Details of the Target

General Information of Target

Target ID LDTP07106
Target Name MAGUK p55 subfamily member 7 (MPP7)
Gene Name MPP7
Gene ID 143098
Synonyms
MAGUK p55 subfamily member 7
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MPALSTGSGSDTGLYELLAALPAQLQPHVDSQEDLTFLWDMFGEKSLHSLVKIHEKLHYY
EKQSPVPILHGAAALADDLAEELQNKPLNSEIRELLKLLSKPNVKALLSVHDTVAQKNYD
PVLPPMPEDIDDEEDSVKIIRLVKNREPLGATIKKDEQTGAIIVARIMRGGAADRSGLIH
VGDELREVNGIPVEDKRPEEIIQILAQSQGAITFKIIPGSKEETPSKEGKMFIKALFDYN
PNEDKAIPCKEAGLSFKKGDILQIMSQDDATWWQAKHEADANPRAGLIPSKHFQERRLAL
RRPEILVQPLKVSNRKSSGFRKSFRLSRKDKKTNKSMYECKKSDQYDTADVPTYEEVTPY
RRQTNEKYRLVVLVGPVGVGLNELKRKLLISDTQHYGVTVPHTTRARRSQESDGVEYIFI
SKHLFETDVQNNKFIEYGEYKNNYYGTSIDSVRSVLAKNKVCLLDVQPHTVKHLRTLEFK
PYVIFIKPPSIERLRETRKNAKIISSRDDQGAAKPFTEEDFQEMIKSAQIMESQYGHLFD
KIIINDDLTVAFNELKTTFDKLETETHWVPVSWLHS
Target Bioclass
Other
Family
MAGUK family
Subcellular location
Membrane
Function
Acts as an important adapter that promotes epithelial cell polarity and tight junction formation via its interaction with DLG1. Involved in the assembly of protein complexes at sites of cell-cell contact.
Uniprot ID
Q5T2T1
Ensemble ID
ENST00000337532.9
HGNC ID
HGNC:26542

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
EGI1 Substitution: p.A211L .
HT115 SNV: p.D129Y .
HUPT3 Insertion: p.P87KfsTer4 .
IGR1 SNV: p.G7E .
NCIH146 SNV: p.R297I .
NCIH358 Insertion: p.P87KfsTer4 .
PC9 SNV: p.K105N .
T98G SNV: p.D546N .
WM2664 Insertion: p.Q158PfsTer18 .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 8 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
Probe 1
 Probe Info  		Y437(14.06); Y440(15.09); Y445(11.07)  LDD3495  [1]
DBIA
 Probe Info  		C462(1.22)  LDD0531  [2]
IA-alkyne
 Probe Info  		C462(0.00); C340(0.00)  LDD0165  [3]
IPM
 Probe Info  		N.A.  LDD0147  [4]
TFBX
 Probe Info  		N.A.  LDD0148  [4]
Phosphinate-6
 Probe Info  		N.A.  LDD0018  [5]
AOyne
 Probe Info  		12.90  LDD0443  [6]
NAIA_5
 Probe Info  		N.A.  LDD2223  [7]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HCT 116 C462(1.22)  LDD0531  [2]
 LDCM0215  AC10 HCT 116 C462(0.73)  LDD0532  [2]
 LDCM0216  AC100 HCT 116 C462(0.41)  LDD0533  [2]
 LDCM0217  AC101 HCT 116 C462(0.49)  LDD0534  [2]
 LDCM0218  AC102 HCT 116 C462(0.41)  LDD0535  [2]
 LDCM0219  AC103 HCT 116 C462(0.29)  LDD0536  [2]
 LDCM0220  AC104 HCT 116 C462(0.31)  LDD0537  [2]
 LDCM0221  AC105 HCT 116 C462(0.29)  LDD0538  [2]
 LDCM0222  AC106 HCT 116 C462(0.29)  LDD0539  [2]
 LDCM0223  AC107 HCT 116 C462(0.43)  LDD0540  [2]
 LDCM0224  AC108 HCT 116 C462(0.52)  LDD0541  [2]
 LDCM0225  AC109 HCT 116 C462(0.50)  LDD0542  [2]
 LDCM0226  AC11 HCT 116 C462(0.88)  LDD0543  [2]
 LDCM0227  AC110 HCT 116 C462(0.45)  LDD0544  [2]
 LDCM0228  AC111 HCT 116 C462(0.47)  LDD0545  [2]
 LDCM0229  AC112 HCT 116 C462(0.35)  LDD0546  [2]
 LDCM0237  AC12 HCT 116 C462(0.99)  LDD0554  [2]
 LDCM0246  AC128 HCT 116 C462(1.05)  LDD0563  [2]
 LDCM0247  AC129 HCT 116 C462(1.12)  LDD0564  [2]
 LDCM0249  AC130 HCT 116 C462(0.98)  LDD0566  [2]
 LDCM0250  AC131 HCT 116 C462(1.16)  LDD0567  [2]
 LDCM0251  AC132 HCT 116 C462(1.12)  LDD0568  [2]
 LDCM0252  AC133 HCT 116 C462(1.06)  LDD0569  [2]
 LDCM0253  AC134 HCT 116 C462(1.01)  LDD0570  [2]
 LDCM0254  AC135 HCT 116 C462(0.95)  LDD0571  [2]
 LDCM0255  AC136 HCT 116 C462(0.96)  LDD0572  [2]
 LDCM0256  AC137 HCT 116 C462(1.09)  LDD0573  [2]
 LDCM0257  AC138 HCT 116 C462(0.94)  LDD0574  [2]
 LDCM0258  AC139 HCT 116 C462(0.95)  LDD0575  [2]
 LDCM0259  AC14 HCT 116 C462(0.99)  LDD0576  [2]
 LDCM0260  AC140 HCT 116 C462(0.85)  LDD0577  [2]
 LDCM0261  AC141 HCT 116 C462(0.91)  LDD0578  [2]
 LDCM0262  AC142 HCT 116 C462(1.59)  LDD0579  [2]
 LDCM0270  AC15 HCT 116 C462(0.73)  LDD0587  [2]
 LDCM0279  AC2 HCT 116 C462(1.13)  LDD0596  [2]
 LDCM0285  AC25 HCT 116 C462(0.83)  LDD0602  [2]
 LDCM0286  AC26 HCT 116 C462(0.79)  LDD0603  [2]
 LDCM0287  AC27 HCT 116 C462(0.65)  LDD0604  [2]
 LDCM0288  AC28 HCT 116 C462(0.66)  LDD0605  [2]
 LDCM0289  AC29 HCT 116 C462(0.76)  LDD0606  [2]
 LDCM0290  AC3 HCT 116 C462(1.10)  LDD0607  [2]
 LDCM0291  AC30 HCT 116 C462(0.70)  LDD0608  [2]
 LDCM0292  AC31 HCT 116 C462(0.74)  LDD0609  [2]
 LDCM0293  AC32 HCT 116 C462(0.56)  LDD0610  [2]
 LDCM0294  AC33 HCT 116 C462(0.57)  LDD0611  [2]
 LDCM0295  AC34 HCT 116 C462(0.53)  LDD0612  [2]
 LDCM0296  AC35 HCT 116 C462(1.37)  LDD0613  [2]
 LDCM0297  AC36 HCT 116 C462(1.25)  LDD0614  [2]
 LDCM0298  AC37 HCT 116 C462(1.35)  LDD0615  [2]
 LDCM0299  AC38 HCT 116 C462(1.08)  LDD0616  [2]
 LDCM0300  AC39 HCT 116 C462(0.96)  LDD0617  [2]
 LDCM0301  AC4 HCT 116 C462(1.10)  LDD0618  [2]
 LDCM0302  AC40 HCT 116 C462(1.06)  LDD0619  [2]
 LDCM0303  AC41 HCT 116 C462(1.00)  LDD0620  [2]
 LDCM0304  AC42 HCT 116 C462(1.02)  LDD0621  [2]
 LDCM0305  AC43 HCT 116 C462(1.04)  LDD0622  [2]
 LDCM0306  AC44 HCT 116 C462(1.11)  LDD0623  [2]
 LDCM0307  AC45 HCT 116 C462(1.02)  LDD0624  [2]
 LDCM0308  AC46 HCT 116 C462(1.17)  LDD0625  [2]
 LDCM0309  AC47 HCT 116 C462(0.89)  LDD0626  [2]
 LDCM0310  AC48 HCT 116 C462(1.16)  LDD0627  [2]
 LDCM0311  AC49 HCT 116 C462(0.92)  LDD0628  [2]
 LDCM0312  AC5 HCT 116 C462(1.15)  LDD0629  [2]
 LDCM0313  AC50 HCT 116 C462(0.98)  LDD0630  [2]
 LDCM0314  AC51 HCT 116 C462(1.43)  LDD0631  [2]
 LDCM0315  AC52 HCT 116 C462(0.95)  LDD0632  [2]
 LDCM0316  AC53 HCT 116 C462(0.92)  LDD0633  [2]
 LDCM0317  AC54 HCT 116 C462(1.00)  LDD0634  [2]
 LDCM0318  AC55 HCT 116 C462(0.92)  LDD0635  [2]
 LDCM0319  AC56 HCT 116 C462(1.12)  LDD0636  [2]
 LDCM0320  AC57 HCT 116 C462(0.56)  LDD0637  [2]
 LDCM0321  AC58 HCT 116 C462(0.57)  LDD0638  [2]
 LDCM0322  AC59 HCT 116 C462(0.54)  LDD0639  [2]
 LDCM0323  AC6 HCT 116 C462(0.69)  LDD0640  [2]
 LDCM0324  AC60 HCT 116 C462(0.65)  LDD0641  [2]
 LDCM0325  AC61 HCT 116 C462(0.83)  LDD0642  [2]
 LDCM0326  AC62 HCT 116 C462(0.57)  LDD0643  [2]
 LDCM0327  AC63 HCT 116 C462(0.66)  LDD0644  [2]
 LDCM0328  AC64 HCT 116 C462(0.58)  LDD0645  [2]
 LDCM0329  AC65 HCT 116 C462(0.51)  LDD0646  [2]
 LDCM0330  AC66 HCT 116 C462(0.55)  LDD0647  [2]
 LDCM0331  AC67 HCT 116 C462(0.55)  LDD0648  [2]
 LDCM0332  AC68 HCT 116 C462(1.10)  LDD0649  [2]
 LDCM0333  AC69 HCT 116 C462(1.02)  LDD0650  [2]
 LDCM0334  AC7 HCT 116 C462(1.09)  LDD0651  [2]
 LDCM0335  AC70 HCT 116 C462(1.16)  LDD0652  [2]
 LDCM0336  AC71 HCT 116 C462(1.22)  LDD0653  [2]
 LDCM0337  AC72 HCT 116 C462(0.98)  LDD0654  [2]
 LDCM0338  AC73 HCT 116 C462(1.15)  LDD0655  [2]
 LDCM0339  AC74 HCT 116 C462(1.36)  LDD0656  [2]
 LDCM0340  AC75 HCT 116 C462(1.37)  LDD0657  [2]
 LDCM0341  AC76 HCT 116 C462(1.04)  LDD0658  [2]
 LDCM0342  AC77 HCT 116 C462(0.98)  LDD0659  [2]
 LDCM0343  AC78 HCT 116 C462(1.34)  LDD0660  [2]
 LDCM0344  AC79 HCT 116 C462(0.98)  LDD0661  [2]
 LDCM0345  AC8 HCT 116 C462(0.75)  LDD0662  [2]
 LDCM0346  AC80 HCT 116 C462(1.05)  LDD0663  [2]
 LDCM0347  AC81 HCT 116 C462(1.54)  LDD0664  [2]
 LDCM0348  AC82 HCT 116 C462(1.67)  LDD0665  [2]
 LDCM0349  AC83 HCT 116 C462(0.61)  LDD0666  [2]
 LDCM0350  AC84 HCT 116 C462(0.51)  LDD0667  [2]
 LDCM0351  AC85 HCT 116 C462(0.63)  LDD0668  [2]
 LDCM0352  AC86 HCT 116 C462(0.58)  LDD0669  [2]
 LDCM0353  AC87 HCT 116 C462(1.09)  LDD0670  [2]
 LDCM0354  AC88 HCT 116 C462(0.52)  LDD0671  [2]
 LDCM0355  AC89 HCT 116 C462(0.44)  LDD0672  [2]
 LDCM0357  AC90 HCT 116 C462(1.07)  LDD0674  [2]
 LDCM0358  AC91 HCT 116 C462(0.52)  LDD0675  [2]
 LDCM0359  AC92 HCT 116 C462(0.45)  LDD0676  [2]
 LDCM0360  AC93 HCT 116 C462(0.48)  LDD0677  [2]
 LDCM0361  AC94 HCT 116 C462(0.82)  LDD0678  [2]
 LDCM0362  AC95 HCT 116 C462(0.85)  LDD0679  [2]
 LDCM0363  AC96 HCT 116 C462(0.55)  LDD0680  [2]
 LDCM0364  AC97 HCT 116 C462(0.43)  LDD0681  [2]
 LDCM0365  AC98 HCT 116 C462(0.36)  LDD0682  [2]
 LDCM0366  AC99 HCT 116 C462(0.49)  LDD0683  [2]
 LDCM0248  AKOS034007472 HCT 116 C462(0.92)  LDD0565  [2]
 LDCM0356  AKOS034007680 HCT 116 C462(1.00)  LDD0673  [2]
 LDCM0275  AKOS034007705 HCT 116 C462(0.55)  LDD0592  [2]
 LDCM0367  CL1 HCT 116 C462(1.16)  LDD0684  [2]
 LDCM0368  CL10 HCT 116 C462(0.95)  LDD0685  [2]
 LDCM0369  CL100 HCT 116 C462(1.00)  LDD0686  [2]
 LDCM0370  CL101 HCT 116 C462(0.75)  LDD0687  [2]
 LDCM0371  CL102 HCT 116 C462(0.89)  LDD0688  [2]
 LDCM0372  CL103 HCT 116 C462(1.00)  LDD0689  [2]
 LDCM0373  CL104 HCT 116 C462(0.87)  LDD0690  [2]
 LDCM0379  CL11 HCT 116 C462(0.92)  LDD0696  [2]
 LDCM0382  CL112 HCT 116 C462(0.83)  LDD0699  [2]
 LDCM0383  CL113 HCT 116 C462(0.68)  LDD0700  [2]
 LDCM0384  CL114 HCT 116 C462(0.84)  LDD0701  [2]
 LDCM0385  CL115 HCT 116 C462(0.62)  LDD0702  [2]
 LDCM0386  CL116 HCT 116 C462(0.69)  LDD0703  [2]
 LDCM0387  CL117 HCT 116 C462(1.10)  LDD0704  [2]
 LDCM0388  CL118 HCT 116 C462(1.06)  LDD0705  [2]
 LDCM0389  CL119 HCT 116 C462(0.90)  LDD0706  [2]
 LDCM0390  CL12 HCT 116 C462(1.04)  LDD0707  [2]
 LDCM0391  CL120 HCT 116 C462(0.99)  LDD0708  [2]
 LDCM0392  CL121 HCT 116 C462(0.76)  LDD0709  [2]
 LDCM0393  CL122 HCT 116 C462(1.13)  LDD0710  [2]
 LDCM0394  CL123 HCT 116 C462(0.83)  LDD0711  [2]
 LDCM0395  CL124 HCT 116 C462(0.86)  LDD0712  [2]
 LDCM0396  CL125 HCT 116 C462(0.87)  LDD0713  [2]
 LDCM0397  CL126 HCT 116 C462(0.69)  LDD0714  [2]
 LDCM0398  CL127 HCT 116 C462(0.78)  LDD0715  [2]
 LDCM0399  CL128 HCT 116 C462(0.46)  LDD0716  [2]
 LDCM0400  CL13 HCT 116 C462(1.05)  LDD0717  [2]
 LDCM0401  CL14 HCT 116 C462(1.10)  LDD0718  [2]
 LDCM0402  CL15 HCT 116 C462(1.26)  LDD0719  [2]
 LDCM0403  CL16 HCT 116 C462(0.87)  LDD0720  [2]
 LDCM0404  CL17 HCT 116 C462(0.75)  LDD0721  [2]
 LDCM0405  CL18 HCT 116 C462(1.12)  LDD0722  [2]
 LDCM0406  CL19 HCT 116 C462(0.83)  LDD0723  [2]
 LDCM0407  CL2 HCT 116 C462(1.41)  LDD0724  [2]
 LDCM0408  CL20 HCT 116 C462(0.76)  LDD0725  [2]
 LDCM0409  CL21 HCT 116 C462(0.65)  LDD0726  [2]
 LDCM0410  CL22 HCT 116 C462(0.72)  LDD0727  [2]
 LDCM0411  CL23 HCT 116 C462(0.64)  LDD0728  [2]
 LDCM0412  CL24 HCT 116 C462(0.68)  LDD0729  [2]
 LDCM0413  CL25 HCT 116 C462(0.57)  LDD0730  [2]
 LDCM0414  CL26 HCT 116 C462(0.74)  LDD0731  [2]
 LDCM0415  CL27 HCT 116 C462(0.65)  LDD0732  [2]
 LDCM0416  CL28 HCT 116 C462(0.69)  LDD0733  [2]
 LDCM0417  CL29 HCT 116 C462(0.74)  LDD0734  [2]
 LDCM0418  CL3 HCT 116 C462(1.03)  LDD0735  [2]
 LDCM0419  CL30 HCT 116 C462(0.83)  LDD0736  [2]
 LDCM0429  CL4 HCT 116 C462(1.00)  LDD0746  [2]
 LDCM0440  CL5 HCT 116 C462(0.96)  LDD0757  [2]
 LDCM0451  CL6 HCT 116 C462(1.09)  LDD0768  [2]
 LDCM0453  CL61 HCT 116 C462(0.94)  LDD0770  [2]
 LDCM0454  CL62 HCT 116 C462(0.78)  LDD0771  [2]
 LDCM0455  CL63 HCT 116 C462(0.67)  LDD0772  [2]
 LDCM0456  CL64 HCT 116 C462(0.63)  LDD0773  [2]
 LDCM0457  CL65 HCT 116 C462(0.92)  LDD0774  [2]
 LDCM0458  CL66 HCT 116 C462(0.62)  LDD0775  [2]
 LDCM0459  CL67 HCT 116 C462(0.67)  LDD0776  [2]
 LDCM0460  CL68 HCT 116 C462(0.82)  LDD0777  [2]
 LDCM0461  CL69 HCT 116 C462(1.45)  LDD0778  [2]
 LDCM0462  CL7 HCT 116 C462(0.91)  LDD0779  [2]
 LDCM0463  CL70 HCT 116 C462(0.89)  LDD0780  [2]
 LDCM0464  CL71 HCT 116 C462(0.71)  LDD0781  [2]
 LDCM0465  CL72 HCT 116 C462(1.03)  LDD0782  [2]
 LDCM0466  CL73 HCT 116 C462(0.69)  LDD0783  [2]
 LDCM0467  CL74 HCT 116 C462(0.75)  LDD0784  [2]
 LDCM0469  CL76 HCT 116 C462(0.79)  LDD0786  [2]
 LDCM0470  CL77 HCT 116 C462(0.66)  LDD0787  [2]
 LDCM0471  CL78 HCT 116 C462(0.57)  LDD0788  [2]
 LDCM0472  CL79 HCT 116 C462(0.49)  LDD0789  [2]
 LDCM0473  CL8 HCT 116 C462(0.98)  LDD0790  [2]
 LDCM0474  CL80 HCT 116 C462(1.03)  LDD0791  [2]
 LDCM0475  CL81 HCT 116 C462(0.55)  LDD0792  [2]
 LDCM0476  CL82 HCT 116 C462(0.49)  LDD0793  [2]
 LDCM0477  CL83 HCT 116 C462(0.50)  LDD0794  [2]
 LDCM0478  CL84 HCT 116 C462(0.56)  LDD0795  [2]
 LDCM0479  CL85 HCT 116 C462(0.54)  LDD0796  [2]
 LDCM0480  CL86 HCT 116 C462(0.66)  LDD0797  [2]
 LDCM0481  CL87 HCT 116 C462(0.48)  LDD0798  [2]
 LDCM0482  CL88 HCT 116 C462(0.47)  LDD0799  [2]
 LDCM0483  CL89 HCT 116 C462(0.62)  LDD0800  [2]
 LDCM0484  CL9 HCT 116 C462(0.94)  LDD0801  [2]
 LDCM0485  CL90 HCT 116 C462(0.82)  LDD0802  [2]
 LDCM0486  CL91 HCT 116 C462(1.13)  LDD0803  [2]
 LDCM0487  CL92 HCT 116 C462(1.28)  LDD0804  [2]
 LDCM0488  CL93 HCT 116 C462(1.10)  LDD0805  [2]
 LDCM0489  CL94 HCT 116 C462(1.00)  LDD0806  [2]
 LDCM0490  CL95 HCT 116 C462(1.00)  LDD0807  [2]
 LDCM0491  CL96 HCT 116 C462(0.99)  LDD0808  [2]
 LDCM0492  CL97 HCT 116 C462(1.05)  LDD0809  [2]
 LDCM0493  CL98 HCT 116 C462(0.94)  LDD0810  [2]
 LDCM0494  CL99 HCT 116 C462(1.03)  LDD0811  [2]
 LDCM0625  F8 Ramos C249(1.20)  LDD2187  [8]
 LDCM0574  Fragment12 Ramos C249(2.01)  LDD2191  [8]
 LDCM0575  Fragment13 Ramos C249(0.84)  LDD2192  [8]
 LDCM0576  Fragment14 Ramos C249(0.87)  LDD2193  [8]
 LDCM0579  Fragment20 Ramos C249(0.91)  LDD2194  [8]
 LDCM0580  Fragment21 Ramos C249(0.81)  LDD2195  [8]
 LDCM0582  Fragment23 Ramos C249(0.91)  LDD2196  [8]
 LDCM0578  Fragment27 Ramos C249(0.88)  LDD2197  [8]
 LDCM0586  Fragment28 Ramos C249(1.21)  LDD2198  [8]
 LDCM0588  Fragment30 Ramos C249(0.92)  LDD2199  [8]
 LDCM0468  Fragment33 HCT 116 C462(0.85)  LDD0785  [2]
 LDCM0596  Fragment38 Ramos C249(0.66)  LDD2203  [8]
 LDCM0566  Fragment4 Ramos C249(1.24)  LDD2184  [8]
 LDCM0614  Fragment56 Ramos C249(0.87)  LDD2205  [8]
 LDCM0569  Fragment7 Ramos C249(1.20)  LDD2186  [8]
 LDCM0022  KB02 T cell-activated C249(5.54)  LDD1704  [9]
 LDCM0023  KB03 Ramos C249(1.44)  LDD2183  [8]
 LDCM0024  KB05 Ramos C249(1.45)  LDD2185  [8]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Deubiquitinase MYSM1 (MYSM1) Peptidase M67A family Q5VVJ2
Other
Click To Hide/Show 4 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Heat shock factor-binding protein 1 (HSBP1) HSBP1 family O75506
Protein lin-7 homolog A (LIN7A) Lin-7 family O14910
Protein lin-7 homolog B (LIN7B) Lin-7 family Q9HAP6
Protein lin-7 homolog C (LIN7C) Lin-7 family Q9NUP9

References

1 An Azo Coupling-Based Chemoproteomic Approach to Systematically Profile the Tyrosine Reactivity in the Human Proteome. Anal Chem. 2021 Jul 27;93(29):10334-10342. doi: 10.1021/acs.analchem.1c01935. Epub 2021 Jul 12.
2 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
3 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
4 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
5 DFT-Guided Discovery of Ethynyl-Triazolyl-Phosphinates as Modular Electrophiles for Chemoselective Cysteine Bioconjugation and Profiling. Angew Chem Int Ed Engl. 2022 Oct 10;61(41):e202205348. doi: 10.1002/anie.202205348. Epub 2022 Aug 22.
Mass spectrometry data entry: PXD033004
6 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
7 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
8 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578
9 An Activity-Guided Map of Electrophile-Cysteine Interactions in Primary Human T Cells. Cell. 2020 Aug 20;182(4):1009-1026.e29. doi: 10.1016/j.cell.2020.07.001. Epub 2020 Jul 29.