Details of the Target

General Information of Target

Target ID LDTP04610
Target Name Mismatch repair endonuclease PMS2 (PMS2)
Gene Name PMS2
Gene ID 5395
Synonyms
PMSL2; Mismatch repair endonuclease PMS2; EC 3.1.-.-; DNA mismatch repair protein PMS2; PMS1 protein homolog 2
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MERAESSSTEPAKAIKPIDRKSVHQICSGQVVLSLSTAVKELVENSLDAGATNIDLKLKD
YGVDLIEVSDNGCGVEEENFEGLTLKHHTSKIQEFADLTQVETFGFRGEALSSLCALSDV
TISTCHASAKVGTRLMFDHNGKIIQKTPYPRPRGTTVSVQQLFSTLPVRHKEFQRNIKKE
YAKMVQVLHAYCIISAGIRVSCTNQLGQGKRQPVVCTGGSPSIKENIGSVFGQKQLQSLI
PFVQLPPSDSVCEEYGLSCSDALHNLFYISGFISQCTHGVGRSSTDRQFFFINRRPCDPA
KVCRLVNEVYHMYNRHQYPFVVLNISVDSECVDINVTPDKRQILLQEEKLLLAVLKTSLI
GMFDSDVNKLNVSQQPLLDVEGNLIKMHAADLEKPMVEKQDQSPSLRTGEEKKDVSISRL
REAFSLRHTTENKPHSPKTPEPRRSPLGQKRGMLSSSTSGAISDKGVLRPQKEAVSSSHG
PSDPTDRAEVEKDSGHGSTSVDSEGFSIPDTGSHCSSEYAASSPGDRGSQEHVDSQEKAP
KTDDSFSDVDCHSNQEDTGCKFRVLPQPTNLATPNTKRFKKEEILSSSDICQKLVNTQDM
SASQVDVAVKINKKVVPLDFSMSSLAKRIKQLHHEAQQSEGEQNYRKFRAKICPGENQAA
EDELRKEISKTMFAEMEIIGQFNLGFIITKLNEDIFIVDQHATDEKYNFEMLQQHTVLQG
QRLIAPQTLNLTAVNEAVLIENLEIFRKNGFDFVIDENAPVTERAKLISLPTSKNWTFGP
QDVDELIFMLSDSPGVMCRPSRVKQMFASRACRKSVMIGTALNTSEMKKLITHMGEMDHP
WNCPHGRPTMRHIANLGVISQN
Target Bioclass
Enzyme
Family
DNA mismatch repair MutL/HexB family
Subcellular location
Nucleus
Function
Component of the post-replicative DNA mismatch repair system (MMR). Heterodimerizes with MLH1 to form MutL alpha. DNA repair is initiated by MutS alpha (MSH2-MSH6) or MutS beta (MSH2-MSH3) binding to a dsDNA mismatch, then MutL alpha is recruited to the heteroduplex. Assembly of the MutL-MutS-heteroduplex ternary complex in presence of RFC and PCNA is sufficient to activate endonuclease activity of PMS2. It introduces single-strand breaks near the mismatch and thus generates new entry points for the exonuclease EXO1 to degrade the strand containing the mismatch. DNA methylation would prevent cleavage and therefore assure that only the newly mutated DNA strand is going to be corrected. MutL alpha (MLH1-PMS2) interacts physically with the clamp loader subunits of DNA polymerase III, suggesting that it may play a role to recruit the DNA polymerase III to the site of the MMR. Also implicated in DNA damage signaling, a process which induces cell cycle arrest and can lead to apoptosis in case of major DNA damages. Possesses an ATPase activity, but in the absence of gross structural changes, ATP hydrolysis may not be necessary for proficient mismatch repair.
Uniprot ID
P54278
Ensemble ID
ENST00000265849.12
HGNC ID
HGNC:9122

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
DU145 SNV: p.H189Y DBIA    Probe Info 
MFE319 Deletion: p.G466AfsTer3 .
OCUG1 SNV: p.Y313C DBIA    Probe Info 
SW1271 SNV: p.H88Y .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 15 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		15.00  LDD0402  [1]
BTD
 Probe Info  		C297(1.15)  LDD2112  [2]
AHL-Pu-1
 Probe Info  		C591(2.57); C653(9.71)  LDD0168  [3]
DBIA
 Probe Info  		C297(5.03)  LDD0209  [4]
4-Iodoacetamidophenylacetylene
 Probe Info  		C653(0.00); C202(0.00); C798(0.00)  LDD0038  [5]
IA-alkyne
 Probe Info  		C653(0.00); C798(0.00); C216(0.00); C202(0.00)  LDD0036  [5]
Lodoacetamide azide
 Probe Info  		C591(0.00); C653(0.00); C216(0.00); C202(0.00)  LDD0037  [5]
JW-RF-010
 Probe Info  		N.A.  LDD0026  [6]
NAIA_4
 Probe Info  		N.A.  LDD2226  [7]
WYneN
 Probe Info  		N.A.  LDD0021  [8]
WYneO
 Probe Info  		N.A.  LDD0022  [8]
IPM
 Probe Info  		C216(0.00); C653(0.00); C27(0.00); C591(0.00)  LDD0147  [6]
TFBX
 Probe Info  		C216(0.00); C202(0.00)  LDD0148  [6]
Acrolein
 Probe Info  		N.A.  LDD0217  [9]
NAIA_5
 Probe Info  		N.A.  LDD2223  [7]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0519  1-(6-methoxy-3,4-dihydroquinolin-1(2H)-yl)-2-nitroethan-1-one MDA-MB-231 C297(1.15)  LDD2112  [2]
 LDCM0025  4SU-RNA HEK-293T C591(2.57); C653(9.71)  LDD0168  [3]
 LDCM0026  4SU-RNA+native RNA HEK-293T C591(2.97); C653(10.27)  LDD0169  [3]
 LDCM0215  AC10 PaTu 8988t C551(1.20); C560(1.20)  LDD1094  [10]
 LDCM0216  AC100 PaTu 8988t C551(1.00); C560(1.00); C591(1.20)  LDD1095  [10]
 LDCM0217  AC101 PaTu 8988t C551(0.83); C560(0.83); C591(1.17)  LDD1096  [10]
 LDCM0218  AC102 PaTu 8988t C551(0.59); C560(0.59); C591(1.41)  LDD1097  [10]
 LDCM0219  AC103 PaTu 8988t C551(1.06); C560(1.06); C591(1.28)  LDD1098  [10]
 LDCM0220  AC104 PaTu 8988t C551(0.98); C560(0.98); C591(1.04)  LDD1099  [10]
 LDCM0221  AC105 PaTu 8988t C551(0.74); C560(0.74); C591(1.42)  LDD1100  [10]
 LDCM0222  AC106 PaTu 8988t C551(1.23); C560(1.23); C591(1.50)  LDD1101  [10]
 LDCM0223  AC107 PaTu 8988t C551(1.08); C560(1.08); C591(1.07)  LDD1102  [10]
 LDCM0224  AC108 PaTu 8988t C551(1.09); C560(1.09); C591(1.17)  LDD1103  [10]
 LDCM0225  AC109 PaTu 8988t C551(1.34); C560(1.34); C591(1.33)  LDD1104  [10]
 LDCM0226  AC11 PaTu 8988t C551(1.03); C560(1.03)  LDD1105  [10]
 LDCM0227  AC110 PaTu 8988t C551(0.94); C560(0.94); C591(1.32)  LDD1106  [10]
 LDCM0228  AC111 PaTu 8988t C551(1.17); C560(1.17); C591(1.88)  LDD1107  [10]
 LDCM0229  AC112 PaTu 8988t C551(0.79); C560(0.79); C591(1.37)  LDD1108  [10]
 LDCM0230  AC113 PaTu 8988t C551(1.00); C560(1.00); C591(0.93)  LDD1109  [10]
 LDCM0231  AC114 PaTu 8988t C551(0.80); C560(0.80); C591(0.84)  LDD1110  [10]
 LDCM0232  AC115 PaTu 8988t C551(1.28); C560(1.28); C591(0.93)  LDD1111  [10]
 LDCM0233  AC116 PaTu 8988t C551(0.89); C560(0.89); C591(0.90)  LDD1112  [10]
 LDCM0234  AC117 PaTu 8988t C551(1.14); C560(1.14); C591(0.92)  LDD1113  [10]
 LDCM0235  AC118 PaTu 8988t C551(0.88); C560(0.88); C591(0.93)  LDD1114  [10]
 LDCM0236  AC119 PaTu 8988t C551(0.72); C560(0.72); C591(0.88)  LDD1115  [10]
 LDCM0237  AC12 PaTu 8988t C551(1.07); C560(1.07)  LDD1116  [10]
 LDCM0238  AC120 PaTu 8988t C551(0.61); C560(0.61); C591(0.85)  LDD1117  [10]
 LDCM0239  AC121 PaTu 8988t C551(0.81); C560(0.81); C591(0.88)  LDD1118  [10]
 LDCM0240  AC122 PaTu 8988t C551(0.58); C560(0.58); C591(0.72)  LDD1119  [10]
 LDCM0241  AC123 PaTu 8988t C551(0.67); C560(0.67); C591(0.78)  LDD1120  [10]
 LDCM0242  AC124 PaTu 8988t C551(0.75); C560(0.75); C591(0.81)  LDD1121  [10]
 LDCM0243  AC125 PaTu 8988t C551(0.89); C560(0.89); C591(0.92)  LDD1122  [10]
 LDCM0244  AC126 PaTu 8988t C551(0.96); C560(0.96); C591(0.83)  LDD1123  [10]
 LDCM0245  AC127 PaTu 8988t C551(0.62); C560(0.62); C591(0.74)  LDD1124  [10]
 LDCM0246  AC128 PaTu 8988t C551(1.31); C560(1.31); C591(1.15)  LDD1125  [10]
 LDCM0247  AC129 PaTu 8988t C551(1.22); C560(1.22); C591(1.09)  LDD1126  [10]
 LDCM0249  AC130 PaTu 8988t C551(1.01); C560(1.01); C591(0.94)  LDD1128  [10]
 LDCM0250  AC131 PaTu 8988t C551(1.19); C560(1.19); C591(1.19)  LDD1129  [10]
 LDCM0251  AC132 PaTu 8988t C551(1.24); C560(1.24); C591(1.23)  LDD1130  [10]
 LDCM0252  AC133 PaTu 8988t C551(1.06); C560(1.06); C591(2.01)  LDD1131  [10]
 LDCM0253  AC134 PaTu 8988t C551(0.91); C560(0.91); C591(1.31)  LDD1132  [10]
 LDCM0254  AC135 PaTu 8988t C551(1.32); C560(1.32); C591(1.66)  LDD1133  [10]
 LDCM0255  AC136 PaTu 8988t C551(1.50); C560(1.50); C591(1.48)  LDD1134  [10]
 LDCM0256  AC137 PaTu 8988t C551(1.53); C560(1.53); C591(1.85)  LDD1135  [10]
 LDCM0257  AC138 PaTu 8988t C551(1.54); C560(1.54); C591(0.98)  LDD1136  [10]
 LDCM0258  AC139 PaTu 8988t C551(1.80); C560(1.80); C591(1.23)  LDD1137  [10]
 LDCM0259  AC14 PaTu 8988t C551(1.07); C560(1.07)  LDD1138  [10]
 LDCM0260  AC140 PaTu 8988t C551(1.86); C560(1.86); C591(1.17)  LDD1139  [10]
 LDCM0261  AC141 PaTu 8988t C551(1.59); C560(1.59); C591(0.94)  LDD1140  [10]
 LDCM0262  AC142 PaTu 8988t C551(1.19); C560(1.19); C591(1.14)  LDD1141  [10]
 LDCM0270  AC15 PaTu 8988t C551(1.38); C560(1.38)  LDD1149  [10]
 LDCM0276  AC17 PaTu 8988t C551(1.71); C560(1.71); C591(0.81)  LDD1155  [10]
 LDCM0277  AC18 PaTu 8988t C551(1.52); C560(1.52); C591(1.12)  LDD1156  [10]
 LDCM0278  AC19 PaTu 8988t C551(1.63); C560(1.63); C591(0.92)  LDD1157  [10]
 LDCM0280  AC20 PaTu 8988t C551(2.15); C560(2.15); C591(1.16)  LDD1159  [10]
 LDCM0281  AC21 PaTu 8988t C551(1.80); C560(1.80); C591(0.89)  LDD1160  [10]
 LDCM0282  AC22 PaTu 8988t C551(1.76); C560(1.76); C591(1.08)  LDD1161  [10]
 LDCM0283  AC23 PaTu 8988t C551(2.25); C560(2.25); C591(1.20)  LDD1162  [10]
 LDCM0284  AC24 PaTu 8988t C551(1.94); C560(1.94); C591(1.12)  LDD1163  [10]
 LDCM0285  AC25 PaTu 8988t C551(1.19); C560(1.19)  LDD1164  [10]
 LDCM0286  AC26 PaTu 8988t C551(0.96); C560(0.96)  LDD1165  [10]
 LDCM0287  AC27 PaTu 8988t C551(1.18); C560(1.18)  LDD1166  [10]
 LDCM0288  AC28 PaTu 8988t C551(1.37); C560(1.37)  LDD1167  [10]
 LDCM0289  AC29 PaTu 8988t C551(0.98); C560(0.98)  LDD1168  [10]
 LDCM0291  AC30 PaTu 8988t C551(0.96); C560(0.96)  LDD1170  [10]
 LDCM0292  AC31 PaTu 8988t C551(1.06); C560(1.06)  LDD1171  [10]
 LDCM0293  AC32 PaTu 8988t C551(1.11); C560(1.11)  LDD1172  [10]
 LDCM0294  AC33 PaTu 8988t C551(1.69); C560(1.69)  LDD1173  [10]
 LDCM0295  AC34 PaTu 8988t C551(1.14); C560(1.14)  LDD1174  [10]
 LDCM0296  AC35 PaTu 8988t C551(1.06); C560(1.06)  LDD1175  [10]
 LDCM0297  AC36 PaTu 8988t C551(1.38); C560(1.38)  LDD1176  [10]
 LDCM0298  AC37 PaTu 8988t C551(1.45); C560(1.45)  LDD1177  [10]
 LDCM0299  AC38 PaTu 8988t C551(1.44); C560(1.44)  LDD1178  [10]
 LDCM0300  AC39 PaTu 8988t C551(1.58); C560(1.58)  LDD1179  [10]
 LDCM0302  AC40 PaTu 8988t C551(1.58); C560(1.58)  LDD1181  [10]
 LDCM0303  AC41 PaTu 8988t C551(0.96); C560(0.96)  LDD1182  [10]
 LDCM0304  AC42 PaTu 8988t C551(1.14); C560(1.14)  LDD1183  [10]
 LDCM0305  AC43 PaTu 8988t C551(1.29); C560(1.29)  LDD1184  [10]
 LDCM0306  AC44 PaTu 8988t C551(1.37); C560(1.37)  LDD1185  [10]
 LDCM0307  AC45 PaTu 8988t C551(1.14); C560(1.14)  LDD1186  [10]
 LDCM0308  AC46 PaTu 8988t C551(1.00); C560(1.00)  LDD1187  [10]
 LDCM0309  AC47 PaTu 8988t C551(1.12); C560(1.12)  LDD1188  [10]
 LDCM0310  AC48 PaTu 8988t C551(1.44); C560(1.44)  LDD1189  [10]
 LDCM0311  AC49 PaTu 8988t C551(1.43); C560(1.43)  LDD1190  [10]
 LDCM0313  AC50 PaTu 8988t C551(1.09); C560(1.09)  LDD1192  [10]
 LDCM0314  AC51 PaTu 8988t C551(0.84); C560(0.84)  LDD1193  [10]
 LDCM0315  AC52 PaTu 8988t C551(1.06); C560(1.06)  LDD1194  [10]
 LDCM0316  AC53 PaTu 8988t C551(1.65); C560(1.65)  LDD1195  [10]
 LDCM0317  AC54 PaTu 8988t C551(1.61); C560(1.61)  LDD1196  [10]
 LDCM0318  AC55 PaTu 8988t C551(1.25); C560(1.25)  LDD1197  [10]
 LDCM0319  AC56 PaTu 8988t C551(1.30); C560(1.30)  LDD1198  [10]
 LDCM0323  AC6 PaTu 8988t C551(1.24); C560(1.24)  LDD1202  [10]
 LDCM0332  AC68 PaTu 8988t C551(0.94); C560(0.94)  LDD1211  [10]
 LDCM0333  AC69 PaTu 8988t C551(1.20); C560(1.20)  LDD1212  [10]
 LDCM0334  AC7 PaTu 8988t C551(0.95); C560(0.95)  LDD1213  [10]
 LDCM0335  AC70 PaTu 8988t C551(1.18); C560(1.18)  LDD1214  [10]
 LDCM0336  AC71 PaTu 8988t C551(0.92); C560(0.92)  LDD1215  [10]
 LDCM0337  AC72 PaTu 8988t C551(0.79); C560(0.79)  LDD1216  [10]
 LDCM0338  AC73 PaTu 8988t C551(0.87); C560(0.87)  LDD1217  [10]
 LDCM0339  AC74 PaTu 8988t C551(0.94); C560(0.94)  LDD1218  [10]
 LDCM0340  AC75 PaTu 8988t C551(1.15); C560(1.15)  LDD1219  [10]
 LDCM0341  AC76 PaTu 8988t C551(1.05); C560(1.05)  LDD1220  [10]
 LDCM0342  AC77 PaTu 8988t C551(0.88); C560(0.88)  LDD1221  [10]
 LDCM0343  AC78 PaTu 8988t C551(0.88); C560(0.88)  LDD1222  [10]
 LDCM0344  AC79 PaTu 8988t C551(0.82); C560(0.82)  LDD1223  [10]
 LDCM0345  AC8 PaTu 8988t C551(0.85); C560(0.85)  LDD1224  [10]
 LDCM0346  AC80 PaTu 8988t C551(0.90); C560(0.90)  LDD1225  [10]
 LDCM0347  AC81 PaTu 8988t C551(0.94); C560(0.94)  LDD1226  [10]
 LDCM0348  AC82 PaTu 8988t C551(0.81); C560(0.81)  LDD1227  [10]
 LDCM0349  AC83 PaTu 8988t C551(0.81); C560(0.81)  LDD1228  [10]
 LDCM0350  AC84 PaTu 8988t C551(0.60); C560(0.60)  LDD1229  [10]
 LDCM0351  AC85 PaTu 8988t C551(0.95); C560(0.95)  LDD1230  [10]
 LDCM0352  AC86 PaTu 8988t C551(0.77); C560(0.77)  LDD1231  [10]
 LDCM0353  AC87 PaTu 8988t C551(0.98); C560(0.98)  LDD1232  [10]
 LDCM0354  AC88 PaTu 8988t C551(0.88); C560(0.88)  LDD1233  [10]
 LDCM0355  AC89 PaTu 8988t C551(0.63); C560(0.63)  LDD1234  [10]
 LDCM0357  AC90 PaTu 8988t C551(0.66); C560(0.66)  LDD1236  [10]
 LDCM0358  AC91 PaTu 8988t C551(1.16); C560(1.16)  LDD1237  [10]
 LDCM0359  AC92 PaTu 8988t C551(0.67); C560(0.67)  LDD1238  [10]
 LDCM0360  AC93 PaTu 8988t C551(0.62); C560(0.62)  LDD1239  [10]
 LDCM0361  AC94 PaTu 8988t C551(0.88); C560(0.88)  LDD1240  [10]
 LDCM0362  AC95 PaTu 8988t C551(0.72); C560(0.72)  LDD1241  [10]
 LDCM0363  AC96 PaTu 8988t C551(0.54); C560(0.54)  LDD1242  [10]
 LDCM0364  AC97 PaTu 8988t C551(0.58); C560(0.58)  LDD1243  [10]
 LDCM0365  AC98 PaTu 8988t C551(1.04); C560(1.04); C591(1.37)  LDD1244  [10]
 LDCM0366  AC99 PaTu 8988t C551(0.89); C560(0.89); C591(1.22)  LDD1245  [10]
 LDCM0248  AKOS034007472 PaTu 8988t C551(1.27); C560(1.27)  LDD1127  [10]
 LDCM0356  AKOS034007680 PaTu 8988t C551(1.41); C560(1.41)  LDD1235  [10]
 LDCM0275  AKOS034007705 PaTu 8988t C551(1.32); C560(1.32)  LDD1154  [10]
 LDCM0156  Aniline NCI-H1299 12.03  LDD0403  [1]
 LDCM0632  CL-Sc Hep-G2 C653(0.98); C216(0.44)  LDD2227  [7]
 LDCM0370  CL101 PaTu 8988t C551(1.03); C560(1.03)  LDD1249  [10]
 LDCM0371  CL102 PaTu 8988t C551(1.23); C560(1.23)  LDD1250  [10]
 LDCM0372  CL103 PaTu 8988t C551(1.27); C560(1.27)  LDD1251  [10]
 LDCM0373  CL104 PaTu 8988t C551(1.55); C560(1.55)  LDD1252  [10]
 LDCM0374  CL105 PaTu 8988t C551(1.48); C560(1.48); C591(1.01)  LDD1253  [10]
 LDCM0375  CL106 PaTu 8988t C551(1.47); C560(1.47); C591(1.21)  LDD1254  [10]
 LDCM0376  CL107 PaTu 8988t C551(1.55); C560(1.55); C591(0.95)  LDD1255  [10]
 LDCM0377  CL108 PaTu 8988t C551(1.50); C560(1.50); C591(1.06)  LDD1256  [10]
 LDCM0378  CL109 PaTu 8988t C551(1.61); C560(1.61); C591(1.12)  LDD1257  [10]
 LDCM0380  CL110 PaTu 8988t C551(2.49); C560(2.49); C591(1.47)  LDD1259  [10]
 LDCM0381  CL111 PaTu 8988t C551(2.38); C560(2.38); C591(1.27)  LDD1260  [10]
 LDCM0382  CL112 PaTu 8988t C551(1.24); C560(1.24)  LDD1261  [10]
 LDCM0383  CL113 PaTu 8988t C551(0.95); C560(0.95)  LDD1262  [10]
 LDCM0384  CL114 PaTu 8988t C551(1.50); C560(1.50)  LDD1263  [10]
 LDCM0385  CL115 PaTu 8988t C551(1.32); C560(1.32)  LDD1264  [10]
 LDCM0386  CL116 PaTu 8988t C551(1.33); C560(1.33)  LDD1265  [10]
 LDCM0387  CL117 PaTu 8988t C551(1.27); C560(1.27)  LDD1266  [10]
 LDCM0388  CL118 PaTu 8988t C551(1.00); C560(1.00)  LDD1267  [10]
 LDCM0389  CL119 PaTu 8988t C551(1.22); C560(1.22)  LDD1268  [10]
 LDCM0391  CL120 PaTu 8988t C551(1.23); C560(1.23)  LDD1270  [10]
 LDCM0392  CL121 PaTu 8988t C551(1.25); C560(1.25)  LDD1271  [10]
 LDCM0393  CL122 PaTu 8988t C551(1.16); C560(1.16)  LDD1272  [10]
 LDCM0394  CL123 PaTu 8988t C551(1.43); C560(1.43)  LDD1273  [10]
 LDCM0395  CL124 PaTu 8988t C551(1.38); C560(1.38)  LDD1274  [10]
 LDCM0420  CL31 PaTu 8988t C591(1.06)  LDD1299  [10]
 LDCM0421  CL32 PaTu 8988t C591(1.21)  LDD1300  [10]
 LDCM0422  CL33 PaTu 8988t C591(1.18)  LDD1301  [10]
 LDCM0423  CL34 PaTu 8988t C591(1.29)  LDD1302  [10]
 LDCM0424  CL35 PaTu 8988t C591(1.46)  LDD1303  [10]
 LDCM0425  CL36 PaTu 8988t C591(1.10)  LDD1304  [10]
 LDCM0426  CL37 PaTu 8988t C591(1.42)  LDD1305  [10]
 LDCM0428  CL39 PaTu 8988t C591(1.26)  LDD1307  [10]
 LDCM0430  CL40 PaTu 8988t C591(1.09)  LDD1309  [10]
 LDCM0431  CL41 PaTu 8988t C591(1.16)  LDD1310  [10]
 LDCM0432  CL42 PaTu 8988t C591(1.41)  LDD1311  [10]
 LDCM0433  CL43 PaTu 8988t C591(1.36)  LDD1312  [10]
 LDCM0434  CL44 PaTu 8988t C591(1.61)  LDD1313  [10]
 LDCM0435  CL45 PaTu 8988t C591(1.73)  LDD1314  [10]
 LDCM0436  CL46 PaTu 8988t C551(0.94); C560(0.94)  LDD1315  [10]
 LDCM0437  CL47 PaTu 8988t C551(1.74); C560(1.74)  LDD1316  [10]
 LDCM0438  CL48 PaTu 8988t C551(1.18); C560(1.18)  LDD1317  [10]
 LDCM0439  CL49 PaTu 8988t C551(1.23); C560(1.23)  LDD1318  [10]
 LDCM0441  CL50 PaTu 8988t C551(0.98); C560(0.98)  LDD1320  [10]
 LDCM0442  CL51 PaTu 8988t C551(1.04); C560(1.04)  LDD1321  [10]
 LDCM0443  CL52 PaTu 8988t C551(0.67); C560(0.67)  LDD1322  [10]
 LDCM0444  CL53 PaTu 8988t C551(20.00); C560(20.00)  LDD1323  [10]
 LDCM0445  CL54 PaTu 8988t C551(0.84); C560(0.84)  LDD1324  [10]
 LDCM0446  CL55 PaTu 8988t C551(2.13); C560(2.13)  LDD1325  [10]
 LDCM0447  CL56 PaTu 8988t C551(1.20); C560(1.20)  LDD1326  [10]
 LDCM0448  CL57 PaTu 8988t C551(0.92); C560(0.92)  LDD1327  [10]
 LDCM0449  CL58 PaTu 8988t C551(1.16); C560(1.16)  LDD1328  [10]
 LDCM0450  CL59 PaTu 8988t C551(0.97); C560(0.97)  LDD1329  [10]
 LDCM0452  CL60 PaTu 8988t C551(1.09); C560(1.09)  LDD1331  [10]
 LDCM0634  CY-0357 Hep-G2 C591(2.10)  LDD2228  [7]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C297(2.25); C653(1.17)  LDD1702  [2]
 LDCM0625  F8 Ramos C202(1.05); C216(5.05); C653(1.74)  LDD2187  [11]
 LDCM0572  Fragment10 Ramos C202(0.57); C653(0.93)  LDD2189  [11]
 LDCM0573  Fragment11 Ramos C216(2.80)  LDD2190  [11]
 LDCM0574  Fragment12 Ramos C202(0.67); C653(0.69)  LDD2191  [11]
 LDCM0575  Fragment13 Ramos C202(0.87); C653(0.67)  LDD2192  [11]
 LDCM0576  Fragment14 Ramos C202(1.04); C216(0.59); C653(1.02)  LDD2193  [11]
 LDCM0579  Fragment20 Ramos C202(0.47); C653(0.48)  LDD2194  [11]
 LDCM0580  Fragment21 Ramos C202(0.91); C653(0.78)  LDD2195  [11]
 LDCM0582  Fragment23 Ramos C202(0.43); C653(0.64)  LDD2196  [11]
 LDCM0578  Fragment27 Ramos C202(0.85); C653(0.89)  LDD2197  [11]
 LDCM0586  Fragment28 Ramos C202(0.87); C216(1.94); C653(0.55)  LDD2198  [11]
 LDCM0588  Fragment30 Ramos C202(0.99); C653(0.88)  LDD2199  [11]
 LDCM0589  Fragment31 Ramos C202(1.10); C653(0.65)  LDD2200  [11]
 LDCM0590  Fragment32 Ramos C202(0.50)  LDD2201  [11]
 LDCM0468  Fragment33 Ramos C202(0.77); C653(1.10)  LDD2202  [11]
 LDCM0596  Fragment38 Ramos C202(1.01); C653(0.84)  LDD2203  [11]
 LDCM0566  Fragment4 Ramos C202(0.72); C216(0.98); C653(0.91)  LDD2184  [11]
 LDCM0427  Fragment51 PaTu 8988t C591(1.47)  LDD1306  [10]
 LDCM0610  Fragment52 Ramos C202(1.26); C653(0.54)  LDD2204  [11]
 LDCM0614  Fragment56 Ramos C202(1.62); C653(0.79)  LDD2205  [11]
 LDCM0569  Fragment7 Ramos C202(0.53); C216(1.26); C653(1.13)  LDD2186  [11]
 LDCM0571  Fragment9 Ramos C202(0.76); C653(0.56)  LDD2188  [11]
 LDCM0022  KB02 Ramos C202(0.61); C216(2.12); C653(1.80)  LDD2182  [11]
 LDCM0023  KB03 Jurkat C297(5.03)  LDD0209  [4]
 LDCM0024  KB05 COLO792 C216(3.87); C202(4.60)  LDD3310  [12]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Transcription factor
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Tumor protein p73 (TP73) P53 family O15350
Other
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
DNA mismatch repair protein Mlh1 (MLH1) DNA mismatch repair MutL/HexB family P40692

The Drug(s) Related To This Target

Investigative
Click To Hide/Show 1 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Adenosine 5'-[Gamma-thio]Triphosphate . DB02930

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
3 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
4 Covalent Inhibition by a Natural Product-Inspired Latent Electrophile. J Am Chem Soc. 2023 May 24;145(20):11097-11109. doi: 10.1021/jacs.3c00598. Epub 2023 May 15.
5 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
6 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
7 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
8 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
9 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
10 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
11 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578
12 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840