Details of the Target

General Information of Target

Target ID LDTP04228
Target Name Nuclear receptor subfamily 2 group C member 2 (NR2C2)
Gene Name NR2C2
Gene ID 7182
Synonyms
TAK1; TR4; Nuclear receptor subfamily 2 group C member 2; Orphan nuclear receptor TAK1; Orphan nuclear receptor TR4; Testicular receptor 4
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MTSPSPRIQIISTDSAVASPQRIQIVTDQQTGQKIQIVTAVDASGSPKQQFILTSPDGAG
TGKVILASPETSSAKQLIFTTSDNLVPGRIQIVTDSASVERLLGKTDVQRPQVVEYCVVC
GDKASGRHYGAVSCEGCKGFFKRSVRKNLTYSCRSNQDCIINKHHRNRCQFCRLKKCLEM
GMKMESVQSERKPFDVQREKPSNCAASTEKIYIRKDLRSPLIATPTFVADKDGARQTGLL
DPGMLVNIQQPLIREDGTVLLATDSKAETSQGALGTLANVVTSLANLSESLNNGDTSEIQ
PEDQSASEITRAFDTLAKALNTTDSSSSPSLADGIDTSGGGSIHVISRDQSTPIIEVEGP
LLSDTHVTFKLTMPSPMPEYLNVHYICESASRLLFLSMHWARSIPAFQALGQDCNTSLVR
ACWNELFTLGLAQCAQVMSLSTILAAIVNHLQNSIQEDKLSGDRIKQVMEHIWKLQEFCN
SMAKLDIDGYEYAYLKAIVLFSPDHPGLTSTSQIEKFQEKAQMELQDYVQKTYSEDTYRL
ARILVRLPALRLMSSNITEELFFTGLIGNVSIDSIIPYILKMETAEYNGQITGASL
Target Bioclass
Transcription factor
Family
Nuclear hormone receptor family, NR2 subfamily
Subcellular location
Nucleus
Function
Orphan nuclear receptor that can act as a repressor or activator of transcription. An important repressor of nuclear receptor signaling pathways such as retinoic acid receptor, retinoid X, vitamin D3 receptor, thyroid hormone receptor and estrogen receptor pathways. May regulate gene expression during the late phase of spermatogenesis. Together with NR2C1, forms the core of the DRED (direct repeat erythroid-definitive) complex that represses embryonic and fetal globin transcription including that of GATA1. Binds to hormone response elements (HREs) consisting of two 5'-AGGTCA-3' half site direct repeat consensus sequences. Plays a fundamental role in early embryonic development and embryonic stem cells. Required for normal spermatogenesis and cerebellum development. Appears to be important for neurodevelopmentally regulated behavior. Activates transcriptional activity of LHCG. Antagonist of PPARA-mediated transactivation.
Uniprot ID
P49116
Ensemble ID
ENST00000323373.10
HGNC ID
HGNC:7972
ChEMBL ID
CHEMBL5716

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
CCK81 Deletion: p.F563LfsTer10 DBIA    Probe Info 
HUH28 SNV: p.P376A DBIA    Probe Info 
IM95 Deletion: p.F563LfsTer10 DBIA    Probe Info 
NALM6 SNV: p.V99G; p.G294S DBIA    Probe Info 
SNU1 SNV: p.T592A DBIA    Probe Info 

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 13 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		15.00  LDD0402  [1]
BTD
 Probe Info  		C204(0.91)  LDD2096  [2]
AHL-Pu-1
 Probe Info  		C204(4.60)  LDD0171  [3]
DBIA
 Probe Info  		C479(21.50)  LDD0204  [4]
4-Iodoacetamidophenylacetylene
 Probe Info  		C479(0.00); C204(0.00)  LDD0038  [5]
IA-alkyne
 Probe Info  		N.A.  LDD0036  [5]
Lodoacetamide azide
 Probe Info  		C204(0.00); C159(0.00)  LDD0037  [5]
TFBX
 Probe Info  		N.A.  LDD0027  [6]
IPM
 Probe Info  		N.A.  LDD0005  [7]
VSF
 Probe Info  		N.A.  LDD0007  [7]
Acrolein
 Probe Info  		N.A.  LDD0217  [8]
AOyne
 Probe Info  		14.90  LDD0443  [9]
NAIA_5
 Probe Info  		N.A.  LDD2223  [10]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0026  4SU-RNA+native RNA DM93 C204(4.60)  LDD0171  [3]
 LDCM0214  AC1 HEK-293T C204(1.09); C153(0.88); C159(0.91); C414(0.96)  LDD1507  [11]
 LDCM0215  AC10 HEK-293T C204(0.96); C159(0.92); C479(0.87); C414(0.71)  LDD1508  [11]
 LDCM0226  AC11 HEK-293T C204(1.22); C153(1.06); C159(1.00); C479(1.02)  LDD1509  [11]
 LDCM0237  AC12 HEK-293T C204(0.82); C153(0.94); C159(1.00); C479(0.92)  LDD1510  [11]
 LDCM0259  AC14 HEK-293T C204(0.87); C153(1.06); C159(1.03); C479(0.84)  LDD1512  [11]
 LDCM0270  AC15 HEK-293T C204(0.84); C153(1.04); C159(1.00); C479(1.00)  LDD1513  [11]
 LDCM0276  AC17 HEK-293T C204(1.08); C153(1.00); C159(0.99); C414(1.11)  LDD1515  [11]
 LDCM0277  AC18 HEK-293T C204(0.99); C159(0.94); C479(0.81); C414(0.74)  LDD1516  [11]
 LDCM0278  AC19 HEK-293T C204(1.27); C153(1.45); C159(1.13); C479(0.94)  LDD1517  [11]
 LDCM0279  AC2 HEK-293T C204(0.94); C159(0.98); C479(0.75); C414(0.73)  LDD1518  [11]
 LDCM0280  AC20 HEK-293T C204(0.78); C153(0.96); C159(1.07); C479(0.98)  LDD1519  [11]
 LDCM0281  AC21 HEK-293T C204(0.95); C153(0.97); C159(0.97); C414(0.98)  LDD1520  [11]
 LDCM0282  AC22 HEK-293T C204(0.91); C153(0.95); C159(1.05); C479(0.98)  LDD1521  [11]
 LDCM0283  AC23 HEK-293T C204(0.86); C153(0.99); C159(1.03); C479(1.03)  LDD1522  [11]
 LDCM0284  AC24 HEK-293T C204(0.88); C153(0.95); C159(0.90); C479(1.00)  LDD1523  [11]
 LDCM0285  AC25 HEK-293T C204(1.09); C153(0.97); C159(0.95); C414(0.89)  LDD1524  [11]
 LDCM0286  AC26 HEK-293T C204(1.01); C159(0.91); C479(0.88); C414(0.83)  LDD1525  [11]
 LDCM0287  AC27 HEK-293T C204(1.20); C153(0.97); C159(0.99); C479(0.99)  LDD1526  [11]
 LDCM0288  AC28 HEK-293T C204(0.82); C153(1.01); C159(0.95); C479(0.89)  LDD1527  [11]
 LDCM0289  AC29 HEK-293T C204(0.95); C153(1.02); C159(0.99); C414(0.90)  LDD1528  [11]
 LDCM0290  AC3 HEK-293T C204(1.24); C153(1.02); C159(1.00); C479(1.02)  LDD1529  [11]
 LDCM0291  AC30 HEK-293T C204(1.00); C153(1.00); C159(1.06); C479(1.06)  LDD1530  [11]
 LDCM0292  AC31 HEK-293T C204(0.94); C153(1.06); C159(1.02); C479(0.92)  LDD1531  [11]
 LDCM0293  AC32 HEK-293T C204(0.94); C153(1.01); C159(1.02); C479(0.88)  LDD1532  [11]
 LDCM0294  AC33 HEK-293T C204(1.07); C153(0.89); C159(0.92); C414(0.98)  LDD1533  [11]
 LDCM0295  AC34 HEK-293T C204(0.94); C159(0.99); C479(0.79); C414(0.78)  LDD1534  [11]
 LDCM0296  AC35 HEK-293T C204(1.20); C153(1.01); C159(1.00); C479(0.96)  LDD1535  [11]
 LDCM0297  AC36 HEK-293T C204(0.78); C153(1.05); C159(1.06); C479(0.97)  LDD1536  [11]
 LDCM0298  AC37 HEK-293T C204(0.90); C153(0.96); C159(1.03); C414(1.01)  LDD1537  [11]
 LDCM0299  AC38 HEK-293T C204(0.95); C153(0.97); C159(1.12); C479(0.95)  LDD1538  [11]
 LDCM0300  AC39 HEK-293T C204(0.85); C153(1.01); C159(1.05); C479(0.92)  LDD1539  [11]
 LDCM0301  AC4 HEK-293T C204(0.94); C153(1.03); C159(0.99); C479(0.97)  LDD1540  [11]
 LDCM0302  AC40 HEK-293T C204(0.86); C153(1.01); C159(1.05); C479(0.92)  LDD1541  [11]
 LDCM0303  AC41 HEK-293T C204(1.05); C153(0.96); C159(0.92); C414(1.15)  LDD1542  [11]
 LDCM0304  AC42 HEK-293T C204(0.95); C159(0.90); C479(0.97); C414(0.84)  LDD1543  [11]
 LDCM0305  AC43 HEK-293T C204(1.20); C153(0.97); C159(0.97); C479(0.90)  LDD1544  [11]
 LDCM0306  AC44 HEK-293T C204(0.88); C153(1.02); C159(1.01); C479(0.97)  LDD1545  [11]
 LDCM0307  AC45 HEK-293T C204(0.92); C153(0.98); C159(1.00); C414(0.98)  LDD1546  [11]
 LDCM0308  AC46 HEK-293T C204(0.92); C153(0.94); C159(1.07); C479(0.83)  LDD1547  [11]
 LDCM0309  AC47 HEK-293T C204(0.92); C153(1.03); C159(1.10); C479(0.97)  LDD1548  [11]
 LDCM0310  AC48 HEK-293T C204(0.88); C153(0.97); C159(1.03); C479(1.00)  LDD1549  [11]
 LDCM0311  AC49 HEK-293T C204(1.04); C153(0.94); C159(0.98); C414(1.15)  LDD1550  [11]
 LDCM0312  AC5 HEK-293T C204(0.93); C153(1.03); C159(1.06); C414(0.90)  LDD1551  [11]
 LDCM0313  AC50 HEK-293T C204(0.96); C159(0.91); C479(0.84); C414(0.79)  LDD1552  [11]
 LDCM0314  AC51 HEK-293T C204(1.20); C153(0.98); C159(1.01); C479(1.00)  LDD1553  [11]
 LDCM0315  AC52 HEK-293T C204(0.89); C153(0.86); C159(1.03); C479(1.03)  LDD1554  [11]
 LDCM0316  AC53 HEK-293T C204(0.95); C153(1.03); C159(1.03); C414(1.13)  LDD1555  [11]
 LDCM0317  AC54 HEK-293T C204(0.97); C153(1.03); C159(1.12); C479(0.99)  LDD1556  [11]
 LDCM0318  AC55 HEK-293T C204(0.94); C153(1.05); C159(1.08); C479(1.00)  LDD1557  [11]
 LDCM0319  AC56 HEK-293T C204(0.93); C153(0.99); C159(1.09); C479(0.92)  LDD1558  [11]
 LDCM0320  AC57 HEK-293T C204(1.07); C153(0.92); C159(0.89); C414(1.09)  LDD1559  [11]
 LDCM0321  AC58 HEK-293T C204(0.90); C159(0.99); C479(0.86); C414(1.02)  LDD1560  [11]
 LDCM0322  AC59 HEK-293T C204(1.14); C153(0.96); C159(1.00); C479(1.00)  LDD1561  [11]
 LDCM0323  AC6 HEK-293T C204(0.99); C153(1.01); C159(1.03); C479(0.88)  LDD1562  [11]
 LDCM0324  AC60 HEK-293T C204(0.79); C153(0.89); C159(0.96); C479(0.92)  LDD1563  [11]
 LDCM0325  AC61 HEK-293T C204(0.90); C153(0.96); C159(0.94); C414(1.04)  LDD1564  [11]
 LDCM0326  AC62 HEK-293T C204(0.93); C153(0.92); C159(1.02); C479(0.95)  LDD1565  [11]
 LDCM0327  AC63 HEK-293T C204(0.82); C153(0.93); C159(0.99); C479(1.01)  LDD1566  [11]
 LDCM0328  AC64 HEK-293T C204(0.92); C153(1.05); C159(1.08); C479(0.95)  LDD1567  [11]
 LDCM0334  AC7 HEK-293T C204(0.86); C153(1.03); C159(1.09); C479(1.05)  LDD1568  [11]
 LDCM0345  AC8 HEK-293T C204(0.91); C153(0.89); C159(1.11); C479(0.88)  LDD1569  [11]
 LDCM0248  AKOS034007472 HEK-293T C204(0.91); C153(1.02); C159(0.98); C414(0.96)  LDD1511  [11]
 LDCM0356  AKOS034007680 HEK-293T C204(1.06); C153(0.97); C159(0.96); C414(1.16)  LDD1570  [11]
 LDCM0275  AKOS034007705 HEK-293T C204(0.93); C153(0.98); C159(1.07); C479(0.96)  LDD1514  [11]
 LDCM0156  Aniline NCI-H1299 12.28  LDD0403  [1]
 LDCM0102  BDHI 8 Jurkat C479(21.50)  LDD0204  [4]
 LDCM0108  Chloroacetamide HeLa N.A.  LDD0222  [8]
 LDCM0632  CL-Sc Hep-G2 C204(0.32)  LDD2227  [10]
 LDCM0367  CL1 HEK-293T C204(0.82); C153(0.87); C159(0.90); C479(1.12)  LDD1571  [11]
 LDCM0368  CL10 HEK-293T C204(0.95); C153(0.85); C159(1.00); C479(0.98)  LDD1572  [11]
 LDCM0369  CL100 HEK-293T C204(1.16); C153(0.82); C159(0.94); C414(0.82)  LDD1573  [11]
 LDCM0370  CL101 HEK-293T C204(0.87); C153(0.95); C159(0.94); C479(1.02)  LDD1574  [11]
 LDCM0371  CL102 HEK-293T C204(0.98); C153(1.04); C159(0.90); C387(1.05)  LDD1575  [11]
 LDCM0372  CL103 HEK-293T C204(1.07); C153(0.98); C159(0.95); C414(0.90)  LDD1576  [11]
 LDCM0373  CL104 HEK-293T C204(1.07); C153(0.95); C159(0.99); C414(0.79)  LDD1577  [11]
 LDCM0374  CL105 HEK-293T C204(0.99); C153(0.95); C159(0.79); C479(1.10)  LDD1578  [11]
 LDCM0375  CL106 HEK-293T C204(1.03); C153(0.99); C159(0.84); C387(0.96)  LDD1579  [11]
 LDCM0376  CL107 HEK-293T C204(1.01); C153(1.01); C159(1.07); C414(1.04)  LDD1580  [11]
 LDCM0377  CL108 HEK-293T C204(1.13); C153(1.01); C159(0.95); C414(0.77)  LDD1581  [11]
 LDCM0378  CL109 HEK-293T C204(0.89); C153(1.01); C159(0.86); C479(1.11)  LDD1582  [11]
 LDCM0379  CL11 HEK-293T C204(1.55); C153(0.96); C159(1.10); C479(1.02)  LDD1583  [11]
 LDCM0380  CL110 HEK-293T C204(1.06); C153(0.98); C159(0.86); C387(1.14)  LDD1584  [11]
 LDCM0381  CL111 HEK-293T C204(1.06); C153(0.98); C159(0.93); C414(1.02)  LDD1585  [11]
 LDCM0382  CL112 HEK-293T C204(1.20); C153(0.91); C159(0.95); C414(0.82)  LDD1586  [11]
 LDCM0383  CL113 HEK-293T C204(0.83); C153(1.01); C159(0.93); C479(1.19)  LDD1587  [11]
 LDCM0384  CL114 HEK-293T C204(0.93); C153(0.98); C159(0.93); C387(1.19)  LDD1588  [11]
 LDCM0385  CL115 HEK-293T C204(0.99); C153(1.04); C159(1.03); C414(1.00)  LDD1589  [11]
 LDCM0386  CL116 HEK-293T C204(1.15); C153(0.93); C159(0.96); C414(0.81)  LDD1590  [11]
 LDCM0387  CL117 HEK-293T C204(0.84); C153(1.05); C159(0.93); C479(1.18)  LDD1591  [11]
 LDCM0388  CL118 HEK-293T C204(1.00); C153(1.04); C159(1.02); C387(1.16)  LDD1592  [11]
 LDCM0389  CL119 HEK-293T C204(0.93); C153(1.00); C159(0.98); C414(0.93)  LDD1593  [11]
 LDCM0390  CL12 HEK-293T C204(1.48); C153(1.09); C159(1.08); C479(1.09)  LDD1594  [11]
 LDCM0391  CL120 HEK-293T C204(1.04); C153(0.88); C159(0.96); C414(0.91)  LDD1595  [11]
 LDCM0392  CL121 HEK-293T C204(0.90); C153(0.94); C159(0.83); C479(1.09)  LDD1596  [11]
 LDCM0393  CL122 HEK-293T C204(0.99); C153(1.06); C159(0.85); C387(1.01)  LDD1597  [11]
 LDCM0394  CL123 HEK-293T C204(0.88); C153(1.00); C159(0.91); C414(1.11)  LDD1598  [11]
 LDCM0395  CL124 HEK-293T C204(1.04); C153(1.07); C159(0.91); C414(0.83)  LDD1599  [11]
 LDCM0396  CL125 HEK-293T C204(0.91); C153(0.94); C159(0.85); C479(1.14)  LDD1600  [11]
 LDCM0397  CL126 HEK-293T C204(1.11); C153(1.00); C159(0.94); C387(1.29)  LDD1601  [11]
 LDCM0398  CL127 HEK-293T C204(0.97); C153(0.99); C159(1.04); C414(1.27)  LDD1602  [11]
 LDCM0399  CL128 HEK-293T C204(1.10); C153(0.95); C159(0.94); C414(0.93)  LDD1603  [11]
 LDCM0400  CL13 HEK-293T C204(0.99); C153(0.88); C159(0.86); C479(1.17)  LDD1604  [11]
 LDCM0401  CL14 HEK-293T C204(1.11); C153(1.02); C159(1.01); C387(0.96)  LDD1605  [11]
 LDCM0402  CL15 HEK-293T C204(0.90); C153(0.91); C159(0.97); C414(1.20)  LDD1606  [11]
 LDCM0403  CL16 HEK-293T C204(1.14); C153(0.95); C159(0.94); C414(1.11)  LDD1607  [11]
 LDCM0404  CL17 HEK-293T C204(1.02); C153(0.82); C159(0.88); C414(1.02)  LDD1608  [11]
 LDCM0405  CL18 HEK-293T C204(0.96); C159(0.91); C479(1.01); C414(0.68)  LDD1609  [11]
 LDCM0406  CL19 HEK-293T C204(1.07); C153(1.02); C159(0.99); C479(1.03)  LDD1610  [11]
 LDCM0407  CL2 HEK-293T C204(1.07); C153(1.05); C159(1.00); C387(0.90)  LDD1611  [11]
 LDCM0408  CL20 HEK-293T C204(1.49); C153(0.96); C159(1.08); C479(1.04)  LDD1612  [11]
 LDCM0409  CL21 HEK-293T C204(1.08); C153(0.90); C159(1.02); C414(1.37)  LDD1613  [11]
 LDCM0410  CL22 HEK-293T C204(1.19); C153(0.94); C159(1.23); C479(1.08)  LDD1614  [11]
 LDCM0411  CL23 HEK-293T C204(2.16); C153(1.04); C159(1.14); C479(1.13)  LDD1615  [11]
 LDCM0412  CL24 HEK-293T C204(1.80); C153(0.93); C159(1.10); C479(1.11)  LDD1616  [11]
 LDCM0413  CL25 HEK-293T C204(0.85); C153(0.90); C159(0.94); C479(1.10)  LDD1617  [11]
 LDCM0414  CL26 HEK-293T C204(1.04); C153(1.10); C159(1.03); C387(0.94)  LDD1618  [11]
 LDCM0415  CL27 HEK-293T C204(1.03); C153(0.98); C159(1.00); C414(0.90)  LDD1619  [11]
 LDCM0416  CL28 HEK-293T C204(1.13); C153(0.99); C159(0.99); C414(1.08)  LDD1620  [11]
 LDCM0417  CL29 HEK-293T C204(1.02); C153(0.92); C159(0.99); C414(0.76)  LDD1621  [11]
 LDCM0418  CL3 HEK-293T C204(0.97); C153(0.92); C159(1.11); C414(1.08)  LDD1622  [11]
 LDCM0419  CL30 HEK-293T C204(0.91); C159(0.96); C479(0.85); C414(0.72)  LDD1623  [11]
 LDCM0420  CL31 HEK-293T C204(1.11); C153(1.03); C159(1.00); C479(1.07)  LDD1624  [11]
 LDCM0421  CL32 HEK-293T C204(1.28); C153(1.07); C159(1.08); C479(0.97)  LDD1625  [11]
 LDCM0422  CL33 HEK-293T C204(0.99); C153(0.91); C159(1.00); C414(1.43)  LDD1626  [11]
 LDCM0423  CL34 HEK-293T C204(1.26); C153(1.02); C159(1.12); C479(1.10)  LDD1627  [11]
 LDCM0424  CL35 HEK-293T C204(1.83); C153(1.06); C159(1.12); C479(1.15)  LDD1628  [11]
 LDCM0425  CL36 HEK-293T C204(1.69); C153(0.92); C159(1.12); C479(1.24)  LDD1629  [11]
 LDCM0426  CL37 HEK-293T C204(0.84); C153(0.96); C159(0.97); C479(1.01)  LDD1630  [11]
 LDCM0428  CL39 HEK-293T C204(1.05); C153(0.98); C159(1.02); C414(1.12)  LDD1632  [11]
 LDCM0429  CL4 HEK-293T C204(1.02); C153(0.98); C159(0.92); C414(0.94)  LDD1633  [11]
 LDCM0430  CL40 HEK-293T C204(1.11); C153(1.01); C159(0.97); C414(0.92)  LDD1634  [11]
 LDCM0431  CL41 HEK-293T C204(1.02); C153(0.82); C159(0.96); C414(0.97)  LDD1635  [11]
 LDCM0432  CL42 HEK-293T C204(0.95); C159(1.06); C479(1.10); C414(0.73)  LDD1636  [11]
 LDCM0433  CL43 HEK-293T C204(1.02); C153(1.06); C159(1.10); C479(0.97)  LDD1637  [11]
 LDCM0434  CL44 HEK-293T C204(1.24); C153(1.04); C159(1.07); C479(0.98)  LDD1638  [11]
 LDCM0435  CL45 HEK-293T C204(1.14); C153(0.99); C159(1.01); C414(1.17)  LDD1639  [11]
 LDCM0436  CL46 HEK-293T C204(1.22); C153(1.03); C159(1.13); C479(1.15)  LDD1640  [11]
 LDCM0437  CL47 HEK-293T C204(1.81); C153(1.05); C159(1.07); C479(1.06)  LDD1641  [11]
 LDCM0438  CL48 HEK-293T C204(1.93); C153(0.98); C159(1.13); C479(1.11)  LDD1642  [11]
 LDCM0439  CL49 HEK-293T C204(0.84); C153(0.92); C159(0.90); C479(1.19)  LDD1643  [11]
 LDCM0440  CL5 HEK-293T C204(1.07); C153(1.00); C159(0.92); C414(0.93)  LDD1644  [11]
 LDCM0441  CL50 HEK-293T C204(0.99); C153(1.07); C159(1.05); C387(0.92)  LDD1645  [11]
 LDCM0443  CL52 HEK-293T C204(1.11); C153(0.98); C159(1.01); C414(0.81)  LDD1646  [11]
 LDCM0444  CL53 HEK-293T C204(1.03); C153(0.87); C159(0.93); C414(1.25)  LDD1647  [11]
 LDCM0445  CL54 HEK-293T C204(0.85); C159(0.83); C479(0.75); C414(0.78)  LDD1648  [11]
 LDCM0446  CL55 HEK-293T C204(1.05); C153(0.98); C159(1.05); C479(1.04)  LDD1649  [11]
 LDCM0447  CL56 HEK-293T C204(1.22); C153(0.96); C159(1.02); C479(0.94)  LDD1650  [11]
 LDCM0448  CL57 HEK-293T C204(1.01); C153(0.97); C159(0.97); C414(1.16)  LDD1651  [11]
 LDCM0449  CL58 HEK-293T C204(1.14); C153(1.02); C159(1.18); C479(0.99)  LDD1652  [11]
 LDCM0450  CL59 HEK-293T C204(1.91); C153(1.10); C159(1.16); C479(1.23)  LDD1653  [11]
 LDCM0451  CL6 HEK-293T C204(0.85); C159(0.90); C479(0.77); C414(0.84)  LDD1654  [11]
 LDCM0452  CL60 HEK-293T C204(1.86); C153(0.99); C159(1.13); C479(1.05)  LDD1655  [11]
 LDCM0453  CL61 HEK-293T C204(0.90); C153(1.05); C159(0.95); C479(1.15)  LDD1656  [11]
 LDCM0454  CL62 HEK-293T C204(1.09); C153(1.08); C159(1.07); C387(1.07)  LDD1657  [11]
 LDCM0455  CL63 HEK-293T C204(1.01); C153(1.02); C159(0.97); C414(0.99)  LDD1658  [11]
 LDCM0456  CL64 HEK-293T C204(1.04); C153(0.88); C159(0.91); C414(0.96)  LDD1659  [11]
 LDCM0457  CL65 HEK-293T C204(1.10); C153(0.90); C159(1.01); C414(1.09)  LDD1660  [11]
 LDCM0458  CL66 HEK-293T C204(0.93); C159(0.94); C479(1.10); C414(0.74)  LDD1661  [11]
 LDCM0459  CL67 HEK-293T C204(1.11); C153(1.08); C159(1.08); C479(0.92)  LDD1662  [11]
 LDCM0460  CL68 HEK-293T C204(1.18); C153(0.97); C159(1.13); C479(0.98)  LDD1663  [11]
 LDCM0461  CL69 HEK-293T C204(1.05); C153(1.04); C159(1.04); C414(1.08)  LDD1664  [11]
 LDCM0462  CL7 HEK-293T C204(1.06); C153(0.92); C159(1.01); C479(1.03)  LDD1665  [11]
 LDCM0463  CL70 HEK-293T C204(1.23); C153(1.07); C159(1.10); C479(1.00)  LDD1666  [11]
 LDCM0464  CL71 HEK-293T C204(1.71); C153(1.17); C159(1.16); C479(1.19)  LDD1667  [11]
 LDCM0465  CL72 HEK-293T C204(1.57); C153(1.05); C159(1.10); C479(1.11)  LDD1668  [11]
 LDCM0466  CL73 HEK-293T C204(0.90); C153(0.89); C159(0.84); C479(1.06)  LDD1669  [11]
 LDCM0467  CL74 HEK-293T C204(1.11); C153(1.08); C159(1.00); C387(1.11)  LDD1670  [11]
 LDCM0469  CL76 HEK-293T C204(1.08); C153(0.91); C159(1.01); C414(0.96)  LDD1672  [11]
 LDCM0470  CL77 HEK-293T C204(1.03); C153(0.88); C159(0.93); C414(1.10)  LDD1673  [11]
 LDCM0471  CL78 HEK-293T C204(0.96); C159(1.01); C479(0.98); C414(0.93)  LDD1674  [11]
 LDCM0472  CL79 HEK-293T C204(1.12); C153(1.18); C159(1.10); C479(1.05)  LDD1675  [11]
 LDCM0473  CL8 HEK-293T C204(1.12); C153(0.79); C159(0.86); C479(1.58)  LDD1676  [11]
 LDCM0474  CL80 HEK-293T C204(1.24); C153(0.93); C159(1.15); C479(1.12)  LDD1677  [11]
 LDCM0475  CL81 HEK-293T C204(1.11); C153(1.04); C159(1.22); C414(1.06)  LDD1678  [11]
 LDCM0476  CL82 HEK-293T C204(1.11); C153(1.01); C159(1.09); C479(1.12)  LDD1679  [11]
 LDCM0477  CL83 HEK-293T C204(1.60); C153(1.08); C159(1.03); C479(1.15)  LDD1680  [11]
 LDCM0478  CL84 HEK-293T C204(1.73); C153(1.02); C159(1.01); C479(1.04)  LDD1681  [11]
 LDCM0479  CL85 HEK-293T C204(0.94); C153(0.95); C159(0.96); C479(1.16)  LDD1682  [11]
 LDCM0480  CL86 HEK-293T C204(1.10); C153(1.08); C159(0.93); C387(1.17)  LDD1683  [11]
 LDCM0481  CL87 HEK-293T C204(1.05); C153(0.97); C159(0.94); C414(1.28)  LDD1684  [11]
 LDCM0482  CL88 HEK-293T C204(1.15); C153(0.94); C159(0.99); C414(0.68)  LDD1685  [11]
 LDCM0483  CL89 HEK-293T C204(1.11); C153(0.86); C159(1.04); C414(0.96)  LDD1686  [11]
 LDCM0484  CL9 HEK-293T C204(1.03); C153(0.93); C159(1.02); C414(1.14)  LDD1687  [11]
 LDCM0485  CL90 HEK-293T C204(0.86); C159(0.75); C479(1.14); C414(1.08)  LDD1688  [11]
 LDCM0486  CL91 HEK-293T C204(1.15); C153(1.09); C159(1.03); C479(1.06)  LDD1689  [11]
 LDCM0487  CL92 HEK-293T C204(1.10); C153(0.94); C159(1.00); C479(0.93)  LDD1690  [11]
 LDCM0488  CL93 HEK-293T C204(1.02); C153(1.01); C159(1.02); C414(1.24)  LDD1691  [11]
 LDCM0489  CL94 HEK-293T C204(1.20); C153(0.99); C159(1.16); C479(0.96)  LDD1692  [11]
 LDCM0490  CL95 HEK-293T C204(1.71); C153(0.84); C159(0.90); C479(1.01)  LDD1693  [11]
 LDCM0491  CL96 HEK-293T C204(1.61); C153(0.97); C159(1.09); C479(0.96)  LDD1694  [11]
 LDCM0492  CL97 HEK-293T C204(0.89); C153(0.86); C159(0.89); C479(1.06)  LDD1695  [11]
 LDCM0493  CL98 HEK-293T C204(1.03); C153(1.01); C159(1.08); C387(0.94)  LDD1696  [11]
 LDCM0494  CL99 HEK-293T C204(0.98); C153(1.00); C159(0.96); C414(0.87)  LDD1697  [11]
 LDCM0495  E2913 HEK-293T C204(0.99); C153(1.00); C159(1.03); C414(0.91)  LDD1698  [11]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C204(2.79)  LDD1702  [2]
 LDCM0625  F8 Ramos C204(1.45)  LDD2187  [12]
 LDCM0572  Fragment10 Ramos C204(1.45)  LDD2189  [12]
 LDCM0573  Fragment11 Ramos C204(5.70)  LDD2190  [12]
 LDCM0574  Fragment12 Ramos C204(0.82)  LDD2191  [12]
 LDCM0575  Fragment13 Ramos C204(0.89); C414(0.69)  LDD2192  [12]
 LDCM0576  Fragment14 Ramos C204(0.82); C414(2.06)  LDD2193  [12]
 LDCM0579  Fragment20 Ramos C204(1.01); C414(0.85)  LDD2194  [12]
 LDCM0580  Fragment21 Ramos C204(1.01); C414(1.45)  LDD2195  [12]
 LDCM0582  Fragment23 Ramos C204(0.79)  LDD2196  [12]
 LDCM0578  Fragment27 Ramos C204(0.80); C414(0.56)  LDD2197  [12]
 LDCM0586  Fragment28 Ramos C204(0.73)  LDD2198  [12]
 LDCM0588  Fragment30 Ramos C204(1.21); C414(0.81)  LDD2199  [12]
 LDCM0589  Fragment31 Ramos C204(0.78); C414(0.76)  LDD2200  [12]
 LDCM0590  Fragment32 Ramos C204(1.77)  LDD2201  [12]
 LDCM0468  Fragment33 HEK-293T C204(0.99); C153(1.04); C159(0.94); C414(0.92)  LDD1671  [11]
 LDCM0596  Fragment38 Ramos C204(0.90); C414(2.97)  LDD2203  [12]
 LDCM0566  Fragment4 Ramos C204(0.84); C414(2.53)  LDD2184  [12]
 LDCM0427  Fragment51 HEK-293T C204(1.06); C153(1.06); C159(1.07); C387(0.92)  LDD1631  [11]
 LDCM0610  Fragment52 Ramos C204(0.90)  LDD2204  [12]
 LDCM0614  Fragment56 Ramos C204(1.76)  LDD2205  [12]
 LDCM0569  Fragment7 Ramos C204(1.08)  LDD2186  [12]
 LDCM0571  Fragment9 Ramos C204(1.03)  LDD2188  [12]
 LDCM0022  KB02 HEK-293T C204(0.98); C153(0.92); C159(1.11); C479(1.02)  LDD1492  [11]
 LDCM0023  KB03 Jurkat C159(13.14)  LDD0209  [4]
 LDCM0024  KB05 COLO792 C223(1.78)  LDD3310  [13]
 LDCM0503  Nucleophilic fragment 14b MDA-MB-231 C204(0.91)  LDD2096  [2]
 LDCM0505  Nucleophilic fragment 15b MDA-MB-231 C204(1.02)  LDD2098  [2]
 LDCM0515  Nucleophilic fragment 20b MDA-MB-231 C204(0.89)  LDD2108  [2]
 LDCM0523  Nucleophilic fragment 24b MDA-MB-231 C204(0.73)  LDD2116  [2]
 LDCM0525  Nucleophilic fragment 25b MDA-MB-231 C204(1.09)  LDD2118  [2]
 LDCM0531  Nucleophilic fragment 28b MDA-MB-231 C204(0.84)  LDD2124  [2]
 LDCM0532  Nucleophilic fragment 29a MDA-MB-231 C204(0.84)  LDD2125  [2]
 LDCM0533  Nucleophilic fragment 29b MDA-MB-231 C204(1.34)  LDD2126  [2]
 LDCM0547  Nucleophilic fragment 41 MDA-MB-231 C204(0.87)  LDD2141  [2]
 LDCM0552  Nucleophilic fragment 6a MDA-MB-231 C204(1.01)  LDD2146  [2]
 LDCM0555  Nucleophilic fragment 7b MDA-MB-231 C204(1.39)  LDD2149  [2]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Other
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Nuclear receptor 2C2-associated protein (NR2C2AP) NR2C2AP family Q86WQ0
Juxtaposed with another zinc finger protein 1 (JAZF1) . Q86VZ6

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
3 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
4 Covalent Inhibition by a Natural Product-Inspired Latent Electrophile. J Am Chem Soc. 2023 May 24;145(20):11097-11109. doi: 10.1021/jacs.3c00598. Epub 2023 May 15.
5 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
6 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
7 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
8 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
9 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
10 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
11 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
12 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578
13 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840