Details of the Target

General Information of Target

Target ID LDTP05399
Target Name Centromere protein C (CENPC)
Gene Name CENPC
Gene ID 1060
Synonyms
CENPC1; ICEN7; Centromere protein C; CENP-C; Centromere autoantigen C; Centromere protein C 1; CENP-C 1; Interphase centromere complex protein 7
3D Structure
Download
2D Sequence (FASTA)
Download
3D Structure (PDB)
Download
Sequence
MAASGLDHLKNGYRRRFCRPSRARDINTEQGQNVLEILQDCFEEKSLANDFSTNSTKSVP
NSTRKIKDTCIQSPSKECQKSHPKSVPVSSKKKEASLQFVVEPSEATNRSVQAHEVHQKI
LATDVSSKNTPDSKKISSRNINDHHSEADEEFYLSVGSPSVLLDAKTSVSQNVIPSSAQK
RETYTFENSVNMLPSSTEVSVKTKKRLNFDDKVMLKKIEIDNKVSDEEDKTSEGQERKPS
GSSQNRIRDSEYEIQRQAKKSFSTLFLETVKRKSESSPIVRHAATAPPHSCPPDDTKLIE
DEFIIDESDQSFASRSWITIPRKAGSLKQRTISPAESTALLQGRKSREKHHNILPKTLAN
DKHSHKPHPVETSQPSDKTVLDTSYALIGETVNNYRSTKYEMYSKNAEKPSRSKRTIKQK
QRRKFMAKPAEEQLDVGQSKDENIHTSHITQDEFQRNSDRNMEEHEEMGNDCVSKKQMPP
VGSKKSSTRKDKEESKKKRFSSESKNKLVPEEVTSTVTKSRRISRRPSDWWVVKSEESPV
YSNSSVRNELPMHHNSSRKSTKKTNQSSKNIRKKTIPLKRQKTATKGNQRVQKFLNAEGS
GGIVGHDEISRCSLSEPLESDEADLAKKKNLDCSRSTRSSKNEDNIMTAQNVPLKPQTSG
YTCNIPTESNLDSGEHKTSVLEESGPSRLNNNYLMSGKNDVDDEEVHGSSDDSKQSKVIP
KNRIHHKLVLPSNTPNVRRTKRTRLKPLEYWRGERIDYQGRPSGGFVISGVLSPDTISSK
RKAKENIGKVNKKSNKKRICLDNDERKTNLMVNLGIPLGDPLQPTRVKDPETREIILMDL
VRPQDTYQFFVKHGELKVYKTLDTPFFSTGKLILGPQEEKGKQHVGQDILVFYVNFGDLL
CTLHETPYILSTGDSFYVPSGNYYNIKNLRNEESVLLFTQIKR
Target Bioclass
Other
Family
CENP-C/MIF2 family
Subcellular location
Nucleus
Function
Component of the CENPA-NAC (nucleosome-associated) complex, a complex that plays a central role in assembly of kinetochore proteins, mitotic progression and chromosome segregation. The CENPA-NAC complex recruits the CENPA-CAD (nucleosome distal) complex and may be involved in incorporation of newly synthesized CENPA into centromeres. CENPC recruits DNA methylation and DNMT3B to both centromeric and pericentromeric satellite repeats and regulates the histone code in these regions.
Uniprot ID
Q03188
Ensemble ID
ENST00000273853.11
HGNC ID
HGNC:1854

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
A431 Substitution: p.T203K DBIA    Probe Info 
C4II SNV: p.S778L DBIA    Probe Info 
IGR1 SNV: p.T319I .
IGROV1 Deletion: p.S261VfsTer7; p.S868LfsTer5 .
JM1 Deletion: p.S486VfsTer28
SNV: .		 DBIA    Probe Info 
JURKAT SNV: p.S277N .
LNCaP clone FGC Deletion: p.S868LfsTer5 DBIA    Probe Info 
MFE319 Insertion: p.V851CfsTer2 DBIA    Probe Info 
NCIH358 SNV: p.E151K DBIA    Probe Info 
TE4 SNV: p.H145Y DBIA    Probe Info 
TF1 SNV: p.S568A .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 13 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
STPyne
 Probe Info  		K860(0.93)  LDD0277  [1]
Probe 1
 Probe Info  		Y252(16.03)  LDD3495  [2]
AHL-Pu-1
 Probe Info  		C663(2.53); C472(2.06)  LDD0170  [3]
DBIA
 Probe Info  		C800(1.01)  LDD0547  [4]
4-Iodoacetamidophenylacetylene
 Probe Info  		N.A.  LDD0038  [5]
IA-alkyne
 Probe Info  		N.A.  LDD0165  [6]
Lodoacetamide azide
 Probe Info  		N.A.  LDD0037  [5]
IPM
 Probe Info  		N.A.  LDD0025  [7]
NAIA_4
 Probe Info  		N.A.  LDD2226  [8]
NAIA_5
 Probe Info  		N.A.  LDD2224  [8]
NHS
 Probe Info  		N.A.  LDD0010  [9]
VSF
 Probe Info  		N.A.  LDD0007  [9]
Phosphinate-6
 Probe Info  		C18(0.00); C472(0.00); C291(0.00)  LDD0018  [10]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0025  4SU-RNA DM93 C663(2.53); C472(2.06)  LDD0170  [3]
 LDCM0026  4SU-RNA+native RNA DM93 C663(3.70); C472(4.71)  LDD0171  [3]
 LDCM0214  AC1 HEK-293T C800(0.90); C291(1.04)  LDD1507  [11]
 LDCM0215  AC10 HEK-293T C800(0.96); C291(1.04)  LDD1508  [11]
 LDCM0226  AC11 HEK-293T C472(1.10); C800(1.02); C291(0.97)  LDD1509  [11]
 LDCM0230  AC113 HCT 116 C800(1.01)  LDD0547  [4]
 LDCM0231  AC114 HCT 116 C800(1.11)  LDD0548  [4]
 LDCM0232  AC115 HCT 116 C800(1.07)  LDD0549  [4]
 LDCM0233  AC116 HCT 116 C800(1.29)  LDD0550  [4]
 LDCM0234  AC117 HCT 116 C800(1.40)  LDD0551  [4]
 LDCM0235  AC118 HCT 116 C800(1.00)  LDD0552  [4]
 LDCM0236  AC119 HCT 116 C800(1.54)  LDD0553  [4]
 LDCM0237  AC12 HEK-293T C472(1.02); C800(1.04); C291(1.06); C612(1.03)  LDD1510  [11]
 LDCM0238  AC120 HCT 116 C800(1.12)  LDD0555  [4]
 LDCM0239  AC121 HCT 116 C800(0.87)  LDD0556  [4]
 LDCM0240  AC122 HCT 116 C800(1.04)  LDD0557  [4]
 LDCM0241  AC123 HCT 116 C800(1.03)  LDD0558  [4]
 LDCM0242  AC124 HCT 116 C800(1.19)  LDD0559  [4]
 LDCM0243  AC125 HCT 116 C800(0.92)  LDD0560  [4]
 LDCM0244  AC126 HCT 116 C800(1.20)  LDD0561  [4]
 LDCM0245  AC127 HCT 116 C800(0.89)  LDD0562  [4]
 LDCM0259  AC14 HEK-293T C472(1.07); C800(1.07); C291(0.98); C41(1.19)  LDD1512  [11]
 LDCM0263  AC143 HEK-293T C800(1.11)  LDD0861  [4]
 LDCM0264  AC144 HEK-293T C800(1.00)  LDD0862  [4]
 LDCM0265  AC145 HEK-293T C800(0.80)  LDD0863  [4]
 LDCM0266  AC146 HEK-293T C800(1.70)  LDD0864  [4]
 LDCM0267  AC147 HEK-293T C800(1.41)  LDD0865  [4]
 LDCM0268  AC148 HEK-293T C800(0.74)  LDD0866  [4]
 LDCM0269  AC149 HEK-293T C800(0.89)  LDD0867  [4]
 LDCM0270  AC15 HEK-293T C472(0.98); C800(0.98); C291(1.18)  LDD1513  [11]
 LDCM0271  AC150 HEK-293T C800(0.89)  LDD0869  [4]
 LDCM0272  AC151 HEK-293T C800(0.78)  LDD0870  [4]
 LDCM0273  AC152 HEK-293T C800(0.85)  LDD0871  [4]
 LDCM0274  AC153 HEK-293T C800(1.12)  LDD0872  [4]
 LDCM0621  AC154 HEK-293T C800(1.04)  LDD2162  [4]
 LDCM0622  AC155 HEK-293T C800(0.92)  LDD2163  [4]
 LDCM0623  AC156 HEK-293T C800(0.92)  LDD2164  [4]
 LDCM0624  AC157 HEK-293T C800(1.21)  LDD2165  [4]
 LDCM0276  AC17 HCT 116 C800(1.00)  LDD0593  [4]
 LDCM0277  AC18 HCT 116 C800(0.82)  LDD0594  [4]
 LDCM0278  AC19 HCT 116 C800(0.90)  LDD0595  [4]
 LDCM0279  AC2 HEK-293T C800(0.92); C291(1.13)  LDD1518  [11]
 LDCM0280  AC20 HCT 116 C800(1.06)  LDD0597  [4]
 LDCM0281  AC21 HCT 116 C800(0.76)  LDD0598  [4]
 LDCM0282  AC22 HCT 116 C800(1.00)  LDD0599  [4]
 LDCM0283  AC23 HCT 116 C800(0.87)  LDD0600  [4]
 LDCM0284  AC24 HCT 116 C800(1.05)  LDD0601  [4]
 LDCM0285  AC25 HEK-293T C800(1.40)  LDD0883  [4]
 LDCM0286  AC26 HEK-293T C800(1.15)  LDD0884  [4]
 LDCM0287  AC27 HEK-293T C800(1.14)  LDD0885  [4]
 LDCM0288  AC28 HEK-293T C800(1.85)  LDD0886  [4]
 LDCM0289  AC29 HEK-293T C800(1.50)  LDD0887  [4]
 LDCM0290  AC3 HEK-293T C472(1.10); C800(0.97); C291(0.89)  LDD1529  [11]
 LDCM0291  AC30 HEK-293T C800(1.35)  LDD0889  [4]
 LDCM0292  AC31 HEK-293T C800(1.21)  LDD0890  [4]
 LDCM0293  AC32 HEK-293T C800(1.43)  LDD0891  [4]
 LDCM0294  AC33 HEK-293T C800(1.33)  LDD0892  [4]
 LDCM0295  AC34 HEK-293T C800(1.39)  LDD0893  [4]
 LDCM0296  AC35 HCT 116 C800(0.71)  LDD0613  [4]
 LDCM0297  AC36 HCT 116 C800(0.67)  LDD0614  [4]
 LDCM0298  AC37 HCT 116 C800(0.92)  LDD0615  [4]
 LDCM0299  AC38 HCT 116 C800(0.80)  LDD0616  [4]
 LDCM0300  AC39 HCT 116 C800(0.99)  LDD0617  [4]
 LDCM0301  AC4 HEK-293T C472(1.03); C800(0.91); C291(1.07); C612(0.95)  LDD1540  [11]
 LDCM0302  AC40 HCT 116 C800(1.02)  LDD0619  [4]
 LDCM0303  AC41 HCT 116 C800(0.72)  LDD0620  [4]
 LDCM0304  AC42 HCT 116 C800(1.12)  LDD0621  [4]
 LDCM0305  AC43 HCT 116 C800(1.09)  LDD0622  [4]
 LDCM0306  AC44 HCT 116 C800(1.24)  LDD0623  [4]
 LDCM0307  AC45 HCT 116 C800(0.74)  LDD0624  [4]
 LDCM0308  AC46 HCT 116 C800(1.02)  LDD0625  [4]
 LDCM0309  AC47 HCT 116 C800(1.20)  LDD0626  [4]
 LDCM0310  AC48 HCT 116 C800(1.10)  LDD0627  [4]
 LDCM0311  AC49 HCT 116 C800(1.16)  LDD0628  [4]
 LDCM0312  AC5 HEK-293T C472(0.92); C800(0.96)  LDD1551  [11]
 LDCM0313  AC50 HCT 116 C800(1.34)  LDD0630  [4]
 LDCM0314  AC51 HCT 116 C800(0.99)  LDD0631  [4]
 LDCM0315  AC52 HCT 116 C800(0.91)  LDD0632  [4]
 LDCM0316  AC53 HCT 116 C800(2.02)  LDD0633  [4]
 LDCM0317  AC54 HCT 116 C800(1.06)  LDD0634  [4]
 LDCM0318  AC55 HCT 116 C800(1.50)  LDD0635  [4]
 LDCM0319  AC56 HCT 116 C800(1.55)  LDD0636  [4]
 LDCM0320  AC57 HEK-293T C800(0.99); C291(1.06)  LDD1559  [11]
 LDCM0321  AC58 HEK-293T C800(1.02); C291(1.06)  LDD1560  [11]
 LDCM0322  AC59 HEK-293T C472(1.06); C800(0.95); C291(0.95)  LDD1561  [11]
 LDCM0323  AC6 HEK-293T C472(0.90); C800(1.00); C291(0.98); C41(1.32)  LDD1562  [11]
 LDCM0324  AC60 HEK-293T C472(1.06); C800(1.10); C291(1.07); C612(1.04)  LDD1563  [11]
 LDCM0325  AC61 HEK-293T C472(0.94); C800(1.11)  LDD1564  [11]
 LDCM0326  AC62 HEK-293T C472(1.08); C800(1.10); C291(0.93); C41(1.02)  LDD1565  [11]
 LDCM0327  AC63 HEK-293T C472(1.04); C800(0.99); C291(1.05)  LDD1566  [11]
 LDCM0328  AC64 HEK-293T C472(0.93); C800(0.89); C291(0.96); C70(1.04)  LDD1567  [11]
 LDCM0332  AC68 HCT 116 C800(0.81)  LDD0649  [4]
 LDCM0333  AC69 HCT 116 C800(0.76)  LDD0650  [4]
 LDCM0334  AC7 HEK-293T C472(1.02); C800(1.00); C291(1.21)  LDD1568  [11]
 LDCM0335  AC70 HCT 116 C800(0.95)  LDD0652  [4]
 LDCM0336  AC71 HCT 116 C800(0.90)  LDD0653  [4]
 LDCM0337  AC72 HCT 116 C800(1.08)  LDD0654  [4]
 LDCM0338  AC73 HCT 116 C800(1.20)  LDD0655  [4]
 LDCM0339  AC74 HCT 116 C800(1.05)  LDD0656  [4]
 LDCM0340  AC75 HCT 116 C800(0.87)  LDD0657  [4]
 LDCM0341  AC76 HCT 116 C800(0.87)  LDD0658  [4]
 LDCM0342  AC77 HCT 116 C800(0.83)  LDD0659  [4]
 LDCM0343  AC78 HCT 116 C800(0.81)  LDD0660  [4]
 LDCM0344  AC79 HCT 116 C800(0.83)  LDD0661  [4]
 LDCM0345  AC8 HEK-293T C472(1.08); C800(0.96); C291(1.05); C70(1.08)  LDD1569  [11]
 LDCM0346  AC80 HCT 116 C800(1.09)  LDD0663  [4]
 LDCM0347  AC81 HCT 116 C800(0.73)  LDD0664  [4]
 LDCM0348  AC82 HCT 116 C800(1.08)  LDD0665  [4]
 LDCM0349  AC83 HEK-293T C800(1.40)  LDD0947  [4]
 LDCM0350  AC84 HEK-293T C800(1.32)  LDD0948  [4]
 LDCM0351  AC85 HEK-293T C800(1.22)  LDD0949  [4]
 LDCM0352  AC86 HEK-293T C800(1.72)  LDD0950  [4]
 LDCM0353  AC87 HEK-293T C800(1.48)  LDD0951  [4]
 LDCM0354  AC88 HEK-293T C800(1.01)  LDD0952  [4]
 LDCM0355  AC89 HEK-293T C800(1.48)  LDD0953  [4]
 LDCM0357  AC90 HEK-293T C800(1.35)  LDD0955  [4]
 LDCM0358  AC91 HEK-293T C800(1.05)  LDD0956  [4]
 LDCM0359  AC92 HEK-293T C800(0.90)  LDD0957  [4]
 LDCM0360  AC93 HEK-293T C800(1.37)  LDD0958  [4]
 LDCM0361  AC94 HEK-293T C800(1.44)  LDD0959  [4]
 LDCM0362  AC95 HEK-293T C800(1.27)  LDD0960  [4]
 LDCM0363  AC96 HEK-293T C800(1.20)  LDD0961  [4]
 LDCM0364  AC97 HEK-293T C800(1.21)  LDD0962  [4]
 LDCM0248  AKOS034007472 HEK-293T C472(0.99); C800(0.98)  LDD1511  [11]
 LDCM0356  AKOS034007680 HEK-293T C800(1.02); C291(1.01)  LDD1570  [11]
 LDCM0275  AKOS034007705 HEK-293T C472(1.01); C800(1.04); C291(1.01); C70(1.03)  LDD1514  [11]
 LDCM0632  CL-Sc Hep-G2 C472(20.00)  LDD2227  [8]
 LDCM0367  CL1 HEK-293T C472(0.93); C800(1.11); C291(1.04); C70(1.09)  LDD1571  [11]
 LDCM0368  CL10 HEK-293T C472(0.84); C800(1.07); C291(0.76); C41(1.28)  LDD1572  [11]
 LDCM0369  CL100 HEK-293T C472(1.16); C800(1.00); C291(0.97)  LDD1573  [11]
 LDCM0370  CL101 HEK-293T C472(1.02); C800(1.06); C291(1.05); C70(1.08)  LDD1574  [11]
 LDCM0371  CL102 HEK-293T C472(1.01); C800(0.91); C291(1.03); C41(1.27)  LDD1575  [11]
 LDCM0372  CL103 HEK-293T C800(1.09); C291(0.97); C70(1.03); C41(0.96)  LDD1576  [11]
 LDCM0373  CL104 HEK-293T C472(1.24); C800(1.03); C291(0.99)  LDD1577  [11]
 LDCM0374  CL105 HCT 116 C800(0.74)  LDD0691  [4]
 LDCM0375  CL106 HCT 116 C800(0.78)  LDD0692  [4]
 LDCM0376  CL107 HCT 116 C800(0.92)  LDD0693  [4]
 LDCM0377  CL108 HCT 116 C800(0.83)  LDD0694  [4]
 LDCM0378  CL109 HCT 116 C800(1.06)  LDD0695  [4]
 LDCM0379  CL11 HEK-293T C472(1.18); C800(1.03); C291(1.26)  LDD1583  [11]
 LDCM0380  CL110 HCT 116 C800(1.18)  LDD0697  [4]
 LDCM0381  CL111 HCT 116 C800(1.17)  LDD0698  [4]
 LDCM0382  CL112 HEK-293T C800(1.22)  LDD0980  [4]
 LDCM0383  CL113 HEK-293T C800(1.29)  LDD0981  [4]
 LDCM0384  CL114 HEK-293T C800(1.34)  LDD0982  [4]
 LDCM0385  CL115 HEK-293T C800(1.67)  LDD0983  [4]
 LDCM0386  CL116 HEK-293T C800(1.58)  LDD0984  [4]
 LDCM0387  CL117 HCT 116 C800(2.37)  LDD0704  [4]
 LDCM0388  CL118 HCT 116 C800(0.72)  LDD0705  [4]
 LDCM0389  CL119 HCT 116 C800(0.76)  LDD0706  [4]
 LDCM0390  CL12 HEK-293T C472(1.31); C800(1.11); C291(1.17); C70(1.25)  LDD1594  [11]
 LDCM0391  CL120 HCT 116 C800(0.65)  LDD0708  [4]
 LDCM0392  CL121 HCT 116 C800(0.60)  LDD0709  [4]
 LDCM0393  CL122 HCT 116 C800(1.22)  LDD0710  [4]
 LDCM0394  CL123 HCT 116 C800(2.02)  LDD0711  [4]
 LDCM0395  CL124 HCT 116 C800(1.20)  LDD0712  [4]
 LDCM0396  CL125 HEK-293T C472(1.00); C800(1.20); C291(1.16); C70(1.00)  LDD1600  [11]
 LDCM0397  CL126 HEK-293T C472(1.16); C800(0.96); C291(0.93); C41(0.97)  LDD1601  [11]
 LDCM0398  CL127 HEK-293T C800(1.05); C291(0.89); C70(1.10); C41(1.09)  LDD1602  [11]
 LDCM0399  CL128 HEK-293T C472(1.21); C800(1.02); C291(1.26)  LDD1603  [11]
 LDCM0400  CL13 HEK-293T C472(1.01); C800(1.24); C291(1.17); C70(1.06)  LDD1604  [11]
 LDCM0401  CL14 HEK-293T C472(1.07); C800(1.09); C291(1.00); C41(1.12)  LDD1605  [11]
 LDCM0402  CL15 HEK-293T C800(1.01); C291(0.84); C70(1.14); C41(1.00)  LDD1606  [11]
 LDCM0403  CL16 HEK-293T C472(1.24); C800(1.03); C291(0.98)  LDD1607  [11]
 LDCM0404  CL17 HEK-293T C800(1.07); C291(0.91)  LDD1608  [11]
 LDCM0405  CL18 HEK-293T C800(1.10); C291(1.09)  LDD1609  [11]
 LDCM0406  CL19 HEK-293T C472(1.32); C800(1.14); C291(1.02)  LDD1610  [11]
 LDCM0407  CL2 HEK-293T C472(1.17); C800(0.98); C291(1.00); C41(1.14)  LDD1611  [11]
 LDCM0408  CL20 HEK-293T C472(1.14); C800(0.97); C291(1.15); C612(1.14)  LDD1612  [11]
 LDCM0409  CL21 HEK-293T C472(1.10); C800(0.95)  LDD1613  [11]
 LDCM0410  CL22 HEK-293T C472(1.13); C800(0.98); C291(1.25); C41(1.10)  LDD1614  [11]
 LDCM0411  CL23 HEK-293T C472(1.15); C800(1.05); C291(1.40)  LDD1615  [11]
 LDCM0412  CL24 HEK-293T C472(1.10); C800(1.17); C291(1.11); C70(1.06)  LDD1616  [11]
 LDCM0413  CL25 HEK-293T C472(0.91); C800(1.16); C291(1.05); C70(1.06)  LDD1617  [11]
 LDCM0414  CL26 HEK-293T C472(1.08); C800(0.99); C291(1.02); C41(1.20)  LDD1618  [11]
 LDCM0415  CL27 HEK-293T C800(1.11); C291(1.02); C70(1.05); C41(1.11)  LDD1619  [11]
 LDCM0416  CL28 HEK-293T C472(1.01); C800(1.09); C291(0.91)  LDD1620  [11]
 LDCM0417  CL29 HEK-293T C800(1.08); C291(1.03)  LDD1621  [11]
 LDCM0418  CL3 HEK-293T C800(1.08); C291(1.03); C70(1.06); C41(1.38)  LDD1622  [11]
 LDCM0419  CL30 HEK-293T C800(1.13); C291(1.12)  LDD1623  [11]
 LDCM0420  CL31 HEK-293T C472(1.19); C800(1.27); C291(0.98)  LDD1624  [11]
 LDCM0421  CL32 HEK-293T C472(1.17); C800(1.03); C291(1.03); C612(1.08)  LDD1625  [11]
 LDCM0422  CL33 HEK-293T C472(0.80); C800(0.92)  LDD1626  [11]
 LDCM0423  CL34 HEK-293T C472(0.94); C800(0.92); C291(1.23); C41(1.26)  LDD1627  [11]
 LDCM0424  CL35 HEK-293T C472(1.09); C800(0.95); C291(1.19)  LDD1628  [11]
 LDCM0425  CL36 HEK-293T C472(1.09); C800(1.12); C291(1.08); C70(0.96)  LDD1629  [11]
 LDCM0426  CL37 HEK-293T C472(0.96); C800(1.10); C291(0.97); C70(0.99)  LDD1630  [11]
 LDCM0428  CL39 HEK-293T C800(1.02); C291(1.13); C70(1.00); C41(0.86)  LDD1632  [11]
 LDCM0429  CL4 HEK-293T C472(1.31); C800(1.03); C291(1.02)  LDD1633  [11]
 LDCM0430  CL40 HEK-293T C472(1.14); C800(1.14); C291(1.05)  LDD1634  [11]
 LDCM0431  CL41 HEK-293T C800(0.98); C291(0.96)  LDD1635  [11]
 LDCM0432  CL42 HEK-293T C800(0.95); C291(1.14)  LDD1636  [11]
 LDCM0433  CL43 HEK-293T C472(1.20); C800(1.24); C291(1.06)  LDD1637  [11]
 LDCM0434  CL44 HEK-293T C472(1.14); C800(1.06); C291(1.20); C612(1.13)  LDD1638  [11]
 LDCM0435  CL45 HEK-293T C472(0.86); C800(0.99)  LDD1639  [11]
 LDCM0436  CL46 HCT 116 C800(1.50)  LDD0753  [4]
 LDCM0437  CL47 HCT 116 C800(1.07)  LDD0754  [4]
 LDCM0438  CL48 HCT 116 C800(0.95)  LDD0755  [4]
 LDCM0439  CL49 HCT 116 C800(1.20)  LDD0756  [4]
 LDCM0440  CL5 HEK-293T C800(0.89); C291(1.00)  LDD1644  [11]
 LDCM0441  CL50 HCT 116 C800(0.95)  LDD0758  [4]
 LDCM0442  CL51 HCT 116 C800(1.38)  LDD0759  [4]
 LDCM0443  CL52 HCT 116 C800(1.12)  LDD0760  [4]
 LDCM0444  CL53 HCT 116 C800(0.68)  LDD0761  [4]
 LDCM0445  CL54 HCT 116 C800(1.42)  LDD0762  [4]
 LDCM0446  CL55 HCT 116 C800(0.89)  LDD0763  [4]
 LDCM0447  CL56 HCT 116 C800(0.84)  LDD0764  [4]
 LDCM0448  CL57 HCT 116 C800(1.04)  LDD0765  [4]
 LDCM0449  CL58 HCT 116 C800(1.47)  LDD0766  [4]
 LDCM0450  CL59 HCT 116 C800(1.05)  LDD0767  [4]
 LDCM0451  CL6 HEK-293T C800(1.12); C291(0.93)  LDD1654  [11]
 LDCM0452  CL60 HCT 116 C800(1.33)  LDD0769  [4]
 LDCM0453  CL61 HCT 116 C800(1.06)  LDD0770  [4]
 LDCM0454  CL62 HCT 116 C800(1.23)  LDD0771  [4]
 LDCM0455  CL63 HCT 116 C800(2.01)  LDD0772  [4]
 LDCM0456  CL64 HCT 116 C800(1.10)  LDD0773  [4]
 LDCM0457  CL65 HCT 116 C800(1.02)  LDD0774  [4]
 LDCM0458  CL66 HCT 116 C800(1.39)  LDD0775  [4]
 LDCM0459  CL67 HCT 116 C800(1.28)  LDD0776  [4]
 LDCM0460  CL68 HCT 116 C800(2.32)  LDD0777  [4]
 LDCM0461  CL69 HCT 116 C800(1.40)  LDD0778  [4]
 LDCM0462  CL7 HEK-293T C472(1.14); C800(1.01); C291(0.92)  LDD1665  [11]
 LDCM0463  CL70 HCT 116 C800(0.92)  LDD0780  [4]
 LDCM0464  CL71 HCT 116 C800(1.75)  LDD0781  [4]
 LDCM0465  CL72 HCT 116 C800(0.90)  LDD0782  [4]
 LDCM0466  CL73 HCT 116 C800(0.88)  LDD0783  [4]
 LDCM0467  CL74 HCT 116 C800(1.24)  LDD0784  [4]
 LDCM0469  CL76 HEK-293T C472(1.30); C800(1.05); C291(0.92)  LDD1672  [11]
 LDCM0470  CL77 HEK-293T C800(1.03); C291(1.02)  LDD1673  [11]
 LDCM0471  CL78 HEK-293T C800(1.14); C291(1.03)  LDD1674  [11]
 LDCM0472  CL79 HEK-293T C472(1.13); C800(1.00); C291(0.94)  LDD1675  [11]
 LDCM0473  CL8 HEK-293T C472(0.78); C800(0.77); C291(0.97); C612(0.86)  LDD1676  [11]
 LDCM0474  CL80 HEK-293T C472(1.10); C800(1.02); C291(1.25); C612(1.09)  LDD1677  [11]
 LDCM0475  CL81 HEK-293T C472(1.04); C800(0.94)  LDD1678  [11]
 LDCM0476  CL82 HEK-293T C472(0.99); C800(0.97); C291(1.06); C41(1.08)  LDD1679  [11]
 LDCM0477  CL83 HEK-293T C472(1.06); C800(0.91); C291(1.16)  LDD1680  [11]
 LDCM0478  CL84 HEK-293T C472(1.02); C800(1.07); C291(0.95); C70(1.13)  LDD1681  [11]
 LDCM0479  CL85 HEK-293T C472(0.93); C800(1.30); C291(1.12); C70(0.99)  LDD1682  [11]
 LDCM0480  CL86 HEK-293T C472(1.08); C800(0.90); C291(0.96); C41(1.13)  LDD1683  [11]
 LDCM0481  CL87 HEK-293T C800(1.00); C291(0.92); C70(1.10); C41(0.98)  LDD1684  [11]
 LDCM0482  CL88 HEK-293T C472(1.19); C800(1.07); C291(1.15)  LDD1685  [11]
 LDCM0483  CL89 HEK-293T C800(0.86); C291(1.05)  LDD1686  [11]
 LDCM0484  CL9 HEK-293T C472(1.04); C800(0.96)  LDD1687  [11]
 LDCM0485  CL90 HEK-293T C800(0.95); C291(0.91)  LDD1688  [11]
 LDCM0486  CL91 HEK-293T C472(1.05); C800(0.99); C291(1.00)  LDD1689  [11]
 LDCM0487  CL92 HEK-293T C472(0.94); C800(1.02); C291(1.18); C612(0.99)  LDD1690  [11]
 LDCM0488  CL93 HEK-293T C472(0.96); C800(0.98)  LDD1691  [11]
 LDCM0489  CL94 HEK-293T C472(1.09); C800(0.94); C291(0.95); C41(1.27)  LDD1692  [11]
 LDCM0490  CL95 HEK-293T C472(1.10); C800(0.90); C291(1.02)  LDD1693  [11]
 LDCM0491  CL96 HEK-293T C472(0.93); C800(0.96); C291(0.97); C70(1.08)  LDD1694  [11]
 LDCM0492  CL97 HEK-293T C472(0.94); C800(0.93); C291(0.91); C70(1.21)  LDD1695  [11]
 LDCM0493  CL98 HEK-293T C472(1.02); C800(0.99); C291(1.06); C41(1.09)  LDD1696  [11]
 LDCM0494  CL99 HEK-293T C800(1.12); C291(1.07); C70(1.08); C41(1.04)  LDD1697  [11]
 LDCM0495  E2913 HEK-293T C800(0.99); C291(1.08); C70(1.00); C41(0.89)  LDD1698  [11]
 LDCM0468  Fragment33 HCT 116 C800(1.07)  LDD0785  [4]
 LDCM0427  Fragment51 HEK-293T C472(1.08); C800(1.02); C291(1.14); C41(1.09)  LDD1631  [11]
 LDCM0022  KB02 HEK-293T C291(0.98); C472(0.96); C800(0.94); C663(1.14)  LDD1492  [11]
 LDCM0023  KB03 HEK-293T C291(0.98); C472(1.05); C800(1.03); C663(1.16)  LDD1497  [11]
 LDCM0024  KB05 COLO792 C291(0.97)  LDD3310  [12]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Other
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Centromere protein C (CENPC) CENP-C/MIF2 family Q03188
Histone H3-like centromeric protein A (CENPA) Histone H3 family P49450

References

1 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
2 An Azo Coupling-Based Chemoproteomic Approach to Systematically Profile the Tyrosine Reactivity in the Human Proteome. Anal Chem. 2021 Jul 27;93(29):10334-10342. doi: 10.1021/acs.analchem.1c01935. Epub 2021 Jul 12.
3 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
4 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
5 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
6 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
7 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
8 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
9 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
10 DFT-Guided Discovery of Ethynyl-Triazolyl-Phosphinates as Modular Electrophiles for Chemoselective Cysteine Bioconjugation and Profiling. Angew Chem Int Ed Engl. 2022 Oct 10;61(41):e202205348. doi: 10.1002/anie.202205348. Epub 2022 Aug 22.
Mass spectrometry data entry: PXD033004
11 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
12 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840