Details of the Target

General Information of Target

Target ID LDTP07158
Target Name Integrator complex subunit 11 (INTS11)
Gene Name INTS11
Gene ID 54973
Synonyms
CPSF3L; RC68; Integrator complex subunit 11; Int11; EC 3.1.27.-; Cleavage and polyadenylation-specific factor 3-like protein; CPSF3-like protein; Protein related to CPSF subunits of 68 kDa; RC-68
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MPEIRVTPLGAGQDVGRSCILVSIAGKNVMLDCGMHMGFNDDRRFPDFSYITQNGRLTDF
LDCVIISHFHLDHCGALPYFSEMVGYDGPIYMTHPTQAICPILLEDYRKIAVDKKGEANF
FTSQMIKDCMKKVVAVHLHQTVQVDDELEIKAYYAGHVLGAAMFQIKVGSESVVYTGDYN
MTPDRHLGAAWIDKCRPNLLITESTYATTIRDSKRCRERDFLKKVHETVERGGKVLIPVF
ALGRAQELCILLETFWERMNLKVPIYFSTGLTEKANHYYKLFIPWTNQKIRKTFVQRNMF
EFKHIKAFDRAFADNPGPMVVFATPGMLHAGQSLQIFRKWAGNEKNMVIMPGYCVQGTVG
HKILSGQRKLEMEGRQVLEVKMQVEYMSFSAHADAKGIMQLVGQAEPESVLLVHGEAKKM
EFLKQKIEQELRVNCYMPANGETVTLPTSPSIPVGISLGLLKREMAQGLLPEAKKPRLLH
GTLIMKDSNFRLVSSEQALKELGLAEHQLRFTCRVHLHDTRKEQETALRVYSHLKSVLKD
HCVQHLPDGSVTVESVLLQAAAPSEDPGTKVLLVSWTYQDEELGSFLTSLLKKGLPQAPS
Target Bioclass
Enzyme
Family
Metallo-beta-lactamase superfamily, RNA-metabolizing metallo-beta-lactamase-like family, INTS11 subfamily
Subcellular location
Nucleus
Function
Catalytic component of the Integrator (INT) complex, a complex involved in the small nuclear RNAs (snRNA) U1 and U2 transcription and in their 3'-box-dependent processing. The Integrator complex is associated with the C-terminal domain (CTD) of RNA polymerase II largest subunit (POLR2A) and is recruited to the U1 and U2 snRNAs genes. Mediates the snRNAs 3' cleavage. Mediates recruitment of cytoplasmic dynein to the nuclear envelope, probably as component of the INT complex.
Uniprot ID
Q5TA45
Ensemble ID
ENST00000419704.5
HGNC ID
HGNC:26052

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
HCT15 SNV: p.P447A .
Ishikawa (Heraklio) 02 ER SNV: p.H94R DBIA    Probe Info 
JURKAT SNV: p.S365N .
LNCaP clone FGC SNV: p.E385D DBIA    Probe Info 
MEWO SNV: p.F511C; p.T512P DBIA    Probe Info 
MOLT4 SNV: p.R185Q; p.Q356Ter IA-alkyne    Probe Info 
RKO SNV: p.V263A; p.V359I .
SNU245 SNV: p.M92V .
SW756 SNV: p.Q288H .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 11 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
STPyne
 Probe Info  		K114(10.00)  LDD0277  [1]
m-APA
 Probe Info  		12.41  LDD0403  [2]
DBIA
 Probe Info  		C94(1.55)  LDD3329  [3]
AHL-Pu-1
 Probe Info  		C542(2.56)  LDD0171  [4]
4-Iodoacetamidophenylacetylene
 Probe Info  		N.A.  LDD0038  [5]
IA-alkyne
 Probe Info  		C195(0.00); C354(0.00); C19(0.00); C249(0.00)  LDD0036  [5]
Lodoacetamide azide
 Probe Info  		C195(0.00); C354(0.00); C19(0.00); C249(0.00)  LDD0037  [5]
NAIA_4
 Probe Info  		N.A.  LDD2226  [6]
IPM
 Probe Info  		N.A.  LDD2156  [7]
AOyne
 Probe Info  		12.60  LDD0443  [8]
NAIA_5
 Probe Info  		C249(0.00); C354(0.00); C435(0.00)  LDD2223  [6]
PAL-AfBPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C246
 Probe Info  		12.38  LDD1919  [9]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0026  4SU-RNA+native RNA DM93 C542(2.56)  LDD0171  [4]
 LDCM0214  AC1 HEK-293T C195(1.08); C542(1.06); C19(0.95); C435(1.09)  LDD1507  [10]
 LDCM0215  AC10 HEK-293T C195(1.07); C542(0.94); C19(0.94); C435(0.99)  LDD1508  [10]
 LDCM0226  AC11 HEK-293T C195(1.01); C542(1.06); C19(0.98); C435(0.95)  LDD1509  [10]
 LDCM0237  AC12 HEK-293T C195(1.13); C19(0.92); C435(1.09); C354(1.15)  LDD1510  [10]
 LDCM0259  AC14 HEK-293T C195(1.02); C542(0.83); C19(0.96); C435(1.00)  LDD1512  [10]
 LDCM0270  AC15 HEK-293T C195(0.94); C542(1.12); C19(1.00); C435(0.90)  LDD1513  [10]
 LDCM0276  AC17 HEK-293T C195(1.13); C542(1.15); C19(1.01); C435(1.08)  LDD1515  [10]
 LDCM0277  AC18 HEK-293T C195(1.06); C542(0.89); C19(0.95); C435(0.94)  LDD1516  [10]
 LDCM0278  AC19 HEK-293T C195(1.23); C542(1.26); C19(1.26); C435(1.10)  LDD1517  [10]
 LDCM0279  AC2 HEK-293T C195(1.02); C542(1.19); C19(1.03); C435(1.00)  LDD1518  [10]
 LDCM0280  AC20 HEK-293T C195(1.11); C19(1.05); C435(1.03); C354(1.04)  LDD1519  [10]
 LDCM0281  AC21 HEK-293T C195(1.17); C542(1.01); C19(1.03); C435(0.91)  LDD1520  [10]
 LDCM0282  AC22 HEK-293T C195(1.04); C542(0.94); C19(0.97); C435(1.04)  LDD1521  [10]
 LDCM0283  AC23 HEK-293T C195(0.89); C542(1.01); C19(1.01); C435(1.00)  LDD1522  [10]
 LDCM0284  AC24 HEK-293T C195(1.02); C542(0.95); C19(0.93); C435(0.86)  LDD1523  [10]
 LDCM0285  AC25 HEK-293T C195(1.11); C542(0.98); C19(0.93); C435(0.99)  LDD1524  [10]
 LDCM0286  AC26 HEK-293T C195(0.99); C542(1.07); C19(0.91); C435(1.00)  LDD1525  [10]
 LDCM0287  AC27 HEK-293T C195(0.98); C542(0.98); C19(0.97); C435(1.06)  LDD1526  [10]
 LDCM0288  AC28 HEK-293T C195(1.05); C19(0.98); C435(1.00); C354(1.10)  LDD1527  [10]
 LDCM0289  AC29 HEK-293T C195(1.10); C542(1.13); C19(0.99); C435(0.90)  LDD1528  [10]
 LDCM0290  AC3 HEK-293T C195(1.14); C542(1.14); C19(0.92); C435(0.98)  LDD1529  [10]
 LDCM0291  AC30 HEK-293T C195(1.03); C542(1.08); C19(0.96); C435(1.02)  LDD1530  [10]
 LDCM0292  AC31 HEK-293T C195(0.94); C542(0.95); C19(1.02); C435(0.83)  LDD1531  [10]
 LDCM0293  AC32 HEK-293T C195(1.13); C542(1.17); C19(1.01); C435(0.98)  LDD1532  [10]
 LDCM0294  AC33 HEK-293T C195(1.10); C542(1.06); C19(0.94); C435(1.09)  LDD1533  [10]
 LDCM0295  AC34 HEK-293T C195(1.04); C542(1.10); C19(0.96); C435(1.08)  LDD1534  [10]
 LDCM0296  AC35 HEK-293T C195(0.98); C542(0.96); C19(0.94); C435(0.88)  LDD1535  [10]
 LDCM0297  AC36 HEK-293T C195(1.09); C19(0.98); C435(1.05); C354(1.00)  LDD1536  [10]
 LDCM0298  AC37 HEK-293T C195(1.06); C542(0.99); C19(1.07); C435(1.07)  LDD1537  [10]
 LDCM0299  AC38 HEK-293T C195(0.96); C542(1.02); C19(1.04); C435(0.96)  LDD1538  [10]
 LDCM0300  AC39 HEK-293T C195(1.00); C542(1.09); C19(1.03); C435(0.98)  LDD1539  [10]
 LDCM0301  AC4 HEK-293T C195(1.16); C19(0.97); C435(0.99); C354(1.11)  LDD1540  [10]
 LDCM0302  AC40 HEK-293T C195(1.05); C542(1.06); C19(1.03); C435(0.93)  LDD1541  [10]
 LDCM0303  AC41 HEK-293T C195(1.17); C542(1.05); C19(0.99); C435(1.26)  LDD1542  [10]
 LDCM0304  AC42 HEK-293T C195(1.09); C542(1.18); C19(0.86); C435(0.92)  LDD1543  [10]
 LDCM0305  AC43 HEK-293T C195(1.05); C542(1.15); C19(1.05); C435(0.94)  LDD1544  [10]
 LDCM0306  AC44 HEK-293T C195(1.13); C19(0.89); C435(1.02); C354(1.09)  LDD1545  [10]
 LDCM0307  AC45 HEK-293T C195(1.17); C542(0.93); C19(1.05); C435(0.97)  LDD1546  [10]
 LDCM0308  AC46 HEK-293T C195(1.03); C542(1.03); C19(0.96); C435(1.05)  LDD1547  [10]
 LDCM0309  AC47 HEK-293T C195(1.00); C542(1.12); C19(1.04); C435(1.05)  LDD1548  [10]
 LDCM0310  AC48 HEK-293T C195(1.12); C542(1.07); C19(1.01); C435(0.97)  LDD1549  [10]
 LDCM0311  AC49 HEK-293T C195(1.19); C542(1.04); C19(1.00); C435(0.96)  LDD1550  [10]
 LDCM0312  AC5 HEK-293T C195(1.04); C542(1.19); C19(1.06); C435(1.02)  LDD1551  [10]
 LDCM0313  AC50 HEK-293T C195(1.09); C542(1.04); C19(0.99); C435(1.07)  LDD1552  [10]
 LDCM0314  AC51 HEK-293T C195(0.99); C542(1.14); C19(0.95); C435(0.90)  LDD1553  [10]
 LDCM0315  AC52 HEK-293T C195(1.12); C19(0.91); C435(0.86); C354(0.98)  LDD1554  [10]
 LDCM0316  AC53 HEK-293T C195(1.03); C542(1.34); C19(0.98); C435(1.07)  LDD1555  [10]
 LDCM0317  AC54 HEK-293T C195(1.09); C542(1.10); C19(0.94); C435(0.93)  LDD1556  [10]
 LDCM0318  AC55 HEK-293T C195(1.04); C542(1.03); C19(1.01); C435(0.98)  LDD1557  [10]
 LDCM0319  AC56 HEK-293T C195(1.13); C542(0.96); C19(1.06); C435(1.03)  LDD1558  [10]
 LDCM0320  AC57 HEK-293T C195(1.07); C542(1.10); C19(1.03); C435(1.14)  LDD1559  [10]
 LDCM0321  AC58 HEK-293T C195(0.99); C542(1.00); C19(1.00); C435(0.99)  LDD1560  [10]
 LDCM0322  AC59 HEK-293T C195(1.01); C542(1.02); C19(0.92); C435(1.06)  LDD1561  [10]
 LDCM0323  AC6 HEK-293T C195(1.11); C542(0.88); C19(1.02); C435(1.03)  LDD1562  [10]
 LDCM0324  AC60 HEK-293T C195(1.05); C19(0.89); C435(1.00); C354(1.00)  LDD1563  [10]
 LDCM0325  AC61 HEK-293T C195(1.04); C542(1.06); C19(0.98); C435(0.96)  LDD1564  [10]
 LDCM0326  AC62 HEK-293T C195(0.98); C542(0.99); C19(0.96); C435(1.02)  LDD1565  [10]
 LDCM0327  AC63 HEK-293T C195(1.02); C542(1.07); C19(1.06); C435(1.04)  LDD1566  [10]
 LDCM0328  AC64 HEK-293T C195(1.04); C542(1.04); C19(0.97); C435(0.85)  LDD1567  [10]
 LDCM0334  AC7 HEK-293T C195(1.04); C542(1.00); C19(1.05); C435(0.98)  LDD1568  [10]
 LDCM0345  AC8 HEK-293T C195(1.12); C542(1.02); C19(1.02); C435(1.03)  LDD1569  [10]
 LDCM0248  AKOS034007472 HEK-293T C195(1.06); C542(0.93); C19(0.96); C435(0.92)  LDD1511  [10]
 LDCM0356  AKOS034007680 HEK-293T C195(1.03); C542(1.04); C19(0.99); C435(1.06)  LDD1570  [10]
 LDCM0275  AKOS034007705 HEK-293T C195(1.05); C542(0.99); C19(0.96); C435(1.08)  LDD1514  [10]
 LDCM0156  Aniline NCI-H1299 12.41  LDD0403  [2]
 LDCM0632  CL-Sc Hep-G2 C435(20.00)  LDD2227  [6]
 LDCM0367  CL1 HEK-293T C195(1.08); C542(1.00); C19(0.94); C435(1.06)  LDD1571  [10]
 LDCM0368  CL10 HEK-293T C195(1.02); C542(1.12); C19(0.95); C435(0.96)  LDD1572  [10]
 LDCM0369  CL100 HEK-293T C195(1.05); C542(1.00); C19(0.95); C435(0.96)  LDD1573  [10]
 LDCM0370  CL101 HEK-293T C195(1.07); C542(1.12); C19(0.96); C435(1.25)  LDD1574  [10]
 LDCM0371  CL102 HEK-293T C195(0.99); C542(1.02); C19(0.80); C435(1.04)  LDD1575  [10]
 LDCM0372  CL103 HEK-293T C195(1.04); C542(1.07); C19(0.96); C435(1.12)  LDD1576  [10]
 LDCM0373  CL104 HEK-293T C195(1.03); C542(1.10); C19(0.96); C435(1.03)  LDD1577  [10]
 LDCM0374  CL105 HEK-293T C195(1.11); C542(0.86); C19(0.95); C435(1.13)  LDD1578  [10]
 LDCM0375  CL106 HEK-293T C195(0.97); C542(1.02); C19(1.05); C435(0.96)  LDD1579  [10]
 LDCM0376  CL107 HEK-293T C195(1.09); C542(1.01); C19(0.93); C435(1.04)  LDD1580  [10]
 LDCM0377  CL108 HEK-293T C195(1.03); C542(0.99); C19(0.98); C435(0.96)  LDD1581  [10]
 LDCM0378  CL109 HEK-293T C195(1.11); C542(0.97); C19(0.99); C435(0.95)  LDD1582  [10]
 LDCM0379  CL11 HEK-293T C195(0.92); C542(1.23); C19(1.11); C435(0.97)  LDD1583  [10]
 LDCM0380  CL110 HEK-293T C195(0.95); C542(1.01); C19(1.07); C435(0.87)  LDD1584  [10]
 LDCM0381  CL111 HEK-293T C195(1.01); C542(0.97); C19(0.93); C435(0.97)  LDD1585  [10]
 LDCM0382  CL112 HEK-293T C195(1.07); C542(1.03); C19(0.94); C435(1.01)  LDD1586  [10]
 LDCM0383  CL113 HEK-293T C195(0.97); C542(0.99); C19(1.06); C435(1.11)  LDD1587  [10]
 LDCM0384  CL114 HEK-293T C195(1.12); C542(1.04); C19(0.77); C435(0.91)  LDD1588  [10]
 LDCM0385  CL115 HEK-293T C195(1.03); C542(1.01); C19(0.94); C435(0.94)  LDD1589  [10]
 LDCM0386  CL116 HEK-293T C195(1.10); C542(1.03); C19(0.94); C435(1.00)  LDD1590  [10]
 LDCM0387  CL117 HEK-293T C195(0.99); C542(0.92); C19(1.01); C435(1.00)  LDD1591  [10]
 LDCM0388  CL118 HEK-293T C195(1.08); C542(1.04); C19(1.03); C435(1.08)  LDD1592  [10]
 LDCM0389  CL119 HEK-293T C195(1.02); C542(1.12); C19(1.04); C435(1.13)  LDD1593  [10]
 LDCM0390  CL12 HEK-293T C195(1.03); C542(1.16); C19(1.02); C435(0.95)  LDD1594  [10]
 LDCM0391  CL120 HEK-293T C195(1.18); C542(1.09); C19(0.98); C435(0.98)  LDD1595  [10]
 LDCM0392  CL121 HEK-293T C195(1.04); C542(0.99); C19(1.00); C435(1.14)  LDD1596  [10]
 LDCM0393  CL122 HEK-293T C195(1.09); C542(1.08); C19(0.91); C435(0.98)  LDD1597  [10]
 LDCM0394  CL123 HEK-293T C195(1.02); C542(1.03); C19(1.00); C435(1.04)  LDD1598  [10]
 LDCM0395  CL124 HEK-293T C195(1.13); C542(1.02); C19(1.02); C435(0.97)  LDD1599  [10]
 LDCM0396  CL125 HEK-293T C195(1.01); C542(0.91); C19(0.93); C435(1.10)  LDD1600  [10]
 LDCM0397  CL126 HEK-293T C195(1.01); C542(1.04); C19(1.00); C435(0.99)  LDD1601  [10]
 LDCM0398  CL127 HEK-293T C195(1.08); C542(1.01); C19(0.98); C435(0.99)  LDD1602  [10]
 LDCM0399  CL128 HEK-293T C195(1.10); C542(1.03); C19(1.00); C435(0.97)  LDD1603  [10]
 LDCM0400  CL13 HEK-293T C195(1.09); C542(1.11); C19(0.97); C435(0.94)  LDD1604  [10]
 LDCM0401  CL14 HEK-293T C195(0.89); C542(1.04); C19(0.97); C435(1.00)  LDD1605  [10]
 LDCM0402  CL15 HEK-293T C195(1.09); C542(1.01); C19(1.01); C435(1.06)  LDD1606  [10]
 LDCM0403  CL16 HEK-293T C195(1.04); C542(1.26); C19(0.94); C435(1.04)  LDD1607  [10]
 LDCM0404  CL17 HEK-293T C195(1.14); C542(1.11); C19(1.03); C435(1.07)  LDD1608  [10]
 LDCM0405  CL18 HEK-293T C195(0.94); C542(1.06); C19(0.94); C435(0.98)  LDD1609  [10]
 LDCM0406  CL19 HEK-293T C195(1.08); C542(1.00); C19(1.04); C435(0.92)  LDD1610  [10]
 LDCM0407  CL2 HEK-293T C195(0.98); C542(1.03); C19(0.94); C435(1.03)  LDD1611  [10]
 LDCM0408  CL20 HEK-293T C195(1.06); C19(1.06); C435(1.03); C354(1.08)  LDD1612  [10]
 LDCM0409  CL21 HEK-293T C195(1.10); C542(0.98); C19(0.99); C435(0.96)  LDD1613  [10]
 LDCM0410  CL22 HEK-293T C195(0.97); C542(1.31); C19(1.02); C435(1.05)  LDD1614  [10]
 LDCM0411  CL23 HEK-293T C195(0.93); C542(1.13); C19(1.13); C435(1.22)  LDD1615  [10]
 LDCM0412  CL24 HEK-293T C195(1.01); C542(1.09); C19(0.95); C435(0.90)  LDD1616  [10]
 LDCM0413  CL25 HEK-293T C195(1.04); C542(1.11); C19(0.96); C435(0.93)  LDD1617  [10]
 LDCM0414  CL26 HEK-293T C195(0.95); C542(0.99); C19(0.94); C435(1.00)  LDD1618  [10]
 LDCM0415  CL27 HEK-293T C195(1.00); C542(1.02); C19(0.97); C435(1.09)  LDD1619  [10]
 LDCM0416  CL28 HEK-293T C195(1.09); C542(0.95); C19(1.01); C435(1.03)  LDD1620  [10]
 LDCM0417  CL29 HEK-293T C195(1.11); C542(1.03); C19(1.03); C435(1.00)  LDD1621  [10]
 LDCM0418  CL3 HEK-293T C195(0.94); C542(1.17); C19(1.03); C435(1.04)  LDD1622  [10]
 LDCM0419  CL30 HEK-293T C195(1.02); C542(1.11); C19(0.98); C435(1.03)  LDD1623  [10]
 LDCM0420  CL31 HEK-293T C195(1.04); C542(1.10); C19(0.93); C435(1.08)  LDD1624  [10]
 LDCM0421  CL32 HEK-293T C195(1.15); C19(0.99); C435(0.97); C354(1.12)  LDD1625  [10]
 LDCM0422  CL33 HEK-293T C195(1.09); C542(1.07); C19(1.05); C435(1.05)  LDD1626  [10]
 LDCM0423  CL34 HEK-293T C195(0.94); C542(0.90); C19(1.01); C435(0.95)  LDD1627  [10]
 LDCM0424  CL35 HEK-293T C195(0.91); C542(1.07); C19(1.16); C435(0.97)  LDD1628  [10]
 LDCM0425  CL36 HEK-293T C195(0.87); C542(1.17); C19(1.10); C435(0.91)  LDD1629  [10]
 LDCM0426  CL37 HEK-293T C195(1.03); C542(1.02); C19(0.99); C435(1.04)  LDD1630  [10]
 LDCM0428  CL39 HEK-293T C195(0.99); C542(1.03); C19(0.97); C435(1.02)  LDD1632  [10]
 LDCM0429  CL4 HEK-293T C195(0.95); C542(1.72); C19(0.97); C435(0.97)  LDD1633  [10]
 LDCM0430  CL40 HEK-293T C195(1.01); C542(1.02); C19(1.07); C435(0.99)  LDD1634  [10]
 LDCM0431  CL41 HEK-293T C195(1.08); C542(1.04); C19(0.99); C435(0.99)  LDD1635  [10]
 LDCM0432  CL42 HEK-293T C195(1.00); C542(1.26); C19(1.01); C435(0.93)  LDD1636  [10]
 LDCM0433  CL43 HEK-293T C195(1.03); C542(0.97); C19(1.05); C435(0.94)  LDD1637  [10]
 LDCM0434  CL44 HEK-293T C195(0.99); C19(1.02); C435(1.00); C354(1.14)  LDD1638  [10]
 LDCM0435  CL45 HEK-293T C195(1.12); C542(1.07); C19(0.98); C435(1.06)  LDD1639  [10]
 LDCM0436  CL46 HEK-293T C195(0.93); C542(1.09); C19(0.99); C435(1.04)  LDD1640  [10]
 LDCM0437  CL47 HEK-293T C195(0.86); C542(1.17); C19(1.10); C435(0.94)  LDD1641  [10]
 LDCM0438  CL48 HEK-293T C195(0.94); C542(1.07); C19(1.07); C435(1.13)  LDD1642  [10]
 LDCM0439  CL49 HEK-293T C195(1.12); C542(0.94); C19(1.09); C435(1.17)  LDD1643  [10]
 LDCM0440  CL5 HEK-293T C195(1.14); C542(1.14); C19(0.99); C435(1.13)  LDD1644  [10]
 LDCM0441  CL50 HEK-293T C195(0.99); C542(1.04); C19(0.93); C435(1.02)  LDD1645  [10]
 LDCM0443  CL52 HEK-293T C195(1.09); C542(0.96); C19(1.01); C435(1.01)  LDD1646  [10]
 LDCM0444  CL53 HEK-293T C195(1.05); C542(1.02); C19(1.01); C435(0.99)  LDD1647  [10]
 LDCM0445  CL54 HEK-293T C195(1.01); C542(1.08); C19(1.13); C435(0.85)  LDD1648  [10]
 LDCM0446  CL55 HEK-293T C195(1.00); C542(1.03); C19(1.03); C435(0.83)  LDD1649  [10]
 LDCM0447  CL56 HEK-293T C195(0.98); C19(0.93); C435(0.92); C354(1.07)  LDD1650  [10]
 LDCM0448  CL57 HEK-293T C195(1.09); C542(0.92); C19(1.04); C435(0.95)  LDD1651  [10]
 LDCM0449  CL58 HEK-293T C195(0.98); C542(1.00); C19(1.08); C435(1.09)  LDD1652  [10]
 LDCM0450  CL59 HEK-293T C195(0.91); C542(1.33); C19(1.23); C435(0.90)  LDD1653  [10]
 LDCM0451  CL6 HEK-293T C195(0.97); C542(0.92); C19(0.67); C435(0.97)  LDD1654  [10]
 LDCM0452  CL60 HEK-293T C195(0.98); C542(1.10); C19(1.11); C435(1.00)  LDD1655  [10]
 LDCM0453  CL61 HEK-293T C195(1.11); C542(1.04); C19(1.10); C435(1.09)  LDD1656  [10]
 LDCM0454  CL62 HEK-293T C195(1.06); C542(1.19); C19(0.84); C435(0.97)  LDD1657  [10]
 LDCM0455  CL63 HEK-293T C195(1.10); C542(1.00); C19(0.98); C435(1.07)  LDD1658  [10]
 LDCM0456  CL64 HEK-293T C195(1.14); C542(0.95); C19(0.99); C435(1.02)  LDD1659  [10]
 LDCM0457  CL65 HEK-293T C195(1.09); C542(1.15); C19(1.04); C435(1.12)  LDD1660  [10]
 LDCM0458  CL66 HEK-293T C195(0.92); C542(0.93); C19(0.90); C435(0.99)  LDD1661  [10]
 LDCM0459  CL67 HEK-293T C195(1.08); C542(0.97); C19(1.02); C435(0.98)  LDD1662  [10]
 LDCM0460  CL68 HEK-293T C195(1.01); C19(0.93); C435(0.91); C354(1.04)  LDD1663  [10]
 LDCM0461  CL69 HEK-293T C195(1.03); C542(0.93); C19(1.10); C435(0.98)  LDD1664  [10]
 LDCM0462  CL7 HEK-293T C195(0.99); C542(0.99); C19(0.98); C435(1.00)  LDD1665  [10]
 LDCM0463  CL70 HEK-293T C195(0.99); C542(1.15); C19(1.01); C435(1.07)  LDD1666  [10]
 LDCM0464  CL71 HEK-293T C195(0.93); C542(1.29); C19(1.06); C435(1.06)  LDD1667  [10]
 LDCM0465  CL72 HEK-293T C195(0.98); C542(1.25); C19(1.02); C435(1.46)  LDD1668  [10]
 LDCM0466  CL73 HEK-293T C195(0.98); C542(1.02); C19(0.97); C435(1.06)  LDD1669  [10]
 LDCM0467  CL74 HEK-293T C195(0.99); C542(1.02); C19(0.98); C435(1.00)  LDD1670  [10]
 LDCM0469  CL76 HEK-293T C195(1.00); C542(1.00); C19(1.03); C435(1.02)  LDD1672  [10]
 LDCM0470  CL77 HEK-293T C195(1.08); C542(1.03); C19(0.98); C435(0.99)  LDD1673  [10]
 LDCM0471  CL78 HEK-293T C195(0.97); C542(1.07); C19(0.88); C435(0.98)  LDD1674  [10]
 LDCM0472  CL79 HEK-293T C195(1.16); C542(1.13); C19(0.98); C435(1.00)  LDD1675  [10]
 LDCM0473  CL8 HEK-293T C195(1.12); C19(0.97); C435(0.92); C354(1.06)  LDD1676  [10]
 LDCM0474  CL80 HEK-293T C195(1.07); C19(0.99); C435(1.03); C354(1.05)  LDD1677  [10]
 LDCM0475  CL81 HEK-293T C195(1.04); C542(1.07); C19(1.00); C435(0.99)  LDD1678  [10]
 LDCM0476  CL82 HEK-293T C195(1.05); C542(0.96); C19(1.01); C435(1.02)  LDD1679  [10]
 LDCM0477  CL83 HEK-293T C195(0.84); C542(1.20); C19(1.02); C435(0.91)  LDD1680  [10]
 LDCM0478  CL84 HEK-293T C195(0.91); C542(1.14); C19(1.18); C435(0.84)  LDD1681  [10]
 LDCM0479  CL85 HEK-293T C195(1.07); C542(0.99); C19(1.04); C435(1.19)  LDD1682  [10]
 LDCM0480  CL86 HEK-293T C195(1.12); C542(1.01); C19(0.86); C435(1.05)  LDD1683  [10]
 LDCM0481  CL87 HEK-293T C195(1.12); C542(1.04); C19(0.97); C435(1.03)  LDD1684  [10]
 LDCM0482  CL88 HEK-293T C195(1.05); C542(1.13); C19(0.99); C435(0.96)  LDD1685  [10]
 LDCM0483  CL89 HEK-293T C195(1.14); C542(1.17); C19(1.01); C435(1.14)  LDD1686  [10]
 LDCM0484  CL9 HEK-293T C195(1.02); C542(0.97); C19(1.07); C435(1.01)  LDD1687  [10]
 LDCM0485  CL90 HEK-293T C195(1.09); C542(1.18); C19(1.06); C435(0.89)  LDD1688  [10]
 LDCM0486  CL91 HEK-293T C195(1.04); C542(0.91); C19(1.13); C435(1.04)  LDD1689  [10]
 LDCM0487  CL92 HEK-293T C195(1.04); C19(0.91); C435(0.95); C354(1.18)  LDD1690  [10]
 LDCM0488  CL93 HEK-293T C195(1.00); C542(0.88); C19(1.06); C435(0.94)  LDD1691  [10]
 LDCM0489  CL94 HEK-293T C195(0.90); C542(0.96); C19(0.99); C435(0.89)  LDD1692  [10]
 LDCM0490  CL95 HEK-293T C195(0.99); C542(1.29); C19(0.86); C435(0.99)  LDD1693  [10]
 LDCM0491  CL96 HEK-293T C195(1.07); C542(1.08); C19(1.06); C435(0.88)  LDD1694  [10]
 LDCM0492  CL97 HEK-293T C195(0.97); C542(0.97); C19(1.01); C435(1.17)  LDD1695  [10]
 LDCM0493  CL98 HEK-293T C195(1.07); C542(1.10); C19(1.02); C435(1.05)  LDD1696  [10]
 LDCM0494  CL99 HEK-293T C195(1.03); C542(0.99); C19(0.99); C435(1.06)  LDD1697  [10]
 LDCM0495  E2913 HEK-293T C195(1.06); C542(1.00); C19(1.01); C435(0.99)  LDD1698  [10]
 LDCM0468  Fragment33 HEK-293T C195(0.97); C542(1.11); C19(0.98); C435(0.96)  LDD1671  [10]
 LDCM0427  Fragment51 HEK-293T C195(1.15); C542(1.06); C19(0.86); C435(0.90)  LDD1631  [10]
 LDCM0022  KB02 HEK-293T C195(0.81); C19(0.95); C435(1.01); C354(0.91)  LDD1492  [10]
 LDCM0023  KB03 HEK-293T C195(0.99); C19(0.99); C435(0.94); C354(1.00)  LDD1497  [10]
 LDCM0024  KB05 RAW264.7 C94(1.55)  LDD3329  [3]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 3 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Integrator complex subunit 9 (INTS9) RNA-metabolizing metallo-beta-lactamase-like family Q9NV88
Ubiquitin carboxyl-terminal hydrolase 2 (USP2) Peptidase C19 family O75604
Serine/threonine-protein kinase N1 (PKN1) AGC Ser/Thr protein kinase family Q16512
Transporter and channel
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Phospholipid scramblase 4 (PLSCR4) Phospholipid scramblase family Q9NRQ2
Transcription factor
Click To Hide/Show 7 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Transcription factor Spi-C (SPIC) ETS family Q8N5J4
Zinc finger protein ZIC 1 (ZIC1) GLI C2H2-type zinc-finger protein family Q15915
Homeobox protein prophet of Pit-1 (PROP1) Paired homeobox family O75360
Homeobox protein OTX1 (OTX1) Paired homeobox family P32242
Homeobox protein VENTX (VENTX) . O95231
T-box transcription factor TBX6 (TBX6) . O95947
T-cell leukemia homeobox protein 3 (TLX3) . O43711
GPCR
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Oxoeicosanoid receptor 1 (OXER1) G-protein coupled receptor 1 family Q8TDS5
Other
Click To Hide/Show 12 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Protein FAM222B (FAM222B) FAM222 family Q8WU58
Keratin-associated protein 15-1 (KRTAP15-1) PMG family Q3LI76
Keratin-associated protein 26-1 (KRTAP26-1) PMG family Q6PEX3
U1 small nuclear ribonucleoprotein C (SNRPC) U1 small nuclear ribonucleoprotein C family P09234
Protein VAC14 homolog (VAC14) VAC14 family Q08AM6
Coiled-coil domain-containing protein 120 (CCDC120) . Q96HB5
G protein pathway suppressor 2 (GPS2) . Q13227
Leukocyte receptor cluster member 8 (LENG8) . Q96PV6
Proline-rich protein 35 (PRR35) . P0CG20
Protein TFG (TFG) . Q92734
Uncharacterized protein C1orf94 (C1orf94) . Q6P1W5
Zinc finger CCCH domain-containing protein 10 (ZC3H10) . Q96K80

References

1 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
2 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
3 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
4 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
5 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
6 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
7 Benchmarking Cleavable Biotin Tags for Peptide-Centric Chemoproteomics. J Proteome Res. 2022 May 6;21(5):1349-1358. doi: 10.1021/acs.jproteome.2c00174. Epub 2022 Apr 25.
Mass spectrometry data entry: PXD031019
8 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
9 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587
10 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402