(1.36); C32(1.36)  LDD0720  [1]
 LDCM0404  CL17 HCT 116 C14(0.85); C32(0.85)  LDD0721  [1]
 LDCM0405  CL18 HCT 116 C14(1.04); C32(1.04)  LDD0722  [1]
 LDCM0406  CL19 HCT 116 C14(0.85); C32(0.85)  LDD0723  [1]
 LDCM0408  CL20 HCT 116 C14(0.76); C32(0.76)  LDD0725  [1]
 LDCM0409  CL21 HCT 116 C14(0.89); C32(0.89)  LDD0726  [1]
 LDCM0410  CL22 HCT 116 C14(0.79); C32(0.79)  LDD0727  [1]
 LDCM0411  CL23 HCT 116 C14(0.94); C32(0.94)  LDD0728  [1]
 LDCM0412  CL24 HCT 116 C14(1.44); C32(1.44)  LDD0729  [1]
 LDCM0413  CL25 HCT 116 C14(1.19); C32(1.19)  LDD0730  [1]
 LDCM0414  CL26 HCT 116 C14(1.07); C32(1.07)  LDD0731  [1]
 LDCM0415  CL27 HCT 116 C14(1.05); C32(1.05)  LDD0732  [1]
 LDCM0416  CL28 HCT 116 C14(0.97); C32(0.97)  LDD0733  [1]
 LDCM0417  CL29 HCT 116 C14(1.10); C32(1.10)  LDD0734  [1]
 LDCM0419  CL30 HCT 116 C14(1.04); C32(1.04)  LDD0736  [1]
 LDCM0436  CL46 HCT 116 C14(1.16); C32(1.16)  LDD0753  [1]
 LDCM0437  CL47 HCT 116 C14(0.96); C32(0.96)  LDD0754  [1]
 LDCM0438  CL48 HCT 116 C14(0.86); C32(0.86)  LDD0755  [1]
 LDCM0439  CL49 HCT 116 C14(0.92); C32(0.92)  LDD0756  [1]
 LDCM0441  CL50 HCT 116 C14(0.90); C32(0.90)  LDD0758  [1]
 LDCM0442  CL51 HCT 116 C14(0.90); C32(0.90)  LDD0759  [1]
 LDCM0443  CL52 HCT 116 C14(1.19); C32(1.19)  LDD0760  [1]
 LDCM0444  CL53 HCT 116 C14(1.04); C32(1.04)  LDD0761  [1]
 LDCM0445  CL54 HCT 116 C14(0.96); C32(0.96)  LDD0762  [1]
 LDCM0446  CL55 HCT 116 C14(0.93); C32(0.93)  LDD0763  [1]
 LDCM0447  CL56 HCT 116 C14(0.98); C32(0.98)  LDD0764  [1]
 LDCM0448  CL57 HCT 116 C14(0.83); C32(0.83)  LDD0765  [1]
 LDCM0449  CL58 HCT 116 C14(0.91); C32(0.91)  LDD0766  [1]
 LDCM0450  CL59 HCT 116 C14(0.96); C32(0.96)  LDD0767  [1]
 LDCM0452  CL60 HCT 116 C14(1.04); C32(1.04)  LDD0769  [1]
 LDCM0486  CL91 HCT 116 C14(0.94); C32(0.94)  LDD0803  [1]
 LDCM0487  CL92 HCT 116 C14(1.04); C32(1.04)  LDD0804  [1]
 LDCM0488  CL93 HCT 116 C14(0.87); C32(0.87)  LDD0805  [1]
 LDCM0489  CL94 HCT 116 C14(1.03); C32(1.03)  LDD0806  [1]
 LDCM0490  CL95 HCT 116 C14(1.26); C32(1.26)  LDD0807  [1]
 LDCM0491  CL96 HCT 116 C14(1.03); C32(1.03)  LDD0808  [1]
 LDCM0492  CL97 HCT 116 C14(1.06); C32(1.06)  LDD0809  [1]
 LDCM0493  CL98 HCT 116 C14(1.01); C32(1.01)  LDD0810  [1]
 LDCM0494  CL99 HCT 116 C14(1.01); C32(1.01)  LDD0811  [1]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
NADH dehydrogenase flavoprotein 2, mitochondrial (NDUFV2) Complex I 24 kDa subunit family P19404
Transporter and channel
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Amyloid-beta precursor protein (APP) APP family P05067
Other
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Synaptogyrin-2 (SYNGR2) Synaptogyrin family O43760

References

1 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
2 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
3 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587