Details of the Target

General Information of Target

Target ID LDTP05329
Target Name Tyrosine-protein kinase transmembrane receptor ROR2 (ROR2)
Gene Name ROR2
Gene ID 4920
Synonyms
NTRKR2; Tyrosine-protein kinase transmembrane receptor ROR2; EC 2.7.10.1; Neurotrophic tyrosine kinase, receptor-related 2
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MARGSALPRRPLLCIPAVWAAAALLLSVSRTSGEVEVLDPNDPLGPLDGQDGPIPTLKGY
FLNFLEPVNNITIVQGQTAILHCKVAGNPPPNVRWLKNDAPVVQEPRRIIIRKTEYGSRL
RIQDLDTTDTGYYQCVATNGMKTITATGVLFVRLGPTHSPNHNFQDDYHEDGFCQPYRGI
ACARFIGNRTIYVDSLQMQGEIENRITAAFTMIGTSTHLSDQCSQFAIPSFCHFVFPLCD
ARSRTPKPRELCRDECEVLESDLCRQEYTIARSNPLILMRLQLPKCEALPMPESPDAANC
MRIGIPAERLGRYHQCYNGSGMDYRGTASTTKSGHQCQPWALQHPHSHHLSSTDFPELGG
GHAYCRNPGGQMEGPWCFTQNKNVRMELCDVPSCSPRDSSKMGILYILVPSIAIPLVIAC
LFFLVCMCRNKQKASASTPQRRQLMASPSQDMEMPLINQHKQAKLKEISLSAVRFMEELG
EDRFGKVYKGHLFGPAPGEQTQAVAIKTLKDKAEGPLREEFRHEAMLRARLQHPNVVCLL
GVVTKDQPLSMIFSYCSHGDLHEFLVMRSPHSDVGSTDDDRTVKSALEPPDFVHLVAQIA
AGMEYLSSHHVVHKDLATRNVLVYDKLNVKISDLGLFREVYAADYYKLLGNSLLPIRWMA
PEAIMYGKFSIDSDIWSYGVVLWEVFSYGLQPYCGYSNQDVVEMIRNRQVLPCPDDCPAW
VYALMIECWNEFPSRRPRFKDIHSRLRAWGNLSNYNSSAQTSGASNTTQTSSLSTSPVSN
VSNARYVGPKQKAPPFPQPQFIPMKGQIRPMVPPPQLYVPVNGYQPVPAYGAYLPNFYPV
QIPMQMAPQQVPPQMVPKPSSHHSGSGSTSTGYVTTAPSNTSMADRAALLSEGADDTQNA
PEDGAQSTVQEAEEEEEGSVPETELLGDCDTLQVDEAQVQLEA
Target Type
Clinical trial
Target Bioclass
Enzyme
Family
Protein kinase superfamily, Tyr protein kinase family, ROR subfamily
Subcellular location
Cell membrane
Function
Tyrosine-protein kinase receptor which may be involved in the early formation of the chondrocytes. It seems to be required for cartilage and growth plate development. Phosphorylates YWHAB, leading to induction of osteogenesis and bone formation. In contrast, has also been shown to have very little tyrosine kinase activity in vitro. May act as a receptor for wnt ligand WNT5A which may result in the inhibition of WNT3A-mediated signaling.
TTD ID
T91435
Uniprot ID
Q01974
DrugMap ID
TTUDPCI
Ensemble ID
ENST00000375708.4
HGNC ID
HGNC:10257
ChEMBL ID
CHEMBL2375201

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 2 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
OPA-S-S-alkyne
 Probe Info  		K382(1.95); K285(3.36); K113(6.49); K97(6.68)  LDD3494  [1]
DBIA
 Probe Info  		C538(1.13)  LDD0625  [2]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HEK-293T C538(0.97)  LDD1507  [3]
 LDCM0215  AC10 HEK-293T C538(0.96)  LDD1508  [3]
 LDCM0237  AC12 HEK-293T C538(1.11)  LDD1510  [3]
 LDCM0259  AC14 HEK-293T C538(1.00)  LDD1512  [3]
 LDCM0270  AC15 HEK-293T C538(0.99)  LDD1513  [3]
 LDCM0276  AC17 HEK-293T C538(0.89)  LDD1515  [3]
 LDCM0277  AC18 HEK-293T C538(0.90)  LDD1516  [3]
 LDCM0279  AC2 HEK-293T C538(0.94)  LDD1518  [3]
 LDCM0280  AC20 HEK-293T C538(1.02)  LDD1519  [3]
 LDCM0281  AC21 HEK-293T C538(0.98)  LDD1520  [3]
 LDCM0282  AC22 HEK-293T C538(1.03)  LDD1521  [3]
 LDCM0283  AC23 HEK-293T C538(0.99)  LDD1522  [3]
 LDCM0284  AC24 HEK-293T C538(1.14)  LDD1523  [3]
 LDCM0285  AC25 HEK-293T C538(0.93)  LDD1524  [3]
 LDCM0286  AC26 HEK-293T C538(0.92)  LDD1525  [3]
 LDCM0288  AC28 HEK-293T C538(0.96)  LDD1527  [3]
 LDCM0289  AC29 HEK-293T C538(0.93)  LDD1528  [3]
 LDCM0291  AC30 HEK-293T C538(0.97)  LDD1530  [3]
 LDCM0292  AC31 HEK-293T C538(0.97)  LDD1531  [3]
 LDCM0293  AC32 HEK-293T C538(1.07)  LDD1532  [3]
 LDCM0294  AC33 HEK-293T C538(1.00)  LDD1533  [3]
 LDCM0295  AC34 HEK-293T C538(0.92)  LDD1534  [3]
 LDCM0297  AC36 HEK-293T C538(1.03)  LDD1536  [3]
 LDCM0298  AC37 HEK-293T C538(1.07)  LDD1537  [3]
 LDCM0299  AC38 HEK-293T C538(0.99)  LDD1538  [3]
 LDCM0300  AC39 HEK-293T C538(0.98)  LDD1539  [3]
 LDCM0301  AC4 HEK-293T C538(1.00)  LDD1540  [3]
 LDCM0302  AC40 HEK-293T C538(1.08)  LDD1541  [3]
 LDCM0303  AC41 HEK-293T C538(0.99)  LDD1542  [3]
 LDCM0304  AC42 HEK-293T C538(0.94)  LDD1543  [3]
 LDCM0306  AC44 HEK-293T C538(1.05)  LDD1545  [3]
 LDCM0307  AC45 HEK-293T C538(1.04)  LDD1546  [3]
 LDCM0308  AC46 HCT 116 C538(1.13)  LDD0625  [2]
 LDCM0309  AC47 HCT 116 C538(0.96)  LDD0626  [2]
 LDCM0310  AC48 HCT 116 C538(0.97)  LDD0627  [2]
 LDCM0311  AC49 HCT 116 C538(1.11)  LDD0628  [2]
 LDCM0312  AC5 HEK-293T C538(1.16)  LDD1551  [3]
 LDCM0313  AC50 HCT 116 C538(0.91)  LDD0630  [2]
 LDCM0314  AC51 HCT 116 C538(0.80)  LDD0631  [2]
 LDCM0315  AC52 HCT 116 C538(0.96)  LDD0632  [2]
 LDCM0316  AC53 HCT 116 C538(0.76)  LDD0633  [2]
 LDCM0317  AC54 HCT 116 C538(0.76)  LDD0634  [2]
 LDCM0318  AC55 HCT 116 C538(1.04)  LDD0635  [2]
 LDCM0319  AC56 HCT 116 C538(0.76)  LDD0636  [2]
 LDCM0320  AC57 HEK-293T C538(0.94)  LDD1559  [3]
 LDCM0321  AC58 HEK-293T C538(0.99)  LDD1560  [3]
 LDCM0323  AC6 HEK-293T C538(1.14)  LDD1562  [3]
 LDCM0324  AC60 HEK-293T C538(1.07)  LDD1563  [3]
 LDCM0325  AC61 HEK-293T C538(0.99)  LDD1564  [3]
 LDCM0326  AC62 HEK-293T C538(1.07)  LDD1565  [3]
 LDCM0327  AC63 HEK-293T C538(1.08)  LDD1566  [3]
 LDCM0328  AC64 HEK-293T C538(1.14)  LDD1567  [3]
 LDCM0334  AC7 HEK-293T C538(1.00)  LDD1568  [3]
 LDCM0345  AC8 HEK-293T C538(1.05)  LDD1569  [3]
 LDCM0248  AKOS034007472 HEK-293T C538(1.04)  LDD1511  [3]
 LDCM0356  AKOS034007680 HEK-293T C538(0.98)  LDD1570  [3]
 LDCM0275  AKOS034007705 HEK-293T C538(1.06)  LDD1514  [3]
 LDCM0367  CL1 HEK-293T C538(0.92)  LDD1571  [3]
 LDCM0368  CL10 HEK-293T C538(0.97)  LDD1572  [3]
 LDCM0369  CL100 HEK-293T C538(1.03)  LDD1573  [3]
 LDCM0370  CL101 HEK-293T C538(1.00)  LDD1574  [3]
 LDCM0371  CL102 HEK-293T C538(0.98)  LDD1575  [3]
 LDCM0372  CL103 HEK-293T C538(0.96)  LDD1576  [3]
 LDCM0373  CL104 HEK-293T C538(0.99)  LDD1577  [3]
 LDCM0374  CL105 HEK-293T C538(1.06)  LDD1578  [3]
 LDCM0375  CL106 HEK-293T C538(0.96)  LDD1579  [3]
 LDCM0376  CL107 HEK-293T C538(1.01)  LDD1580  [3]
 LDCM0377  CL108 HEK-293T C538(0.95)  LDD1581  [3]
 LDCM0378  CL109 HEK-293T C538(1.05)  LDD1582  [3]
 LDCM0379  CL11 HEK-293T C538(0.91)  LDD1583  [3]
 LDCM0380  CL110 HEK-293T C538(0.90)  LDD1584  [3]
 LDCM0381  CL111 HEK-293T C538(0.98)  LDD1585  [3]
 LDCM0382  CL112 HEK-293T C538(1.01)  LDD1586  [3]
 LDCM0383  CL113 HEK-293T C538(0.85)  LDD1587  [3]
 LDCM0384  CL114 HEK-293T C538(0.93)  LDD1588  [3]
 LDCM0385  CL115 HEK-293T C538(0.99)  LDD1589  [3]
 LDCM0386  CL116 HEK-293T C538(0.96)  LDD1590  [3]
 LDCM0387  CL117 HEK-293T C538(0.93)  LDD1591  [3]
 LDCM0388  CL118 HEK-293T C538(0.92)  LDD1592  [3]
 LDCM0389  CL119 HEK-293T C538(1.18)  LDD1593  [3]
 LDCM0390  CL12 HEK-293T C538(1.09)  LDD1594  [3]
 LDCM0391  CL120 HEK-293T C538(1.04)  LDD1595  [3]
 LDCM0392  CL121 HCT 116 C538(0.98)  LDD0709  [2]
 LDCM0393  CL122 HCT 116 C538(0.91)  LDD0710  [2]
 LDCM0394  CL123 HCT 116 C538(0.96)  LDD0711  [2]
 LDCM0395  CL124 HCT 116 C538(1.08)  LDD0712  [2]
 LDCM0396  CL125 HEK-293T C538(0.94)  LDD1600  [3]
 LDCM0397  CL126 HEK-293T C538(1.07)  LDD1601  [3]
 LDCM0398  CL127 HEK-293T C538(1.11)  LDD1602  [3]
 LDCM0399  CL128 HEK-293T C538(1.10)  LDD1603  [3]
 LDCM0400  CL13 HEK-293T C538(0.96)  LDD1604  [3]
 LDCM0401  CL14 HEK-293T C538(1.03)  LDD1605  [3]
 LDCM0402  CL15 HEK-293T C538(1.01)  LDD1606  [3]
 LDCM0403  CL16 HEK-293T C538(1.00)  LDD1607  [3]
 LDCM0404  CL17 HEK-293T C538(0.88)  LDD1608  [3]
 LDCM0405  CL18 HEK-293T C538(0.94)  LDD1609  [3]
 LDCM0407  CL2 HEK-293T C538(0.93)  LDD1611  [3]
 LDCM0408  CL20 HEK-293T C538(1.09)  LDD1612  [3]
 LDCM0409  CL21 HEK-293T C538(0.88)  LDD1613  [3]
 LDCM0410  CL22 HEK-293T C538(1.07)  LDD1614  [3]
 LDCM0411  CL23 HEK-293T C538(0.99)  LDD1615  [3]
 LDCM0412  CL24 HEK-293T C538(1.06)  LDD1616  [3]
 LDCM0413  CL25 HEK-293T C538(0.79)  LDD1617  [3]
 LDCM0414  CL26 HEK-293T C538(0.95)  LDD1618  [3]
 LDCM0415  CL27 HEK-293T C538(1.10)  LDD1619  [3]
 LDCM0416  CL28 HEK-293T C538(1.06)  LDD1620  [3]
 LDCM0417  CL29 HEK-293T C538(0.97)  LDD1621  [3]
 LDCM0418  CL3 HEK-293T C538(1.10)  LDD1622  [3]
 LDCM0419  CL30 HEK-293T C538(0.83)  LDD1623  [3]
 LDCM0420  CL31 HCT 116 C538(0.88)  LDD0737  [2]
 LDCM0421  CL32 HCT 116 C538(0.91)  LDD0738  [2]
 LDCM0422  CL33 HCT 116 C538(0.99)  LDD0739  [2]
 LDCM0423  CL34 HCT 116 C538(0.99)  LDD0740  [2]
 LDCM0424  CL35 HCT 116 C538(1.06)  LDD0741  [2]
 LDCM0425  CL36 HCT 116 C538(0.97)  LDD0742  [2]
 LDCM0426  CL37 HCT 116 C538(0.93)  LDD0743  [2]
 LDCM0428  CL39 HCT 116 C538(0.90)  LDD0745  [2]
 LDCM0429  CL4 HEK-293T C538(0.98)  LDD1633  [3]
 LDCM0430  CL40 HCT 116 C538(0.88)  LDD0747  [2]
 LDCM0431  CL41 HCT 116 C538(0.96)  LDD0748  [2]
 LDCM0432  CL42 HCT 116 C538(0.98)  LDD0749  [2]
 LDCM0433  CL43 HCT 116 C538(0.89)  LDD0750  [2]
 LDCM0434  CL44 HCT 116 C538(0.90)  LDD0751  [2]
 LDCM0435  CL45 HCT 116 C538(0.98)  LDD0752  [2]
 LDCM0436  CL46 HCT 116 C538(1.21)  LDD0753  [2]
 LDCM0437  CL47 HCT 116 C538(1.11)  LDD0754  [2]
 LDCM0438  CL48 HCT 116 C538(1.14)  LDD0755  [2]
 LDCM0439  CL49 HCT 116 C538(1.09)  LDD0756  [2]
 LDCM0440  CL5 HEK-293T C538(1.02)  LDD1644  [3]
 LDCM0441  CL50 HCT 116 C538(1.14)  LDD0758  [2]
 LDCM0442  CL51 HCT 116 C538(0.95)  LDD0759  [2]
 LDCM0443  CL52 HCT 116 C538(1.00)  LDD0760  [2]
 LDCM0444  CL53 HCT 116 C538(1.19)  LDD0761  [2]
 LDCM0445  CL54 HCT 116 C538(0.96)  LDD0762  [2]
 LDCM0446  CL55 HCT 116 C538(0.91)  LDD0763  [2]
 LDCM0447  CL56 HCT 116 C538(1.04)  LDD0764  [2]
 LDCM0448  CL57 HCT 116 C538(1.06)  LDD0765  [2]
 LDCM0449  CL58 HCT 116 C538(1.10)  LDD0766  [2]
 LDCM0450  CL59 HCT 116 C538(0.98)  LDD0767  [2]
 LDCM0451  CL6 HEK-293T C538(0.93)  LDD1654  [3]
 LDCM0452  CL60 HCT 116 C538(1.15)  LDD0769  [2]
 LDCM0453  CL61 HCT 116 C538(1.10)  LDD0770  [2]
 LDCM0454  CL62 HCT 116 C538(1.07)  LDD0771  [2]
 LDCM0455  CL63 HCT 116 C538(1.09)  LDD0772  [2]
 LDCM0456  CL64 HCT 116 C538(1.08)  LDD0773  [2]
 LDCM0457  CL65 HCT 116 C538(0.97)  LDD0774  [2]
 LDCM0458  CL66 HCT 116 C538(1.15)  LDD0775  [2]
 LDCM0459  CL67 HCT 116 C538(0.90)  LDD0776  [2]
 LDCM0460  CL68 HCT 116 C538(1.12)  LDD0777  [2]
 LDCM0461  CL69 HCT 116 C538(1.00)  LDD0778  [2]
 LDCM0463  CL70 HCT 116 C538(1.00)  LDD0780  [2]
 LDCM0464  CL71 HCT 116 C538(1.02)  LDD0781  [2]
 LDCM0465  CL72 HCT 116 C538(1.22)  LDD0782  [2]
 LDCM0466  CL73 HCT 116 C538(1.09)  LDD0783  [2]
 LDCM0467  CL74 HCT 116 C538(1.02)  LDD0784  [2]
 LDCM0469  CL76 HEK-293T C538(1.01)  LDD1672  [3]
 LDCM0470  CL77 HEK-293T C538(0.95)  LDD1673  [3]
 LDCM0471  CL78 HEK-293T C538(0.82)  LDD1674  [3]
 LDCM0473  CL8 HEK-293T C538(0.97)  LDD1676  [3]
 LDCM0474  CL80 HEK-293T C538(1.10)  LDD1677  [3]
 LDCM0475  CL81 HEK-293T C538(1.03)  LDD1678  [3]
 LDCM0476  CL82 HEK-293T C538(1.06)  LDD1679  [3]
 LDCM0477  CL83 HEK-293T C538(0.93)  LDD1680  [3]
 LDCM0478  CL84 HEK-293T C538(1.05)  LDD1681  [3]
 LDCM0479  CL85 HEK-293T C538(1.10)  LDD1682  [3]
 LDCM0480  CL86 HEK-293T C538(0.97)  LDD1683  [3]
 LDCM0481  CL87 HEK-293T C538(1.13)  LDD1684  [3]
 LDCM0482  CL88 HEK-293T C538(1.00)  LDD1685  [3]
 LDCM0483  CL89 HEK-293T C538(0.97)  LDD1686  [3]
 LDCM0484  CL9 HEK-293T C538(1.03)  LDD1687  [3]
 LDCM0485  CL90 HEK-293T C538(0.87)  LDD1688  [3]
 LDCM0487  CL92 HEK-293T C538(1.02)  LDD1690  [3]
 LDCM0488  CL93 HEK-293T C538(0.92)  LDD1691  [3]
 LDCM0489  CL94 HEK-293T C538(1.13)  LDD1692  [3]
 LDCM0490  CL95 HEK-293T C538(0.74)  LDD1693  [3]
 LDCM0491  CL96 HEK-293T C538(1.06)  LDD1694  [3]
 LDCM0492  CL97 HEK-293T C538(1.09)  LDD1695  [3]
 LDCM0493  CL98 HEK-293T C538(1.03)  LDD1696  [3]
 LDCM0494  CL99 HEK-293T C538(1.05)  LDD1697  [3]
 LDCM0495  E2913 HEK-293T C538(0.97)  LDD1698  [3]
 LDCM0468  Fragment33 HCT 116 C538(0.98)  LDD0785  [2]
 LDCM0427  Fragment51 HCT 116 C538(0.99)  LDD0744  [2]
 LDCM0022  KB02 HEK-293T C538(1.03)  LDD1492  [3]
 LDCM0023  KB03 HEK-293T C538(0.98)  LDD1497  [3]
 LDCM0024  KB05 NB1 C538(2.03)  LDD3340  [4]

References

1 A chemical proteomics approach for global mapping of functional lysines on cell surface of living cell. Nat Commun. 2024 Apr 8;15(1):2997. doi: 10.1038/s41467-024-47033-w.
Mass spectrometry data entry: PXD042888
2 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
3 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
4 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840