Details of the Target

General Information of Target

Target ID LDTP06716
Target Name Ral GTPase-activating protein subunit alpha-2 (RALGAPA2)
Gene Name RALGAPA2
Gene ID 57186
Synonyms
C20orf74; KIAA1272; Ral GTPase-activating protein subunit alpha-2; 250 kDa substrate of Akt; AS250; p220
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MFSRRSHGDVKKSTQKVLDPKKDVLTRLKHLRALLDNVDANDLKQFFETNYSQIYFIFYE
NFIALENSLKLKGNNKSQREELDSILFLFEKILQFLPERIFFRWHYQSIGSTLKKLLHTG
NSIKIRCEGIRLFLLWLQALQTNCAEEQVLIFACLVPGFPAVMSSRGPCTLETLINPSPS
VADVKIYPEEITPLLPAISGEKIAEDQTCFFLQILLKYMVIQAASLEWKNKENQDTGFKF
LFTLFRKYYLPHLFPSFTKLTNIYKPVLDIPHLRPKPVYITTTRDNENIYSTKIPYMAAR
VVFIKWIVTFFLEKKYLTATQNTKNGVDVLPKIIQTVGGGAVQERAPELDGGGPTEQDKS
HSNSSTLSDRRLSNSSLCSIEEEHRMVYEMVQRILLSTRGYVNFVNEVFHQAFLLPSCEI
AVTRKVVQVYRKWILQDKPVFMEEPDRKDVAQEDAEKLGFSETDSKEASSESSGHKRSSS
WGRTYSFTSAMSRGCVTEEENTNVKAGVQALLQVFLTNSANIFLLEPCAEVPVLLKEQVD
ACKAVLIIFRRMIMELTMNKKTWEQMLQILLRITEAVMQKPKDKQIKDLFAQSLAGLLFR
TLMVAWIRANLCVYISRELWDDFLGVLSSLTEWEELINEWANIMDSLTAVLARTVYGVEM
TNLPLDKLSEQKEKKQRGKGCVLDPQKGTTVGRSFSLSWRSHPDVTEPMRFRSATTSGAP
GVEKARNIVRQKATEVEECQQSENAPAAGSGHLTVGQQQQVLRSSSTSDIPEPLCSDSSQ
GQKAENTQNSSSSEPQPIQENKGHVKREHEGITILVRRSSSPAELDLKDDLQQTQGKCRE
RQKSESTNSDTTLGCTNEAELSMGPWQTCEEDPELNTPTDVVADADARHWLQLSPTDASN
LTDSSECLTDDCSIIAGGSLTGWHPDSAAVLWRRVLGILGDVNNIQSPKIHARVFCYLYE
LWYKLAKIRDNLAISLDNQSSPSPPVLIPPLRMFASWLFKAATLPNEYKEGKLQAYRLIC
AMMTRRQDVLPNSDFLVHFYLVMHLGLTSEDQDILNTIIRHCPPRFFSLGFPGFSMLVGD
FITAAARVLSTDILTAPRSEAVTVLGSLVCFPNTYQEIPLLQSVPEVNEAITGTEDVKHY
LINILLKNATEEPNEYARCIAVCSLGVWICEELAQCTSHPQVKEAINVIGVTLKFPNKIV
AQVACDVLQLLVSYWEKLQMFETSLPRKMAEILVATVAFLLPSAEYSSVETDKKFIVSLL
LCLLDWCMALPVSVLLHPVSTAVLEEQHSARAPLLDYIYRVLHCCVCGSSTYTQQSHYIL
TLADLSSTDYDPFLPLANVKSSEPVQYHSSAELGNLLTVEEEKKRRSLELIPLTARMVMA
HLVNHLGHYPLSGGPAILHSLVSENHDNAHVEGSELSFEVFRSPNLQLFVFNDSTLISYL
QTPTEGPVGGSPVGSLSDVRVIVRDISGKYSWDGKVLYGPLEGCLAPNGRNPSFLISSWH
RDTFGPQKDSSQVEEGDDVLDKLLENIGHTSPECLLPSQLNLNEPSLTPCGMNYDQEKEI
IEVILRQNAQEDEYIQSHNFDSAMKVTSQGQPSPVEPRGPFYFCRLLLDDLGMNSWDRRK
NFHLLKKNSKLLRELKNLDSRQCRETHKIAVFYIAEGQEDKCSILSNERGSQAYEDFVAG
LGWEVDLSTHCGFMGGLQRNGSTGQTAPYYATSTVEVIFHVSTRMPSDSDDSLTKKLRHL
GNDEVHIVWSEHSRDYRRGIIPTAFGDVSIIIYPMKNHMFFIAITKKPEVPFFGPLFDGA
IVSGKLLPSLVCATCINASRAVKCLIPLYQSFYEERALYLEAIIQNHREVMTFEDFAAQV
FSPSPSYSLSGTD
Target Bioclass
Other
Subcellular location
Cytoplasm
Function Catalytic subunit of the heterodimeric RalGAP2 complex which acts as a GTPase activator for the Ras-like small GTPases RALA and RALB.
Uniprot ID
Q2PPJ7
Ensemble ID
ENST00000202677.12
HGNC ID
HGNC:16207

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
42MGBA SNV: p.E500G .
786O Insertion: p.M390NfsTer18 .
A375 SNV: p.S1164F .
AGS SNV: p.K91N .
HCC827 Substitution: p.L1357R DBIA    Probe Info 
HUPT3 SNV: p.K11M .
KELLY Substitution: p.W633M .
KNS81FD SNV: p.I186V .
LN18 SNV: p.L516V .
LS180 SNV: p.W563R .
MCC13 SNV: p.R992K .
MEWO SNV: p.S750C; p.L762F DBIA    Probe Info 
MFE296 Deletion: p.N325MfsTer81 .
MFE319 Insertion: p.Q411_A412insCVCVC .
MM1S SNV: p.I553V .
MOLT4 SNV: p.T119A IA-alkyne    Probe Info 
SKMM2 SNV: p.K1626R .
SUPT1 SNV: p.A1783V .
SW403 SNV: p.L212I DBIA    Probe Info 
TOV21G SNV: p.Q1202K .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 5 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
IPM
 Probe Info  		N.A.  LDD0241  [1]
AHL-Pu-1
 Probe Info  		C495(2.38)  LDD0168  [2]
DBIA
 Probe Info  		C1662(24.44)  LDD0209  [3]
IA-alkyne
 Probe Info  		N.A.  LDD0167  [4]
NAIA_5
 Probe Info  		C739(0.00); C775(0.00)  LDD2224  [5]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0025  4SU-RNA HEK-293T C495(2.38)  LDD0168  [2]
 LDCM0026  4SU-RNA+native RNA HEK-293T C495(2.03)  LDD0169  [2]
 LDCM0214  AC1 HEK-293T C1604(1.02)  LDD0812  [6]
 LDCM0215  AC10 PaTu 8988t C495(1.68); C956(1.25)  LDD1094  [6]
 LDCM0226  AC11 PaTu 8988t C495(1.29); C956(1.31)  LDD1105  [6]
 LDCM0237  AC12 PaTu 8988t C495(1.40); C956(1.34)  LDD1116  [6]
 LDCM0246  AC128 HEK-293T C1484(0.78); C1604(0.96)  LDD0844  [6]
 LDCM0247  AC129 HEK-293T C1484(1.07); C1604(0.87)  LDD0845  [6]
 LDCM0249  AC130 HEK-293T C1484(0.36); C1604(1.19)  LDD0847  [6]
 LDCM0250  AC131 HEK-293T C1484(0.71); C1604(1.15)  LDD0848  [6]
 LDCM0251  AC132 HEK-293T C1484(0.34); C1604(0.83)  LDD0849  [6]
 LDCM0252  AC133 HEK-293T C1484(0.26); C1604(0.81)  LDD0850  [6]
 LDCM0253  AC134 HEK-293T C1484(0.31); C1604(1.59)  LDD0851  [6]
 LDCM0254  AC135 HEK-293T C1484(0.47); C1604(0.90)  LDD0852  [6]
 LDCM0255  AC136 HEK-293T C1484(0.41); C1604(0.95)  LDD0853  [6]
 LDCM0256  AC137 HEK-293T C1484(0.26); C1604(1.08)  LDD0854  [6]
 LDCM0257  AC138 HEK-293T C1484(0.24); C1604(0.89)  LDD0855  [6]
 LDCM0258  AC139 HEK-293T C1484(0.35); C1604(1.11)  LDD0856  [6]
 LDCM0259  AC14 PaTu 8988t C495(1.46); C956(1.09)  LDD1138  [6]
 LDCM0260  AC140 HEK-293T C1484(0.27); C1604(1.37)  LDD0858  [6]
 LDCM0261  AC141 HEK-293T C1484(0.22); C1604(0.89)  LDD0859  [6]
 LDCM0262  AC142 HEK-293T C1484(0.26); C1604(1.20)  LDD0860  [6]
 LDCM0263  AC143 PaTu 8988t C956(1.33)  LDD1142  [6]
 LDCM0264  AC144 PaTu 8988t C956(1.08)  LDD1143  [6]
 LDCM0265  AC145 PaTu 8988t C956(1.11)  LDD1144  [6]
 LDCM0266  AC146 PaTu 8988t C956(1.15)  LDD1145  [6]
 LDCM0267  AC147 PaTu 8988t C956(1.06)  LDD1146  [6]
 LDCM0268  AC148 PaTu 8988t C956(1.70)  LDD1147  [6]
 LDCM0269  AC149 PaTu 8988t C956(1.48)  LDD1148  [6]
 LDCM0270  AC15 PaTu 8988t C495(1.67); C956(1.10)  LDD1149  [6]
 LDCM0271  AC150 PaTu 8988t C956(1.06)  LDD1150  [6]
 LDCM0272  AC151 PaTu 8988t C956(1.28)  LDD1151  [6]
 LDCM0273  AC152 PaTu 8988t C956(1.22)  LDD1152  [6]
 LDCM0274  AC153 PaTu 8988t C956(1.45)  LDD1153  [6]
 LDCM0621  AC154 PaTu 8988t C956(1.30)  LDD2166  [6]
 LDCM0622  AC155 PaTu 8988t C956(1.27)  LDD2167  [6]
 LDCM0623  AC156 PaTu 8988t C956(1.23)  LDD2168  [6]
 LDCM0624  AC157 PaTu 8988t C956(0.94)  LDD2169  [6]
 LDCM0276  AC17 HEK-293T C1484(0.29)  LDD0874  [6]
 LDCM0277  AC18 HEK-293T C1484(0.32)  LDD0875  [6]
 LDCM0278  AC19 HEK-293T C1484(0.37)  LDD0876  [6]
 LDCM0279  AC2 HEK-293T C1604(0.93)  LDD0877  [6]
 LDCM0280  AC20 HEK-293T C1484(0.30)  LDD0878  [6]
 LDCM0281  AC21 HEK-293T C1484(0.38)  LDD0879  [6]
 LDCM0282  AC22 HEK-293T C1484(0.33)  LDD0880  [6]
 LDCM0283  AC23 HEK-293T C1484(0.20)  LDD0881  [6]
 LDCM0284  AC24 HEK-293T C1484(0.46)  LDD0882  [6]
 LDCM0285  AC25 HEK-293T C1484(0.72); C1604(1.30)  LDD0883  [6]
 LDCM0286  AC26 HEK-293T C1484(0.55); C1604(1.75)  LDD0884  [6]
 LDCM0287  AC27 HEK-293T C1484(0.53); C1604(1.54)  LDD0885  [6]
 LDCM0288  AC28 HEK-293T C1484(3.25); C1604(1.16)  LDD0886  [6]
 LDCM0289  AC29 HEK-293T C1484(0.58); C1604(1.60)  LDD0887  [6]
 LDCM0290  AC3 HEK-293T C1604(1.39)  LDD0888  [6]
 LDCM0291  AC30 HEK-293T C1484(0.47); C1604(1.80)  LDD0889  [6]
 LDCM0292  AC31 HEK-293T C1484(0.83); C1604(1.34)  LDD0890  [6]
 LDCM0293  AC32 HEK-293T C1484(0.76); C1604(1.45)  LDD0891  [6]
 LDCM0294  AC33 HEK-293T C1484(0.47); C1604(1.79)  LDD0892  [6]
 LDCM0295  AC34 HEK-293T C1484(0.74); C1604(1.70)  LDD0893  [6]
 LDCM0296  AC35 HEK-293T C1604(0.78)  LDD0894  [6]
 LDCM0297  AC36 HEK-293T C1604(0.64)  LDD0895  [6]
 LDCM0298  AC37 HEK-293T C1604(1.13)  LDD0896  [6]
 LDCM0299  AC38 HEK-293T C1604(0.85)  LDD0897  [6]
 LDCM0300  AC39 HEK-293T C1604(0.67)  LDD0898  [6]
 LDCM0301  AC4 HEK-293T C1604(1.28)  LDD0899  [6]
 LDCM0302  AC40 HEK-293T C1604(0.82)  LDD0900  [6]
 LDCM0303  AC41 HEK-293T C1604(0.97)  LDD0901  [6]
 LDCM0304  AC42 HEK-293T C1604(0.78)  LDD0902  [6]
 LDCM0305  AC43 HEK-293T C1604(0.72)  LDD0903  [6]
 LDCM0306  AC44 HEK-293T C1604(0.83)  LDD0904  [6]
 LDCM0307  AC45 HEK-293T C1604(0.71)  LDD0905  [6]
 LDCM0308  AC46 PaTu 8988t C1484(1.03); C956(1.30)  LDD1187  [6]
 LDCM0309  AC47 PaTu 8988t C1484(1.33); C956(1.28)  LDD1188  [6]
 LDCM0310  AC48 PaTu 8988t C1484(1.31); C956(1.41)  LDD1189  [6]
 LDCM0311  AC49 PaTu 8988t C1484(1.56); C956(1.60)  LDD1190  [6]
 LDCM0312  AC5 HEK-293T C1604(1.19)  LDD0910  [6]
 LDCM0313  AC50 PaTu 8988t C1484(1.48); C956(1.84)  LDD1192  [6]
 LDCM0314  AC51 PaTu 8988t C1484(0.26); C956(1.42)  LDD1193  [6]
 LDCM0315  AC52 PaTu 8988t C1484(1.44); C956(1.48)  LDD1194  [6]
 LDCM0316  AC53 PaTu 8988t C1484(1.55); C956(2.06)  LDD1195  [6]
 LDCM0317  AC54 PaTu 8988t C1484(1.62); C956(2.19)  LDD1196  [6]
 LDCM0318  AC55 PaTu 8988t C1484(1.17); C956(1.40)  LDD1197  [6]
 LDCM0319  AC56 PaTu 8988t C1484(1.65); C956(1.98)  LDD1198  [6]
 LDCM0320  AC57 HEK-293T C1484(0.79); C1604(1.07)  LDD0918  [6]
 LDCM0321  AC58 HEK-293T C1484(1.01); C1604(1.10)  LDD0919  [6]
 LDCM0322  AC59 HEK-293T C1484(0.88); C1604(1.25)  LDD0920  [6]
 LDCM0323  AC6 PaTu 8988t C495(1.30); C956(1.05)  LDD1202  [6]
 LDCM0324  AC60 HEK-293T C1484(0.84); C1604(0.91)  LDD0922  [6]
 LDCM0325  AC61 HEK-293T C1484(0.95); C1604(1.18)  LDD0923  [6]
 LDCM0326  AC62 HEK-293T C1484(1.14); C1604(0.98)  LDD0924  [6]
 LDCM0327  AC63 HEK-293T C1484(0.91); C1604(1.07)  LDD0925  [6]
 LDCM0328  AC64 HEK-293T C1484(0.81); C1604(1.15)  LDD0926  [6]
 LDCM0329  AC65 HEK-293T C1484(1.31); C1604(1.09)  LDD0927  [6]
 LDCM0330  AC66 HEK-293T C1484(1.05); C1604(1.01)  LDD0928  [6]
 LDCM0331  AC67 HEK-293T C1484(1.15); C1604(1.19)  LDD0929  [6]
 LDCM0332  AC68 HEK-293T C1484(0.92)  LDD0930  [6]
 LDCM0333  AC69 HEK-293T C1484(1.09)  LDD0931  [6]
 LDCM0334  AC7 PaTu 8988t C495(0.85); C956(1.03)  LDD1213  [6]
 LDCM0335  AC70 HEK-293T C1484(0.91)  LDD0933  [6]
 LDCM0336  AC71 HEK-293T C1484(0.85)  LDD0934  [6]
 LDCM0337  AC72 HEK-293T C1484(0.91)  LDD0935  [6]
 LDCM0338  AC73 HEK-293T C1484(0.74)  LDD0936  [6]
 LDCM0339  AC74 HEK-293T C1484(0.94)  LDD0937  [6]
 LDCM0340  AC75 HEK-293T C1484(0.65)  LDD0938  [6]
 LDCM0341  AC76 HEK-293T C1484(0.88)  LDD0939  [6]
 LDCM0342  AC77 HEK-293T C1484(0.96)  LDD0940  [6]
 LDCM0343  AC78 HEK-293T C1484(0.87)  LDD0941  [6]
 LDCM0344  AC79 HEK-293T C1484(1.00)  LDD0942  [6]
 LDCM0345  AC8 PaTu 8988t C495(1.07); C956(0.99)  LDD1224  [6]
 LDCM0346  AC80 HEK-293T C1484(0.95)  LDD0944  [6]
 LDCM0347  AC81 HEK-293T C1484(0.96)  LDD0945  [6]
 LDCM0348  AC82 HEK-293T C1484(0.90)  LDD0946  [6]
 LDCM0349  AC83 HEK-293T C1604(1.18)  LDD0947  [6]
 LDCM0350  AC84 HEK-293T C1604(1.15)  LDD0948  [6]
 LDCM0351  AC85 HEK-293T C1604(0.83)  LDD0949  [6]
 LDCM0352  AC86 HEK-293T C1604(0.88)  LDD0950  [6]
 LDCM0353  AC87 HEK-293T C1604(1.04)  LDD0951  [6]
 LDCM0354  AC88 HEK-293T C1604(0.78)  LDD0952  [6]
 LDCM0355  AC89 HEK-293T C1604(1.05)  LDD0953  [6]
 LDCM0357  AC90 HEK-293T C1604(0.94)  LDD0955  [6]
 LDCM0358  AC91 HEK-293T C1604(0.97)  LDD0956  [6]
 LDCM0359  AC92 HEK-293T C1604(1.22)  LDD0957  [6]
 LDCM0360  AC93 HEK-293T C1604(1.33)  LDD0958  [6]
 LDCM0361  AC94 HEK-293T C1604(1.13)  LDD0959  [6]
 LDCM0362  AC95 HEK-293T C1604(1.38)  LDD0960  [6]
 LDCM0363  AC96 HEK-293T C1604(1.49)  LDD0961  [6]
 LDCM0364  AC97 HEK-293T C1604(1.23)  LDD0962  [6]
 LDCM0248  AKOS034007472 PaTu 8988t C495(1.94); C956(1.38)  LDD1127  [6]
 LDCM0356  AKOS034007680 PaTu 8988t C495(1.50); C956(1.39)  LDD1235  [6]
 LDCM0275  AKOS034007705 PaTu 8988t C495(1.61); C956(1.36)  LDD1154  [6]
 LDCM0367  CL1 HEK-293T C1662(0.96); C739(1.09); C169(1.32); C1824(1.26)  LDD1571  [7]
 LDCM0368  CL10 HEK-293T C1662(0.95); C169(1.55); C209(1.57); C418(1.47)  LDD1572  [7]
 LDCM0369  CL100 HEK-293T C1604(1.52)  LDD0967  [6]
 LDCM0370  CL101 PaTu 8988t C495(1.29); C956(1.16)  LDD1249  [6]
 LDCM0371  CL102 PaTu 8988t C495(1.10); C956(1.07)  LDD1250  [6]
 LDCM0372  CL103 PaTu 8988t C495(1.87); C956(1.63)  LDD1251  [6]
 LDCM0373  CL104 PaTu 8988t C495(1.36); C956(1.35)  LDD1252  [6]
 LDCM0374  CL105 HEK-293T C1484(1.72)  LDD0972  [6]
 LDCM0375  CL106 HEK-293T C1484(1.03)  LDD0973  [6]
 LDCM0376  CL107 HEK-293T C1484(0.49)  LDD0974  [6]
 LDCM0377  CL108 HEK-293T C1484(0.47)  LDD0975  [6]
 LDCM0378  CL109 HEK-293T C1484(1.48)  LDD0976  [6]
 LDCM0379  CL11 HEK-293T C1662(1.00); C739(1.37); C169(1.42); C209(1.29)  LDD1583  [7]
 LDCM0380  CL110 HEK-293T C1484(1.60)  LDD0978  [6]
 LDCM0381  CL111 HEK-293T C1484(1.65)  LDD0979  [6]
 LDCM0382  CL112 HEK-293T C1484(1.74); C1604(1.60)  LDD0980  [6]
 LDCM0383  CL113 HEK-293T C1484(0.85); C1604(1.50)  LDD0981  [6]
 LDCM0384  CL114 HEK-293T C1484(0.66); C1604(2.17)  LDD0982  [6]
 LDCM0385  CL115 HEK-293T C1484(0.49); C1604(1.87)  LDD0983  [6]
 LDCM0386  CL116 HEK-293T C1484(0.65); C1604(1.67)  LDD0984  [6]
 LDCM0387  CL117 HEK-293T C1604(0.68)  LDD0985  [6]
 LDCM0388  CL118 HEK-293T C1604(0.96)  LDD0986  [6]
 LDCM0389  CL119 HEK-293T C1604(0.86)  LDD0987  [6]
 LDCM0390  CL12 HEK-293T C1662(0.99); C739(0.86); C169(1.27); C209(1.20)  LDD1594  [7]
 LDCM0391  CL120 HEK-293T C1604(0.73)  LDD0989  [6]
 LDCM0392  CL121 PaTu 8988t C1484(1.20); C956(1.22)  LDD1271  [6]
 LDCM0393  CL122 PaTu 8988t C1484(1.63); C956(1.52)  LDD1272  [6]
 LDCM0394  CL123 PaTu 8988t C1484(1.70); C956(1.70)  LDD1273  [6]
 LDCM0395  CL124 PaTu 8988t C1484(1.64); C956(1.86)  LDD1274  [6]
 LDCM0396  CL125 HEK-293T C1484(0.85); C1604(0.91)  LDD0994  [6]
 LDCM0397  CL126 HEK-293T C1484(0.70); C1604(1.13)  LDD0995  [6]
 LDCM0398  CL127 HEK-293T C1484(0.97); C1604(1.09)  LDD0996  [6]
 LDCM0399  CL128 HEK-293T C1484(0.92); C1604(0.98)  LDD0997  [6]
 LDCM0400  CL13 HEK-293T C1662(1.02); C739(1.22); C169(1.16); C1824(0.69)  LDD1604  [7]
 LDCM0401  CL14 HEK-293T C1662(1.02); C169(1.01); C1824(0.98); C209(0.90)  LDD1605  [7]
 LDCM0402  CL15 HEK-293T C1662(1.16); C1824(0.68); C209(1.45); C542(1.16)  LDD1606  [7]
 LDCM0403  CL16 HEK-293T C1604(1.65)  LDD1001  [6]
 LDCM0404  CL17 HEK-293T C1604(1.58)  LDD1002  [6]
 LDCM0405  CL18 HEK-293T C1604(1.50)  LDD1003  [6]
 LDCM0406  CL19 HEK-293T C1604(1.10)  LDD1004  [6]
 LDCM0407  CL2 HEK-293T C1662(0.99); C169(0.93); C1824(1.42); C209(1.09)  LDD1611  [7]
 LDCM0408  CL20 HEK-293T C1604(1.33)  LDD1006  [6]
 LDCM0409  CL21 HEK-293T C1604(1.52)  LDD1007  [6]
 LDCM0410  CL22 HEK-293T C1604(1.09)  LDD1008  [6]
 LDCM0411  CL23 HEK-293T C1604(0.99)  LDD1009  [6]
 LDCM0412  CL24 HEK-293T C1604(1.00)  LDD1010  [6]
 LDCM0413  CL25 HEK-293T C1604(1.36)  LDD1011  [6]
 LDCM0414  CL26 HEK-293T C1604(1.13)  LDD1012  [6]
 LDCM0415  CL27 HEK-293T C1604(1.21)  LDD1013  [6]
 LDCM0416  CL28 HEK-293T C1604(1.11)  LDD1014  [6]
 LDCM0417  CL29 HEK-293T C1604(1.07)  LDD1015  [6]
 LDCM0418  CL3 HEK-293T C1662(0.87); C1824(0.95); C209(1.25); C542(1.16)  LDD1622  [7]
 LDCM0419  CL30 HEK-293T C1604(1.62)  LDD1017  [6]
 LDCM0420  CL31 HEK-293T C1484(0.94)  LDD1018  [6]
 LDCM0421  CL32 HEK-293T C1484(1.70)  LDD1019  [6]
 LDCM0422  CL33 HEK-293T C1484(0.74)  LDD1020  [6]
 LDCM0423  CL34 HEK-293T C1484(1.25)  LDD1021  [6]
 LDCM0424  CL35 HEK-293T C1484(1.46)  LDD1022  [6]
 LDCM0425  CL36 HEK-293T C1484(1.45)  LDD1023  [6]
 LDCM0426  CL37 HEK-293T C1484(1.55)  LDD1024  [6]
 LDCM0428  CL39 HEK-293T C1484(1.15)  LDD1026  [6]
 LDCM0429  CL4 HEK-293T C1662(1.06); C169(1.35); C209(1.29); C418(1.22)  LDD1633  [7]
 LDCM0430  CL40 HEK-293T C1484(1.17)  LDD1028  [6]
 LDCM0431  CL41 HEK-293T C1484(0.24)  LDD1029  [6]
 LDCM0432  CL42 HEK-293T C1484(0.39)  LDD1030  [6]
 LDCM0433  CL43 HEK-293T C1484(0.95)  LDD1031  [6]
 LDCM0434  CL44 HEK-293T C1484(1.61)  LDD1032  [6]
 LDCM0435  CL45 HEK-293T C1484(0.38)  LDD1033  [6]
 LDCM0436  CL46 HEK-293T C1604(1.10)  LDD1034  [6]
 LDCM0437  CL47 HEK-293T C1604(1.22)  LDD1035  [6]
 LDCM0438  CL48 HEK-293T C1604(1.19)  LDD1036  [6]
 LDCM0439  CL49 HEK-293T C1604(1.12)  LDD1037  [6]
 LDCM0440  CL5 HEK-293T C1662(0.92); C169(0.93); C209(1.54); C956(1.18)  LDD1644  [7]
 LDCM0441  CL50 HEK-293T C1604(1.33)  LDD1039  [6]
 LDCM0442  CL51 HEK-293T C1604(1.17)  LDD1040  [6]
 LDCM0443  CL52 HEK-293T C1604(1.26)  LDD1041  [6]
 LDCM0444  CL53 HEK-293T C1604(1.04)  LDD1042  [6]
 LDCM0445  CL54 HEK-293T C1604(1.69)  LDD1043  [6]
 LDCM0446  CL55 HEK-293T C1604(0.96)  LDD1044  [6]
 LDCM0447  CL56 HEK-293T C1604(1.06)  LDD1045  [6]
 LDCM0448  CL57 HEK-293T C1604(1.09)  LDD1046  [6]
 LDCM0449  CL58 HEK-293T C1604(0.93)  LDD1047  [6]
 LDCM0450  CL59 HEK-293T C1604(1.22)  LDD1048  [6]
 LDCM0451  CL6 HEK-293T C1662(1.18); C739(0.90); C169(1.24); C209(1.41)  LDD1654  [7]
 LDCM0452  CL60 HEK-293T C1604(1.48)  LDD1050  [6]
 LDCM0453  CL61 HEK-293T C1484(0.78); C1604(1.03)  LDD1051  [6]
 LDCM0454  CL62 HEK-293T C1484(2.22); C1604(1.12)  LDD1052  [6]
 LDCM0455  CL63 HEK-293T C1484(1.65); C1604(1.34)  LDD1053  [6]
 LDCM0456  CL64 HEK-293T C1484(1.11); C1604(1.05)  LDD1054  [6]
 LDCM0457  CL65 HEK-293T C1484(0.65); C1604(1.34)  LDD1055  [6]
 LDCM0458  CL66 HEK-293T C1484(0.97); C1604(1.24)  LDD1056  [6]
 LDCM0459  CL67 HEK-293T C1484(0.63); C1604(0.99)  LDD1057  [6]
 LDCM0460  CL68 HEK-293T C1484(1.36); C1604(1.07)  LDD1058  [6]
 LDCM0461  CL69 HEK-293T C1484(2.00); C1604(0.93)  LDD1059  [6]
 LDCM0462  CL7 HEK-293T C1662(1.07); C739(0.94); C169(1.12); C209(1.09)  LDD1665  [7]
 LDCM0463  CL70 HEK-293T C1484(1.35); C1604(0.99)  LDD1061  [6]
 LDCM0464  CL71 HEK-293T C1484(0.90); C1604(0.95)  LDD1062  [6]
 LDCM0465  CL72 HEK-293T C1484(1.12); C1604(1.01)  LDD1063  [6]
 LDCM0466  CL73 HEK-293T C1484(1.20); C1604(1.04)  LDD1064  [6]
 LDCM0467  CL74 HEK-293T C1484(0.52); C1604(1.54)  LDD1065  [6]
 LDCM0469  CL76 HEK-293T C1484(0.51); C1604(1.15)  LDD1067  [6]
 LDCM0470  CL77 HEK-293T C1484(2.25); C1604(1.31)  LDD1068  [6]
 LDCM0471  CL78 HEK-293T C1484(1.28); C1604(1.55)  LDD1069  [6]
 LDCM0472  CL79 HEK-293T C1484(1.78); C1604(1.25)  LDD1070  [6]
 LDCM0473  CL8 HEK-293T C1662(1.27); C739(0.88); C169(2.29); C209(1.75)  LDD1676  [7]
 LDCM0474  CL80 HEK-293T C1484(0.57); C1604(1.10)  LDD1072  [6]
 LDCM0475  CL81 HEK-293T C1484(0.52); C1604(1.05)  LDD1073  [6]
 LDCM0476  CL82 HEK-293T C1484(2.75); C1604(1.03)  LDD1074  [6]
 LDCM0477  CL83 HEK-293T C1484(2.67); C1604(0.90)  LDD1075  [6]
 LDCM0478  CL84 HEK-293T C1484(1.93); C1604(1.51)  LDD1076  [6]
 LDCM0479  CL85 HEK-293T C1484(0.94); C1604(1.67)  LDD1077  [6]
 LDCM0480  CL86 HEK-293T C1484(0.37); C1604(2.29)  LDD1078  [6]
 LDCM0481  CL87 HEK-293T C1484(0.43); C1604(1.16)  LDD1079  [6]
 LDCM0482  CL88 HEK-293T C1484(3.14); C1604(1.45)  LDD1080  [6]
 LDCM0483  CL89 HEK-293T C1484(1.81); C1604(1.23)  LDD1081  [6]
 LDCM0484  CL9 HEK-293T C1662(1.08); C169(1.10); C209(1.14); C418(1.28)  LDD1687  [7]
 LDCM0485  CL90 HEK-293T C1484(1.24); C1604(1.56)  LDD1083  [6]
 LDCM0486  CL91 HEK-293T C1604(1.39)  LDD1084  [6]
 LDCM0487  CL92 HEK-293T C1604(1.34)  LDD1085  [6]
 LDCM0488  CL93 HEK-293T C1604(1.93)  LDD1086  [6]
 LDCM0489  CL94 HEK-293T C1604(2.33)  LDD1087  [6]
 LDCM0490  CL95 HEK-293T C1604(1.93)  LDD1088  [6]
 LDCM0491  CL96 HEK-293T C1604(1.81)  LDD1089  [6]
 LDCM0492  CL97 HEK-293T C1604(1.24)  LDD1090  [6]
 LDCM0493  CL98 HEK-293T C1604(1.63)  LDD1091  [6]
 LDCM0494  CL99 HEK-293T C1604(1.52)  LDD1092  [6]
 LDCM0495  E2913 HEK-293T C1662(0.91); C1824(0.76); C209(1.10); C542(0.97)  LDD1698  [7]
 LDCM0468  Fragment33 HEK-293T C1484(2.63); C1604(1.43)  LDD1066  [6]
 LDCM0427  Fragment51 HEK-293T C1484(1.36)  LDD1025  [6]
 LDCM0022  KB02 HEK-293T C956(1.06)  LDD1492  [7]
 LDCM0023  KB03 Jurkat C1662(24.44)  LDD0209  [3]
 LDCM0024  KB05 IGR37 C1662(1.62); C1604(2.08)  LDD3314  [8]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Protein DDI1 homolog 1 (DDI1) DDI1 family Q8WTU0

References

1 Oxidant-Induced Bioconjugation for Protein Labeling in Live Cells. ACS Chem Biol. 2023 Jan 20;18(1):112-122. doi: 10.1021/acschembio.2c00740. Epub 2022 Dec 21.
2 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
3 Covalent Inhibition by a Natural Product-Inspired Latent Electrophile. J Am Chem Soc. 2023 May 24;145(20):11097-11109. doi: 10.1021/jacs.3c00598. Epub 2023 May 15.
4 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
5 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
6 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
7 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
8 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840