Details of the Target

General Information of Target

Target ID LDTP06642
Target Name Dual specificity protein phosphatase 7 (DUSP7)
Gene Name DUSP7
Gene ID 1849
Synonyms
PYST2; Dual specificity protein phosphatase 7; EC 3.1.3.16; EC 3.1.3.48; Dual specificity protein phosphatase PYST2
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MKNQLRGPPARAHMSTSGAAAAGGTRAGSEPGAGSGSGAGTGAGAATGAGAMPCKSAEWL
QEELEARGGASLLLLDCRPHELFESSHIETAINLAIPGLMLRRLRKGNLPIRSIIPNHAD
KERFATRCKAATVLLYDEATAEWQPEPGAPASVLGLLLQKLRDDGCQAYYLQGGFNKFQT
EYSEHCETNVDSSSSPSSSPPTSVLGLGGLRISSDCSDGESDRELPSSATESDGSPVPSS
QPAFPVQILPYLYLGCAKDSTNLDVLGKYGIKYILNVTPNLPNAFEHGGEFTYKQIPISD
HWSQNLSQFFPEAISFIDEARSKKCGVLVHCLAGISRSVTVTVAYLMQKMNLSLNDAYDF
VKRKKSNISPNFNFMGQLLDFERTLGLSSPCDNHASSEQLYFSTPTNHNLFPLNTLEST
Target Bioclass
Enzyme
Family
Protein-tyrosine phosphatase family, Non-receptor class dual specificity subfamily
Subcellular location
Cytoplasm
Function
Dual specificity protein phosphatase. Shows high activity towards MAPK1/ERK2. Also has lower activity towards MAPK14 and MAPK8. In arrested oocytes, plays a role in meiotic resumption. Promotes nuclear envelope breakdown and activation of the CDK1/Cyclin-B complex in oocytes, probably by dephosphorylating and inactivating the conventional protein kinase C (cPKC) isozyme PRKCB. May also inactivate PRKCA and/or PRKCG. Also important in oocytes for normal chromosome alignment on the metaphase plate and progression to anaphase, where it might regulate activity of the spindle-assembly checkpoint (SAC) complex.
Uniprot ID
Q16829
Ensemble ID
ENST00000495880.2
HGNC ID
HGNC:3073

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
769P Deletion: p.N283TfsTer57 .
HCT15 SNV: p.W59Ter .
Ishikawa (Heraklio) 02 ER SNV: p.M100L .
JURKAT SNV: p.A333V .
LNCaP clone FGC Deletion: p.G209AfsTer131 .
MOLT4 SNV: p.R102C; p.T340M .
NCIH1793 SNV: p.P390L .
OVCAR5 SNV: p.K55E .
P31FUJ SNV: p.A141D .
SUPT1 SNV: p.Q167R .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 3 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
STPyne
 Probe Info  		K160(5.88)  LDD0277  [1]
DBIA
 Probe Info  		C166(0.87)  LDD0547  [2]
IPM
 Probe Info  		C54(0.00); C216(0.00)  LDD2156  [3]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HEK-293T C166(0.39)  LDD0812  [2]
 LDCM0215  AC10 HEK-293T C166(0.37)  LDD0813  [2]
 LDCM0216  AC100 HEK-293T C166(0.80)  LDD0814  [2]
 LDCM0217  AC101 HEK-293T C166(0.63)  LDD0815  [2]
 LDCM0218  AC102 HEK-293T C166(0.60)  LDD0816  [2]
 LDCM0219  AC103 HEK-293T C166(0.86)  LDD0817  [2]
 LDCM0220  AC104 HEK-293T C166(1.09)  LDD0818  [2]
 LDCM0221  AC105 HEK-293T C166(0.60)  LDD0819  [2]
 LDCM0222  AC106 HEK-293T C166(0.53)  LDD0820  [2]
 LDCM0223  AC107 HEK-293T C166(0.63)  LDD0821  [2]
 LDCM0224  AC108 HEK-293T C166(0.69)  LDD0822  [2]
 LDCM0225  AC109 HEK-293T C166(0.77)  LDD0823  [2]
 LDCM0226  AC11 HEK-293T C166(0.40)  LDD0824  [2]
 LDCM0227  AC110 HEK-293T C166(0.53)  LDD0825  [2]
 LDCM0228  AC111 HEK-293T C166(0.73)  LDD0826  [2]
 LDCM0229  AC112 HEK-293T C166(0.80)  LDD0827  [2]
 LDCM0230  AC113 HCT 116 C166(0.87)  LDD0547  [2]
 LDCM0231  AC114 HCT 116 C166(0.89)  LDD0548  [2]
 LDCM0232  AC115 HCT 116 C166(0.78)  LDD0549  [2]
 LDCM0233  AC116 HCT 116 C166(1.00)  LDD0550  [2]
 LDCM0234  AC117 HCT 116 C166(0.76)  LDD0551  [2]
 LDCM0235  AC118 HCT 116 C166(0.89)  LDD0552  [2]
 LDCM0236  AC119 HCT 116 C166(0.86)  LDD0553  [2]
 LDCM0237  AC12 HEK-293T C166(0.86)  LDD0835  [2]
 LDCM0238  AC120 HCT 116 C166(0.75)  LDD0555  [2]
 LDCM0239  AC121 HCT 116 C166(0.86)  LDD0556  [2]
 LDCM0240  AC122 HCT 116 C166(0.71)  LDD0557  [2]
 LDCM0241  AC123 HCT 116 C166(0.78)  LDD0558  [2]
 LDCM0242  AC124 HCT 116 C166(0.65)  LDD0559  [2]
 LDCM0243  AC125 HCT 116 C166(0.96)  LDD0560  [2]
 LDCM0244  AC126 HCT 116 C166(1.00)  LDD0561  [2]
 LDCM0245  AC127 HCT 116 C166(0.71)  LDD0562  [2]
 LDCM0246  AC128 HEK-293T C166(1.19)  LDD0844  [2]
 LDCM0247  AC129 HEK-293T C166(1.26)  LDD0845  [2]
 LDCM0249  AC130 HEK-293T C166(2.11)  LDD0847  [2]
 LDCM0250  AC131 HEK-293T C166(1.62)  LDD0848  [2]
 LDCM0251  AC132 HEK-293T C166(1.30)  LDD0849  [2]
 LDCM0252  AC133 HEK-293T C166(1.65)  LDD0850  [2]
 LDCM0253  AC134 HEK-293T C166(1.88)  LDD0851  [2]
 LDCM0254  AC135 HEK-293T C166(1.23)  LDD0852  [2]
 LDCM0255  AC136 HEK-293T C166(0.78)  LDD0853  [2]
 LDCM0256  AC137 HEK-293T C166(1.13)  LDD0854  [2]
 LDCM0257  AC138 HEK-293T C166(1.81)  LDD0855  [2]
 LDCM0258  AC139 HEK-293T C166(1.50)  LDD0856  [2]
 LDCM0259  AC14 HEK-293T C166(0.68)  LDD0857  [2]
 LDCM0260  AC140 HEK-293T C166(1.30)  LDD0858  [2]
 LDCM0261  AC141 HEK-293T C166(1.08)  LDD0859  [2]
 LDCM0262  AC142 HEK-293T C166(1.34)  LDD0860  [2]
 LDCM0270  AC15 HEK-293T C166(0.51)  LDD0868  [2]
 LDCM0276  AC17 PaTu 8988t C166(1.14)  LDD1155  [2]
 LDCM0277  AC18 PaTu 8988t C166(1.55)  LDD1156  [2]
 LDCM0278  AC19 PaTu 8988t C166(1.00)  LDD1157  [2]
 LDCM0279  AC2 HEK-293T C166(0.63)  LDD0877  [2]
 LDCM0280  AC20 PaTu 8988t C166(0.92)  LDD1159  [2]
 LDCM0281  AC21 PaTu 8988t C166(1.27)  LDD1160  [2]
 LDCM0282  AC22 PaTu 8988t C166(1.16)  LDD1161  [2]
 LDCM0283  AC23 PaTu 8988t C166(1.31)  LDD1162  [2]
 LDCM0284  AC24 PaTu 8988t C166(1.08)  LDD1163  [2]
 LDCM0286  AC26 HEK-293T C77(0.86)  LDD1525  [4]
 LDCM0290  AC3 HEK-293T C166(0.43)  LDD0888  [2]
 LDCM0291  AC30 HEK-293T C77(1.25)  LDD1530  [4]
 LDCM0295  AC34 HEK-293T C77(0.86)  LDD1534  [4]
 LDCM0296  AC35 HEK-293T C166(1.08)  LDD0894  [2]
 LDCM0297  AC36 HEK-293T C166(1.56)  LDD0895  [2]
 LDCM0298  AC37 HEK-293T C166(1.14)  LDD0896  [2]
 LDCM0299  AC38 HEK-293T C166(0.99)  LDD0897  [2]
 LDCM0300  AC39 HEK-293T C166(0.89)  LDD0898  [2]
 LDCM0301  AC4 HEK-293T C166(0.45)  LDD0899  [2]
 LDCM0302  AC40 HEK-293T C166(1.36)  LDD0900  [2]
 LDCM0303  AC41 HEK-293T C166(0.86)  LDD0901  [2]
 LDCM0304  AC42 HEK-293T C166(1.04)  LDD0902  [2]
 LDCM0305  AC43 HEK-293T C166(1.06)  LDD0903  [2]
 LDCM0306  AC44 HEK-293T C166(0.93)  LDD0904  [2]
 LDCM0307  AC45 HEK-293T C166(0.83)  LDD0905  [2]
 LDCM0308  AC46 HCT 116 C166(1.00)  LDD0625  [2]
 LDCM0309  AC47 HCT 116 C166(1.65)  LDD0626  [2]
 LDCM0310  AC48 HCT 116 C166(1.01)  LDD0627  [2]
 LDCM0311  AC49 HCT 116 C166(1.20)  LDD0628  [2]
 LDCM0312  AC5 HEK-293T C166(0.68)  LDD0910  [2]
 LDCM0313  AC50 HCT 116 C166(1.66)  LDD0630  [2]
 LDCM0314  AC51 HCT 116 C166(1.22)  LDD0631  [2]
 LDCM0315  AC52 HCT 116 C166(1.25)  LDD0632  [2]
 LDCM0316  AC53 HCT 116 C166(1.56)  LDD0633  [2]
 LDCM0317  AC54 HCT 116 C166(1.42)  LDD0634  [2]
 LDCM0318  AC55 HCT 116 C166(1.25)  LDD0635  [2]
 LDCM0319  AC56 HCT 116 C166(1.74)  LDD0636  [2]
 LDCM0320  AC57 HEK-293T C166(1.27)  LDD0918  [2]
 LDCM0321  AC58 HEK-293T C166(0.84)  LDD0919  [2]
 LDCM0322  AC59 HEK-293T C166(1.06)  LDD0920  [2]
 LDCM0323  AC6 HEK-293T C166(0.78)  LDD0921  [2]
 LDCM0324  AC60 HEK-293T C166(1.43)  LDD0922  [2]
 LDCM0325  AC61 HEK-293T C166(1.33)  LDD0923  [2]
 LDCM0326  AC62 HEK-293T C166(1.04)  LDD0924  [2]
 LDCM0327  AC63 HEK-293T C166(1.12)  LDD0925  [2]
 LDCM0328  AC64 HEK-293T C166(1.07)  LDD0926  [2]
 LDCM0329  AC65 HEK-293T C166(1.07)  LDD0927  [2]
 LDCM0330  AC66 HEK-293T C166(1.08)  LDD0928  [2]
 LDCM0331  AC67 HEK-293T C166(1.13)  LDD0929  [2]
 LDCM0332  AC68 HEK-293T C166(1.17)  LDD0930  [2]
 LDCM0333  AC69 HEK-293T C166(1.01)  LDD0931  [2]
 LDCM0334  AC7 HEK-293T C166(0.71)  LDD0932  [2]
 LDCM0335  AC70 HEK-293T C166(1.17)  LDD0933  [2]
 LDCM0336  AC71 HEK-293T C166(1.27)  LDD0934  [2]
 LDCM0337  AC72 HEK-293T C166(1.21)  LDD0935  [2]
 LDCM0338  AC73 HEK-293T C166(1.67)  LDD0936  [2]
 LDCM0339  AC74 HEK-293T C166(1.32)  LDD0937  [2]
 LDCM0340  AC75 HEK-293T C166(1.71)  LDD0938  [2]
 LDCM0341  AC76 HEK-293T C166(1.33)  LDD0939  [2]
 LDCM0342  AC77 HEK-293T C166(0.92)  LDD0940  [2]
 LDCM0343  AC78 HEK-293T C166(1.29)  LDD0941  [2]
 LDCM0344  AC79 HEK-293T C166(1.35)  LDD0942  [2]
 LDCM0345  AC8 HEK-293T C166(1.06)  LDD0943  [2]
 LDCM0346  AC80 HEK-293T C166(1.91)  LDD0944  [2]
 LDCM0347  AC81 HEK-293T C166(1.73)  LDD0945  [2]
 LDCM0348  AC82 HEK-293T C166(1.12)  LDD0946  [2]
 LDCM0349  AC83 HCT 116 C166(0.78)  LDD0666  [2]
 LDCM0350  AC84 HCT 116 C166(0.82)  LDD0667  [2]
 LDCM0351  AC85 HCT 116 C166(0.69)  LDD0668  [2]
 LDCM0352  AC86 HCT 116 C166(0.64)  LDD0669  [2]
 LDCM0353  AC87 HCT 116 C166(0.74)  LDD0670  [2]
 LDCM0354  AC88 HCT 116 C166(0.62)  LDD0671  [2]
 LDCM0355  AC89 HCT 116 C166(0.75)  LDD0672  [2]
 LDCM0357  AC90 HCT 116 C166(0.58)  LDD0674  [2]
 LDCM0358  AC91 HCT 116 C166(0.61)  LDD0675  [2]
 LDCM0359  AC92 HCT 116 C166(0.54)  LDD0676  [2]
 LDCM0360  AC93 HCT 116 C166(0.58)  LDD0677  [2]
 LDCM0361  AC94 HCT 116 C166(0.62)  LDD0678  [2]
 LDCM0362  AC95 HCT 116 C166(0.54)  LDD0679  [2]
 LDCM0363  AC96 HCT 116 C166(0.62)  LDD0680  [2]
 LDCM0364  AC97 HCT 116 C166(0.63)  LDD0681  [2]
 LDCM0365  AC98 HEK-293T C166(0.76)  LDD0963  [2]
 LDCM0366  AC99 HEK-293T C166(0.82)  LDD0964  [2]
 LDCM0248  AKOS034007472 HEK-293T C166(0.73)  LDD0846  [2]
 LDCM0356  AKOS034007680 HEK-293T C166(0.47)  LDD0954  [2]
 LDCM0275  AKOS034007705 HEK-293T C166(0.70)  LDD0873  [2]
 LDCM0367  CL1 HEK-293T C166(1.24)  LDD0965  [2]
 LDCM0368  CL10 HEK-293T C166(0.84)  LDD0966  [2]
 LDCM0369  CL100 HEK-293T C166(0.80)  LDD0967  [2]
 LDCM0370  CL101 HEK-293T C166(1.94)  LDD0968  [2]
 LDCM0371  CL102 HEK-293T C166(0.77)  LDD0969  [2]
 LDCM0372  CL103 HEK-293T C166(1.64)  LDD0970  [2]
 LDCM0373  CL104 HEK-293T C166(0.61)  LDD0971  [2]
 LDCM0374  CL105 PaTu 8988t C166(0.95)  LDD1253  [2]
 LDCM0375  CL106 PaTu 8988t C166(1.06)  LDD1254  [2]
 LDCM0376  CL107 PaTu 8988t C166(0.78)  LDD1255  [2]
 LDCM0377  CL108 PaTu 8988t C166(0.93)  LDD1256  [2]
 LDCM0378  CL109 PaTu 8988t C166(0.88)  LDD1257  [2]
 LDCM0379  CL11 HEK-293T C166(0.94)  LDD0977  [2]
 LDCM0380  CL110 PaTu 8988t C166(0.99)  LDD1259  [2]
 LDCM0381  CL111 PaTu 8988t C166(1.10)  LDD1260  [2]
 LDCM0382  CL112 HEK-293T C77(1.13)  LDD1586  [4]
 LDCM0384  CL114 HEK-293T C77(1.46)  LDD1588  [4]
 LDCM0386  CL116 HEK-293T C77(0.83)  LDD1590  [4]
 LDCM0387  CL117 HEK-293T C166(1.04)  LDD0985  [2]
 LDCM0388  CL118 HEK-293T C166(1.00)  LDD0986  [2]
 LDCM0389  CL119 HEK-293T C166(0.92)  LDD0987  [2]
 LDCM0390  CL12 HEK-293T C166(1.18)  LDD0988  [2]
 LDCM0391  CL120 HEK-293T C166(0.86)  LDD0989  [2]
 LDCM0392  CL121 HCT 116 C166(1.34)  LDD0709  [2]
 LDCM0393  CL122 HCT 116 C166(1.32)  LDD0710  [2]
 LDCM0394  CL123 HCT 116 C166(1.26)  LDD0711  [2]
 LDCM0395  CL124 HCT 116 C166(1.41)  LDD0712  [2]
 LDCM0396  CL125 HEK-293T C166(1.19)  LDD0994  [2]
 LDCM0397  CL126 HEK-293T C166(1.21)  LDD0995  [2]
 LDCM0398  CL127 HEK-293T C166(1.27)  LDD0996  [2]
 LDCM0399  CL128 HEK-293T C166(0.97)  LDD0997  [2]
 LDCM0400  CL13 HEK-293T C166(0.88)  LDD0998  [2]
 LDCM0401  CL14 HEK-293T C166(1.32)  LDD0999  [2]
 LDCM0402  CL15 HEK-293T C166(1.26)  LDD1000  [2]
 LDCM0403  CL16 HEK-293T C166(1.11)  LDD1001  [2]
 LDCM0404  CL17 HCT 116 C166(0.83)  LDD0721  [2]
 LDCM0405  CL18 HCT 116 C166(0.81)  LDD0722  [2]
 LDCM0406  CL19 HCT 116 C166(0.86)  LDD0723  [2]
 LDCM0407  CL2 HEK-293T C166(0.82)  LDD1005  [2]
 LDCM0408  CL20 HCT 116 C166(0.85)  LDD0725  [2]
 LDCM0409  CL21 HCT 116 C166(0.98)  LDD0726  [2]
 LDCM0410  CL22 HCT 116 C166(1.15)  LDD0727  [2]
 LDCM0411  CL23 HCT 116 C166(0.74)  LDD0728  [2]
 LDCM0412  CL24 HCT 116 C166(0.87)  LDD0729  [2]
 LDCM0413  CL25 HCT 116 C166(1.06)  LDD0730  [2]
 LDCM0414  CL26 HCT 116 C166(0.98)  LDD0731  [2]
 LDCM0415  CL27 HCT 116 C166(0.88)  LDD0732  [2]
 LDCM0416  CL28 HCT 116 C166(0.89)  LDD0733  [2]
 LDCM0417  CL29 HCT 116 C166(0.97)  LDD0734  [2]
 LDCM0418  CL3 HEK-293T C166(0.99)  LDD1016  [2]
 LDCM0419  CL30 HCT 116 C166(0.67)  LDD0736  [2]
 LDCM0420  CL31 HCT 116 C166(0.88)  LDD0737  [2]
 LDCM0421  CL32 PaTu 8988t C166(1.32)  LDD1300  [2]
 LDCM0422  CL33 PaTu 8988t C166(1.33)  LDD1301  [2]
 LDCM0423  CL34 PaTu 8988t C166(1.20)  LDD1302  [2]
 LDCM0424  CL35 PaTu 8988t C166(0.72)  LDD1303  [2]
 LDCM0425  CL36 PaTu 8988t C166(1.10)  LDD1304  [2]
 LDCM0426  CL37 PaTu 8988t C166(1.22)  LDD1305  [2]
 LDCM0428  CL39 PaTu 8988t C166(0.92)  LDD1307  [2]
 LDCM0429  CL4 HEK-293T C166(1.12)  LDD1027  [2]
 LDCM0430  CL40 PaTu 8988t C166(0.85)  LDD1309  [2]
 LDCM0431  CL41 PaTu 8988t C166(1.31)  LDD1310  [2]
 LDCM0432  CL42 PaTu 8988t C166(1.42)  LDD1311  [2]
 LDCM0433  CL43 PaTu 8988t C166(1.21)  LDD1312  [2]
 LDCM0434  CL44 PaTu 8988t C166(1.23)  LDD1313  [2]
 LDCM0435  CL45 PaTu 8988t C166(1.23)  LDD1314  [2]
 LDCM0436  CL46 HEK-293T C166(0.99)  LDD1034  [2]
 LDCM0437  CL47 HEK-293T C166(1.02)  LDD1035  [2]
 LDCM0438  CL48 HEK-293T C166(1.01)  LDD1036  [2]
 LDCM0439  CL49 HEK-293T C166(1.07)  LDD1037  [2]
 LDCM0440  CL5 HEK-293T C166(0.84)  LDD1038  [2]
 LDCM0441  CL50 HEK-293T C166(1.10)  LDD1039  [2]
 LDCM0442  CL51 HEK-293T C166(1.15)  LDD1040  [2]
 LDCM0443  CL52 HEK-293T C166(1.45)  LDD1041  [2]
 LDCM0444  CL53 HEK-293T C166(1.32)  LDD1042  [2]
 LDCM0445  CL54 HEK-293T C166(1.69)  LDD1043  [2]
 LDCM0446  CL55 HEK-293T C166(1.11)  LDD1044  [2]
 LDCM0447  CL56 HEK-293T C166(1.14)  LDD1045  [2]
 LDCM0448  CL57 HEK-293T C166(1.27)  LDD1046  [2]
 LDCM0449  CL58 HEK-293T C166(0.91)  LDD1047  [2]
 LDCM0450  CL59 HEK-293T C166(1.08)  LDD1048  [2]
 LDCM0451  CL6 HEK-293T C166(1.06)  LDD1049  [2]
 LDCM0452  CL60 HEK-293T C166(0.95)  LDD1050  [2]
 LDCM0453  CL61 HEK-293T C166(0.92)  LDD1051  [2]
 LDCM0454  CL62 HEK-293T C166(1.04)  LDD1052  [2]
 LDCM0455  CL63 HEK-293T C166(1.01)  LDD1053  [2]
 LDCM0456  CL64 HEK-293T C166(1.48)  LDD1054  [2]
 LDCM0457  CL65 HEK-293T C166(0.82)  LDD1055  [2]
 LDCM0458  CL66 HEK-293T C166(1.08)  LDD1056  [2]
 LDCM0459  CL67 HEK-293T C166(0.89)  LDD1057  [2]
 LDCM0460  CL68 HEK-293T C166(0.72)  LDD1058  [2]
 LDCM0461  CL69 HEK-293T C166(0.87)  LDD1059  [2]
 LDCM0462  CL7 HEK-293T C166(0.83)  LDD1060  [2]
 LDCM0463  CL70 HEK-293T C166(0.80)  LDD1061  [2]
 LDCM0464  CL71 HEK-293T C166(0.93)  LDD1062  [2]
 LDCM0465  CL72 HEK-293T C166(1.09)  LDD1063  [2]
 LDCM0466  CL73 HEK-293T C166(1.03)  LDD1064  [2]
 LDCM0467  CL74 HEK-293T C166(1.02)  LDD1065  [2]
 LDCM0469  CL76 PaTu 8988t C166(0.88)  LDD1348  [2]
 LDCM0470  CL77 PaTu 8988t C166(1.02)  LDD1349  [2]
 LDCM0471  CL78 PaTu 8988t C166(0.96)  LDD1350  [2]
 LDCM0472  CL79 PaTu 8988t C166(0.98)  LDD1351  [2]
 LDCM0473  CL8 HEK-293T C166(0.95)  LDD1071  [2]
 LDCM0474  CL80 PaTu 8988t C166(1.04)  LDD1353  [2]
 LDCM0475  CL81 PaTu 8988t C166(0.91)  LDD1354  [2]
 LDCM0476  CL82 PaTu 8988t C166(0.91)  LDD1355  [2]
 LDCM0477  CL83 PaTu 8988t C166(0.90)  LDD1356  [2]
 LDCM0478  CL84 PaTu 8988t C166(0.87)  LDD1357  [2]
 LDCM0479  CL85 PaTu 8988t C166(0.94)  LDD1358  [2]
 LDCM0480  CL86 PaTu 8988t C166(1.18)  LDD1359  [2]
 LDCM0481  CL87 PaTu 8988t C166(1.05)  LDD1360  [2]
 LDCM0482  CL88 PaTu 8988t C166(1.11)  LDD1361  [2]
 LDCM0483  CL89 PaTu 8988t C166(1.01)  LDD1362  [2]
 LDCM0484  CL9 HEK-293T C166(0.91)  LDD1082  [2]
 LDCM0485  CL90 PaTu 8988t C166(1.06)  LDD1364  [2]
 LDCM0486  CL91 HEK-293T C166(0.46)  LDD1084  [2]
 LDCM0487  CL92 HEK-293T C166(0.54)  LDD1085  [2]
 LDCM0488  CL93 HEK-293T C166(0.76)  LDD1086  [2]
 LDCM0489  CL94 HEK-293T C166(0.91)  LDD1087  [2]
 LDCM0490  CL95 HEK-293T C166(1.21)  LDD1088  [2]
 LDCM0491  CL96 HEK-293T C166(0.68)  LDD1089  [2]
 LDCM0492  CL97 HEK-293T C166(0.56)  LDD1090  [2]
 LDCM0493  CL98 HEK-293T C166(0.40)  LDD1091  [2]
 LDCM0494  CL99 HEK-293T C166(0.33)  LDD1092  [2]
 LDCM0468  Fragment33 HEK-293T C166(1.22)  LDD1066  [2]
 LDCM0427  Fragment51 PaTu 8988t C166(1.27)  LDD1306  [2]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Speckle-type POZ protein (SPOP) Tdpoz family O43791
Prolyl hydroxylase EGLN3 (EGLN3) . Q9H6Z9
Cytokine and receptor
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Growth hormone receptor (GHR) Type I cytokine receptor family P10912

References

1 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
2 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
3 Benchmarking Cleavable Biotin Tags for Peptide-Centric Chemoproteomics. J Proteome Res. 2022 May 6;21(5):1349-1358. doi: 10.1021/acs.jproteome.2c00174. Epub 2022 Apr 25.
Mass spectrometry data entry: PXD031019
4 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402