Details of the Target

General Information of Target

Target ID LDTP06916
Target Name Single-strand selective monofunctional uracil DNA glycosylase (SMUG1)
Gene Name SMUG1
Gene ID 23583
Synonyms
Single-strand selective monofunctional uracil DNA glycosylase; EC 3.2.2.-
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MPQAFLLGSIHEPAGALMEPQPCPGSLAESFLEEELRLNAELSQLQFSEPVGIIYNPVEY
AWEPHRNYVTRYCQGPKEVLFLGMNPGPFGMAQTGVPFGEVSMVRDWLGIVGPVLTPPQE
HPKRPVLGLECPQSEVSGARFWGFFRNLCGQPEVFFHHCFVHNLCPLLFLAPSGRNLTPA
ELPAKQREQLLGICDAALCRQVQLLGVRLVVGVGRLAEQRARRALAGLMPEVQVEGLLHP
SPRNPQANKGWEAVAKERLNELGLLPLLLK
Target Bioclass
Enzyme
Family
Uracil-DNA glycosylase (UDG) superfamily, SMUG1 family
Subcellular location
Nucleus
Function
Recognizes base lesions in the genome and initiates base excision DNA repair. Acts as a monofunctional DNA glycosylase specific for uracil (U) residues in DNA with a preference for single-stranded DNA substrates. The activity is greater toward mismatches (U/G) compared to matches (U/A). Excises uracil (U), 5-formyluracil (fU) and uracil derivatives bearing an oxidized group at C5 [5-hydroxyuracil (hoU) and 5-hydroxymethyluracil (hmU)] in ssDNA and dsDNA, but not analogous cytosine derivatives (5-hydroxycytosine and 5-formylcytosine), nor other oxidized bases. The activity is damage-specific and salt-dependent. The substrate preference is the following: ssDNA > dsDNA (G pair) = dsDNA (A pair) at low salt concentration, and dsDNA (G pair) > dsDNA (A pair) > ssDNA at high salt concentration.
Uniprot ID
Q53HV7
Ensemble ID
ENST00000243112.9
HGNC ID
HGNC:17148

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
CAL148 Substitution: p.G143V DBIA    Probe Info 
MFE319 SNV: p.A197T DBIA    Probe Info 
NCIH1703 SNV: p.N244S DBIA    Probe Info 
OVK18 SNV: p.L262P .
REH SNV: p.V58M DBIA    Probe Info 
SNU308 SNV: p.L38F DBIA    Probe Info 

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 2 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C73(1.92)  LDD3310  [1]
IPM
 Probe Info  		N.A.  LDD2156  [2]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HEK-293T C131(0.82)  LDD1507  [3]
 LDCM0215  AC10 HEK-293T C199(0.88)  LDD0813  [4]
 LDCM0216  AC100 HEK-293T C131(1.04)  LDD0814  [4]
 LDCM0217  AC101 HEK-293T C131(1.00)  LDD0815  [4]
 LDCM0218  AC102 HEK-293T C131(0.66)  LDD0816  [4]
 LDCM0219  AC103 HEK-293T C131(0.50)  LDD0817  [4]
 LDCM0220  AC104 HEK-293T C131(0.84)  LDD0818  [4]
 LDCM0221  AC105 HEK-293T C131(1.51)  LDD0819  [4]
 LDCM0222  AC106 HEK-293T C131(0.92)  LDD0820  [4]
 LDCM0223  AC107 HEK-293T C131(0.98)  LDD0821  [4]
 LDCM0224  AC108 HEK-293T C131(1.26)  LDD0822  [4]
 LDCM0225  AC109 HEK-293T C131(1.15)  LDD0823  [4]
 LDCM0226  AC11 HEK-293T C199(0.90)  LDD0824  [4]
 LDCM0227  AC110 HEK-293T C131(0.59)  LDD0825  [4]
 LDCM0228  AC111 HEK-293T C131(0.84)  LDD0826  [4]
 LDCM0229  AC112 HEK-293T C131(0.72)  LDD0827  [4]
 LDCM0230  AC113 HEK-293T C194(0.79); C199(0.81)  LDD0828  [4]
 LDCM0231  AC114 HEK-293T C194(0.95); C199(0.91)  LDD0829  [4]
 LDCM0232  AC115 HEK-293T C194(0.78); C199(0.89)  LDD0830  [4]
 LDCM0233  AC116 HEK-293T C194(1.03); C199(0.96)  LDD0831  [4]
 LDCM0234  AC117 HEK-293T C194(0.76); C199(0.80)  LDD0832  [4]
 LDCM0235  AC118 HEK-293T C194(1.08); C199(0.91)  LDD0833  [4]
 LDCM0236  AC119 HEK-293T C194(0.75); C199(0.83)  LDD0834  [4]
 LDCM0237  AC12 HEK-293T C199(0.91)  LDD0835  [4]
 LDCM0238  AC120 HEK-293T C194(1.15); C199(0.98)  LDD0836  [4]
 LDCM0239  AC121 HEK-293T C194(0.75); C199(0.68)  LDD0837  [4]
 LDCM0240  AC122 HEK-293T C194(0.73); C199(0.73)  LDD0838  [4]
 LDCM0241  AC123 HEK-293T C194(0.84); C199(0.76)  LDD0839  [4]
 LDCM0242  AC124 HEK-293T C194(1.05); C199(0.94)  LDD0840  [4]
 LDCM0243  AC125 HEK-293T C194(1.06); C199(0.98)  LDD0841  [4]
 LDCM0244  AC126 HEK-293T C194(0.79); C199(0.86)  LDD0842  [4]
 LDCM0245  AC127 HEK-293T C194(1.15); C199(1.07)  LDD0843  [4]
 LDCM0246  AC128 HEK-293T C194(0.88); C199(0.88)  LDD0844  [4]
 LDCM0247  AC129 HEK-293T C194(0.66); C199(0.66)  LDD0845  [4]
 LDCM0249  AC130 HEK-293T C194(0.74); C199(0.74)  LDD0847  [4]
 LDCM0250  AC131 HEK-293T C194(0.98); C199(0.98)  LDD0848  [4]
 LDCM0251  AC132 HEK-293T C194(0.63); C199(0.63)  LDD0849  [4]
 LDCM0252  AC133 HEK-293T C194(0.78); C199(0.78)  LDD0850  [4]
 LDCM0253  AC134 HEK-293T C194(0.83); C199(0.83)  LDD0851  [4]
 LDCM0254  AC135 HEK-293T C194(1.09); C199(1.09)  LDD0852  [4]
 LDCM0255  AC136 HEK-293T C194(1.07); C199(1.07)  LDD0853  [4]
 LDCM0256  AC137 HEK-293T C194(0.77); C199(0.77)  LDD0854  [4]
 LDCM0257  AC138 HEK-293T C194(0.69); C199(0.69)  LDD0855  [4]
 LDCM0258  AC139 HEK-293T C194(0.71); C199(0.71)  LDD0856  [4]
 LDCM0259  AC14 HEK-293T C199(0.92)  LDD0857  [4]
 LDCM0260  AC140 HEK-293T C194(0.82); C199(0.82)  LDD0858  [4]
 LDCM0261  AC141 HEK-293T C194(0.81); C199(0.81)  LDD0859  [4]
 LDCM0262  AC142 HEK-293T C194(0.69); C199(0.69)  LDD0860  [4]
 LDCM0263  AC143 HEK-293T C131(1.13); C194(0.99); C199(0.88)  LDD0861  [4]
 LDCM0264  AC144 HEK-293T C131(1.05); C194(1.13); C199(0.85)  LDD0862  [4]
 LDCM0265  AC145 HEK-293T C131(1.09); C194(1.13); C199(0.89)  LDD0863  [4]
 LDCM0266  AC146 HEK-293T C131(0.94); C194(1.13); C199(0.92)  LDD0864  [4]
 LDCM0267  AC147 HEK-293T C131(0.84); C194(1.19); C199(0.86)  LDD0865  [4]
 LDCM0268  AC148 HEK-293T C131(0.71); C194(0.88); C199(0.96)  LDD0866  [4]
 LDCM0269  AC149 HEK-293T C131(0.98); C194(0.92); C199(0.94)  LDD0867  [4]
 LDCM0270  AC15 HEK-293T C199(0.73)  LDD0868  [4]
 LDCM0271  AC150 HEK-293T C131(0.69); C194(0.99); C199(0.91)  LDD0869  [4]
 LDCM0272  AC151 HEK-293T C131(0.77); C194(1.05); C199(0.90)  LDD0870  [4]
 LDCM0273  AC152 HEK-293T C131(0.94); C194(0.95); C199(1.16)  LDD0871  [4]
 LDCM0274  AC153 HEK-293T C131(0.83); C194(0.96); C199(0.94)  LDD0872  [4]
 LDCM0621  AC154 HEK-293T C131(0.77); C194(0.98); C199(0.95)  LDD2162  [4]
 LDCM0622  AC155 HEK-293T C131(1.13); C194(0.98); C199(0.99)  LDD2163  [4]
 LDCM0623  AC156 HEK-293T C131(0.94); C194(1.11); C199(1.26)  LDD2164  [4]
 LDCM0624  AC157 HEK-293T C131(0.79); C194(1.32); C199(1.10)  LDD2165  [4]
 LDCM0276  AC17 HEK-293T C199(0.58)  LDD0874  [4]
 LDCM0277  AC18 HEK-293T C199(0.57)  LDD0875  [4]
 LDCM0278  AC19 HEK-293T C199(0.72)  LDD0876  [4]
 LDCM0279  AC2 HEK-293T C131(0.92)  LDD1518  [3]
 LDCM0280  AC20 HEK-293T C199(0.64)  LDD0878  [4]
 LDCM0281  AC21 HEK-293T C199(0.78)  LDD0879  [4]
 LDCM0282  AC22 HEK-293T C199(0.57)  LDD0880  [4]
 LDCM0283  AC23 HEK-293T C199(0.55)  LDD0881  [4]
 LDCM0284  AC24 HEK-293T C199(0.88)  LDD0882  [4]
 LDCM0285  AC25 HEK-293T C131(1.08)  LDD1524  [3]
 LDCM0286  AC26 HEK-293T C131(0.94)  LDD1525  [3]
 LDCM0287  AC27 HEK-293T C131(1.07)  LDD1526  [3]
 LDCM0288  AC28 HEK-293T C131(1.06)  LDD1527  [3]
 LDCM0289  AC29 HEK-293T C131(1.05); C149(1.21); C165(1.21)  LDD1528  [3]
 LDCM0290  AC3 HEK-293T C131(1.00)  LDD1529  [3]
 LDCM0291  AC30 HEK-293T C131(1.04)  LDD1530  [3]
 LDCM0292  AC31 HEK-293T C131(0.93)  LDD1531  [3]
 LDCM0293  AC32 HEK-293T C131(0.95)  LDD1532  [3]
 LDCM0294  AC33 HEK-293T C131(1.13)  LDD1533  [3]
 LDCM0295  AC34 HEK-293T C131(1.02)  LDD1534  [3]
 LDCM0296  AC35 HEK-293T C199(0.86)  LDD0894  [4]
 LDCM0297  AC36 HEK-293T C199(1.08)  LDD0895  [4]
 LDCM0298  AC37 HEK-293T C199(1.07)  LDD0896  [4]
 LDCM0299  AC38 HEK-293T C199(1.00)  LDD0897  [4]
 LDCM0300  AC39 HEK-293T C199(0.81)  LDD0898  [4]
 LDCM0301  AC4 HEK-293T C131(1.00)  LDD1540  [3]
 LDCM0302  AC40 HEK-293T C199(0.92)  LDD0900  [4]
 LDCM0303  AC41 HEK-293T C199(1.15)  LDD0901  [4]
 LDCM0304  AC42 HEK-293T C199(1.12)  LDD0902  [4]
 LDCM0305  AC43 HEK-293T C199(0.96)  LDD0903  [4]
 LDCM0306  AC44 HEK-293T C199(1.01)  LDD0904  [4]
 LDCM0307  AC45 HEK-293T C199(1.20)  LDD0905  [4]
 LDCM0308  AC46 HEK-293T C131(1.07)  LDD1547  [3]
 LDCM0309  AC47 HEK-293T C131(1.07)  LDD1548  [3]
 LDCM0310  AC48 HEK-293T C131(1.11)  LDD1549  [3]
 LDCM0311  AC49 HEK-293T C131(0.99)  LDD1550  [3]
 LDCM0312  AC5 HEK-293T C131(1.02); C149(1.25); C165(1.25)  LDD1551  [3]
 LDCM0313  AC50 HEK-293T C131(1.04)  LDD1552  [3]
 LDCM0314  AC51 HEK-293T C131(1.01)  LDD1553  [3]
 LDCM0315  AC52 HEK-293T C131(1.05)  LDD1554  [3]
 LDCM0316  AC53 HEK-293T C131(1.00); C149(1.35); C165(1.35)  LDD1555  [3]
 LDCM0317  AC54 HEK-293T C131(1.22)  LDD1556  [3]
 LDCM0318  AC55 HEK-293T C131(0.99)  LDD1557  [3]
 LDCM0319  AC56 HEK-293T C131(1.01)  LDD1558  [3]
 LDCM0320  AC57 HEK-293T C131(1.01)  LDD1559  [3]
 LDCM0321  AC58 HEK-293T C131(1.00)  LDD1560  [3]
 LDCM0322  AC59 HEK-293T C131(1.11)  LDD1561  [3]
 LDCM0323  AC6 HEK-293T C199(0.97)  LDD0921  [4]
 LDCM0324  AC60 HEK-293T C131(1.03)  LDD1563  [3]
 LDCM0325  AC61 HEK-293T C131(1.19); C149(1.19); C165(1.19)  LDD1564  [3]
 LDCM0326  AC62 HEK-293T C131(1.01)  LDD1565  [3]
 LDCM0327  AC63 HEK-293T C131(1.08)  LDD1566  [3]
 LDCM0328  AC64 HEK-293T C131(1.11)  LDD1567  [3]
 LDCM0332  AC68 HEK-293T C131(1.01)  LDD0930  [4]
 LDCM0333  AC69 HEK-293T C131(1.02)  LDD0931  [4]
 LDCM0334  AC7 HEK-293T C199(0.93)  LDD0932  [4]
 LDCM0335  AC70 HEK-293T C131(0.90)  LDD0933  [4]
 LDCM0336  AC71 HEK-293T C131(0.99)  LDD0934  [4]
 LDCM0337  AC72 HEK-293T C131(0.83)  LDD0935  [4]
 LDCM0338  AC73 HEK-293T C131(0.95)  LDD0936  [4]
 LDCM0339  AC74 HEK-293T C131(0.83)  LDD0937  [4]
 LDCM0340  AC75 HEK-293T C131(1.02)  LDD0938  [4]
 LDCM0341  AC76 HEK-293T C131(0.85)  LDD0939  [4]
 LDCM0342  AC77 HEK-293T C131(1.13)  LDD0940  [4]
 LDCM0343  AC78 HEK-293T C131(0.98)  LDD0941  [4]
 LDCM0344  AC79 HEK-293T C131(0.80)  LDD0942  [4]
 LDCM0345  AC8 HEK-293T C199(0.81)  LDD0943  [4]
 LDCM0346  AC80 HEK-293T C131(0.90)  LDD0944  [4]
 LDCM0347  AC81 HEK-293T C131(1.15)  LDD0945  [4]
 LDCM0348  AC82 HEK-293T C131(0.87)  LDD0946  [4]
 LDCM0365  AC98 HEK-293T C131(0.65)  LDD0963  [4]
 LDCM0366  AC99 HEK-293T C131(1.00)  LDD0964  [4]
 LDCM0248  AKOS034007472 HEK-293T C199(1.29)  LDD0846  [4]
 LDCM0356  AKOS034007680 HEK-293T C199(1.10)  LDD0954  [4]
 LDCM0275  AKOS034007705 HEK-293T C199(0.96)  LDD0873  [4]
 LDCM0367  CL1 HEK-293T C194(0.94); C199(0.94)  LDD0965  [4]
 LDCM0368  CL10 HEK-293T C194(1.17); C199(1.17)  LDD0966  [4]
 LDCM0369  CL100 HEK-293T C131(0.88); C165(0.98)  LDD1573  [3]
 LDCM0370  CL101 HEK-293T C199(0.85)  LDD0968  [4]
 LDCM0371  CL102 HEK-293T C199(0.85)  LDD0969  [4]
 LDCM0372  CL103 HEK-293T C199(0.95)  LDD0970  [4]
 LDCM0373  CL104 HEK-293T C199(0.78)  LDD0971  [4]
 LDCM0374  CL105 HEK-293T C199(0.95)  LDD0972  [4]
 LDCM0375  CL106 HEK-293T C199(0.82)  LDD0973  [4]
 LDCM0376  CL107 HEK-293T C199(0.88)  LDD0974  [4]
 LDCM0377  CL108 HEK-293T C199(0.84)  LDD0975  [4]
 LDCM0378  CL109 HEK-293T C199(0.79)  LDD0976  [4]
 LDCM0379  CL11 HEK-293T C194(0.97); C199(0.97)  LDD0977  [4]
 LDCM0380  CL110 HEK-293T C199(0.73)  LDD0978  [4]
 LDCM0381  CL111 HEK-293T C199(0.82)  LDD0979  [4]
 LDCM0382  CL112 HEK-293T C131(1.06); C165(0.95)  LDD1586  [3]
 LDCM0383  CL113 HEK-293T C131(1.11); C149(1.01); C165(1.01)  LDD1587  [3]
 LDCM0384  CL114 HEK-293T C131(1.00)  LDD1588  [3]
 LDCM0385  CL115 HEK-293T C131(1.03)  LDD1589  [3]
 LDCM0386  CL116 HEK-293T C131(1.18); C165(0.90)  LDD1590  [3]
 LDCM0387  CL117 HEK-293T C199(1.04)  LDD0985  [4]
 LDCM0388  CL118 HEK-293T C199(1.07)  LDD0986  [4]
 LDCM0389  CL119 HEK-293T C199(0.78)  LDD0987  [4]
 LDCM0390  CL12 HEK-293T C194(0.82); C199(0.82)  LDD0988  [4]
 LDCM0391  CL120 HEK-293T C199(0.84)  LDD0989  [4]
 LDCM0392  CL121 HEK-293T C131(0.98); C149(1.16); C165(1.16)  LDD1596  [3]
 LDCM0393  CL122 HEK-293T C131(1.07)  LDD1597  [3]
 LDCM0394  CL123 HEK-293T C131(1.00)  LDD1598  [3]
 LDCM0395  CL124 HEK-293T C131(1.19); C165(1.16)  LDD1599  [3]
 LDCM0396  CL125 HEK-293T C131(1.16); C149(1.28); C165(1.28)  LDD1600  [3]
 LDCM0397  CL126 HEK-293T C131(1.11)  LDD1601  [3]
 LDCM0398  CL127 HEK-293T C131(1.01)  LDD1602  [3]
 LDCM0399  CL128 HEK-293T C131(1.06); C165(1.09)  LDD1603  [3]
 LDCM0400  CL13 HEK-293T C194(1.28); C199(1.28)  LDD0998  [4]
 LDCM0401  CL14 HEK-293T C194(1.07); C199(1.07)  LDD0999  [4]
 LDCM0402  CL15 HEK-293T C194(1.00); C199(1.00)  LDD1000  [4]
 LDCM0403  CL16 HEK-293T C194(0.94); C199(0.94)  LDD1001  [4]
 LDCM0404  CL17 HEK-293T C194(0.82); C199(0.82)  LDD1002  [4]
 LDCM0405  CL18 HEK-293T C194(0.97); C199(0.97)  LDD1003  [4]
 LDCM0406  CL19 HEK-293T C194(0.89); C199(0.89)  LDD1004  [4]
 LDCM0407  CL2 HEK-293T C194(0.88); C199(0.88)  LDD1005  [4]
 LDCM0408  CL20 HEK-293T C194(0.87); C199(0.87)  LDD1006  [4]
 LDCM0409  CL21 HEK-293T C194(0.90); C199(0.90)  LDD1007  [4]
 LDCM0410  CL22 HEK-293T C194(0.92); C199(0.92)  LDD1008  [4]
 LDCM0411  CL23 HEK-293T C194(1.02); C199(1.02)  LDD1009  [4]
 LDCM0412  CL24 HEK-293T C194(0.98); C199(0.98)  LDD1010  [4]
 LDCM0413  CL25 HEK-293T C194(0.84); C199(0.84)  LDD1011  [4]
 LDCM0414  CL26 HEK-293T C194(0.83); C199(0.83)  LDD1012  [4]
 LDCM0415  CL27 HEK-293T C194(0.97); C199(0.97)  LDD1013  [4]
 LDCM0416  CL28 HEK-293T C194(1.16); C199(1.16)  LDD1014  [4]
 LDCM0417  CL29 HEK-293T C194(0.91); C199(0.91)  LDD1015  [4]
 LDCM0418  CL3 HEK-293T C194(0.74); C199(0.74)  LDD1016  [4]
 LDCM0419  CL30 HEK-293T C194(0.95); C199(0.95)  LDD1017  [4]
 LDCM0420  CL31 HEK-293T C131(1.09)  LDD1624  [3]
 LDCM0421  CL32 HEK-293T C131(1.07)  LDD1625  [3]
 LDCM0422  CL33 HEK-293T C131(1.07); C149(1.41); C165(1.41)  LDD1626  [3]
 LDCM0423  CL34 HEK-293T C131(1.07)  LDD1627  [3]
 LDCM0424  CL35 HEK-293T C131(1.07)  LDD1628  [3]
 LDCM0425  CL36 HEK-293T C131(0.98)  LDD1629  [3]
 LDCM0426  CL37 HEK-293T C131(0.84); C149(1.02); C165(1.02)  LDD1630  [3]
 LDCM0428  CL39 HEK-293T C131(0.94)  LDD1632  [3]
 LDCM0429  CL4 HEK-293T C194(1.08); C199(1.08)  LDD1027  [4]
 LDCM0430  CL40 HEK-293T C131(1.12); C165(0.96)  LDD1634  [3]
 LDCM0431  CL41 HEK-293T C131(1.00)  LDD1635  [3]
 LDCM0432  CL42 HEK-293T C131(0.91)  LDD1636  [3]
 LDCM0433  CL43 HEK-293T C131(1.11)  LDD1637  [3]
 LDCM0434  CL44 HEK-293T C131(1.04)  LDD1638  [3]
 LDCM0435  CL45 HEK-293T C131(1.01); C149(1.05); C165(1.05)  LDD1639  [3]
 LDCM0436  CL46 HEK-293T C131(0.85); C199(0.93)  LDD1034  [4]
 LDCM0437  CL47 HEK-293T C131(0.92); C199(0.61)  LDD1035  [4]
 LDCM0438  CL48 HEK-293T C131(1.02); C199(0.57)  LDD1036  [4]
 LDCM0439  CL49 HEK-293T C131(0.72); C199(0.74)  LDD1037  [4]
 LDCM0440  CL5 HEK-293T C194(0.93); C199(0.93)  LDD1038  [4]
 LDCM0441  CL50 HEK-293T C131(0.50); C199(0.69)  LDD1039  [4]
 LDCM0442  CL51 HEK-293T C131(0.53); C199(1.12)  LDD1040  [4]
 LDCM0443  CL52 HEK-293T C131(0.77); C199(1.23)  LDD1041  [4]
 LDCM0444  CL53 HEK-293T C131(0.73); C199(0.59)  LDD1042  [4]
 LDCM0445  CL54 HEK-293T C131(0.68); C199(0.59)  LDD1043  [4]
 LDCM0446  CL55 HEK-293T C131(0.88); C199(0.63)  LDD1044  [4]
 LDCM0447  CL56 HEK-293T C131(0.78); C199(0.55)  LDD1045  [4]
 LDCM0448  CL57 HEK-293T C131(0.82); C199(0.78)  LDD1046  [4]
 LDCM0449  CL58 HEK-293T C131(0.99); C199(0.71)  LDD1047  [4]
 LDCM0450  CL59 HEK-293T C131(0.69); C199(0.68)  LDD1048  [4]
 LDCM0451  CL6 HEK-293T C194(0.86); C199(0.86)  LDD1049  [4]
 LDCM0452  CL60 HEK-293T C131(0.76); C199(0.97)  LDD1050  [4]
 LDCM0453  CL61 HEK-293T C131(1.03); C149(1.09); C165(1.09)  LDD1656  [3]
 LDCM0454  CL62 HEK-293T C131(1.07)  LDD1657  [3]
 LDCM0455  CL63 HEK-293T C131(0.87)  LDD1658  [3]
 LDCM0456  CL64 HEK-293T C131(1.16); C165(1.01)  LDD1659  [3]
 LDCM0457  CL65 HEK-293T C131(0.93)  LDD1660  [3]
 LDCM0458  CL66 HEK-293T C131(0.93)  LDD1661  [3]
 LDCM0459  CL67 HEK-293T C131(1.06)  LDD1662  [3]
 LDCM0460  CL68 HEK-293T C131(1.09)  LDD1663  [3]
 LDCM0461  CL69 HEK-293T C131(1.03); C149(1.28); C165(1.28)  LDD1664  [3]
 LDCM0462  CL7 HEK-293T C194(1.10); C199(1.10)  LDD1060  [4]
 LDCM0463  CL70 HEK-293T C131(1.16)  LDD1666  [3]
 LDCM0464  CL71 HEK-293T C131(1.13)  LDD1667  [3]
 LDCM0465  CL72 HEK-293T C131(1.17)  LDD1668  [3]
 LDCM0466  CL73 HEK-293T C131(0.93); C149(0.91); C165(0.91)  LDD1669  [3]
 LDCM0467  CL74 HEK-293T C131(0.94)  LDD1670  [3]
 LDCM0469  CL76 HEK-293T C194(0.88); C199(0.86)  LDD1067  [4]
 LDCM0470  CL77 HEK-293T C194(0.66); C199(0.83)  LDD1068  [4]
 LDCM0471  CL78 HEK-293T C194(0.80); C199(0.79)  LDD1069  [4]
 LDCM0472  CL79 HEK-293T C194(0.98); C199(0.95)  LDD1070  [4]
 LDCM0473  CL8 HEK-293T C194(0.99); C199(0.66)  LDD1071  [4]
 LDCM0474  CL80 HEK-293T C194(0.85); C199(0.86)  LDD1072  [4]
 LDCM0475  CL81 HEK-293T C194(0.75); C199(0.85)  LDD1073  [4]
 LDCM0476  CL82 HEK-293T C194(0.90); C199(1.11)  LDD1074  [4]
 LDCM0477  CL83 HEK-293T C194(1.07); C199(1.20)  LDD1075  [4]
 LDCM0478  CL84 HEK-293T C194(0.78); C199(0.75)  LDD1076  [4]
 LDCM0479  CL85 HEK-293T C194(0.85); C199(0.86)  LDD1077  [4]
 LDCM0480  CL86 HEK-293T C194(0.94); C199(0.82)  LDD1078  [4]
 LDCM0481  CL87 HEK-293T C194(0.85); C199(0.97)  LDD1079  [4]
 LDCM0482  CL88 HEK-293T C194(0.96); C199(0.96)  LDD1080  [4]
 LDCM0483  CL89 HEK-293T C194(0.90); C199(0.91)  LDD1081  [4]
 LDCM0484  CL9 HEK-293T C194(0.92); C199(0.90)  LDD1082  [4]
 LDCM0485  CL90 HEK-293T C194(0.87); C199(1.00)  LDD1083  [4]
 LDCM0486  CL91 HEK-293T C131(1.05)  LDD1689  [3]
 LDCM0487  CL92 HEK-293T C131(1.09)  LDD1690  [3]
 LDCM0488  CL93 HEK-293T C131(1.19); C149(1.65); C165(1.65)  LDD1691  [3]
 LDCM0489  CL94 HEK-293T C131(1.17)  LDD1692  [3]
 LDCM0490  CL95 HEK-293T C131(0.97)  LDD1693  [3]
 LDCM0491  CL96 HEK-293T C131(1.02)  LDD1694  [3]
 LDCM0492  CL97 HEK-293T C131(0.96); C149(0.91); C165(0.91)  LDD1695  [3]
 LDCM0493  CL98 HEK-293T C131(0.87)  LDD1696  [3]
 LDCM0494  CL99 HEK-293T C131(0.79)  LDD1697  [3]
 LDCM0495  E2913 HEK-293T C131(1.00)  LDD1698  [3]
 LDCM0468  Fragment33 HEK-293T C131(0.89)  LDD1671  [3]
 LDCM0427  Fragment51 HEK-293T C131(1.07)  LDD1631  [3]
 LDCM0022  KB02 HEK-293T C131(1.07)  LDD1492  [3]
 LDCM0023  KB03 HEK-293T C131(1.04)  LDD1497  [3]
 LDCM0024  KB05 COLO792 C73(1.92)  LDD3310  [1]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 3 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
5'-AMP-activated protein kinase subunit beta-2 (PRKAB2) 5'-AMP-activated protein kinase beta subunit family O43741
Cell division cycle protein 23 homolog (CDC23) APC8/CDC23 family Q9UJX2
Glycerate kinase (GLYCTK) Glycerate kinase type-2 family Q8IVS8
Transporter and channel
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Optineurin (OPTN) . Q96CV9
Transcription factor
Click To Hide/Show 5 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Zinc finger protein ZIC 1 (ZIC1) GLI C2H2-type zinc-finger protein family Q15915
Cone-rod homeobox protein (CRX) Paired homeobox family O43186
Homeobox protein prophet of Pit-1 (PROP1) Paired homeobox family O75360
Homeobox protein VENTX (VENTX) . O95231
Pogo transposable element with ZNF domain (POGZ) . Q7Z3K3
Other
Click To Hide/Show 23 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Cysteine-rich tail protein 1 (CYSRT1) CYSRT1 family A8MQ03
Protein FAM222B (FAM222B) FAM222 family Q8WU58
Protein INCA1 (INCA1) INCA family Q0VD86
Keratin-associated protein 6-2 (KRTAP6-2) KRTAP type 6 family Q3LI66
Keratin-associated protein 8-1 (KRTAP8-1) KRTAP type 8 family Q8IUC2
Keratin-associated protein 13-2 (KRTAP13-2) PMG family Q52LG2
Keratin-associated protein 15-1 (KRTAP15-1) PMG family Q3LI76
Keratin-associated protein 26-1 (KRTAP26-1) PMG family Q6PEX3
Ski-like protein (SKIL) SKI family P12757
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 1 (SMARCD1) SMARCD family Q96GM5
Tektin-5 (TEKT5) Tektin family Q96M29
Protein VAC14 homolog (VAC14) VAC14 family Q08AM6
BTB/POZ domain-containing protein KCTD9 (KCTD9) . Q7L273
G protein pathway suppressor 2 (GPS2) . Q13227
Heterogeneous nuclear ribonucleoprotein F (HNRNPF) . P52597
Kelch domain-containing protein 7B (KLHDC7B) . Q96G42
Leucine-rich repeat-containing protein 41 (LRRC41) . Q15345
Peflin (PEF1) . Q9UBV8
Proline-rich protein 13 (PRR13) . Q9NZ81
Proline-rich protein 35 (PRR35) . P0CG20
Protein TFG (TFG) . Q92734
RNA-binding protein with multiple splicing (RBPMS) . Q93062
Uncharacterized protein C10orf55 (C10orf55) . Q5SWW7

References

1 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
2 Benchmarking Cleavable Biotin Tags for Peptide-Centric Chemoproteomics. J Proteome Res. 2022 May 6;21(5):1349-1358. doi: 10.1021/acs.jproteome.2c00174. Epub 2022 Apr 25.
Mass spectrometry data entry: PXD031019
3 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
4 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.