Details of the Target

General Information of Target

Target ID LDTP04706
Target Name Homeobox protein PKNOX1 (PKNOX1)
Gene Name PKNOX1
Gene ID 5316
Synonyms
PREP1; Homeobox protein PKNOX1; Homeobox protein PREP-1; PBX/knotted homeobox 1
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MMATQTLSIDSYQDGQQMQVVTELKTEQDPNCSEPDAEGVSPPPVESQTPMDVDKQAIYR
HPLFPLLALLFEKCEQSTQGSEGTTSASFDVDIENFVRKQEKEGKPFFCEDPETDNLMVK
AIQVLRIHLLELEKVNELCKDFCSRYIACLKTKMNSETLLSGEPGSPYSPVQSQQIQSAI
TGTISPQGIVVPASALQQGNVAMATVAGGTVYQPVTVVTPQGQVVTQTLSPGTIRIQNSQ
LQLQLNQDLSILHQDDGSSKNKRGVLPKHATNVMRSWLFQHIGHPYPTEDEKKQIAAQTN
LTLLQVNNWFINARRRILQPMLDSSCSETPKTKKKTAQNRPVQRFWPDSIASGVAQPPPS
ELTMSEGAVVTITTPVNMNVDSLQSLSSDGATLAVQQVMMAGQSEDESVDSTEEDAGALA
PAHISGLVLENSDSLQ
Target Bioclass
Transcription factor
Family
TALE/MEIS homeobox family
Subcellular location
Nucleus
Function Activates transcription in the presence of PBX1A and HOXA1.
Uniprot ID
P55347
Ensemble ID
ENST00000291547.10
HGNC ID
HGNC:9022

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
LS180 SNV: p.L383P .
MCC26 SNV: p.S194F .
MOLT4 SNV: p.S77Y; p.T412I .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 9 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
AHL-Pu-1
 Probe Info  		C326(3.51)  LDD0169  [1]
DBIA
 Probe Info  		C326(0.95)  LDD0533  [2]
IA-alkyne
 Probe Info  		N.A.  LDD0165  [3]
Lodoacetamide azide
 Probe Info  		N.A.  LDD0037  [4]
NAIA_5
 Probe Info  		N.A.  LDD2225  [5]
IPM
 Probe Info  		N.A.  LDD0147  [6]
TFBX
 Probe Info  		C109(0.00); C149(0.00)  LDD0148  [6]
Phosphinate-6
 Probe Info  		C149(0.00); C326(0.00); C139(0.00)  LDD0018  [7]
W1
 Probe Info  		N.A.  LDD0236  [8]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0026  4SU-RNA+native RNA HEK-293T C326(3.51)  LDD0169  [1]
 LDCM0214  AC1 HEK-293T C109(0.83)  LDD0812  [2]
 LDCM0215  AC10 HEK-293T C109(0.88)  LDD0813  [2]
 LDCM0216  AC100 HCT 116 C326(0.95)  LDD0533  [2]
 LDCM0217  AC101 HCT 116 C326(0.94)  LDD0534  [2]
 LDCM0218  AC102 HCT 116 C326(0.95)  LDD0535  [2]
 LDCM0219  AC103 HCT 116 C326(1.13)  LDD0536  [2]
 LDCM0220  AC104 HCT 116 C326(1.13)  LDD0537  [2]
 LDCM0221  AC105 HCT 116 C326(1.14)  LDD0538  [2]
 LDCM0222  AC106 HCT 116 C326(1.15)  LDD0539  [2]
 LDCM0223  AC107 HCT 116 C326(1.27)  LDD0540  [2]
 LDCM0224  AC108 HCT 116 C326(0.82)  LDD0541  [2]
 LDCM0225  AC109 HCT 116 C326(0.75)  LDD0542  [2]
 LDCM0226  AC11 HEK-293T C109(0.98)  LDD0824  [2]
 LDCM0227  AC110 HCT 116 C326(0.72)  LDD0544  [2]
 LDCM0228  AC111 HCT 116 C326(0.82)  LDD0545  [2]
 LDCM0229  AC112 HCT 116 C326(0.94)  LDD0546  [2]
 LDCM0230  AC113 HEK-293T C109(1.08)  LDD0828  [2]
 LDCM0231  AC114 HEK-293T C109(0.99)  LDD0829  [2]
 LDCM0232  AC115 HEK-293T C109(0.87)  LDD0830  [2]
 LDCM0233  AC116 HEK-293T C109(1.00)  LDD0831  [2]
 LDCM0234  AC117 HEK-293T C109(0.66)  LDD0832  [2]
 LDCM0235  AC118 HEK-293T C109(0.62)  LDD0833  [2]
 LDCM0236  AC119 HEK-293T C109(0.52)  LDD0834  [2]
 LDCM0237  AC12 HEK-293T C109(1.04)  LDD0835  [2]
 LDCM0238  AC120 HEK-293T C109(0.79)  LDD0836  [2]
 LDCM0239  AC121 HEK-293T C109(0.54)  LDD0837  [2]
 LDCM0240  AC122 HEK-293T C109(0.50)  LDD0838  [2]
 LDCM0241  AC123 HEK-293T C109(0.43)  LDD0839  [2]
 LDCM0242  AC124 HEK-293T C109(0.56)  LDD0840  [2]
 LDCM0243  AC125 HEK-293T C109(0.45)  LDD0841  [2]
 LDCM0244  AC126 HEK-293T C109(0.50)  LDD0842  [2]
 LDCM0245  AC127 HEK-293T C109(0.57)  LDD0843  [2]
 LDCM0259  AC14 HEK-293T C109(0.86)  LDD0857  [2]
 LDCM0263  AC143 HCT 116 C326(0.93)  LDD0580  [2]
 LDCM0264  AC144 HCT 116 C326(1.24)  LDD0581  [2]
 LDCM0265  AC145 HCT 116 C326(1.12)  LDD0582  [2]
 LDCM0266  AC146 HCT 116 C326(1.10)  LDD0583  [2]
 LDCM0267  AC147 HCT 116 C326(1.45)  LDD0584  [2]
 LDCM0268  AC148 HCT 116 C326(1.02)  LDD0585  [2]
 LDCM0269  AC149 HCT 116 C326(0.93)  LDD0586  [2]
 LDCM0270  AC15 HEK-293T C109(0.68)  LDD0868  [2]
 LDCM0271  AC150 HCT 116 C326(0.91)  LDD0588  [2]
 LDCM0272  AC151 HCT 116 C326(1.46)  LDD0589  [2]
 LDCM0273  AC152 HCT 116 C326(1.11)  LDD0590  [2]
 LDCM0274  AC153 HCT 116 C326(1.19)  LDD0591  [2]
 LDCM0621  AC154 HCT 116 C326(1.22)  LDD2158  [2]
 LDCM0622  AC155 HCT 116 C326(1.13)  LDD2159  [2]
 LDCM0623  AC156 HCT 116 C326(0.92)  LDD2160  [2]
 LDCM0624  AC157 HCT 116 C326(1.42)  LDD2161  [2]
 LDCM0276  AC17 HEK-293T C109(0.58)  LDD0874  [2]
 LDCM0277  AC18 HEK-293T C109(0.67)  LDD0875  [2]
 LDCM0278  AC19 HEK-293T C109(0.93)  LDD0876  [2]
 LDCM0279  AC2 HEK-293T C109(0.84)  LDD0877  [2]
 LDCM0280  AC20 HEK-293T C109(0.67)  LDD0878  [2]
 LDCM0281  AC21 HEK-293T C109(0.76)  LDD0879  [2]
 LDCM0282  AC22 HEK-293T C109(0.54)  LDD0880  [2]
 LDCM0283  AC23 HEK-293T C109(0.41)  LDD0881  [2]
 LDCM0284  AC24 HEK-293T C109(0.91)  LDD0882  [2]
 LDCM0285  AC25 HEK-293T C326(0.92)  LDD1524  [9]
 LDCM0286  AC26 HEK-293T C326(1.01); C109(1.10)  LDD1525  [9]
 LDCM0287  AC27 HEK-293T C326(0.96); C109(1.11)  LDD1526  [9]
 LDCM0288  AC28 HEK-293T C326(1.04); C109(0.96)  LDD1527  [9]
 LDCM0289  AC29 HEK-293T C326(1.01); C109(1.01)  LDD1528  [9]
 LDCM0290  AC3 HEK-293T C109(0.81)  LDD0888  [2]
 LDCM0291  AC30 HEK-293T C326(0.95); C109(1.07)  LDD1530  [9]
 LDCM0292  AC31 HEK-293T C326(0.95); C109(1.13); C74(1.01)  LDD1531  [9]
 LDCM0293  AC32 HEK-293T C326(1.01); C109(0.98)  LDD1532  [9]
 LDCM0294  AC33 HEK-293T C326(0.95)  LDD1533  [9]
 LDCM0295  AC34 HEK-293T C326(0.95); C109(1.20)  LDD1534  [9]
 LDCM0296  AC35 HCT 116 C326(0.91)  LDD0613  [2]
 LDCM0297  AC36 HCT 116 C326(0.99)  LDD0614  [2]
 LDCM0298  AC37 HCT 116 C326(1.01)  LDD0615  [2]
 LDCM0299  AC38 HCT 116 C326(1.03)  LDD0616  [2]
 LDCM0300  AC39 HCT 116 C326(1.02)  LDD0617  [2]
 LDCM0301  AC4 HEK-293T C109(0.92)  LDD0899  [2]
 LDCM0302  AC40 HCT 116 C326(1.01)  LDD0619  [2]
 LDCM0303  AC41 HCT 116 C326(0.95)  LDD0620  [2]
 LDCM0304  AC42 HCT 116 C326(1.09)  LDD0621  [2]
 LDCM0305  AC43 HCT 116 C326(1.05)  LDD0622  [2]
 LDCM0306  AC44 HCT 116 C326(1.04)  LDD0623  [2]
 LDCM0307  AC45 HCT 116 C326(1.00)  LDD0624  [2]
 LDCM0308  AC46 HEK-293T C109(0.83)  LDD0906  [2]
 LDCM0309  AC47 HEK-293T C109(0.78)  LDD0907  [2]
 LDCM0310  AC48 HEK-293T C109(0.77)  LDD0908  [2]
 LDCM0311  AC49 HEK-293T C109(0.76)  LDD0909  [2]
 LDCM0312  AC5 HEK-293T C109(0.98)  LDD0910  [2]
 LDCM0313  AC50 HEK-293T C109(0.84)  LDD0911  [2]
 LDCM0314  AC51 HEK-293T C109(0.71)  LDD0912  [2]
 LDCM0315  AC52 HEK-293T C109(0.66)  LDD0913  [2]
 LDCM0316  AC53 HEK-293T C109(0.72)  LDD0914  [2]
 LDCM0317  AC54 HEK-293T C109(0.82)  LDD0915  [2]
 LDCM0318  AC55 HEK-293T C109(0.78)  LDD0916  [2]
 LDCM0319  AC56 HEK-293T C109(0.84)  LDD0917  [2]
 LDCM0320  AC57 HCT 116 C326(1.36)  LDD0637  [2]
 LDCM0321  AC58 HCT 116 C326(1.59)  LDD0638  [2]
 LDCM0322  AC59 HCT 116 C326(1.60)  LDD0639  [2]
 LDCM0323  AC6 HEK-293T C109(0.97)  LDD0921  [2]
 LDCM0324  AC60 HCT 116 C326(1.41)  LDD0641  [2]
 LDCM0325  AC61 HCT 116 C326(1.70)  LDD0642  [2]
 LDCM0326  AC62 HCT 116 C326(1.71)  LDD0643  [2]
 LDCM0327  AC63 HCT 116 C326(1.43)  LDD0644  [2]
 LDCM0328  AC64 HCT 116 C326(1.77)  LDD0645  [2]
 LDCM0329  AC65 HCT 116 C326(1.76)  LDD0646  [2]
 LDCM0330  AC66 HCT 116 C326(1.52)  LDD0647  [2]
 LDCM0331  AC67 HCT 116 C326(1.86)  LDD0648  [2]
 LDCM0332  AC68 HEK-293T C326(1.10)  LDD0930  [2]
 LDCM0333  AC69 HEK-293T C326(0.90)  LDD0931  [2]
 LDCM0334  AC7 HEK-293T C109(0.79)  LDD0932  [2]
 LDCM0335  AC70 HEK-293T C326(0.88)  LDD0933  [2]
 LDCM0336  AC71 HEK-293T C326(0.96)  LDD0934  [2]
 LDCM0337  AC72 HEK-293T C326(1.19)  LDD0935  [2]
 LDCM0338  AC73 HEK-293T C326(0.89)  LDD0936  [2]
 LDCM0339  AC74 HEK-293T C326(0.97)  LDD0937  [2]
 LDCM0340  AC75 HEK-293T C326(0.94)  LDD0938  [2]
 LDCM0341  AC76 HEK-293T C326(1.00)  LDD0939  [2]
 LDCM0342  AC77 HEK-293T C326(0.83)  LDD0940  [2]
 LDCM0343  AC78 HEK-293T C326(0.72)  LDD0941  [2]
 LDCM0344  AC79 HEK-293T C326(1.05)  LDD0942  [2]
 LDCM0345  AC8 HEK-293T C109(0.70)  LDD0943  [2]
 LDCM0346  AC80 HEK-293T C326(0.93)  LDD0944  [2]
 LDCM0347  AC81 HEK-293T C326(0.94)  LDD0945  [2]
 LDCM0348  AC82 HEK-293T C326(0.99)  LDD0946  [2]
 LDCM0365  AC98 HCT 116 C326(1.47)  LDD0682  [2]
 LDCM0366  AC99 HCT 116 C326(0.80)  LDD0683  [2]
 LDCM0248  AKOS034007472 HEK-293T C109(0.94)  LDD0846  [2]
 LDCM0356  AKOS034007680 HEK-293T C109(0.55)  LDD0954  [2]
 LDCM0275  AKOS034007705 HEK-293T C109(0.76)  LDD0873  [2]
 LDCM0632  CL-Sc Hep-G2 C326(0.78)  LDD2227  [5]
 LDCM0367  CL1 HEK-293T C109(1.14); C326(1.10)  LDD0965  [2]
 LDCM0368  CL10 HEK-293T C109(0.56); C326(0.96)  LDD0966  [2]
 LDCM0369  CL100 HEK-293T C109(0.81)  LDD0967  [2]
 LDCM0370  CL101 HEK-293T C109(0.56)  LDD0968  [2]
 LDCM0371  CL102 HEK-293T C109(0.61)  LDD0969  [2]
 LDCM0372  CL103 HEK-293T C109(0.61)  LDD0970  [2]
 LDCM0373  CL104 HEK-293T C109(0.74)  LDD0971  [2]
 LDCM0374  CL105 HEK-293T C109(0.81)  LDD0972  [2]
 LDCM0375  CL106 HEK-293T C109(0.69)  LDD0973  [2]
 LDCM0376  CL107 HEK-293T C109(0.77)  LDD0974  [2]
 LDCM0377  CL108 HEK-293T C109(0.85)  LDD0975  [2]
 LDCM0378  CL109 HEK-293T C109(0.89)  LDD0976  [2]
 LDCM0379  CL11 HEK-293T C109(0.75); C326(0.88)  LDD0977  [2]
 LDCM0380  CL110 HEK-293T C109(0.75)  LDD0978  [2]
 LDCM0381  CL111 HEK-293T C109(0.87)  LDD0979  [2]
 LDCM0382  CL112 HEK-293T C326(1.07); C109(0.96)  LDD1586  [9]
 LDCM0383  CL113 HEK-293T C326(0.87); C109(1.00); C74(0.98)  LDD1587  [9]
 LDCM0384  CL114 HEK-293T C326(0.91); C109(1.14)  LDD1588  [9]
 LDCM0385  CL115 HEK-293T C326(0.98); C109(1.11)  LDD1589  [9]
 LDCM0386  CL116 HEK-293T C326(1.01); C109(0.98)  LDD1590  [9]
 LDCM0387  CL117 HCT 116 C326(1.03)  LDD0704  [2]
 LDCM0388  CL118 HCT 116 C326(1.06)  LDD0705  [2]
 LDCM0389  CL119 HCT 116 C326(0.98)  LDD0706  [2]
 LDCM0390  CL12 HEK-293T C109(1.08); C326(0.92)  LDD0988  [2]
 LDCM0391  CL120 HCT 116 C326(0.91)  LDD0708  [2]
 LDCM0392  CL121 HEK-293T C109(0.67)  LDD0990  [2]
 LDCM0393  CL122 HEK-293T C109(0.78)  LDD0991  [2]
 LDCM0394  CL123 HEK-293T C109(0.81)  LDD0992  [2]
 LDCM0395  CL124 HEK-293T C109(0.85)  LDD0993  [2]
 LDCM0396  CL125 HCT 116 C326(1.12)  LDD0713  [2]
 LDCM0397  CL126 HCT 116 C326(1.22)  LDD0714  [2]
 LDCM0398  CL127 HCT 116 C326(1.16)  LDD0715  [2]
 LDCM0399  CL128 HCT 116 C326(1.62)  LDD0716  [2]
 LDCM0400  CL13 HEK-293T C109(0.78); C326(0.89)  LDD0998  [2]
 LDCM0401  CL14 HEK-293T C109(0.95); C326(0.83)  LDD0999  [2]
 LDCM0402  CL15 HEK-293T C109(0.55); C326(0.83)  LDD1000  [2]
 LDCM0403  CL16 HEK-293T C326(0.90)  LDD1001  [2]
 LDCM0404  CL17 HEK-293T C326(0.75)  LDD1002  [2]
 LDCM0405  CL18 HEK-293T C326(0.99)  LDD1003  [2]
 LDCM0406  CL19 HEK-293T C326(1.00)  LDD1004  [2]
 LDCM0407  CL2 HEK-293T C109(0.93); C326(0.92)  LDD1005  [2]
 LDCM0408  CL20 HEK-293T C326(1.03)  LDD1006  [2]
 LDCM0409  CL21 HEK-293T C326(1.05)  LDD1007  [2]
 LDCM0410  CL22 HEK-293T C326(1.10)  LDD1008  [2]
 LDCM0411  CL23 HEK-293T C326(0.90)  LDD1009  [2]
 LDCM0412  CL24 HEK-293T C326(0.86)  LDD1010  [2]
 LDCM0413  CL25 HEK-293T C326(0.92)  LDD1011  [2]
 LDCM0414  CL26 HEK-293T C326(0.87)  LDD1012  [2]
 LDCM0415  CL27 HEK-293T C326(1.02)  LDD1013  [2]
 LDCM0416  CL28 HEK-293T C326(0.92)  LDD1014  [2]
 LDCM0417  CL29 HEK-293T C326(1.00)  LDD1015  [2]
 LDCM0418  CL3 HEK-293T C109(0.52); C326(0.86)  LDD1016  [2]
 LDCM0419  CL30 HEK-293T C326(0.99)  LDD1017  [2]
 LDCM0420  CL31 HEK-293T C109(0.69)  LDD1018  [2]
 LDCM0421  CL32 HEK-293T C109(0.89)  LDD1019  [2]
 LDCM0422  CL33 HEK-293T C109(0.68)  LDD1020  [2]
 LDCM0423  CL34 HEK-293T C109(0.99)  LDD1021  [2]
 LDCM0424  CL35 HEK-293T C109(0.76)  LDD1022  [2]
 LDCM0425  CL36 HEK-293T C109(0.82)  LDD1023  [2]
 LDCM0426  CL37 HEK-293T C109(0.78)  LDD1024  [2]
 LDCM0428  CL39 HEK-293T C109(0.53)  LDD1026  [2]
 LDCM0429  CL4 HEK-293T C109(1.38); C326(0.96)  LDD1027  [2]
 LDCM0430  CL40 HEK-293T C109(0.92)  LDD1028  [2]
 LDCM0431  CL41 HEK-293T C109(0.60)  LDD1029  [2]
 LDCM0432  CL42 HEK-293T C109(0.62)  LDD1030  [2]
 LDCM0433  CL43 HEK-293T C109(0.62)  LDD1031  [2]
 LDCM0434  CL44 HEK-293T C109(0.77)  LDD1032  [2]
 LDCM0435  CL45 HEK-293T C109(0.61)  LDD1033  [2]
 LDCM0436  CL46 HCT 116 C326(1.09)  LDD0753  [2]
 LDCM0437  CL47 HCT 116 C326(0.95)  LDD0754  [2]
 LDCM0438  CL48 HCT 116 C326(0.97)  LDD0755  [2]
 LDCM0439  CL49 HCT 116 C326(1.07)  LDD0756  [2]
 LDCM0440  CL5 HEK-293T C109(0.61); C326(0.89)  LDD1038  [2]
 LDCM0441  CL50 HCT 116 C326(1.18)  LDD0758  [2]
 LDCM0442  CL51 HCT 116 C326(1.21)  LDD0759  [2]
 LDCM0443  CL52 HCT 116 C326(1.03)  LDD0760  [2]
 LDCM0444  CL53 HCT 116 C326(0.88)  LDD0761  [2]
 LDCM0445  CL54 HCT 116 C326(1.18)  LDD0762  [2]
 LDCM0446  CL55 HCT 116 C326(1.07)  LDD0763  [2]
 LDCM0447  CL56 HCT 116 C326(0.84)  LDD0764  [2]
 LDCM0448  CL57 HCT 116 C326(0.95)  LDD0765  [2]
 LDCM0449  CL58 HCT 116 C326(1.10)  LDD0766  [2]
 LDCM0450  CL59 HCT 116 C326(1.02)  LDD0767  [2]
 LDCM0451  CL6 HEK-293T C109(0.92); C326(1.03)  LDD1049  [2]
 LDCM0452  CL60 HCT 116 C326(1.16)  LDD0769  [2]
 LDCM0453  CL61 HEK-293T C109(0.68)  LDD1051  [2]
 LDCM0454  CL62 HEK-293T C109(0.65)  LDD1052  [2]
 LDCM0455  CL63 HEK-293T C109(0.63)  LDD1053  [2]
 LDCM0456  CL64 HEK-293T C109(0.77)  LDD1054  [2]
 LDCM0457  CL65 HEK-293T C109(0.66)  LDD1055  [2]
 LDCM0458  CL66 HEK-293T C109(0.72)  LDD1056  [2]
 LDCM0459  CL67 HEK-293T C109(0.62)  LDD1057  [2]
 LDCM0460  CL68 HEK-293T C109(0.51)  LDD1058  [2]
 LDCM0461  CL69 HEK-293T C109(0.66)  LDD1059  [2]
 LDCM0462  CL7 HEK-293T C109(0.75); C326(0.90)  LDD1060  [2]
 LDCM0463  CL70 HEK-293T C109(0.86)  LDD1061  [2]
 LDCM0464  CL71 HEK-293T C109(0.54)  LDD1062  [2]
 LDCM0465  CL72 HEK-293T C109(0.70)  LDD1063  [2]
 LDCM0466  CL73 HEK-293T C109(0.62)  LDD1064  [2]
 LDCM0467  CL74 HEK-293T C109(0.29)  LDD1065  [2]
 LDCM0469  CL76 HEK-293T C109(0.78)  LDD1067  [2]
 LDCM0470  CL77 HEK-293T C109(0.64)  LDD1068  [2]
 LDCM0471  CL78 HEK-293T C109(0.54)  LDD1069  [2]
 LDCM0472  CL79 HEK-293T C109(0.46)  LDD1070  [2]
 LDCM0473  CL8 HEK-293T C109(1.04); C326(0.73)  LDD1071  [2]
 LDCM0474  CL80 HEK-293T C109(0.50)  LDD1072  [2]
 LDCM0475  CL81 HEK-293T C109(0.51)  LDD1073  [2]
 LDCM0476  CL82 HEK-293T C109(0.79)  LDD1074  [2]
 LDCM0477  CL83 HEK-293T C109(0.83)  LDD1075  [2]
 LDCM0478  CL84 HEK-293T C109(0.44)  LDD1076  [2]
 LDCM0479  CL85 HEK-293T C109(0.52)  LDD1077  [2]
 LDCM0480  CL86 HEK-293T C109(0.43)  LDD1078  [2]
 LDCM0481  CL87 HEK-293T C109(0.54)  LDD1079  [2]
 LDCM0482  CL88 HEK-293T C109(0.59)  LDD1080  [2]
 LDCM0483  CL89 HEK-293T C109(0.68)  LDD1081  [2]
 LDCM0484  CL9 HEK-293T C109(1.28); C326(0.67)  LDD1082  [2]
 LDCM0485  CL90 HEK-293T C109(0.65)  LDD1083  [2]
 LDCM0486  CL91 HEK-293T C109(0.89)  LDD1084  [2]
 LDCM0487  CL92 HEK-293T C109(0.91)  LDD1085  [2]
 LDCM0488  CL93 HEK-293T C109(0.74)  LDD1086  [2]
 LDCM0489  CL94 HEK-293T C109(0.66)  LDD1087  [2]
 LDCM0490  CL95 HEK-293T C109(0.66)  LDD1088  [2]
 LDCM0491  CL96 HEK-293T C109(0.85)  LDD1089  [2]
 LDCM0492  CL97 HEK-293T C109(0.95)  LDD1090  [2]
 LDCM0493  CL98 HEK-293T C109(0.74)  LDD1091  [2]
 LDCM0494  CL99 HEK-293T C109(0.87)  LDD1092  [2]
 LDCM0495  E2913 HEK-293T C326(0.94); C109(0.99)  LDD1698  [9]
 LDCM0468  Fragment33 HEK-293T C109(0.33)  LDD1066  [2]
 LDCM0427  Fragment51 HEK-293T C109(1.11)  LDD1025  [2]
 LDCM0022  KB02 HEK-293T C326(1.16)  LDD1492  [9]
 LDCM0023  KB03 HEK-293T C326(1.08)  LDD1497  [9]
 LDCM0024  KB05 SKMEL24 C326(1.49)  LDD3323  [10]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Transporter and channel
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Nucleoporin p58/p45 (NUP58) NUP58 family Q9BVL2
Transcription factor
Click To Hide/Show 4 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
High mobility group protein B2 (HMGB2) HMGB family P26583
Krueppel-like factor 11 (KLF11) Sp1 C2H2-type zinc-finger protein family O14901
Pre-B-cell leukemia transcription factor 1 (PBX1) TALE/PBX homeobox family P40424
Pre-B-cell leukemia transcription factor 4 (PBX4) TALE/PBX homeobox family Q9BYU1
Other
Click To Hide/Show 6 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Biogenesis of lysosome-related organelles complex 1 subunit 5 (BLOC1S5) BLOC1S5 family Q8TDH9
BLOC-1-related complex subunit 6 (BORCS6) BORCS6 family Q96GS4
Protein FAM110B (FAM110B) FAM110 family Q8TC76
MAGUK p55 subfamily member 3 (MPP3) MAGUK family Q13368
Vacuolar protein sorting-associated protein 37C (VPS37C) VPS37 family A5D8V6
Four and a half LIM domains protein 2 (FHL2) . Q14192

References

1 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
2 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
3 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
4 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
5 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
6 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
7 DFT-Guided Discovery of Ethynyl-Triazolyl-Phosphinates as Modular Electrophiles for Chemoselective Cysteine Bioconjugation and Profiling. Angew Chem Int Ed Engl. 2022 Oct 10;61(41):e202205348. doi: 10.1002/anie.202205348. Epub 2022 Aug 22.
Mass spectrometry data entry: PXD033004
8 Oxidant-Induced Bioconjugation for Protein Labeling in Live Cells. ACS Chem Biol. 2023 Jan 20;18(1):112-122. doi: 10.1021/acschembio.2c00740. Epub 2022 Dec 21.
9 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
10 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840