Details of the Target

General Information of Target

Target ID LDTP05706
Target Name Disks large homolog 1 (DLG1)
Gene Name DLG1
Gene ID 1739
Synonyms
Disks large homolog 1; Synapse-associated protein 97; SAP-97; SAP97; hDlg
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MPVRKQDTQRALHLLEEYRSKLSQTEDRQLRSSIERVINIFQSNLFQALIDIQEFYEVTL
LDNPKCIDRSKPSEPIQPVNTWEISSLPSSTVTSETLPSSLSPSVEKYRYQDEDTPPQEH
ISPQITNEVIGPELVHVSEKNLSEIENVHGFVSHSHISPIKPTEAVLPSPPTVPVIPVLP
VPAENTVILPTIPQANPPPVLVNTDSLETPTYVNGTDADYEYEEITLERGNSGLGFSIAG
GTDNPHIGDDSSIFITKIITGGAAAQDGRLRVNDCILRVNEVDVRDVTHSKAVEALKEAG
SIVRLYVKRRKPVSEKIMEIKLIKGPKGLGFSIAGGVGNQHIPGDNSIYVTKIIEGGAAH
KDGKLQIGDKLLAVNNVCLEEVTHEEAVTALKNTSDFVYLKVAKPTSMYMNDGYAPPDIT
NSSSQPVDNHVSPSSFLGQTPASPARYSPVSKAVLGDDEITREPRKVVLHRGSTGLGFNI
VGGEDGEGIFISFILAGGPADLSGELRKGDRIISVNSVDLRAASHEQAAAALKNAGQAVT
IVAQYRPEEYSRFEAKIHDLREQMMNSSISSGSGSLRTSQKRSLYVRALFDYDKTKDSGL
PSQGLNFKFGDILHVINASDDEWWQARQVTPDGESDEVGVIPSKRRVEKKERARLKTVKF
NSKTRDKGEIPDDMGSKGLKHVTSNASDSESSYRGQEEYVLSYEPVNQQEVNYTRPVIIL
GPMKDRINDDLISEFPDKFGSCVPHTTRPKRDYEVDGRDYHFVTSREQMEKDIQEHKFIE
AGQYNNHLYGTSVQSVREVAEKGKHCILDVSGNAIKRLQIAQLYPISIFIKPKSMENIME
MNKRLTEEQARKTFERAMKLEQEFTEHFTAIVQGDTLEDIYNQVKQIIEEQSGSYIWVPA
KEKL
Target Bioclass
Transporter and channel
Family
MAGUK family
Subcellular location
Membrane
Function
Essential multidomain scaffolding protein required for normal development. Recruits channels, receptors and signaling molecules to discrete plasma membrane domains in polarized cells. May play a role in adherens junction assembly, signal transduction, cell proliferation, synaptogenesis and lymphocyte activation. Regulates the excitability of cardiac myocytes by modulating the functional expression of Kv4 channels. Functional regulator of Kv1.5 channel. During long-term depression in hippocampal neurons, it recruits ADAM10 to the plasma membrane.
Uniprot ID
Q12959
Ensemble ID
ENST00000346964.6
HGNC ID
HGNC:2900

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 22 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		15.00  LDD0402  [1]
ONAyne
 Probe Info  		K556(5.00)  LDD0274  [2]
STPyne
 Probe Info  		K321(8.78); K361(8.98); K663(3.96)  LDD0277  [2]
Probe 1
 Probe Info  		Y789(9.67)  LDD3495  [3]
DBIA
 Probe Info  		C378(3.11)  LDD3312  [4]
BTD
 Probe Info  		C378(0.86)  LDD2092  [5]
HHS-475
 Probe Info  		Y760(1.42)  LDD0264  [6]
HHS-465
 Probe Info  		Y760(0.53)  LDD2237  [7]
Acrolein
 Probe Info  		N.A.  LDD0221  [8]
ATP probe
 Probe Info  		K816(0.00); K680(0.00)  LDD0199  [9]
4-Iodoacetamidophenylacetylene
 Probe Info  		N.A.  LDD0038  [10]
IA-alkyne
 Probe Info  		N.A.  LDD0036  [10]
Lodoacetamide azide
 Probe Info  		C378(0.00); C275(0.00)  LDD0037  [10]
WYneN
 Probe Info  		N.A.  LDD0021  [11]
Compound 10
 Probe Info  		N.A.  LDD2216  [12]
Compound 11
 Probe Info  		N.A.  LDD2213  [12]
IPM
 Probe Info  		N.A.  LDD0005  [11]
SF
 Probe Info  		Y789(0.00); Y760(0.00)  LDD0028  [13]
TFBX
 Probe Info  		N.A.  LDD0148  [14]
Phosphinate-6
 Probe Info  		N.A.  LDD0018  [15]
NAIA_5
 Probe Info  		C806(0.00); C742(0.00); C378(0.00)  LDD2223  [16]
HHS-482
 Probe Info  		Y760(0.59)  LDD2239  [7]
PAL-AfBPP Probe
Click To Hide/Show 2 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C158
 Probe Info  		9.06  LDD1838  [17]
C160
 Probe Info  		11.47  LDD1840  [17]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0558  2-Cyano-N-phenylacetamide MDA-MB-231 C742(1.28)  LDD2152  [5]
 LDCM0214  AC1 HEK-293T C275(0.81); C378(1.09)  LDD1507  [18]
 LDCM0215  AC10 HEK-293T C275(1.01); C378(0.98)  LDD1508  [18]
 LDCM0226  AC11 HEK-293T C275(0.78); C378(0.99)  LDD1509  [18]
 LDCM0237  AC12 HEK-293T C275(1.01); C378(1.04)  LDD1510  [18]
 LDCM0259  AC14 HEK-293T C275(0.99); C378(1.02)  LDD1512  [18]
 LDCM0270  AC15 HEK-293T C275(1.03); C378(0.91)  LDD1513  [18]
 LDCM0276  AC17 HEK-293T C275(0.97); C378(1.15)  LDD1515  [18]
 LDCM0277  AC18 HEK-293T C275(0.92); C378(1.03)  LDD1516  [18]
 LDCM0278  AC19 HEK-293T C275(0.76); C378(0.93)  LDD1517  [18]
 LDCM0279  AC2 HEK-293T C275(0.97); C378(0.99)  LDD1518  [18]
 LDCM0280  AC20 HEK-293T C275(0.96); C378(0.99)  LDD1519  [18]
 LDCM0281  AC21 HEK-293T C275(1.01); C378(1.04)  LDD1520  [18]
 LDCM0282  AC22 HEK-293T C275(1.09); C378(0.98)  LDD1521  [18]
 LDCM0283  AC23 HEK-293T C275(1.04); C378(0.96)  LDD1522  [18]
 LDCM0284  AC24 HEK-293T C275(0.87); C378(0.98)  LDD1523  [18]
 LDCM0285  AC25 HEK-293T C275(1.04); C378(1.07)  LDD1524  [18]
 LDCM0286  AC26 HEK-293T C275(0.98); C378(0.99)  LDD1525  [18]
 LDCM0287  AC27 HEK-293T C275(0.70); C378(1.02)  LDD1526  [18]
 LDCM0288  AC28 HEK-293T C275(1.07); C378(1.03)  LDD1527  [18]
 LDCM0289  AC29 HEK-293T C275(1.31); C378(1.00)  LDD1528  [18]
 LDCM0290  AC3 HEK-293T C275(0.98); C378(1.00)  LDD1529  [18]
 LDCM0291  AC30 HEK-293T C275(1.11); C378(0.89)  LDD1530  [18]
 LDCM0292  AC31 HEK-293T C275(0.87); C378(0.94)  LDD1531  [18]
 LDCM0293  AC32 HEK-293T C275(0.96); C378(1.03)  LDD1532  [18]
 LDCM0294  AC33 HEK-293T C275(0.80); C378(1.02)  LDD1533  [18]
 LDCM0295  AC34 HEK-293T C275(1.03); C378(1.02)  LDD1534  [18]
 LDCM0296  AC35 HEK-293T C275(0.93); C378(0.98)  LDD1535  [18]
 LDCM0297  AC36 HEK-293T C275(0.98); C378(1.00)  LDD1536  [18]
 LDCM0298  AC37 HEK-293T C275(1.18); C378(0.97)  LDD1537  [18]
 LDCM0299  AC38 HEK-293T C275(0.89); C378(0.92)  LDD1538  [18]
 LDCM0300  AC39 HEK-293T C275(0.94); C378(1.06)  LDD1539  [18]
 LDCM0301  AC4 HEK-293T C275(1.01); C378(1.00)  LDD1540  [18]
 LDCM0302  AC40 HEK-293T C275(1.13); C378(0.97)  LDD1541  [18]
 LDCM0303  AC41 HEK-293T C275(0.89); C378(1.13)  LDD1542  [18]
 LDCM0304  AC42 HEK-293T C275(0.96); C378(1.06)  LDD1543  [18]
 LDCM0305  AC43 HEK-293T C275(0.88); C378(1.00)  LDD1544  [18]
 LDCM0306  AC44 HEK-293T C275(0.99); C378(1.04)  LDD1545  [18]
 LDCM0307  AC45 HEK-293T C275(0.89); C378(1.06)  LDD1546  [18]
 LDCM0308  AC46 HEK-293T C275(1.02); C378(0.94)  LDD1547  [18]
 LDCM0309  AC47 HEK-293T C275(0.98); C378(0.89)  LDD1548  [18]
 LDCM0310  AC48 HEK-293T C275(0.98); C378(1.01)  LDD1549  [18]
 LDCM0311  AC49 HEK-293T C275(0.69); C378(1.09)  LDD1550  [18]
 LDCM0312  AC5 HEK-293T C275(1.30); C378(1.02)  LDD1551  [18]
 LDCM0313  AC50 HEK-293T C275(0.97); C378(0.99)  LDD1552  [18]
 LDCM0314  AC51 HEK-293T C275(0.88); C378(1.03)  LDD1553  [18]
 LDCM0315  AC52 HEK-293T C275(0.97); C378(0.91)  LDD1554  [18]
 LDCM0316  AC53 HEK-293T C275(0.89); C378(1.02)  LDD1555  [18]
 LDCM0317  AC54 HEK-293T C275(0.99); C378(1.05)  LDD1556  [18]
 LDCM0318  AC55 HEK-293T C275(0.97); C378(0.92)  LDD1557  [18]
 LDCM0319  AC56 HEK-293T C275(1.04); C378(0.95)  LDD1558  [18]
 LDCM0320  AC57 HEK-293T C275(0.82); C378(1.13)  LDD1559  [18]
 LDCM0321  AC58 HEK-293T C275(1.07); C378(0.99)  LDD1560  [18]
 LDCM0322  AC59 HEK-293T C275(1.00); C378(1.08)  LDD1561  [18]
 LDCM0323  AC6 HEK-293T C275(0.96); C378(1.04)  LDD1562  [18]
 LDCM0324  AC60 HEK-293T C275(0.96); C378(1.02)  LDD1563  [18]
 LDCM0325  AC61 HEK-293T C275(1.02); C378(1.07)  LDD1564  [18]
 LDCM0326  AC62 HEK-293T C275(1.01); C378(1.00)  LDD1565  [18]
 LDCM0327  AC63 HEK-293T C275(0.90); C378(0.96)  LDD1566  [18]
 LDCM0328  AC64 HEK-293T C275(1.08); C378(0.98)  LDD1567  [18]
 LDCM0334  AC7 HEK-293T C275(0.89); C378(0.94)  LDD1568  [18]
 LDCM0345  AC8 HEK-293T C275(0.93); C378(0.99)  LDD1569  [18]
 LDCM0248  AKOS034007472 HEK-293T C275(0.92); C378(0.96)  LDD1511  [18]
 LDCM0356  AKOS034007680 HEK-293T C275(0.82); C378(1.08)  LDD1570  [18]
 LDCM0275  AKOS034007705 HEK-293T C275(0.98); C378(1.00)  LDD1514  [18]
 LDCM0156  Aniline NCI-H1299 11.35  LDD0403  [1]
 LDCM0108  Chloroacetamide HeLa N.A.  LDD0222  [8]
 LDCM0632  CL-Sc Hep-G2 C378(0.89)  LDD2227  [16]
 LDCM0367  CL1 HEK-293T C275(0.93); C378(1.18)  LDD1571  [18]
 LDCM0368  CL10 HEK-293T C275(0.76); C378(1.46)  LDD1572  [18]
 LDCM0369  CL100 HEK-293T C275(1.16); C378(0.91)  LDD1573  [18]
 LDCM0370  CL101 HEK-293T C275(0.95); C378(1.03)  LDD1574  [18]
 LDCM0371  CL102 HEK-293T C275(0.90); C378(1.05)  LDD1575  [18]
 LDCM0372  CL103 HEK-293T C275(0.94); C378(0.98); C806(1.12)  LDD1576  [18]
 LDCM0373  CL104 HEK-293T C275(1.14); C378(0.94)  LDD1577  [18]
 LDCM0374  CL105 HEK-293T C275(1.01); C378(0.98)  LDD1578  [18]
 LDCM0375  CL106 HEK-293T C275(0.90); C378(0.95)  LDD1579  [18]
 LDCM0376  CL107 HEK-293T C275(1.09); C378(0.98); C806(0.97)  LDD1580  [18]
 LDCM0377  CL108 HEK-293T C275(1.04); C378(1.12)  LDD1581  [18]
 LDCM0378  CL109 HEK-293T C275(1.04); C378(0.92)  LDD1582  [18]
 LDCM0379  CL11 HEK-293T C275(0.84); C378(1.07)  LDD1583  [18]
 LDCM0380  CL110 HEK-293T C275(0.97); C378(1.01)  LDD1584  [18]
 LDCM0381  CL111 HEK-293T C275(0.96); C378(1.14); C806(1.04)  LDD1585  [18]
 LDCM0382  CL112 HEK-293T C275(1.21); C378(1.30)  LDD1586  [18]
 LDCM0383  CL113 HEK-293T C275(0.92); C378(0.92)  LDD1587  [18]
 LDCM0384  CL114 HEK-293T C275(0.89); C378(0.89)  LDD1588  [18]
 LDCM0385  CL115 HEK-293T C275(0.84); C378(1.16); C806(1.13)  LDD1589  [18]
 LDCM0386  CL116 HEK-293T C275(1.03); C378(0.96)  LDD1590  [18]
 LDCM0387  CL117 HEK-293T C275(0.95); C378(0.93)  LDD1591  [18]
 LDCM0388  CL118 HEK-293T C275(0.94); C378(0.89)  LDD1592  [18]
 LDCM0389  CL119 HEK-293T C275(0.96); C378(0.86); C806(1.02)  LDD1593  [18]
 LDCM0390  CL12 HEK-293T C275(0.87); C378(1.05)  LDD1594  [18]
 LDCM0391  CL120 HEK-293T C275(1.28); C378(0.95)  LDD1595  [18]
 LDCM0392  CL121 HEK-293T C275(0.97); C378(1.02)  LDD1596  [18]
 LDCM0393  CL122 HEK-293T C275(1.02); C378(0.90)  LDD1597  [18]
 LDCM0394  CL123 HEK-293T C275(0.88); C378(1.32); C806(1.11)  LDD1598  [18]
 LDCM0395  CL124 HEK-293T C275(1.03); C378(0.95)  LDD1599  [18]
 LDCM0396  CL125 HEK-293T C275(0.98); C378(1.05)  LDD1600  [18]
 LDCM0397  CL126 HEK-293T C275(0.99); C378(1.11)  LDD1601  [18]
 LDCM0398  CL127 HEK-293T C275(1.13); C378(0.96); C806(1.23)  LDD1602  [18]
 LDCM0399  CL128 HEK-293T C275(1.03); C378(0.93)  LDD1603  [18]
 LDCM0400  CL13 HEK-293T C275(0.86); C378(1.11)  LDD1604  [18]
 LDCM0401  CL14 HEK-293T C275(1.01); C378(1.11)  LDD1605  [18]
 LDCM0402  CL15 HEK-293T C275(0.84); C378(0.85); C806(1.11)  LDD1606  [18]
 LDCM0403  CL16 HEK-293T C275(1.19); C378(0.98)  LDD1607  [18]
 LDCM0404  CL17 HEK-293T C275(0.73); C378(1.10)  LDD1608  [18]
 LDCM0405  CL18 HEK-293T C275(0.98); C378(1.03)  LDD1609  [18]
 LDCM0406  CL19 HEK-293T C275(1.04); C378(0.99)  LDD1610  [18]
 LDCM0407  CL2 HEK-293T C275(0.98); C378(1.31)  LDD1611  [18]
 LDCM0408  CL20 HEK-293T C275(0.97); C378(1.10)  LDD1612  [18]
 LDCM0409  CL21 HEK-293T C275(0.85); C378(1.02)  LDD1613  [18]
 LDCM0410  CL22 HEK-293T C275(1.01); C378(1.25)  LDD1614  [18]
 LDCM0411  CL23 HEK-293T C275(1.06); C378(1.00)  LDD1615  [18]
 LDCM0412  CL24 HEK-293T C275(0.90); C378(1.08)  LDD1616  [18]
 LDCM0413  CL25 HEK-293T C275(0.92); C378(0.97)  LDD1617  [18]
 LDCM0414  CL26 HEK-293T C275(0.99); C378(0.99)  LDD1618  [18]
 LDCM0415  CL27 HEK-293T C275(0.89); C378(0.93); C806(1.00)  LDD1619  [18]
 LDCM0416  CL28 HEK-293T C275(1.28); C378(0.99)  LDD1620  [18]
 LDCM0417  CL29 HEK-293T C275(0.82); C378(1.05)  LDD1621  [18]
 LDCM0418  CL3 HEK-293T C275(1.00); C378(0.91); C806(1.10)  LDD1622  [18]
 LDCM0419  CL30 HEK-293T C275(0.95); C378(1.05)  LDD1623  [18]
 LDCM0420  CL31 HEK-293T C275(0.81); C378(1.39)  LDD1624  [18]
 LDCM0421  CL32 HEK-293T C275(1.07); C378(1.08)  LDD1625  [18]
 LDCM0422  CL33 HEK-293T C275(0.93); C378(0.86)  LDD1626  [18]
 LDCM0423  CL34 HEK-293T C275(0.96); C378(1.03)  LDD1627  [18]
 LDCM0424  CL35 HEK-293T C275(1.05); C378(1.12)  LDD1628  [18]
 LDCM0425  CL36 HEK-293T C275(1.03); C378(0.99)  LDD1629  [18]
 LDCM0426  CL37 HEK-293T C275(0.95); C378(1.04)  LDD1630  [18]
 LDCM0428  CL39 HEK-293T C275(1.01); C378(1.56); C806(1.08)  LDD1632  [18]
 LDCM0429  CL4 HEK-293T C275(0.87); C378(0.99)  LDD1633  [18]
 LDCM0430  CL40 HEK-293T C275(1.15); C378(1.17)  LDD1634  [18]
 LDCM0431  CL41 HEK-293T C275(0.87); C378(1.15)  LDD1635  [18]
 LDCM0432  CL42 HEK-293T C275(0.98); C378(1.07)  LDD1636  [18]
 LDCM0433  CL43 HEK-293T C275(0.93); C378(1.03)  LDD1637  [18]
 LDCM0434  CL44 HEK-293T C275(0.94); C378(1.00)  LDD1638  [18]
 LDCM0435  CL45 HEK-293T C275(0.92); C378(1.47)  LDD1639  [18]
 LDCM0436  CL46 HEK-293T C275(1.07); C378(2.46)  LDD1640  [18]
 LDCM0437  CL47 HEK-293T C275(0.99); C378(1.17)  LDD1641  [18]
 LDCM0438  CL48 HEK-293T C275(0.94); C378(1.06)  LDD1642  [18]
 LDCM0439  CL49 HEK-293T C275(1.08); C378(0.91)  LDD1643  [18]
 LDCM0440  CL5 HEK-293T C275(0.79); C378(1.18)  LDD1644  [18]
 LDCM0441  CL50 HEK-293T C275(0.98); C378(0.91)  LDD1645  [18]
 LDCM0443  CL52 HEK-293T C275(1.09); C378(1.01)  LDD1646  [18]
 LDCM0444  CL53 HEK-293T C275(0.81); C378(1.05)  LDD1647  [18]
 LDCM0445  CL54 HEK-293T C275(0.93); C378(1.78)  LDD1648  [18]
 LDCM0446  CL55 HEK-293T C275(0.98); C378(1.06)  LDD1649  [18]
 LDCM0447  CL56 HEK-293T C275(1.01); C378(1.60)  LDD1650  [18]
 LDCM0448  CL57 HEK-293T C275(0.80); C378(1.68)  LDD1651  [18]
 LDCM0449  CL58 HEK-293T C275(0.94); C378(1.02)  LDD1652  [18]
 LDCM0450  CL59 HEK-293T C275(1.03); C378(1.04)  LDD1653  [18]
 LDCM0451  CL6 HEK-293T C275(0.87); C378(0.94)  LDD1654  [18]
 LDCM0452  CL60 HEK-293T C275(0.93); C378(1.21)  LDD1655  [18]
 LDCM0453  CL61 HEK-293T C275(0.98); C378(0.98)  LDD1656  [18]
 LDCM0454  CL62 HEK-293T C275(0.94); C378(0.99)  LDD1657  [18]
 LDCM0455  CL63 HEK-293T C275(0.95); C378(0.98); C806(1.09)  LDD1658  [18]
 LDCM0456  CL64 HEK-293T C275(0.92); C378(0.92)  LDD1659  [18]
 LDCM0457  CL65 HEK-293T C275(0.79); C378(1.15)  LDD1660  [18]
 LDCM0458  CL66 HEK-293T C275(0.95); C378(1.28)  LDD1661  [18]
 LDCM0459  CL67 HEK-293T C275(1.00); C378(1.01)  LDD1662  [18]
 LDCM0460  CL68 HEK-293T C275(0.95); C378(1.35)  LDD1663  [18]
 LDCM0461  CL69 HEK-293T C275(0.96); C378(1.49)  LDD1664  [18]
 LDCM0462  CL7 HEK-293T C275(0.96); C378(1.05)  LDD1665  [18]
 LDCM0463  CL70 HEK-293T C275(1.00); C378(1.04)  LDD1666  [18]
 LDCM0464  CL71 HEK-293T C275(1.02); C378(1.00)  LDD1667  [18]
 LDCM0465  CL72 HEK-293T C275(1.08); C378(1.00)  LDD1668  [18]
 LDCM0466  CL73 HEK-293T C275(0.98); C378(1.00)  LDD1669  [18]
 LDCM0467  CL74 HEK-293T C275(1.09); C378(1.00)  LDD1670  [18]
 LDCM0469  CL76 HEK-293T C275(1.02); C378(1.00)  LDD1672  [18]
 LDCM0470  CL77 HEK-293T C275(0.65); C378(1.31)  LDD1673  [18]
 LDCM0471  CL78 HEK-293T C275(0.97); C378(0.99)  LDD1674  [18]
 LDCM0472  CL79 HEK-293T C275(0.97); C378(1.02)  LDD1675  [18]
 LDCM0473  CL8 HEK-293T C275(0.63); C378(1.08)  LDD1676  [18]
 LDCM0474  CL80 HEK-293T C275(1.06); C378(1.03)  LDD1677  [18]
 LDCM0475  CL81 HEK-293T C275(0.95); C378(1.05)  LDD1678  [18]
 LDCM0476  CL82 HEK-293T C275(1.00); C378(0.96)  LDD1679  [18]
 LDCM0477  CL83 HEK-293T C275(0.96); C378(0.95)  LDD1680  [18]
 LDCM0478  CL84 HEK-293T C275(1.02); C378(0.97)  LDD1681  [18]
 LDCM0479  CL85 HEK-293T C275(0.96); C378(1.00)  LDD1682  [18]
 LDCM0480  CL86 HEK-293T C275(1.07); C378(1.02)  LDD1683  [18]
 LDCM0481  CL87 HEK-293T C275(1.04); C378(1.12); C806(1.17)  LDD1684  [18]
 LDCM0482  CL88 HEK-293T C275(1.14); C378(0.93)  LDD1685  [18]
 LDCM0483  CL89 HEK-293T C275(0.79); C378(1.14)  LDD1686  [18]
 LDCM0484  CL9 HEK-293T C275(0.84); C378(1.05)  LDD1687  [18]
 LDCM0485  CL90 HEK-293T C275(0.82); C378(0.91)  LDD1688  [18]
 LDCM0486  CL91 HEK-293T C275(1.02); C378(1.05)  LDD1689  [18]
 LDCM0487  CL92 HEK-293T C275(0.92); C378(1.26)  LDD1690  [18]
 LDCM0488  CL93 HEK-293T C275(0.92); C378(0.95)  LDD1691  [18]
 LDCM0489  CL94 HEK-293T C275(0.98); C378(1.36)  LDD1692  [18]
 LDCM0490  CL95 HEK-293T C275(0.77); C378(0.88)  LDD1693  [18]
 LDCM0491  CL96 HEK-293T C275(0.94); C378(1.12)  LDD1694  [18]
 LDCM0492  CL97 HEK-293T C275(0.91); C378(0.97)  LDD1695  [18]
 LDCM0493  CL98 HEK-293T C275(0.97); C378(1.06)  LDD1696  [18]
 LDCM0494  CL99 HEK-293T C275(0.88); C378(1.80); C806(1.04)  LDD1697  [18]
 LDCM0495  E2913 HEK-293T C275(0.96); C378(0.74); C806(1.12)  LDD1698  [18]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C378(0.90)  LDD1702  [5]
 LDCM0468  Fragment33 HEK-293T C275(1.02); C378(1.96); C806(1.02)  LDD1671  [18]
 LDCM0427  Fragment51 HEK-293T C275(1.08); C378(0.95)  LDD1631  [18]
 LDCM0116  HHS-0101 DM93 Y760(1.42)  LDD0264  [6]
 LDCM0117  HHS-0201 DM93 Y760(2.21)  LDD0265  [6]
 LDCM0118  HHS-0301 DM93 Y760(1.38)  LDD0266  [6]
 LDCM0119  HHS-0401 DM93 Y760(1.58)  LDD0267  [6]
 LDCM0120  HHS-0701 DM93 Y760(1.92)  LDD0268  [6]
 LDCM0107  IAA HeLa N.A.  LDD0221  [8]
 LDCM0022  KB02 HEK-293T C378(0.98)  LDD1492  [18]
 LDCM0023  KB03 HEK-293T C378(0.98)  LDD1497  [18]
 LDCM0024  KB05 HMCB C378(3.11)  LDD3312  [4]
 LDCM0109  NEM HeLa N.A.  LDD0223  [8]
 LDCM0499  Nucleophilic fragment 12b MDA-MB-231 C378(0.86)  LDD2092  [5]
 LDCM0521  Nucleophilic fragment 23b MDA-MB-231 C378(0.70)  LDD2114  [5]
 LDCM0530  Nucleophilic fragment 28a MDA-MB-231 C378(1.12)  LDD2123  [5]
 LDCM0542  Nucleophilic fragment 37 MDA-MB-231 C275(2.28); C378(0.95)  LDD2135  [5]
 LDCM0559  Nucleophilic fragment 9b MDA-MB-231 C378(2.70)  LDD2153  [5]
 LDCM0131  RA190 MM1.R C378(1.10)  LDD0304  [19]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 6 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Guanylate cyclase soluble subunit alpha-2 (GUCY1A2) Adenylyl cyclase class-4/guanylyl cyclase family P33402
Mitogen-activated protein kinase 12 (MAPK12) CMGC Ser/Thr protein kinase family P53778
Dual specificity mitogen-activated protein kinase kinase 2 (MAP2K2) STE Ser/Thr protein kinase family P36507
Kinesin-like protein KIF13B (KIF13B) Kinesin family Q9NQT8
Disintegrin and metalloproteinase domain-containing protein 17 (ADAM17) . P78536
RalA-binding protein 1 (RALBP1) . Q15311
Transporter and channel
Click To Hide/Show 6 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Anoctamin-2 (ANO2) Anoctamin family Q9NQ90
Anoctamin-9 (ANO9) Anoctamin family A1A5B4
Calcium homeostasis modulator protein 3 (CALHM3) CALHM family Q86XJ0
Glutamate receptor ionotropic, NMDA 2B (GRIN2B) Glutamate-gated ion channel family Q13224
Glutamate receptor ionotropic, NMDA 2C (GRIN2C) Glutamate-gated ion channel family Q14957
Monocarboxylate transporter 4 (SLC16A3) Monocarboxylate porter (TC 2.A.1.13) family O15427
GPCR
Click To Hide/Show 3 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Cysteinyl leukotriene receptor 2 (CYSLTR2) G-protein coupled receptor 1 family Q9NS75
Corticotropin-releasing factor receptor 1 (CRHR1) G-protein coupled receptor 2 family P34998
Adhesion G protein-coupled receptor A2 (ADGRA2) G-protein coupled receptor 2 family Q96PE1
Immunoglobulin
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Antigen-presenting glycoprotein CD1d (CD1D) . P15813
Other
Click To Hide/Show 13 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Adenomatous polyposis coli protein (APC) Adenomatous polyposis coli (APC) family P25054
Catenin delta-2 (CTNND2) Beta-catenin family Q9UQB3
Plakophilin-4 (PKP4) Beta-catenin family Q99569
Protein FAM163B (FAM163B) FAM163 family P0C2L3
HEAT repeat-containing protein 5B (HEATR5B) HEATR5 family Q9P2D3
Proline-rich protein 5 (PRR5) PROTOR family P85299
Protein TANC1 (TANC1) TANC family Q9C0D5
Vang-like protein 2 (VANGL2) Vang family Q9ULK5
Ecotropic viral integration site 5 protein homolog (EVI5) . O60447
F-box/WD repeat-containing protein 1A (BTRC) . Q9Y297
FERM and PDZ domain-containing protein 4 (FRMPD4) . Q14CM0
Neuroepithelial cell-transforming gene 1 protein (NET1) . Q7Z628
Rho guanine nucleotide exchange factor 16 (ARHGEF16) . Q5VV41

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
3 An Azo Coupling-Based Chemoproteomic Approach to Systematically Profile the Tyrosine Reactivity in the Human Proteome. Anal Chem. 2021 Jul 27;93(29):10334-10342. doi: 10.1021/acs.analchem.1c01935. Epub 2021 Jul 12.
4 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
5 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
6 Discovery of a Cell-Active SuTEx Ligand of Prostaglandin Reductase 2. Chembiochem. 2021 Jun 15;22(12):2134-2139. doi: 10.1002/cbic.202000879. Epub 2021 Apr 29.
7 Global targeting of functional tyrosines using sulfur-triazole exchange chemistry. Nat Chem Biol. 2020 Feb;16(2):150-159. doi: 10.1038/s41589-019-0404-5. Epub 2019 Nov 25.
8 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
9 Targeted Proteomic Approaches for Proteome-Wide Characterizations of the AMP-Binding Capacities of Kinases. J Proteome Res. 2022 Aug 5;21(8):2063-2070. doi: 10.1021/acs.jproteome.2c00225. Epub 2022 Jul 12.
10 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
11 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
12 Multiplexed CuAAC Suzuki-Miyaura Labeling for Tandem Activity-Based Chemoproteomic Profiling. Anal Chem. 2021 Feb 2;93(4):2610-2618. doi: 10.1021/acs.analchem.0c04726. Epub 2021 Jan 20.
Mass spectrometry data entry: PXD022279
13 Solid Phase Synthesis of Fluorosulfate Containing Macrocycles for Chemoproteomic Workflows. bioRxiv [Preprint]. 2023 Feb 18:2023.02.17.529022. doi: 10.1101/2023.02.17.529022.
Mass spectrometry data entry: PXD039931
14 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
15 DFT-Guided Discovery of Ethynyl-Triazolyl-Phosphinates as Modular Electrophiles for Chemoselective Cysteine Bioconjugation and Profiling. Angew Chem Int Ed Engl. 2022 Oct 10;61(41):e202205348. doi: 10.1002/anie.202205348. Epub 2022 Aug 22.
Mass spectrometry data entry: PXD033004
16 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
17 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587
18 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
19 Physical and Functional Analysis of the Putative Rpn13 Inhibitor RA190. Cell Chem Biol. 2020 Nov 19;27(11):1371-1382.e6. doi: 10.1016/j.chembiol.2020.08.007. Epub 2020 Aug 27.