Details of the Target

General Information of Target

Target ID LDTP04180
Target Name Retinoic acid receptor RXR-gamma (RXRG)
Gene Name RXRG
Gene ID 6258
Synonyms
NR2B3; Retinoic acid receptor RXR-gamma; Nuclear receptor subfamily 2 group B member 3; Retinoid X receptor gamma
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MYGNYSHFMKFPAGYGGSPGHTGSTSMSPSAALSTGKPMDSHPSYTDTPVSAPRTLSAVG
TPLNALGSPYRVITSAMGPPSGALAAPPGINLVAPPSSQLNVVNSVSSSEDIKPLPGLPG
IGNMNYPSTSPGSLVKHICAICGDRSSGKHYGVYSCEGCKGFFKRTIRKDLIYTCRDNKD
CLIDKRQRNRCQYCRYQKCLVMGMKREAVQEERQRSRERAESEAECATSGHEDMPVERIL
EAELAVEPKTESYGDMNMENSTNDPVTNICHAADKQLFTLVEWAKRIPHFSDLTLEDQVI
LLRAGWNELLIASFSHRSVSVQDGILLATGLHVHRSSAHSAGVGSIFDRVLTELVSKMKD
MQMDKSELGCLRAIVLFNPDAKGLSNPSEVETLREKVYATLEAYTKQKYPEQPGRFAKLL
LRLPALRSIGLKCLEHLFFFKLIGDTPIDTFLMEMLETPLQIT
Target Type
Successful
Target Bioclass
Transcription factor
Family
Nuclear hormone receptor family, NR2 subfamily
Subcellular location
Nucleus
Function
Receptor for retinoic acid. Retinoic acid receptors bind as heterodimers to their target response elements in response to their ligands, all-trans or 9-cis retinoic acid, and regulate gene expression in various biological processes. The RAR/RXR heterodimers bind to the retinoic acid response elements (RARE) composed of tandem 5'-AGGTCA-3' sites known as DR1-DR5. The high affinity ligand for RXRs is 9-cis retinoic acid.
TTD ID
T46456
Uniprot ID
P48443
DrugMap ID
TTH029C
Ensemble ID
ENST00000359842.10
HGNC ID
HGNC:10479
ChEMBL ID
CHEMBL2004

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 2 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C139(0.90); C142(0.90)  LDD0078  [1]
IA-alkyne
 Probe Info  		N.A.  LDD0175  [2]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HCT 116 C139(0.71); C142(0.71)  LDD0531  [1]
 LDCM0215  AC10 PaTu 8988t C139(1.55); C142(1.55)  LDD1094  [1]
 LDCM0216  AC100 PaTu 8988t C139(1.37); C142(1.37)  LDD1095  [1]
 LDCM0217  AC101 PaTu 8988t C139(1.35); C142(1.35)  LDD1096  [1]
 LDCM0218  AC102 PaTu 8988t C139(1.32); C142(1.32)  LDD1097  [1]
 LDCM0219  AC103 PaTu 8988t C139(0.96); C142(0.96)  LDD1098  [1]
 LDCM0220  AC104 PaTu 8988t C139(1.53); C142(1.53)  LDD1099  [1]
 LDCM0221  AC105 PaTu 8988t C139(1.14); C142(1.14)  LDD1100  [1]
 LDCM0222  AC106 PaTu 8988t C139(1.12); C142(1.12)  LDD1101  [1]
 LDCM0223  AC107 PaTu 8988t C139(0.94); C142(0.94)  LDD1102  [1]
 LDCM0224  AC108 PaTu 8988t C139(1.10); C142(1.10)  LDD1103  [1]
 LDCM0225  AC109 PaTu 8988t C139(1.71); C142(1.71)  LDD1104  [1]
 LDCM0226  AC11 PaTu 8988t C139(1.29); C142(1.29)  LDD1105  [1]
 LDCM0227  AC110 PaTu 8988t C139(1.29); C142(1.29)  LDD1106  [1]
 LDCM0228  AC111 PaTu 8988t C139(1.51); C142(1.51)  LDD1107  [1]
 LDCM0229  AC112 PaTu 8988t C139(1.00); C142(1.00)  LDD1108  [1]
 LDCM0230  AC113 PaTu 8988t C139(0.92); C142(0.92)  LDD1109  [1]
 LDCM0231  AC114 PaTu 8988t C139(1.07); C142(1.07)  LDD1110  [1]
 LDCM0232  AC115 PaTu 8988t C139(0.91); C142(0.91)  LDD1111  [1]
 LDCM0233  AC116 PaTu 8988t C139(1.02); C142(1.02)  LDD1112  [1]
 LDCM0234  AC117 PaTu 8988t C139(0.92); C142(0.92)  LDD1113  [1]
 LDCM0235  AC118 PaTu 8988t C139(1.00); C142(1.00)  LDD1114  [1]
 LDCM0236  AC119 PaTu 8988t C139(0.93); C142(0.93)  LDD1115  [1]
 LDCM0237  AC12 PaTu 8988t C139(1.26); C142(1.26)  LDD1116  [1]
 LDCM0238  AC120 PaTu 8988t C139(0.91); C142(0.91)  LDD1117  [1]
 LDCM0239  AC121 PaTu 8988t C139(1.05); C142(1.05)  LDD1118  [1]
 LDCM0240  AC122 PaTu 8988t C139(0.94); C142(0.94)  LDD1119  [1]
 LDCM0241  AC123 PaTu 8988t C139(1.01); C142(1.01)  LDD1120  [1]
 LDCM0242  AC124 PaTu 8988t C139(1.11); C142(1.11)  LDD1121  [1]
 LDCM0243  AC125 PaTu 8988t C139(1.01); C142(1.01)  LDD1122  [1]
 LDCM0244  AC126 PaTu 8988t C139(0.93); C142(0.93)  LDD1123  [1]
 LDCM0245  AC127 PaTu 8988t C139(1.04); C142(1.04)  LDD1124  [1]
 LDCM0246  AC128 HCT 116 C139(1.38); C142(1.38)  LDD0563  [1]
 LDCM0247  AC129 HCT 116 C139(0.92); C142(0.92)  LDD0564  [1]
 LDCM0249  AC130 HCT 116 C139(1.15); C142(1.15)  LDD0566  [1]
 LDCM0250  AC131 HCT 116 C139(0.73); C142(0.73)  LDD0567  [1]
 LDCM0251  AC132 HCT 116 C139(0.89); C142(0.89)  LDD0568  [1]
 LDCM0252  AC133 HCT 116 C139(1.03); C142(1.03)  LDD0569  [1]
 LDCM0253  AC134 HCT 116 C139(1.09); C142(1.09)  LDD0570  [1]
 LDCM0254  AC135 HCT 116 C139(1.13); C142(1.13)  LDD0571  [1]
 LDCM0255  AC136 HCT 116 C139(0.98); C142(0.98)  LDD0572  [1]
 LDCM0256  AC137 HCT 116 C139(0.99); C142(0.99)  LDD0573  [1]
 LDCM0257  AC138 HCT 116 C139(1.06); C142(1.06)  LDD0574  [1]
 LDCM0258  AC139 HCT 116 C139(0.99); C142(0.99)  LDD0575  [1]
 LDCM0259  AC14 PaTu 8988t C139(1.11); C142(1.11)  LDD1138  [1]
 LDCM0260  AC140 HCT 116 C139(0.95); C142(0.95)  LDD0577  [1]
 LDCM0261  AC141 HCT 116 C139(1.01); C142(1.01)  LDD0578  [1]
 LDCM0262  AC142 HCT 116 C139(0.88); C142(0.88)  LDD0579  [1]
 LDCM0263  AC143 HCT 116 C139(1.02); C142(1.02)  LDD0580  [1]
 LDCM0264  AC144 HCT 116 C139(1.36); C142(1.36)  LDD0581  [1]
 LDCM0265  AC145 HCT 116 C139(1.46); C142(1.46)  LDD0582  [1]
 LDCM0266  AC146 HCT 116 C139(1.08); C142(1.08)  LDD0583  [1]
 LDCM0267  AC147 HCT 116 C139(1.39); C142(1.39)  LDD0584  [1]
 LDCM0268  AC148 HCT 116 C139(1.61); C142(1.61)  LDD0585  [1]
 LDCM0269  AC149 HCT 116 C139(1.52); C142(1.52)  LDD0586  [1]
 LDCM0270  AC15 PaTu 8988t C139(1.26); C142(1.26)  LDD1149  [1]
 LDCM0271  AC150 HCT 116 C139(1.20); C142(1.20)  LDD0588  [1]
 LDCM0272  AC151 HCT 116 C139(1.07); C142(1.07)  LDD0589  [1]
 LDCM0273  AC152 HCT 116 C139(1.86); C142(1.86)  LDD0590  [1]
 LDCM0274  AC153 HCT 116 C139(1.83); C142(1.83)  LDD0591  [1]
 LDCM0621  AC154 HCT 116 C139(1.31); C142(1.31)  LDD2158  [1]
 LDCM0622  AC155 HCT 116 C139(1.58); C142(1.58)  LDD2159  [1]
 LDCM0623  AC156 HCT 116 C139(1.20); C142(1.20)  LDD2160  [1]
 LDCM0624  AC157 HCT 116 C139(1.03); C142(1.03)  LDD2161  [1]
 LDCM0276  AC17 PaTu 8988t C139(1.41); C142(1.41)  LDD1155  [1]
 LDCM0277  AC18 PaTu 8988t C139(1.48); C142(1.48)  LDD1156  [1]
 LDCM0278  AC19 PaTu 8988t C139(1.24); C142(1.24)  LDD1157  [1]
 LDCM0279  AC2 HCT 116 C139(0.71); C142(0.71)  LDD0596  [1]
 LDCM0280  AC20 PaTu 8988t C139(1.72); C142(1.72)  LDD1159  [1]
 LDCM0281  AC21 PaTu 8988t C139(1.70); C142(1.70)  LDD1160  [1]
 LDCM0282  AC22 PaTu 8988t C139(1.74); C142(1.74)  LDD1161  [1]
 LDCM0283  AC23 PaTu 8988t C139(1.99); C142(1.99)  LDD1162  [1]
 LDCM0284  AC24 PaTu 8988t C139(1.50); C142(1.50)  LDD1163  [1]
 LDCM0285  AC25 PaTu 8988t C139(1.18); C142(1.18)  LDD1164  [1]
 LDCM0286  AC26 PaTu 8988t C139(1.07); C142(1.07)  LDD1165  [1]
 LDCM0287  AC27 PaTu 8988t C139(1.02); C142(1.02)  LDD1166  [1]
 LDCM0288  AC28 PaTu 8988t C139(1.13); C142(1.13)  LDD1167  [1]
 LDCM0289  AC29 PaTu 8988t C139(0.92); C142(0.92)  LDD1168  [1]
 LDCM0290  AC3 HCT 116 C139(0.69); C142(0.69)  LDD0607  [1]
 LDCM0291  AC30 PaTu 8988t C139(1.13); C142(1.13)  LDD1170  [1]
 LDCM0292  AC31 PaTu 8988t C139(0.85); C142(0.85)  LDD1171  [1]
 LDCM0293  AC32 PaTu 8988t C139(1.08); C142(1.08)  LDD1172  [1]
 LDCM0294  AC33 PaTu 8988t C139(1.15); C142(1.15)  LDD1173  [1]
 LDCM0295  AC34 PaTu 8988t C139(1.32); C142(1.32)  LDD1174  [1]
 LDCM0296  AC35 PaTu 8988t C139(1.38); C142(1.38)  LDD1175  [1]
 LDCM0297  AC36 PaTu 8988t C139(1.37); C142(1.37)  LDD1176  [1]
 LDCM0298  AC37 PaTu 8988t C139(0.96); C142(0.96)  LDD1177  [1]
 LDCM0299  AC38 PaTu 8988t C139(1.03); C142(1.03)  LDD1178  [1]
 LDCM0300  AC39 PaTu 8988t C139(1.36); C142(1.36)  LDD1179  [1]
 LDCM0301  AC4 HCT 116 C139(1.00); C142(1.00)  LDD0618  [1]
 LDCM0302  AC40 PaTu 8988t C139(1.24); C142(1.24)  LDD1181  [1]
 LDCM0303  AC41 PaTu 8988t C139(0.83); C142(0.83)  LDD1182  [1]
 LDCM0304  AC42 PaTu 8988t C139(1.04); C142(1.04)  LDD1183  [1]
 LDCM0305  AC43 PaTu 8988t C139(1.09); C142(1.09)  LDD1184  [1]
 LDCM0306  AC44 PaTu 8988t C139(1.12); C142(1.12)  LDD1185  [1]
 LDCM0307  AC45 PaTu 8988t C139(0.96); C142(0.96)  LDD1186  [1]
 LDCM0308  AC46 PaTu 8988t C139(1.05); C142(1.05)  LDD1187  [1]
 LDCM0309  AC47 PaTu 8988t C139(1.12); C142(1.12)  LDD1188  [1]
 LDCM0310  AC48 PaTu 8988t C139(1.14); C142(1.14)  LDD1189  [1]
 LDCM0311  AC49 PaTu 8988t C139(1.30); C142(1.30)  LDD1190  [1]
 LDCM0312  AC5 HCT 116 C139(0.76); C142(0.76)  LDD0629  [1]
 LDCM0313  AC50 PaTu 8988t C139(1.30); C142(1.30)  LDD1192  [1]
 LDCM0314  AC51 PaTu 8988t C139(1.03); C142(1.03)  LDD1193  [1]
 LDCM0315  AC52 PaTu 8988t C139(1.36); C142(1.36)  LDD1194  [1]
 LDCM0316  AC53 PaTu 8988t C139(1.30); C142(1.30)  LDD1195  [1]
 LDCM0317  AC54 PaTu 8988t C139(1.64); C142(1.64)  LDD1196  [1]
 LDCM0318  AC55 PaTu 8988t C139(1.24); C142(1.24)  LDD1197  [1]
 LDCM0319  AC56 PaTu 8988t C139(1.06); C142(1.06)  LDD1198  [1]
 LDCM0320  AC57 HCT 116 C139(1.17); C142(1.17)  LDD0637  [1]
 LDCM0321  AC58 HCT 116 C139(1.04); C142(1.04)  LDD0638  [1]
 LDCM0322  AC59 HCT 116 C139(1.13); C142(1.13)  LDD0639  [1]
 LDCM0323  AC6 PaTu 8988t C139(1.25); C142(1.25)  LDD1202  [1]
 LDCM0324  AC60 HCT 116 C139(1.23); C142(1.23)  LDD0641  [1]
 LDCM0325  AC61 HCT 116 C139(1.15); C142(1.15)  LDD0642  [1]
 LDCM0326  AC62 HCT 116 C139(1.08); C142(1.08)  LDD0643  [1]
 LDCM0327  AC63 HCT 116 C139(1.17); C142(1.17)  LDD0644  [1]
 LDCM0328  AC64 HCT 116 C139(1.26); C142(1.26)  LDD0645  [1]
 LDCM0329  AC65 HCT 116 C139(0.78); C142(0.78)  LDD0646  [1]
 LDCM0330  AC66 HCT 116 C139(0.86); C142(0.86)  LDD0647  [1]
 LDCM0331  AC67 HCT 116 C139(0.79); C142(0.79)  LDD0648  [1]
 LDCM0332  AC68 PaTu 8988t C139(1.07); C142(1.07)  LDD1211  [1]
 LDCM0333  AC69 PaTu 8988t C139(1.14); C142(1.14)  LDD1212  [1]
 LDCM0334  AC7 PaTu 8988t C139(1.11); C142(1.11)  LDD1213  [1]
 LDCM0335  AC70 PaTu 8988t C139(1.13); C142(1.13)  LDD1214  [1]
 LDCM0336  AC71 PaTu 8988t C139(1.07); C142(1.07)  LDD1215  [1]
 LDCM0337  AC72 PaTu 8988t C139(0.91); C142(0.91)  LDD1216  [1]
 LDCM0338  AC73 PaTu 8988t C139(0.99); C142(0.99)  LDD1217  [1]
 LDCM0339  AC74 PaTu 8988t C139(1.15); C142(1.15)  LDD1218  [1]
 LDCM0340  AC75 PaTu 8988t C139(0.98); C142(0.98)  LDD1219  [1]
 LDCM0341  AC76 PaTu 8988t C139(1.07); C142(1.07)  LDD1220  [1]
 LDCM0342  AC77 PaTu 8988t C139(0.90); C142(0.90)  LDD1221  [1]
 LDCM0343  AC78 PaTu 8988t C139(1.15); C142(1.15)  LDD1222  [1]
 LDCM0344  AC79 PaTu 8988t C139(1.20); C142(1.20)  LDD1223  [1]
 LDCM0345  AC8 PaTu 8988t C139(1.08); C142(1.08)  LDD1224  [1]
 LDCM0346  AC80 PaTu 8988t C139(1.05); C142(1.05)  LDD1225  [1]
 LDCM0347  AC81 PaTu 8988t C139(1.13); C142(1.13)  LDD1226  [1]
 LDCM0348  AC82 PaTu 8988t C139(1.25); C142(1.25)  LDD1227  [1]
 LDCM0349  AC83 HCT 116 C139(1.22); C142(1.22)  LDD0666  [1]
 LDCM0350  AC84 HCT 116 C139(1.27); C142(1.27)  LDD0667  [1]
 LDCM0351  AC85 HCT 116 C139(0.97); C142(0.97)  LDD0668  [1]
 LDCM0352  AC86 HCT 116 C139(1.06); C142(1.06)  LDD0669  [1]
 LDCM0353  AC87 HCT 116 C139(0.95); C142(0.95)  LDD0670  [1]
 LDCM0354  AC88 HCT 116 C139(1.19); C142(1.19)  LDD0671  [1]
 LDCM0355  AC89 HCT 116 C139(1.25); C142(1.25)  LDD0672  [1]
 LDCM0357  AC90 HCT 116 C139(0.87); C142(0.87)  LDD0674  [1]
 LDCM0358  AC91 HCT 116 C139(1.52); C142(1.52)  LDD0675  [1]
 LDCM0359  AC92 HCT 116 C139(1.48); C142(1.48)  LDD0676  [1]
 LDCM0360  AC93 HCT 116 C139(1.04); C142(1.04)  LDD0677  [1]
 LDCM0361  AC94 HCT 116 C139(1.17); C142(1.17)  LDD0678  [1]
 LDCM0362  AC95 HCT 116 C139(1.09); C142(1.09)  LDD0679  [1]
 LDCM0363  AC96 HCT 116 C139(1.21); C142(1.21)  LDD0680  [1]
 LDCM0364  AC97 HCT 116 C139(1.28); C142(1.28)  LDD0681  [1]
 LDCM0365  AC98 PaTu 8988t C139(1.28); C142(1.28)  LDD1244  [1]
 LDCM0366  AC99 PaTu 8988t C139(1.17); C142(1.17)  LDD1245  [1]
 LDCM0248  AKOS034007472 PaTu 8988t C139(1.57); C142(1.57)  LDD1127  [1]
 LDCM0356  AKOS034007680 PaTu 8988t C139(1.46); C142(1.46)  LDD1235  [1]
 LDCM0275  AKOS034007705 PaTu 8988t C139(1.29); C142(1.29)  LDD1154  [1]
 LDCM0020  ARS-1620 HCC44 C139(0.90); C142(0.90)  LDD0078  [1]
 LDCM0367  CL1 HCT 116 C139(0.95); C142(0.95)  LDD0684  [1]
 LDCM0368  CL10 HCT 116 C139(1.30); C142(1.30)  LDD0685  [1]
 LDCM0369  CL100 HCT 116 C139(0.67); C142(0.67)  LDD0686  [1]
 LDCM0370  CL101 PaTu 8988t C139(1.25); C142(1.25)  LDD1249  [1]
 LDCM0371  CL102 PaTu 8988t C139(1.30); C142(1.30)  LDD1250  [1]
 LDCM0372  CL103 PaTu 8988t C139(1.66); C142(1.66)  LDD1251  [1]
 LDCM0373  CL104 PaTu 8988t C139(1.17); C142(1.17)  LDD1252  [1]
 LDCM0374  CL105 PaTu 8988t C139(1.19); C142(1.19)  LDD1253  [1]
 LDCM0375  CL106 PaTu 8988t C139(1.34); C142(1.34)  LDD1254  [1]
 LDCM0376  CL107 PaTu 8988t C139(1.10); C142(1.10)  LDD1255  [1]
 LDCM0377  CL108 PaTu 8988t C139(1.33); C142(1.33)  LDD1256  [1]
 LDCM0378  CL109 PaTu 8988t C139(1.39); C142(1.39)  LDD1257  [1]
 LDCM0379  CL11 HCT 116 C139(2.00); C142(2.00)  LDD0696  [1]
 LDCM0380  CL110 PaTu 8988t C139(1.29); C142(1.29)  LDD1259  [1]
 LDCM0381  CL111 PaTu 8988t C139(1.46); C142(1.46)  LDD1260  [1]
 LDCM0382  CL112 PaTu 8988t C139(1.02); C142(1.02)  LDD1261  [1]
 LDCM0383  CL113 PaTu 8988t C139(0.96); C142(0.96)  LDD1262  [1]
 LDCM0384  CL114 PaTu 8988t C139(0.97); C142(0.97)  LDD1263  [1]
 LDCM0385  CL115 PaTu 8988t C139(0.95); C142(0.95)  LDD1264  [1]
 LDCM0386  CL116 PaTu 8988t C139(1.02); C142(1.02)  LDD1265  [1]
 LDCM0387  CL117 PaTu 8988t C139(0.99); C142(0.99)  LDD1266  [1]
 LDCM0388  CL118 PaTu 8988t C139(0.99); C142(0.99)  LDD1267  [1]
 LDCM0389  CL119 PaTu 8988t C139(1.10); C142(1.10)  LDD1268  [1]
 LDCM0390  CL12 HCT 116 C139(1.89); C142(1.89)  LDD0707  [1]
 LDCM0391  CL120 PaTu 8988t C139(1.19); C142(1.19)  LDD1270  [1]
 LDCM0392  CL121 PaTu 8988t C139(1.23); C142(1.23)  LDD1271  [1]
 LDCM0393  CL122 PaTu 8988t C139(0.96); C142(0.96)  LDD1272  [1]
 LDCM0394  CL123 PaTu 8988t C139(1.58); C142(1.58)  LDD1273  [1]
 LDCM0395  CL124 PaTu 8988t C139(1.24); C142(1.24)  LDD1274  [1]
 LDCM0396  CL125 HCT 116 C139(0.95); C142(0.95)  LDD0713  [1]
 LDCM0397  CL126 HCT 116 C139(0.99); C142(0.99)  LDD0714  [1]
 LDCM0398  CL127 HCT 116 C139(0.92); C142(0.92)  LDD0715  [1]
 LDCM0399  CL128 HCT 116 C139(1.44); C142(1.44)  LDD0716  [1]
 LDCM0400  CL13 HCT 116 C139(1.47); C142(1.47)  LDD0717  [1]
 LDCM0401  CL14 HCT 116 C139(1.27); C142(1.27)  LDD0718  [1]
 LDCM0402  CL15 HCT 116 C139(1.86); C142(1.86)  LDD0719  [1]
 LDCM0403  CL16 HCT 116 C139(1.72); C142(1.72)  LDD0720  [1]
 LDCM0404  CL17 HCT 116 C139(1.06); C142(1.06)  LDD0721  [1]
 LDCM0405  CL18 HCT 116 C139(1.87); C142(1.87)  LDD0722  [1]
 LDCM0406  CL19 HCT 116 C139(1.64); C142(1.64)  LDD0723  [1]
 LDCM0407  CL2 HCT 116 C139(1.03); C142(1.03)  LDD0724  [1]
 LDCM0408  CL20 HCT 116 C139(1.80); C142(1.80)  LDD0725  [1]
 LDCM0409  CL21 HCT 116 C139(1.77); C142(1.77)  LDD0726  [1]
 LDCM0410  CL22 HCT 116 C139(2.26); C142(2.26)  LDD0727  [1]
 LDCM0411  CL23 HCT 116 C139(1.80); C142(1.80)  LDD0728  [1]
 LDCM0412  CL24 HCT 116 C139(3.05); C142(3.05)  LDD0729  [1]
 LDCM0413  CL25 HCT 116 C139(1.89); C142(1.89)  LDD0730  [1]
 LDCM0414  CL26 HCT 116 C139(1.39); C142(1.39)  LDD0731  [1]
 LDCM0415  CL27 HCT 116 C139(1.59); C142(1.59)  LDD0732  [1]
 LDCM0416  CL28 HCT 116 C139(1.88); C142(1.88)  LDD0733  [1]
 LDCM0417  CL29 HCT 116 C139(1.71); C142(1.71)  LDD0734  [1]
 LDCM0418  CL3 HCT 116 C139(1.02); C142(1.02)  LDD0735  [1]
 LDCM0419  CL30 HCT 116 C139(1.50); C142(1.50)  LDD0736  [1]
 LDCM0420  CL31 PaTu 8988t C139(1.01); C142(1.01)  LDD1299  [1]
 LDCM0421  CL32 PaTu 8988t C139(1.28); C142(1.28)  LDD1300  [1]
 LDCM0422  CL33 PaTu 8988t C139(1.31); C142(1.31)  LDD1301  [1]
 LDCM0423  CL34 PaTu 8988t C139(1.87); C142(1.87)  LDD1302  [1]
 LDCM0424  CL35 PaTu 8988t C139(1.83); C142(1.83)  LDD1303  [1]
 LDCM0425  CL36 PaTu 8988t C139(2.21); C142(2.21)  LDD1304  [1]
 LDCM0426  CL37 PaTu 8988t C139(1.90); C142(1.90)  LDD1305  [1]
 LDCM0428  CL39 PaTu 8988t C139(1.29); C142(1.29)  LDD1307  [1]
 LDCM0429  CL4 HCT 116 C139(1.46); C142(1.46)  LDD0746  [1]
 LDCM0430  CL40 PaTu 8988t C139(1.29); C142(1.29)  LDD1309  [1]
 LDCM0431  CL41 PaTu 8988t C139(1.86); C142(1.86)  LDD1310  [1]
 LDCM0432  CL42 PaTu 8988t C139(1.94); C142(1.94)  LDD1311  [1]
 LDCM0433  CL43 PaTu 8988t C139(2.35); C142(2.35)  LDD1312  [1]
 LDCM0434  CL44 PaTu 8988t C139(1.70); C142(1.70)  LDD1313  [1]
 LDCM0435  CL45 PaTu 8988t C139(1.44); C142(1.44)  LDD1314  [1]
 LDCM0436  CL46 PaTu 8988t C139(0.90); C142(0.90)  LDD1315  [1]
 LDCM0437  CL47 PaTu 8988t C139(1.07); C142(1.07)  LDD1316  [1]
 LDCM0438  CL48 PaTu 8988t C139(0.92); C142(0.92)  LDD1317  [1]
 LDCM0439  CL49 PaTu 8988t C139(1.13); C142(1.13)  LDD1318  [1]
 LDCM0440  CL5 HCT 116 C139(1.14); C142(1.14)  LDD0757  [1]
 LDCM0441  CL50 PaTu 8988t C139(1.00); C142(1.00)  LDD1320  [1]
 LDCM0442  CL51 PaTu 8988t C139(1.12); C142(1.12)  LDD1321  [1]
 LDCM0443  CL52 PaTu 8988t C139(1.26); C142(1.26)  LDD1322  [1]
 LDCM0444  CL53 PaTu 8988t C139(1.29); C142(1.29)  LDD1323  [1]
 LDCM0445  CL54 PaTu 8988t C139(1.10); C142(1.10)  LDD1324  [1]
 LDCM0446  CL55 PaTu 8988t C139(0.90); C142(0.90)  LDD1325  [1]
 LDCM0447  CL56 PaTu 8988t C139(0.86); C142(0.86)  LDD1326  [1]
 LDCM0448  CL57 PaTu 8988t C139(1.84); C142(1.84)  LDD1327  [1]
 LDCM0449  CL58 PaTu 8988t C139(1.36); C142(1.36)  LDD1328  [1]
 LDCM0450  CL59 PaTu 8988t C139(2.17); C142(2.17)  LDD1329  [1]
 LDCM0451  CL6 HCT 116 C139(1.33); C142(1.33)  LDD0768  [1]
 LDCM0452  CL60 PaTu 8988t C139(1.67); C142(1.67)  LDD1331  [1]
 LDCM0453  CL61 PaTu 8988t C139(1.01); C142(1.01)  LDD1332  [1]
 LDCM0454  CL62 PaTu 8988t C139(1.03); C142(1.03)  LDD1333  [1]
 LDCM0455  CL63 PaTu 8988t C139(0.97); C142(0.97)  LDD1334  [1]
 LDCM0456  CL64 PaTu 8988t C139(1.09); C142(1.09)  LDD1335  [1]
 LDCM0457  CL65 PaTu 8988t C139(0.94); C142(0.94)  LDD1336  [1]
 LDCM0458  CL66 PaTu 8988t C139(1.01); C142(1.01)  LDD1337  [1]
 LDCM0459  CL67 PaTu 8988t C139(1.17); C142(1.17)  LDD1338  [1]
 LDCM0460  CL68 PaTu 8988t C139(1.19); C142(1.19)  LDD1339  [1]
 LDCM0461  CL69 PaTu 8988t C139(1.29); C142(1.29)  LDD1340  [1]
 LDCM0462  CL7 HCT 116 C139(1.56); C142(1.56)  LDD0779  [1]
 LDCM0463  CL70 PaTu 8988t C139(1.13); C142(1.13)  LDD1342  [1]
 LDCM0464  CL71 PaTu 8988t C139(0.83); C142(0.83)  LDD1343  [1]
 LDCM0465  CL72 PaTu 8988t C139(0.88); C142(0.88)  LDD1344  [1]
 LDCM0466  CL73 PaTu 8988t C139(1.27); C142(1.27)  LDD1345  [1]
 LDCM0467  CL74 PaTu 8988t C139(0.91); C142(0.91)  LDD1346  [1]
 LDCM0473  CL8 HCT 116 C139(1.76); C142(1.76)  LDD0790  [1]
 LDCM0484  CL9 HCT 116 C139(1.56); C142(1.56)  LDD0801  [1]
 LDCM0486  CL91 HCT 116 C139(0.91); C142(0.91)  LDD0803  [1]
 LDCM0487  CL92 HCT 116 C139(0.68); C142(0.68)  LDD0804  [1]
 LDCM0488  CL93 HCT 116 C139(0.79); C142(0.79)  LDD0805  [1]
 LDCM0489  CL94 HCT 116 C139(0.86); C142(0.86)  LDD0806  [1]
 LDCM0490  CL95 HCT 116 C139(0.91); C142(0.91)  LDD0807  [1]
 LDCM0491  CL96 HCT 116 C139(0.85); C142(0.85)  LDD0808  [1]
 LDCM0492  CL97 HCT 116 C139(0.69); C142(0.69)  LDD0809  [1]
 LDCM0493  CL98 HCT 116 C139(0.75); C142(0.75)  LDD0810  [1]
 LDCM0494  CL99 HCT 116 C139(0.79); C142(0.79)  LDD0811  [1]
 LDCM0468  Fragment33 PaTu 8988t C139(1.04); C142(1.04)  LDD1347  [1]
 LDCM0427  Fragment51 PaTu 8988t C139(1.99); C142(1.99)  LDD1306  [1]
 LDCM0022  KB02 A101D C370(2.32)  LDD2250  [3]
 LDCM0023  KB03 A101D C175(1.54); C370(4.87)  LDD2667  [3]
 LDCM0024  KB05 SH-4 C175(1.13)  LDD3419  [3]
 LDCM0021  THZ1 HCT 116 C139(1.39); C142(1.39)  LDD2173  [1]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Creatine kinase U-type, mitochondrial (CKMT1A; CKMT1B) ATP:guanido phosphotransferase family P12532
Metallophosphoesterase MPPED2 (MPPED2) UPF0046 family Q15777
Transporter and channel
Click To Hide/Show 3 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Huntingtin (HTT) Huntingtin family P42858
Oxysterols receptor LXR-alpha (NR1H3) Nuclear hormone receptor family Q13133
Alpha-crystallin A chain (CRYAA) Small heat shock protein (HSP20) family P02489
Transcription factor
Click To Hide/Show 3 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Oxysterols receptor LXR-beta (NR1H2) Nuclear hormone receptor family P55055
Retinoic acid receptor alpha (RARA) Nuclear hormone receptor family P10276
Retinoic acid receptor gamma (RARG) Nuclear hormone receptor family P13631
Other
Click To Hide/Show 3 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Cytoplasmic dynein 1 heavy chain 1 (DYNC1H1) Dynein heavy chain family Q14204
PRKCA-binding protein (PICK1) . Q9NRD5
Sprouty-related, EVH1 domain-containing protein 1 (SPRED1) . Q7Z699

The Drug(s) Related To This Target

Approved
Click To Hide/Show 9 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Acitretin Small molecular drug DB00459
Adapalene Small molecular drug DB00210
Alitretinoin Small molecular drug D0G3PI
Bexarotene Small molecular drug DB00307
Bezafibrate Small molecular drug DB01393
Doconexent Small molecular drug DB03756
Rosiglitazone Small molecular drug DB00412
Tretinoin Small molecular drug DB00755
Vitamin A Small molecular drug D0S7WX
Phase 2
Click To Hide/Show 1 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Nrx-4204 Small molecular drug D06QXI
Phase 1
Click To Hide/Show 2 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Irx4204 Small molecular drug D09DJC
9cuab-30 . D07OSS
Investigative
Click To Hide/Show 3 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Agn-34 Small molecular drug D0GR9O
Lg100754 Small molecular drug D0Q9FZ
Phthalic Acid Small molecular drug DB02746
Discontinued
Click To Hide/Show 2 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Etretinate Small molecular drug DB00926
Sr-11237 Small molecular drug D09YUQ

References

1 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
2 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
3 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840