Details of the Target

General Information of Target

Target ID LDTP07073
Target Name Protein phosphatase 1 regulatory subunit 15B (PPP1R15B)
Gene Name PPP1R15B
Gene ID 84919
Synonyms
Protein phosphatase 1 regulatory subunit 15B
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MEPGTGGSRKRLGPRAGFRFWPPFFPRRSQAGSSKFPTPLGPENSGNPTLLSSAQPETRV
SYWTKLLSQLLAPLPGLLQKVLIWSQLFGGMFPTRWLDFAGVYSALRALKGREKPAAPTA
QKSLSSLQLDSSDPSVTSPLDWLEEGIHWQYSPPDLKLELKAKGSALDPAAQAFLLEQQL
WGVELLPSSLQSRLYSNRELGSSPSGPLNIQRIDNFSVVSYLLNPSYLDCFPRLEVSYQN
SDGNSEVVGFQTLTPESSCLREDHCHPQPLSAELIPASWQGCPPLSTEGLPEIHHLRMKR
LEFLQQASKGQDLPTPDQDNGYHSLEEEHSLLRMDPKHCRDNPTQFVPAAGDIPGNTQES
TEEKIELLTTEVPLALEEESPSEGCPSSEIPMEKEPGEGRISVVDYSYLEGDLPISARPA
CSNKLIDYILGGASSDLETSSDPEGEDWDEEAEDDGFDSDSSLSDSDLEQDPEGLHLWNS
FCSVDPYNPQNFTATIQTAARIVPEEPSDSEKDLSGKSDLENSSQSGSLPETPEHSSGEE
DDWESSADEAESLKLWNSFCNSDDPYNPLNFKAPFQTSGENEKGCRDSKTPSESIVAISE
CHTLLSCKVQLLGSQESECPDSVQRDVLSGGRHTHVKRKKVTFLEEVTEYYISGDEDRKG
PWEEFARDGCRFQKRIQETEDAIGYCLTFEHRERMFNRLQGTCFKGLNVLKQC
Target Bioclass
Other
Family
PPP1R15 family
Function Maintains low levels of EIF2S1 phosphorylation in unstressed cells by promoting its dephosphorylation by PP1.
Uniprot ID
Q5SWA1
Ensemble ID
ENST00000367188.5
HGNC ID
HGNC:14951
ChEMBL ID
CHEMBL4630830

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 5 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C703(0.69)  LDD0531  [1]
NAIA_4
 Probe Info  		N.A.  LDD2226  [2]
IPM
 Probe Info  		C703(0.00); C421(0.00)  LDD0147  [3]
TFBX
 Probe Info  		N.A.  LDD0148  [3]
NAIA_5
 Probe Info  		N.A.  LDD2223  [2]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HCT 116 C703(0.69)  LDD0531  [1]
 LDCM0215  AC10 HCT 116 C703(1.21)  LDD0532  [1]
 LDCM0216  AC100 HCT 116 C703(0.93)  LDD0533  [1]
 LDCM0217  AC101 HCT 116 C703(0.99)  LDD0534  [1]
 LDCM0218  AC102 HCT 116 C703(0.92)  LDD0535  [1]
 LDCM0219  AC103 HCT 116 C703(1.17)  LDD0536  [1]
 LDCM0220  AC104 HCT 116 C703(1.08)  LDD0537  [1]
 LDCM0221  AC105 HCT 116 C703(1.06)  LDD0538  [1]
 LDCM0222  AC106 HCT 116 C703(1.10)  LDD0539  [1]
 LDCM0223  AC107 HCT 116 C703(1.18)  LDD0540  [1]
 LDCM0224  AC108 HCT 116 C703(0.88)  LDD0541  [1]
 LDCM0225  AC109 HCT 116 C703(0.94)  LDD0542  [1]
 LDCM0226  AC11 HCT 116 C703(1.25)  LDD0543  [1]
 LDCM0227  AC110 HCT 116 C703(0.83)  LDD0544  [1]
 LDCM0228  AC111 HCT 116 C703(0.96)  LDD0545  [1]
 LDCM0229  AC112 HCT 116 C703(1.15)  LDD0546  [1]
 LDCM0230  AC113 HCT 116 C703(1.08)  LDD0547  [1]
 LDCM0231  AC114 HCT 116 C703(1.31)  LDD0548  [1]
 LDCM0232  AC115 HCT 116 C703(1.34)  LDD0549  [1]
 LDCM0233  AC116 HCT 116 C703(1.31)  LDD0550  [1]
 LDCM0234  AC117 HCT 116 C703(1.30)  LDD0551  [1]
 LDCM0235  AC118 HCT 116 C703(1.00)  LDD0552  [1]
 LDCM0236  AC119 HCT 116 C703(1.07)  LDD0553  [1]
 LDCM0237  AC12 HCT 116 C703(0.99)  LDD0554  [1]
 LDCM0238  AC120 HCT 116 C703(1.15)  LDD0555  [1]
 LDCM0239  AC121 HCT 116 C703(1.14)  LDD0556  [1]
 LDCM0240  AC122 HCT 116 C703(1.05)  LDD0557  [1]
 LDCM0241  AC123 HCT 116 C703(0.85)  LDD0558  [1]
 LDCM0242  AC124 HCT 116 C703(1.13)  LDD0559  [1]
 LDCM0243  AC125 HCT 116 C703(1.07)  LDD0560  [1]
 LDCM0244  AC126 HCT 116 C703(0.98)  LDD0561  [1]
 LDCM0245  AC127 HCT 116 C703(0.91)  LDD0562  [1]
 LDCM0259  AC14 HCT 116 C703(1.28)  LDD0576  [1]
 LDCM0263  AC143 HCT 116 C703(1.17)  LDD0580  [1]
 LDCM0264  AC144 HCT 116 C703(1.02)  LDD0581  [1]
 LDCM0265  AC145 HCT 116 C703(1.23)  LDD0582  [1]
 LDCM0266  AC146 HCT 116 C703(1.00)  LDD0583  [1]
 LDCM0267  AC147 HCT 116 C703(1.00)  LDD0584  [1]
 LDCM0268  AC148 HCT 116 C703(1.29)  LDD0585  [1]
 LDCM0269  AC149 HCT 116 C703(1.13)  LDD0586  [1]
 LDCM0270  AC15 HCT 116 C703(1.15)  LDD0587  [1]
 LDCM0271  AC150 HCT 116 C703(0.90)  LDD0588  [1]
 LDCM0272  AC151 HCT 116 C703(0.82)  LDD0589  [1]
 LDCM0273  AC152 HCT 116 C703(0.91)  LDD0590  [1]
 LDCM0274  AC153 HCT 116 C703(1.32)  LDD0591  [1]
 LDCM0621  AC154 HCT 116 C703(0.95)  LDD2158  [1]
 LDCM0622  AC155 HCT 116 C703(0.92)  LDD2159  [1]
 LDCM0623  AC156 HCT 116 C703(0.81)  LDD2160  [1]
 LDCM0624  AC157 HCT 116 C703(1.09)  LDD2161  [1]
 LDCM0276  AC17 HCT 116 C703(0.98)  LDD0593  [1]
 LDCM0277  AC18 HCT 116 C703(1.74)  LDD0594  [1]
 LDCM0278  AC19 HCT 116 C703(1.24)  LDD0595  [1]
 LDCM0279  AC2 HCT 116 C703(0.86)  LDD0596  [1]
 LDCM0280  AC20 HCT 116 C703(1.07)  LDD0597  [1]
 LDCM0281  AC21 HCT 116 C703(0.96)  LDD0598  [1]
 LDCM0282  AC22 HCT 116 C703(0.87)  LDD0599  [1]
 LDCM0283  AC23 HCT 116 C703(0.99)  LDD0600  [1]
 LDCM0284  AC24 HCT 116 C703(0.91)  LDD0601  [1]
 LDCM0285  AC25 HEK-293T C703(0.93); C560(1.01)  LDD1524  [4]
 LDCM0286  AC26 HEK-293T C560(0.91)  LDD1525  [4]
 LDCM0287  AC27 HEK-293T C703(1.11); C560(1.13)  LDD1526  [4]
 LDCM0288  AC28 HEK-293T C703(0.98)  LDD1527  [4]
 LDCM0289  AC29 HEK-293T C703(1.07); C560(1.16)  LDD1528  [4]
 LDCM0290  AC3 HCT 116 C703(0.95)  LDD0607  [1]
 LDCM0291  AC30 HEK-293T C703(0.98); C560(0.86)  LDD1530  [4]
 LDCM0292  AC31 HEK-293T C703(0.97); C560(0.79)  LDD1531  [4]
 LDCM0293  AC32 HEK-293T C560(1.05)  LDD1532  [4]
 LDCM0294  AC33 HEK-293T C703(0.82); C560(0.80)  LDD1533  [4]
 LDCM0295  AC34 HEK-293T C560(0.85)  LDD1534  [4]
 LDCM0296  AC35 HEK-293T C703(1.04); C560(1.04)  LDD1535  [4]
 LDCM0297  AC36 HEK-293T C703(0.91)  LDD1536  [4]
 LDCM0298  AC37 HEK-293T C703(0.91); C560(0.86)  LDD1537  [4]
 LDCM0299  AC38 HEK-293T C703(0.87); C560(0.79)  LDD1538  [4]
 LDCM0300  AC39 HEK-293T C703(0.91); C560(1.26)  LDD1539  [4]
 LDCM0301  AC4 HCT 116 C703(0.81)  LDD0618  [1]
 LDCM0302  AC40 HEK-293T C560(1.22)  LDD1541  [4]
 LDCM0303  AC41 HEK-293T C703(0.99); C560(0.85)  LDD1542  [4]
 LDCM0304  AC42 HEK-293T C560(0.88)  LDD1543  [4]
 LDCM0305  AC43 HEK-293T C703(1.04); C560(1.27)  LDD1544  [4]
 LDCM0306  AC44 HEK-293T C703(0.94)  LDD1545  [4]
 LDCM0307  AC45 HEK-293T C703(1.14); C560(1.22)  LDD1546  [4]
 LDCM0308  AC46 HCT 116 C703(0.79)  LDD0625  [1]
 LDCM0309  AC47 HCT 116 C703(0.88)  LDD0626  [1]
 LDCM0310  AC48 HCT 116 C703(0.99)  LDD0627  [1]
 LDCM0311  AC49 HCT 116 C703(1.16)  LDD0628  [1]
 LDCM0312  AC5 HCT 116 C703(0.81)  LDD0629  [1]
 LDCM0313  AC50 HCT 116 C703(1.03)  LDD0630  [1]
 LDCM0314  AC51 HCT 116 C703(0.84)  LDD0631  [1]
 LDCM0315  AC52 HCT 116 C703(0.89)  LDD0632  [1]
 LDCM0316  AC53 HCT 116 C703(1.17)  LDD0633  [1]
 LDCM0317  AC54 HCT 116 C703(1.02)  LDD0634  [1]
 LDCM0318  AC55 HCT 116 C703(1.09)  LDD0635  [1]
 LDCM0319  AC56 HCT 116 C703(1.31)  LDD0636  [1]
 LDCM0320  AC57 HEK-293T C703(0.85); C560(1.14)  LDD1559  [4]
 LDCM0321  AC58 HEK-293T C560(0.97)  LDD1560  [4]
 LDCM0322  AC59 HEK-293T C703(0.96); C560(1.66)  LDD1561  [4]
 LDCM0323  AC6 HCT 116 C703(1.16)  LDD0640  [1]
 LDCM0324  AC60 HEK-293T C703(0.92)  LDD1563  [4]
 LDCM0325  AC61 HEK-293T C703(0.97); C560(1.44)  LDD1564  [4]
 LDCM0326  AC62 HEK-293T C703(0.87); C560(0.83)  LDD1565  [4]
 LDCM0327  AC63 HEK-293T C703(0.99); C560(1.03)  LDD1566  [4]
 LDCM0328  AC64 HEK-293T C560(1.17)  LDD1567  [4]
 LDCM0334  AC7 HCT 116 C703(1.25)  LDD0651  [1]
 LDCM0345  AC8 HCT 116 C703(1.09)  LDD0662  [1]
 LDCM0365  AC98 HCT 116 C703(1.37)  LDD0682  [1]
 LDCM0366  AC99 HCT 116 C703(0.94)  LDD0683  [1]
 LDCM0248  AKOS034007472 HCT 116 C703(0.99)  LDD0565  [1]
 LDCM0356  AKOS034007680 HCT 116 C703(1.15)  LDD0673  [1]
 LDCM0275  AKOS034007705 HCT 116 C703(1.33)  LDD0592  [1]
 LDCM0367  CL1 HCT 116 C703(1.13)  LDD0684  [1]
 LDCM0368  CL10 HCT 116 C703(1.04)  LDD0685  [1]
 LDCM0369  CL100 HCT 116 C703(0.81)  LDD0686  [1]
 LDCM0370  CL101 HCT 116 C703(0.95)  LDD0687  [1]
 LDCM0371  CL102 HCT 116 C703(0.90)  LDD0688  [1]
 LDCM0372  CL103 HCT 116 C703(1.09)  LDD0689  [1]
 LDCM0373  CL104 HCT 116 C703(1.18)  LDD0690  [1]
 LDCM0374  CL105 HCT 116 C703(1.14)  LDD0691  [1]
 LDCM0375  CL106 HCT 116 C703(1.43)  LDD0692  [1]
 LDCM0376  CL107 HCT 116 C703(1.57)  LDD0693  [1]
 LDCM0377  CL108 HCT 116 C703(1.41)  LDD0694  [1]
 LDCM0378  CL109 HCT 116 C703(1.09)  LDD0695  [1]
 LDCM0379  CL11 HCT 116 C703(1.85)  LDD0696  [1]
 LDCM0380  CL110 HCT 116 C703(1.30)  LDD0697  [1]
 LDCM0381  CL111 HCT 116 C703(1.48)  LDD0698  [1]
 LDCM0382  CL112 HEK-293T C703(0.89); C560(0.90)  LDD1586  [4]
 LDCM0383  CL113 HEK-293T C703(0.97); C560(1.13)  LDD1587  [4]
 LDCM0384  CL114 HEK-293T C560(0.78)  LDD1588  [4]
 LDCM0385  CL115 HEK-293T C703(1.01); C560(0.97)  LDD1589  [4]
 LDCM0386  CL116 HEK-293T C703(0.83); C560(1.03)  LDD1590  [4]
 LDCM0387  CL117 HEK-293T C703(0.97); C560(1.18)  LDD1591  [4]
 LDCM0388  CL118 HEK-293T C560(0.96)  LDD1592  [4]
 LDCM0389  CL119 HEK-293T C703(1.03); C560(0.92)  LDD1593  [4]
 LDCM0390  CL12 HCT 116 C703(1.11)  LDD0707  [1]
 LDCM0391  CL120 HEK-293T C703(0.91); C560(0.94)  LDD1595  [4]
 LDCM0392  CL121 HCT 116 C703(0.89)  LDD0709  [1]
 LDCM0393  CL122 HCT 116 C703(0.96)  LDD0710  [1]
 LDCM0394  CL123 HCT 116 C703(1.09)  LDD0711  [1]
 LDCM0395  CL124 HCT 116 C703(1.23)  LDD0712  [1]
 LDCM0396  CL125 HEK-293T C703(0.90); C560(1.42)  LDD1600  [4]
 LDCM0397  CL126 HEK-293T C560(1.04)  LDD1601  [4]
 LDCM0398  CL127 HEK-293T C703(1.10); C560(0.96)  LDD1602  [4]
 LDCM0399  CL128 HEK-293T C703(0.90); C560(0.83)  LDD1603  [4]
 LDCM0400  CL13 HCT 116 C703(1.13)  LDD0717  [1]
 LDCM0401  CL14 HCT 116 C703(0.96)  LDD0718  [1]
 LDCM0402  CL15 HCT 116 C703(0.97)  LDD0719  [1]
 LDCM0403  CL16 HEK-293T C703(0.98); C560(1.01)  LDD1607  [4]
 LDCM0404  CL17 HEK-293T C703(0.92); C560(0.96)  LDD1608  [4]
 LDCM0405  CL18 HEK-293T C560(0.88)  LDD1609  [4]
 LDCM0406  CL19 HEK-293T C703(1.11); C560(1.05)  LDD1610  [4]
 LDCM0407  CL2 HCT 116 C703(1.01)  LDD0724  [1]
 LDCM0408  CL20 HEK-293T C703(0.96)  LDD1612  [4]
 LDCM0409  CL21 HEK-293T C703(1.16); C560(0.97)  LDD1613  [4]
 LDCM0410  CL22 HEK-293T C703(0.78); C560(0.75)  LDD1614  [4]
 LDCM0411  CL23 HEK-293T C703(1.00); C560(0.90)  LDD1615  [4]
 LDCM0412  CL24 HEK-293T C560(1.04)  LDD1616  [4]
 LDCM0413  CL25 HEK-293T C703(1.06); C560(1.10)  LDD1617  [4]
 LDCM0414  CL26 HEK-293T C560(1.09)  LDD1618  [4]
 LDCM0415  CL27 HEK-293T C703(1.02); C560(0.98)  LDD1619  [4]
 LDCM0416  CL28 HEK-293T C703(0.89); C560(0.84)  LDD1620  [4]
 LDCM0417  CL29 HEK-293T C703(0.82); C560(0.93)  LDD1621  [4]
 LDCM0418  CL3 HCT 116 C703(0.89)  LDD0735  [1]
 LDCM0419  CL30 HEK-293T C560(0.79)  LDD1623  [4]
 LDCM0420  CL31 HEK-293T C703(1.04); C560(1.08)  LDD1624  [4]
 LDCM0421  CL32 HEK-293T C703(0.99)  LDD1625  [4]
 LDCM0422  CL33 HEK-293T C703(1.59); C560(1.20)  LDD1626  [4]
 LDCM0423  CL34 HEK-293T C703(0.92); C560(0.54)  LDD1627  [4]
 LDCM0424  CL35 HEK-293T C703(1.08); C560(1.04)  LDD1628  [4]
 LDCM0425  CL36 HEK-293T C560(1.03)  LDD1629  [4]
 LDCM0426  CL37 HEK-293T C703(0.95); C560(1.16)  LDD1630  [4]
 LDCM0428  CL39 HEK-293T C703(1.05); C560(0.82)  LDD1632  [4]
 LDCM0429  CL4 HCT 116 C703(0.95)  LDD0746  [1]
 LDCM0430  CL40 HEK-293T C703(0.87); C560(1.02)  LDD1634  [4]
 LDCM0431  CL41 HEK-293T C703(0.90); C560(1.00)  LDD1635  [4]
 LDCM0432  CL42 HEK-293T C560(0.90)  LDD1636  [4]
 LDCM0433  CL43 HEK-293T C703(1.00); C560(0.97)  LDD1637  [4]
 LDCM0434  CL44 HEK-293T C703(0.97)  LDD1638  [4]
 LDCM0435  CL45 HEK-293T C703(1.18); C560(1.13)  LDD1639  [4]
 LDCM0436  CL46 HCT 116 C703(1.23)  LDD0753  [1]
 LDCM0437  CL47 HCT 116 C703(1.22)  LDD0754  [1]
 LDCM0438  CL48 HCT 116 C703(1.16)  LDD0755  [1]
 LDCM0439  CL49 HCT 116 C703(1.04)  LDD0756  [1]
 LDCM0440  CL5 HCT 116 C703(0.83)  LDD0757  [1]
 LDCM0441  CL50 HCT 116 C703(1.18)  LDD0758  [1]
 LDCM0442  CL51 HCT 116 C703(1.34)  LDD0759  [1]
 LDCM0443  CL52 HCT 116 C703(1.30)  LDD0760  [1]
 LDCM0444  CL53 HCT 116 C703(1.16)  LDD0761  [1]
 LDCM0445  CL54 HCT 116 C703(1.28)  LDD0762  [1]
 LDCM0446  CL55 HCT 116 C703(1.01)  LDD0763  [1]
 LDCM0447  CL56 HCT 116 C703(1.13)  LDD0764  [1]
 LDCM0448  CL57 HCT 116 C703(1.21)  LDD0765  [1]
 LDCM0449  CL58 HCT 116 C703(1.07)  LDD0766  [1]
 LDCM0450  CL59 HCT 116 C703(1.13)  LDD0767  [1]
 LDCM0451  CL6 HCT 116 C703(0.93)  LDD0768  [1]
 LDCM0452  CL60 HCT 116 C703(1.28)  LDD0769  [1]
 LDCM0453  CL61 HEK-293T C703(0.87); C560(1.20)  LDD1656  [4]
 LDCM0454  CL62 HEK-293T C560(1.18)  LDD1657  [4]
 LDCM0455  CL63 HEK-293T C703(1.00); C560(1.03)  LDD1658  [4]
 LDCM0456  CL64 HEK-293T C703(1.30); C560(0.51)  LDD1659  [4]
 LDCM0457  CL65 HEK-293T C703(0.84); C560(0.98)  LDD1660  [4]
 LDCM0458  CL66 HEK-293T C560(1.02)  LDD1661  [4]
 LDCM0459  CL67 HEK-293T C703(1.16); C560(1.29)  LDD1662  [4]
 LDCM0460  CL68 HEK-293T C703(1.01)  LDD1663  [4]
 LDCM0461  CL69 HEK-293T C703(0.97); C560(1.07)  LDD1664  [4]
 LDCM0462  CL7 HCT 116 C703(0.92)  LDD0779  [1]
 LDCM0463  CL70 HEK-293T C703(0.88); C560(0.81)  LDD1666  [4]
 LDCM0464  CL71 HEK-293T C703(1.01); C560(0.95)  LDD1667  [4]
 LDCM0465  CL72 HEK-293T C560(1.05)  LDD1668  [4]
 LDCM0466  CL73 HEK-293T C703(0.96); C560(1.04)  LDD1669  [4]
 LDCM0467  CL74 HEK-293T C560(1.16)  LDD1670  [4]
 LDCM0469  CL76 HEK-293T C703(0.95); C560(1.01)  LDD1672  [4]
 LDCM0470  CL77 HEK-293T C703(1.02); C560(0.80)  LDD1673  [4]
 LDCM0471  CL78 HEK-293T C560(0.83)  LDD1674  [4]
 LDCM0472  CL79 HEK-293T C703(1.09); C560(0.84)  LDD1675  [4]
 LDCM0473  CL8 HCT 116 C703(2.63)  LDD0790  [1]
 LDCM0474  CL80 HEK-293T C703(0.87)  LDD1677  [4]
 LDCM0475  CL81 HEK-293T C703(1.04); C560(0.99)  LDD1678  [4]
 LDCM0476  CL82 HEK-293T C703(0.93); C560(0.88)  LDD1679  [4]
 LDCM0477  CL83 HEK-293T C703(1.12); C560(0.75)  LDD1680  [4]
 LDCM0478  CL84 HEK-293T C560(1.13)  LDD1681  [4]
 LDCM0479  CL85 HEK-293T C703(1.02); C560(1.19)  LDD1682  [4]
 LDCM0480  CL86 HEK-293T C560(0.87)  LDD1683  [4]
 LDCM0481  CL87 HEK-293T C703(0.93); C560(1.05)  LDD1684  [4]
 LDCM0482  CL88 HEK-293T C703(0.91); C560(0.96)  LDD1685  [4]
 LDCM0483  CL89 HEK-293T C703(0.87); C560(1.06)  LDD1686  [4]
 LDCM0484  CL9 HCT 116 C703(1.03)  LDD0801  [1]
 LDCM0485  CL90 HEK-293T C560(1.12)  LDD1688  [4]
 LDCM0486  CL91 HCT 116 C703(1.11)  LDD0803  [1]
 LDCM0487  CL92 HCT 116 C703(1.19)  LDD0804  [1]
 LDCM0488  CL93 HCT 116 C703(1.19)  LDD0805  [1]
 LDCM0489  CL94 HCT 116 C703(1.09)  LDD0806  [1]
 LDCM0490  CL95 HCT 116 C703(1.08)  LDD0807  [1]
 LDCM0491  CL96 HCT 116 C703(1.06)  LDD0808  [1]
 LDCM0492  CL97 HCT 116 C703(0.88)  LDD0809  [1]
 LDCM0493  CL98 HCT 116 C703(0.96)  LDD0810  [1]
 LDCM0494  CL99 HCT 116 C703(0.85)  LDD0811  [1]
 LDCM0495  E2913 HEK-293T C703(0.92); C560(0.93)  LDD1698  [4]
 LDCM0468  Fragment33 HEK-293T C703(0.91); C560(0.95)  LDD1671  [4]
 LDCM0427  Fragment51 HEK-293T C560(1.43)  LDD1631  [4]
 LDCM0022  KB02 HEK-293T C619(0.97); C560(0.69); C385(1.03)  LDD1492  [4]
 LDCM0023  KB03 HEK-293T C619(1.00); C560(1.12); C385(1.09)  LDD1497  [4]
 LDCM0024  KB05 TF-1 C703(3.65)  LDD3466  [5]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 3 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Serine/threonine-protein phosphatase PP1-alpha catalytic subunit (PPP1CA) PPP phosphatase family P62136
Serine/threonine-protein phosphatase PP1-gamma catalytic subunit (PPP1CC) PPP phosphatase family P36873
E3 ubiquitin-protein ligase TRIM23 (TRIM23) Arf family P36406

References

1 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
2 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
3 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
4 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
5 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840