Details of the Target

General Information of Target

Target ID LDTP05838
Target Name RING-type E3 ubiquitin-protein ligase PPIL2 (PPIL2)
Gene Name PPIL2
Gene ID 23759
Synonyms
RING-type E3 ubiquitin-protein ligase PPIL2; EC 2.3.2.27; CYC4; Cyclophilin-60; Cyclophilin-like protein Cyp-60; Cyp60; hCyP-60; Probable inactive peptidyl-prolyl cis-trans isomerase-like 2; PPIase; Rotamase PPIL2
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MGKRQHQKDKMYITCAEYTHFYGGKKPDLPQTNFRRLPFDHCSLSLQPFVYPVCTPDGIV
FDLLNIVPWLKKYGTNPSNGEKLDGRSLIKLNFSKNSEGKYHCPVLFTVFTNNTHIVAVR
TTGNVYAYEAVEQLNIKAKNFRDLLTDEPFSRQDIITLQDPTNLDKFNVSNFYHVKNNMK
IIDPDEEKAKQDPSYYLKNTNAETRETLQELYKEFKGDEILAATMKAPEKKKVDKLNAAH
YSTGKVSASFTSTAMVPETTHEAAAIDEDVLRYQFVKKKGYVRLHTNKGDLNLELHCDLT
PKTCENFIRLCKKHYYDGTIFHRSIRNFVIQGGDPTGTGTGGESYWGKPFKDEFRPNLSH
TGRGILSMANSGPNSNRSQFFITFRSCAYLDKKHTIFGRVVGGFDVLTAMENVESDPKTD
RPKEEIRIDATTVFVDPYEEADAQIAQERKTQLKVAPETKVKSSQPQAGSQGPQTFRQGV
GKYINPAATKRAAEEEPSTSATVPMSKKKPSRGFGDFSSW
Target Bioclass
Enzyme
Family
Cyclophilin-type PPIase family, PPIL2 subfamily
Subcellular location
Nucleus
Function
Has a ubiquitin-protein ligase activity acting as an E3 ubiquitin protein ligase or as an ubiquitin-ubiquitin ligase promoting elongation of ubiquitin chains on substrates. By mediating 'Lys-48'-linked polyubiquitination of proteins could target them for proteasomal degradation. May also function as a chaperone, playing a role in transport to the cell membrane of BSG/Basigin for instance. Probable inactive PPIase with no peptidyl-prolyl cis-trans isomerase activity. As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs (Probable).
Uniprot ID
Q13356
Ensemble ID
ENST00000335025.12
HGNC ID
HGNC:9261

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
HCT116 SNV: p.A118T .
HT Deletion: p.T303PfsTer27 .
HT115 SNV: p.N33H .
JURKAT SNV: p.V53I .
KU1919 SNV: p.R272H DBIA    Probe Info 
KYSE30 SNV: p.P504R DBIA    Probe Info 
NCIH1793 SNV: p.H20L .
SUPT1 SNV: p.C387S DBIA    Probe Info 
YSCCC SNV: p.E439K DBIA    Probe Info 

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 12 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		15.00  LDD0402  [1]
Probe 1
 Probe Info  		Y73(59.73); Y212(10.82); Y483(20.44)  LDD3495  [2]
DBIA
 Probe Info  		C304(3.28)  LDD3310  [3]
AHL-Pu-1
 Probe Info  		C15(2.28)  LDD0168  [4]
4-Iodoacetamidophenylacetylene
 Probe Info  		N.A.  LDD0038  [5]
IA-alkyne
 Probe Info  		C304(0.00); C387(0.00)  LDD0036  [5]
Lodoacetamide azide
 Probe Info  		N.A.  LDD0037  [5]
IPM
 Probe Info  		N.A.  LDD0147  [6]
Phosphinate-6
 Probe Info  		N.A.  LDD0018  [7]
AOyne
 Probe Info  		15.00  LDD0443  [8]
NAIA_5
 Probe Info  		C297(0.00); C103(0.00); C387(0.00)  LDD2223  [9]
HHS-465
 Probe Info  		N.A.  LDD2240  [10]
PAL-AfBPP Probe
Click To Hide/Show 2 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
FFF probe11
 Probe Info  		5.66  LDD0472  [11]
FFF probe3
 Probe Info  		7.73  LDD0465  [11]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0025  4SU-RNA HEK-293T C15(2.28)  LDD0168  [4]
 LDCM0026  4SU-RNA+native RNA HEK-293T C15(2.33)  LDD0169  [4]
 LDCM0214  AC1 HEK-293T C304(1.16); C387(0.91); C15(1.16)  LDD1507  [12]
 LDCM0215  AC10 HEK-293T C304(1.01); C387(0.99); C15(1.00)  LDD1508  [12]
 LDCM0226  AC11 HEK-293T C304(1.02); C387(1.01); C15(0.98); C103(1.00)  LDD1509  [12]
 LDCM0237  AC12 HEK-293T C304(0.91); C387(0.95); C15(0.92)  LDD1510  [12]
 LDCM0259  AC14 HEK-293T C304(0.95); C387(0.96); C15(0.94)  LDD1512  [12]
 LDCM0270  AC15 HEK-293T C304(1.04); C387(0.97); C15(1.03)  LDD1513  [12]
 LDCM0276  AC17 HEK-293T C304(0.95); C387(0.94); C15(1.09)  LDD1515  [12]
 LDCM0277  AC18 HEK-293T C304(0.90); C387(0.94); C15(1.09)  LDD1516  [12]
 LDCM0278  AC19 HEK-293T C304(0.98); C387(0.92); C15(0.95); C103(0.88)  LDD1517  [12]
 LDCM0279  AC2 HEK-293T C304(0.96); C387(0.90); C15(1.02)  LDD1518  [12]
 LDCM0280  AC20 HEK-293T C304(0.92); C387(0.96); C15(1.00)  LDD1519  [12]
 LDCM0281  AC21 HEK-293T C304(1.00); C387(0.95); C15(0.99)  LDD1520  [12]
 LDCM0282  AC22 HEK-293T C304(0.95); C387(0.96); C15(1.06)  LDD1521  [12]
 LDCM0283  AC23 HEK-293T C304(0.93); C387(0.99); C15(1.10)  LDD1522  [12]
 LDCM0284  AC24 HEK-293T C304(1.03); C387(0.99); C15(0.92)  LDD1523  [12]
 LDCM0285  AC25 HEK-293T C304(1.06); C387(0.96); C15(1.09)  LDD1524  [12]
 LDCM0286  AC26 HEK-293T C304(0.94); C387(1.05); C15(1.01)  LDD1525  [12]
 LDCM0287  AC27 HEK-293T C304(0.91); C387(1.02); C15(0.96); C103(0.91)  LDD1526  [12]
 LDCM0288  AC28 HEK-293T C304(0.88); C387(0.98); C15(1.00)  LDD1527  [12]
 LDCM0289  AC29 HEK-293T C304(1.04); C387(1.03); C15(1.04)  LDD1528  [12]
 LDCM0290  AC3 HEK-293T C304(0.94); C387(0.94); C15(1.07); C103(0.94)  LDD1529  [12]
 LDCM0291  AC30 HEK-293T C304(0.95); C387(0.99); C15(1.02)  LDD1530  [12]
 LDCM0292  AC31 HEK-293T C304(0.96); C387(0.97); C15(1.03)  LDD1531  [12]
 LDCM0293  AC32 HEK-293T C304(0.91); C387(1.05); C15(1.00)  LDD1532  [12]
 LDCM0294  AC33 HEK-293T C304(0.97); C387(0.90); C15(1.07)  LDD1533  [12]
 LDCM0295  AC34 HEK-293T C304(1.00); C387(0.95); C15(1.01)  LDD1534  [12]
 LDCM0296  AC35 HEK-293T C304(1.00); C387(0.95); C15(0.94); C103(1.04)  LDD1535  [12]
 LDCM0297  AC36 HEK-293T C304(0.93); C387(0.90); C15(0.95)  LDD1536  [12]
 LDCM0298  AC37 HEK-293T C304(1.03); C387(0.90); C15(0.96)  LDD1537  [12]
 LDCM0299  AC38 HEK-293T C304(1.00); C387(0.94); C15(0.97)  LDD1538  [12]
 LDCM0300  AC39 HEK-293T C304(0.96); C387(0.94); C15(1.07)  LDD1539  [12]
 LDCM0301  AC4 HEK-293T C304(0.92); C387(0.94); C15(0.99)  LDD1540  [12]
 LDCM0302  AC40 HEK-293T C304(1.03); C387(0.99); C15(0.92)  LDD1541  [12]
 LDCM0303  AC41 HEK-293T C304(1.03); C387(0.89); C15(1.10)  LDD1542  [12]
 LDCM0304  AC42 HEK-293T C304(1.02); C387(0.91); C15(1.09)  LDD1543  [12]
 LDCM0305  AC43 HEK-293T C304(0.98); C387(0.99); C15(0.92); C103(1.03)  LDD1544  [12]
 LDCM0306  AC44 HEK-293T C304(0.84); C387(0.95); C15(0.98)  LDD1545  [12]
 LDCM0307  AC45 HEK-293T C304(1.02); C387(0.99); C15(1.02)  LDD1546  [12]
 LDCM0308  AC46 HEK-293T C304(1.05); C387(0.91); C15(0.95)  LDD1547  [12]
 LDCM0309  AC47 HEK-293T C304(1.02); C387(0.90); C15(1.08)  LDD1548  [12]
 LDCM0310  AC48 HEK-293T C304(0.96); C387(0.97); C15(1.00)  LDD1549  [12]
 LDCM0311  AC49 HEK-293T C304(0.90); C387(0.89); C15(1.08)  LDD1550  [12]
 LDCM0312  AC5 HEK-293T C304(0.99); C387(0.95); C15(0.99)  LDD1551  [12]
 LDCM0313  AC50 HEK-293T C304(1.10); C387(0.93); C15(1.00)  LDD1552  [12]
 LDCM0314  AC51 HEK-293T C304(0.98); C387(0.88); C15(0.97); C103(0.99)  LDD1553  [12]
 LDCM0315  AC52 HEK-293T C304(0.86); C387(0.95); C15(0.98)  LDD1554  [12]
 LDCM0316  AC53 HEK-293T C304(0.94); C387(0.88); C15(0.96)  LDD1555  [12]
 LDCM0317  AC54 HEK-293T C304(0.98); C387(0.93); C15(0.96)  LDD1556  [12]
 LDCM0318  AC55 HEK-293T C304(0.92); C387(0.93); C15(1.04)  LDD1557  [12]
 LDCM0319  AC56 HEK-293T C304(1.19); C387(1.03); C15(0.95)  LDD1558  [12]
 LDCM0320  AC57 HEK-293T C304(0.94); C387(0.93); C15(1.17)  LDD1559  [12]
 LDCM0321  AC58 HEK-293T C304(1.00); C387(0.96); C15(0.99)  LDD1560  [12]
 LDCM0322  AC59 HEK-293T C304(0.93); C387(0.99); C15(0.97); C103(0.90)  LDD1561  [12]
 LDCM0323  AC6 HEK-293T C304(1.07); C387(0.98); C15(1.06)  LDD1562  [12]
 LDCM0324  AC60 HEK-293T C304(0.91); C387(0.94); C15(0.98)  LDD1563  [12]
 LDCM0325  AC61 HEK-293T C304(0.90); C387(0.92); C15(1.01)  LDD1564  [12]
 LDCM0326  AC62 HEK-293T C304(0.94); C387(0.94); C15(0.97)  LDD1565  [12]
 LDCM0327  AC63 HEK-293T C304(0.89); C387(0.92); C15(1.11)  LDD1566  [12]
 LDCM0328  AC64 HEK-293T C304(1.06); C387(0.97); C15(0.96)  LDD1567  [12]
 LDCM0334  AC7 HEK-293T C304(1.03); C387(0.90); C15(1.12)  LDD1568  [12]
 LDCM0345  AC8 HEK-293T C304(1.09); C387(1.03); C15(1.04)  LDD1569  [12]
 LDCM0248  AKOS034007472 HEK-293T C304(1.05); C387(0.91); C15(1.00)  LDD1511  [12]
 LDCM0356  AKOS034007680 HEK-293T C304(0.99); C387(0.92); C15(1.17)  LDD1570  [12]
 LDCM0275  AKOS034007705 HEK-293T C304(1.02); C387(1.01); C15(0.91)  LDD1514  [12]
 LDCM0156  Aniline NCI-H1299 12.49  LDD0403  [1]
 LDCM0367  CL1 HEK-293T C304(1.03); C387(0.89); C15(1.03)  LDD1571  [12]
 LDCM0368  CL10 HEK-293T C304(1.10); C387(0.83); C15(1.21)  LDD1572  [12]
 LDCM0369  CL100 HEK-293T C304(0.96); C387(0.96); C15(1.12); C103(1.01)  LDD1573  [12]
 LDCM0370  CL101 HEK-293T C304(1.18); C387(0.97); C15(1.04)  LDD1574  [12]
 LDCM0371  CL102 HEK-293T C304(1.12); C387(0.90); C15(1.09); C103(1.17)  LDD1575  [12]
 LDCM0372  CL103 HEK-293T C304(0.97); C387(0.92); C15(0.96)  LDD1576  [12]
 LDCM0373  CL104 HEK-293T C304(1.02); C387(1.01); C15(0.98); C103(0.98)  LDD1577  [12]
 LDCM0374  CL105 HEK-293T C304(1.11); C387(0.97); C15(1.07)  LDD1578  [12]
 LDCM0375  CL106 HEK-293T C304(1.29); C387(1.00); C15(1.00); C103(0.96)  LDD1579  [12]
 LDCM0376  CL107 HEK-293T C304(1.11); C387(0.96); C15(0.90)  LDD1580  [12]
 LDCM0377  CL108 HEK-293T C304(0.95); C387(1.04); C15(1.00); C103(0.96)  LDD1581  [12]
 LDCM0378  CL109 HEK-293T C304(1.04); C387(1.00); C15(1.09)  LDD1582  [12]
 LDCM0379  CL11 HEK-293T C304(1.09); C387(1.03); C15(0.99)  LDD1583  [12]
 LDCM0380  CL110 HEK-293T C304(1.06); C387(0.92); C15(1.11); C103(1.01)  LDD1584  [12]
 LDCM0381  CL111 HEK-293T C304(0.91); C387(0.92); C15(1.03)  LDD1585  [12]
 LDCM0382  CL112 HEK-293T C304(0.86); C387(1.01); C15(1.22); C103(1.02)  LDD1586  [12]
 LDCM0383  CL113 HEK-293T C304(1.26); C387(1.00); C15(1.03)  LDD1587  [12]
 LDCM0384  CL114 HEK-293T C304(1.11); C387(0.91); C15(1.04); C103(1.09)  LDD1588  [12]
 LDCM0385  CL115 HEK-293T C304(0.99); C387(0.88); C15(0.99)  LDD1589  [12]
 LDCM0386  CL116 HEK-293T C304(1.03); C387(0.98); C15(1.00); C103(1.08)  LDD1590  [12]
 LDCM0387  CL117 HEK-293T C304(1.19); C387(0.97); C15(1.05)  LDD1591  [12]
 LDCM0388  CL118 HEK-293T C304(1.01); C387(1.01); C15(1.00); C103(0.81)  LDD1592  [12]
 LDCM0389  CL119 HEK-293T C304(1.04); C387(0.94); C15(0.93)  LDD1593  [12]
 LDCM0390  CL12 HEK-293T C304(1.08); C387(1.04); C15(0.88)  LDD1594  [12]
 LDCM0391  CL120 HEK-293T C304(1.05); C387(0.94); C15(0.94); C103(1.07)  LDD1595  [12]
 LDCM0392  CL121 HEK-293T C304(1.16); C387(0.91); C15(1.04)  LDD1596  [12]
 LDCM0393  CL122 HEK-293T C304(1.25); C387(0.95); C15(1.03); C103(1.01)  LDD1597  [12]
 LDCM0394  CL123 HEK-293T C304(0.99); C387(0.85); C15(0.93)  LDD1598  [12]
 LDCM0395  CL124 HEK-293T C304(0.92); C387(0.93); C15(1.00); C103(1.10)  LDD1599  [12]
 LDCM0396  CL125 HEK-293T C304(1.01); C387(0.91); C15(1.03)  LDD1600  [12]
 LDCM0397  CL126 HEK-293T C304(1.00); C387(0.92); C15(0.99); C103(1.10)  LDD1601  [12]
 LDCM0398  CL127 HEK-293T C304(0.90); C387(0.90); C15(1.01)  LDD1602  [12]
 LDCM0399  CL128 HEK-293T C304(0.88); C387(1.00); C15(1.01); C103(1.00)  LDD1603  [12]
 LDCM0400  CL13 HEK-293T C304(1.23); C387(0.91); C15(1.12)  LDD1604  [12]
 LDCM0401  CL14 HEK-293T C304(1.18); C387(0.92); C15(1.01); C103(1.03)  LDD1605  [12]
 LDCM0402  CL15 HEK-293T C304(1.18); C387(0.86); C15(0.89)  LDD1606  [12]
 LDCM0403  CL16 HEK-293T C304(0.89); C387(0.95); C15(0.96); C103(1.04)  LDD1607  [12]
 LDCM0404  CL17 HEK-293T C304(1.16); C387(0.82); C15(1.20)  LDD1608  [12]
 LDCM0405  CL18 HEK-293T C304(1.11); C387(0.99); C15(0.94)  LDD1609  [12]
 LDCM0406  CL19 HEK-293T C304(1.19); C387(1.02); C15(0.98); C103(0.93)  LDD1610  [12]
 LDCM0407  CL2 HEK-293T C304(1.03); C387(0.99); C15(1.07); C103(1.09)  LDD1611  [12]
 LDCM0408  CL20 HEK-293T C304(0.88); C387(1.00); C15(0.90)  LDD1612  [12]
 LDCM0409  CL21 HEK-293T C304(1.10); C387(0.92); C15(0.96)  LDD1613  [12]
 LDCM0410  CL22 HEK-293T C304(1.01); C387(1.05); C15(0.95)  LDD1614  [12]
 LDCM0411  CL23 HEK-293T C304(0.94); C387(1.08); C15(1.02)  LDD1615  [12]
 LDCM0412  CL24 HEK-293T C304(1.20); C387(1.14); C15(0.92)  LDD1616  [12]
 LDCM0413  CL25 HEK-293T C304(1.19); C387(0.88); C15(0.96)  LDD1617  [12]
 LDCM0414  CL26 HEK-293T C304(1.21); C387(1.02); C15(0.99); C103(1.17)  LDD1618  [12]
 LDCM0415  CL27 HEK-293T C304(1.14); C387(0.95); C15(0.96)  LDD1619  [12]
 LDCM0416  CL28 HEK-293T C304(0.97); C387(1.01); C15(1.10); C103(1.14)  LDD1620  [12]
 LDCM0417  CL29 HEK-293T C304(1.10); C387(0.98); C15(1.06)  LDD1621  [12]
 LDCM0418  CL3 HEK-293T C304(1.09); C387(0.94); C15(0.90)  LDD1622  [12]
 LDCM0419  CL30 HEK-293T C304(1.02); C387(1.09); C15(0.98)  LDD1623  [12]
 LDCM0420  CL31 HEK-293T C304(1.04); C387(1.13); C15(1.09); C103(0.91)  LDD1624  [12]
 LDCM0421  CL32 HEK-293T C304(0.97); C387(1.07); C15(0.94)  LDD1625  [12]
 LDCM0422  CL33 HEK-293T C304(1.24); C387(0.92); C15(0.99)  LDD1626  [12]
 LDCM0423  CL34 HEK-293T C304(1.01); C387(1.10); C15(0.93)  LDD1627  [12]
 LDCM0424  CL35 HEK-293T C304(1.05); C387(1.18); C15(0.97)  LDD1628  [12]
 LDCM0425  CL36 HEK-293T C304(1.15); C387(1.24); C15(0.88)  LDD1629  [12]
 LDCM0426  CL37 HEK-293T C304(1.06); C387(0.94); C15(0.97)  LDD1630  [12]
 LDCM0428  CL39 HEK-293T C304(1.02); C387(0.99); C15(1.26)  LDD1632  [12]
 LDCM0429  CL4 HEK-293T C304(1.03); C387(0.88); C15(1.00); C103(0.99)  LDD1633  [12]
 LDCM0430  CL40 HEK-293T C304(0.83); C387(1.01); C15(1.00); C103(0.93)  LDD1634  [12]
 LDCM0431  CL41 HEK-293T C304(1.13); C387(0.85); C15(1.14)  LDD1635  [12]
 LDCM0432  CL42 HEK-293T C304(1.04); C387(1.02); C15(0.94)  LDD1636  [12]
 LDCM0433  CL43 HEK-293T C304(1.10); C387(1.10); C15(0.97); C103(0.90)  LDD1637  [12]
 LDCM0434  CL44 HEK-293T C304(0.93); C387(1.06); C15(0.91)  LDD1638  [12]
 LDCM0435  CL45 HEK-293T C304(1.13); C387(1.00); C15(1.18)  LDD1639  [12]
 LDCM0436  CL46 HEK-293T C304(0.99); C387(1.07); C15(0.93)  LDD1640  [12]
 LDCM0437  CL47 HEK-293T C304(1.20); C387(1.19); C15(1.03)  LDD1641  [12]
 LDCM0438  CL48 HEK-293T C304(1.10); C387(1.17); C15(0.88)  LDD1642  [12]
 LDCM0439  CL49 HEK-293T C304(1.05); C387(0.96); C15(0.99)  LDD1643  [12]
 LDCM0440  CL5 HEK-293T C304(1.27); C387(0.91); C15(1.13)  LDD1644  [12]
 LDCM0441  CL50 HEK-293T C304(1.11); C387(1.02); C15(1.03); C103(1.04)  LDD1645  [12]
 LDCM0443  CL52 HEK-293T C304(1.08); C387(1.03); C15(1.01); C103(1.03)  LDD1646  [12]
 LDCM0444  CL53 HEK-293T C304(1.05); C387(0.85); C15(1.14)  LDD1647  [12]
 LDCM0445  CL54 HEK-293T C304(1.13); C387(0.88); C15(0.94)  LDD1648  [12]
 LDCM0446  CL55 HEK-293T C304(1.07); C387(1.08); C15(0.92); C103(0.98)  LDD1649  [12]
 LDCM0447  CL56 HEK-293T C304(1.00); C387(1.00); C15(0.93)  LDD1650  [12]
 LDCM0448  CL57 HEK-293T C304(1.14); C387(0.90); C15(1.02)  LDD1651  [12]
 LDCM0449  CL58 HEK-293T C304(1.16); C387(1.03); C15(0.84)  LDD1652  [12]
 LDCM0450  CL59 HEK-293T C304(1.09); C387(1.13); C15(0.96)  LDD1653  [12]
 LDCM0451  CL6 HEK-293T C304(1.07); C387(0.86); C15(1.05)  LDD1654  [12]
 LDCM0452  CL60 HEK-293T C304(1.01); C387(1.11); C15(0.93)  LDD1655  [12]
 LDCM0453  CL61 HEK-293T C304(1.13); C387(0.98); C15(0.98)  LDD1656  [12]
 LDCM0454  CL62 HEK-293T C304(1.10); C387(1.03); C15(1.03); C103(1.14)  LDD1657  [12]
 LDCM0455  CL63 HEK-293T C304(1.01); C387(1.04); C15(1.00)  LDD1658  [12]
 LDCM0456  CL64 HEK-293T C304(0.96); C387(0.90); C15(0.98); C103(0.99)  LDD1659  [12]
 LDCM0457  CL65 HEK-293T C304(0.98); C387(0.95); C15(1.14)  LDD1660  [12]
 LDCM0458  CL66 HEK-293T C304(1.02); C387(0.95); C15(1.00)  LDD1661  [12]
 LDCM0459  CL67 HEK-293T C304(1.01); C387(1.07); C15(0.91); C103(0.88)  LDD1662  [12]
 LDCM0460  CL68 HEK-293T C304(0.98); C387(0.97); C15(0.91)  LDD1663  [12]
 LDCM0461  CL69 HEK-293T C304(1.08); C387(0.98); C15(0.93)  LDD1664  [12]
 LDCM0462  CL7 HEK-293T C304(1.09); C387(1.00); C15(0.96); C103(0.90)  LDD1665  [12]
 LDCM0463  CL70 HEK-293T C304(1.22); C387(1.06); C15(0.89)  LDD1666  [12]
 LDCM0464  CL71 HEK-293T C304(1.06); C387(1.02); C15(0.99)  LDD1667  [12]
 LDCM0465  CL72 HEK-293T C304(1.24); C387(1.08); C15(0.87)  LDD1668  [12]
 LDCM0466  CL73 HEK-293T C304(1.26); C387(0.91); C15(1.00)  LDD1669  [12]
 LDCM0467  CL74 HEK-293T C304(1.13); C387(0.96); C15(1.04); C103(1.08)  LDD1670  [12]
 LDCM0469  CL76 HEK-293T C304(1.04); C387(1.01); C15(1.04); C103(1.09)  LDD1672  [12]
 LDCM0470  CL77 HEK-293T C304(1.03); C387(0.83); C15(1.17)  LDD1673  [12]
 LDCM0471  CL78 HEK-293T C304(1.07); C387(1.01); C15(0.99)  LDD1674  [12]
 LDCM0472  CL79 HEK-293T C304(1.16); C387(1.04); C15(0.94); C103(1.01)  LDD1675  [12]
 LDCM0473  CL8 HEK-293T C304(0.80); C387(0.69); C15(1.02)  LDD1676  [12]
 LDCM0474  CL80 HEK-293T C304(1.16); C387(1.06); C15(0.86)  LDD1677  [12]
 LDCM0475  CL81 HEK-293T C304(1.04); C387(1.08); C15(0.96)  LDD1678  [12]
 LDCM0476  CL82 HEK-293T C304(1.02); C387(1.03); C15(0.91)  LDD1679  [12]
 LDCM0477  CL83 HEK-293T C304(0.99); C387(0.98); C15(0.96)  LDD1680  [12]
 LDCM0478  CL84 HEK-293T C304(1.09); C387(0.99); C15(0.90)  LDD1681  [12]
 LDCM0479  CL85 HEK-293T C304(0.91); C387(0.94); C15(1.00)  LDD1682  [12]
 LDCM0480  CL86 HEK-293T C304(1.05); C387(0.95); C15(1.07); C103(1.10)  LDD1683  [12]
 LDCM0481  CL87 HEK-293T C304(0.94); C387(0.92); C15(1.02)  LDD1684  [12]
 LDCM0482  CL88 HEK-293T C304(0.95); C387(0.92); C15(1.04); C103(1.16)  LDD1685  [12]
 LDCM0483  CL89 HEK-293T C304(1.16); C387(0.89); C15(1.12)  LDD1686  [12]
 LDCM0484  CL9 HEK-293T C304(1.03); C387(1.00); C15(0.98)  LDD1687  [12]
 LDCM0485  CL90 HEK-293T C304(1.13); C387(0.74); C15(1.08)  LDD1688  [12]
 LDCM0486  CL91 HEK-293T C304(1.10); C387(1.06); C15(1.00); C103(0.91)  LDD1689  [12]
 LDCM0487  CL92 HEK-293T C304(0.98); C387(0.90); C15(0.94)  LDD1690  [12]
 LDCM0488  CL93 HEK-293T C304(1.08); C387(0.91); C15(0.95)  LDD1691  [12]
 LDCM0489  CL94 HEK-293T C304(1.00); C387(0.94); C15(0.96)  LDD1692  [12]
 LDCM0490  CL95 HEK-293T C304(0.98); C387(0.82); C15(1.10)  LDD1693  [12]
 LDCM0491  CL96 HEK-293T C304(1.39); C387(0.93); C15(0.97)  LDD1694  [12]
 LDCM0492  CL97 HEK-293T C304(1.03); C387(0.95); C15(1.02)  LDD1695  [12]
 LDCM0493  CL98 HEK-293T C304(1.17); C387(0.95); C15(1.03); C103(0.99)  LDD1696  [12]
 LDCM0494  CL99 HEK-293T C304(0.91); C387(0.96); C15(1.12)  LDD1697  [12]
 LDCM0495  E2913 HEK-293T C304(1.04); C387(0.95); C15(1.01)  LDD1698  [12]
 LDCM0468  Fragment33 HEK-293T C304(1.13); C387(0.93); C15(0.96)  LDD1671  [12]
 LDCM0427  Fragment51 HEK-293T C304(0.95); C387(1.00); C15(1.02); C103(0.95)  LDD1631  [12]
 LDCM0022  KB02 HEK-293T C304(0.93); C387(0.93); C15(1.01)  LDD1492  [12]
 LDCM0023  KB03 HEK-293T C304(0.92); C387(0.96); C15(0.99)  LDD1497  [12]
 LDCM0024  KB05 COLO792 C304(3.28)  LDD3310  [3]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
E3 ubiquitin-protein ligase TRIM23 (TRIM23) Arf family P36406
Other
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Zinc finger protein 830 (ZNF830) . Q96NB3

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 An Azo Coupling-Based Chemoproteomic Approach to Systematically Profile the Tyrosine Reactivity in the Human Proteome. Anal Chem. 2021 Jul 27;93(29):10334-10342. doi: 10.1021/acs.analchem.1c01935. Epub 2021 Jul 12.
3 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
4 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
5 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
6 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
7 DFT-Guided Discovery of Ethynyl-Triazolyl-Phosphinates as Modular Electrophiles for Chemoselective Cysteine Bioconjugation and Profiling. Angew Chem Int Ed Engl. 2022 Oct 10;61(41):e202205348. doi: 10.1002/anie.202205348. Epub 2022 Aug 22.
Mass spectrometry data entry: PXD033004
8 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
9 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
10 Global profiling identifies a stress-responsive tyrosine site on EDC3 regulating biomolecular condensate formation. Cell Chem Biol. 2022 Dec 15;29(12):1709-1720.e7. doi: 10.1016/j.chembiol.2022.11.008. Epub 2022 Dec 6.
Mass spectrometry data entry: PXD038010
11 Ligand and Target Discovery by Fragment-Based Screening in Human Cells. Cell. 2017 Jan 26;168(3):527-541.e29. doi: 10.1016/j.cell.2016.12.029. Epub 2017 Jan 19.
12 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402