Details of the Target

General Information of Target

Target ID LDTP05796
Target Name Mitogen-activated protein kinase kinase kinase 1 (MAP3K1)
Gene Name MAP3K1
Gene ID 4214
Synonyms
MAPKKK1; MEKK; MEKK1; Mitogen-activated protein kinase kinase kinase 1; EC 2.7.11.25; MAPK/ERK kinase kinase 1; MEK kinase 1; MEKK 1; EC 2.3.2.27
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MAAAAGNRASSSGFPGARATSPEAGGGGGALKASSAPAAAAGLLREAGSGGRERADWRRR
QLRKVRSVELDQLPEQPLFLAASPPASSTSPSPEPADAAGSGTGFQPVAVPPPHGAASRG
GAHLTESVAAPDSGASSPAAAEPGEKRAPAAEPSPAAAPAGREMENKETLKGLHKMDDRP
EERMIREKLKATCMPAWKHEWLERRNRRGPVVVKPIPVKGDGSEMNHLAAESPGEVQASA
ASPASKGRRSPSPGNSPSGRTVKSESPGVRRKRVSPVPFQSGRITPPRRAPSPDGFSPYS
PEETNRRVNKVMRARLYLLQQIGPNSFLIGGDSPDNKYRVFIGPQNCSCARGTFCIHLLF
VMLRVFQLEPSDPMLWRKTLKNFEVESLFQKYHSRRSSRIKAPSRNTIQKFVSRMSNSHT
LSSSSTSTSSSENSIKDEEEQMCPICLLGMLDEESLTVCEDGCRNKLHHHCMSIWAEECR
RNREPLICPLCRSKWRSHDFYSHELSSPVDSPSSLRAAQQQTVQQQPLAGSRRNQESNFN
LTHYGTQQIPPAYKDLAEPWIQVFGMELVGCLFSRNWNVREMALRRLSHDVSGALLLANG
ESTGNSGGSSGSSPSGGATSGSSQTSISGDVVEACCSVLSMVCADPVYKVYVAALKTLRA
MLVYTPCHSLAERIKLQRLLQPVVDTILVKCADANSRTSQLSISTLLELCKGQAGELAVG
REILKAGSIGIGGVDYVLNCILGNQTESNNWQELLGRLCLIDRLLLEFPAEFYPHIVSTD
VSQAEPVEIRYKKLLSLLTFALQSIDNSHSMVGKLSRRIYLSSARMVTTVPHVFSKLLEM
LSVSSSTHFTRMRRRLMAIADEVEIAEAIQLGVEDTLDGQQDSFLQASVPNNYLETTENS
SPECTVHLEKTGKGLCATKLSASSEDISERLASISVGPSSSTTTTTTTTEQPKPMVQTKG
RPHSQCLNSSPLSHHSQLMFPALSTPSSSTPSVPAGTATDVSKHRLQGFIPCRIPSASPQ
TQRKFSLQFHRNCPENKDSDKLSPVFTQSRPLPSSNIHRPKPSRPTPGNTSKQGDPSKNS
MTLDLNSSSKCDDSFGCSSNSSNAVIPSDETVFTPVEEKCRLDVNTELNSSIEDLLEASM
PSSDTTVTFKSEVAVLSPEKAENDDTYKDDVNHNQKCKEKMEAEEEEALAIAMAMSASQD
ALPIVPQLQVENGEDIIIIQQDTPETLPGHTKAKQPYREDTEWLKGQQIGLGAFSSCYQA
QDVGTGTLMAVKQVTYVRNTSSEQEEVVEALREEIRMMSHLNHPNIIRMLGATCEKSNYN
LFIEWMAGGSVAHLLSKYGAFKESVVINYTEQLLRGLSYLHENQIIHRDVKGANLLIDST
GQRLRIADFGAAARLASKGTGAGEFQGQLLGTIAFMAPEVLRGQQYGRSCDVWSVGCAII
EMACAKPPWNAEKHSNHLALIFKIASATTAPSIPSHLSPGLRDVALRCLELQPQDRPPSR
ELLKHPVFRTTW
Target Type
Clinical trial
Target Bioclass
Enzyme
Family
Protein kinase superfamily, STE Ser/Thr protein kinase family, MAP kinase kinase kinase subfamily
Function
Component of a protein kinase signal transduction cascade. Activates the ERK and JNK kinase pathways by phosphorylation of MAP2K1 and MAP2K4. May phosphorylate the MAPK8/JNK1 kinase. Activates CHUK and IKBKB, the central protein kinases of the NF-kappa-B pathway.
TTD ID
T06031
Uniprot ID
Q13233
DrugMap ID
TTQBCEJ
Ensemble ID
ENST00000399503.4
HGNC ID
HGNC:6848
ChEMBL ID
CHEMBL3956

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 3 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C1012(1.50); C1091(3.45); C1097(3.45)  LDD0080  [1]
ATP probe
 Probe Info  		N.A.  LDD0199  [2]
IPM
 Probe Info  		N.A.  LDD0147  [3]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HCT 116 C1012(0.93)  LDD0531  [1]
 LDCM0215  AC10 HCT 116 C1012(0.79)  LDD0532  [1]
 LDCM0216  AC100 HEK-293T C347(1.02); C349(0.80)  LDD0814  [1]
 LDCM0217  AC101 HEK-293T C347(1.13); C349(1.04)  LDD0815  [1]
 LDCM0218  AC102 HEK-293T C347(1.17); C349(0.87)  LDD0816  [1]
 LDCM0219  AC103 HEK-293T C347(1.06); C349(0.92)  LDD0817  [1]
 LDCM0220  AC104 HEK-293T C347(1.26); C349(0.97)  LDD0818  [1]
 LDCM0221  AC105 HEK-293T C347(1.00); C349(0.82)  LDD0819  [1]
 LDCM0222  AC106 HEK-293T C347(1.29); C349(1.05)  LDD0820  [1]
 LDCM0223  AC107 HEK-293T C347(1.07); C349(0.80)  LDD0821  [1]
 LDCM0224  AC108 HEK-293T C347(1.02); C349(0.92)  LDD0822  [1]
 LDCM0225  AC109 HEK-293T C347(1.10); C349(0.94)  LDD0823  [1]
 LDCM0226  AC11 HCT 116 C1012(0.90)  LDD0543  [1]
 LDCM0227  AC110 HEK-293T C347(1.13); C349(0.86)  LDD0825  [1]
 LDCM0228  AC111 HEK-293T C347(1.05); C349(0.71)  LDD0826  [1]
 LDCM0229  AC112 HEK-293T C347(1.24); C349(0.85)  LDD0827  [1]
 LDCM0230  AC113 HCT 116 C1012(0.91)  LDD0547  [1]
 LDCM0231  AC114 HCT 116 C1012(1.01)  LDD0548  [1]
 LDCM0232  AC115 HCT 116 C1012(0.78)  LDD0549  [1]
 LDCM0233  AC116 HCT 116 C1012(0.96)  LDD0550  [1]
 LDCM0234  AC117 HCT 116 C1012(0.94)  LDD0551  [1]
 LDCM0235  AC118 HCT 116 C1012(1.11)  LDD0552  [1]
 LDCM0236  AC119 HCT 116 C1012(2.14)  LDD0553  [1]
 LDCM0237  AC12 HCT 116 C1012(0.73)  LDD0554  [1]
 LDCM0238  AC120 HCT 116 C1012(1.38)  LDD0555  [1]
 LDCM0239  AC121 HCT 116 C1012(1.23)  LDD0556  [1]
 LDCM0240  AC122 HCT 116 C1012(1.32)  LDD0557  [1]
 LDCM0241  AC123 HCT 116 C1012(1.21)  LDD0558  [1]
 LDCM0242  AC124 HCT 116 C1012(1.18)  LDD0559  [1]
 LDCM0243  AC125 HCT 116 C1012(1.14)  LDD0560  [1]
 LDCM0244  AC126 HCT 116 C1012(1.28)  LDD0561  [1]
 LDCM0245  AC127 HCT 116 C1012(1.08)  LDD0562  [1]
 LDCM0246  AC128 HCT 116 C1012(0.78)  LDD0563  [1]
 LDCM0247  AC129 HCT 116 C1012(0.94)  LDD0564  [1]
 LDCM0249  AC130 HCT 116 C1012(1.10)  LDD0566  [1]
 LDCM0250  AC131 HCT 116 C1012(0.93)  LDD0567  [1]
 LDCM0251  AC132 HCT 116 C1012(1.00)  LDD0568  [1]
 LDCM0252  AC133 HCT 116 C1012(1.04)  LDD0569  [1]
 LDCM0253  AC134 HCT 116 C1012(0.94)  LDD0570  [1]
 LDCM0254  AC135 HCT 116 C1012(1.06)  LDD0571  [1]
 LDCM0255  AC136 HCT 116 C1012(0.86)  LDD0572  [1]
 LDCM0256  AC137 HCT 116 C1012(0.93)  LDD0573  [1]
 LDCM0257  AC138 HCT 116 C1012(0.94)  LDD0574  [1]
 LDCM0258  AC139 HCT 116 C1012(0.96)  LDD0575  [1]
 LDCM0259  AC14 HCT 116 C1012(0.70)  LDD0576  [1]
 LDCM0260  AC140 HCT 116 C1012(1.07)  LDD0577  [1]
 LDCM0261  AC141 HCT 116 C1012(1.09)  LDD0578  [1]
 LDCM0262  AC142 HCT 116 C1012(0.92)  LDD0579  [1]
 LDCM0270  AC15 HCT 116 C1012(0.75)  LDD0587  [1]
 LDCM0276  AC17 HCT 116 C1012(0.83)  LDD0593  [1]
 LDCM0277  AC18 HCT 116 C1012(0.93)  LDD0594  [1]
 LDCM0278  AC19 HCT 116 C1012(0.80)  LDD0595  [1]
 LDCM0279  AC2 HCT 116 C1012(1.05)  LDD0596  [1]
 LDCM0280  AC20 HCT 116 C1012(1.10)  LDD0597  [1]
 LDCM0281  AC21 HCT 116 C1012(0.98)  LDD0598  [1]
 LDCM0282  AC22 HCT 116 C1012(0.85)  LDD0599  [1]
 LDCM0283  AC23 HCT 116 C1012(0.83)  LDD0600  [1]
 LDCM0284  AC24 HCT 116 C1012(0.82)  LDD0601  [1]
 LDCM0285  AC25 HEK-293T C347(0.94); C349(0.94)  LDD0883  [1]
 LDCM0286  AC26 HEK-293T C347(1.05); C349(1.05)  LDD0884  [1]
 LDCM0287  AC27 HEK-293T C347(0.89); C349(0.89)  LDD0885  [1]
 LDCM0288  AC28 HEK-293T C347(0.86); C349(0.86)  LDD0886  [1]
 LDCM0289  AC29 HEK-293T C347(1.13); C349(1.13)  LDD0887  [1]
 LDCM0290  AC3 HCT 116 C1012(0.85)  LDD0607  [1]
 LDCM0291  AC30 HEK-293T C347(1.02); C349(1.02)  LDD0889  [1]
 LDCM0292  AC31 HEK-293T C347(1.02); C349(1.02)  LDD0890  [1]
 LDCM0293  AC32 HEK-293T C347(0.89); C349(0.89)  LDD0891  [1]
 LDCM0294  AC33 HEK-293T C347(0.99); C349(0.99)  LDD0892  [1]
 LDCM0295  AC34 HEK-293T C347(0.98); C349(0.98)  LDD0893  [1]
 LDCM0296  AC35 HEK-293T C1314(1.02); C193(0.93)  LDD1535  [4]
 LDCM0297  AC36 HEK-293T C193(1.01)  LDD1536  [4]
 LDCM0298  AC37 HEK-293T C710(1.14); C691(1.03); C1012(0.85)  LDD1537  [4]
 LDCM0299  AC38 HEK-293T C1314(1.10); C691(1.05); C1012(1.13)  LDD1538  [4]
 LDCM0300  AC39 HEK-293T C193(1.02); C1012(1.13)  LDD1539  [4]
 LDCM0301  AC4 HCT 116 C1012(0.82)  LDD0618  [1]
 LDCM0302  AC40 HEK-293T C691(1.08)  LDD1541  [4]
 LDCM0303  AC41 HEK-293T C710(0.87); C1314(1.10); C193(1.11)  LDD1542  [4]
 LDCM0304  AC42 HEK-293T C1314(1.09); C691(1.07)  LDD1543  [4]
 LDCM0305  AC43 HEK-293T C1314(1.18); C193(0.93)  LDD1544  [4]
 LDCM0306  AC44 HEK-293T C193(1.10)  LDD1545  [4]
 LDCM0307  AC45 HEK-293T C710(0.82); C691(1.17); C1012(0.92)  LDD1546  [4]
 LDCM0308  AC46 HEK-293T C1314(1.07); C691(1.12); C1012(1.04)  LDD1547  [4]
 LDCM0309  AC47 HEK-293T C193(0.97); C1012(1.07)  LDD1548  [4]
 LDCM0310  AC48 HEK-293T C691(1.13)  LDD1549  [4]
 LDCM0311  AC49 HEK-293T C710(0.94); C1314(1.12); C193(1.01)  LDD1550  [4]
 LDCM0312  AC5 HCT 116 C1012(0.78)  LDD0629  [1]
 LDCM0313  AC50 HEK-293T C1314(1.03); C691(1.02)  LDD1552  [4]
 LDCM0314  AC51 HEK-293T C1314(1.01); C193(0.97)  LDD1553  [4]
 LDCM0315  AC52 HEK-293T C193(1.04)  LDD1554  [4]
 LDCM0316  AC53 HEK-293T C710(0.84); C691(1.16); C1012(0.96)  LDD1555  [4]
 LDCM0317  AC54 HEK-293T C1314(1.12); C691(1.17); C1012(1.14)  LDD1556  [4]
 LDCM0318  AC55 HEK-293T C193(0.98); C1012(1.11)  LDD1557  [4]
 LDCM0319  AC56 HEK-293T C691(1.08)  LDD1558  [4]
 LDCM0320  AC57 HEK-293T C1012(0.96); C347(0.90); C349(0.90)  LDD0918  [1]
 LDCM0321  AC58 HEK-293T C1012(1.19); C347(1.04); C349(1.04)  LDD0919  [1]
 LDCM0322  AC59 HEK-293T C1012(1.62); C347(1.13); C349(1.13)  LDD0920  [1]
 LDCM0323  AC6 HCT 116 C1012(0.91)  LDD0640  [1]
 LDCM0324  AC60 HEK-293T C1012(1.36); C347(1.01); C349(1.01)  LDD0922  [1]
 LDCM0325  AC61 HEK-293T C1012(1.10); C347(1.00); C349(1.00)  LDD0923  [1]
 LDCM0326  AC62 HEK-293T C1012(1.32); C347(1.05); C349(1.05)  LDD0924  [1]
 LDCM0327  AC63 HEK-293T C1012(1.11); C347(1.05); C349(1.05)  LDD0925  [1]
 LDCM0328  AC64 HEK-293T C1012(1.00); C347(1.26); C349(1.26)  LDD0926  [1]
 LDCM0329  AC65 HEK-293T C1012(1.27); C347(1.09); C349(1.09)  LDD0927  [1]
 LDCM0330  AC66 HEK-293T C1012(1.14); C347(1.06); C349(1.06)  LDD0928  [1]
 LDCM0331  AC67 HEK-293T C1012(0.94); C347(1.26); C349(1.26)  LDD0929  [1]
 LDCM0332  AC68 HEK-293T C347(1.01); C349(1.01)  LDD0930  [1]
 LDCM0333  AC69 HEK-293T C347(1.01); C349(1.01)  LDD0931  [1]
 LDCM0334  AC7 HCT 116 C1012(0.68)  LDD0651  [1]
 LDCM0335  AC70 HEK-293T C347(0.98); C349(0.98)  LDD0933  [1]
 LDCM0336  AC71 HEK-293T C347(0.95); C349(0.95)  LDD0934  [1]
 LDCM0337  AC72 HEK-293T C347(0.98); C349(0.98)  LDD0935  [1]
 LDCM0338  AC73 HEK-293T C347(0.74); C349(0.74)  LDD0936  [1]
 LDCM0339  AC74 HEK-293T C347(0.88); C349(0.88)  LDD0937  [1]
 LDCM0340  AC75 HEK-293T C347(0.77); C349(0.77)  LDD0938  [1]
 LDCM0341  AC76 HEK-293T C347(0.95); C349(0.95)  LDD0939  [1]
 LDCM0342  AC77 HEK-293T C347(1.18); C349(1.18)  LDD0940  [1]
 LDCM0343  AC78 HEK-293T C347(1.00); C349(1.00)  LDD0941  [1]
 LDCM0344  AC79 HEK-293T C347(1.08); C349(1.08)  LDD0942  [1]
 LDCM0345  AC8 HCT 116 C1012(0.71)  LDD0662  [1]
 LDCM0346  AC80 HEK-293T C347(0.95); C349(0.95)  LDD0944  [1]
 LDCM0347  AC81 HEK-293T C347(1.01); C349(1.01)  LDD0945  [1]
 LDCM0348  AC82 HEK-293T C347(1.13); C349(1.13)  LDD0946  [1]
 LDCM0349  AC83 HCT 116 C1012(1.18)  LDD0666  [1]
 LDCM0350  AC84 HCT 116 C1012(1.05)  LDD0667  [1]
 LDCM0351  AC85 HCT 116 C1012(1.09)  LDD0668  [1]
 LDCM0352  AC86 HCT 116 C1012(1.08)  LDD0669  [1]
 LDCM0353  AC87 HCT 116 C1012(1.11)  LDD0670  [1]
 LDCM0354  AC88 HCT 116 C1012(1.30)  LDD0671  [1]
 LDCM0355  AC89 HCT 116 C1012(1.10)  LDD0672  [1]
 LDCM0357  AC90 HCT 116 C1012(1.20)  LDD0674  [1]
 LDCM0358  AC91 HCT 116 C1012(1.11)  LDD0675  [1]
 LDCM0359  AC92 HCT 116 C1012(1.00)  LDD0676  [1]
 LDCM0360  AC93 HCT 116 C1012(1.09)  LDD0677  [1]
 LDCM0361  AC94 HCT 116 C1012(0.81)  LDD0678  [1]
 LDCM0362  AC95 HCT 116 C1012(1.10)  LDD0679  [1]
 LDCM0363  AC96 HCT 116 C1012(0.75)  LDD0680  [1]
 LDCM0364  AC97 HCT 116 C1012(1.10)  LDD0681  [1]
 LDCM0365  AC98 HEK-293T C347(1.25); C349(1.05)  LDD0963  [1]
 LDCM0366  AC99 HEK-293T C347(0.99); C349(1.01)  LDD0964  [1]
 LDCM0248  AKOS034007472 HCT 116 C1012(0.83)  LDD0565  [1]
 LDCM0356  AKOS034007680 HCT 116 C1012(0.80)  LDD0673  [1]
 LDCM0275  AKOS034007705 HCT 116 C1012(0.72)  LDD0592  [1]
 LDCM0367  CL1 HCT 116 C1012(1.24)  LDD0684  [1]
 LDCM0368  CL10 HCT 116 C1012(1.19)  LDD0685  [1]
 LDCM0369  CL100 HCT 116 C1012(1.09)  LDD0686  [1]
 LDCM0370  CL101 HCT 116 C1012(0.73)  LDD0687  [1]
 LDCM0371  CL102 HCT 116 C1012(0.81)  LDD0688  [1]
 LDCM0372  CL103 HCT 116 C1012(0.74)  LDD0689  [1]
 LDCM0373  CL104 HCT 116 C1012(0.69)  LDD0690  [1]
 LDCM0374  CL105 HCT 116 C1012(0.81)  LDD0691  [1]
 LDCM0375  CL106 HCT 116 C1012(0.75)  LDD0692  [1]
 LDCM0376  CL107 HCT 116 C1012(0.87)  LDD0693  [1]
 LDCM0377  CL108 HCT 116 C1012(0.76)  LDD0694  [1]
 LDCM0378  CL109 HCT 116 C1012(1.01)  LDD0695  [1]
 LDCM0379  CL11 HCT 116 C1012(1.48)  LDD0696  [1]
 LDCM0380  CL110 HCT 116 C1012(0.72)  LDD0697  [1]
 LDCM0381  CL111 HCT 116 C1012(0.76)  LDD0698  [1]
 LDCM0382  CL112 HEK-293T C347(0.85); C349(0.85)  LDD0980  [1]
 LDCM0383  CL113 HEK-293T C347(1.06); C349(1.06)  LDD0981  [1]
 LDCM0384  CL114 HEK-293T C347(1.00); C349(1.00)  LDD0982  [1]
 LDCM0385  CL115 HEK-293T C347(0.97); C349(0.97)  LDD0983  [1]
 LDCM0386  CL116 HEK-293T C347(1.02); C349(1.02)  LDD0984  [1]
 LDCM0387  CL117 HEK-293T C710(1.01)  LDD1591  [4]
 LDCM0388  CL118 HEK-293T C1314(1.07)  LDD1592  [4]
 LDCM0389  CL119 HEK-293T C193(1.14)  LDD1593  [4]
 LDCM0390  CL12 HCT 116 C1012(1.26)  LDD0707  [1]
 LDCM0391  CL120 HEK-293T C1314(1.20); C193(1.06)  LDD1595  [4]
 LDCM0392  CL121 HEK-293T C710(0.92)  LDD1596  [4]
 LDCM0393  CL122 HEK-293T C1314(0.95)  LDD1597  [4]
 LDCM0394  CL123 HEK-293T C193(1.04)  LDD1598  [4]
 LDCM0395  CL124 HEK-293T C1314(0.99); C193(0.86)  LDD1599  [4]
 LDCM0396  CL125 HEK-293T C1012(0.82); C347(1.08); C349(1.08)  LDD0994  [1]
 LDCM0397  CL126 HEK-293T C1012(1.25); C347(0.98); C349(0.98)  LDD0995  [1]
 LDCM0398  CL127 HEK-293T C1012(1.02); C347(0.86); C349(0.86)  LDD0996  [1]
 LDCM0399  CL128 HEK-293T C1012(1.32); C347(1.03); C349(1.03)  LDD0997  [1]
 LDCM0400  CL13 HCT 116 C1012(0.94)  LDD0717  [1]
 LDCM0401  CL14 HCT 116 C1012(0.91)  LDD0718  [1]
 LDCM0402  CL15 HCT 116 C1012(0.82)  LDD0719  [1]
 LDCM0403  CL16 HCT 116 C1012(1.12)  LDD0720  [1]
 LDCM0404  CL17 HCT 116 C1012(0.83)  LDD0721  [1]
 LDCM0405  CL18 HCT 116 C1012(0.97)  LDD0722  [1]
 LDCM0406  CL19 HCT 116 C1012(0.69)  LDD0723  [1]
 LDCM0407  CL2 HCT 116 C1012(0.94)  LDD0724  [1]
 LDCM0408  CL20 HCT 116 C1012(0.83)  LDD0725  [1]
 LDCM0409  CL21 HCT 116 C1012(0.87)  LDD0726  [1]
 LDCM0410  CL22 HCT 116 C1012(0.79)  LDD0727  [1]
 LDCM0411  CL23 HCT 116 C1012(0.97)  LDD0728  [1]
 LDCM0412  CL24 HCT 116 C1012(1.06)  LDD0729  [1]
 LDCM0413  CL25 HCT 116 C1012(1.20)  LDD0730  [1]
 LDCM0414  CL26 HCT 116 C1012(0.90)  LDD0731  [1]
 LDCM0415  CL27 HCT 116 C1012(0.96)  LDD0732  [1]
 LDCM0416  CL28 HCT 116 C1012(0.96)  LDD0733  [1]
 LDCM0417  CL29 HCT 116 C1012(1.08)  LDD0734  [1]
 LDCM0418  CL3 HCT 116 C1012(0.99)  LDD0735  [1]
 LDCM0419  CL30 HCT 116 C1012(1.02)  LDD0736  [1]
 LDCM0420  CL31 HEK-293T C1314(1.09); C193(0.95)  LDD1624  [4]
 LDCM0421  CL32 HEK-293T C193(0.93)  LDD1625  [4]
 LDCM0422  CL33 HEK-293T C710(0.90); C691(1.27); C1012(1.00)  LDD1626  [4]
 LDCM0423  CL34 HEK-293T C1314(1.19); C691(1.09); C1012(1.12)  LDD1627  [4]
 LDCM0424  CL35 HEK-293T C193(0.80); C1012(1.00)  LDD1628  [4]
 LDCM0425  CL36 HEK-293T C691(1.12)  LDD1629  [4]
 LDCM0426  CL37 HEK-293T C710(0.95)  LDD1630  [4]
 LDCM0428  CL39 HEK-293T C193(1.02)  LDD1632  [4]
 LDCM0429  CL4 HCT 116 C1012(0.97)  LDD0746  [1]
 LDCM0430  CL40 HEK-293T C1314(1.04); C193(1.15)  LDD1634  [4]
 LDCM0431  CL41 HEK-293T C710(0.92); C1314(1.06); C193(1.03)  LDD1635  [4]
 LDCM0432  CL42 HEK-293T C1314(1.00); C691(0.99)  LDD1636  [4]
 LDCM0433  CL43 HEK-293T C1314(1.00); C193(0.85)  LDD1637  [4]
 LDCM0434  CL44 HEK-293T C193(0.90)  LDD1638  [4]
 LDCM0435  CL45 HEK-293T C710(0.85); C691(1.25); C1012(0.84)  LDD1639  [4]
 LDCM0436  CL46 HEK-293T C1314(1.11); C691(1.13); C1012(1.16)  LDD1640  [4]
 LDCM0437  CL47 HEK-293T C193(0.92); C1012(1.18)  LDD1641  [4]
 LDCM0438  CL48 HEK-293T C691(1.13)  LDD1642  [4]
 LDCM0439  CL49 HEK-293T C710(0.98)  LDD1643  [4]
 LDCM0440  CL5 HCT 116 C1012(0.87)  LDD0757  [1]
 LDCM0441  CL50 HEK-293T C1314(1.06)  LDD1645  [4]
 LDCM0443  CL52 HEK-293T C1314(1.12); C193(1.01)  LDD1646  [4]
 LDCM0444  CL53 HEK-293T C710(0.43); C1314(1.28); C193(1.03)  LDD1647  [4]
 LDCM0445  CL54 HEK-293T C1314(1.21); C691(1.24)  LDD1648  [4]
 LDCM0446  CL55 HEK-293T C1314(1.21); C193(0.99)  LDD1649  [4]
 LDCM0447  CL56 HEK-293T C193(0.97)  LDD1650  [4]
 LDCM0448  CL57 HEK-293T C710(0.88); C691(1.23); C1012(1.00)  LDD1651  [4]
 LDCM0449  CL58 HEK-293T C1314(1.26); C691(1.23); C1012(1.55)  LDD1652  [4]
 LDCM0450  CL59 HEK-293T C193(0.90); C1012(1.08)  LDD1653  [4]
 LDCM0451  CL6 HCT 116 C1012(0.95)  LDD0768  [1]
 LDCM0452  CL60 HEK-293T C691(1.07)  LDD1655  [4]
 LDCM0453  CL61 HEK-293T C710(1.00)  LDD1656  [4]
 LDCM0454  CL62 HEK-293T C1314(1.15)  LDD1657  [4]
 LDCM0455  CL63 HEK-293T C193(1.09)  LDD1658  [4]
 LDCM0456  CL64 HEK-293T C1314(1.19); C193(0.95)  LDD1659  [4]
 LDCM0457  CL65 HEK-293T C710(0.94); C1314(1.19); C193(1.10)  LDD1660  [4]
 LDCM0458  CL66 HEK-293T C1314(1.11); C691(1.00)  LDD1661  [4]
 LDCM0459  CL67 HEK-293T C1314(1.13); C193(0.91)  LDD1662  [4]
 LDCM0460  CL68 HEK-293T C193(1.01)  LDD1663  [4]
 LDCM0461  CL69 HEK-293T C710(0.95); C691(1.22); C1012(0.90)  LDD1664  [4]
 LDCM0462  CL7 HCT 116 C1012(0.87)  LDD0779  [1]
 LDCM0463  CL70 HEK-293T C1314(1.20); C691(1.17); C1012(1.07)  LDD1666  [4]
 LDCM0464  CL71 HEK-293T C193(0.93); C1012(1.02)  LDD1667  [4]
 LDCM0465  CL72 HEK-293T C691(1.10)  LDD1668  [4]
 LDCM0466  CL73 HEK-293T C710(0.98)  LDD1669  [4]
 LDCM0467  CL74 HEK-293T C1314(1.08)  LDD1670  [4]
 LDCM0469  CL76 HEK-293T C1314(1.02); C193(1.00)  LDD1672  [4]
 LDCM0470  CL77 HEK-293T C710(1.03); C1314(1.25); C193(1.06)  LDD1673  [4]
 LDCM0471  CL78 HEK-293T C1314(0.99); C691(0.99)  LDD1674  [4]
 LDCM0472  CL79 HEK-293T C1314(1.12); C193(1.00)  LDD1675  [4]
 LDCM0473  CL8 HCT 116 C1012(1.53)  LDD0790  [1]
 LDCM0474  CL80 HEK-293T C193(1.02)  LDD1677  [4]
 LDCM0475  CL81 HEK-293T C710(0.90); C691(1.15); C1012(0.98)  LDD1678  [4]
 LDCM0476  CL82 HEK-293T C1314(1.25); C691(1.06); C1012(1.03)  LDD1679  [4]
 LDCM0477  CL83 HEK-293T C193(0.89); C1012(1.06)  LDD1680  [4]
 LDCM0478  CL84 HEK-293T C691(1.05)  LDD1681  [4]
 LDCM0479  CL85 HEK-293T C710(0.84)  LDD1682  [4]
 LDCM0480  CL86 HEK-293T C1314(1.10)  LDD1683  [4]
 LDCM0481  CL87 HEK-293T C193(0.99)  LDD1684  [4]
 LDCM0482  CL88 HEK-293T C1314(1.02); C193(1.03)  LDD1685  [4]
 LDCM0483  CL89 HEK-293T C710(0.97); C1314(1.02); C193(1.08)  LDD1686  [4]
 LDCM0484  CL9 HCT 116 C1012(1.05)  LDD0801  [1]
 LDCM0485  CL90 HEK-293T C1314(1.22); C691(1.24)  LDD1688  [4]
 LDCM0486  CL91 HCT 116 C1012(1.00)  LDD0803  [1]
 LDCM0487  CL92 HCT 116 C1012(1.11)  LDD0804  [1]
 LDCM0488  CL93 HCT 116 C1012(0.82)  LDD0805  [1]
 LDCM0489  CL94 HCT 116 C1012(0.99)  LDD0806  [1]
 LDCM0490  CL95 HCT 116 C1012(1.14)  LDD0807  [1]
 LDCM0491  CL96 HCT 116 C1012(0.89)  LDD0808  [1]
 LDCM0492  CL97 HCT 116 C1012(0.91)  LDD0809  [1]
 LDCM0493  CL98 HCT 116 C1012(1.00)  LDD0810  [1]
 LDCM0494  CL99 HCT 116 C1012(1.12)  LDD0811  [1]
 LDCM0495  E2913 HEK-293T C193(1.12)  LDD1698  [4]
 LDCM0468  Fragment33 HEK-293T C193(1.11)  LDD1671  [4]
 LDCM0427  Fragment51 HEK-293T C1314(0.92)  LDD1631  [4]
 LDCM0022  KB02 HCT 116 C1012(1.50); C1091(3.45); C1097(3.45)  LDD0080  [1]
 LDCM0023  KB03 HCT 116 C1012(1.87); C1091(2.05); C1097(2.05)  LDD0081  [1]
 LDCM0024  KB05 HCT 116 C1012(2.97); C1091(2.38); C1097(2.38)  LDD0082  [1]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 4 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Ubiquitin carboxyl-terminal hydrolase 7 (USP7) Peptidase C19 family Q93009
Dual specificity mitogen-activated protein kinase kinase 4 (MAP2K4) STE Ser/Thr protein kinase family P45985
Mitogen-activated protein kinase kinase kinase kinase 2 (MAP4K2) STE Ser/Thr protein kinase family Q12851
Serine/threonine-protein kinase B-raf (BRAF) TKL Ser/Thr protein kinase family P15056
Transporter and channel
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Filamin-B (FLNB) Filamin family O75369
Other
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
DDB1- and CUL4-associated factor 7 (DCAF7) WD repeat DCAF7 family P61962

The Drug(s) Related To This Target

Approved
Click To Hide/Show 2 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Binimetinib Small molecular drug DB11967
Fostamatinib Small molecular drug DB12010
Investigative
Click To Hide/Show 5 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Azd-8330 Small molecular drug DB06061
Ci-1040 Small molecular drug D0B9BU
Llz16406 Small molecular drug D0C7LR
U0126 Small molecular drug D0GD8Y
Ro092210 . D0C1OZ

References

1 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
2 Targeted Proteomic Approaches for Proteome-Wide Characterizations of the AMP-Binding Capacities of Kinases. J Proteome Res. 2022 Aug 5;21(8):2063-2070. doi: 10.1021/acs.jproteome.2c00225. Epub 2022 Jul 12.
3 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
4 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402