Details of the Target

General Information of Target

Target ID LDTP04488
Target Name CDK-activating kinase assembly factor MAT1 (MNAT1)
Gene Name MNAT1
Gene ID 4331
Synonyms
CAP35; MAT1; RNF66; CDK-activating kinase assembly factor MAT1; CDK7/cyclin-H assembly factor; Cyclin-G1-interacting protein; Menage a trois; RING finger protein 66; RING finger protein MAT1; p35; p36
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MDDQGCPRCKTTKYRNPSLKLMVNVCGHTLCESCVDLLFVRGAGNCPECGTPLRKSNFRV
QLFEDPTVDKEVEIRKKVLKIYNKREEDFPSLREYNDFLEEVEEIVFNLTNNVDLDNTKK
KMEIYQKENKDVIQKNKLKLTREQEELEEALEVERQENEQRRLFIQKEEQLQQILKRKNK
QAFLDELESSDLPVALLLAQHKDRSTQLEMQLEKPKPVKPVTFSTGIKMGQHISLAPIHK
LEEALYEYQPLQIETYGPHVPELEMLGRLGYLNHVRAASPQDLAGGYTSSLACHRALQDA
FSGLFWQPS
Target Bioclass
Other
Subcellular location
Nucleus
Function
Stabilizes the cyclin H-CDK7 complex to form a functional CDK-activating kinase (CAK) enzymatic complex. CAK activates the cyclin-associated kinases CDK1, CDK2, CDK4 and CDK6 by threonine phosphorylation. CAK complexed to the core-TFIIH basal transcription factor activates RNA polymerase II by serine phosphorylation of the repetitive C-terminal domain (CTD) of its large subunit (POLR2A), allowing its escape from the promoter and elongation of the transcripts. Involved in cell cycle control and in RNA transcription by RNA polymerase II.
Uniprot ID
P51948
Ensemble ID
ENST00000261245.9
HGNC ID
HGNC:7181
ChEMBL ID
CHEMBL3038473

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
JURKAT Insertion: p.L184FfsTer3 .
MFE319 SNV: p.P215T .
OVK18 Deletion: p.L184Ter .
SKMEL30 SNV: p.P47L .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 12 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
TH216
 Probe Info  		Y271(13.49)  LDD0259  [1]
STPyne
 Probe Info  		K119(0.59)  LDD2217  [2]
BTD
 Probe Info  		C293(0.87)  LDD2090  [3]
HHS-475
 Probe Info  		Y256(1.47)  LDD0264  [4]
IPM
 Probe Info  		C293(1.90)  LDD1702  [3]
DBIA
 Probe Info  		C46(1.53); C49(1.53)  LDD0080  [5]
m-APA
 Probe Info  		N.A.  LDD2232  [6]
IA-alkyne
 Probe Info  		N.A.  LDD2241  [7]
JW-RF-010
 Probe Info  		N.A.  LDD0026  [8]
NAIA_4
 Probe Info  		N.A.  LDD2226  [9]
TFBX
 Probe Info  		N.A.  LDD0027  [8]
NAIA_5
 Probe Info  		N.A.  LDD2223  [9]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0548  1-(4-(Benzo[d][1,3]dioxol-5-ylmethyl)piperazin-1-yl)-2-nitroethan-1-one MDA-MB-231 C293(0.43)  LDD2142  [3]
 LDCM0214  AC1 PaTu 8988t C46(1.06); C49(1.06)  LDD1093  [5]
 LDCM0215  AC10 HCT 116 C46(1.04); C49(1.04)  LDD0532  [5]
 LDCM0226  AC11 HCT 116 C46(0.92); C49(0.92)  LDD0543  [5]
 LDCM0237  AC12 HCT 116 C46(1.01); C49(1.01)  LDD0554  [5]
 LDCM0259  AC14 HCT 116 C46(0.85); C49(0.85)  LDD0576  [5]
 LDCM0263  AC143 HCT 116 C46(0.82); C49(0.82)  LDD0580  [5]
 LDCM0264  AC144 HCT 116 C46(0.87); C49(0.87)  LDD0581  [5]
 LDCM0265  AC145 HCT 116 C46(0.76); C49(0.76)  LDD0582  [5]
 LDCM0266  AC146 HCT 116 C46(0.84); C49(0.84)  LDD0583  [5]
 LDCM0267  AC147 HCT 116 C46(0.89); C49(0.89)  LDD0584  [5]
 LDCM0268  AC148 HCT 116 C46(0.88); C49(0.88)  LDD0585  [5]
 LDCM0269  AC149 HCT 116 C46(1.03); C49(1.03)  LDD0586  [5]
 LDCM0270  AC15 HCT 116 C46(0.92); C49(0.92)  LDD0587  [5]
 LDCM0271  AC150 HCT 116 C46(0.91); C49(0.91)  LDD0588  [5]
 LDCM0272  AC151 HCT 116 C46(0.96); C49(0.96)  LDD0589  [5]
 LDCM0273  AC152 HCT 116 C46(0.79); C49(0.79)  LDD0590  [5]
 LDCM0274  AC153 HCT 116 C46(0.87); C49(0.87)  LDD0591  [5]
 LDCM0621  AC154 HCT 116 C46(0.86); C49(0.86)  LDD2158  [5]
 LDCM0622  AC155 HCT 116 C46(1.03); C49(1.03)  LDD2159  [5]
 LDCM0623  AC156 HCT 116 C46(0.85); C49(0.85)  LDD2160  [5]
 LDCM0624  AC157 HCT 116 C46(0.77); C49(0.77)  LDD2161  [5]
 LDCM0276  AC17 HEK-293T C46(0.93); C49(0.93)  LDD0874  [5]
 LDCM0277  AC18 HEK-293T C46(1.04); C49(1.04)  LDD0875  [5]
 LDCM0278  AC19 HEK-293T C46(1.13); C49(1.13)  LDD0876  [5]
 LDCM0279  AC2 PaTu 8988t C46(0.79); C49(0.79)  LDD1158  [5]
 LDCM0280  AC20 HEK-293T C46(1.32); C49(1.32)  LDD0878  [5]
 LDCM0281  AC21 HEK-293T C46(0.99); C49(0.99)  LDD0879  [5]
 LDCM0282  AC22 HEK-293T C46(1.27); C49(1.27)  LDD0880  [5]
 LDCM0283  AC23 HEK-293T C46(1.08); C49(1.08)  LDD0881  [5]
 LDCM0284  AC24 HEK-293T C46(0.97); C49(0.97)  LDD0882  [5]
 LDCM0285  AC25 HEK-293T C46(0.97); C49(0.97)  LDD0883  [5]
 LDCM0286  AC26 HEK-293T C46(1.18); C49(1.18)  LDD0884  [5]
 LDCM0287  AC27 HEK-293T C46(0.86); C49(0.86)  LDD0885  [5]
 LDCM0288  AC28 HEK-293T C46(0.76); C49(0.76)  LDD0886  [5]
 LDCM0289  AC29 HEK-293T C46(1.39); C49(1.39)  LDD0887  [5]
 LDCM0290  AC3 PaTu 8988t C46(0.81); C49(0.81)  LDD1169  [5]
 LDCM0291  AC30 HEK-293T C46(1.12); C49(1.12)  LDD0889  [5]
 LDCM0292  AC31 HEK-293T C46(1.05); C49(1.05)  LDD0890  [5]
 LDCM0293  AC32 HEK-293T C46(0.84); C49(0.84)  LDD0891  [5]
 LDCM0294  AC33 HEK-293T C46(0.71); C49(0.71)  LDD0892  [5]
 LDCM0295  AC34 HEK-293T C46(0.84); C49(0.84)  LDD0893  [5]
 LDCM0296  AC35 HEK-293T C46(1.06); C49(1.06)  LDD0894  [5]
 LDCM0297  AC36 HEK-293T C46(1.18); C49(1.18)  LDD0895  [5]
 LDCM0298  AC37 HEK-293T C46(0.97); C49(0.97)  LDD0896  [5]
 LDCM0299  AC38 HEK-293T C46(1.21); C49(1.21)  LDD0897  [5]
 LDCM0300  AC39 HEK-293T C46(1.12); C49(1.12)  LDD0898  [5]
 LDCM0301  AC4 PaTu 8988t C46(0.79); C49(0.79)  LDD1180  [5]
 LDCM0302  AC40 HEK-293T C46(1.50); C49(1.50)  LDD0900  [5]
 LDCM0303  AC41 HEK-293T C46(1.35); C49(1.35)  LDD0901  [5]
 LDCM0304  AC42 HEK-293T C46(1.10); C49(1.10)  LDD0902  [5]
 LDCM0305  AC43 HEK-293T C46(1.16); C49(1.16)  LDD0903  [5]
 LDCM0306  AC44 HEK-293T C46(1.14); C49(1.14)  LDD0904  [5]
 LDCM0307  AC45 HEK-293T C46(1.05); C49(1.05)  LDD0905  [5]
 LDCM0308  AC46 HEK-293T C46(1.18); C49(1.18)  LDD0906  [5]
 LDCM0309  AC47 HEK-293T C46(1.62); C49(1.62)  LDD0907  [5]
 LDCM0310  AC48 HEK-293T C46(1.41); C49(1.41)  LDD0908  [5]
 LDCM0311  AC49 HEK-293T C46(1.47); C49(1.47)  LDD0909  [5]
 LDCM0312  AC5 PaTu 8988t C46(0.80); C49(0.80)  LDD1191  [5]
 LDCM0313  AC50 HEK-293T C46(0.94); C49(0.94)  LDD0911  [5]
 LDCM0314  AC51 HEK-293T C46(0.97); C49(0.97)  LDD0912  [5]
 LDCM0315  AC52 HEK-293T C46(1.11); C49(1.11)  LDD0913  [5]
 LDCM0316  AC53 HEK-293T C46(1.03); C49(1.03)  LDD0914  [5]
 LDCM0317  AC54 HEK-293T C46(1.02); C49(1.02)  LDD0915  [5]
 LDCM0318  AC55 HEK-293T C46(1.16); C49(1.16)  LDD0916  [5]
 LDCM0319  AC56 HEK-293T C46(1.19); C49(1.19)  LDD0917  [5]
 LDCM0320  AC57 HCT 116 C46(0.72); C49(0.72)  LDD0637  [5]
 LDCM0321  AC58 HCT 116 C46(0.62); C49(0.62)  LDD0638  [5]
 LDCM0322  AC59 HCT 116 C46(0.75); C49(0.75)  LDD0639  [5]
 LDCM0323  AC6 HCT 116 C46(0.75); C49(0.75)  LDD0640  [5]
 LDCM0324  AC60 HCT 116 C46(0.57); C49(0.57)  LDD0641  [5]
 LDCM0325  AC61 HCT 116 C46(0.52); C49(0.52)  LDD0642  [5]
 LDCM0326  AC62 HCT 116 C46(0.63); C49(0.63)  LDD0643  [5]
 LDCM0327  AC63 HCT 116 C46(0.63); C49(0.63)  LDD0644  [5]
 LDCM0328  AC64 HCT 116 C46(0.61); C49(0.61)  LDD0645  [5]
 LDCM0329  AC65 HCT 116 C46(0.59); C49(0.59)  LDD0646  [5]
 LDCM0330  AC66 HCT 116 C46(0.57); C49(0.57)  LDD0647  [5]
 LDCM0331  AC67 HCT 116 C46(0.35); C49(0.35)  LDD0648  [5]
 LDCM0332  AC68 PaTu 8988t C46(1.13); C49(1.13)  LDD1211  [5]
 LDCM0333  AC69 PaTu 8988t C46(0.87); C49(0.87)  LDD1212  [5]
 LDCM0334  AC7 HCT 116 C46(0.82); C49(0.82)  LDD0651  [5]
 LDCM0335  AC70 PaTu 8988t C46(0.71); C49(0.71)  LDD1214  [5]
 LDCM0336  AC71 PaTu 8988t C46(0.81); C49(0.81)  LDD1215  [5]
 LDCM0337  AC72 PaTu 8988t C46(0.83); C49(0.83)  LDD1216  [5]
 LDCM0338  AC73 PaTu 8988t C46(0.76); C49(0.76)  LDD1217  [5]
 LDCM0339  AC74 PaTu 8988t C46(0.78); C49(0.78)  LDD1218  [5]
 LDCM0340  AC75 PaTu 8988t C46(0.76); C49(0.76)  LDD1219  [5]
 LDCM0341  AC76 PaTu 8988t C46(1.06); C49(1.06)  LDD1220  [5]
 LDCM0342  AC77 PaTu 8988t C46(0.88); C49(0.88)  LDD1221  [5]
 LDCM0343  AC78 PaTu 8988t C46(0.76); C49(0.76)  LDD1222  [5]
 LDCM0344  AC79 PaTu 8988t C46(0.83); C49(0.83)  LDD1223  [5]
 LDCM0345  AC8 HCT 116 C46(0.85); C49(0.85)  LDD0662  [5]
 LDCM0346  AC80 PaTu 8988t C46(0.95); C49(0.95)  LDD1225  [5]
 LDCM0347  AC81 PaTu 8988t C46(0.76); C49(0.76)  LDD1226  [5]
 LDCM0348  AC82 PaTu 8988t C46(1.44); C49(1.44)  LDD1227  [5]
 LDCM0349  AC83 HCT 116 C46(0.86); C49(0.86)  LDD0666  [5]
 LDCM0350  AC84 HCT 116 C46(0.81); C49(0.81)  LDD0667  [5]
 LDCM0351  AC85 HCT 116 C46(0.88); C49(0.88)  LDD0668  [5]
 LDCM0352  AC86 HCT 116 C46(1.07); C49(1.07)  LDD0669  [5]
 LDCM0353  AC87 HCT 116 C46(0.89); C49(0.89)  LDD0670  [5]
 LDCM0354  AC88 HCT 116 C46(0.96); C49(0.96)  LDD0671  [5]
 LDCM0355  AC89 HCT 116 C46(1.17); C49(1.17)  LDD0672  [5]
 LDCM0357  AC90 HCT 116 C46(1.08); C49(1.08)  LDD0674  [5]
 LDCM0358  AC91 HCT 116 C46(1.06); C49(1.06)  LDD0675  [5]
 LDCM0359  AC92 HCT 116 C46(1.13); C49(1.13)  LDD0676  [5]
 LDCM0360  AC93 HCT 116 C46(1.02); C49(1.02)  LDD0677  [5]
 LDCM0361  AC94 HCT 116 C46(0.88); C49(0.88)  LDD0678  [5]
 LDCM0362  AC95 HCT 116 C46(0.90); C49(0.90)  LDD0679  [5]
 LDCM0363  AC96 HCT 116 C46(0.94); C49(0.94)  LDD0680  [5]
 LDCM0364  AC97 HCT 116 C46(1.02); C49(1.02)  LDD0681  [5]
 LDCM0520  AKOS000195272 MDA-MB-231 C293(1.28)  LDD2113  [3]
 LDCM0248  AKOS034007472 HCT 116 C46(0.97); C49(0.97)  LDD0565  [5]
 LDCM0356  AKOS034007680 HCT 116 C46(0.87); C49(0.87)  LDD0673  [5]
 LDCM0275  AKOS034007705 HCT 116 C46(0.78); C49(0.78)  LDD0592  [5]
 LDCM0498  BS-3668 MDA-MB-231 C293(0.61)  LDD2091  [3]
 LDCM0367  CL1 HEK-293T C46(0.82); C49(0.82)  LDD0965  [5]
 LDCM0368  CL10 HEK-293T C46(0.70); C49(0.70)  LDD0966  [5]
 LDCM0369  CL100 PaTu 8988t C46(0.73); C49(0.73)  LDD1248  [5]
 LDCM0370  CL101 HCT 116 C46(1.01); C49(1.01)  LDD0687  [5]
 LDCM0371  CL102 HCT 116 C46(1.06); C49(1.06)  LDD0688  [5]
 LDCM0372  CL103 HCT 116 C46(1.14); C49(1.14)  LDD0689  [5]
 LDCM0373  CL104 HCT 116 C46(0.93); C49(0.93)  LDD0690  [5]
 LDCM0374  CL105 HEK-293T C46(1.25); C49(1.25)  LDD0972  [5]
 LDCM0375  CL106 HEK-293T C46(1.04); C49(1.04)  LDD0973  [5]
 LDCM0376  CL107 HEK-293T C46(1.40); C49(1.40)  LDD0974  [5]
 LDCM0377  CL108 HEK-293T C46(1.22); C49(1.22)  LDD0975  [5]
 LDCM0378  CL109 HEK-293T C46(1.04); C49(1.04)  LDD0976  [5]
 LDCM0379  CL11 HEK-293T C46(0.80); C49(0.80)  LDD0977  [5]
 LDCM0380  CL110 HEK-293T C46(0.84); C49(0.84)  LDD0978  [5]
 LDCM0381  CL111 HEK-293T C46(1.03); C49(1.03)  LDD0979  [5]
 LDCM0382  CL112 HEK-293T C46(0.74); C49(0.74)  LDD0980  [5]
 LDCM0383  CL113 HEK-293T C46(0.98); C49(0.98)  LDD0981  [5]
 LDCM0384  CL114 HEK-293T C46(0.78); C49(0.78)  LDD0982  [5]
 LDCM0385  CL115 HEK-293T C46(0.72); C49(0.72)  LDD0983  [5]
 LDCM0386  CL116 HEK-293T C46(0.72); C49(0.72)  LDD0984  [5]
 LDCM0387  CL117 HEK-293T C46(1.27); C49(1.27)  LDD0985  [5]
 LDCM0388  CL118 HEK-293T C46(1.46); C49(1.46)  LDD0986  [5]
 LDCM0389  CL119 HEK-293T C46(1.33); C49(1.33)  LDD0987  [5]
 LDCM0390  CL12 HEK-293T C46(0.79); C49(0.79)  LDD0988  [5]
 LDCM0391  CL120 HEK-293T C46(1.15); C49(1.15)  LDD0989  [5]
 LDCM0392  CL121 HEK-293T C46(1.08); C49(1.08)  LDD0990  [5]
 LDCM0393  CL122 HEK-293T C46(0.69); C49(0.69)  LDD0991  [5]
 LDCM0394  CL123 HEK-293T C46(0.91); C49(0.91)  LDD0992  [5]
 LDCM0395  CL124 HEK-293T C46(1.03); C49(1.03)  LDD0993  [5]
 LDCM0396  CL125 HCT 116 C46(0.66); C49(0.66)  LDD0713  [5]
 LDCM0397  CL126 HCT 116 C46(0.79); C49(0.79)  LDD0714  [5]
 LDCM0398  CL127 HCT 116 C46(0.92); C49(0.92)  LDD0715  [5]
 LDCM0399  CL128 HCT 116 C46(1.02); C49(1.02)  LDD0716  [5]
 LDCM0400  CL13 HEK-293T C46(0.78); C49(0.78)  LDD0998  [5]
 LDCM0401  CL14 HEK-293T C46(0.74); C49(0.74)  LDD0999  [5]
 LDCM0402  CL15 HEK-293T C46(0.65); C49(0.65)  LDD1000  [5]
 LDCM0403  CL16 HEK-293T C293(1.05)  LDD1607  [10]
 LDCM0404  CL17 HEK-293T C293(1.05)  LDD1608  [10]
 LDCM0406  CL19 HEK-293T C293(1.02)  LDD1610  [10]
 LDCM0407  CL2 HEK-293T C46(0.91); C49(0.91)  LDD1005  [5]
 LDCM0408  CL20 HEK-293T C293(1.01)  LDD1612  [10]
 LDCM0409  CL21 HEK-293T C293(1.27)  LDD1613  [10]
 LDCM0411  CL23 HEK-293T C293(1.06)  LDD1615  [10]
 LDCM0412  CL24 HEK-293T C293(1.10)  LDD1616  [10]
 LDCM0414  CL26 HEK-293T C293(1.10)  LDD1618  [10]
 LDCM0416  CL28 HEK-293T C293(0.92)  LDD1620  [10]
 LDCM0417  CL29 HEK-293T C293(1.35)  LDD1621  [10]
 LDCM0418  CL3 HEK-293T C46(1.00); C49(1.00)  LDD1016  [5]
 LDCM0420  CL31 HEK-293T C293(1.16)  LDD1624  [10]
 LDCM0421  CL32 HEK-293T C293(0.92)  LDD1625  [10]
 LDCM0422  CL33 HEK-293T C293(1.04)  LDD1626  [10]
 LDCM0424  CL35 HEK-293T C293(0.91)  LDD1628  [10]
 LDCM0425  CL36 HEK-293T C293(0.89)  LDD1629  [10]
 LDCM0429  CL4 HEK-293T C46(0.74); C49(0.74)  LDD1027  [5]
 LDCM0430  CL40 HEK-293T C293(1.09)  LDD1634  [10]
 LDCM0431  CL41 HEK-293T C293(1.14)  LDD1635  [10]
 LDCM0433  CL43 HEK-293T C293(1.27)  LDD1637  [10]
 LDCM0434  CL44 HEK-293T C293(1.03)  LDD1638  [10]
 LDCM0435  CL45 HEK-293T C293(1.29)  LDD1639  [10]
 LDCM0436  CL46 HCT 116 C46(0.73); C49(0.73)  LDD0753  [5]
 LDCM0437  CL47 HCT 116 C46(0.98); C49(0.98)  LDD0754  [5]
 LDCM0438  CL48 HCT 116 C46(0.84); C49(0.84)  LDD0755  [5]
 LDCM0439  CL49 HCT 116 C46(0.93); C49(0.93)  LDD0756  [5]
 LDCM0440  CL5 HEK-293T C46(1.03); C49(1.03)  LDD1038  [5]
 LDCM0441  CL50 HCT 116 C46(0.77); C49(0.77)  LDD0758  [5]
 LDCM0442  CL51 HCT 116 C46(0.89); C49(0.89)  LDD0759  [5]
 LDCM0443  CL52 HCT 116 C46(0.80); C49(0.80)  LDD0760  [5]
 LDCM0444  CL53 HCT 116 C46(0.54); C49(0.54)  LDD0761  [5]
 LDCM0445  CL54 HCT 116 C46(0.94); C49(0.94)  LDD0762  [5]
 LDCM0446  CL55 HCT 116 C46(0.96); C49(0.96)  LDD0763  [5]
 LDCM0447  CL56 HCT 116 C46(1.04); C49(1.04)  LDD0764  [5]
 LDCM0448  CL57 HCT 116 C46(0.86); C49(0.86)  LDD0765  [5]
 LDCM0449  CL58 HCT 116 C46(0.91); C49(0.91)  LDD0766  [5]
 LDCM0450  CL59 HCT 116 C46(1.06); C49(1.06)  LDD0767  [5]
 LDCM0451  CL6 HEK-293T C46(0.98); C49(0.98)  LDD1049  [5]
 LDCM0452  CL60 HCT 116 C46(1.15); C49(1.15)  LDD0769  [5]
 LDCM0454  CL62 HEK-293T C293(1.09)  LDD1657  [10]
 LDCM0456  CL64 HEK-293T C293(1.04)  LDD1659  [10]
 LDCM0457  CL65 HEK-293T C293(1.09)  LDD1660  [10]
 LDCM0459  CL67 HEK-293T C293(1.13)  LDD1662  [10]
 LDCM0460  CL68 HEK-293T C293(1.04)  LDD1663  [10]
 LDCM0461  CL69 HEK-293T C293(1.04)  LDD1664  [10]
 LDCM0462  CL7 HEK-293T C46(0.78); C49(0.78)  LDD1060  [5]
 LDCM0464  CL71 HEK-293T C293(1.25)  LDD1667  [10]
 LDCM0465  CL72 HEK-293T C293(1.48)  LDD1668  [10]
 LDCM0467  CL74 HEK-293T C293(0.95)  LDD1670  [10]
 LDCM0469  CL76 PaTu 8988t C46(1.67); C49(1.67)  LDD1348  [5]
 LDCM0470  CL77 PaTu 8988t C46(1.39); C49(1.39)  LDD1349  [5]
 LDCM0471  CL78 PaTu 8988t C46(1.55); C49(1.55)  LDD1350  [5]
 LDCM0472  CL79 PaTu 8988t C46(1.48); C49(1.48)  LDD1351  [5]
 LDCM0473  CL8 HEK-293T C46(1.31); C49(0.75)  LDD1071  [5]
 LDCM0474  CL80 PaTu 8988t C46(1.14); C49(1.14)  LDD1353  [5]
 LDCM0475  CL81 PaTu 8988t C46(1.23); C49(1.23)  LDD1354  [5]
 LDCM0476  CL82 PaTu 8988t C46(2.07); C49(2.07)  LDD1355  [5]
 LDCM0477  CL83 PaTu 8988t C46(0.94); C49(0.94)  LDD1356  [5]
 LDCM0478  CL84 PaTu 8988t C46(1.10); C49(1.10)  LDD1357  [5]
 LDCM0479  CL85 PaTu 8988t C46(0.92); C49(0.92)  LDD1358  [5]
 LDCM0480  CL86 PaTu 8988t C46(1.12); C49(1.12)  LDD1359  [5]
 LDCM0481  CL87 PaTu 8988t C46(0.89); C49(0.89)  LDD1360  [5]
 LDCM0482  CL88 PaTu 8988t C46(1.27); C49(1.27)  LDD1361  [5]
 LDCM0483  CL89 PaTu 8988t C46(1.40); C49(1.40)  LDD1362  [5]
 LDCM0484  CL9 HEK-293T C46(1.19); C49(0.86)  LDD1082  [5]
 LDCM0485  CL90 PaTu 8988t C46(1.02); C49(1.02)  LDD1364  [5]
 LDCM0486  CL91 PaTu 8988t C46(0.72); C49(0.72)  LDD1365  [5]
 LDCM0487  CL92 PaTu 8988t C46(0.80); C49(0.80)  LDD1366  [5]
 LDCM0488  CL93 PaTu 8988t C46(0.99); C49(0.99)  LDD1367  [5]
 LDCM0489  CL94 PaTu 8988t C46(0.78); C49(0.78)  LDD1368  [5]
 LDCM0490  CL95 PaTu 8988t C46(0.65); C49(0.65)  LDD1369  [5]
 LDCM0491  CL96 PaTu 8988t C46(0.82); C49(0.82)  LDD1370  [5]
 LDCM0492  CL97 PaTu 8988t C46(0.75); C49(0.75)  LDD1371  [5]
 LDCM0493  CL98 PaTu 8988t C46(0.69); C49(0.69)  LDD1372  [5]
 LDCM0494  CL99 PaTu 8988t C46(0.68); C49(0.68)  LDD1373  [5]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C293(1.90)  LDD1702  [3]
 LDCM0427  Fragment51 HEK-293T C293(0.97)  LDD1631  [10]
 LDCM0116  HHS-0101 DM93 Y256(1.47)  LDD0264  [4]
 LDCM0119  HHS-0401 DM93 Y256(4.28)  LDD0267  [4]
 LDCM0022  KB02 HCT 116 C46(1.53); C49(1.53)  LDD0080  [5]
 LDCM0023  KB03 HCT 116 C46(2.14); C49(2.14)  LDD0081  [5]
 LDCM0024  KB05 HCT 116 C46(2.14); C49(2.14)  LDD0082  [5]
 LDCM0497  Nucleophilic fragment 11b MDA-MB-231 C293(0.87)  LDD2090  [3]
 LDCM0505  Nucleophilic fragment 15b MDA-MB-231 C293(1.00)  LDD2098  [3]
 LDCM0506  Nucleophilic fragment 16a MDA-MB-231 C293(0.93)  LDD2099  [3]
 LDCM0513  Nucleophilic fragment 19b MDA-MB-231 C293(0.48)  LDD2106  [3]
 LDCM0514  Nucleophilic fragment 20a MDA-MB-231 C293(0.64)  LDD2107  [3]
 LDCM0515  Nucleophilic fragment 20b MDA-MB-231 C293(0.54)  LDD2108  [3]
 LDCM0517  Nucleophilic fragment 21b MDA-MB-231 C293(0.96)  LDD2110  [3]
 LDCM0522  Nucleophilic fragment 24a MDA-MB-231 C293(0.69)  LDD2115  [3]
 LDCM0527  Nucleophilic fragment 26b MDA-MB-231 C293(1.06)  LDD2120  [3]
 LDCM0529  Nucleophilic fragment 27b MDA-MB-231 C293(0.24)  LDD2122  [3]
 LDCM0531  Nucleophilic fragment 28b MDA-MB-231 C293(0.21)  LDD2124  [3]
 LDCM0532  Nucleophilic fragment 29a MDA-MB-231 C293(0.89)  LDD2125  [3]
 LDCM0540  Nucleophilic fragment 35 MDA-MB-231 C293(0.82)  LDD2133  [3]
 LDCM0541  Nucleophilic fragment 36 MDA-MB-231 C293(0.58)  LDD2134  [3]
 LDCM0542  Nucleophilic fragment 37 MDA-MB-231 C293(1.08)  LDD2135  [3]
 LDCM0544  Nucleophilic fragment 39 MDA-MB-231 C293(0.82)  LDD2137  [3]
 LDCM0546  Nucleophilic fragment 40 MDA-MB-231 C293(0.78)  LDD2140  [3]
 LDCM0547  Nucleophilic fragment 41 MDA-MB-231 C293(0.53)  LDD2141  [3]
 LDCM0549  Nucleophilic fragment 43 MDA-MB-231 C293(0.99)  LDD2143  [3]
 LDCM0550  Nucleophilic fragment 5a MDA-MB-231 C293(2.11)  LDD2144  [3]
 LDCM0551  Nucleophilic fragment 5b MDA-MB-231 C293(0.79)  LDD2145  [3]
 LDCM0552  Nucleophilic fragment 6a MDA-MB-231 C293(0.93)  LDD2146  [3]
 LDCM0554  Nucleophilic fragment 7a MDA-MB-231 C293(0.66)  LDD2148  [3]
 LDCM0556  Nucleophilic fragment 8a MDA-MB-231 C293(0.59)  LDD2150  [3]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Transporter and channel
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Huntingtin (HTT) Huntingtin family P42858
Other
Click To Hide/Show 3 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Golgin subfamily A member 2 (GOLGA2) GOLGA2 family Q08379
RING finger protein 11 (RNF11) . Q9Y3C5
TAR DNA-binding protein 43 (TARDBP) . Q13148

References

1 Chemoproteomic profiling of kinases in live cells using electrophilic sulfonyl triazole probes. Chem Sci. 2021 Jan 21;12(9):3295-3307. doi: 10.1039/d0sc06623k.
2 Global profiling of lysine reactivity and ligandability in the human proteome. Nat Chem. 2017 Dec;9(12):1181-1190. doi: 10.1038/nchem.2826. Epub 2017 Jul 31.
3 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
4 Discovery of a Cell-Active SuTEx Ligand of Prostaglandin Reductase 2. Chembiochem. 2021 Jun 15;22(12):2134-2139. doi: 10.1002/cbic.202000879. Epub 2021 Apr 29.
5 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
6 Global profiling of functional histidines in live cells using small-molecule photosensitizer and chemical probe relay labelling. Nat Chem. 2024 Jun 4. doi: 10.1038/s41557-024-01545-6. Online ahead of print.
Mass spectrometry data entry: PXD042377
7 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
8 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
9 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
10 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402