Details of the Target

General Information of Target

Target ID LDTP06700
Target Name Centrosomal protein kizuna (KIZ)
Gene Name KIZ
Gene ID 55857
Synonyms
C20orf19; NCRNA00153; PLK1S1; Centrosomal protein kizuna; Polo-like kinase 1 substrate 1
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MSRTLASAVPLSSPDYYERLGQLQHGLRDSEKKRLDLEKKLYEYNQSDTCRVKLKYVKLK
NYLKEICESEKKAHTRNQEYLKRFERVQAHVVHFTTNTEKLQKLKLEYETQIKKMLCSKD
SLGLKEELTDEDREKVAVHEGINSGTAMSRGLYQPATIFMGRQMSAILSMRDFSTEHKSP
QPTKNFSIPDPHSHRQTAQSSNVTDSCVVQTSNDTQCLNKSDNIDGKASLQIGEKMPVTA
SVLSEEEQTHCLEIGSNTRHGKSNLSEGKKSAELNSPLRERLSPENRTTDLKCDSSSGSE
GEILTREHIEVEEKRASPPVSPIPVSEYCESENKWSQEKHSPWEGVSDHLAHREPKSQKP
FRKMQEEEEESWSTSSDLTISISEDDLILESPEPQPNPGGKMEGEDGIEALKLIHAEQER
VALSTEKNCILQTLSSPDSEKESSTNAPTREPGQTPDSDVPRAQVGQHVATLKEHDNSVK
EEATALLRKALTEECGRRSAIHSSESSCSLPSILNDNSGIKEAKPAVWLNSVPTREQEVS
SGCGDKSKKENVAADIPITETEAYQLLKKATLQDNTNQTENRFQKTDASVSHLSGLNIGS
GAFETKTANKIASEASFSSSEGSPLSRHENKKKPVINLKSNALWDESDDSNSEIEAALRP
RNHNTDDSDDFYD
Target Bioclass
Other
Family
Kizuna family
Subcellular location
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome
Function
Centrosomal protein required for establishing a robust mitotic centrosome architecture that can endure the forces that converge on the centrosomes during spindle formation. Required for stabilizing the expanded pericentriolar material around the centriole.
Uniprot ID
Q2M2Z5
Ensemble ID
ENST00000616848.4
HGNC ID
HGNC:15865

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
CASKI SNV: p.P322Q .
HCT15 SNV: p.P189H .
HT115 SNV: p.E481Ter .
JURKAT SNV: p.K58N .
LNCaP clone FGC SNV: p.N477D .
MCC26 SNV: p.T576S .
THP1 SNV: p.N575S .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 3 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C207(0.90); C217(0.90)  LDD0078  [1]
IPM
 Probe Info  		N.A.  LDD2156  [2]
Phosphinate-6
 Probe Info  		N.A.  LDD0018  [3]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 PaTu 8988t C207(1.92); C217(1.92)  LDD1093  [1]
 LDCM0215  AC10 HEK-293T C207(2.20); C217(2.20)  LDD0813  [1]
 LDCM0216  AC100 HEK-293T C207(0.86); C217(0.86)  LDD0814  [1]
 LDCM0217  AC101 HEK-293T C207(0.92); C217(0.92)  LDD0815  [1]
 LDCM0218  AC102 HEK-293T C207(0.79); C217(0.79)  LDD0816  [1]
 LDCM0219  AC103 HEK-293T C207(1.09); C217(1.09)  LDD0817  [1]
 LDCM0220  AC104 HEK-293T C207(1.07); C217(1.07)  LDD0818  [1]
 LDCM0221  AC105 HEK-293T C207(0.99); C217(0.99)  LDD0819  [1]
 LDCM0222  AC106 HEK-293T C207(0.80); C217(0.80)  LDD0820  [1]
 LDCM0223  AC107 HEK-293T C207(0.94); C217(0.94)  LDD0821  [1]
 LDCM0224  AC108 HEK-293T C207(0.96); C217(0.96)  LDD0822  [1]
 LDCM0225  AC109 HEK-293T C207(0.84); C217(0.84)  LDD0823  [1]
 LDCM0226  AC11 HEK-293T C207(1.51); C217(1.51)  LDD0824  [1]
 LDCM0227  AC110 HEK-293T C207(0.83); C217(0.83)  LDD0825  [1]
 LDCM0228  AC111 HEK-293T C207(0.87); C217(0.87)  LDD0826  [1]
 LDCM0229  AC112 HEK-293T C207(0.78); C217(0.78)  LDD0827  [1]
 LDCM0230  AC113 HEK-293T C207(1.17); C217(1.17)  LDD0828  [1]
 LDCM0231  AC114 HEK-293T C207(0.85); C217(0.85)  LDD0829  [1]
 LDCM0232  AC115 HEK-293T C207(0.95); C217(0.95)  LDD0830  [1]
 LDCM0233  AC116 HEK-293T C207(0.87); C217(0.87)  LDD0831  [1]
 LDCM0234  AC117 HEK-293T C207(1.22); C217(1.22)  LDD0832  [1]
 LDCM0235  AC118 HEK-293T C207(0.94); C217(0.94)  LDD0833  [1]
 LDCM0236  AC119 HEK-293T C207(0.96); C217(0.96)  LDD0834  [1]
 LDCM0237  AC12 HEK-293T C207(1.25); C217(1.25)  LDD0835  [1]
 LDCM0238  AC120 HEK-293T C207(1.04); C217(1.04)  LDD0836  [1]
 LDCM0239  AC121 HEK-293T C207(0.99); C217(0.99)  LDD0837  [1]
 LDCM0240  AC122 HEK-293T C207(0.92); C217(0.92)  LDD0838  [1]
 LDCM0241  AC123 HEK-293T C207(0.96); C217(0.96)  LDD0839  [1]
 LDCM0242  AC124 HEK-293T C207(1.09); C217(1.09)  LDD0840  [1]
 LDCM0243  AC125 HEK-293T C207(1.30); C217(1.30)  LDD0841  [1]
 LDCM0244  AC126 HEK-293T C207(1.08); C217(1.08)  LDD0842  [1]
 LDCM0245  AC127 HEK-293T C207(1.03); C217(1.03)  LDD0843  [1]
 LDCM0246  AC128 HEK-293T C207(0.96); C217(1.10); C50(0.82)  LDD0844  [1]
 LDCM0247  AC129 HEK-293T C207(1.11); C217(1.35); C50(0.88)  LDD0845  [1]
 LDCM0249  AC130 HEK-293T C207(1.13); C217(1.41); C50(0.85)  LDD0847  [1]
 LDCM0250  AC131 HEK-293T C207(1.10); C217(1.27); C50(0.93)  LDD0848  [1]
 LDCM0251  AC132 HEK-293T C207(1.19); C217(1.49); C50(0.89)  LDD0849  [1]
 LDCM0252  AC133 HEK-293T C207(1.23); C217(1.49); C50(0.97)  LDD0850  [1]
 LDCM0253  AC134 HEK-293T C207(1.03); C217(1.18); C50(0.89)  LDD0851  [1]
 LDCM0254  AC135 HEK-293T C207(0.98); C217(1.13); C50(0.83)  LDD0852  [1]
 LDCM0255  AC136 HEK-293T C207(0.92); C217(1.01); C50(0.82)  LDD0853  [1]
 LDCM0256  AC137 HEK-293T C207(0.91); C217(1.14); C50(0.67)  LDD0854  [1]
 LDCM0257  AC138 HEK-293T C207(0.88); C217(1.14); C50(0.62)  LDD0855  [1]
 LDCM0258  AC139 HEK-293T C207(0.92); C217(1.18); C50(0.67)  LDD0856  [1]
 LDCM0259  AC14 HEK-293T C207(1.78); C217(1.78)  LDD0857  [1]
 LDCM0260  AC140 HEK-293T C207(0.97); C217(1.17); C50(0.76)  LDD0858  [1]
 LDCM0261  AC141 HEK-293T C207(0.91); C217(1.05); C50(0.77)  LDD0859  [1]
 LDCM0262  AC142 HEK-293T C207(0.97); C217(1.15); C50(0.80)  LDD0860  [1]
 LDCM0263  AC143 HEK-293T C207(1.08); C217(1.08)  LDD0861  [1]
 LDCM0264  AC144 HEK-293T C207(0.96); C217(0.96)  LDD0862  [1]
 LDCM0265  AC145 HEK-293T C207(1.21); C217(1.21)  LDD0863  [1]
 LDCM0266  AC146 HEK-293T C207(1.07); C217(1.07)  LDD0864  [1]
 LDCM0267  AC147 HEK-293T C207(0.84); C217(0.84)  LDD0865  [1]
 LDCM0268  AC148 HEK-293T C207(1.01); C217(1.01)  LDD0866  [1]
 LDCM0269  AC149 HEK-293T C207(1.43); C217(1.43)  LDD0867  [1]
 LDCM0270  AC15 HEK-293T C207(1.59); C217(1.59)  LDD0868  [1]
 LDCM0271  AC150 HEK-293T C207(0.99); C217(0.99)  LDD0869  [1]
 LDCM0272  AC151 HEK-293T C207(1.18); C217(1.18)  LDD0870  [1]
 LDCM0273  AC152 HEK-293T C207(1.00); C217(1.00)  LDD0871  [1]
 LDCM0274  AC153 HEK-293T C207(1.04); C217(1.04)  LDD0872  [1]
 LDCM0621  AC154 HEK-293T C207(0.86); C217(0.86)  LDD2162  [1]
 LDCM0622  AC155 HEK-293T C207(1.10); C217(1.10)  LDD2163  [1]
 LDCM0623  AC156 HEK-293T C207(1.16); C217(1.16)  LDD2164  [1]
 LDCM0624  AC157 HEK-293T C207(0.85); C217(0.85)  LDD2165  [1]
 LDCM0276  AC17 HCT 116 C207(0.93); C217(0.93)  LDD0593  [1]
 LDCM0277  AC18 HCT 116 C207(1.17); C217(1.17)  LDD0594  [1]
 LDCM0278  AC19 HCT 116 C207(1.15); C217(1.15)  LDD0595  [1]
 LDCM0279  AC2 PaTu 8988t C207(1.42); C217(1.42)  LDD1158  [1]
 LDCM0280  AC20 HCT 116 C207(1.05); C217(1.05)  LDD0597  [1]
 LDCM0281  AC21 HCT 116 C207(0.96); C217(0.96)  LDD0598  [1]
 LDCM0282  AC22 HCT 116 C207(0.80); C217(0.80)  LDD0599  [1]
 LDCM0283  AC23 HCT 116 C207(0.99); C217(0.99)  LDD0600  [1]
 LDCM0284  AC24 HCT 116 C207(0.83); C217(0.83)  LDD0601  [1]
 LDCM0285  AC25 HEK-293T C207(0.52); C217(0.52)  LDD0883  [1]
 LDCM0286  AC26 HEK-293T C207(0.66); C217(0.66)  LDD0884  [1]
 LDCM0287  AC27 HEK-293T C207(0.56); C217(0.56)  LDD0885  [1]
 LDCM0288  AC28 HEK-293T C207(0.51); C217(0.51)  LDD0886  [1]
 LDCM0289  AC29 HEK-293T C207(0.60); C217(0.60)  LDD0887  [1]
 LDCM0290  AC3 PaTu 8988t C207(1.37); C217(1.37)  LDD1169  [1]
 LDCM0291  AC30 HEK-293T C207(0.65); C217(0.65)  LDD0889  [1]
 LDCM0292  AC31 HEK-293T C207(0.74); C217(0.74)  LDD0890  [1]
 LDCM0293  AC32 HEK-293T C207(0.67); C217(0.67)  LDD0891  [1]
 LDCM0294  AC33 HEK-293T C207(0.59); C217(0.59)  LDD0892  [1]
 LDCM0295  AC34 HEK-293T C207(0.92); C217(0.92)  LDD0893  [1]
 LDCM0296  AC35 HCT 116 C207(1.12); C217(1.12)  LDD0613  [1]
 LDCM0297  AC36 HCT 116 C207(1.06); C217(1.06)  LDD0614  [1]
 LDCM0298  AC37 HCT 116 C207(1.15); C217(1.15)  LDD0615  [1]
 LDCM0299  AC38 HCT 116 C207(1.15); C217(1.15)  LDD0616  [1]
 LDCM0300  AC39 HCT 116 C207(0.97); C217(0.97)  LDD0617  [1]
 LDCM0301  AC4 PaTu 8988t C207(1.31); C217(1.31)  LDD1180  [1]
 LDCM0302  AC40 HCT 116 C207(1.47); C217(1.47)  LDD0619  [1]
 LDCM0303  AC41 HCT 116 C207(2.13); C217(2.13)  LDD0620  [1]
 LDCM0304  AC42 HCT 116 C207(1.82); C217(1.82)  LDD0621  [1]
 LDCM0305  AC43 HCT 116 C207(1.92); C217(1.92)  LDD0622  [1]
 LDCM0306  AC44 HCT 116 C207(2.10); C217(2.10)  LDD0623  [1]
 LDCM0307  AC45 HCT 116 C207(1.84); C217(1.84)  LDD0624  [1]
 LDCM0308  AC46 HEK-293T C207(0.86); C217(0.79); C50(0.93)  LDD0906  [1]
 LDCM0309  AC47 HEK-293T C207(0.97); C217(1.02); C50(0.92)  LDD0907  [1]
 LDCM0310  AC48 HEK-293T C207(0.90); C217(0.83); C50(0.97)  LDD0908  [1]
 LDCM0311  AC49 HEK-293T C207(1.00); C217(1.07); C50(0.93)  LDD0909  [1]
 LDCM0312  AC5 PaTu 8988t C207(1.89); C217(1.89)  LDD1191  [1]
 LDCM0313  AC50 HEK-293T C207(0.97); C217(0.95); C50(1.00)  LDD0911  [1]
 LDCM0314  AC51 HEK-293T C207(0.94); C217(1.00); C50(0.88)  LDD0912  [1]
 LDCM0315  AC52 HEK-293T C207(1.16); C217(1.41); C50(0.92)  LDD0913  [1]
 LDCM0316  AC53 HEK-293T C207(1.12); C217(1.27); C50(0.97)  LDD0914  [1]
 LDCM0317  AC54 HEK-293T C207(0.99); C217(1.06); C50(0.93)  LDD0915  [1]
 LDCM0318  AC55 HEK-293T C207(0.97); C217(1.11); C50(0.82)  LDD0916  [1]
 LDCM0319  AC56 HEK-293T C207(0.79); C217(0.74); C50(0.83)  LDD0917  [1]
 LDCM0320  AC57 HEK-293T C207(0.78); C217(0.59); C50(0.97)  LDD0918  [1]
 LDCM0321  AC58 HEK-293T C207(0.81); C217(0.69); C50(0.93)  LDD0919  [1]
 LDCM0322  AC59 HEK-293T C207(0.64); C217(0.48); C50(0.80)  LDD0920  [1]
 LDCM0323  AC6 HEK-293T C207(0.85); C217(0.85)  LDD0921  [1]
 LDCM0324  AC60 HEK-293T C207(0.86); C217(0.79); C50(0.93)  LDD0922  [1]
 LDCM0325  AC61 HEK-293T C207(0.63); C217(0.49); C50(0.78)  LDD0923  [1]
 LDCM0326  AC62 HEK-293T C207(0.72); C217(0.62); C50(0.83)  LDD0924  [1]
 LDCM0327  AC63 HEK-293T C207(0.74); C217(0.67); C50(0.80)  LDD0925  [1]
 LDCM0328  AC64 HEK-293T C207(0.77); C217(0.70); C50(0.85)  LDD0926  [1]
 LDCM0329  AC65 HEK-293T C207(0.88); C217(0.92); C50(0.84)  LDD0927  [1]
 LDCM0330  AC66 HEK-293T C207(0.74); C217(0.65); C50(0.83)  LDD0928  [1]
 LDCM0331  AC67 HEK-293T C207(0.74); C217(0.64); C50(0.84)  LDD0929  [1]
 LDCM0332  AC68 HCT 116 C207(0.96); C217(0.96)  LDD0649  [1]
 LDCM0333  AC69 HCT 116 C207(0.92); C217(0.92)  LDD0650  [1]
 LDCM0334  AC7 HEK-293T C207(1.24); C217(1.24)  LDD0932  [1]
 LDCM0335  AC70 HCT 116 C207(0.79); C217(0.79)  LDD0652  [1]
 LDCM0336  AC71 HCT 116 C207(0.77); C217(0.77)  LDD0653  [1]
 LDCM0337  AC72 HCT 116 C207(0.94); C217(0.94)  LDD0654  [1]
 LDCM0338  AC73 HCT 116 C207(1.32); C217(1.32)  LDD0655  [1]
 LDCM0339  AC74 HCT 116 C207(1.22); C217(1.22)  LDD0656  [1]
 LDCM0340  AC75 HCT 116 C207(1.58); C217(1.58)  LDD0657  [1]
 LDCM0341  AC76 HCT 116 C207(0.97); C217(0.97)  LDD0658  [1]
 LDCM0342  AC77 HCT 116 C207(0.97); C217(0.97)  LDD0659  [1]
 LDCM0343  AC78 HCT 116 C207(0.78); C217(0.78)  LDD0660  [1]
 LDCM0344  AC79 HCT 116 C207(0.85); C217(0.85)  LDD0661  [1]
 LDCM0345  AC8 HEK-293T C207(1.01); C217(1.01)  LDD0943  [1]
 LDCM0346  AC80 HCT 116 C207(1.02); C217(1.02)  LDD0663  [1]
 LDCM0347  AC81 HCT 116 C207(0.82); C217(0.82)  LDD0664  [1]
 LDCM0348  AC82 HCT 116 C207(1.33); C217(1.33)  LDD0665  [1]
 LDCM0349  AC83 HEK-293T C207(0.96); C217(0.86); C50(1.07)  LDD0947  [1]
 LDCM0350  AC84 HEK-293T C207(0.98); C217(0.91); C50(1.06)  LDD0948  [1]
 LDCM0351  AC85 HEK-293T C207(0.97); C217(0.91); C50(1.03)  LDD0949  [1]
 LDCM0352  AC86 HEK-293T C207(1.03); C217(0.96); C50(1.11)  LDD0950  [1]
 LDCM0353  AC87 HEK-293T C207(1.04); C217(0.91); C50(1.17)  LDD0951  [1]
 LDCM0354  AC88 HEK-293T C207(0.92); C217(0.80); C50(1.04)  LDD0952  [1]
 LDCM0355  AC89 HEK-293T C207(0.95); C217(0.84); C50(1.07)  LDD0953  [1]
 LDCM0357  AC90 HEK-293T C207(1.01); C217(0.98); C50(1.04)  LDD0955  [1]
 LDCM0358  AC91 HEK-293T C207(0.82); C217(0.78); C50(0.85)  LDD0956  [1]
 LDCM0359  AC92 HEK-293T C207(0.94); C217(0.96); C50(0.92)  LDD0957  [1]
 LDCM0360  AC93 HEK-293T C207(1.01); C217(1.03); C50(0.98)  LDD0958  [1]
 LDCM0361  AC94 HEK-293T C207(0.88); C217(0.87); C50(0.90)  LDD0959  [1]
 LDCM0362  AC95 HEK-293T C207(1.05); C217(1.07); C50(1.03)  LDD0960  [1]
 LDCM0363  AC96 HEK-293T C207(0.99); C217(0.82); C50(1.17)  LDD0961  [1]
 LDCM0364  AC97 HEK-293T C207(0.86); C217(1.01); C50(0.71)  LDD0962  [1]
 LDCM0365  AC98 HEK-293T C207(0.90); C217(0.90)  LDD0963  [1]
 LDCM0366  AC99 HEK-293T C207(0.82); C217(0.82)  LDD0964  [1]
 LDCM0248  AKOS034007472 HEK-293T C207(1.69); C217(1.69)  LDD0846  [1]
 LDCM0356  AKOS034007680 HEK-293T C207(1.28); C217(1.28)  LDD0954  [1]
 LDCM0275  AKOS034007705 HEK-293T C207(1.56); C217(1.56)  LDD0873  [1]
 LDCM0020  ARS-1620 HCC44 C207(0.90); C217(0.90)  LDD0078  [1]
 LDCM0367  CL1 HEK-293T C207(0.98); C217(1.26); C50(0.71)  LDD0965  [1]
 LDCM0368  CL10 HEK-293T C207(0.93); C217(1.32); C50(0.53)  LDD0966  [1]
 LDCM0369  CL100 PaTu 8988t C207(1.65); C217(1.65)  LDD1248  [1]
 LDCM0370  CL101 HEK-293T C207(1.03); C217(1.03)  LDD0968  [1]
 LDCM0371  CL102 HEK-293T C207(2.03); C217(2.03)  LDD0969  [1]
 LDCM0372  CL103 HEK-293T C207(1.01); C217(1.01)  LDD0970  [1]
 LDCM0373  CL104 HEK-293T C207(0.67); C217(0.67)  LDD0971  [1]
 LDCM0374  CL105 HCT 116 C207(0.96); C217(0.96)  LDD0691  [1]
 LDCM0375  CL106 HCT 116 C207(0.81); C217(0.81)  LDD0692  [1]
 LDCM0376  CL107 HCT 116 C207(0.90); C217(0.90)  LDD0693  [1]
 LDCM0377  CL108 HCT 116 C207(0.77); C217(0.77)  LDD0694  [1]
 LDCM0378  CL109 HCT 116 C207(0.94); C217(0.94)  LDD0695  [1]
 LDCM0379  CL11 HEK-293T C207(0.70); C217(0.63); C50(0.77)  LDD0977  [1]
 LDCM0380  CL110 HCT 116 C207(0.88); C217(0.88)  LDD0697  [1]
 LDCM0381  CL111 HCT 116 C207(1.04); C217(1.04)  LDD0698  [1]
 LDCM0382  CL112 HEK-293T C207(0.75); C217(0.75)  LDD0980  [1]
 LDCM0383  CL113 HEK-293T C207(0.71); C217(0.71)  LDD0981  [1]
 LDCM0384  CL114 HEK-293T C207(0.63); C217(0.63)  LDD0982  [1]
 LDCM0385  CL115 HEK-293T C207(0.65); C217(0.65)  LDD0983  [1]
 LDCM0386  CL116 HEK-293T C207(0.56); C217(0.56)  LDD0984  [1]
 LDCM0387  CL117 HCT 116 C207(1.12); C217(1.12)  LDD0704  [1]
 LDCM0388  CL118 HCT 116 C207(0.90); C217(0.90)  LDD0705  [1]
 LDCM0389  CL119 HCT 116 C207(1.19); C217(1.19)  LDD0706  [1]
 LDCM0390  CL12 HEK-293T C207(1.07); C217(0.86); C50(1.29)  LDD0988  [1]
 LDCM0391  CL120 HCT 116 C207(1.57); C217(1.57)  LDD0708  [1]
 LDCM0392  CL121 HEK-293T C207(0.83); C217(0.83); C50(0.83)  LDD0990  [1]
 LDCM0393  CL122 HEK-293T C207(0.88); C217(0.87); C50(0.89)  LDD0991  [1]
 LDCM0394  CL123 HEK-293T C207(1.68); C217(2.34); C50(1.01)  LDD0992  [1]
 LDCM0395  CL124 HEK-293T C207(1.06); C217(1.10); C50(1.03)  LDD0993  [1]
 LDCM0396  CL125 HEK-293T C207(0.88); C217(0.91); C50(0.85)  LDD0994  [1]
 LDCM0397  CL126 HEK-293T C207(0.80); C217(0.86); C50(0.74)  LDD0995  [1]
 LDCM0398  CL127 HEK-293T C207(0.85); C217(0.83); C50(0.88)  LDD0996  [1]
 LDCM0399  CL128 HEK-293T C207(1.21); C217(1.47); C50(0.94)  LDD0997  [1]
 LDCM0400  CL13 HEK-293T C207(0.76); C217(0.58); C50(0.95)  LDD0998  [1]
 LDCM0401  CL14 HEK-293T C207(0.89); C217(0.83); C50(0.94)  LDD0999  [1]
 LDCM0402  CL15 HEK-293T C207(0.80); C217(0.97); C50(0.63)  LDD1000  [1]
 LDCM0403  CL16 HEK-293T C207(1.56); C217(1.56)  LDD1001  [1]
 LDCM0404  CL17 HEK-293T C207(1.29); C217(1.29)  LDD1002  [1]
 LDCM0405  CL18 HEK-293T C207(1.51); C217(1.51)  LDD1003  [1]
 LDCM0406  CL19 HEK-293T C207(1.73); C217(1.73)  LDD1004  [1]
 LDCM0407  CL2 HEK-293T C207(0.78); C217(0.74); C50(0.82)  LDD1005  [1]
 LDCM0408  CL20 HEK-293T C207(1.99); C217(1.99)  LDD1006  [1]
 LDCM0409  CL21 HEK-293T C207(2.92); C217(2.92)  LDD1007  [1]
 LDCM0410  CL22 HEK-293T C207(1.87); C217(1.87)  LDD1008  [1]
 LDCM0411  CL23 HEK-293T C207(1.54); C217(1.54)  LDD1009  [1]
 LDCM0412  CL24 HEK-293T C207(1.40); C217(1.40)  LDD1010  [1]
 LDCM0413  CL25 HEK-293T C207(1.41); C217(1.41)  LDD1011  [1]
 LDCM0414  CL26 HEK-293T C207(1.47); C217(1.47)  LDD1012  [1]
 LDCM0415  CL27 HEK-293T C207(1.31); C217(1.31)  LDD1013  [1]
 LDCM0416  CL28 HEK-293T C207(1.54); C217(1.54)  LDD1014  [1]
 LDCM0417  CL29 HEK-293T C207(1.78); C217(1.78)  LDD1015  [1]
 LDCM0418  CL3 HEK-293T C207(0.82); C217(0.67); C50(0.97)  LDD1016  [1]
 LDCM0419  CL30 HEK-293T C207(1.91); C217(1.91)  LDD1017  [1]
 LDCM0420  CL31 HEK-293T C207(1.00); C217(0.84); C50(1.33)  LDD1018  [1]
 LDCM0421  CL32 HEK-293T C207(1.09); C217(0.92); C50(1.47)  LDD1019  [1]
 LDCM0422  CL33 HEK-293T C207(0.90); C217(0.92); C50(0.94)  LDD1020  [1]
 LDCM0423  CL34 HEK-293T C207(0.98); C217(0.76); C50(1.44)  LDD1021  [1]
 LDCM0424  CL35 HEK-293T C207(1.07); C217(0.90); C50(1.34)  LDD1022  [1]
 LDCM0425  CL36 HEK-293T C207(1.06); C217(0.97); C50(1.31)  LDD1023  [1]
 LDCM0426  CL37 HEK-293T C207(1.07); C217(1.04); C50(1.15)  LDD1024  [1]
 LDCM0428  CL39 HEK-293T C207(0.95); C217(0.90); C50(0.93)  LDD1026  [1]
 LDCM0429  CL4 HEK-293T C207(0.96); C217(1.01); C50(0.90)  LDD1027  [1]
 LDCM0430  CL40 HEK-293T C207(1.11); C217(0.79); C50(1.87)  LDD1028  [1]
 LDCM0431  CL41 HEK-293T C207(1.30); C217(1.46); C50(1.19)  LDD1029  [1]
 LDCM0432  CL42 HEK-293T C207(1.08); C217(1.06); C50(1.02)  LDD1030  [1]
 LDCM0433  CL43 HEK-293T C207(0.96); C217(0.81); C50(1.14)  LDD1031  [1]
 LDCM0434  CL44 HEK-293T C207(1.17); C217(1.08); C50(1.33)  LDD1032  [1]
 LDCM0435  CL45 HEK-293T C207(0.89); C217(0.78); C50(0.99)  LDD1033  [1]
 LDCM0436  CL46 HCT 116 C207(1.18); C217(1.18)  LDD0753  [1]
 LDCM0437  CL47 HCT 116 C207(1.03); C217(1.03)  LDD0754  [1]
 LDCM0438  CL48 HCT 116 C207(1.01); C217(1.01)  LDD0755  [1]
 LDCM0439  CL49 HCT 116 C207(0.95); C217(0.95)  LDD0756  [1]
 LDCM0440  CL5 HEK-293T C207(0.83); C217(0.79); C50(0.88)  LDD1038  [1]
 LDCM0441  CL50 HCT 116 C207(1.11); C217(1.11)  LDD0758  [1]
 LDCM0442  CL51 HCT 116 C207(0.96); C217(0.96)  LDD0759  [1]
 LDCM0443  CL52 HCT 116 C207(1.34); C217(1.34)  LDD0760  [1]
 LDCM0444  CL53 HCT 116 C207(1.08); C217(1.08)  LDD0761  [1]
 LDCM0445  CL54 HCT 116 C207(1.53); C217(1.53)  LDD0762  [1]
 LDCM0446  CL55 HCT 116 C207(0.95); C217(0.95)  LDD0763  [1]
 LDCM0447  CL56 HCT 116 C207(0.90); C217(0.90)  LDD0764  [1]
 LDCM0448  CL57 HCT 116 C207(0.73); C217(0.73)  LDD0765  [1]
 LDCM0449  CL58 HCT 116 C207(0.90); C217(0.90)  LDD0766  [1]
 LDCM0450  CL59 HCT 116 C207(1.13); C217(1.13)  LDD0767  [1]
 LDCM0451  CL6 HEK-293T C207(1.05); C217(1.32); C50(0.79)  LDD1049  [1]
 LDCM0452  CL60 HCT 116 C207(1.12); C217(1.12)  LDD0769  [1]
 LDCM0453  CL61 HCT 116 C207(1.05); C217(1.05)  LDD0770  [1]
 LDCM0454  CL62 HCT 116 C207(1.06); C217(1.06)  LDD0771  [1]
 LDCM0455  CL63 HCT 116 C207(1.15); C217(1.15)  LDD0772  [1]
 LDCM0456  CL64 HCT 116 C207(1.30); C217(1.30)  LDD0773  [1]
 LDCM0457  CL65 HCT 116 C207(1.03); C217(1.03)  LDD0774  [1]
 LDCM0458  CL66 HCT 116 C207(1.42); C217(1.42)  LDD0775  [1]
 LDCM0459  CL67 HCT 116 C207(1.44); C217(1.44)  LDD0776  [1]
 LDCM0460  CL68 HCT 116 C207(1.02); C217(1.02)  LDD0777  [1]
 LDCM0461  CL69 HCT 116 C207(0.92); C217(0.92)  LDD0778  [1]
 LDCM0462  CL7 HEK-293T C207(0.71); C217(0.60); C50(0.82)  LDD1060  [1]
 LDCM0463  CL70 HCT 116 C207(1.02); C217(1.02)  LDD0780  [1]
 LDCM0464  CL71 HCT 116 C207(1.65); C217(1.65)  LDD0781  [1]
 LDCM0465  CL72 HCT 116 C207(1.05); C217(1.05)  LDD0782  [1]
 LDCM0466  CL73 HCT 116 C207(1.24); C217(1.24)  LDD0783  [1]
 LDCM0467  CL74 HCT 116 C207(1.19); C217(1.19)  LDD0784  [1]
 LDCM0469  CL76 HEK-293T C207(0.93); C217(0.93)  LDD1067  [1]
 LDCM0470  CL77 HEK-293T C207(1.19); C217(1.19)  LDD1068  [1]
 LDCM0471  CL78 HEK-293T C207(0.85); C217(0.85)  LDD1069  [1]
 LDCM0472  CL79 HEK-293T C207(1.18); C217(1.18)  LDD1070  [1]
 LDCM0473  CL8 HEK-293T C207(0.95)  LDD1071  [1]
 LDCM0474  CL80 HEK-293T C207(1.29); C217(1.29)  LDD1072  [1]
 LDCM0475  CL81 HEK-293T C207(0.90); C217(0.90)  LDD1073  [1]
 LDCM0476  CL82 HEK-293T C207(1.01); C217(1.01)  LDD1074  [1]
 LDCM0477  CL83 HEK-293T C207(1.02); C217(1.02)  LDD1075  [1]
 LDCM0478  CL84 HEK-293T C207(1.11); C217(1.11)  LDD1076  [1]
 LDCM0479  CL85 HEK-293T C207(1.11); C217(1.11)  LDD1077  [1]
 LDCM0480  CL86 HEK-293T C207(1.01); C217(1.01)  LDD1078  [1]
 LDCM0481  CL87 HEK-293T C207(0.90); C217(0.90)  LDD1079  [1]
 LDCM0482  CL88 HEK-293T C207(1.15); C217(1.15)  LDD1080  [1]
 LDCM0483  CL89 HEK-293T C207(0.97); C217(0.97)  LDD1081  [1]
 LDCM0484  CL9 HEK-293T C207(1.24)  LDD1082  [1]
 LDCM0485  CL90 HEK-293T C207(1.52); C217(1.52)  LDD1083  [1]
 LDCM0486  CL91 PaTu 8988t C207(1.25); C217(1.25)  LDD1365  [1]
 LDCM0487  CL92 PaTu 8988t C207(1.42); C217(1.42)  LDD1366  [1]
 LDCM0488  CL93 PaTu 8988t C207(1.29); C217(1.29)  LDD1367  [1]
 LDCM0489  CL94 PaTu 8988t C207(1.48); C217(1.48)  LDD1368  [1]
 LDCM0490  CL95 PaTu 8988t C207(2.60); C217(2.60)  LDD1369  [1]
 LDCM0491  CL96 PaTu 8988t C207(1.85); C217(1.85)  LDD1370  [1]
 LDCM0492  CL97 PaTu 8988t C207(1.69); C217(1.69)  LDD1371  [1]
 LDCM0493  CL98 PaTu 8988t C207(1.83); C217(1.83)  LDD1372  [1]
 LDCM0494  CL99 PaTu 8988t C207(1.39); C217(1.39)  LDD1373  [1]
 LDCM0495  E2913 HEK-293T C429(1.39)  LDD1698  [4]
 LDCM0468  Fragment33 HCT 116 C207(1.10); C217(1.10)  LDD0785  [1]
 LDCM0427  Fragment51 HEK-293T C207(1.23); C217(1.21); C50(1.41)  LDD1025  [1]
 LDCM0022  KB02 HCT 116 C207(1.98); C217(1.98)  LDD0080  [1]
 LDCM0023  KB03 HCT 116 C207(1.15); C217(1.15)  LDD0081  [1]
 LDCM0024  KB05 HCT 116 C207(1.49); C217(1.49)  LDD0082  [1]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Fibroblast growth factor receptor 3 (FGFR3) Tyr protein kinase family P22607
GTPase HRas (HRAS) Ras family P01112
Transcription factor
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Homeobox protein MOX-2 (MEOX2) . P50222
Other
Click To Hide/Show 3 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Centrosomal protein of 72 kDa (CEP72) CEP72 family Q9P209
Transforming acidic coiled-coil-containing protein 3 (TACC3) TACC family Q9Y6A5
Tuftelin-interacting protein 11 (TFIP11) TFP11/STIP family Q9UBB9

References

1 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
2 Benchmarking Cleavable Biotin Tags for Peptide-Centric Chemoproteomics. J Proteome Res. 2022 May 6;21(5):1349-1358. doi: 10.1021/acs.jproteome.2c00174. Epub 2022 Apr 25.
Mass spectrometry data entry: PXD031019
3 DFT-Guided Discovery of Ethynyl-Triazolyl-Phosphinates as Modular Electrophiles for Chemoselective Cysteine Bioconjugation and Profiling. Angew Chem Int Ed Engl. 2022 Oct 10;61(41):e202205348. doi: 10.1002/anie.202205348. Epub 2022 Aug 22.
Mass spectrometry data entry: PXD033004
4 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402