Details of the Target

General Information of Target

Target ID LDTP06838
Target Name La-related protein 7 (LARP7)
Gene Name LARP7
Gene ID 51574
Synonyms
La-related protein 7; La ribonucleoprotein domain family member 7; hLARP7; P-TEFb-interaction protein for 7SK stability; PIP7S
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
METESGNQEKVMEEESTEKKKEVEKKKRSRVKQVLADIAKQVDFWFGDANLHKDRFLREQ
IEKSRDGYVDISLLVSFNKMKKLTTDGKLIARALRSSAVVELDLEGTRIRRKKPLGERPK
DEDERTVYVELLPKNVNHSWIERVFGKCGNVVYISIPHYKSTGDPKGFAFVEFETKEQAA
KAIEFLNNPPEEAPRKPGIFPKTVKNKPIPALRVVEEKKKKKKKKGRMKKEDNIQAKEEN
MDTSNTSISKMKRSRPTSEGSDIESTEPQKQCSKKKKKRDRVEASSLPEVRTGKRKRSSS
EDAESLAPRSKVKKIIQKDIIKEASEASKENRDIEISTEEEKDTGDLKDSSLLKTKRKHK
KKHKERHKMGEEVIPLRVLSKSEWMDLKKEYLALQKASMASLKKTISQIKSESEMETDSG
VPQNTGMKNEKTANREECRTQEKVNATGPQFVSGVIVKIISTEPLPGRKQVRDTLAAISE
VLYVDLLEGDTECHARFKTPEDAQAVINAYTEINKKHCWKLEILSGDHEQRYWQKILVDR
QAKLNQPREKKRGTEKLITKAEKIRLAKTQQASKHIRFSEYD
Target Bioclass
Other
Family
LARP7 family
Subcellular location
Nucleus, nucleoplasm
Function
RNA-binding protein that specifically binds distinct small nuclear RNA (snRNAs) and regulates their processing and function. Specifically binds the 7SK snRNA (7SK RNA) and acts as a core component of the 7SK ribonucleoprotein (RNP) complex, thereby acting as a negative regulator of transcription elongation by RNA polymerase II. The 7SK RNP complex sequesters the positive transcription elongation factor b (P-TEFb) in a large inactive 7SK RNP complex preventing RNA polymerase II phosphorylation and subsequent transcriptional elongation. The 7SK RNP complex also promotes snRNA gene transcription by RNA polymerase II via interaction with the little elongation complex (LEC). LARP7 specifically binds to the highly conserved 3'-terminal U-rich stretch of 7SK RNA; on stimulation, remains associated with 7SK RNA, whereas P-TEFb is released from the complex. LARP7 also acts as a regulator of mRNA splicing fidelity by promoting U6 snRNA processing. Specifically binds U6 snRNAs and associates with a subset of box C/D RNP complexes: promotes U6 snRNA 2'-O-methylation by facilitating U6 snRNA loading into box C/D RNP complexes. U6 snRNA 2'-O-methylation is required for mRNA splicing fidelity. Binds U6 snRNAs with a 5'-CAGGG-3' sequence motif. U6 snRNA processing is required for spermatogenesis.
Uniprot ID
Q4G0J3
Ensemble ID
ENST00000344442.10
HGNC ID
HGNC:24912
ChEMBL ID
CHEMBL4523314

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
CAMA1 SNV: p.S579C .
DU145 SNV: p.G420V .
FTC133 SNV: p.T344I DBIA    Probe Info 
HCT15 SNV: p.R439H .
HEC1 Deletion: p.K26RfsTer36 DBIA    Probe Info 
HEC1B Deletion: p.K26RfsTer36 IA-alkyne    Probe Info 
KP4 SNV: p.I71T .
OVK18 SNV: p.H528R DBIA    Probe Info 

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 20 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		15.00  LDD0402  [1]
ONAyne
 Probe Info  		K318(0.30)  LDD0274  [2]
STPyne
 Probe Info  		K196(10.00); K568(10.00)  LDD0277  [2]
AZ-9
 Probe Info  		E463(10.00)  LDD2209  [3]
DBIA
 Probe Info  		C155(2.07)  LDD3312  [4]
AHL-Pu-1
 Probe Info  		C438(2.61)  LDD0168  [5]
ATP probe
 Probe Info  		K32(0.00); K166(0.00)  LDD0199  [6]
4-Iodoacetamidophenylacetylene
 Probe Info  		C148(0.00); C493(0.00); C438(0.00)  LDD0038  [7]
IA-alkyne
 Probe Info  		C148(0.00); C438(0.00)  LDD0036  [7]
Lodoacetamide azide
 Probe Info  		C493(0.00); C148(0.00); C438(0.00)  LDD0037  [7]
BTD
 Probe Info  		N.A.  LDD0004  [8]
IPM
 Probe Info  		N.A.  LDD0025  [9]
TFBX
 Probe Info  		N.A.  LDD0027  [9]
Phosphinate-6
 Probe Info  		C272(0.00); C438(0.00)  LDD0018  [10]
1d-yne
 Probe Info  		K176(0.00); K443(0.00)  LDD0357  [11]
Crotonaldehyde
 Probe Info  		N.A.  LDD0219  [12]
Methacrolein
 Probe Info  		N.A.  LDD0218  [12]
W1
 Probe Info  		N.A.  LDD0236  [13]
AOyne
 Probe Info  		15.00  LDD0443  [14]
NAIA_5
 Probe Info  		C148(0.00); C493(0.00); C272(0.00)  LDD2223  [15]
PAL-AfBPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
VE-P
 Probe Info  		N.A.  LDD0396  [16]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0548  1-(4-(Benzo[d][1,3]dioxol-5-ylmethyl)piperazin-1-yl)-2-nitroethan-1-one MDA-MB-231 C272(0.64)  LDD2142  [17]
 LDCM0519  1-(6-methoxy-3,4-dihydroquinolin-1(2H)-yl)-2-nitroethan-1-one MDA-MB-231 C272(0.95)  LDD2112  [17]
 LDCM0524  2-Cyano-N-(2-morpholin-4-yl-ethyl)-acetamide MDA-MB-231 C438(1.07)  LDD2117  [17]
 LDCM0025  4SU-RNA HEK-293T C438(2.61)  LDD0168  [5]
 LDCM0026  4SU-RNA+native RNA HEK-293T C438(2.89)  LDD0169  [5]
 LDCM0214  AC1 HEK-293T C438(1.31); C148(1.07)  LDD1507  [18]
 LDCM0215  AC10 HEK-293T C438(1.07); C148(1.14)  LDD1508  [18]
 LDCM0226  AC11 HEK-293T C438(0.93); C148(1.02)  LDD1509  [18]
 LDCM0237  AC12 HEK-293T C438(0.98); C148(1.03)  LDD1510  [18]
 LDCM0259  AC14 HEK-293T C438(0.74); C148(1.12); C493(0.98)  LDD1512  [18]
 LDCM0270  AC15 HEK-293T C438(0.85); C148(1.12)  LDD1513  [18]
 LDCM0276  AC17 HEK-293T C438(0.97); C148(1.09)  LDD1515  [18]
 LDCM0277  AC18 HEK-293T C438(1.20); C148(1.06)  LDD1516  [18]
 LDCM0278  AC19 HEK-293T C438(0.96); C148(1.08)  LDD1517  [18]
 LDCM0279  AC2 HEK-293T C438(1.30); C148(1.08)  LDD1518  [18]
 LDCM0280  AC20 HEK-293T C438(0.97); C148(1.19)  LDD1519  [18]
 LDCM0281  AC21 HEK-293T C438(0.90); C148(1.13)  LDD1520  [18]
 LDCM0282  AC22 HEK-293T C438(0.88); C148(1.04); C493(1.08)  LDD1521  [18]
 LDCM0283  AC23 HEK-293T C438(0.90); C148(1.13)  LDD1522  [18]
 LDCM0284  AC24 HEK-293T C438(0.96); C148(0.98)  LDD1523  [18]
 LDCM0285  AC25 HEK-293T C438(1.05); C148(1.05)  LDD1524  [18]
 LDCM0286  AC26 HEK-293T C438(1.06); C148(1.08)  LDD1525  [18]
 LDCM0287  AC27 HEK-293T C438(0.93); C148(1.10)  LDD1526  [18]
 LDCM0288  AC28 HEK-293T C438(1.10); C148(1.09)  LDD1527  [18]
 LDCM0289  AC29 HEK-293T C438(0.88); C148(1.11)  LDD1528  [18]
 LDCM0290  AC3 HEK-293T C438(1.23); C148(1.05)  LDD1529  [18]
 LDCM0291  AC30 HEK-293T C438(1.03); C148(1.06); C493(0.89)  LDD1530  [18]
 LDCM0292  AC31 HEK-293T C438(0.88); C148(1.13)  LDD1531  [18]
 LDCM0293  AC32 HEK-293T C438(1.07); C148(1.10)  LDD1532  [18]
 LDCM0294  AC33 HEK-293T C438(1.14); C148(1.03)  LDD1533  [18]
 LDCM0295  AC34 HEK-293T C438(1.07); C148(1.12)  LDD1534  [18]
 LDCM0296  AC35 HEK-293T C438(0.92); C148(1.16)  LDD1535  [18]
 LDCM0297  AC36 HEK-293T C438(1.08); C148(1.04)  LDD1536  [18]
 LDCM0298  AC37 HEK-293T C438(0.99); C148(1.14)  LDD1537  [18]
 LDCM0299  AC38 HEK-293T C438(0.84); C148(1.10); C493(1.06)  LDD1538  [18]
 LDCM0300  AC39 HEK-293T C438(0.90); C148(1.10)  LDD1539  [18]
 LDCM0301  AC4 HEK-293T C438(1.46); C148(1.04)  LDD1540  [18]
 LDCM0302  AC40 HEK-293T C438(0.98); C148(1.16)  LDD1541  [18]
 LDCM0303  AC41 HEK-293T C438(1.12); C148(0.99)  LDD1542  [18]
 LDCM0304  AC42 HEK-293T C438(1.18); C148(1.11)  LDD1543  [18]
 LDCM0305  AC43 HEK-293T C438(0.94); C148(1.19)  LDD1544  [18]
 LDCM0306  AC44 HEK-293T C438(1.08); C148(1.16)  LDD1545  [18]
 LDCM0307  AC45 HEK-293T C438(1.00); C148(1.09)  LDD1546  [18]
 LDCM0308  AC46 HEK-293T C438(0.98); C148(1.10); C493(1.07)  LDD1547  [18]
 LDCM0309  AC47 HEK-293T C438(1.01); C148(1.12)  LDD1548  [18]
 LDCM0310  AC48 HEK-293T C438(1.10); C148(1.05)  LDD1549  [18]
 LDCM0311  AC49 HEK-293T C438(1.25); C148(1.15)  LDD1550  [18]
 LDCM0312  AC5 HEK-293T C438(1.17); C148(1.07)  LDD1551  [18]
 LDCM0313  AC50 HEK-293T C438(1.33); C148(1.21)  LDD1552  [18]
 LDCM0314  AC51 HEK-293T C438(1.04); C148(1.08)  LDD1553  [18]
 LDCM0315  AC52 HEK-293T C438(1.01); C148(1.08)  LDD1554  [18]
 LDCM0316  AC53 HEK-293T C438(1.07); C148(1.13)  LDD1555  [18]
 LDCM0317  AC54 HEK-293T C438(0.92); C148(1.13); C493(1.09)  LDD1556  [18]
 LDCM0318  AC55 HEK-293T C438(0.99); C148(1.16)  LDD1557  [18]
 LDCM0319  AC56 HEK-293T C438(1.01); C148(1.11)  LDD1558  [18]
 LDCM0320  AC57 HEK-293T C438(1.17); C148(1.02)  LDD1559  [18]
 LDCM0321  AC58 HEK-293T C438(1.27); C148(1.03)  LDD1560  [18]
 LDCM0322  AC59 HEK-293T C438(1.15); C148(1.10)  LDD1561  [18]
 LDCM0323  AC6 HEK-293T C438(1.25); C148(1.01); C493(1.00)  LDD1562  [18]
 LDCM0324  AC60 HEK-293T C438(1.15); C148(1.04)  LDD1563  [18]
 LDCM0325  AC61 HEK-293T C438(1.22); C148(0.97)  LDD1564  [18]
 LDCM0326  AC62 HEK-293T C438(1.21); C148(1.07); C493(0.98)  LDD1565  [18]
 LDCM0327  AC63 HEK-293T C438(0.97); C148(1.02)  LDD1566  [18]
 LDCM0328  AC64 HEK-293T C438(1.52); C148(1.08)  LDD1567  [18]
 LDCM0334  AC7 HEK-293T C438(1.10); C148(1.10)  LDD1568  [18]
 LDCM0345  AC8 HEK-293T C438(1.11); C148(1.01)  LDD1569  [18]
 LDCM0248  AKOS034007472 HEK-293T C438(1.00); C148(1.10)  LDD1511  [18]
 LDCM0356  AKOS034007680 HEK-293T C438(1.05); C148(1.07)  LDD1570  [18]
 LDCM0275  AKOS034007705 HEK-293T C438(0.91); C148(1.10)  LDD1514  [18]
 LDCM0498  BS-3668 MDA-MB-231 C272(0.39)  LDD2091  [17]
 LDCM0632  CL-Sc Hep-G2 C272(20.00); C272(0.80)  LDD2227  [15]
 LDCM0367  CL1 HEK-293T C438(0.92); C148(0.98)  LDD1571  [18]
 LDCM0368  CL10 HEK-293T C438(0.34); C148(0.77); C493(0.75)  LDD1572  [18]
 LDCM0369  CL100 HEK-293T C438(1.17); C148(1.10)  LDD1573  [18]
 LDCM0370  CL101 HEK-293T C438(1.04); C148(1.08)  LDD1574  [18]
 LDCM0371  CL102 HEK-293T C438(0.95); C148(1.11)  LDD1575  [18]
 LDCM0372  CL103 HEK-293T C438(0.86); C148(1.08)  LDD1576  [18]
 LDCM0373  CL104 HEK-293T C438(1.07); C148(1.15)  LDD1577  [18]
 LDCM0374  CL105 HEK-293T C438(0.97); C148(1.04)  LDD1578  [18]
 LDCM0375  CL106 HEK-293T C438(0.92); C148(1.04)  LDD1579  [18]
 LDCM0376  CL107 HEK-293T C438(0.96); C148(1.12)  LDD1580  [18]
 LDCM0377  CL108 HEK-293T C438(1.03); C148(1.24)  LDD1581  [18]
 LDCM0378  CL109 HEK-293T C438(1.00); C148(1.09)  LDD1582  [18]
 LDCM0379  CL11 HEK-293T C438(0.43); C148(0.93)  LDD1583  [18]
 LDCM0380  CL110 HEK-293T C438(0.84); C148(1.00)  LDD1584  [18]
 LDCM0381  CL111 HEK-293T C438(0.92); C148(1.02)  LDD1585  [18]
 LDCM0382  CL112 HEK-293T C438(1.09); C148(1.16)  LDD1586  [18]
 LDCM0383  CL113 HEK-293T C438(1.01); C148(1.16)  LDD1587  [18]
 LDCM0384  CL114 HEK-293T C438(0.98); C148(1.12)  LDD1588  [18]
 LDCM0385  CL115 HEK-293T C438(0.97); C148(1.12)  LDD1589  [18]
 LDCM0386  CL116 HEK-293T C438(1.03); C148(1.34)  LDD1590  [18]
 LDCM0387  CL117 HEK-293T C438(1.09); C148(1.11)  LDD1591  [18]
 LDCM0388  CL118 HEK-293T C438(0.95); C148(1.13)  LDD1592  [18]
 LDCM0389  CL119 HEK-293T C438(0.91); C148(1.19)  LDD1593  [18]
 LDCM0390  CL12 HEK-293T C438(0.50); C148(0.91)  LDD1594  [18]
 LDCM0391  CL120 HEK-293T C438(1.04); C148(1.22)  LDD1595  [18]
 LDCM0392  CL121 HEK-293T C438(1.12); C148(1.13)  LDD1596  [18]
 LDCM0393  CL122 HEK-293T C438(1.03); C148(1.18)  LDD1597  [18]
 LDCM0394  CL123 HEK-293T C438(0.95); C148(1.06)  LDD1598  [18]
 LDCM0395  CL124 HEK-293T C438(1.19); C148(1.18)  LDD1599  [18]
 LDCM0396  CL125 HEK-293T C438(2.27); C148(1.02)  LDD1600  [18]
 LDCM0397  CL126 HEK-293T C438(1.36); C148(1.13)  LDD1601  [18]
 LDCM0398  CL127 HEK-293T C438(1.41); C148(1.01)  LDD1602  [18]
 LDCM0399  CL128 HEK-293T C438(1.55); C148(1.06)  LDD1603  [18]
 LDCM0400  CL13 HEK-293T C438(1.01); C148(0.93)  LDD1604  [18]
 LDCM0401  CL14 HEK-293T C438(0.86); C148(1.08)  LDD1605  [18]
 LDCM0402  CL15 HEK-293T C438(0.63); C148(0.92)  LDD1606  [18]
 LDCM0403  CL16 HEK-293T C438(0.76); C148(1.12)  LDD1607  [18]
 LDCM0404  CL17 HEK-293T C438(0.64); C148(0.92)  LDD1608  [18]
 LDCM0405  CL18 HEK-293T C438(0.70); C148(1.10)  LDD1609  [18]
 LDCM0406  CL19 HEK-293T C438(0.58); C148(1.08)  LDD1610  [18]
 LDCM0407  CL2 HEK-293T C438(0.83); C148(1.03)  LDD1611  [18]
 LDCM0408  CL20 HEK-293T C438(0.52); C148(1.01)  LDD1612  [18]
 LDCM0409  CL21 HEK-293T C438(0.40); C148(0.98)  LDD1613  [18]
 LDCM0410  CL22 HEK-293T C438(0.39); C148(0.94); C493(0.91)  LDD1614  [18]
 LDCM0411  CL23 HEK-293T C438(0.42); C148(0.97)  LDD1615  [18]
 LDCM0412  CL24 HEK-293T C438(0.52); C148(0.94)  LDD1616  [18]
 LDCM0413  CL25 HEK-293T C438(1.46); C148(1.00)  LDD1617  [18]
 LDCM0414  CL26 HEK-293T C438(0.94); C148(1.01)  LDD1618  [18]
 LDCM0415  CL27 HEK-293T C438(0.93); C148(1.10)  LDD1619  [18]
 LDCM0416  CL28 HEK-293T C438(0.90); C148(1.06)  LDD1620  [18]
 LDCM0417  CL29 HEK-293T C438(0.83); C148(1.08)  LDD1621  [18]
 LDCM0418  CL3 HEK-293T C438(0.78); C148(1.06)  LDD1622  [18]
 LDCM0419  CL30 HEK-293T C438(0.81); C148(1.11)  LDD1623  [18]
 LDCM0420  CL31 HEK-293T C438(0.64); C148(1.11)  LDD1624  [18]
 LDCM0421  CL32 HEK-293T C438(0.64); C148(1.04)  LDD1625  [18]
 LDCM0422  CL33 HEK-293T C438(0.43); C148(0.85)  LDD1626  [18]
 LDCM0423  CL34 HEK-293T C438(0.41); C148(0.95); C493(0.81)  LDD1627  [18]
 LDCM0424  CL35 HEK-293T C438(0.38); C148(0.95)  LDD1628  [18]
 LDCM0425  CL36 HEK-293T C438(0.48); C148(1.03)  LDD1629  [18]
 LDCM0426  CL37 HEK-293T C438(1.73); C148(0.99)  LDD1630  [18]
 LDCM0428  CL39 HEK-293T C438(0.91); C148(1.04)  LDD1632  [18]
 LDCM0429  CL4 HEK-293T C438(0.89); C148(0.94)  LDD1633  [18]
 LDCM0430  CL40 HEK-293T C438(0.94); C148(1.08)  LDD1634  [18]
 LDCM0431  CL41 HEK-293T C438(0.87); C148(0.99)  LDD1635  [18]
 LDCM0432  CL42 HEK-293T C438(0.97); C148(1.02)  LDD1636  [18]
 LDCM0433  CL43 HEK-293T C438(0.62); C148(1.09)  LDD1637  [18]
 LDCM0434  CL44 HEK-293T C438(0.69); C148(0.97)  LDD1638  [18]
 LDCM0435  CL45 HEK-293T C438(0.49); C148(0.92)  LDD1639  [18]
 LDCM0436  CL46 HEK-293T C438(0.42); C148(0.90); C493(0.80)  LDD1640  [18]
 LDCM0437  CL47 HEK-293T C438(0.38); C148(0.94)  LDD1641  [18]
 LDCM0438  CL48 HEK-293T C438(0.57); C148(0.87)  LDD1642  [18]
 LDCM0439  CL49 HEK-293T C438(1.70); C148(1.12)  LDD1643  [18]
 LDCM0440  CL5 HEK-293T C438(0.97); C148(0.94)  LDD1644  [18]
 LDCM0441  CL50 HEK-293T C438(0.88); C148(1.04)  LDD1645  [18]
 LDCM0443  CL52 HEK-293T C438(0.91); C148(1.11)  LDD1646  [18]
 LDCM0444  CL53 HEK-293T C438(0.80); C148(0.99)  LDD1647  [18]
 LDCM0445  CL54 HEK-293T C438(0.73); C148(1.06)  LDD1648  [18]
 LDCM0446  CL55 HEK-293T C438(0.61); C148(0.99)  LDD1649  [18]
 LDCM0447  CL56 HEK-293T C438(0.62); C148(0.99)  LDD1650  [18]
 LDCM0448  CL57 HEK-293T C438(0.49); C148(0.85)  LDD1651  [18]
 LDCM0449  CL58 HEK-293T C438(0.43); C148(0.98); C493(0.93)  LDD1652  [18]
 LDCM0450  CL59 HEK-293T C438(0.45); C148(0.99)  LDD1653  [18]
 LDCM0451  CL6 HEK-293T C438(0.78); C148(0.94)  LDD1654  [18]
 LDCM0452  CL60 HEK-293T C438(0.53); C148(0.97)  LDD1655  [18]
 LDCM0453  CL61 HEK-293T C438(2.13); C148(1.07)  LDD1656  [18]
 LDCM0454  CL62 HEK-293T C438(1.06); C148(1.13)  LDD1657  [18]
 LDCM0455  CL63 HEK-293T C438(0.98); C148(1.09)  LDD1658  [18]
 LDCM0456  CL64 HEK-293T C438(0.94); C148(1.10)  LDD1659  [18]
 LDCM0457  CL65 HEK-293T C438(0.99); C148(1.02)  LDD1660  [18]
 LDCM0458  CL66 HEK-293T C438(1.01); C148(1.01)  LDD1661  [18]
 LDCM0459  CL67 HEK-293T C438(0.69); C148(1.21)  LDD1662  [18]
 LDCM0460  CL68 HEK-293T C438(0.63); C148(1.04)  LDD1663  [18]
 LDCM0461  CL69 HEK-293T C438(0.58); C148(1.01)  LDD1664  [18]
 LDCM0462  CL7 HEK-293T C438(0.66); C148(1.00)  LDD1665  [18]
 LDCM0463  CL70 HEK-293T C438(0.47); C148(0.98); C493(0.74)  LDD1666  [18]
 LDCM0464  CL71 HEK-293T C438(0.49); C148(0.99)  LDD1667  [18]
 LDCM0465  CL72 HEK-293T C438(0.55); C148(0.97)  LDD1668  [18]
 LDCM0466  CL73 HEK-293T C438(1.63); C148(1.03)  LDD1669  [18]
 LDCM0467  CL74 HEK-293T C438(1.24); C148(1.13)  LDD1670  [18]
 LDCM0469  CL76 HEK-293T C438(1.10); C148(1.13)  LDD1672  [18]
 LDCM0470  CL77 HEK-293T C438(0.98); C148(0.99)  LDD1673  [18]
 LDCM0471  CL78 HEK-293T C438(0.92); C148(1.10)  LDD1674  [18]
 LDCM0472  CL79 HEK-293T C438(0.77); C148(1.04)  LDD1675  [18]
 LDCM0473  CL8 HEK-293T C438(0.50); C148(0.87)  LDD1676  [18]
 LDCM0474  CL80 HEK-293T C438(0.75); C148(1.10)  LDD1677  [18]
 LDCM0475  CL81 HEK-293T C438(0.60); C148(1.01)  LDD1678  [18]
 LDCM0476  CL82 HEK-293T C438(0.53); C148(1.06); C493(0.96)  LDD1679  [18]
 LDCM0477  CL83 HEK-293T C438(0.54); C148(0.99)  LDD1680  [18]
 LDCM0478  CL84 HEK-293T C438(0.65); C148(0.98)  LDD1681  [18]
 LDCM0479  CL85 HEK-293T C438(5.44); C148(1.06)  LDD1682  [18]
 LDCM0480  CL86 HEK-293T C438(2.41); C148(1.12)  LDD1683  [18]
 LDCM0481  CL87 HEK-293T C438(1.93); C148(1.04)  LDD1684  [18]
 LDCM0482  CL88 HEK-293T C438(1.64); C148(1.13)  LDD1685  [18]
 LDCM0483  CL89 HEK-293T C438(1.50); C148(1.02)  LDD1686  [18]
 LDCM0484  CL9 HEK-293T C438(0.47); C148(0.93)  LDD1687  [18]
 LDCM0485  CL90 HEK-293T C438(0.96); C148(0.88)  LDD1688  [18]
 LDCM0486  CL91 HEK-293T C438(1.06); C148(1.06)  LDD1689  [18]
 LDCM0487  CL92 HEK-293T C438(0.98); C148(1.02)  LDD1690  [18]
 LDCM0488  CL93 HEK-293T C438(0.66); C148(1.01)  LDD1691  [18]
 LDCM0489  CL94 HEK-293T C438(0.64); C148(0.94); C493(0.87)  LDD1692  [18]
 LDCM0490  CL95 HEK-293T C438(0.58); C148(0.83)  LDD1693  [18]
 LDCM0491  CL96 HEK-293T C438(1.53); C148(0.90)  LDD1694  [18]
 LDCM0492  CL97 HEK-293T C438(1.11); C148(0.99)  LDD1695  [18]
 LDCM0493  CL98 HEK-293T C438(1.03); C148(1.10)  LDD1696  [18]
 LDCM0494  CL99 HEK-293T C438(1.33); C148(1.08)  LDD1697  [18]
 LDCM0495  E2913 HEK-293T C438(0.97); C148(1.08)  LDD1698  [18]
 LDCM0625  F8 Ramos C438(1.44); C272(3.06)  LDD2187  [19]
 LDCM0572  Fragment10 Ramos C438(1.07); C272(1.08)  LDD2189  [19]
 LDCM0573  Fragment11 Ramos C438(0.97); C272(3.31)  LDD2190  [19]
 LDCM0574  Fragment12 Ramos C438(0.76); C272(0.57)  LDD2191  [19]
 LDCM0575  Fragment13 Ramos C438(1.11); C272(1.66)  LDD2192  [19]
 LDCM0576  Fragment14 Ramos C438(0.31); C272(0.71)  LDD2193  [19]
 LDCM0579  Fragment20 Ramos C438(0.87); C272(0.76)  LDD2194  [19]
 LDCM0580  Fragment21 Ramos C438(1.20); C272(1.19)  LDD2195  [19]
 LDCM0582  Fragment23 Ramos C438(1.60); C272(1.76)  LDD2196  [19]
 LDCM0578  Fragment27 Ramos C438(1.35); C272(1.82)  LDD2197  [19]
 LDCM0586  Fragment28 Ramos C438(0.41); C272(0.86)  LDD2198  [19]
 LDCM0588  Fragment30 Ramos C438(1.36); C272(1.62)  LDD2199  [19]
 LDCM0589  Fragment31 Ramos C438(0.89); C272(1.72)  LDD2200  [19]
 LDCM0590  Fragment32 Ramos C438(1.28); C272(1.96)  LDD2201  [19]
 LDCM0468  Fragment33 HEK-293T C438(1.08); C148(1.13)  LDD1671  [18]
 LDCM0596  Fragment38 Ramos C438(0.84); C272(1.82)  LDD2203  [19]
 LDCM0566  Fragment4 Ramos C438(0.59); C272(1.03)  LDD2184  [19]
 LDCM0427  Fragment51 HEK-293T C438(0.96); C148(1.07)  LDD1631  [18]
 LDCM0610  Fragment52 Ramos C438(1.37); C272(1.56)  LDD2204  [19]
 LDCM0614  Fragment56 Ramos C438(1.33); C272(1.71)  LDD2205  [19]
 LDCM0569  Fragment7 Ramos C438(0.56); C272(0.83)  LDD2186  [19]
 LDCM0571  Fragment9 Ramos C438(0.86); C272(0.84)  LDD2188  [19]
 LDCM0022  KB02 HEK-293T C438(1.17); C148(0.89); C493(1.24)  LDD1492  [18]
 LDCM0023  KB03 HEK-293T C438(1.04); C148(1.00); C493(1.22)  LDD1497  [18]
 LDCM0024  KB05 HMCB C155(2.07)  LDD3312  [4]
 LDCM0497  Nucleophilic fragment 11b MDA-MB-231 C272(1.06)  LDD2090  [17]
 LDCM0499  Nucleophilic fragment 12b MDA-MB-231 C272(0.98)  LDD2092  [17]
 LDCM0501  Nucleophilic fragment 13b MDA-MB-231 C272(1.24)  LDD2094  [17]
 LDCM0503  Nucleophilic fragment 14b MDA-MB-231 C272(1.05)  LDD2096  [17]
 LDCM0505  Nucleophilic fragment 15b MDA-MB-231 C272(0.99)  LDD2098  [17]
 LDCM0506  Nucleophilic fragment 16a MDA-MB-231 C438(0.64)  LDD2099  [17]
 LDCM0507  Nucleophilic fragment 16b MDA-MB-231 C272(0.86)  LDD2100  [17]
 LDCM0511  Nucleophilic fragment 18b MDA-MB-231 C272(0.75)  LDD2104  [17]
 LDCM0512  Nucleophilic fragment 19a MDA-MB-231 C272(1.46)  LDD2105  [17]
 LDCM0513  Nucleophilic fragment 19b MDA-MB-231 C272(0.44)  LDD2106  [17]
 LDCM0515  Nucleophilic fragment 20b MDA-MB-231 C272(0.56)  LDD2108  [17]
 LDCM0516  Nucleophilic fragment 21a MDA-MB-231 C438(1.10)  LDD2109  [17]
 LDCM0518  Nucleophilic fragment 22a MDA-MB-231 C438(1.05)  LDD2111  [17]
 LDCM0521  Nucleophilic fragment 23b MDA-MB-231 C272(0.73)  LDD2114  [17]
 LDCM0523  Nucleophilic fragment 24b MDA-MB-231 C272(1.03)  LDD2116  [17]
 LDCM0525  Nucleophilic fragment 25b MDA-MB-231 C272(1.03)  LDD2118  [17]
 LDCM0527  Nucleophilic fragment 26b MDA-MB-231 C272(0.95)  LDD2120  [17]
 LDCM0529  Nucleophilic fragment 27b MDA-MB-231 C272(0.98)  LDD2122  [17]
 LDCM0530  Nucleophilic fragment 28a MDA-MB-231 C438(0.61)  LDD2123  [17]
 LDCM0531  Nucleophilic fragment 28b MDA-MB-231 C272(1.06)  LDD2124  [17]
 LDCM0532  Nucleophilic fragment 29a MDA-MB-231 C438(0.66)  LDD2125  [17]
 LDCM0533  Nucleophilic fragment 29b MDA-MB-231 C272(1.14)  LDD2126  [17]
 LDCM0534  Nucleophilic fragment 30a MDA-MB-231 C438(0.99)  LDD2127  [17]
 LDCM0536  Nucleophilic fragment 31 MDA-MB-231 C438(0.76)  LDD2129  [17]
 LDCM0543  Nucleophilic fragment 38 MDA-MB-231 C438(0.96)  LDD2136  [17]
 LDCM0544  Nucleophilic fragment 39 MDA-MB-231 C438(0.95)  LDD2137  [17]
 LDCM0546  Nucleophilic fragment 40 MDA-MB-231 C438(0.75)  LDD2140  [17]
 LDCM0547  Nucleophilic fragment 41 MDA-MB-231 C272(0.71)  LDD2141  [17]
 LDCM0549  Nucleophilic fragment 43 MDA-MB-231 C272(1.32)  LDD2143  [17]
 LDCM0550  Nucleophilic fragment 5a MDA-MB-231 C438(2.01)  LDD2144  [17]
 LDCM0555  Nucleophilic fragment 7b MDA-MB-231 C272(1.16)  LDD2149  [17]
 LDCM0559  Nucleophilic fragment 9b MDA-MB-231 C272(1.56)  LDD2153  [17]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 3 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
2'-5'-oligoadenylate synthase-like protein (OASL) 2-5A synthase family Q15646
Cyclin-dependent kinase 9 (CDK9) CMGC Ser/Thr protein kinase family P50750
Leucine-rich repeat serine/threonine-protein kinase 2 (LRRK2) TKL Ser/Thr protein kinase family Q5S007
Other
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Protein HEXIM1 (HEXIM1) HEXIM family O94992

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
3 2H-Azirine-Based Reagents for Chemoselective Bioconjugation at Carboxyl Residues Inside Live Cells. J Am Chem Soc. 2020 Apr 1;142(13):6051-6059. doi: 10.1021/jacs.9b12116. Epub 2020 Mar 23.
4 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
5 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
6 Targeted Proteomic Approaches for Proteome-Wide Characterizations of the AMP-Binding Capacities of Kinases. J Proteome Res. 2022 Aug 5;21(8):2063-2070. doi: 10.1021/acs.jproteome.2c00225. Epub 2022 Jul 12.
7 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
8 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
9 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
10 DFT-Guided Discovery of Ethynyl-Triazolyl-Phosphinates as Modular Electrophiles for Chemoselective Cysteine Bioconjugation and Profiling. Angew Chem Int Ed Engl. 2022 Oct 10;61(41):e202205348. doi: 10.1002/anie.202205348. Epub 2022 Aug 22.
Mass spectrometry data entry: PXD033004
11 Tunable Amine-Reactive Electrophiles for Selective Profiling of Lysine. Angew Chem Int Ed Engl. 2022 Jan 26;61(5):e202112107. doi: 10.1002/anie.202112107. Epub 2021 Dec 16.
12 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
13 Oxidant-Induced Bioconjugation for Protein Labeling in Live Cells. ACS Chem Biol. 2023 Jan 20;18(1):112-122. doi: 10.1021/acschembio.2c00740. Epub 2022 Dec 21.
14 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
15 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
16 Pharmacological Targeting of Vacuolar H(+)-ATPase via Subunit V1G Combats Multidrug-Resistant Cancer. Cell Chem Biol. 2020 Nov 19;27(11):1359-1370.e8. doi: 10.1016/j.chembiol.2020.06.011. Epub 2020 Jul 9.
17 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
18 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
19 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578