Details of the Target

General Information of Target

Target ID LDTP06397
Target Name SCL-interrupting locus protein (STIL)
Gene Name STIL
Gene ID 6491
Synonyms
SIL; SCL-interrupting locus protein; TAL-1-interrupting locus protein
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MEPIYPFARPQMNTRFPSSRMVPFHFPPSKCALWNPTPTGDFIYLHLSYYRNPKLVVTEK
TIRLAYRHAKQNKKNSSCFLLGSLTADEDEEGVTLTVDRFDPGREVPECLEITPTASLPG
DFLIPCKVHTQELCSREMIVHSVDDFSSALKALQCHICSKDSLDCGKLLSLRVHITSRES
LDSVEFDLHWAAVTLANNFKCTPVKPIPIIPTALARNLSSNLNISQVQGTYKYGYLTMDE
TRKLLLLLESDPKVYSLPLVGIWLSGITHIYSPQVWACCLRYIFNSSVQERVFSESGNFI
IVLYSMTHKEPEFYECFPCDGKIPDFRFQLLTSKETLHLFKNVEPPDKNPIRCELSAESQ
NAETEFFSKASKNFSIKRSSQKLSSGKMPIHDHDSGVEDEDFSPRPIPSPHPVSQKISKI
QPSVPELSLVLDGNFIESNPLPTPLEMVNNENPPLINHLEHLKPLQPQLYDEKHSPEVEA
GEPSLRGIPNQLNQDKPALLRHCKVRQPPAYKKGNPHTRNSIKPSSHNGPSHDIFEKLQT
VSAGNVQNEEYPIRPSTLNSRQSSLAPQSQPHDFVFSPHNSGRPMELQIPTPPLPSYCST
NVCRCCQHHSHIQYSPLNSWQGANTVGSIQDVQSEALQKHSLFHPSGCPALYCNAFCSSS
SPIALRPQGDMGSCSPHSNIEPSPVARPPSHMDLCNPQPCTVCMHTPKTESDNGMMGLSP
DAYRFLTEQDRQLRLLQAQIQRLLEAQSLMPCSPKTTAVEDTVQAGRQMELVSVEAQSSP
GLHMRKGVSIAVSTGASLFWNAAGEDQEPDSQMKQDDTKISSEDMNFSVDINNEVTSLPG
SASSLKAVDIPSFEESNIAVEEEFNQPLSVSNSSLVVRKEPDVPVFFPSGQLAESVSMCL
QTGPTGGASNNSETSEEPKIEHVMQPLLHQPSDNQKIYQDLLGQVNHLLNSSSKETEQPS
TKAVIISHECTRTQNVYHTKKKTHHSRLVDKDCVLNATLKQLRSLGVKIDSPTKVKKNAH
NVDHASVLACISPEAVISGLNCMSFANVGMSGLSPNGVDLSMEANAIALKYLNENQLSQL
SVTRSNQNNCDPFSLLHINTDRSTVGLSLISPNNMSFATKKYMKRYGLLQSSDNSEDEEE
PPDNADSKSEYLLNQNLRSIPEQLGGQKEPSKNDHEIINCSNCESVGTNADTPVLRNITN
EVLQTKAKQQLTEKPAFLVKNLKPSPAVNLRTGKAEFTQHPEKENEGDITIFPESLQPSE
TLKQMNSMNSVGTFLDVKRLRQLPKLF
Target Bioclass
Other
Subcellular location
Cytoplasm, cytosol
Function
Immediate-early gene. Plays an important role in embryonic development as well as in cellular growth and proliferation; its long-term silencing affects cell survival and cell cycle distribution as well as decreases CDK1 activity correlated with reduced phosphorylation of CDK1. Plays a role as a positive regulator of the sonic hedgehog pathway, acting downstream of PTCH1. Plays an important role in the regulation of centriole duplication. Required for the onset of procentriole formation and proper mitotic progression. During procentriole formation, is essential for the correct loading of SASS6 and CENPJ to the base of the procentriole to initiate procentriole assembly. In complex with STIL acts as a modulator of PLK4-driven cytoskeletal rearrangements and directional cell motility.
Uniprot ID
Q15468
Ensemble ID
ENST00000360380.7
HGNC ID
HGNC:10879

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 8 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
Johansson_61
 Probe Info  		_(20.00)  LDD1491  [1]
NAIA_5
 Probe Info  		C752(0.98)  LDD2227  [2]
DBIA
 Probe Info  		C134(1.03)  LDD1492  [3]
4-Iodoacetamidophenylacetylene
 Probe Info  		N.A.  LDD0038  [4]
IA-alkyne
 Probe Info  		N.A.  LDD0036  [4]
NAIA_4
 Probe Info  		N.A.  LDD2226  [2]
Compound 10
 Probe Info  		C1090(0.00); C752(0.00)  LDD2216  [5]
IPM
 Probe Info  		N.A.  LDD0147  [6]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HEK-293T C134(0.97); C155(1.05)  LDD1507  [3]
 LDCM0215  AC10 HEK-293T C134(0.85); C155(0.95)  LDD1508  [3]
 LDCM0237  AC12 HEK-293T C134(0.90); C993(1.08); C155(0.97)  LDD1510  [3]
 LDCM0259  AC14 HEK-293T C155(0.87)  LDD1512  [3]
 LDCM0270  AC15 HEK-293T C134(0.92); C155(1.00)  LDD1513  [3]
 LDCM0276  AC17 HEK-293T C134(1.08); C155(1.03)  LDD1515  [3]
 LDCM0277  AC18 HEK-293T C134(0.88); C155(1.05)  LDD1516  [3]
 LDCM0279  AC2 HEK-293T C134(0.94); C155(0.91)  LDD1518  [3]
 LDCM0280  AC20 HEK-293T C134(1.03); C993(1.13); C155(0.97)  LDD1519  [3]
 LDCM0281  AC21 HEK-293T C134(0.97); C993(1.00); C155(1.01)  LDD1520  [3]
 LDCM0282  AC22 HEK-293T C155(0.80)  LDD1521  [3]
 LDCM0283  AC23 HEK-293T C134(1.05); C155(1.11)  LDD1522  [3]
 LDCM0284  AC24 HEK-293T C155(1.09)  LDD1523  [3]
 LDCM0285  AC25 HEK-293T C134(1.13); C155(0.98)  LDD1524  [3]
 LDCM0286  AC26 HEK-293T C134(0.99); C155(1.16)  LDD1525  [3]
 LDCM0288  AC28 HEK-293T C134(1.01); C993(1.22); C155(0.98)  LDD1527  [3]
 LDCM0289  AC29 HEK-293T C134(1.01); C993(1.01); C155(0.94)  LDD1528  [3]
 LDCM0291  AC30 HEK-293T C155(0.91)  LDD1530  [3]
 LDCM0292  AC31 HEK-293T C134(0.94); C155(1.05)  LDD1531  [3]
 LDCM0293  AC32 HEK-293T C155(1.07)  LDD1532  [3]
 LDCM0294  AC33 HEK-293T C134(1.07); C155(0.94)  LDD1533  [3]
 LDCM0295  AC34 HEK-293T C134(0.92); C155(0.95)  LDD1534  [3]
 LDCM0297  AC36 HEK-293T C134(1.04); C993(1.06); C155(0.88)  LDD1536  [3]
 LDCM0298  AC37 HEK-293T C134(1.00); C993(0.93); C155(0.91)  LDD1537  [3]
 LDCM0299  AC38 HEK-293T C155(1.01)  LDD1538  [3]
 LDCM0300  AC39 HEK-293T C134(0.94); C155(0.97)  LDD1539  [3]
 LDCM0301  AC4 HEK-293T C134(0.91); C993(1.17); C155(0.95)  LDD1540  [3]
 LDCM0302  AC40 HEK-293T C155(1.06)  LDD1541  [3]
 LDCM0303  AC41 HEK-293T C134(1.06); C155(1.03)  LDD1542  [3]
 LDCM0304  AC42 HEK-293T C134(0.95); C155(0.96)  LDD1543  [3]
 LDCM0306  AC44 HEK-293T C134(1.08); C993(1.12); C155(0.97)  LDD1545  [3]
 LDCM0307  AC45 HEK-293T C134(1.12); C993(1.02); C155(0.95)  LDD1546  [3]
 LDCM0308  AC46 HEK-293T C155(0.95)  LDD1547  [3]
 LDCM0309  AC47 HEK-293T C134(1.00); C155(1.07)  LDD1548  [3]
 LDCM0310  AC48 HEK-293T C155(1.00)  LDD1549  [3]
 LDCM0311  AC49 HEK-293T C134(1.06); C155(1.00)  LDD1550  [3]
 LDCM0312  AC5 HEK-293T C134(0.94); C993(1.07); C155(0.90)  LDD1551  [3]
 LDCM0313  AC50 HEK-293T C134(0.87); C155(1.07)  LDD1552  [3]
 LDCM0315  AC52 HEK-293T C134(0.98); C993(1.05); C155(0.90)  LDD1554  [3]
 LDCM0316  AC53 HEK-293T C134(1.04); C993(1.03); C155(0.94)  LDD1555  [3]
 LDCM0317  AC54 HEK-293T C155(0.90)  LDD1556  [3]
 LDCM0318  AC55 HEK-293T C134(0.98); C155(0.97)  LDD1557  [3]
 LDCM0319  AC56 HEK-293T C155(0.93)  LDD1558  [3]
 LDCM0320  AC57 HEK-293T C134(1.02); C155(1.00)  LDD1559  [3]
 LDCM0321  AC58 HEK-293T C134(0.99); C155(1.06)  LDD1560  [3]
 LDCM0323  AC6 HEK-293T C155(0.87)  LDD1562  [3]
 LDCM0324  AC60 HEK-293T C134(1.06); C993(1.02); C155(0.92)  LDD1563  [3]
 LDCM0325  AC61 HEK-293T C134(1.04); C993(1.00); C155(1.01)  LDD1564  [3]
 LDCM0326  AC62 HEK-293T C155(0.92)  LDD1565  [3]
 LDCM0327  AC63 HEK-293T C134(1.06); C155(1.03)  LDD1566  [3]
 LDCM0328  AC64 HEK-293T C155(1.06)  LDD1567  [3]
 LDCM0334  AC7 HEK-293T C134(1.02); C155(1.03)  LDD1568  [3]
 LDCM0345  AC8 HEK-293T C155(1.09)  LDD1569  [3]
 LDCM0248  AKOS034007472 HEK-293T C134(1.01); C993(0.97); C155(0.93)  LDD1511  [3]
 LDCM0356  AKOS034007680 HEK-293T C134(1.05); C155(1.03)  LDD1570  [3]
 LDCM0275  AKOS034007705 HEK-293T C155(1.08)  LDD1514  [3]
 LDCM0632  CL-Sc Hep-G2 C752(0.98)  LDD2227  [2]
 LDCM0367  CL1 HEK-293T C134(1.03); C993(1.30); C155(0.97); C109(0.85)  LDD1571  [3]
 LDCM0368  CL10 HEK-293T C155(1.12)  LDD1572  [3]
 LDCM0369  CL100 HEK-293T C134(0.98); C155(0.90)  LDD1573  [3]
 LDCM0370  CL101 HEK-293T C134(1.01); C993(1.06); C155(1.04); C109(0.97)  LDD1574  [3]
 LDCM0371  CL102 HEK-293T C134(1.02); C993(1.18); C155(0.90)  LDD1575  [3]
 LDCM0372  CL103 HEK-293T C993(0.93); C155(0.97)  LDD1576  [3]
 LDCM0373  CL104 HEK-293T C134(1.09); C155(0.96)  LDD1577  [3]
 LDCM0374  CL105 HEK-293T C134(0.91); C993(1.24); C155(0.98); C109(0.95)  LDD1578  [3]
 LDCM0375  CL106 HEK-293T C134(0.99); C993(1.07); C155(0.86)  LDD1579  [3]
 LDCM0376  CL107 HEK-293T C993(0.98); C155(0.90)  LDD1580  [3]
 LDCM0377  CL108 HEK-293T C134(0.90); C155(0.93)  LDD1581  [3]
 LDCM0378  CL109 HEK-293T C134(0.95); C993(1.18); C155(0.90); C109(0.92)  LDD1582  [3]
 LDCM0379  CL11 HEK-293T C134(0.92); C155(0.92)  LDD1583  [3]
 LDCM0380  CL110 HEK-293T C134(0.94); C993(1.26); C155(0.92)  LDD1584  [3]
 LDCM0381  CL111 HEK-293T C993(1.19); C155(1.05)  LDD1585  [3]
 LDCM0382  CL112 HEK-293T C134(0.97); C155(1.29)  LDD1586  [3]
 LDCM0383  CL113 HEK-293T C134(1.00); C993(1.04); C155(1.00); C109(1.00)  LDD1587  [3]
 LDCM0384  CL114 HEK-293T C134(1.02); C993(1.09); C155(1.06)  LDD1588  [3]
 LDCM0385  CL115 HEK-293T C993(1.04); C155(1.04)  LDD1589  [3]
 LDCM0386  CL116 HEK-293T C134(1.08); C155(1.14)  LDD1590  [3]
 LDCM0387  CL117 HEK-293T C134(1.00); C993(1.09); C155(0.84); C109(0.99)  LDD1591  [3]
 LDCM0388  CL118 HEK-293T C134(1.06); C993(1.10); C155(1.04)  LDD1592  [3]
 LDCM0389  CL119 HEK-293T C993(1.00); C155(0.90)  LDD1593  [3]
 LDCM0390  CL12 HEK-293T C155(0.87)  LDD1594  [3]
 LDCM0391  CL120 HEK-293T C134(0.93); C155(0.98)  LDD1595  [3]
 LDCM0392  CL121 HEK-293T C134(1.04); C993(0.97); C155(0.92); C109(0.81)  LDD1596  [3]
 LDCM0393  CL122 HEK-293T C134(1.01); C993(1.27); C155(1.02)  LDD1597  [3]
 LDCM0394  CL123 HEK-293T C993(1.44); C155(0.85)  LDD1598  [3]
 LDCM0395  CL124 HEK-293T C134(1.05); C155(0.87)  LDD1599  [3]
 LDCM0396  CL125 HEK-293T C134(0.93); C993(1.07); C155(0.97); C109(0.89)  LDD1600  [3]
 LDCM0397  CL126 HEK-293T C134(0.97); C993(1.11); C155(1.05)  LDD1601  [3]
 LDCM0398  CL127 HEK-293T C993(1.05); C155(0.96)  LDD1602  [3]
 LDCM0399  CL128 HEK-293T C134(1.09); C155(1.00)  LDD1603  [3]
 LDCM0400  CL13 HEK-293T C134(1.03); C993(1.18); C155(0.97); C109(0.89)  LDD1604  [3]
 LDCM0401  CL14 HEK-293T C134(1.07); C993(1.15); C155(0.92)  LDD1605  [3]
 LDCM0402  CL15 HEK-293T C993(1.70); C155(0.79)  LDD1606  [3]
 LDCM0403  CL16 HEK-293T C134(1.06); C155(1.05)  LDD1607  [3]
 LDCM0404  CL17 HEK-293T C134(1.06); C155(0.93)  LDD1608  [3]
 LDCM0405  CL18 HEK-293T C134(0.90); C155(0.83)  LDD1609  [3]
 LDCM0407  CL2 HEK-293T C134(0.97); C993(1.24); C155(1.03)  LDD1611  [3]
 LDCM0408  CL20 HEK-293T C134(1.00); C993(1.17); C155(0.97)  LDD1612  [3]
 LDCM0409  CL21 HEK-293T C134(0.95); C993(1.69); C155(0.92)  LDD1613  [3]
 LDCM0410  CL22 HEK-293T C155(1.14)  LDD1614  [3]
 LDCM0411  CL23 HEK-293T C134(0.91); C155(0.94)  LDD1615  [3]
 LDCM0412  CL24 HEK-293T C155(0.89)  LDD1616  [3]
 LDCM0413  CL25 HEK-293T C134(0.90); C993(1.24); C155(0.89); C109(0.81)  LDD1617  [3]
 LDCM0414  CL26 HEK-293T C134(1.02); C993(1.12); C155(0.90)  LDD1618  [3]
 LDCM0415  CL27 HEK-293T C993(0.99); C155(0.91)  LDD1619  [3]
 LDCM0416  CL28 HEK-293T C134(0.89); C155(0.97)  LDD1620  [3]
 LDCM0417  CL29 HEK-293T C134(1.04); C155(0.90)  LDD1621  [3]
 LDCM0418  CL3 HEK-293T C993(1.06); C155(0.85)  LDD1622  [3]
 LDCM0419  CL30 HEK-293T C134(0.95); C155(0.93)  LDD1623  [3]
 LDCM0421  CL32 HEK-293T C134(1.07); C993(1.23); C155(0.92)  LDD1625  [3]
 LDCM0422  CL33 HEK-293T C134(1.03); C993(2.12); C155(0.83)  LDD1626  [3]
 LDCM0423  CL34 HEK-293T C155(1.01)  LDD1627  [3]
 LDCM0424  CL35 HEK-293T C134(1.04); C155(0.90)  LDD1628  [3]
 LDCM0425  CL36 HEK-293T C155(0.96)  LDD1629  [3]
 LDCM0426  CL37 HEK-293T C134(0.85); C993(1.02); C155(0.92); C109(0.81)  LDD1630  [3]
 LDCM0428  CL39 HEK-293T C993(0.93); C155(0.93)  LDD1632  [3]
 LDCM0429  CL4 HEK-293T C134(1.05); C155(0.92)  LDD1633  [3]
 LDCM0430  CL40 HEK-293T C134(0.92); C155(0.96)  LDD1634  [3]
 LDCM0431  CL41 HEK-293T C134(1.10); C155(0.89)  LDD1635  [3]
 LDCM0432  CL42 HEK-293T C134(0.92); C155(1.06)  LDD1636  [3]
 LDCM0434  CL44 HEK-293T C134(1.05); C993(1.15); C155(0.85)  LDD1638  [3]
 LDCM0435  CL45 HEK-293T C134(1.05); C993(1.38); C155(0.86)  LDD1639  [3]
 LDCM0436  CL46 HEK-293T C155(0.94)  LDD1640  [3]
 LDCM0437  CL47 HEK-293T C134(0.94); C155(0.90)  LDD1641  [3]
 LDCM0438  CL48 HEK-293T C155(0.89)  LDD1642  [3]
 LDCM0439  CL49 HEK-293T C134(0.93); C993(1.05); C155(0.93); C109(0.99)  LDD1643  [3]
 LDCM0440  CL5 HEK-293T C134(1.10); C155(1.05)  LDD1644  [3]
 LDCM0441  CL50 HEK-293T C134(1.08); C993(1.34); C155(0.92)  LDD1645  [3]
 LDCM0443  CL52 HEK-293T C134(0.90); C155(0.97)  LDD1646  [3]
 LDCM0444  CL53 HEK-293T C134(1.15); C155(0.94)  LDD1647  [3]
 LDCM0445  CL54 HEK-293T C134(0.87); C155(0.84)  LDD1648  [3]
 LDCM0447  CL56 HEK-293T C134(1.08); C993(1.32); C155(0.89)  LDD1650  [3]
 LDCM0448  CL57 HEK-293T C134(1.05); C993(1.52); C155(0.96)  LDD1651  [3]
 LDCM0449  CL58 HEK-293T C155(0.96)  LDD1652  [3]
 LDCM0450  CL59 HEK-293T C134(0.96); C155(0.89)  LDD1653  [3]
 LDCM0451  CL6 HEK-293T C134(0.90); C155(0.91)  LDD1654  [3]
 LDCM0452  CL60 HEK-293T C155(0.91)  LDD1655  [3]
 LDCM0453  CL61 HEK-293T C134(0.92); C993(0.90); C155(0.94); C109(1.08)  LDD1656  [3]
 LDCM0454  CL62 HEK-293T C134(1.10); C993(1.06); C155(0.81)  LDD1657  [3]
 LDCM0455  CL63 HEK-293T C993(0.96); C155(0.92)  LDD1658  [3]
 LDCM0456  CL64 HEK-293T C134(0.99); C155(0.90)  LDD1659  [3]
 LDCM0457  CL65 HEK-293T C134(1.02); C155(0.93)  LDD1660  [3]
 LDCM0458  CL66 HEK-293T C134(0.94); C155(0.91)  LDD1661  [3]
 LDCM0460  CL68 HEK-293T C134(1.01); C993(1.55); C155(0.83)  LDD1663  [3]
 LDCM0461  CL69 HEK-293T C134(1.15); C993(1.39); C155(0.85)  LDD1664  [3]
 LDCM0463  CL70 HEK-293T C155(0.98)  LDD1666  [3]
 LDCM0464  CL71 HEK-293T C134(1.10); C155(0.92)  LDD1667  [3]
 LDCM0465  CL72 HEK-293T C155(1.02)  LDD1668  [3]
 LDCM0466  CL73 HEK-293T C134(0.96); C993(1.18); C155(0.93); C109(0.87)  LDD1669  [3]
 LDCM0467  CL74 HEK-293T C134(1.01); C993(1.06); C155(0.97)  LDD1670  [3]
 LDCM0469  CL76 HEK-293T C134(0.95); C155(0.88)  LDD1672  [3]
 LDCM0470  CL77 HEK-293T C134(1.06); C155(0.84)  LDD1673  [3]
 LDCM0471  CL78 HEK-293T C134(0.90); C155(0.88)  LDD1674  [3]
 LDCM0473  CL8 HEK-293T C134(0.92); C993(2.08); C155(0.87)  LDD1676  [3]
 LDCM0474  CL80 HEK-293T C134(1.12); C993(1.10); C155(0.79)  LDD1677  [3]
 LDCM0475  CL81 HEK-293T C134(1.05); C993(1.05); C155(0.81)  LDD1678  [3]
 LDCM0476  CL82 HEK-293T C155(0.95)  LDD1679  [3]
 LDCM0477  CL83 HEK-293T C134(0.91); C155(0.89)  LDD1680  [3]
 LDCM0478  CL84 HEK-293T C155(1.00)  LDD1681  [3]
 LDCM0479  CL85 HEK-293T C134(0.87); C993(1.05); C155(1.05); C109(0.95)  LDD1682  [3]
 LDCM0480  CL86 HEK-293T C134(0.93); C993(1.12); C155(0.96)  LDD1683  [3]
 LDCM0481  CL87 HEK-293T C993(1.19); C155(0.93)  LDD1684  [3]
 LDCM0482  CL88 HEK-293T C134(1.02); C155(0.90)  LDD1685  [3]
 LDCM0483  CL89 HEK-293T C134(1.08); C155(0.87)  LDD1686  [3]
 LDCM0484  CL9 HEK-293T C134(0.98); C993(1.18); C155(0.90)  LDD1687  [3]
 LDCM0485  CL90 HEK-293T C134(0.88); C155(0.84)  LDD1688  [3]
 LDCM0487  CL92 HEK-293T C134(1.05); C993(1.59); C155(0.90)  LDD1690  [3]
 LDCM0488  CL93 HEK-293T C134(1.14); C993(1.33); C155(0.88)  LDD1691  [3]
 LDCM0489  CL94 HEK-293T C155(1.04)  LDD1692  [3]
 LDCM0490  CL95 HEK-293T C134(0.91); C155(0.89)  LDD1693  [3]
 LDCM0491  CL96 HEK-293T C155(0.99)  LDD1694  [3]
 LDCM0492  CL97 HEK-293T C134(0.93); C993(1.10); C155(0.97); C109(0.93)  LDD1695  [3]
 LDCM0493  CL98 HEK-293T C134(0.87); C993(1.12); C155(0.87)  LDD1696  [3]
 LDCM0494  CL99 HEK-293T C993(1.05); C155(0.97)  LDD1697  [3]
 LDCM0495  E2913 HEK-293T C993(1.16); C155(0.93)  LDD1698  [3]
 LDCM0575  Fragment13 Ramos C134(0.91)  LDD2192  [7]
 LDCM0580  Fragment21 Ramos C134(1.01)  LDD2195  [7]
 LDCM0582  Fragment23 Ramos C134(0.98)  LDD2196  [7]
 LDCM0586  Fragment28 Ramos C134(0.71)  LDD2198  [7]
 LDCM0589  Fragment31 Ramos C134(1.08)  LDD2200  [7]
 LDCM0468  Fragment33 HEK-293T C993(1.07); C155(0.94)  LDD1671  [3]
 LDCM0596  Fragment38 Ramos C134(1.73)  LDD2203  [7]
 LDCM0427  Fragment51 HEK-293T C134(1.06); C993(1.03); C155(1.04)  LDD1631  [3]
 LDCM0617  Fragment63-S Jurkat _(20.00)  LDD1491  [1]
 LDCM0022  KB02 HEK-293T C134(1.03)  LDD1492  [3]
 LDCM0023  KB03 HEK-293T C134(1.07)  LDD1497  [3]
 LDCM0024  KB05 HEK-293T C134(0.98)  LDD1502  [3]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Serine/threonine-protein kinase PLK4 (PLK4) Ser/Thr protein kinase family O00444
Other
Click To Hide/Show 3 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Centromere protein J (CENPJ) TCP10 family Q9HC77
SCL-interrupting locus protein (STIL) . Q15468
Spindle assembly abnormal protein 6 homolog (SASS6) . Q6UVJ0

References

1 Proteome-wide covalent ligand discovery in native biological systems. Nature. 2016 Jun 23;534(7608):570-4. doi: 10.1038/nature18002. Epub 2016 Jun 15.
2 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
3 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
4 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
5 Multiplexed CuAAC Suzuki-Miyaura Labeling for Tandem Activity-Based Chemoproteomic Profiling. Anal Chem. 2021 Feb 2;93(4):2610-2618. doi: 10.1021/acs.analchem.0c04726. Epub 2021 Jan 20.
Mass spectrometry data entry: PXD022279
6 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
7 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578