Details of the Target

General Information of Target

Target ID LDTP05104
Target Name Phosphatidylinositol 5-phosphate 4-kinase type-2 beta (PIP4K2B)
Gene Name PIP4K2B
Gene ID 8396
Synonyms
PIP5K2B; Phosphatidylinositol 5-phosphate 4-kinase type-2 beta; EC 2.7.1.149; 1-phosphatidylinositol 5-phosphate 4-kinase 2-beta; Diphosphoinositide kinase 2-beta; Phosphatidylinositol 5-phosphate 4-kinase type II beta; PI(5)P 4-kinase type II beta; PIP4KII-beta; PtdIns(5)P-4-kinase isoform 2-beta
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MSSNCTSTTAVAVAPLSASKTKTKKKHFVCQKVKLFRASEPILSVLMWGVNHTINELSNV
PVPVMLMPDDFKAYSKIKVDNHLFNKENLPSRFKFKEYCPMVFRNLRERFGIDDQDYQNS
VTRSAPINSDSQGRCGTRFLTTYDRRFVIKTVSSEDVAEMHNILKKYHQFIVECHGNTLL
PQFLGMYRLTVDGVETYMVVTRNVFSHRLTVHRKYDLKGSTVAREASDKEKAKDLPTFKD
NDFLNEGQKLHVGEESKKNFLEKLKRDVEFLAQLKIMDYSLLVGIHDVDRAEQEEMEVEE
RAEDEECENDGVGGNLLCSYGTPPDSPGNLLSFPRFFGPGEFDPSVDVYAMKSHESSPKK
EVYFMAIIDILTPYDTKKKAAHAAKTVKHGAGAEISTVNPEQYSKRFNEFMSNILT
Target Bioclass
Enzyme
Subcellular location
Endoplasmic reticulum membrane
Function
Participates in the biosynthesis of phosphatidylinositol 4,5-bisphosphate. Preferentially utilizes GTP, rather than ATP, for PI(5)P phosphorylation and its activity reflects changes in direct proportion to the physiological GTP concentration. Its GTP-sensing activity is critical for metabolic adaptation. PIP4Ks negatively regulate insulin signaling through a catalytic-independent mechanism. They interact with PIP5Ks and suppress PIP5K-mediated PtdIns(4,5)P2 synthesis and insulin-dependent conversion to PtdIns(3,4,5)P3.
Uniprot ID
P78356
Ensemble ID
ENST00000613180.2
HGNC ID
HGNC:8998
ChEMBL ID
CHEMBL5667

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
DU145 SNV: p.M101V DBIA    Probe Info 
HUH28 SNV: p.S120L DBIA    Probe Info 
IGROV1 SNV: p.R123H DBIA    Probe Info 
MFE319 SNV: p.Y143H; p.S356N DBIA    Probe Info 
MOLT4 SNV: p.R146C IA-alkyne    Probe Info 
TOV21G SNV: p.R107L DBIA    Probe Info 

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 12 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		15.00  LDD0402  [1]
AHL-Pu-1
 Probe Info  		C99(2.37)  LDD0168  [2]
DBIA
 Probe Info  		C99(0.80)  LDD0625  [3]
ATP probe
 Probe Info  		K96(0.00); K239(0.00)  LDD0199  [4]
4-Iodoacetamidophenylacetylene
 Probe Info  		N.A.  LDD0038  [5]
IA-alkyne
 Probe Info  		C30(0.00); C99(0.00)  LDD0162  [6]
Lodoacetamide azide
 Probe Info  		N.A.  LDD0037  [5]
TFBX
 Probe Info  		N.A.  LDD0027  [7]
IPM
 Probe Info  		N.A.  LDD0005  [8]
Phosphinate-6
 Probe Info  		C30(0.00); C135(0.00)  LDD0018  [9]
AOyne
 Probe Info  		15.00  LDD0443  [10]
NAIA_5
 Probe Info  		N.A.  LDD2223  [11]
PAL-AfBPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
VE-P
 Probe Info  		N.A.  LDD0396  [12]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0025  4SU-RNA HEK-293T C99(2.37)  LDD0168  [2]
 LDCM0026  4SU-RNA+native RNA HEK-293T C99(2.59); C30(2.48)  LDD0169  [2]
 LDCM0214  AC1 HEK-293T C99(0.94)  LDD1507  [13]
 LDCM0215  AC10 HEK-293T C99(0.98)  LDD1508  [13]
 LDCM0226  AC11 HEK-293T C174(1.08)  LDD1509  [13]
 LDCM0270  AC15 HEK-293T C99(0.98)  LDD1513  [13]
 LDCM0276  AC17 HEK-293T C99(0.94)  LDD1515  [13]
 LDCM0277  AC18 HEK-293T C99(0.94)  LDD1516  [13]
 LDCM0278  AC19 HEK-293T C174(0.83)  LDD1517  [13]
 LDCM0279  AC2 HEK-293T C99(1.07)  LDD1518  [13]
 LDCM0281  AC21 HEK-293T C99(0.92)  LDD1520  [13]
 LDCM0283  AC23 HEK-293T C99(1.01)  LDD1522  [13]
 LDCM0284  AC24 HEK-293T C99(1.02)  LDD1523  [13]
 LDCM0285  AC25 HEK-293T C99(0.87)  LDD1524  [13]
 LDCM0286  AC26 HEK-293T C99(1.04)  LDD1525  [13]
 LDCM0287  AC27 HEK-293T C174(1.15)  LDD1526  [13]
 LDCM0289  AC29 HEK-293T C99(0.96)  LDD1528  [13]
 LDCM0290  AC3 HEK-293T C174(0.90)  LDD1529  [13]
 LDCM0292  AC31 HEK-293T C99(0.99)  LDD1531  [13]
 LDCM0293  AC32 HEK-293T C99(0.94)  LDD1532  [13]
 LDCM0294  AC33 HEK-293T C99(0.97)  LDD1533  [13]
 LDCM0295  AC34 HEK-293T C99(0.98)  LDD1534  [13]
 LDCM0296  AC35 HEK-293T C174(1.23)  LDD1535  [13]
 LDCM0298  AC37 HEK-293T C99(0.92)  LDD1537  [13]
 LDCM0300  AC39 HEK-293T C99(0.96)  LDD1539  [13]
 LDCM0302  AC40 HEK-293T C99(0.95)  LDD1541  [13]
 LDCM0303  AC41 HEK-293T C99(0.90)  LDD1542  [13]
 LDCM0304  AC42 HEK-293T C99(0.93)  LDD1543  [13]
 LDCM0305  AC43 HEK-293T C174(1.03)  LDD1544  [13]
 LDCM0307  AC45 HEK-293T C99(0.89)  LDD1546  [13]
 LDCM0308  AC46 HCT 116 C99(0.80)  LDD0625  [3]
 LDCM0309  AC47 HCT 116 C99(0.86)  LDD0626  [3]
 LDCM0310  AC48 HCT 116 C99(0.49)  LDD0627  [3]
 LDCM0311  AC49 HCT 116 C99(0.69)  LDD0628  [3]
 LDCM0312  AC5 HEK-293T C99(0.93)  LDD1551  [13]
 LDCM0313  AC50 HCT 116 C99(0.61)  LDD0630  [3]
 LDCM0314  AC51 HCT 116 C99(1.61)  LDD0631  [3]
 LDCM0315  AC52 HCT 116 C99(0.87)  LDD0632  [3]
 LDCM0316  AC53 HCT 116 C99(0.62)  LDD0633  [3]
 LDCM0317  AC54 HCT 116 C99(0.78)  LDD0634  [3]
 LDCM0318  AC55 HCT 116 C99(0.67)  LDD0635  [3]
 LDCM0319  AC56 HCT 116 C99(0.52)  LDD0636  [3]
 LDCM0320  AC57 HCT 116 C99(0.70)  LDD0637  [3]
 LDCM0321  AC58 HCT 116 C99(0.66)  LDD0638  [3]
 LDCM0322  AC59 HCT 116 C99(0.70)  LDD0639  [3]
 LDCM0324  AC60 HCT 116 C99(0.57)  LDD0641  [3]
 LDCM0325  AC61 HCT 116 C99(0.69)  LDD0642  [3]
 LDCM0326  AC62 HCT 116 C99(0.72)  LDD0643  [3]
 LDCM0327  AC63 HCT 116 C99(0.91)  LDD0644  [3]
 LDCM0328  AC64 HCT 116 C99(0.70)  LDD0645  [3]
 LDCM0329  AC65 HCT 116 C99(0.78)  LDD0646  [3]
 LDCM0330  AC66 HCT 116 C99(0.77)  LDD0647  [3]
 LDCM0331  AC67 HCT 116 C99(0.47)  LDD0648  [3]
 LDCM0334  AC7 HEK-293T C99(1.01)  LDD1568  [13]
 LDCM0345  AC8 HEK-293T C99(0.99)  LDD1569  [13]
 LDCM0248  AKOS034007472 HEK-293T C99(0.88)  LDD1511  [13]
 LDCM0356  AKOS034007680 HEK-293T C99(0.90)  LDD1570  [13]
 LDCM0275  AKOS034007705 HEK-293T C99(0.87)  LDD1514  [13]
 LDCM0156  Aniline NCI-H1299 11.95  LDD0403  [1]
 LDCM0367  CL1 HCT 116 C99(1.96)  LDD0684  [3]
 LDCM0368  CL10 HCT 116 C99(1.04)  LDD0685  [3]
 LDCM0369  CL100 HEK-293T C99(0.97); C174(0.72)  LDD1573  [13]
 LDCM0371  CL102 HEK-293T C99(0.93)  LDD1575  [13]
 LDCM0373  CL104 HEK-293T C99(1.01); C174(1.11)  LDD1577  [13]
 LDCM0375  CL106 HEK-293T C99(0.91)  LDD1579  [13]
 LDCM0377  CL108 HEK-293T C99(0.92); C174(0.86)  LDD1581  [13]
 LDCM0379  CL11 HCT 116 C99(0.94)  LDD0696  [3]
 LDCM0380  CL110 HEK-293T C99(0.81)  LDD1584  [13]
 LDCM0382  CL112 HEK-293T C99(0.94); C174(0.78)  LDD1586  [13]
 LDCM0384  CL114 HEK-293T C99(0.97)  LDD1588  [13]
 LDCM0386  CL116 HEK-293T C99(0.94); C174(0.77)  LDD1590  [13]
 LDCM0388  CL118 HEK-293T C99(1.05)  LDD1592  [13]
 LDCM0390  CL12 HCT 116 C99(0.99)  LDD0707  [3]
 LDCM0391  CL120 HEK-293T C99(0.95); C174(1.00)  LDD1595  [13]
 LDCM0392  CL121 HCT 116 C99(0.39)  LDD0709  [3]
 LDCM0393  CL122 HCT 116 C99(0.78)  LDD0710  [3]
 LDCM0394  CL123 HCT 116 C99(0.81)  LDD0711  [3]
 LDCM0395  CL124 HCT 116 C99(0.66)  LDD0712  [3]
 LDCM0396  CL125 HCT 116 C99(0.84)  LDD0713  [3]
 LDCM0397  CL126 HCT 116 C99(2.68)  LDD0714  [3]
 LDCM0398  CL127 HCT 116 C99(1.10)  LDD0715  [3]
 LDCM0399  CL128 HCT 116 C99(0.75)  LDD0716  [3]
 LDCM0400  CL13 HCT 116 C99(0.64)  LDD0717  [3]
 LDCM0401  CL14 HCT 116 C99(0.71)  LDD0718  [3]
 LDCM0402  CL15 HCT 116 C99(0.88)  LDD0719  [3]
 LDCM0403  CL16 HCT 116 C99(0.47)  LDD0720  [3]
 LDCM0404  CL17 HCT 116 C99(0.39)  LDD0721  [3]
 LDCM0405  CL18 HCT 116 C99(0.28)  LDD0722  [3]
 LDCM0406  CL19 HCT 116 C99(0.34)  LDD0723  [3]
 LDCM0407  CL2 HCT 116 C99(1.49)  LDD0724  [3]
 LDCM0408  CL20 HCT 116 C99(1.27)  LDD0725  [3]
 LDCM0409  CL21 HCT 116 C99(0.33)  LDD0726  [3]
 LDCM0410  CL22 HCT 116 C99(0.30)  LDD0727  [3]
 LDCM0411  CL23 HCT 116 C99(0.53)  LDD0728  [3]
 LDCM0412  CL24 HCT 116 C99(0.60)  LDD0729  [3]
 LDCM0413  CL25 HCT 116 C99(0.36)  LDD0730  [3]
 LDCM0414  CL26 HCT 116 C99(0.54)  LDD0731  [3]
 LDCM0415  CL27 HCT 116 C99(0.58)  LDD0732  [3]
 LDCM0416  CL28 HCT 116 C99(0.30)  LDD0733  [3]
 LDCM0417  CL29 HCT 116 C99(0.33)  LDD0734  [3]
 LDCM0418  CL3 HCT 116 C99(1.35)  LDD0735  [3]
 LDCM0419  CL30 HCT 116 C99(0.69)  LDD0736  [3]
 LDCM0420  CL31 HCT 116 C99(0.38)  LDD0737  [3]
 LDCM0421  CL32 HCT 116 C99(0.29)  LDD0738  [3]
 LDCM0422  CL33 HCT 116 C99(0.33)  LDD0739  [3]
 LDCM0423  CL34 HCT 116 C99(0.26)  LDD0740  [3]
 LDCM0424  CL35 HCT 116 C99(0.42)  LDD0741  [3]
 LDCM0425  CL36 HCT 116 C99(0.49)  LDD0742  [3]
 LDCM0426  CL37 HCT 116 C99(0.24)  LDD0743  [3]
 LDCM0428  CL39 HCT 116 C99(0.37)  LDD0745  [3]
 LDCM0429  CL4 HCT 116 C99(0.90)  LDD0746  [3]
 LDCM0430  CL40 HCT 116 C99(0.30)  LDD0747  [3]
 LDCM0431  CL41 HCT 116 C99(0.48)  LDD0748  [3]
 LDCM0432  CL42 HCT 116 C99(0.27)  LDD0749  [3]
 LDCM0433  CL43 HCT 116 C99(0.31)  LDD0750  [3]
 LDCM0434  CL44 HCT 116 C99(0.21)  LDD0751  [3]
 LDCM0435  CL45 HCT 116 C99(0.23)  LDD0752  [3]
 LDCM0437  CL47 HEK-293T C99(0.99)  LDD1641  [13]
 LDCM0438  CL48 HEK-293T C99(0.97)  LDD1642  [13]
 LDCM0440  CL5 HCT 116 C99(0.87)  LDD0757  [3]
 LDCM0441  CL50 HEK-293T C99(0.98)  LDD1645  [13]
 LDCM0443  CL52 HEK-293T C99(0.95); C174(0.87)  LDD1646  [13]
 LDCM0444  CL53 HEK-293T C99(0.10)  LDD1647  [13]
 LDCM0445  CL54 HEK-293T C99(0.91)  LDD1648  [13]
 LDCM0446  CL55 HEK-293T C174(1.03)  LDD1649  [13]
 LDCM0448  CL57 HEK-293T C99(0.75)  LDD1651  [13]
 LDCM0450  CL59 HEK-293T C99(1.00)  LDD1653  [13]
 LDCM0451  CL6 HCT 116 C99(0.65)  LDD0768  [3]
 LDCM0452  CL60 HEK-293T C99(0.96)  LDD1655  [13]
 LDCM0453  CL61 HCT 116 C99(1.03)  LDD0770  [3]
 LDCM0454  CL62 HCT 116 C99(0.82)  LDD0771  [3]
 LDCM0455  CL63 HCT 116 C99(1.03)  LDD0772  [3]
 LDCM0456  CL64 HCT 116 C99(0.65)  LDD0773  [3]
 LDCM0457  CL65 HCT 116 C99(0.69)  LDD0774  [3]
 LDCM0458  CL66 HCT 116 C99(0.56)  LDD0775  [3]
 LDCM0459  CL67 HCT 116 C99(0.75)  LDD0776  [3]
 LDCM0460  CL68 HCT 116 C99(0.57)  LDD0777  [3]
 LDCM0461  CL69 HCT 116 C99(0.73)  LDD0778  [3]
 LDCM0462  CL7 HCT 116 C99(0.93)  LDD0779  [3]
 LDCM0463  CL70 HCT 116 C99(0.60)  LDD0780  [3]
 LDCM0464  CL71 HCT 116 C99(1.04)  LDD0781  [3]
 LDCM0465  CL72 HCT 116 C99(1.05)  LDD0782  [3]
 LDCM0466  CL73 HCT 116 C99(0.75)  LDD0783  [3]
 LDCM0467  CL74 HCT 116 C99(0.80)  LDD0784  [3]
 LDCM0469  CL76 HEK-293T C99(1.11); C174(0.66)  LDD1672  [13]
 LDCM0470  CL77 HEK-293T C99(1.84)  LDD1673  [13]
 LDCM0471  CL78 HEK-293T C99(1.10)  LDD1674  [13]
 LDCM0472  CL79 HEK-293T C174(1.16)  LDD1675  [13]
 LDCM0473  CL8 HCT 116 C99(1.09)  LDD0790  [3]
 LDCM0475  CL81 HEK-293T C99(1.05)  LDD1678  [13]
 LDCM0477  CL83 HEK-293T C99(0.97)  LDD1680  [13]
 LDCM0478  CL84 HEK-293T C99(0.97)  LDD1681  [13]
 LDCM0480  CL86 HEK-293T C99(0.93)  LDD1683  [13]
 LDCM0482  CL88 HEK-293T C99(0.89); C174(0.82)  LDD1685  [13]
 LDCM0483  CL89 HEK-293T C99(0.98)  LDD1686  [13]
 LDCM0484  CL9 HCT 116 C99(1.10)  LDD0801  [3]
 LDCM0485  CL90 HEK-293T C99(0.99)  LDD1688  [13]
 LDCM0486  CL91 HEK-293T C174(0.77)  LDD1689  [13]
 LDCM0488  CL93 HEK-293T C99(0.88)  LDD1691  [13]
 LDCM0490  CL95 HEK-293T C99(0.86)  LDD1693  [13]
 LDCM0491  CL96 HEK-293T C99(0.47)  LDD1694  [13]
 LDCM0493  CL98 HEK-293T C99(0.91)  LDD1696  [13]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C30(0.95)  LDD1702  [14]
 LDCM0468  Fragment33 HCT 116 C99(0.80)  LDD0785  [3]
 LDCM0427  Fragment51 HCT 116 C99(0.39)  LDD0744  [3]
 LDCM0022  KB02 HEK-293T C99(1.01)  LDD1492  [13]
 LDCM0023  KB03 HEK-293T C99(0.97)  LDD1497  [13]
 LDCM0024  KB05 COLO792 C99(3.19)  LDD3310  [15]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Proteasome subunit beta type-1 (PSMB1) Peptidase T1B family P20618
Casein kinase II subunit alpha (CSNK2A1) Ser/Thr protein kinase family P68400
Transcription factor
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Homeobox-containing protein 1 (HMBOX1) . Q6NT76
Other
Click To Hide/Show 6 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
DNA mismatch repair protein Mlh1 (MLH1) DNA mismatch repair MutL/HexB family P40692
Heat shock protein beta-7 (HSPB7) Small heat shock protein (HSP20) family Q9UBY9
Regulation of nuclear pre-mRNA domain-containing protein 1B (RPRD1B) UPF0400 (RTT103) family Q9NQG5
Cell division cycle-associated 7-like protein (CDCA7L) . Q96GN5
INO80 complex subunit B (INO80B) . Q9C086
U4/U6 small nuclear ribonucleoprotein Prp3 (PRPF3) . O43395

The Drug(s) Related To This Target

Approved
Click To Hide/Show 1 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Fostamatinib Small molecular drug DB12010

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
3 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
4 Targeted Proteomic Approaches for Proteome-Wide Characterizations of the AMP-Binding Capacities of Kinases. J Proteome Res. 2022 Aug 5;21(8):2063-2070. doi: 10.1021/acs.jproteome.2c00225. Epub 2022 Jul 12.
5 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
6 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
7 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
8 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
9 DFT-Guided Discovery of Ethynyl-Triazolyl-Phosphinates as Modular Electrophiles for Chemoselective Cysteine Bioconjugation and Profiling. Angew Chem Int Ed Engl. 2022 Oct 10;61(41):e202205348. doi: 10.1002/anie.202205348. Epub 2022 Aug 22.
Mass spectrometry data entry: PXD033004
10 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
11 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
12 Pharmacological Targeting of Vacuolar H(+)-ATPase via Subunit V1G Combats Multidrug-Resistant Cancer. Cell Chem Biol. 2020 Nov 19;27(11):1359-1370.e8. doi: 10.1016/j.chembiol.2020.06.011. Epub 2020 Jul 9.
13 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
14 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
15 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840