Details of the Target

General Information of Target

Target ID LDTP06405
Target Name Mediator of RNA polymerase II transcription subunit 22 (MED22)
Gene Name MED22
Gene ID 6837
Synonyms
SURF5; Mediator of RNA polymerase II transcription subunit 22; Mediator complex subunit 22; Surfeit locus protein 5; Surf-5
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MAQQRALPQSKETLLQSYNKRLKDDIKSIMDNFTEIIKTAKIEDETQVSRATQGEQDNYE
MHVRAANIVRAGESLMKLVSDLKQFLILNDFPSVNEAIDQRNQQLRTLQEECDRKLITLR
DEISIDLYELEEEYYSSSSSLCEANDLPLCEAYGRLDLDTDSADGLSAPLLASPEPSAGP
LQVAAPAHSHAGGPGPTEHA
Target Bioclass
Other
Family
Mediator complex subunit 22 family
Subcellular location
Nucleus
Function
Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.
Uniprot ID
Q15528
Ensemble ID
ENST00000343730.10
HGNC ID
HGNC:11477

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
PATU8988T SNV: p.L147R DBIA    Probe Info 

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 6 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
BTD
 Probe Info  		C112(0.40)  LDD2100  [1]
Acrolein
 Probe Info  		N.A.  LDD0227  [2]
DBIA
 Probe Info  		C112(1.22)  LDD0531  [3]
IA-alkyne
 Probe Info  		N.A.  LDD0036  [4]
TFBX
 Probe Info  		N.A.  LDD0027  [5]
Methacrolein
 Probe Info  		N.A.  LDD0218  [2]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0548  1-(4-(Benzo[d][1,3]dioxol-5-ylmethyl)piperazin-1-yl)-2-nitroethan-1-one MDA-MB-231 C112(0.58)  LDD2142  [1]
 LDCM0519  1-(6-methoxy-3,4-dihydroquinolin-1(2H)-yl)-2-nitroethan-1-one MDA-MB-231 C112(0.68)  LDD2112  [1]
 LDCM0214  AC1 HCT 116 C112(1.22)  LDD0531  [3]
 LDCM0215  AC10 PaTu 8988t C112(1.02)  LDD1094  [3]
 LDCM0216  AC100 HCT 116 C112(0.49)  LDD0533  [3]
 LDCM0217  AC101 HCT 116 C112(0.42)  LDD0534  [3]
 LDCM0218  AC102 HCT 116 C112(0.60)  LDD0535  [3]
 LDCM0219  AC103 HCT 116 C112(0.60)  LDD0536  [3]
 LDCM0220  AC104 HCT 116 C112(0.81)  LDD0537  [3]
 LDCM0221  AC105 HCT 116 C112(0.69)  LDD0538  [3]
 LDCM0222  AC106 HCT 116 C112(0.55)  LDD0539  [3]
 LDCM0223  AC107 HCT 116 C112(0.81)  LDD0540  [3]
 LDCM0224  AC108 HCT 116 C112(0.57)  LDD0541  [3]
 LDCM0225  AC109 HCT 116 C112(0.44)  LDD0542  [3]
 LDCM0226  AC11 PaTu 8988t C112(0.95)  LDD1105  [3]
 LDCM0227  AC110 HCT 116 C112(0.55)  LDD0544  [3]
 LDCM0228  AC111 HCT 116 C112(0.55)  LDD0545  [3]
 LDCM0229  AC112 HCT 116 C112(0.60)  LDD0546  [3]
 LDCM0230  AC113 PaTu 8988t C112(0.95)  LDD1109  [3]
 LDCM0231  AC114 PaTu 8988t C112(0.73)  LDD1110  [3]
 LDCM0232  AC115 PaTu 8988t C112(1.24)  LDD1111  [3]
 LDCM0233  AC116 PaTu 8988t C112(1.23)  LDD1112  [3]
 LDCM0234  AC117 PaTu 8988t C112(0.99)  LDD1113  [3]
 LDCM0235  AC118 PaTu 8988t C112(1.10)  LDD1114  [3]
 LDCM0236  AC119 PaTu 8988t C112(1.15)  LDD1115  [3]
 LDCM0237  AC12 PaTu 8988t C112(0.97)  LDD1116  [3]
 LDCM0238  AC120 PaTu 8988t C112(1.27)  LDD1117  [3]
 LDCM0239  AC121 PaTu 8988t C112(0.91)  LDD1118  [3]
 LDCM0240  AC122 PaTu 8988t C112(0.83)  LDD1119  [3]
 LDCM0241  AC123 PaTu 8988t C112(1.29)  LDD1120  [3]
 LDCM0242  AC124 PaTu 8988t C112(1.24)  LDD1121  [3]
 LDCM0243  AC125 PaTu 8988t C112(0.81)  LDD1122  [3]
 LDCM0244  AC126 PaTu 8988t C112(0.95)  LDD1123  [3]
 LDCM0245  AC127 PaTu 8988t C112(1.32)  LDD1124  [3]
 LDCM0246  AC128 PaTu 8988t C112(1.32)  LDD1125  [3]
 LDCM0247  AC129 PaTu 8988t C112(1.51)  LDD1126  [3]
 LDCM0249  AC130 PaTu 8988t C112(1.01)  LDD1128  [3]
 LDCM0250  AC131 PaTu 8988t C112(1.11)  LDD1129  [3]
 LDCM0251  AC132 PaTu 8988t C112(1.33)  LDD1130  [3]
 LDCM0252  AC133 PaTu 8988t C112(2.16)  LDD1131  [3]
 LDCM0253  AC134 PaTu 8988t C112(1.03)  LDD1132  [3]
 LDCM0254  AC135 PaTu 8988t C112(1.25)  LDD1133  [3]
 LDCM0255  AC136 PaTu 8988t C112(1.36)  LDD1134  [3]
 LDCM0256  AC137 PaTu 8988t C112(1.82)  LDD1135  [3]
 LDCM0257  AC138 PaTu 8988t C112(0.74)  LDD1136  [3]
 LDCM0258  AC139 PaTu 8988t C112(1.46)  LDD1137  [3]
 LDCM0259  AC14 PaTu 8988t C112(0.97)  LDD1138  [3]
 LDCM0260  AC140 PaTu 8988t C112(0.83)  LDD1139  [3]
 LDCM0261  AC141 PaTu 8988t C112(1.27)  LDD1140  [3]
 LDCM0262  AC142 PaTu 8988t C112(1.13)  LDD1141  [3]
 LDCM0263  AC143 HCT 116 C112(0.69)  LDD0580  [3]
 LDCM0264  AC144 HCT 116 C112(1.00)  LDD0581  [3]
 LDCM0265  AC145 HCT 116 C112(0.96)  LDD0582  [3]
 LDCM0266  AC146 HCT 116 C112(0.62)  LDD0583  [3]
 LDCM0267  AC147 HCT 116 C112(1.25)  LDD0584  [3]
 LDCM0268  AC148 HCT 116 C112(0.61)  LDD0585  [3]
 LDCM0269  AC149 HCT 116 C112(0.65)  LDD0586  [3]
 LDCM0270  AC15 PaTu 8988t C112(1.18)  LDD1149  [3]
 LDCM0271  AC150 HCT 116 C112(0.96)  LDD0588  [3]
 LDCM0272  AC151 HCT 116 C112(0.81)  LDD0589  [3]
 LDCM0273  AC152 HCT 116 C112(0.80)  LDD0590  [3]
 LDCM0274  AC153 HCT 116 C112(0.58)  LDD0591  [3]
 LDCM0621  AC154 HCT 116 C112(0.86)  LDD2158  [3]
 LDCM0622  AC155 HCT 116 C112(0.61)  LDD2159  [3]
 LDCM0623  AC156 HCT 116 C112(0.78)  LDD2160  [3]
 LDCM0624  AC157 HCT 116 C112(0.65)  LDD2161  [3]
 LDCM0276  AC17 PaTu 8988t C112(1.61)  LDD1155  [3]
 LDCM0277  AC18 PaTu 8988t C112(1.69)  LDD1156  [3]
 LDCM0278  AC19 PaTu 8988t C112(1.33)  LDD1157  [3]
 LDCM0279  AC2 HCT 116 C112(1.41)  LDD0596  [3]
 LDCM0280  AC20 PaTu 8988t C112(2.14)  LDD1159  [3]
 LDCM0281  AC21 PaTu 8988t C112(1.61)  LDD1160  [3]
 LDCM0282  AC22 PaTu 8988t C112(1.59)  LDD1161  [3]
 LDCM0283  AC23 PaTu 8988t C112(1.86)  LDD1162  [3]
 LDCM0284  AC24 PaTu 8988t C112(2.38)  LDD1163  [3]
 LDCM0288  AC28 HEK-293T C112(1.04)  LDD1527  [6]
 LDCM0289  AC29 HEK-293T C112(1.24)  LDD1528  [6]
 LDCM0290  AC3 HCT 116 C112(2.20)  LDD0607  [3]
 LDCM0291  AC30 HEK-293T C112(1.17)  LDD1530  [6]
 LDCM0293  AC32 HEK-293T C112(1.03)  LDD1532  [6]
 LDCM0297  AC36 HEK-293T C112(1.33)  LDD1536  [6]
 LDCM0298  AC37 HEK-293T C112(1.08)  LDD1537  [6]
 LDCM0299  AC38 HEK-293T C112(1.17)  LDD1538  [6]
 LDCM0301  AC4 HCT 116 C112(1.47)  LDD0618  [3]
 LDCM0302  AC40 HEK-293T C112(1.06)  LDD1541  [6]
 LDCM0306  AC44 HEK-293T C112(1.31)  LDD1545  [6]
 LDCM0307  AC45 HEK-293T C112(1.07)  LDD1546  [6]
 LDCM0308  AC46 HEK-293T C112(1.23)  LDD1547  [6]
 LDCM0309  AC47 HCT 116 C112(0.73)  LDD0626  [3]
 LDCM0310  AC48 HCT 116 C112(0.72)  LDD0627  [3]
 LDCM0311  AC49 HCT 116 C112(0.94)  LDD0628  [3]
 LDCM0312  AC5 HCT 116 C112(1.80)  LDD0629  [3]
 LDCM0313  AC50 HCT 116 C112(0.80)  LDD0630  [3]
 LDCM0314  AC51 HCT 116 C112(0.74)  LDD0631  [3]
 LDCM0315  AC52 HCT 116 C112(0.72)  LDD0632  [3]
 LDCM0316  AC53 HCT 116 C112(0.49)  LDD0633  [3]
 LDCM0317  AC54 HCT 116 C112(1.14)  LDD0634  [3]
 LDCM0318  AC55 HCT 116 C112(0.82)  LDD0635  [3]
 LDCM0319  AC56 HCT 116 C112(0.57)  LDD0636  [3]
 LDCM0320  AC57 HCT 116 C112(1.14)  LDD0637  [3]
 LDCM0321  AC58 HCT 116 C112(0.67)  LDD0638  [3]
 LDCM0322  AC59 HCT 116 C112(1.11)  LDD0639  [3]
 LDCM0323  AC6 PaTu 8988t C112(0.93)  LDD1202  [3]
 LDCM0324  AC60 HCT 116 C112(1.07)  LDD0641  [3]
 LDCM0325  AC61 HCT 116 C112(0.99)  LDD0642  [3]
 LDCM0326  AC62 HCT 116 C112(0.86)  LDD0643  [3]
 LDCM0327  AC63 HCT 116 C112(0.98)  LDD0644  [3]
 LDCM0328  AC64 HCT 116 C112(0.86)  LDD0645  [3]
 LDCM0329  AC65 HCT 116 C112(1.04)  LDD0646  [3]
 LDCM0330  AC66 HCT 116 C112(0.74)  LDD0647  [3]
 LDCM0331  AC67 HCT 116 C112(0.83)  LDD0648  [3]
 LDCM0334  AC7 PaTu 8988t C112(1.02)  LDD1213  [3]
 LDCM0345  AC8 PaTu 8988t C112(1.20)  LDD1224  [3]
 LDCM0349  AC83 HCT 116 C112(0.76)  LDD0666  [3]
 LDCM0350  AC84 HCT 116 C112(0.86)  LDD0667  [3]
 LDCM0351  AC85 HCT 116 C112(0.90)  LDD0668  [3]
 LDCM0352  AC86 HCT 116 C112(1.30)  LDD0669  [3]
 LDCM0353  AC87 HCT 116 C112(1.33)  LDD0670  [3]
 LDCM0354  AC88 HCT 116 C112(1.11)  LDD0671  [3]
 LDCM0355  AC89 HCT 116 C112(0.83)  LDD0672  [3]
 LDCM0357  AC90 HCT 116 C112(1.08)  LDD0674  [3]
 LDCM0358  AC91 HCT 116 C112(0.96)  LDD0675  [3]
 LDCM0359  AC92 HCT 116 C112(0.88)  LDD0676  [3]
 LDCM0360  AC93 HCT 116 C112(0.88)  LDD0677  [3]
 LDCM0361  AC94 HCT 116 C112(0.97)  LDD0678  [3]
 LDCM0362  AC95 HCT 116 C112(0.99)  LDD0679  [3]
 LDCM0363  AC96 HCT 116 C112(0.91)  LDD0680  [3]
 LDCM0364  AC97 HCT 116 C112(0.93)  LDD0681  [3]
 LDCM0365  AC98 HCT 116 C112(0.66)  LDD0682  [3]
 LDCM0366  AC99 HCT 116 C112(0.95)  LDD0683  [3]
 LDCM0248  AKOS034007472 PaTu 8988t C112(1.09)  LDD1127  [3]
 LDCM0356  AKOS034007680 PaTu 8988t C112(1.72)  LDD1235  [3]
 LDCM0275  AKOS034007705 PaTu 8988t C112(0.92)  LDD1154  [3]
 LDCM0367  CL1 PaTu 8988t C112(1.69)  LDD1246  [3]
 LDCM0368  CL10 PaTu 8988t C112(1.09)  LDD1247  [3]
 LDCM0369  CL100 HCT 116 C112(2.06)  LDD0686  [3]
 LDCM0370  CL101 PaTu 8988t C112(1.54)  LDD1249  [3]
 LDCM0371  CL102 PaTu 8988t C112(1.02)  LDD1250  [3]
 LDCM0372  CL103 PaTu 8988t C112(1.28)  LDD1251  [3]
 LDCM0373  CL104 PaTu 8988t C112(0.97)  LDD1252  [3]
 LDCM0374  CL105 PaTu 8988t C112(1.76)  LDD1253  [3]
 LDCM0375  CL106 PaTu 8988t C112(1.22)  LDD1254  [3]
 LDCM0376  CL107 PaTu 8988t C112(1.56)  LDD1255  [3]
 LDCM0377  CL108 PaTu 8988t C112(1.25)  LDD1256  [3]
 LDCM0378  CL109 PaTu 8988t C112(1.44)  LDD1257  [3]
 LDCM0379  CL11 PaTu 8988t C112(1.13)  LDD1258  [3]
 LDCM0380  CL110 PaTu 8988t C112(1.49)  LDD1259  [3]
 LDCM0381  CL111 PaTu 8988t C112(1.75)  LDD1260  [3]
 LDCM0390  CL12 PaTu 8988t C112(0.88)  LDD1269  [3]
 LDCM0392  CL121 HCT 116 C112(0.90)  LDD0709  [3]
 LDCM0393  CL122 HCT 116 C112(1.20)  LDD0710  [3]
 LDCM0394  CL123 HCT 116 C112(0.51)  LDD0711  [3]
 LDCM0395  CL124 HCT 116 C112(0.58)  LDD0712  [3]
 LDCM0396  CL125 HCT 116 C112(1.32)  LDD0713  [3]
 LDCM0397  CL126 HCT 116 C112(0.74)  LDD0714  [3]
 LDCM0398  CL127 HCT 116 C112(0.92)  LDD0715  [3]
 LDCM0399  CL128 HCT 116 C112(0.79)  LDD0716  [3]
 LDCM0400  CL13 PaTu 8988t C112(1.59)  LDD1279  [3]
 LDCM0401  CL14 PaTu 8988t C112(1.84)  LDD1280  [3]
 LDCM0402  CL15 PaTu 8988t C112(0.82)  LDD1281  [3]
 LDCM0403  CL16 HCT 116 C112(0.65)  LDD0720  [3]
 LDCM0404  CL17 HCT 116 C112(1.10)  LDD0721  [3]
 LDCM0405  CL18 HCT 116 C112(1.20)  LDD0722  [3]
 LDCM0406  CL19 HCT 116 C112(1.22)  LDD0723  [3]
 LDCM0407  CL2 PaTu 8988t C112(1.49)  LDD1286  [3]
 LDCM0408  CL20 HCT 116 C112(1.20)  LDD0725  [3]
 LDCM0409  CL21 HCT 116 C112(1.12)  LDD0726  [3]
 LDCM0410  CL22 HCT 116 C112(1.09)  LDD0727  [3]
 LDCM0411  CL23 HCT 116 C112(0.98)  LDD0728  [3]
 LDCM0412  CL24 HCT 116 C112(1.22)  LDD0729  [3]
 LDCM0413  CL25 HCT 116 C112(1.07)  LDD0730  [3]
 LDCM0414  CL26 HCT 116 C112(1.07)  LDD0731  [3]
 LDCM0415  CL27 HCT 116 C112(1.52)  LDD0732  [3]
 LDCM0416  CL28 HCT 116 C112(1.45)  LDD0733  [3]
 LDCM0417  CL29 HCT 116 C112(1.40)  LDD0734  [3]
 LDCM0418  CL3 PaTu 8988t C112(1.05)  LDD1297  [3]
 LDCM0419  CL30 HCT 116 C112(1.18)  LDD0736  [3]
 LDCM0420  CL31 HCT 116 C112(1.72)  LDD0737  [3]
 LDCM0421  CL32 PaTu 8988t C112(1.21)  LDD1300  [3]
 LDCM0422  CL33 PaTu 8988t C112(0.92)  LDD1301  [3]
 LDCM0423  CL34 PaTu 8988t C112(1.18)  LDD1302  [3]
 LDCM0424  CL35 PaTu 8988t C112(1.01)  LDD1303  [3]
 LDCM0425  CL36 PaTu 8988t C112(0.30)  LDD1304  [3]
 LDCM0426  CL37 PaTu 8988t C112(1.18)  LDD1305  [3]
 LDCM0428  CL39 PaTu 8988t C112(0.95)  LDD1307  [3]
 LDCM0429  CL4 PaTu 8988t C112(1.14)  LDD1308  [3]
 LDCM0430  CL40 PaTu 8988t C112(1.14)  LDD1309  [3]
 LDCM0431  CL41 PaTu 8988t C112(0.97)  LDD1310  [3]
 LDCM0432  CL42 PaTu 8988t C112(1.23)  LDD1311  [3]
 LDCM0433  CL43 PaTu 8988t C112(1.15)  LDD1312  [3]
 LDCM0434  CL44 PaTu 8988t C112(1.02)  LDD1313  [3]
 LDCM0435  CL45 PaTu 8988t C112(1.15)  LDD1314  [3]
 LDCM0436  CL46 PaTu 8988t C112(0.89)  LDD1315  [3]
 LDCM0437  CL47 PaTu 8988t C112(1.13)  LDD1316  [3]
 LDCM0438  CL48 PaTu 8988t C112(1.25)  LDD1317  [3]
 LDCM0439  CL49 PaTu 8988t C112(0.86)  LDD1318  [3]
 LDCM0440  CL5 PaTu 8988t C112(1.89)  LDD1319  [3]
 LDCM0441  CL50 PaTu 8988t C112(1.11)  LDD1320  [3]
 LDCM0442  CL51 PaTu 8988t C112(1.20)  LDD1321  [3]
 LDCM0443  CL52 PaTu 8988t C112(0.95)  LDD1322  [3]
 LDCM0444  CL53 PaTu 8988t C112(0.92)  LDD1323  [3]
 LDCM0445  CL54 PaTu 8988t C112(0.94)  LDD1324  [3]
 LDCM0446  CL55 PaTu 8988t C112(1.11)  LDD1325  [3]
 LDCM0447  CL56 PaTu 8988t C112(0.12)  LDD1326  [3]
 LDCM0448  CL57 PaTu 8988t C112(1.39)  LDD1327  [3]
 LDCM0449  CL58 PaTu 8988t C112(0.77)  LDD1328  [3]
 LDCM0450  CL59 PaTu 8988t C112(1.62)  LDD1329  [3]
 LDCM0451  CL6 PaTu 8988t C112(0.83)  LDD1330  [3]
 LDCM0452  CL60 PaTu 8988t C112(1.36)  LDD1331  [3]
 LDCM0453  CL61 PaTu 8988t C112(1.32)  LDD1332  [3]
 LDCM0454  CL62 PaTu 8988t C112(0.95)  LDD1333  [3]
 LDCM0455  CL63 PaTu 8988t C112(1.21)  LDD1334  [3]
 LDCM0456  CL64 PaTu 8988t C112(1.09)  LDD1335  [3]
 LDCM0457  CL65 PaTu 8988t C112(0.89)  LDD1336  [3]
 LDCM0458  CL66 PaTu 8988t C112(1.14)  LDD1337  [3]
 LDCM0459  CL67 PaTu 8988t C112(1.77)  LDD1338  [3]
 LDCM0460  CL68 PaTu 8988t C112(1.36)  LDD1339  [3]
 LDCM0461  CL69 PaTu 8988t C112(1.21)  LDD1340  [3]
 LDCM0462  CL7 PaTu 8988t C112(0.82)  LDD1341  [3]
 LDCM0463  CL70 PaTu 8988t C112(0.94)  LDD1342  [3]
 LDCM0464  CL71 PaTu 8988t C112(1.15)  LDD1343  [3]
 LDCM0465  CL72 PaTu 8988t C112(1.09)  LDD1344  [3]
 LDCM0466  CL73 PaTu 8988t C112(0.96)  LDD1345  [3]
 LDCM0467  CL74 PaTu 8988t C112(1.10)  LDD1346  [3]
 LDCM0473  CL8 PaTu 8988t C112(1.30)  LDD1352  [3]
 LDCM0474  CL80 HEK-293T C112(1.08)  LDD1677  [6]
 LDCM0475  CL81 HEK-293T C112(1.12)  LDD1678  [6]
 LDCM0476  CL82 HEK-293T C112(1.10)  LDD1679  [6]
 LDCM0478  CL84 HEK-293T C112(1.08)  LDD1681  [6]
 LDCM0484  CL9 PaTu 8988t C112(1.36)  LDD1363  [3]
 LDCM0486  CL91 HCT 116 C112(1.45)  LDD0803  [3]
 LDCM0487  CL92 HCT 116 C112(0.99)  LDD0804  [3]
 LDCM0488  CL93 HCT 116 C112(0.76)  LDD0805  [3]
 LDCM0489  CL94 HCT 116 C112(1.23)  LDD0806  [3]
 LDCM0490  CL95 HCT 116 C112(1.54)  LDD0807  [3]
 LDCM0491  CL96 HCT 116 C112(1.14)  LDD0808  [3]
 LDCM0492  CL97 HCT 116 C112(1.56)  LDD0809  [3]
 LDCM0493  CL98 HCT 116 C112(2.37)  LDD0810  [3]
 LDCM0494  CL99 HCT 116 C112(1.45)  LDD0811  [3]
 LDCM0468  Fragment33 PaTu 8988t C112(0.94)  LDD1347  [3]
 LDCM0427  Fragment51 PaTu 8988t C112(1.18)  LDD1306  [3]
 LDCM0022  KB02 Caov-3 C112(1.44)  LDD2295  [7]
 LDCM0023  KB03 Caov-3 C112(1.55)  LDD2712  [7]
 LDCM0024  KB05 OAW-42 C112(2.60)  LDD3369  [7]
 LDCM0109  NEM HeLa N.A.  LDD0227  [2]
 LDCM0507  Nucleophilic fragment 16b MDA-MB-231 C112(0.40)  LDD2100  [1]
 LDCM0511  Nucleophilic fragment 18b MDA-MB-231 C112(0.54)  LDD2104  [1]
 LDCM0513  Nucleophilic fragment 19b MDA-MB-231 C112(0.32)  LDD2106  [1]
 LDCM0551  Nucleophilic fragment 5b MDA-MB-231 C112(0.22)  LDD2145  [1]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Protein N-terminal glutamine amidohydrolase (NTAQ1) NTAQ1 family Q96HA8
Ribose-phosphate pyrophosphokinase 1 (PRPS1) Ribose-phosphate pyrophosphokinase family P60891
Transporter and channel
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Huntingtin (HTT) Huntingtin family P42858
Wolframin (WFS1) . O76024
Other
Click To Hide/Show 8 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Mediator of RNA polymerase II transcription subunit 11 (MED11) Mediator complex subunit 11 family Q9P086
Mediator of RNA polymerase II transcription subunit 17 (MED17) Mediator complex subunit 17 family Q9NVC6
Mediator of RNA polymerase II transcription subunit 18 (MED18) Mediator complex subunit 18 family Q9BUE0
Mediator of RNA polymerase II transcription subunit 27 (MED27) Mediator complex subunit 27 family Q6P2C8
Mediator of RNA polymerase II transcription subunit 28 (MED28) Mediator complex subunit 28 family Q9H204
Mediator of RNA polymerase II transcription subunit 29 (MED29) Mediator complex subunit 29 family Q9NX70
Hepatocyte growth factor-regulated tyrosine kinase substrate (HGS) . O14964
Thioredoxin domain-containing protein 9 (TXNDC9) . O14530

References

1 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
2 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
3 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
4 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
5 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
6 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
7 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840