Details of the Target

General Information of Target

Target ID LDTP07289
Target Name WASH complex subunit 2A (WASHC2A)
Gene Name WASHC2A
Gene ID 387680
Synonyms
FAM21A; FAM21B; WASH complex subunit 2A
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MMNRTTPDQELAPASEPVWERPWSVEEIRRSSQSWSLAADAGLLQFLQEFSQQTISRTHE
IKKQVDGLIRETKATDCRLHNVFNDFLMLSNTQFIENRVYDEEVEEPVLKAEAEKTEQEK
TREQKEVDLIPKVQEAVNYGLQVLDSAFEQLDIKAGNSDSEEDDANGRVELILEPKDLYI
DRPLPYLIGSKLFMEQEDVGLGELSSEEGSVGSDRGSIVDTEEEKEEEESDEDFAHHSDN
EQNRHTTQMSDEEEDDDGCDLFADSEKEEEDIEDIEENTRPKRSRPTSFADELAARIKGD
AVGRVDEEPTTLPSGEAKPRKTLKEKKERRTPSDDEEDNLFAPPKLTDEDFSPFGSGGGL
FSGGKGLFDDEDEESDLFTEAPQDRQAGASVKEESSSSKPGKKIPAGAVSVFLGDTDVFG
AASVPSMKEPQKPEQPTPRKSPYGPPPTGLFDDDDGDDDDDFFSAPHSKPSKTGKVQSTA
DIFGDEEGDLFKEKAVASPEATVSQTDENKARAEKKVTLSSSKNLKPSSETKTQKGLFSD
EEDSEDLFSSQSASKLKGASLLPGKLPTLVSLFDDEDEEDNLFGGTAAKKQTLCLQAQRE
EKAKASELSKKKASALLFSSDEEDQWNIPASQTHLASDSRSKGEPRDSGTLQSQEAKAVK
KTSLFEEDEEDDLFAIAKDSQKKTQRVSLLFEDDVDSGGSLFGSPPTSVPPATKKKETVS
EAPPLLFSDEEEKEAQLGVKSVDKKVESAKESLKFGRTDVAESEKEGLLTRSAQETVKHS
DLFSSSSPWDKGTKPRTKTVLSLFDEEEDKMEDQNIIQAPQKEVGKGRDPDAHPKSTGVF
QDEELLFSHKLQKDNDPDVDLFAGTKKTKLLEPSVGSLFGDDEDDDLFSSAKSQPLVQEK
KRVVKKDHSVDSFKNQKHPESIQGSKEKGIWKPETPQDSSGLAPFKTKEPSTRIGKIQAN
LAINPAALLPTAASQISEVKPVLPELAFPSSEHRRSHGLESVPVLPGSGEAGVSFDLPAQ
ADTLHSANKSRVKMRGKRRPQTRAARRLAAQESSETEDMSVPRGPIAQWADGAISPNGHR
PQLRAASGEDSTEEALAAAAAPWEGGPVPGVDRSPFAKSLGHSRGEADLFDSGDIFSTGT
GSQSVERTKPKAKIAENPANPPVGGKAKSPMFPALGEASSDDDLFQSAKPKPAKKTNPFP
LLEDEDDLFTDQKVKKNETKSNSQQDVILTTQDIFEDDIFATEAIKPSQKTREKEKTLES
NLFDDNIDIFADLTVKPKEKSKKKVEAKSIFDDDMDDIFSSGIQAKTTKPKSRSAQAAPE
PRFEHKVSNIFDDPLNAFGGQ
Target Bioclass
Transporter and channel
Family
FAM21 family
Subcellular location
Early endosome membrane
Function
Acts at least in part as component of the WASH core complex whose assembly at the surface of endosomes inhibits WASH nucleation-promoting factor (NPF) activity in recruiting and activating the Arp2/3 complex to induce actin polymerization and is involved in the fission of tubules that serve as transport intermediates during endosome sorting. Mediates the recruitment of the WASH core complex to endosome membranes via binding to phospholipids and VPS35 of the retromer CSC. Mediates the recruitment of the F-actin-capping protein dimer to the WASH core complex probably promoting localized F-actin polymerization needed for vesicle scission. Via its C-terminus binds various phospholipids, most strongly phosphatidylinositol 4-phosphate (PtdIns-(4)P), phosphatidylinositol 5-phosphate (PtdIns-(5)P) and phosphatidylinositol 3,5-bisphosphate (PtdIns-(3,5)P2). Involved in the endosome-to-plasma membrane trafficking and recycling of SNX27-retromer-dependent cargo proteins, such as GLUT1. Required for the association of DNAJC13, ENTR1, ANKRD50 with retromer CSC subunit VPS35. Required for the endosomal recruitment of CCC complex subunits COMMD1 and CCDC93 as well as the retriever complex subunit VPS35L.
Uniprot ID
Q641Q2
Ensemble ID
ENST00000282633.10
HGNC ID
HGNC:23416

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 10 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		15.00  LDD0402  [1]
DBIA
 Probe Info  		C594(1.13)  LDD0078  [2]
5E-2FA
 Probe Info  		N.A.  LDD2235  [3]
IA-alkyne
 Probe Info  		N.A.  LDD0165  [4]
BTD
 Probe Info  		N.A.  LDD0004  [5]
NAIA_5
 Probe Info  		N.A.  LDD2224  [6]
WYneN
 Probe Info  		N.A.  LDD0021  [5]
IPM
 Probe Info  		N.A.  LDD0005  [5]
Phosphinate-6
 Probe Info  		N.A.  LDD0018  [7]
AOyne
 Probe Info  		13.00  LDD0443  [8]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HCT 116 C594(0.95)  LDD0531  [2]
 LDCM0215  AC10 PaTu 8988t C594(1.87)  LDD1094  [2]
 LDCM0216  AC100 HCT 116 C594(1.07)  LDD0533  [2]
 LDCM0217  AC101 HCT 116 C594(1.04)  LDD0534  [2]
 LDCM0218  AC102 HCT 116 C594(1.02)  LDD0535  [2]
 LDCM0219  AC103 HCT 116 C594(1.19)  LDD0536  [2]
 LDCM0220  AC104 HCT 116 C594(1.23)  LDD0537  [2]
 LDCM0221  AC105 HCT 116 C594(1.19)  LDD0538  [2]
 LDCM0222  AC106 HCT 116 C594(1.40)  LDD0539  [2]
 LDCM0223  AC107 HCT 116 C594(1.45)  LDD0540  [2]
 LDCM0224  AC108 HCT 116 C594(1.22)  LDD0541  [2]
 LDCM0225  AC109 HCT 116 C594(0.96)  LDD0542  [2]
 LDCM0226  AC11 PaTu 8988t C594(1.34)  LDD1105  [2]
 LDCM0227  AC110 HCT 116 C594(0.86)  LDD0544  [2]
 LDCM0228  AC111 HCT 116 C594(0.94)  LDD0545  [2]
 LDCM0229  AC112 HCT 116 C594(1.06)  LDD0546  [2]
 LDCM0230  AC113 HEK-293T C594(0.98)  LDD0828  [2]
 LDCM0231  AC114 HEK-293T C594(0.79)  LDD0829  [2]
 LDCM0232  AC115 HEK-293T C594(0.95)  LDD0830  [2]
 LDCM0233  AC116 HEK-293T C594(0.84)  LDD0831  [2]
 LDCM0234  AC117 HEK-293T C594(0.95)  LDD0832  [2]
 LDCM0235  AC118 HEK-293T C594(0.84)  LDD0833  [2]
 LDCM0236  AC119 HEK-293T C594(0.91)  LDD0834  [2]
 LDCM0237  AC12 PaTu 8988t C594(1.84)  LDD1116  [2]
 LDCM0238  AC120 HEK-293T C594(1.08)  LDD0836  [2]
 LDCM0239  AC121 HEK-293T C594(1.03)  LDD0837  [2]
 LDCM0240  AC122 HEK-293T C594(0.92)  LDD0838  [2]
 LDCM0241  AC123 HEK-293T C594(0.79)  LDD0839  [2]
 LDCM0242  AC124 HEK-293T C594(1.01)  LDD0840  [2]
 LDCM0243  AC125 HEK-293T C594(0.98)  LDD0841  [2]
 LDCM0244  AC126 HEK-293T C594(1.26)  LDD0842  [2]
 LDCM0245  AC127 HEK-293T C594(1.03)  LDD0843  [2]
 LDCM0246  AC128 PaTu 8988t C594(1.32)  LDD1125  [2]
 LDCM0247  AC129 PaTu 8988t C594(1.38)  LDD1126  [2]
 LDCM0249  AC130 PaTu 8988t C594(1.07)  LDD1128  [2]
 LDCM0250  AC131 PaTu 8988t C594(0.92)  LDD1129  [2]
 LDCM0251  AC132 PaTu 8988t C594(1.17)  LDD1130  [2]
 LDCM0252  AC133 PaTu 8988t C594(1.06)  LDD1131  [2]
 LDCM0253  AC134 PaTu 8988t C594(1.10)  LDD1132  [2]
 LDCM0254  AC135 PaTu 8988t C594(1.18)  LDD1133  [2]
 LDCM0255  AC136 PaTu 8988t C594(1.21)  LDD1134  [2]
 LDCM0256  AC137 PaTu 8988t C594(1.15)  LDD1135  [2]
 LDCM0257  AC138 PaTu 8988t C594(1.38)  LDD1136  [2]
 LDCM0258  AC139 PaTu 8988t C594(1.02)  LDD1137  [2]
 LDCM0259  AC14 PaTu 8988t C594(1.36)  LDD1138  [2]
 LDCM0260  AC140 PaTu 8988t C594(1.40)  LDD1139  [2]
 LDCM0261  AC141 PaTu 8988t C594(1.28)  LDD1140  [2]
 LDCM0262  AC142 PaTu 8988t C594(1.26)  LDD1141  [2]
 LDCM0263  AC143 HCT 116 C594(1.46)  LDD0580  [2]
 LDCM0264  AC144 HCT 116 C594(0.94)  LDD0581  [2]
 LDCM0265  AC145 HCT 116 C594(1.00)  LDD0582  [2]
 LDCM0266  AC146 HCT 116 C594(1.29)  LDD0583  [2]
 LDCM0267  AC147 HCT 116 C594(1.17)  LDD0584  [2]
 LDCM0268  AC148 HCT 116 C594(1.73)  LDD0585  [2]
 LDCM0269  AC149 HCT 116 C594(1.48)  LDD0586  [2]
 LDCM0270  AC15 PaTu 8988t C594(1.43)  LDD1149  [2]
 LDCM0271  AC150 HCT 116 C594(1.30)  LDD0588  [2]
 LDCM0272  AC151 HCT 116 C594(1.11)  LDD0589  [2]
 LDCM0273  AC152 HCT 116 C594(1.42)  LDD0590  [2]
 LDCM0274  AC153 HCT 116 C594(1.83)  LDD0591  [2]
 LDCM0621  AC154 HCT 116 C594(1.41)  LDD2158  [2]
 LDCM0622  AC155 HCT 116 C594(0.86)  LDD2159  [2]
 LDCM0623  AC156 HCT 116 C594(1.10)  LDD2160  [2]
 LDCM0624  AC157 HCT 116 C594(0.93)  LDD2161  [2]
 LDCM0276  AC17 HCT 116 C594(0.94)  LDD0593  [2]
 LDCM0277  AC18 HCT 116 C594(0.86)  LDD0594  [2]
 LDCM0278  AC19 HCT 116 C594(0.92)  LDD0595  [2]
 LDCM0279  AC2 HCT 116 C594(0.79)  LDD0596  [2]
 LDCM0280  AC20 HCT 116 C594(1.09)  LDD0597  [2]
 LDCM0281  AC21 HCT 116 C594(0.84)  LDD0598  [2]
 LDCM0282  AC22 HCT 116 C594(0.85)  LDD0599  [2]
 LDCM0283  AC23 HCT 116 C594(1.01)  LDD0600  [2]
 LDCM0284  AC24 HCT 116 C594(1.08)  LDD0601  [2]
 LDCM0285  AC25 PaTu 8988t C594(0.93)  LDD1164  [2]
 LDCM0286  AC26 PaTu 8988t C594(1.08)  LDD1165  [2]
 LDCM0287  AC27 PaTu 8988t C594(1.17)  LDD1166  [2]
 LDCM0288  AC28 PaTu 8988t C594(1.16)  LDD1167  [2]
 LDCM0289  AC29 PaTu 8988t C594(1.13)  LDD1168  [2]
 LDCM0290  AC3 HCT 116 C594(0.88)  LDD0607  [2]
 LDCM0291  AC30 PaTu 8988t C594(1.05)  LDD1170  [2]
 LDCM0292  AC31 PaTu 8988t C594(0.97)  LDD1171  [2]
 LDCM0293  AC32 PaTu 8988t C594(1.05)  LDD1172  [2]
 LDCM0294  AC33 PaTu 8988t C594(1.06)  LDD1173  [2]
 LDCM0295  AC34 PaTu 8988t C594(1.33)  LDD1174  [2]
 LDCM0296  AC35 PaTu 8988t C594(1.25)  LDD1175  [2]
 LDCM0297  AC36 PaTu 8988t C594(1.74)  LDD1176  [2]
 LDCM0298  AC37 PaTu 8988t C594(2.24)  LDD1177  [2]
 LDCM0299  AC38 PaTu 8988t C594(2.38)  LDD1178  [2]
 LDCM0300  AC39 PaTu 8988t C594(3.26)  LDD1179  [2]
 LDCM0301  AC4 HCT 116 C594(1.08)  LDD0618  [2]
 LDCM0302  AC40 PaTu 8988t C594(2.54)  LDD1181  [2]
 LDCM0303  AC41 PaTu 8988t C594(1.84)  LDD1182  [2]
 LDCM0304  AC42 PaTu 8988t C594(2.13)  LDD1183  [2]
 LDCM0305  AC43 PaTu 8988t C594(1.94)  LDD1184  [2]
 LDCM0306  AC44 PaTu 8988t C594(3.19)  LDD1185  [2]
 LDCM0307  AC45 PaTu 8988t C594(2.64)  LDD1186  [2]
 LDCM0308  AC46 HCT 116 C594(1.09)  LDD0625  [2]
 LDCM0309  AC47 HCT 116 C594(0.96)  LDD0626  [2]
 LDCM0310  AC48 HCT 116 C594(1.02)  LDD0627  [2]
 LDCM0311  AC49 HCT 116 C594(1.11)  LDD0628  [2]
 LDCM0312  AC5 HCT 116 C594(0.86)  LDD0629  [2]
 LDCM0313  AC50 HCT 116 C594(0.93)  LDD0630  [2]
 LDCM0314  AC51 HCT 116 C594(0.91)  LDD0631  [2]
 LDCM0315  AC52 HCT 116 C594(0.87)  LDD0632  [2]
 LDCM0316  AC53 HCT 116 C594(0.82)  LDD0633  [2]
 LDCM0317  AC54 HCT 116 C594(0.81)  LDD0634  [2]
 LDCM0318  AC55 HCT 116 C594(0.92)  LDD0635  [2]
 LDCM0319  AC56 HCT 116 C594(0.93)  LDD0636  [2]
 LDCM0320  AC57 HCT 116 C594(1.48)  LDD0637  [2]
 LDCM0321  AC58 HCT 116 C594(1.28)  LDD0638  [2]
 LDCM0322  AC59 HCT 116 C594(1.17)  LDD0639  [2]
 LDCM0323  AC6 PaTu 8988t C594(1.07)  LDD1202  [2]
 LDCM0324  AC60 HCT 116 C594(1.53)  LDD0641  [2]
 LDCM0325  AC61 HCT 116 C594(1.30)  LDD0642  [2]
 LDCM0326  AC62 HCT 116 C594(1.55)  LDD0643  [2]
 LDCM0327  AC63 HCT 116 C594(1.35)  LDD0644  [2]
 LDCM0328  AC64 HCT 116 C594(1.94)  LDD0645  [2]
 LDCM0329  AC65 HCT 116 C594(1.15)  LDD0646  [2]
 LDCM0330  AC66 HCT 116 C594(1.08)  LDD0647  [2]
 LDCM0331  AC67 HCT 116 C594(1.27)  LDD0648  [2]
 LDCM0334  AC7 PaTu 8988t C594(0.67)  LDD1213  [2]
 LDCM0345  AC8 PaTu 8988t C594(1.17)  LDD1224  [2]
 LDCM0349  AC83 HEK-293T C594(1.04)  LDD0947  [2]
 LDCM0350  AC84 HEK-293T C594(1.48)  LDD0948  [2]
 LDCM0351  AC85 HEK-293T C594(1.23)  LDD0949  [2]
 LDCM0352  AC86 HEK-293T C594(1.26)  LDD0950  [2]
 LDCM0353  AC87 HEK-293T C594(1.33)  LDD0951  [2]
 LDCM0354  AC88 HEK-293T C594(1.32)  LDD0952  [2]
 LDCM0355  AC89 HEK-293T C594(1.86)  LDD0953  [2]
 LDCM0357  AC90 HEK-293T C594(1.18)  LDD0955  [2]
 LDCM0358  AC91 HEK-293T C594(0.91)  LDD0956  [2]
 LDCM0359  AC92 HEK-293T C594(0.96)  LDD0957  [2]
 LDCM0360  AC93 HEK-293T C594(1.22)  LDD0958  [2]
 LDCM0361  AC94 HEK-293T C594(1.49)  LDD0959  [2]
 LDCM0362  AC95 HEK-293T C594(1.42)  LDD0960  [2]
 LDCM0363  AC96 HEK-293T C594(0.93)  LDD0961  [2]
 LDCM0364  AC97 HEK-293T C594(1.15)  LDD0962  [2]
 LDCM0365  AC98 HCT 116 C594(1.49)  LDD0682  [2]
 LDCM0366  AC99 HCT 116 C594(1.04)  LDD0683  [2]
 LDCM0248  AKOS034007472 PaTu 8988t C594(1.36)  LDD1127  [2]
 LDCM0356  AKOS034007680 PaTu 8988t C594(1.34)  LDD1235  [2]
 LDCM0275  AKOS034007705 PaTu 8988t C594(1.42)  LDD1154  [2]
 LDCM0156  Aniline NCI-H1299 15.00  LDD0403  [1]
 LDCM0020  ARS-1620 HCC44 C594(1.13)  LDD0078  [2]
 LDCM0632  CL-Sc Hep-G2 C594(20.00)  LDD2227  [6]
 LDCM0367  CL1 HEK-293T C594(0.89)  LDD1571  [9]
 LDCM0368  CL10 HEK-293T C594(0.86)  LDD1572  [9]
 LDCM0369  CL100 HCT 116 C594(1.13)  LDD0686  [2]
 LDCM0370  CL101 PaTu 8988t C594(0.95)  LDD1249  [2]
 LDCM0371  CL102 PaTu 8988t C594(1.19)  LDD1250  [2]
 LDCM0372  CL103 PaTu 8988t C594(2.03)  LDD1251  [2]
 LDCM0373  CL104 PaTu 8988t C594(1.05)  LDD1252  [2]
 LDCM0374  CL105 HCT 116 C594(1.12)  LDD0691  [2]
 LDCM0375  CL106 HCT 116 C594(1.09)  LDD0692  [2]
 LDCM0376  CL107 HCT 116 C594(0.98)  LDD0693  [2]
 LDCM0377  CL108 HCT 116 C594(0.60)  LDD0694  [2]
 LDCM0378  CL109 HCT 116 C594(0.62)  LDD0695  [2]
 LDCM0379  CL11 HEK-293T C594(1.05)  LDD1583  [9]
 LDCM0380  CL110 HCT 116 C594(0.95)  LDD0697  [2]
 LDCM0381  CL111 HCT 116 C594(0.93)  LDD0698  [2]
 LDCM0382  CL112 PaTu 8988t C594(1.21)  LDD1261  [2]
 LDCM0383  CL113 PaTu 8988t C594(1.04)  LDD1262  [2]
 LDCM0384  CL114 PaTu 8988t C594(1.08)  LDD1263  [2]
 LDCM0385  CL115 PaTu 8988t C594(1.17)  LDD1264  [2]
 LDCM0386  CL116 PaTu 8988t C594(0.94)  LDD1265  [2]
 LDCM0387  CL117 PaTu 8988t C594(1.94)  LDD1266  [2]
 LDCM0388  CL118 PaTu 8988t C594(1.92)  LDD1267  [2]
 LDCM0389  CL119 PaTu 8988t C594(3.02)  LDD1268  [2]
 LDCM0390  CL12 HEK-293T C594(0.83)  LDD1594  [9]
 LDCM0391  CL120 PaTu 8988t C594(1.91)  LDD1270  [2]
 LDCM0392  CL121 HCT 116 C594(0.93)  LDD0709  [2]
 LDCM0393  CL122 HCT 116 C594(0.92)  LDD0710  [2]
 LDCM0394  CL123 HCT 116 C594(0.75)  LDD0711  [2]
 LDCM0395  CL124 HCT 116 C594(0.77)  LDD0712  [2]
 LDCM0396  CL125 HCT 116 C594(1.18)  LDD0713  [2]
 LDCM0397  CL126 HCT 116 C594(0.81)  LDD0714  [2]
 LDCM0398  CL127 HCT 116 C594(0.99)  LDD0715  [2]
 LDCM0399  CL128 HCT 116 C594(1.13)  LDD0716  [2]
 LDCM0400  CL13 HEK-293T C594(1.05)  LDD1604  [9]
 LDCM0401  CL14 HEK-293T C594(0.97)  LDD1605  [9]
 LDCM0402  CL15 HEK-293T C594(0.81)  LDD1606  [9]
 LDCM0403  CL16 PaTu 8988t C594(1.33)  LDD1282  [2]
 LDCM0404  CL17 PaTu 8988t C594(1.49)  LDD1283  [2]
 LDCM0405  CL18 PaTu 8988t C594(1.11)  LDD1284  [2]
 LDCM0406  CL19 PaTu 8988t C594(1.19)  LDD1285  [2]
 LDCM0407  CL2 HEK-293T C594(0.99)  LDD1611  [9]
 LDCM0408  CL20 PaTu 8988t C594(1.97)  LDD1287  [2]
 LDCM0409  CL21 PaTu 8988t C594(1.93)  LDD1288  [2]
 LDCM0410  CL22 PaTu 8988t C594(1.81)  LDD1289  [2]
 LDCM0411  CL23 PaTu 8988t C594(1.27)  LDD1290  [2]
 LDCM0412  CL24 PaTu 8988t C594(1.01)  LDD1291  [2]
 LDCM0413  CL25 PaTu 8988t C594(1.29)  LDD1292  [2]
 LDCM0414  CL26 PaTu 8988t C594(1.65)  LDD1293  [2]
 LDCM0415  CL27 PaTu 8988t C594(0.96)  LDD1294  [2]
 LDCM0416  CL28 PaTu 8988t C594(1.98)  LDD1295  [2]
 LDCM0417  CL29 PaTu 8988t C594(2.02)  LDD1296  [2]
 LDCM0418  CL3 HEK-293T C594(0.88)  LDD1622  [9]
 LDCM0419  CL30 PaTu 8988t C594(1.51)  LDD1298  [2]
 LDCM0420  CL31 HEK-293T C594(1.06)  LDD1624  [9]
 LDCM0421  CL32 HEK-293T C594(1.05)  LDD1625  [9]
 LDCM0422  CL33 HEK-293T C594(0.70)  LDD1626  [9]
 LDCM0423  CL34 HEK-293T C594(0.90)  LDD1627  [9]
 LDCM0424  CL35 HEK-293T C594(1.14)  LDD1628  [9]
 LDCM0425  CL36 HEK-293T C594(0.80)  LDD1629  [9]
 LDCM0426  CL37 HEK-293T C594(0.98)  LDD1630  [9]
 LDCM0428  CL39 HEK-293T C594(0.95)  LDD1632  [9]
 LDCM0429  CL4 HEK-293T C594(0.94)  LDD1633  [9]
 LDCM0430  CL40 HEK-293T C594(1.05)  LDD1634  [9]
 LDCM0431  CL41 HEK-293T C594(1.01)  LDD1635  [9]
 LDCM0432  CL42 HEK-293T C594(1.04)  LDD1636  [9]
 LDCM0433  CL43 HEK-293T C594(0.93)  LDD1637  [9]
 LDCM0434  CL44 HEK-293T C594(1.07)  LDD1638  [9]
 LDCM0435  CL45 HEK-293T C594(0.93)  LDD1639  [9]
 LDCM0436  CL46 PaTu 8988t C594(1.24)  LDD1315  [2]
 LDCM0437  CL47 PaTu 8988t C594(1.50)  LDD1316  [2]
 LDCM0438  CL48 PaTu 8988t C594(1.74)  LDD1317  [2]
 LDCM0439  CL49 PaTu 8988t C594(1.48)  LDD1318  [2]
 LDCM0440  CL5 HEK-293T C594(0.98)  LDD1644  [9]
 LDCM0441  CL50 PaTu 8988t C594(1.28)  LDD1320  [2]
 LDCM0442  CL51 PaTu 8988t C594(1.52)  LDD1321  [2]
 LDCM0443  CL52 PaTu 8988t C594(1.40)  LDD1322  [2]
 LDCM0444  CL53 PaTu 8988t C594(1.51)  LDD1323  [2]
 LDCM0445  CL54 PaTu 8988t C594(1.61)  LDD1324  [2]
 LDCM0446  CL55 PaTu 8988t C594(1.38)  LDD1325  [2]
 LDCM0447  CL56 PaTu 8988t C594(0.45)  LDD1326  [2]
 LDCM0448  CL57 PaTu 8988t C594(3.99)  LDD1327  [2]
 LDCM0449  CL58 PaTu 8988t C594(2.03)  LDD1328  [2]
 LDCM0450  CL59 PaTu 8988t C594(3.60)  LDD1329  [2]
 LDCM0451  CL6 HEK-293T C594(0.91)  LDD1654  [9]
 LDCM0452  CL60 PaTu 8988t C594(2.61)  LDD1331  [2]
 LDCM0453  CL61 PaTu 8988t C594(1.40)  LDD1332  [2]
 LDCM0454  CL62 PaTu 8988t C594(1.43)  LDD1333  [2]
 LDCM0455  CL63 PaTu 8988t C594(1.25)  LDD1334  [2]
 LDCM0456  CL64 PaTu 8988t C594(1.34)  LDD1335  [2]
 LDCM0457  CL65 PaTu 8988t C594(1.76)  LDD1336  [2]
 LDCM0458  CL66 PaTu 8988t C594(1.30)  LDD1337  [2]
 LDCM0459  CL67 PaTu 8988t C594(1.43)  LDD1338  [2]
 LDCM0460  CL68 PaTu 8988t C594(2.26)  LDD1339  [2]
 LDCM0461  CL69 PaTu 8988t C594(1.62)  LDD1340  [2]
 LDCM0462  CL7 HEK-293T C594(0.98)  LDD1665  [9]
 LDCM0463  CL70 PaTu 8988t C594(2.42)  LDD1342  [2]
 LDCM0464  CL71 PaTu 8988t C594(1.33)  LDD1343  [2]
 LDCM0465  CL72 PaTu 8988t C594(0.82)  LDD1344  [2]
 LDCM0466  CL73 PaTu 8988t C594(1.41)  LDD1345  [2]
 LDCM0467  CL74 PaTu 8988t C594(2.00)  LDD1346  [2]
 LDCM0469  CL76 HEK-293T C594(1.03)  LDD1672  [9]
 LDCM0470  CL77 HEK-293T C594(1.09)  LDD1673  [9]
 LDCM0471  CL78 HEK-293T C594(0.96)  LDD1674  [9]
 LDCM0472  CL79 HEK-293T C594(0.95)  LDD1675  [9]
 LDCM0473  CL8 HEK-293T C594(0.91)  LDD1676  [9]
 LDCM0474  CL80 HEK-293T C594(1.01)  LDD1677  [9]
 LDCM0475  CL81 HEK-293T C594(0.82)  LDD1678  [9]
 LDCM0476  CL82 HEK-293T C594(0.95)  LDD1679  [9]
 LDCM0477  CL83 HEK-293T C594(1.01)  LDD1680  [9]
 LDCM0478  CL84 HEK-293T C594(0.83)  LDD1681  [9]
 LDCM0479  CL85 HEK-293T C594(1.05)  LDD1682  [9]
 LDCM0480  CL86 HEK-293T C594(1.08)  LDD1683  [9]
 LDCM0481  CL87 HEK-293T C594(1.05)  LDD1684  [9]
 LDCM0482  CL88 HEK-293T C594(1.03)  LDD1685  [9]
 LDCM0483  CL89 HEK-293T C594(1.00)  LDD1686  [9]
 LDCM0484  CL9 HEK-293T C594(0.79)  LDD1687  [9]
 LDCM0485  CL90 HEK-293T C594(0.89)  LDD1688  [9]
 LDCM0486  CL91 HCT 116 C594(0.92)  LDD0803  [2]
 LDCM0487  CL92 HCT 116 C594(0.80)  LDD0804  [2]
 LDCM0488  CL93 HCT 116 C594(1.04)  LDD0805  [2]
 LDCM0489  CL94 HCT 116 C594(1.02)  LDD0806  [2]
 LDCM0490  CL95 HCT 116 C594(0.88)  LDD0807  [2]
 LDCM0491  CL96 HCT 116 C594(0.95)  LDD0808  [2]
 LDCM0492  CL97 HCT 116 C594(1.05)  LDD0809  [2]
 LDCM0493  CL98 HCT 116 C594(0.96)  LDD0810  [2]
 LDCM0494  CL99 HCT 116 C594(1.02)  LDD0811  [2]
 LDCM0495  E2913 HEK-293T C594(1.02)  LDD1698  [9]
 LDCM0625  F8 Ramos C594(1.51)  LDD2187  [10]
 LDCM0576  Fragment14 Ramos C594(0.64)  LDD2193  [10]
 LDCM0468  Fragment33 PaTu 8988t C594(1.64)  LDD1347  [2]
 LDCM0566  Fragment4 Ramos C594(0.83)  LDD2184  [10]
 LDCM0427  Fragment51 HEK-293T C594(1.00)  LDD1631  [9]
 LDCM0569  Fragment7 Ramos C594(1.28)  LDD2186  [10]
 LDCM0022  KB02 HEK-293T C594(0.82)  LDD1492  [9]
 LDCM0023  KB03 HEK-293T C594(1.01)  LDD1497  [9]
 LDCM0024  KB05 COLO792 C594(1.60)  LDD3310  [11]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Transporter and channel
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Coiled-coil domain-containing protein 22 (CCDC22) CCDC22 family O60826
Coiled-coil domain-containing protein 93 (CCDC93) CCDC93 family Q567U6

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
3 Global profiling of functional histidines in live cells using small-molecule photosensitizer and chemical probe relay labelling. Nat Chem. 2024 Jun 4. doi: 10.1038/s41557-024-01545-6. Online ahead of print.
Mass spectrometry data entry: PXD042377
4 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
5 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
6 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
7 DFT-Guided Discovery of Ethynyl-Triazolyl-Phosphinates as Modular Electrophiles for Chemoselective Cysteine Bioconjugation and Profiling. Angew Chem Int Ed Engl. 2022 Oct 10;61(41):e202205348. doi: 10.1002/anie.202205348. Epub 2022 Aug 22.
Mass spectrometry data entry: PXD033004
8 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
9 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
10 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578
11 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840