Details of the Target

General Information of Target

Target ID LDTP06410
Target Name Transcription initiation factor TFIID subunit 7 (TAF7)
Gene Name TAF7
Gene ID 6879
Synonyms
TAF2F; TAFII55; Transcription initiation factor TFIID subunit 7; RNA polymerase II TBP-associated factor subunit F; Transcription initiation factor TFIID 55 kDa subunit; TAF(II)55; TAFII-55; TAFII55
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MSKSKDDAPHELESQFILRLPPEYASTVRRAVQSGHVNLKDRLTIELHPDGRHGIVRVDR
VPLASKLVDLPCVMESLKTIDKKTFYKTADICQMLVSTVDGDLYPPVEEPVASTDPKASK
KKDKDKEKKFIWNHGITLPLKNVRKRRFRKTAKKKYIESPDVEKEVKRLLSTDAEAVSTR
WEIIAEDETKEAENQGLDISSPGMSGHRQGHDSLEHDELREIFNDLSSSSEDEDETQHQD
EEDINIIDTEEDLERQLQDKLNESDEQHQENEGTNQLVMGIQKQIDNMKGKLQETQDRAK
RQEDLIMKVENLALKNRFQAVLDELKQKEDREKEQLSSLQEELESLLEK
Target Bioclass
Other
Family
TAF7 family
Subcellular location
Nucleus
Function
The TFIID basal transcription factor complex plays a major role in the initiation of RNA polymerase II (Pol II)-dependent transcription. TFIID recognizes and binds promoters with or without a TATA box via its subunit TBP, a TATA-box-binding protein, and promotes assembly of the pre-initiation complex (PIC). The TFIID complex consists of TBP and TBP-associated factors (TAFs), including TAF1, TAF2, TAF3, TAF4, TAF5, TAF6, TAF7, TAF8, TAF9, TAF10, TAF11, TAF12 and TAF13. TAF7 forms a promoter DNA binding subcomplex of TFIID, together with TAF1 and TAF2. Part of a TFIID complex containing TAF10 (TFIID alpha) and a TFIID complex lacking TAF10 (TFIID beta).
Uniprot ID
Q15545
Ensemble ID
ENST00000313368.8
HGNC ID
HGNC:11541

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 14 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
STPyne
 Probe Info  		K66(7.69)  LDD0277  [1]
m-APA
 Probe Info  		14.96  LDD0403  [2]
DBIA
 Probe Info  		C72(2.57)  LDD3339  [3]
BTD
 Probe Info  		C72(0.96)  LDD2100  [4]
IPM
 Probe Info  		C72(1.23)  LDD1701  [4]
Acrolein
 Probe Info  		N.A.  LDD0223  [5]
ATP probe
 Probe Info  		N.A.  LDD0199  [6]
IA-alkyne
 Probe Info  		N.A.  LDD0162  [7]
NAIA_4
 Probe Info  		N.A.  LDD2226  [8]
WYneN
 Probe Info  		N.A.  LDD0021  [9]
PF-06672131
 Probe Info  		N.A.  LDD0017  [10]
Phosphinate-6
 Probe Info  		N.A.  LDD0018  [11]
AOyne
 Probe Info  		15.00  LDD0443  [12]
NAIA_5
 Probe Info  		N.A.  LDD2223  [8]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HEK-293T C72(1.15)  LDD1507  [13]
 LDCM0215  AC10 HEK-293T C72(1.17)  LDD1508  [13]
 LDCM0216  AC100 PaTu 8988t C72(1.15)  LDD1095  [14]
 LDCM0217  AC101 PaTu 8988t C72(1.05)  LDD1096  [14]
 LDCM0218  AC102 PaTu 8988t C72(1.03)  LDD1097  [14]
 LDCM0219  AC103 PaTu 8988t C72(1.09)  LDD1098  [14]
 LDCM0220  AC104 PaTu 8988t C72(1.01)  LDD1099  [14]
 LDCM0221  AC105 PaTu 8988t C72(1.04)  LDD1100  [14]
 LDCM0222  AC106 PaTu 8988t C72(1.10)  LDD1101  [14]
 LDCM0223  AC107 PaTu 8988t C72(0.89)  LDD1102  [14]
 LDCM0224  AC108 PaTu 8988t C72(1.12)  LDD1103  [14]
 LDCM0225  AC109 PaTu 8988t C72(1.23)  LDD1104  [14]
 LDCM0226  AC11 HEK-293T C72(1.07); C92(0.98)  LDD1509  [13]
 LDCM0227  AC110 PaTu 8988t C72(1.25)  LDD1106  [14]
 LDCM0228  AC111 PaTu 8988t C72(1.31)  LDD1107  [14]
 LDCM0229  AC112 PaTu 8988t C72(1.13)  LDD1108  [14]
 LDCM0230  AC113 PaTu 8988t C72(0.77)  LDD1109  [14]
 LDCM0231  AC114 PaTu 8988t C72(0.94)  LDD1110  [14]
 LDCM0232  AC115 PaTu 8988t C72(0.85)  LDD1111  [14]
 LDCM0233  AC116 PaTu 8988t C72(1.03)  LDD1112  [14]
 LDCM0234  AC117 PaTu 8988t C72(0.86)  LDD1113  [14]
 LDCM0235  AC118 PaTu 8988t C72(0.91)  LDD1114  [14]
 LDCM0236  AC119 PaTu 8988t C72(0.99)  LDD1115  [14]
 LDCM0237  AC12 HEK-293T C92(0.96)  LDD1510  [13]
 LDCM0238  AC120 PaTu 8988t C72(0.85)  LDD1117  [14]
 LDCM0239  AC121 PaTu 8988t C72(1.00)  LDD1118  [14]
 LDCM0240  AC122 PaTu 8988t C72(0.89)  LDD1119  [14]
 LDCM0241  AC123 PaTu 8988t C72(0.78)  LDD1120  [14]
 LDCM0242  AC124 PaTu 8988t C72(1.11)  LDD1121  [14]
 LDCM0243  AC125 PaTu 8988t C72(0.83)  LDD1122  [14]
 LDCM0244  AC126 PaTu 8988t C72(0.83)  LDD1123  [14]
 LDCM0245  AC127 PaTu 8988t C72(1.11)  LDD1124  [14]
 LDCM0259  AC14 HEK-293T C72(1.03); C92(1.09)  LDD1512  [13]
 LDCM0263  AC143 PaTu 8988t C72(1.04)  LDD1142  [14]
 LDCM0264  AC144 PaTu 8988t C72(0.95)  LDD1143  [14]
 LDCM0265  AC145 PaTu 8988t C72(1.02)  LDD1144  [14]
 LDCM0266  AC146 PaTu 8988t C72(0.89)  LDD1145  [14]
 LDCM0267  AC147 PaTu 8988t C72(0.90)  LDD1146  [14]
 LDCM0268  AC148 PaTu 8988t C72(1.18)  LDD1147  [14]
 LDCM0269  AC149 PaTu 8988t C72(1.16)  LDD1148  [14]
 LDCM0270  AC15 HEK-293T C72(1.00)  LDD1513  [13]
 LDCM0271  AC150 PaTu 8988t C72(0.93)  LDD1150  [14]
 LDCM0272  AC151 PaTu 8988t C72(1.02)  LDD1151  [14]
 LDCM0273  AC152 PaTu 8988t C72(0.97)  LDD1152  [14]
 LDCM0274  AC153 PaTu 8988t C72(1.12)  LDD1153  [14]
 LDCM0621  AC154 PaTu 8988t C72(0.98)  LDD2166  [14]
 LDCM0622  AC155 PaTu 8988t C72(0.98)  LDD2167  [14]
 LDCM0623  AC156 PaTu 8988t C72(1.03)  LDD2168  [14]
 LDCM0624  AC157 PaTu 8988t C72(0.84)  LDD2169  [14]
 LDCM0276  AC17 HEK-293T C72(0.97)  LDD1515  [13]
 LDCM0277  AC18 HEK-293T C72(1.07)  LDD1516  [13]
 LDCM0278  AC19 HEK-293T C72(1.02); C92(1.15)  LDD1517  [13]
 LDCM0279  AC2 HEK-293T C72(0.90)  LDD1518  [13]
 LDCM0280  AC20 HEK-293T C92(0.92)  LDD1519  [13]
 LDCM0281  AC21 HEK-293T C72(0.96)  LDD1520  [13]
 LDCM0282  AC22 HEK-293T C72(1.06); C92(1.07)  LDD1521  [13]
 LDCM0283  AC23 HEK-293T C72(1.03)  LDD1522  [13]
 LDCM0284  AC24 HEK-293T C72(1.09); C92(0.86)  LDD1523  [13]
 LDCM0285  AC25 HEK-293T C72(0.99)  LDD1524  [13]
 LDCM0286  AC26 HEK-293T C72(0.93)  LDD1525  [13]
 LDCM0287  AC27 HEK-293T C72(1.03); C92(1.24)  LDD1526  [13]
 LDCM0288  AC28 HEK-293T C92(0.81)  LDD1527  [13]
 LDCM0289  AC29 HEK-293T C72(1.10)  LDD1528  [13]
 LDCM0290  AC3 HEK-293T C72(1.05); C92(1.11)  LDD1529  [13]
 LDCM0291  AC30 HEK-293T C72(0.99); C92(1.10)  LDD1530  [13]
 LDCM0292  AC31 HEK-293T C72(1.03)  LDD1531  [13]
 LDCM0293  AC32 HEK-293T C72(1.01); C92(1.02)  LDD1532  [13]
 LDCM0294  AC33 HEK-293T C72(1.27)  LDD1533  [13]
 LDCM0295  AC34 HEK-293T C72(1.10)  LDD1534  [13]
 LDCM0296  AC35 HEK-293T C72(1.03); C92(0.90)  LDD1535  [13]
 LDCM0297  AC36 HEK-293T C92(0.86)  LDD1536  [13]
 LDCM0298  AC37 HEK-293T C72(1.02)  LDD1537  [13]
 LDCM0299  AC38 HEK-293T C72(0.97); C92(1.03)  LDD1538  [13]
 LDCM0300  AC39 HEK-293T C72(0.99)  LDD1539  [13]
 LDCM0301  AC4 HEK-293T C92(1.27)  LDD1540  [13]
 LDCM0302  AC40 HEK-293T C72(1.02); C92(1.02)  LDD1541  [13]
 LDCM0303  AC41 HEK-293T C72(1.19)  LDD1542  [13]
 LDCM0304  AC42 HEK-293T C72(1.16)  LDD1543  [13]
 LDCM0305  AC43 HEK-293T C72(0.91); C92(1.10)  LDD1544  [13]
 LDCM0306  AC44 HEK-293T C92(0.84)  LDD1545  [13]
 LDCM0307  AC45 HEK-293T C72(1.16)  LDD1546  [13]
 LDCM0308  AC46 PaTu 8988t C72(1.01)  LDD1187  [14]
 LDCM0309  AC47 PaTu 8988t C72(1.07)  LDD1188  [14]
 LDCM0310  AC48 PaTu 8988t C72(1.14)  LDD1189  [14]
 LDCM0311  AC49 PaTu 8988t C72(1.54)  LDD1190  [14]
 LDCM0312  AC5 HEK-293T C72(1.13)  LDD1551  [13]
 LDCM0313  AC50 PaTu 8988t C72(1.67)  LDD1192  [14]
 LDCM0314  AC51 PaTu 8988t C72(0.43)  LDD1193  [14]
 LDCM0315  AC52 PaTu 8988t C72(1.37)  LDD1194  [14]
 LDCM0316  AC53 PaTu 8988t C72(1.66)  LDD1195  [14]
 LDCM0317  AC54 PaTu 8988t C72(1.53)  LDD1196  [14]
 LDCM0318  AC55 PaTu 8988t C72(1.36)  LDD1197  [14]
 LDCM0319  AC56 PaTu 8988t C72(1.59)  LDD1198  [14]
 LDCM0320  AC57 PaTu 8988t C72(1.12)  LDD1199  [14]
 LDCM0321  AC58 PaTu 8988t C72(1.18)  LDD1200  [14]
 LDCM0322  AC59 PaTu 8988t C72(1.19)  LDD1201  [14]
 LDCM0323  AC6 HEK-293T C72(0.95); C92(1.10)  LDD1562  [13]
 LDCM0324  AC60 PaTu 8988t C72(1.13)  LDD1203  [14]
 LDCM0325  AC61 PaTu 8988t C72(1.08)  LDD1204  [14]
 LDCM0326  AC62 PaTu 8988t C72(1.12)  LDD1205  [14]
 LDCM0327  AC63 PaTu 8988t C72(0.96)  LDD1206  [14]
 LDCM0328  AC64 PaTu 8988t C72(0.92)  LDD1207  [14]
 LDCM0329  AC65 PaTu 8988t C72(1.01)  LDD1208  [14]
 LDCM0330  AC66 PaTu 8988t C72(1.07)  LDD1209  [14]
 LDCM0331  AC67 PaTu 8988t C72(0.95)  LDD1210  [14]
 LDCM0334  AC7 HEK-293T C72(0.97)  LDD1568  [13]
 LDCM0345  AC8 HEK-293T C72(0.99); C92(1.03)  LDD1569  [13]
 LDCM0349  AC83 PaTu 8988t C72(1.02)  LDD1228  [14]
 LDCM0350  AC84 PaTu 8988t C72(0.98)  LDD1229  [14]
 LDCM0351  AC85 PaTu 8988t C72(1.00)  LDD1230  [14]
 LDCM0352  AC86 PaTu 8988t C72(1.00)  LDD1231  [14]
 LDCM0353  AC87 PaTu 8988t C72(1.01)  LDD1232  [14]
 LDCM0354  AC88 PaTu 8988t C72(0.93)  LDD1233  [14]
 LDCM0355  AC89 PaTu 8988t C72(0.90)  LDD1234  [14]
 LDCM0357  AC90 PaTu 8988t C72(0.99)  LDD1236  [14]
 LDCM0358  AC91 PaTu 8988t C72(0.97)  LDD1237  [14]
 LDCM0359  AC92 PaTu 8988t C72(0.98)  LDD1238  [14]
 LDCM0360  AC93 PaTu 8988t C72(0.92)  LDD1239  [14]
 LDCM0361  AC94 PaTu 8988t C72(0.92)  LDD1240  [14]
 LDCM0362  AC95 PaTu 8988t C72(0.95)  LDD1241  [14]
 LDCM0363  AC96 PaTu 8988t C72(0.85)  LDD1242  [14]
 LDCM0364  AC97 PaTu 8988t C72(0.88)  LDD1243  [14]
 LDCM0365  AC98 PaTu 8988t C72(1.01)  LDD1244  [14]
 LDCM0366  AC99 PaTu 8988t C72(0.97)  LDD1245  [14]
 LDCM0248  AKOS034007472 HEK-293T C72(1.05)  LDD1511  [13]
 LDCM0356  AKOS034007680 HEK-293T C72(1.09)  LDD1570  [13]
 LDCM0275  AKOS034007705 HEK-293T C72(1.09); C92(0.86)  LDD1514  [13]
 LDCM0156  Aniline NCI-H1299 14.96  LDD0403  [2]
 LDCM0632  CL-Sc Hep-G2 C72(0.83)  LDD2227  [8]
 LDCM0367  CL1 HEK-293T C72(1.09)  LDD1571  [13]
 LDCM0368  CL10 HEK-293T C72(0.85); C92(0.88)  LDD1572  [13]
 LDCM0369  CL100 HEK-293T C72(1.00)  LDD1573  [13]
 LDCM0370  CL101 HEK-293T C72(1.03)  LDD1574  [13]
 LDCM0371  CL102 HEK-293T C72(0.95)  LDD1575  [13]
 LDCM0372  CL103 HEK-293T C72(1.05)  LDD1576  [13]
 LDCM0373  CL104 HEK-293T C72(0.92)  LDD1577  [13]
 LDCM0374  CL105 HEK-293T C72(0.99)  LDD1578  [13]
 LDCM0375  CL106 HEK-293T C72(0.94)  LDD1579  [13]
 LDCM0376  CL107 HEK-293T C72(1.07)  LDD1580  [13]
 LDCM0377  CL108 HEK-293T C72(0.98)  LDD1581  [13]
 LDCM0378  CL109 HEK-293T C72(1.03)  LDD1582  [13]
 LDCM0379  CL11 HEK-293T C72(1.05)  LDD1583  [13]
 LDCM0380  CL110 HEK-293T C72(0.83)  LDD1584  [13]
 LDCM0381  CL111 HEK-293T C72(1.09)  LDD1585  [13]
 LDCM0382  CL112 HEK-293T C72(1.06)  LDD1586  [13]
 LDCM0383  CL113 HEK-293T C72(1.06)  LDD1587  [13]
 LDCM0384  CL114 HEK-293T C72(0.86)  LDD1588  [13]
 LDCM0385  CL115 HEK-293T C72(1.10)  LDD1589  [13]
 LDCM0386  CL116 HEK-293T C72(1.09)  LDD1590  [13]
 LDCM0387  CL117 HEK-293T C72(1.06)  LDD1591  [13]
 LDCM0388  CL118 HEK-293T C72(1.07)  LDD1592  [13]
 LDCM0389  CL119 HEK-293T C72(1.11)  LDD1593  [13]
 LDCM0390  CL12 HEK-293T C72(0.93); C92(1.11)  LDD1594  [13]
 LDCM0391  CL120 HEK-293T C72(1.15)  LDD1595  [13]
 LDCM0392  CL121 PaTu 8988t C72(1.14)  LDD1271  [14]
 LDCM0393  CL122 PaTu 8988t C72(1.23)  LDD1272  [14]
 LDCM0394  CL123 PaTu 8988t C72(1.57)  LDD1273  [14]
 LDCM0395  CL124 PaTu 8988t C72(1.48)  LDD1274  [14]
 LDCM0396  CL125 PaTu 8988t C72(1.09)  LDD1275  [14]
 LDCM0397  CL126 PaTu 8988t C72(0.99)  LDD1276  [14]
 LDCM0398  CL127 PaTu 8988t C72(1.02)  LDD1277  [14]
 LDCM0399  CL128 PaTu 8988t C72(1.10)  LDD1278  [14]
 LDCM0400  CL13 HEK-293T C72(1.16)  LDD1604  [13]
 LDCM0401  CL14 HEK-293T C72(1.09)  LDD1605  [13]
 LDCM0402  CL15 HEK-293T C72(1.29)  LDD1606  [13]
 LDCM0403  CL16 PaTu 8988t C72(0.89)  LDD1282  [14]
 LDCM0404  CL17 PaTu 8988t C72(0.86)  LDD1283  [14]
 LDCM0405  CL18 PaTu 8988t C72(0.88)  LDD1284  [14]
 LDCM0406  CL19 PaTu 8988t C72(0.82)  LDD1285  [14]
 LDCM0407  CL2 HEK-293T C72(1.12)  LDD1611  [13]
 LDCM0408  CL20 PaTu 8988t C72(0.81)  LDD1287  [14]
 LDCM0409  CL21 PaTu 8988t C72(0.98)  LDD1288  [14]
 LDCM0410  CL22 PaTu 8988t C72(0.97)  LDD1289  [14]
 LDCM0411  CL23 PaTu 8988t C72(0.93)  LDD1290  [14]
 LDCM0412  CL24 PaTu 8988t C72(1.00)  LDD1291  [14]
 LDCM0413  CL25 PaTu 8988t C72(1.01)  LDD1292  [14]
 LDCM0414  CL26 PaTu 8988t C72(0.88)  LDD1293  [14]
 LDCM0415  CL27 PaTu 8988t C72(1.01)  LDD1294  [14]
 LDCM0416  CL28 PaTu 8988t C72(0.95)  LDD1295  [14]
 LDCM0417  CL29 PaTu 8988t C72(0.97)  LDD1296  [14]
 LDCM0418  CL3 HEK-293T C72(1.06)  LDD1622  [13]
 LDCM0419  CL30 PaTu 8988t C72(0.98)  LDD1298  [14]
 LDCM0420  CL31 HEK-293T C72(1.01); C92(0.92)  LDD1624  [13]
 LDCM0421  CL32 HEK-293T C92(0.85)  LDD1625  [13]
 LDCM0422  CL33 HEK-293T C72(1.14)  LDD1626  [13]
 LDCM0423  CL34 HEK-293T C72(0.91); C92(0.28)  LDD1627  [13]
 LDCM0424  CL35 HEK-293T C72(0.98)  LDD1628  [13]
 LDCM0425  CL36 HEK-293T C72(1.18); C92(1.00)  LDD1629  [13]
 LDCM0426  CL37 HEK-293T C72(0.99)  LDD1630  [13]
 LDCM0428  CL39 HEK-293T C72(1.09)  LDD1632  [13]
 LDCM0429  CL4 HEK-293T C72(1.29)  LDD1633  [13]
 LDCM0430  CL40 HEK-293T C72(0.98)  LDD1634  [13]
 LDCM0431  CL41 HEK-293T C72(1.14)  LDD1635  [13]
 LDCM0432  CL42 HEK-293T C72(1.11)  LDD1636  [13]
 LDCM0433  CL43 HEK-293T C72(0.99); C92(0.85)  LDD1637  [13]
 LDCM0434  CL44 HEK-293T C92(1.38)  LDD1638  [13]
 LDCM0435  CL45 HEK-293T C72(1.14)  LDD1639  [13]
 LDCM0436  CL46 PaTu 8988t C72(1.02)  LDD1315  [14]
 LDCM0437  CL47 PaTu 8988t C72(0.96)  LDD1316  [14]
 LDCM0438  CL48 PaTu 8988t C72(1.09)  LDD1317  [14]
 LDCM0439  CL49 PaTu 8988t C72(1.12)  LDD1318  [14]
 LDCM0440  CL5 HEK-293T C72(0.98)  LDD1644  [13]
 LDCM0441  CL50 PaTu 8988t C72(1.02)  LDD1320  [14]
 LDCM0442  CL51 PaTu 8988t C72(1.07)  LDD1321  [14]
 LDCM0443  CL52 PaTu 8988t C72(1.17)  LDD1322  [14]
 LDCM0444  CL53 PaTu 8988t C72(1.25)  LDD1323  [14]
 LDCM0445  CL54 PaTu 8988t C72(1.10)  LDD1324  [14]
 LDCM0446  CL55 PaTu 8988t C72(1.28)  LDD1325  [14]
 LDCM0447  CL56 PaTu 8988t C72(1.03)  LDD1326  [14]
 LDCM0448  CL57 PaTu 8988t C72(1.18)  LDD1327  [14]
 LDCM0449  CL58 PaTu 8988t C72(1.28)  LDD1328  [14]
 LDCM0450  CL59 PaTu 8988t C72(1.03)  LDD1329  [14]
 LDCM0451  CL6 HEK-293T C72(1.42)  LDD1654  [13]
 LDCM0452  CL60 PaTu 8988t C72(1.12)  LDD1331  [14]
 LDCM0453  CL61 HEK-293T C72(0.95)  LDD1656  [13]
 LDCM0454  CL62 HEK-293T C72(1.00)  LDD1657  [13]
 LDCM0455  CL63 HEK-293T C72(1.08)  LDD1658  [13]
 LDCM0456  CL64 HEK-293T C72(0.94)  LDD1659  [13]
 LDCM0457  CL65 HEK-293T C72(1.07)  LDD1660  [13]
 LDCM0458  CL66 HEK-293T C72(0.87)  LDD1661  [13]
 LDCM0459  CL67 HEK-293T C72(0.96); C92(1.36)  LDD1662  [13]
 LDCM0460  CL68 HEK-293T C92(1.14)  LDD1663  [13]
 LDCM0461  CL69 HEK-293T C72(1.07)  LDD1664  [13]
 LDCM0462  CL7 HEK-293T C72(1.04); C92(1.51)  LDD1665  [13]
 LDCM0463  CL70 HEK-293T C72(1.09); C92(0.96)  LDD1666  [13]
 LDCM0464  CL71 HEK-293T C72(0.99)  LDD1667  [13]
 LDCM0465  CL72 HEK-293T C72(0.95); C92(1.02)  LDD1668  [13]
 LDCM0466  CL73 HEK-293T C72(1.06)  LDD1669  [13]
 LDCM0467  CL74 HEK-293T C72(1.04)  LDD1670  [13]
 LDCM0469  CL76 PaTu 8988t C72(0.98)  LDD1348  [14]
 LDCM0470  CL77 PaTu 8988t C72(1.05)  LDD1349  [14]
 LDCM0471  CL78 PaTu 8988t C72(1.22)  LDD1350  [14]
 LDCM0472  CL79 PaTu 8988t C72(1.28)  LDD1351  [14]
 LDCM0473  CL8 HEK-293T C92(1.45)  LDD1676  [13]
 LDCM0474  CL80 PaTu 8988t C72(1.15)  LDD1353  [14]
 LDCM0475  CL81 PaTu 8988t C72(1.27)  LDD1354  [14]
 LDCM0476  CL82 PaTu 8988t C72(1.31)  LDD1355  [14]
 LDCM0477  CL83 PaTu 8988t C72(1.41)  LDD1356  [14]
 LDCM0478  CL84 PaTu 8988t C72(1.05)  LDD1357  [14]
 LDCM0479  CL85 PaTu 8988t C72(1.16)  LDD1358  [14]
 LDCM0480  CL86 PaTu 8988t C72(1.37)  LDD1359  [14]
 LDCM0481  CL87 PaTu 8988t C72(1.31)  LDD1360  [14]
 LDCM0482  CL88 PaTu 8988t C72(1.44)  LDD1361  [14]
 LDCM0483  CL89 PaTu 8988t C72(1.13)  LDD1362  [14]
 LDCM0484  CL9 HEK-293T C72(1.16)  LDD1687  [13]
 LDCM0485  CL90 PaTu 8988t C72(1.63)  LDD1364  [14]
 LDCM0486  CL91 HEK-293T C72(1.04); C92(0.74)  LDD1689  [13]
 LDCM0487  CL92 HEK-293T C92(1.15)  LDD1690  [13]
 LDCM0488  CL93 HEK-293T C72(1.10)  LDD1691  [13]
 LDCM0489  CL94 HEK-293T C72(1.01); C92(1.00)  LDD1692  [13]
 LDCM0490  CL95 HEK-293T C72(1.02)  LDD1693  [13]
 LDCM0491  CL96 HEK-293T C72(0.94); C92(0.92)  LDD1694  [13]
 LDCM0492  CL97 HEK-293T C72(1.11)  LDD1695  [13]
 LDCM0493  CL98 HEK-293T C72(0.99)  LDD1696  [13]
 LDCM0494  CL99 HEK-293T C72(0.94)  LDD1697  [13]
 LDCM0495  E2913 HEK-293T C72(1.12)  LDD1698  [13]
 LDCM0468  Fragment33 HEK-293T C72(0.94)  LDD1671  [13]
 LDCM0427  Fragment51 HEK-293T C72(1.00)  LDD1631  [13]
 LDCM0022  KB02 HEK-293T C72(1.01)  LDD1492  [13]
 LDCM0023  KB03 HEK-293T C72(1.00)  LDD1497  [13]
 LDCM0024  KB05 NALM-6 C72(2.57)  LDD3339  [3]
 LDCM0109  NEM HeLa N.A.  LDD0223  [5]
 LDCM0507  Nucleophilic fragment 16b MDA-MB-231 C72(0.96)  LDD2100  [4]
 LDCM0628  OTUB2-COV-1 HEK-293T C72(0.54)  LDD2207  [15]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Other
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Trefoil factor 2 (TFF2) . Q03403

References

1 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
2 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
3 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
4 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
5 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
6 Targeted Proteomic Approaches for Proteome-Wide Characterizations of the AMP-Binding Capacities of Kinases. J Proteome Res. 2022 Aug 5;21(8):2063-2070. doi: 10.1021/acs.jproteome.2c00225. Epub 2022 Jul 12.
7 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
8 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
9 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
10 Site-Specific Activity-Based Protein Profiling Using Phosphonate Handles. Mol Cell Proteomics. 2023 Jan;22(1):100455. doi: 10.1016/j.mcpro.2022.100455. Epub 2022 Nov 24.
Mass spectrometry data entry: PXD036569
11 DFT-Guided Discovery of Ethynyl-Triazolyl-Phosphinates as Modular Electrophiles for Chemoselective Cysteine Bioconjugation and Profiling. Angew Chem Int Ed Engl. 2022 Oct 10;61(41):e202205348. doi: 10.1002/anie.202205348. Epub 2022 Aug 22.
Mass spectrometry data entry: PXD033004
12 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
13 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
14 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
15 Rapid Covalent-Probe Discovery by Electrophile-Fragment Screening. J Am Chem Soc. 2019 Jun 5;141(22):8951-8968. doi: 10.1021/jacs.9b02822. Epub 2019 May 22.