Details of the Target

General Information of Target

Target ID LDTP05747
Target Name Intraflagellar transport protein 88 homolog (IFT88)
Gene Name IFT88
Gene ID 8100
Synonyms
TG737; TTC10; Intraflagellar transport protein 88 homolog; Recessive polycystic kidney disease protein Tg737 homolog; Tetratricopeptide repeat protein 10; TPR repeat protein 10
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MMQNVHLAPETDEDDLYSGYNDYNPIYDIEELENDAAFQQAVRTSHGRRPPITAKISSTA
VTRPIATGYGSKTSLASSIGRPMTGAIQDGVTRPMTAVRAAGFTKAALRGSAFDPLSQSR
GPASPLEAKKKDSPEEKIKQLEKEVNELVEESCIANSCGDLKLALEKAKDAGRKERVLVR
QREQVTTPENINLDLTYSVLFNLASQYSVNEMYAEALNTYQVIVKNKMFSNAGILKMNMG
NIYLKQRNYSKAIKFYRMALDQVPSVNKQMRIKIMQNIGVTFIQAGQYSDAINSYEHIMS
MAPNLKAGYNLTICYFAIGDREKMKKAFQKLITVPLEIDEDKYISPSDDPHTNLVTEAIK
NDHLRQMERERKAMAEKYIMTSAKLIAPVIETSFAAGYDWCVEVVKASQYVELANDLEIN
KAVTYLRQKDYNQAVEILKVLEKKDSRVKSAAATNLSALYYMGKDFAQASSYADIAVNSD
RYNPAALTNKGNTVFANGDYEKAAEFYKEALRNDSSCTEALYNIGLTYEKLNRLDEALDC
FLKLHAILRNSAEVLYQIANIYELMENPSQAIEWLMQVVSVIPTDPQVLSKLGELYDREG
DKSQAFQYYYESYRYFPCNIEVIEWLGAYYIDTQFWEKAIQYFERASLIQPTQVKWQLMV
ASCFRRSGNYQKALDTYKDTHRKFPENVECLRFLVRLCTDLGLKDAQEYARKLKRLEKMK
EIREQRIKSGRDGSGGSRGKREGSASGDSGQNYSASSKGERLSARLRALPGTNEPYESSS
NKEIDASYVDPLGPQIERPKTAAKKRIDEDDFADEELGDDLLPE
Target Bioclass
Transporter and channel
Subcellular location
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole
Function Positively regulates primary cilium biogenesis. Also involved in autophagy since it is required for trafficking of ATG16L and the expansion of the autophagic compartment.
Uniprot ID
Q13099
Ensemble ID
ENST00000319980.10
HGNC ID
HGNC:20606

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 3 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C549(32.19)  LDD0204  [1]
IA-alkyne
 Probe Info  		N.A.  LDD0165  [2]
IPM
 Probe Info  		N.A.  LDD2156  [3]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 PaTu 8988t C549(0.50)  LDD1093  [4]
 LDCM0215  AC10 PaTu 8988t C549(1.37)  LDD1094  [4]
 LDCM0216  AC100 HEK-293T C549(0.90)  LDD0814  [4]
 LDCM0217  AC101 HEK-293T C549(0.96)  LDD0815  [4]
 LDCM0218  AC102 HEK-293T C549(1.08)  LDD0816  [4]
 LDCM0219  AC103 HEK-293T C549(0.97)  LDD0817  [4]
 LDCM0220  AC104 HEK-293T C549(1.10)  LDD0818  [4]
 LDCM0221  AC105 HEK-293T C549(0.88)  LDD0819  [4]
 LDCM0222  AC106 HEK-293T C549(1.21)  LDD0820  [4]
 LDCM0223  AC107 HEK-293T C549(0.78)  LDD0821  [4]
 LDCM0224  AC108 HEK-293T C549(1.22)  LDD0822  [4]
 LDCM0225  AC109 HEK-293T C549(0.91)  LDD0823  [4]
 LDCM0226  AC11 PaTu 8988t C549(1.25)  LDD1105  [4]
 LDCM0227  AC110 HEK-293T C549(0.79)  LDD0825  [4]
 LDCM0228  AC111 HEK-293T C549(0.69)  LDD0826  [4]
 LDCM0229  AC112 HEK-293T C549(0.89)  LDD0827  [4]
 LDCM0230  AC113 HEK-293T C549(1.60)  LDD0828  [4]
 LDCM0231  AC114 HEK-293T C549(0.99)  LDD0829  [4]
 LDCM0232  AC115 HEK-293T C549(1.13)  LDD0830  [4]
 LDCM0233  AC116 HEK-293T C549(1.41)  LDD0831  [4]
 LDCM0234  AC117 HEK-293T C549(1.15)  LDD0832  [4]
 LDCM0235  AC118 HEK-293T C549(1.07)  LDD0833  [4]
 LDCM0236  AC119 HEK-293T C549(1.50)  LDD0834  [4]
 LDCM0237  AC12 PaTu 8988t C549(1.04)  LDD1116  [4]
 LDCM0238  AC120 HEK-293T C549(2.02)  LDD0836  [4]
 LDCM0239  AC121 HEK-293T C549(1.45)  LDD0837  [4]
 LDCM0240  AC122 HEK-293T C549(1.34)  LDD0838  [4]
 LDCM0241  AC123 HEK-293T C549(1.24)  LDD0839  [4]
 LDCM0242  AC124 HEK-293T C549(1.41)  LDD0840  [4]
 LDCM0243  AC125 HEK-293T C549(1.17)  LDD0841  [4]
 LDCM0244  AC126 HEK-293T C549(1.44)  LDD0842  [4]
 LDCM0245  AC127 HEK-293T C549(1.31)  LDD0843  [4]
 LDCM0246  AC128 HEK-293T C549(1.03)  LDD0844  [4]
 LDCM0247  AC129 HEK-293T C549(0.92)  LDD0845  [4]
 LDCM0249  AC130 HEK-293T C549(1.50)  LDD0847  [4]
 LDCM0250  AC131 HEK-293T C549(1.30)  LDD0848  [4]
 LDCM0251  AC132 HEK-293T C549(1.05)  LDD0849  [4]
 LDCM0252  AC133 HEK-293T C549(0.99)  LDD0850  [4]
 LDCM0253  AC134 HEK-293T C549(0.99)  LDD0851  [4]
 LDCM0254  AC135 HEK-293T C549(1.54)  LDD0852  [4]
 LDCM0255  AC136 HEK-293T C549(1.19)  LDD0853  [4]
 LDCM0256  AC137 HEK-293T C549(1.00)  LDD0854  [4]
 LDCM0257  AC138 HEK-293T C549(1.02)  LDD0855  [4]
 LDCM0258  AC139 HEK-293T C549(1.29)  LDD0856  [4]
 LDCM0259  AC14 PaTu 8988t C549(1.16)  LDD1138  [4]
 LDCM0260  AC140 HEK-293T C549(1.22)  LDD0858  [4]
 LDCM0261  AC141 HEK-293T C549(1.15)  LDD0859  [4]
 LDCM0262  AC142 HEK-293T C549(1.35)  LDD0860  [4]
 LDCM0270  AC15 PaTu 8988t C549(1.30)  LDD1149  [4]
 LDCM0276  AC17 PaTu 8988t C549(0.96)  LDD1155  [4]
 LDCM0277  AC18 PaTu 8988t C549(1.06)  LDD1156  [4]
 LDCM0278  AC19 PaTu 8988t C549(1.02)  LDD1157  [4]
 LDCM0279  AC2 PaTu 8988t C549(0.50)  LDD1158  [4]
 LDCM0280  AC20 PaTu 8988t C549(1.00)  LDD1159  [4]
 LDCM0281  AC21 PaTu 8988t C549(1.06)  LDD1160  [4]
 LDCM0282  AC22 PaTu 8988t C549(1.07)  LDD1161  [4]
 LDCM0283  AC23 PaTu 8988t C549(1.04)  LDD1162  [4]
 LDCM0284  AC24 PaTu 8988t C549(1.07)  LDD1163  [4]
 LDCM0285  AC25 HEK-293T C549(1.27)  LDD0883  [4]
 LDCM0286  AC26 HEK-293T C549(1.11)  LDD0884  [4]
 LDCM0287  AC27 HEK-293T C549(1.39)  LDD0885  [4]
 LDCM0288  AC28 HEK-293T C549(1.03)  LDD0886  [4]
 LDCM0289  AC29 HEK-293T C549(0.73)  LDD0887  [4]
 LDCM0290  AC3 PaTu 8988t C549(0.49)  LDD1169  [4]
 LDCM0291  AC30 HEK-293T C549(0.82)  LDD0889  [4]
 LDCM0292  AC31 HEK-293T C549(1.55)  LDD0890  [4]
 LDCM0293  AC32 HEK-293T C549(1.13)  LDD0891  [4]
 LDCM0294  AC33 HEK-293T C549(0.79)  LDD0892  [4]
 LDCM0295  AC34 HEK-293T C549(0.77)  LDD0893  [4]
 LDCM0296  AC35 PaTu 8988t C549(1.10)  LDD1175  [4]
 LDCM0297  AC36 PaTu 8988t C549(1.17)  LDD1176  [4]
 LDCM0298  AC37 PaTu 8988t C549(0.93)  LDD1177  [4]
 LDCM0299  AC38 PaTu 8988t C549(1.27)  LDD1178  [4]
 LDCM0300  AC39 PaTu 8988t C549(1.25)  LDD1179  [4]
 LDCM0301  AC4 PaTu 8988t C549(0.46)  LDD1180  [4]
 LDCM0302  AC40 PaTu 8988t C549(1.27)  LDD1181  [4]
 LDCM0303  AC41 PaTu 8988t C549(0.93)  LDD1182  [4]
 LDCM0304  AC42 PaTu 8988t C549(0.97)  LDD1183  [4]
 LDCM0305  AC43 PaTu 8988t C549(0.93)  LDD1184  [4]
 LDCM0306  AC44 PaTu 8988t C549(1.03)  LDD1185  [4]
 LDCM0307  AC45 PaTu 8988t C549(0.97)  LDD1186  [4]
 LDCM0308  AC46 PaTu 8988t C549(0.95)  LDD1187  [4]
 LDCM0309  AC47 PaTu 8988t C549(0.98)  LDD1188  [4]
 LDCM0310  AC48 PaTu 8988t C549(1.06)  LDD1189  [4]
 LDCM0311  AC49 PaTu 8988t C549(0.97)  LDD1190  [4]
 LDCM0312  AC5 PaTu 8988t C549(0.51)  LDD1191  [4]
 LDCM0313  AC50 PaTu 8988t C549(0.96)  LDD1192  [4]
 LDCM0314  AC51 PaTu 8988t C549(0.93)  LDD1193  [4]
 LDCM0315  AC52 PaTu 8988t C549(0.93)  LDD1194  [4]
 LDCM0316  AC53 PaTu 8988t C549(1.13)  LDD1195  [4]
 LDCM0317  AC54 PaTu 8988t C549(1.20)  LDD1196  [4]
 LDCM0318  AC55 PaTu 8988t C549(1.04)  LDD1197  [4]
 LDCM0319  AC56 PaTu 8988t C549(1.12)  LDD1198  [4]
 LDCM0320  AC57 HEK-293T C549(0.99)  LDD0918  [4]
 LDCM0321  AC58 HEK-293T C549(0.90)  LDD0919  [4]
 LDCM0322  AC59 HEK-293T C549(1.05)  LDD0920  [4]
 LDCM0323  AC6 PaTu 8988t C549(0.99)  LDD1202  [4]
 LDCM0324  AC60 HEK-293T C549(3.76)  LDD0922  [4]
 LDCM0325  AC61 HEK-293T C549(0.97)  LDD0923  [4]
 LDCM0326  AC62 HEK-293T C549(0.95)  LDD0924  [4]
 LDCM0327  AC63 HEK-293T C549(1.07)  LDD0925  [4]
 LDCM0328  AC64 HEK-293T C549(0.92)  LDD0926  [4]
 LDCM0329  AC65 HEK-293T C549(0.86)  LDD0927  [4]
 LDCM0330  AC66 HEK-293T C549(0.87)  LDD0928  [4]
 LDCM0331  AC67 HEK-293T C549(0.76)  LDD0929  [4]
 LDCM0332  AC68 PaTu 8988t C549(0.97)  LDD1211  [4]
 LDCM0333  AC69 PaTu 8988t C549(1.05)  LDD1212  [4]
 LDCM0334  AC7 PaTu 8988t C549(1.04)  LDD1213  [4]
 LDCM0335  AC70 PaTu 8988t C549(1.07)  LDD1214  [4]
 LDCM0336  AC71 PaTu 8988t C549(1.07)  LDD1215  [4]
 LDCM0337  AC72 PaTu 8988t C549(0.97)  LDD1216  [4]
 LDCM0338  AC73 PaTu 8988t C549(0.92)  LDD1217  [4]
 LDCM0339  AC74 PaTu 8988t C549(1.03)  LDD1218  [4]
 LDCM0340  AC75 PaTu 8988t C549(0.96)  LDD1219  [4]
 LDCM0341  AC76 PaTu 8988t C549(1.00)  LDD1220  [4]
 LDCM0342  AC77 PaTu 8988t C549(1.02)  LDD1221  [4]
 LDCM0343  AC78 PaTu 8988t C549(1.02)  LDD1222  [4]
 LDCM0344  AC79 PaTu 8988t C549(1.18)  LDD1223  [4]
 LDCM0345  AC8 PaTu 8988t C549(1.25)  LDD1224  [4]
 LDCM0346  AC80 PaTu 8988t C549(1.01)  LDD1225  [4]
 LDCM0347  AC81 PaTu 8988t C549(0.96)  LDD1226  [4]
 LDCM0348  AC82 PaTu 8988t C549(0.99)  LDD1227  [4]
 LDCM0349  AC83 HEK-293T C549(0.84)  LDD0947  [4]
 LDCM0350  AC84 HEK-293T C549(1.19)  LDD0948  [4]
 LDCM0351  AC85 HEK-293T C549(0.94)  LDD0949  [4]
 LDCM0352  AC86 HEK-293T C549(0.88)  LDD0950  [4]
 LDCM0353  AC87 HEK-293T C549(1.45)  LDD0951  [4]
 LDCM0354  AC88 HEK-293T C549(1.18)  LDD0952  [4]
 LDCM0355  AC89 HEK-293T C549(1.35)  LDD0953  [4]
 LDCM0357  AC90 HEK-293T C549(1.13)  LDD0955  [4]
 LDCM0358  AC91 HEK-293T C549(1.31)  LDD0956  [4]
 LDCM0359  AC92 HEK-293T C549(0.89)  LDD0957  [4]
 LDCM0360  AC93 HEK-293T C549(0.92)  LDD0958  [4]
 LDCM0361  AC94 HEK-293T C549(1.50)  LDD0959  [4]
 LDCM0362  AC95 HEK-293T C549(1.18)  LDD0960  [4]
 LDCM0363  AC96 HEK-293T C549(1.17)  LDD0961  [4]
 LDCM0364  AC97 HEK-293T C549(0.97)  LDD0962  [4]
 LDCM0365  AC98 HEK-293T C549(0.98)  LDD0963  [4]
 LDCM0366  AC99 HEK-293T C549(1.09)  LDD0964  [4]
 LDCM0248  AKOS034007472 PaTu 8988t C549(1.39)  LDD1127  [4]
 LDCM0356  AKOS034007680 PaTu 8988t C549(1.16)  LDD1235  [4]
 LDCM0275  AKOS034007705 PaTu 8988t C549(1.19)  LDD1154  [4]
 LDCM0102  BDHI 8 Jurkat C549(32.19)  LDD0204  [1]
 LDCM0367  CL1 PaTu 8988t C549(1.01)  LDD1246  [4]
 LDCM0368  CL10 PaTu 8988t C549(1.20)  LDD1247  [4]
 LDCM0369  CL100 PaTu 8988t C549(0.50)  LDD1248  [4]
 LDCM0370  CL101 PaTu 8988t C549(0.99)  LDD1249  [4]
 LDCM0371  CL102 PaTu 8988t C549(0.98)  LDD1250  [4]
 LDCM0372  CL103 PaTu 8988t C549(1.52)  LDD1251  [4]
 LDCM0373  CL104 PaTu 8988t C549(1.03)  LDD1252  [4]
 LDCM0374  CL105 PaTu 8988t C549(0.95)  LDD1253  [4]
 LDCM0375  CL106 PaTu 8988t C549(0.92)  LDD1254  [4]
 LDCM0376  CL107 PaTu 8988t C549(1.01)  LDD1255  [4]
 LDCM0377  CL108 PaTu 8988t C549(0.97)  LDD1256  [4]
 LDCM0378  CL109 PaTu 8988t C549(0.97)  LDD1257  [4]
 LDCM0379  CL11 PaTu 8988t C549(1.01)  LDD1258  [4]
 LDCM0380  CL110 PaTu 8988t C549(1.05)  LDD1259  [4]
 LDCM0381  CL111 PaTu 8988t C549(1.17)  LDD1260  [4]
 LDCM0382  CL112 HEK-293T C549(1.26)  LDD0980  [4]
 LDCM0383  CL113 HEK-293T C549(1.05)  LDD0981  [4]
 LDCM0384  CL114 HEK-293T C549(1.00)  LDD0982  [4]
 LDCM0385  CL115 HEK-293T C549(0.60)  LDD0983  [4]
 LDCM0386  CL116 HEK-293T C549(0.78)  LDD0984  [4]
 LDCM0387  CL117 PaTu 8988t C549(1.07)  LDD1266  [4]
 LDCM0388  CL118 PaTu 8988t C549(1.08)  LDD1267  [4]
 LDCM0389  CL119 PaTu 8988t C549(0.97)  LDD1268  [4]
 LDCM0390  CL12 PaTu 8988t C549(0.90)  LDD1269  [4]
 LDCM0391  CL120 PaTu 8988t C549(0.95)  LDD1270  [4]
 LDCM0392  CL121 PaTu 8988t C549(1.00)  LDD1271  [4]
 LDCM0393  CL122 PaTu 8988t C549(0.83)  LDD1272  [4]
 LDCM0394  CL123 PaTu 8988t C549(1.02)  LDD1273  [4]
 LDCM0395  CL124 PaTu 8988t C549(0.96)  LDD1274  [4]
 LDCM0396  CL125 HEK-293T C549(1.21)  LDD0994  [4]
 LDCM0397  CL126 HEK-293T C549(0.96)  LDD0995  [4]
 LDCM0398  CL127 HEK-293T C549(0.76)  LDD0996  [4]
 LDCM0399  CL128 HEK-293T C549(0.81)  LDD0997  [4]
 LDCM0400  CL13 PaTu 8988t C549(1.49)  LDD1279  [4]
 LDCM0401  CL14 PaTu 8988t C549(1.34)  LDD1280  [4]
 LDCM0402  CL15 PaTu 8988t C549(1.01)  LDD1281  [4]
 LDCM0403  CL16 HEK-293T C698(1.16); C540(0.92); C690(1.18)  LDD1607  [5]
 LDCM0404  CL17 HEK-293T C698(0.92); C540(0.96)  LDD1608  [5]
 LDCM0405  CL18 HEK-293T C540(0.83); C690(1.18)  LDD1609  [5]
 LDCM0406  CL19 HEK-293T C540(0.81)  LDD1610  [5]
 LDCM0407  CL2 PaTu 8988t C549(0.89)  LDD1286  [4]
 LDCM0408  CL20 HEK-293T C698(1.16); C540(0.89); C663(0.92)  LDD1612  [5]
 LDCM0409  CL21 HEK-293T C540(0.87)  LDD1613  [5]
 LDCM0410  CL22 HEK-293T C698(1.08); C540(0.87)  LDD1614  [5]
 LDCM0411  CL23 HEK-293T C698(1.14); C540(0.86)  LDD1615  [5]
 LDCM0412  CL24 HEK-293T C698(1.16); C540(0.81)  LDD1616  [5]
 LDCM0413  CL25 HEK-293T C698(1.08); C540(1.09)  LDD1617  [5]
 LDCM0414  CL26 HEK-293T C698(0.96); C540(1.03)  LDD1618  [5]
 LDCM0415  CL27 HEK-293T C698(1.08); C540(0.92)  LDD1619  [5]
 LDCM0416  CL28 HEK-293T C698(1.05); C540(0.97); C690(1.15)  LDD1620  [5]
 LDCM0417  CL29 HEK-293T C698(1.09); C540(0.85)  LDD1621  [5]
 LDCM0418  CL3 PaTu 8988t C549(1.27)  LDD1297  [4]
 LDCM0419  CL30 HEK-293T C540(0.85); C690(1.12)  LDD1623  [5]
 LDCM0420  CL31 HEK-293T C540(0.89)  LDD1624  [5]
 LDCM0421  CL32 HEK-293T C698(1.04); C540(0.97); C663(0.84)  LDD1625  [5]
 LDCM0422  CL33 HEK-293T C540(0.98)  LDD1626  [5]
 LDCM0423  CL34 HEK-293T C698(1.07); C540(0.90)  LDD1627  [5]
 LDCM0424  CL35 HEK-293T C698(1.02); C540(0.93)  LDD1628  [5]
 LDCM0425  CL36 HEK-293T C698(1.05); C540(1.00)  LDD1629  [5]
 LDCM0426  CL37 HEK-293T C698(0.99); C540(0.93)  LDD1630  [5]
 LDCM0428  CL39 HEK-293T C698(1.04); C540(0.86)  LDD1632  [5]
 LDCM0429  CL4 PaTu 8988t C549(1.26)  LDD1308  [4]
 LDCM0430  CL40 HEK-293T C698(1.13); C540(0.96); C690(1.11)  LDD1634  [5]
 LDCM0431  CL41 HEK-293T C698(0.95); C540(0.97)  LDD1635  [5]
 LDCM0432  CL42 HEK-293T C540(0.87); C690(1.14)  LDD1636  [5]
 LDCM0433  CL43 HEK-293T C540(0.62)  LDD1637  [5]
 LDCM0434  CL44 HEK-293T C698(1.02); C540(1.03); C663(0.80)  LDD1638  [5]
 LDCM0435  CL45 HEK-293T C540(0.85)  LDD1639  [5]
 LDCM0436  CL46 PaTu 8988t C549(1.00)  LDD1315  [4]
 LDCM0437  CL47 PaTu 8988t C549(0.95)  LDD1316  [4]
 LDCM0438  CL48 PaTu 8988t C549(0.96)  LDD1317  [4]
 LDCM0439  CL49 PaTu 8988t C549(0.91)  LDD1318  [4]
 LDCM0440  CL5 PaTu 8988t C549(1.49)  LDD1319  [4]
 LDCM0441  CL50 PaTu 8988t C549(0.99)  LDD1320  [4]
 LDCM0442  CL51 PaTu 8988t C549(1.04)  LDD1321  [4]
 LDCM0443  CL52 PaTu 8988t C549(0.90)  LDD1322  [4]
 LDCM0444  CL53 PaTu 8988t C549(0.91)  LDD1323  [4]
 LDCM0445  CL54 PaTu 8988t C549(1.04)  LDD1324  [4]
 LDCM0446  CL55 PaTu 8988t C549(1.00)  LDD1325  [4]
 LDCM0447  CL56 PaTu 8988t C549(0.24)  LDD1326  [4]
 LDCM0448  CL57 PaTu 8988t C549(1.60)  LDD1327  [4]
 LDCM0449  CL58 PaTu 8988t C549(1.09)  LDD1328  [4]
 LDCM0450  CL59 PaTu 8988t C549(1.62)  LDD1329  [4]
 LDCM0451  CL6 PaTu 8988t C549(1.02)  LDD1330  [4]
 LDCM0452  CL60 PaTu 8988t C549(1.30)  LDD1331  [4]
 LDCM0453  CL61 PaTu 8988t C549(1.08)  LDD1332  [4]
 LDCM0454  CL62 PaTu 8988t C549(1.16)  LDD1333  [4]
 LDCM0455  CL63 PaTu 8988t C549(1.03)  LDD1334  [4]
 LDCM0456  CL64 PaTu 8988t C549(1.04)  LDD1335  [4]
 LDCM0457  CL65 PaTu 8988t C549(1.08)  LDD1336  [4]
 LDCM0458  CL66 PaTu 8988t C549(1.10)  LDD1337  [4]
 LDCM0459  CL67 PaTu 8988t C549(1.13)  LDD1338  [4]
 LDCM0460  CL68 PaTu 8988t C549(1.23)  LDD1339  [4]
 LDCM0461  CL69 PaTu 8988t C549(1.24)  LDD1340  [4]
 LDCM0462  CL7 PaTu 8988t C549(1.25)  LDD1341  [4]
 LDCM0463  CL70 PaTu 8988t C549(1.19)  LDD1342  [4]
 LDCM0464  CL71 PaTu 8988t C549(1.03)  LDD1343  [4]
 LDCM0465  CL72 PaTu 8988t C549(1.10)  LDD1344  [4]
 LDCM0466  CL73 PaTu 8988t C549(1.25)  LDD1345  [4]
 LDCM0467  CL74 PaTu 8988t C549(1.08)  LDD1346  [4]
 LDCM0469  CL76 HEK-293T C698(1.04); C540(1.01); C690(1.13)  LDD1672  [5]
 LDCM0470  CL77 HEK-293T C698(1.03); C540(1.05)  LDD1673  [5]
 LDCM0471  CL78 HEK-293T C540(0.87); C690(1.14)  LDD1674  [5]
 LDCM0472  CL79 HEK-293T C540(0.99)  LDD1675  [5]
 LDCM0473  CL8 PaTu 8988t C549(1.37)  LDD1352  [4]
 LDCM0474  CL80 HEK-293T C698(1.08); C540(1.01); C663(0.79)  LDD1677  [5]
 LDCM0475  CL81 HEK-293T C540(0.93)  LDD1678  [5]
 LDCM0476  CL82 HEK-293T C698(1.04); C540(1.00)  LDD1679  [5]
 LDCM0477  CL83 HEK-293T C698(1.07); C540(1.02)  LDD1680  [5]
 LDCM0478  CL84 HEK-293T C698(1.12); C540(1.17)  LDD1681  [5]
 LDCM0479  CL85 HEK-293T C698(1.12); C540(0.84)  LDD1682  [5]
 LDCM0480  CL86 HEK-293T C698(1.25); C540(0.98)  LDD1683  [5]
 LDCM0481  CL87 HEK-293T C698(1.23); C540(0.82)  LDD1684  [5]
 LDCM0482  CL88 HEK-293T C698(1.11); C540(1.00); C690(1.18)  LDD1685  [5]
 LDCM0483  CL89 HEK-293T C698(0.97); C540(0.88)  LDD1686  [5]
 LDCM0484  CL9 PaTu 8988t C549(1.08)  LDD1363  [4]
 LDCM0485  CL90 HEK-293T C540(1.28); C690(1.28)  LDD1688  [5]
 LDCM0486  CL91 PaTu 8988t C549(0.47)  LDD1365  [4]
 LDCM0487  CL92 PaTu 8988t C549(0.46)  LDD1366  [4]
 LDCM0488  CL93 PaTu 8988t C549(0.45)  LDD1367  [4]
 LDCM0489  CL94 PaTu 8988t C549(0.44)  LDD1368  [4]
 LDCM0490  CL95 PaTu 8988t C549(0.49)  LDD1369  [4]
 LDCM0491  CL96 PaTu 8988t C549(0.46)  LDD1370  [4]
 LDCM0492  CL97 PaTu 8988t C549(0.48)  LDD1371  [4]
 LDCM0493  CL98 PaTu 8988t C549(0.45)  LDD1372  [4]
 LDCM0494  CL99 PaTu 8988t C549(0.48)  LDD1373  [4]
 LDCM0495  E2913 HEK-293T C698(1.15); C540(0.88)  LDD1698  [5]
 LDCM0468  Fragment33 PaTu 8988t C549(1.00)  LDD1347  [4]
 LDCM0427  Fragment51 HEK-293T C698(1.04); C540(0.90)  LDD1631  [5]
 LDCM0022  KB02 HEK-293T C698(1.08); C540(1.14)  LDD1492  [5]
 LDCM0023  KB03 HEK-293T C698(1.02); C540(0.98)  LDD1497  [5]
 LDCM0024  KB05 OAW-42 C707(3.27)  LDD3369  [6]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 4 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Protein-lysine N-methyltransferase EEF2KMT (EEF2KMT) EEF2KMT family Q96G04
Inositol-trisphosphate 3-kinase B (ITPKB) Inositol phosphokinase (IPK) family P27987
Methionine-R-sulfoxide reductase B1 (MSRB1) MsrB Met sulfoxide reductase family Q9NZV6
Calpain-7 (CAPN7) Peptidase C2 family Q9Y6W3
Transcription factor
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily E member 1 (SMARCE1) . Q969G3
Other
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Coiled-coil domain-containing protein 120 (CCDC120) . Q96HB5

References

1 Covalent Inhibition by a Natural Product-Inspired Latent Electrophile. J Am Chem Soc. 2023 May 24;145(20):11097-11109. doi: 10.1021/jacs.3c00598. Epub 2023 May 15.
2 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
3 Benchmarking Cleavable Biotin Tags for Peptide-Centric Chemoproteomics. J Proteome Res. 2022 May 6;21(5):1349-1358. doi: 10.1021/acs.jproteome.2c00174. Epub 2022 Apr 25.
Mass spectrometry data entry: PXD031019
4 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
5 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
6 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840