Details of the Target

General Information of Target

Target ID LDTP05858
Target Name Origin recognition complex subunit 2 (ORC2)
Gene Name ORC2
Gene ID 4999
Synonyms
ORC2L; Origin recognition complex subunit 2
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MSKPELKEDKMLEVHFVGDDDVLNHILDREGGAKLKKERAQLLVNPKKIIKKPEYDLEED
DQEVLKDQNYVEIMGRDVQESLKNGSATGGGNKVYSFQNRKHSEKMAKLASELAKTPQKS
VSFSLKNDPEITINVPQSSKGHSASDKVQPKNNDKSEFLSTAPRSLRKRLIVPRSHSDSE
SEYSASNSEDDEGVAQEHEEDTNAVIFSQKIQAQNRVVSAPVGKETPSKRMKRDKTSDLV
EEYFEAHSSSKVLTSDRTLQKLKRAKLDQQTLRNLLSKVSPSFSAELKQLNQQYEKLFHK
WMLQLHLGFNIVLYGLGSKRDLLERFRTTMLQDSIHVVINGFFPGISVKSVLNSITEEVL
DHMGTFRSILDQLDWIVNKFKEDSSLELFLLIHNLDSQMLRGEKSQQIIGQLSSLHNIYL
IASIDHLNAPLMWDHAKQSLFNWLWYETTTYSPYTEETSYENSLLVKQSGSLPLSSLTHV
LRSLTPNARGIFRLLIKYQLDNQDNPSYIGLSFQDFYQQCREAFLVNSDLTLRAQLTEFR
DHKLIRTKKGTDGVEYLLIPVDNGTLTDFLEKEEEEA
Target Bioclass
Other
Family
ORC2 family
Subcellular location
Nucleus
Function
Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent. The specific DNA sequences that define origins of replication have not been identified yet. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication. Binds histone H3 and H4 trimethylation marks H3K9me3, H3K20me3 and H4K27me3. Stabilizes LRWD1, by protecting it from ubiquitin-mediated proteasomal degradation. Also stabilizes ORC3.
Uniprot ID
Q13416
Ensemble ID
ENST00000234296.7
HGNC ID
HGNC:8488

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 5 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
STPyne
 Probe Info  		K155(6.25)  LDD0277  [1]
IA-alkyne
 Probe Info  		C520(5.45)  LDD2157  [2]
Probe 1
 Probe Info  		Y55(36.52); Y95(21.32)  LDD3495  [3]
Acrolein
 Probe Info  		N.A.  LDD0225  [4]
DBIA
 Probe Info  		C520(0.54)  LDD0532  [5]
PAL-AfBPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
VE-P
 Probe Info  		N.A.  LDD0396  [6]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 PaTu 8988t C520(0.78)  LDD1093  [5]
 LDCM0215  AC10 HCT 116 C520(0.54)  LDD0532  [5]
 LDCM0216  AC100 PaTu 8988t C520(0.58)  LDD1095  [5]
 LDCM0217  AC101 PaTu 8988t C520(0.49)  LDD1096  [5]
 LDCM0218  AC102 PaTu 8988t C520(0.64)  LDD1097  [5]
 LDCM0219  AC103 PaTu 8988t C520(1.78)  LDD1098  [5]
 LDCM0220  AC104 PaTu 8988t C520(0.50)  LDD1099  [5]
 LDCM0221  AC105 PaTu 8988t C520(0.82)  LDD1100  [5]
 LDCM0222  AC106 PaTu 8988t C520(0.46)  LDD1101  [5]
 LDCM0223  AC107 PaTu 8988t C520(0.57)  LDD1102  [5]
 LDCM0224  AC108 PaTu 8988t C520(0.63)  LDD1103  [5]
 LDCM0225  AC109 PaTu 8988t C520(0.44)  LDD1104  [5]
 LDCM0226  AC11 HCT 116 C520(0.62)  LDD0543  [5]
 LDCM0227  AC110 PaTu 8988t C520(0.34)  LDD1106  [5]
 LDCM0228  AC111 PaTu 8988t C520(0.32)  LDD1107  [5]
 LDCM0229  AC112 PaTu 8988t C520(0.69)  LDD1108  [5]
 LDCM0230  AC113 HCT 116 C520(1.46)  LDD0547  [5]
 LDCM0231  AC114 HCT 116 C520(0.86)  LDD0548  [5]
 LDCM0232  AC115 HCT 116 C520(1.28)  LDD0549  [5]
 LDCM0233  AC116 HCT 116 C520(0.97)  LDD0550  [5]
 LDCM0234  AC117 HCT 116 C520(1.40)  LDD0551  [5]
 LDCM0235  AC118 HCT 116 C520(1.06)  LDD0552  [5]
 LDCM0236  AC119 HCT 116 C520(1.03)  LDD0553  [5]
 LDCM0237  AC12 HCT 116 C520(0.75)  LDD0554  [5]
 LDCM0238  AC120 HCT 116 C520(0.89)  LDD0555  [5]
 LDCM0239  AC121 HCT 116 C520(1.14)  LDD0556  [5]
 LDCM0240  AC122 HCT 116 C520(1.09)  LDD0557  [5]
 LDCM0241  AC123 HCT 116 C520(1.28)  LDD0558  [5]
 LDCM0242  AC124 HCT 116 C520(0.87)  LDD0559  [5]
 LDCM0243  AC125 HCT 116 C520(0.95)  LDD0560  [5]
 LDCM0244  AC126 HCT 116 C520(0.97)  LDD0561  [5]
 LDCM0245  AC127 HCT 116 C520(0.91)  LDD0562  [5]
 LDCM0246  AC128 PaTu 8988t C520(0.79)  LDD1125  [5]
 LDCM0247  AC129 PaTu 8988t C520(0.68)  LDD1126  [5]
 LDCM0249  AC130 PaTu 8988t C520(0.84)  LDD1128  [5]
 LDCM0250  AC131 PaTu 8988t C520(0.77)  LDD1129  [5]
 LDCM0251  AC132 PaTu 8988t C520(0.85)  LDD1130  [5]
 LDCM0252  AC133 PaTu 8988t C520(0.84)  LDD1131  [5]
 LDCM0253  AC134 PaTu 8988t C520(0.71)  LDD1132  [5]
 LDCM0254  AC135 PaTu 8988t C520(0.71)  LDD1133  [5]
 LDCM0255  AC136 PaTu 8988t C520(0.78)  LDD1134  [5]
 LDCM0256  AC137 PaTu 8988t C520(0.66)  LDD1135  [5]
 LDCM0257  AC138 PaTu 8988t C520(0.62)  LDD1136  [5]
 LDCM0258  AC139 PaTu 8988t C520(0.68)  LDD1137  [5]
 LDCM0259  AC14 HCT 116 C520(0.57)  LDD0576  [5]
 LDCM0260  AC140 PaTu 8988t C520(0.96)  LDD1139  [5]
 LDCM0261  AC141 PaTu 8988t C520(0.86)  LDD1140  [5]
 LDCM0262  AC142 PaTu 8988t C520(0.79)  LDD1141  [5]
 LDCM0263  AC143 PaTu 8988t C520(0.91)  LDD1142  [5]
 LDCM0264  AC144 PaTu 8988t C520(0.80)  LDD1143  [5]
 LDCM0265  AC145 PaTu 8988t C520(0.72)  LDD1144  [5]
 LDCM0266  AC146 PaTu 8988t C520(0.69)  LDD1145  [5]
 LDCM0267  AC147 PaTu 8988t C520(1.11)  LDD1146  [5]
 LDCM0268  AC148 PaTu 8988t C520(0.66)  LDD1147  [5]
 LDCM0269  AC149 PaTu 8988t C520(0.64)  LDD1148  [5]
 LDCM0270  AC15 HCT 116 C520(0.62)  LDD0587  [5]
 LDCM0271  AC150 PaTu 8988t C520(0.55)  LDD1150  [5]
 LDCM0272  AC151 PaTu 8988t C520(0.46)  LDD1151  [5]
 LDCM0273  AC152 PaTu 8988t C520(0.69)  LDD1152  [5]
 LDCM0274  AC153 PaTu 8988t C520(0.59)  LDD1153  [5]
 LDCM0621  AC154 PaTu 8988t C520(0.60)  LDD2166  [5]
 LDCM0622  AC155 PaTu 8988t C520(0.49)  LDD2167  [5]
 LDCM0623  AC156 PaTu 8988t C520(0.67)  LDD2168  [5]
 LDCM0624  AC157 PaTu 8988t C520(0.54)  LDD2169  [5]
 LDCM0276  AC17 HCT 116 C520(1.00)  LDD0593  [5]
 LDCM0277  AC18 HCT 116 C520(0.59)  LDD0594  [5]
 LDCM0278  AC19 HCT 116 C520(0.76)  LDD0595  [5]
 LDCM0279  AC2 PaTu 8988t C520(0.85)  LDD1158  [5]
 LDCM0280  AC20 HCT 116 C520(0.92)  LDD0597  [5]
 LDCM0281  AC21 HCT 116 C520(0.93)  LDD0598  [5]
 LDCM0282  AC22 HCT 116 C520(1.15)  LDD0599  [5]
 LDCM0283  AC23 HCT 116 C520(0.88)  LDD0600  [5]
 LDCM0284  AC24 HCT 116 C520(1.06)  LDD0601  [5]
 LDCM0290  AC3 PaTu 8988t C520(0.77)  LDD1169  [5]
 LDCM0296  AC35 PaTu 8988t C520(0.63)  LDD1175  [5]
 LDCM0297  AC36 PaTu 8988t C520(0.44)  LDD1176  [5]
 LDCM0298  AC37 PaTu 8988t C520(0.55)  LDD1177  [5]
 LDCM0299  AC38 PaTu 8988t C520(0.53)  LDD1178  [5]
 LDCM0300  AC39 PaTu 8988t C520(0.54)  LDD1179  [5]
 LDCM0301  AC4 PaTu 8988t C520(1.09)  LDD1180  [5]
 LDCM0302  AC40 PaTu 8988t C520(0.44)  LDD1181  [5]
 LDCM0303  AC41 PaTu 8988t C520(0.59)  LDD1182  [5]
 LDCM0304  AC42 PaTu 8988t C520(0.70)  LDD1183  [5]
 LDCM0305  AC43 PaTu 8988t C520(0.76)  LDD1184  [5]
 LDCM0306  AC44 PaTu 8988t C520(0.58)  LDD1185  [5]
 LDCM0307  AC45 PaTu 8988t C520(0.77)  LDD1186  [5]
 LDCM0308  AC46 HCT 116 C520(0.83)  LDD0625  [5]
 LDCM0309  AC47 HCT 116 C520(1.02)  LDD0626  [5]
 LDCM0310  AC48 HCT 116 C520(0.83)  LDD0627  [5]
 LDCM0311  AC49 HCT 116 C520(0.66)  LDD0628  [5]
 LDCM0312  AC5 PaTu 8988t C520(0.74)  LDD1191  [5]
 LDCM0313  AC50 HCT 116 C520(0.50)  LDD0630  [5]
 LDCM0314  AC51 HCT 116 C520(1.66)  LDD0631  [5]
 LDCM0315  AC52 HCT 116 C520(0.78)  LDD0632  [5]
 LDCM0316  AC53 HCT 116 C520(0.54)  LDD0633  [5]
 LDCM0317  AC54 HCT 116 C520(0.68)  LDD0634  [5]
 LDCM0318  AC55 HCT 116 C520(0.52)  LDD0635  [5]
 LDCM0319  AC56 HCT 116 C520(0.57)  LDD0636  [5]
 LDCM0320  AC57 HCT 116 C520(0.17)  LDD0637  [5]
 LDCM0321  AC58 HCT 116 C520(0.19)  LDD0638  [5]
 LDCM0322  AC59 HCT 116 C520(0.19)  LDD0639  [5]
 LDCM0323  AC6 HCT 116 C520(0.50)  LDD0640  [5]
 LDCM0324  AC60 HCT 116 C520(0.21)  LDD0641  [5]
 LDCM0325  AC61 HCT 116 C520(0.21)  LDD0642  [5]
 LDCM0326  AC62 HCT 116 C520(0.18)  LDD0643  [5]
 LDCM0327  AC63 HCT 116 C520(0.17)  LDD0644  [5]
 LDCM0328  AC64 HCT 116 C520(0.22)  LDD0645  [5]
 LDCM0329  AC65 HCT 116 C520(0.21)  LDD0646  [5]
 LDCM0330  AC66 HCT 116 C520(0.23)  LDD0647  [5]
 LDCM0331  AC67 HCT 116 C520(0.13)  LDD0648  [5]
 LDCM0332  AC68 HCT 116 C520(0.45)  LDD0649  [5]
 LDCM0333  AC69 HCT 116 C520(0.40)  LDD0650  [5]
 LDCM0334  AC7 HCT 116 C520(0.90)  LDD0651  [5]
 LDCM0335  AC70 HCT 116 C520(0.34)  LDD0652  [5]
 LDCM0336  AC71 HCT 116 C520(0.45)  LDD0653  [5]
 LDCM0337  AC72 HCT 116 C520(0.79)  LDD0654  [5]
 LDCM0338  AC73 HCT 116 C520(0.44)  LDD0655  [5]
 LDCM0339  AC74 HCT 116 C520(0.53)  LDD0656  [5]
 LDCM0340  AC75 HCT 116 C520(0.44)  LDD0657  [5]
 LDCM0341  AC76 HCT 116 C520(0.50)  LDD0658  [5]
 LDCM0342  AC77 HCT 116 C520(0.40)  LDD0659  [5]
 LDCM0343  AC78 HCT 116 C520(0.81)  LDD0660  [5]
 LDCM0344  AC79 HCT 116 C520(0.63)  LDD0661  [5]
 LDCM0345  AC8 HCT 116 C520(0.85)  LDD0662  [5]
 LDCM0346  AC80 HCT 116 C520(0.42)  LDD0663  [5]
 LDCM0347  AC81 HCT 116 C520(0.94)  LDD0664  [5]
 LDCM0348  AC82 HCT 116 C520(0.46)  LDD0665  [5]
 LDCM0349  AC83 HCT 116 C520(0.60)  LDD0666  [5]
 LDCM0350  AC84 HCT 116 C520(0.56)  LDD0667  [5]
 LDCM0351  AC85 HCT 116 C520(0.78)  LDD0668  [5]
 LDCM0352  AC86 HCT 116 C520(0.74)  LDD0669  [5]
 LDCM0353  AC87 HCT 116 C520(0.72)  LDD0670  [5]
 LDCM0354  AC88 HCT 116 C520(0.82)  LDD0671  [5]
 LDCM0355  AC89 HCT 116 C520(0.69)  LDD0672  [5]
 LDCM0357  AC90 HCT 116 C520(0.92)  LDD0674  [5]
 LDCM0358  AC91 HCT 116 C520(0.86)  LDD0675  [5]
 LDCM0359  AC92 HCT 116 C520(0.57)  LDD0676  [5]
 LDCM0360  AC93 HCT 116 C520(0.72)  LDD0677  [5]
 LDCM0361  AC94 HCT 116 C520(0.90)  LDD0678  [5]
 LDCM0362  AC95 HCT 116 C520(0.87)  LDD0679  [5]
 LDCM0363  AC96 HCT 116 C520(0.98)  LDD0680  [5]
 LDCM0364  AC97 HCT 116 C520(0.62)  LDD0681  [5]
 LDCM0365  AC98 PaTu 8988t C520(0.67)  LDD1244  [5]
 LDCM0366  AC99 PaTu 8988t C520(0.57)  LDD1245  [5]
 LDCM0248  AKOS034007472 HCT 116 C520(0.96)  LDD0565  [5]
 LDCM0356  AKOS034007680 HCT 116 C520(0.58)  LDD0673  [5]
 LDCM0275  AKOS034007705 HCT 116 C520(0.43)  LDD0592  [5]
 LDCM0367  CL1 PaTu 8988t C520(0.76)  LDD1246  [5]
 LDCM0368  CL10 PaTu 8988t C520(0.54)  LDD1247  [5]
 LDCM0369  CL100 PaTu 8988t C520(0.82)  LDD1248  [5]
 LDCM0370  CL101 HCT 116 C520(0.56)  LDD0687  [5]
 LDCM0371  CL102 HCT 116 C520(1.22)  LDD0688  [5]
 LDCM0372  CL103 HCT 116 C520(1.06)  LDD0689  [5]
 LDCM0373  CL104 HCT 116 C520(0.85)  LDD0690  [5]
 LDCM0374  CL105 HCT 116 C520(0.61)  LDD0691  [5]
 LDCM0375  CL106 HCT 116 C520(0.42)  LDD0692  [5]
 LDCM0376  CL107 HCT 116 C520(0.52)  LDD0693  [5]
 LDCM0377  CL108 HCT 116 C520(0.61)  LDD0694  [5]
 LDCM0378  CL109 HCT 116 C520(0.59)  LDD0695  [5]
 LDCM0379  CL11 PaTu 8988t C520(0.75)  LDD1258  [5]
 LDCM0380  CL110 HCT 116 C520(0.57)  LDD0697  [5]
 LDCM0381  CL111 HCT 116 C520(0.88)  LDD0698  [5]
 LDCM0387  CL117 PaTu 8988t C520(0.68)  LDD1266  [5]
 LDCM0388  CL118 PaTu 8988t C520(1.42)  LDD1267  [5]
 LDCM0389  CL119 PaTu 8988t C520(0.57)  LDD1268  [5]
 LDCM0390  CL12 PaTu 8988t C520(0.59)  LDD1269  [5]
 LDCM0391  CL120 PaTu 8988t C520(0.47)  LDD1270  [5]
 LDCM0392  CL121 HCT 116 C520(0.90)  LDD0709  [5]
 LDCM0393  CL122 HCT 116 C520(0.73)  LDD0710  [5]
 LDCM0394  CL123 HCT 116 C520(0.70)  LDD0711  [5]
 LDCM0395  CL124 HCT 116 C520(0.61)  LDD0712  [5]
 LDCM0396  CL125 HCT 116 C520(1.74)  LDD0713  [5]
 LDCM0397  CL126 HCT 116 C520(0.38)  LDD0714  [5]
 LDCM0398  CL127 HCT 116 C520(0.27)  LDD0715  [5]
 LDCM0399  CL128 HCT 116 C520(0.17)  LDD0716  [5]
 LDCM0400  CL13 PaTu 8988t C520(0.50)  LDD1279  [5]
 LDCM0401  CL14 PaTu 8988t C520(0.50)  LDD1280  [5]
 LDCM0402  CL15 PaTu 8988t C520(0.56)  LDD1281  [5]
 LDCM0403  CL16 PaTu 8988t C520(0.54)  LDD1282  [5]
 LDCM0404  CL17 PaTu 8988t C520(0.38)  LDD1283  [5]
 LDCM0405  CL18 PaTu 8988t C520(0.58)  LDD1284  [5]
 LDCM0406  CL19 PaTu 8988t C520(0.46)  LDD1285  [5]
 LDCM0407  CL2 PaTu 8988t C520(0.60)  LDD1286  [5]
 LDCM0408  CL20 PaTu 8988t C520(0.47)  LDD1287  [5]
 LDCM0409  CL21 PaTu 8988t C520(0.43)  LDD1288  [5]
 LDCM0410  CL22 PaTu 8988t C520(0.64)  LDD1289  [5]
 LDCM0411  CL23 PaTu 8988t C520(0.65)  LDD1290  [5]
 LDCM0412  CL24 PaTu 8988t C520(0.50)  LDD1291  [5]
 LDCM0413  CL25 PaTu 8988t C520(0.61)  LDD1292  [5]
 LDCM0414  CL26 PaTu 8988t C520(0.64)  LDD1293  [5]
 LDCM0415  CL27 PaTu 8988t C520(0.93)  LDD1294  [5]
 LDCM0416  CL28 PaTu 8988t C520(0.56)  LDD1295  [5]
 LDCM0417  CL29 PaTu 8988t C520(0.52)  LDD1296  [5]
 LDCM0418  CL3 PaTu 8988t C520(0.63)  LDD1297  [5]
 LDCM0419  CL30 PaTu 8988t C520(0.59)  LDD1298  [5]
 LDCM0420  CL31 PaTu 8988t C520(0.89)  LDD1299  [5]
 LDCM0421  CL32 PaTu 8988t C520(0.92)  LDD1300  [5]
 LDCM0422  CL33 PaTu 8988t C520(0.54)  LDD1301  [5]
 LDCM0423  CL34 PaTu 8988t C520(0.59)  LDD1302  [5]
 LDCM0424  CL35 PaTu 8988t C520(0.58)  LDD1303  [5]
 LDCM0425  CL36 PaTu 8988t C520(0.71)  LDD1304  [5]
 LDCM0426  CL37 PaTu 8988t C520(0.59)  LDD1305  [5]
 LDCM0428  CL39 PaTu 8988t C520(0.68)  LDD1307  [5]
 LDCM0429  CL4 PaTu 8988t C520(0.75)  LDD1308  [5]
 LDCM0430  CL40 PaTu 8988t C520(0.75)  LDD1309  [5]
 LDCM0431  CL41 PaTu 8988t C520(0.61)  LDD1310  [5]
 LDCM0432  CL42 PaTu 8988t C520(0.52)  LDD1311  [5]
 LDCM0433  CL43 PaTu 8988t C520(0.53)  LDD1312  [5]
 LDCM0434  CL44 PaTu 8988t C520(0.54)  LDD1313  [5]
 LDCM0435  CL45 PaTu 8988t C520(0.76)  LDD1314  [5]
 LDCM0440  CL5 PaTu 8988t C520(0.52)  LDD1319  [5]
 LDCM0451  CL6 PaTu 8988t C520(0.59)  LDD1330  [5]
 LDCM0453  CL61 PaTu 8988t C520(0.82)  LDD1332  [5]
 LDCM0454  CL62 PaTu 8988t C520(0.74)  LDD1333  [5]
 LDCM0455  CL63 PaTu 8988t C520(0.79)  LDD1334  [5]
 LDCM0456  CL64 PaTu 8988t C520(0.84)  LDD1335  [5]
 LDCM0457  CL65 PaTu 8988t C520(0.74)  LDD1336  [5]
 LDCM0458  CL66 PaTu 8988t C520(0.63)  LDD1337  [5]
 LDCM0459  CL67 PaTu 8988t C520(0.66)  LDD1338  [5]
 LDCM0460  CL68 PaTu 8988t C520(0.61)  LDD1339  [5]
 LDCM0461  CL69 PaTu 8988t C520(0.57)  LDD1340  [5]
 LDCM0462  CL7 PaTu 8988t C520(0.52)  LDD1341  [5]
 LDCM0463  CL70 PaTu 8988t C520(0.70)  LDD1342  [5]
 LDCM0464  CL71 PaTu 8988t C520(0.90)  LDD1343  [5]
 LDCM0465  CL72 PaTu 8988t C520(1.12)  LDD1344  [5]
 LDCM0466  CL73 PaTu 8988t C520(0.60)  LDD1345  [5]
 LDCM0467  CL74 PaTu 8988t C520(0.80)  LDD1346  [5]
 LDCM0469  CL76 PaTu 8988t C520(0.65)  LDD1348  [5]
 LDCM0470  CL77 PaTu 8988t C520(0.64)  LDD1349  [5]
 LDCM0471  CL78 PaTu 8988t C520(0.62)  LDD1350  [5]
 LDCM0472  CL79 PaTu 8988t C520(0.74)  LDD1351  [5]
 LDCM0473  CL8 PaTu 8988t C520(0.62)  LDD1352  [5]
 LDCM0474  CL80 PaTu 8988t C520(0.67)  LDD1353  [5]
 LDCM0475  CL81 PaTu 8988t C520(0.58)  LDD1354  [5]
 LDCM0476  CL82 PaTu 8988t C520(0.63)  LDD1355  [5]
 LDCM0477  CL83 PaTu 8988t C520(1.01)  LDD1356  [5]
 LDCM0478  CL84 PaTu 8988t C520(0.53)  LDD1357  [5]
 LDCM0479  CL85 PaTu 8988t C520(0.55)  LDD1358  [5]
 LDCM0480  CL86 PaTu 8988t C520(0.53)  LDD1359  [5]
 LDCM0481  CL87 PaTu 8988t C520(0.51)  LDD1360  [5]
 LDCM0482  CL88 PaTu 8988t C520(0.48)  LDD1361  [5]
 LDCM0483  CL89 PaTu 8988t C520(0.51)  LDD1362  [5]
 LDCM0484  CL9 PaTu 8988t C520(0.70)  LDD1363  [5]
 LDCM0485  CL90 PaTu 8988t C520(0.44)  LDD1364  [5]
 LDCM0486  CL91 PaTu 8988t C520(0.97)  LDD1365  [5]
 LDCM0487  CL92 PaTu 8988t C520(0.73)  LDD1366  [5]
 LDCM0488  CL93 PaTu 8988t C520(0.81)  LDD1367  [5]
 LDCM0489  CL94 PaTu 8988t C520(0.65)  LDD1368  [5]
 LDCM0490  CL95 PaTu 8988t C520(0.73)  LDD1369  [5]
 LDCM0491  CL96 PaTu 8988t C520(0.88)  LDD1370  [5]
 LDCM0492  CL97 PaTu 8988t C520(0.93)  LDD1371  [5]
 LDCM0493  CL98 PaTu 8988t C520(0.68)  LDD1372  [5]
 LDCM0494  CL99 PaTu 8988t C520(0.91)  LDD1373  [5]
 LDCM0468  Fragment33 PaTu 8988t C520(0.69)  LDD1347  [5]
 LDCM0427  Fragment51 PaTu 8988t C520(0.48)  LDD1306  [5]
 LDCM0109  NEM HeLa N.A.  LDD0225  [4]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
DNA replication licensing factor MCM3 (MCM3) MCM family P25205
E3 ubiquitin-protein ligase RAD18 (RAD18) RAD18 family Q9NS91
Transcription factor
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Cell division cycle 5-like protein (CDC5L) CEF1 family Q99459
Forkhead box protein M1 (FOXM1) . Q08050
Other
Click To Hide/Show 7 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Protein MCM10 homolog (MCM10) MCM10 family Q7L590
Origin recognition complex subunit 1 (ORC1) ORC1 family Q13415
Origin recognition complex subunit 3 (ORC3) ORC3 family Q9UBD5
Origin recognition complex subunit 4 (ORC4) ORC4 family O43929
Origin recognition complex subunit 5 (ORC5) ORC5 family O43913
Protein ripply3 (RIPPLY3) Ripply family P57055
Telomeric repeat-binding factor 2 (TERF2) . Q15554

References

1 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
2 From chemoproteomic-detected amino acids to genomic coordinates: insights into precise multi-omic data integration. Mol Syst Biol. 2021 Feb;17(2):e9840. doi: 10.15252/msb.20209840.
Mass spectrometry data entry: PXD022151
3 An Azo Coupling-Based Chemoproteomic Approach to Systematically Profile the Tyrosine Reactivity in the Human Proteome. Anal Chem. 2021 Jul 27;93(29):10334-10342. doi: 10.1021/acs.analchem.1c01935. Epub 2021 Jul 12.
4 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
5 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
6 Pharmacological Targeting of Vacuolar H(+)-ATPase via Subunit V1G Combats Multidrug-Resistant Cancer. Cell Chem Biol. 2020 Nov 19;27(11):1359-1370.e8. doi: 10.1016/j.chembiol.2020.06.011. Epub 2020 Jul 9.