Details of the Target

General Information of Target

Target ID LDTP03933
Target Name Protein Wnt-5a (WNT5A)
Gene Name WNT5A
Gene ID 7474
Synonyms
Protein Wnt-5a
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MKKSIGILSPGVALGMAGSAMSSKFFLVALAIFFSFAQVVIEANSWWSLGMNNPVQMSEV
YIIGAQPLCSQLAGLSQGQKKLCHLYQDHMQYIGEGAKTGIKECQYQFRHRRWNCSTVDN
TSVFGRVMQIGSRETAFTYAVSAAGVVNAMSRACREGELSTCGCSRAARPKDLPRDWLWG
GCGDNIDYGYRFAKEFVDARERERIHAKGSYESARILMNLHNNEAGRRTVYNLADVACKC
HGVSGSCSLKTCWLQLADFRKVGDALKEKYDSAAAMRLNSRGKLVQVNSRFNSPTTQDLV
YIDPSPDYCVRNESTGSLGTQGRLCNKTSEGMDGCELMCCGRGYDQFKTVQTERCHCKFH
WCCYVKCKKCTEIVDQFVCK
Target Type
Literature-reported
Target Bioclass
Other
Family
Wnt family
Subcellular location
Secreted, extracellular space, extracellular matrix
Function
Ligand for members of the frizzled family of seven transmembrane receptors. Can activate or inhibit canonical Wnt signaling, depending on receptor context. In the presence of FZD4, activates beta-catenin signaling. In the presence of ROR2, inhibits the canonical Wnt pathway by promoting beta-catenin degradation through a GSK3-independent pathway which involves down-regulation of beta-catenin-induced reporter gene expression. Suppression of the canonical pathway allows chondrogenesis to occur and inhibits tumor formation. Stimulates cell migration. Decreases proliferation, migration, invasiveness and clonogenicity of carcinoma cells and may act as a tumor suppressor. Mediates motility of melanoma cells. Required during embryogenesis for extension of the primary anterior-posterior axis and for outgrowth of limbs and the genital tubercle. Inhibits type II collagen expression in chondrocytes.
TTD ID
T13175
Uniprot ID
P41221
DrugMap ID
TTKG7F8
Ensemble ID
ENST00000264634.9
HGNC ID
HGNC:12784

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
HCT15 SNV: p.G209D; p.G322D .
MEWO SNV: p.S317L .
NALM6 SNV: p.G316S .
REH SNV: p.D176Y .
SKMEL3 SNV: p.T328A .
SNGM SNV: p.A167V .
SW1573 SNV: p.A97V .
SW620 SNV: p.R191P .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 5 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
OPA-S-S-alkyne
 Probe Info  		K348(1.98); K208(2.67); K269(2.79); K194(2.93)  LDD3494  [1]
DBIA
 Probe Info  		C252(1.25); C240(1.05); C247(1.05); C182(1.01)  LDD0078  [2]
IA-alkyne
 Probe Info  		C83(0.00); C182(0.00)  LDD0162  [3]
IPM
 Probe Info  		N.A.  LDD0147  [4]
Acrolein
 Probe Info  		N.A.  LDD0217  [5]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HEK-293T C164(0.71)  LDD0812  [2]
 LDCM0215  AC10 PaTu 8988t C162(0.50); C164(0.98)  LDD1094  [2]
 LDCM0216  AC100 HEK-293T C164(1.13)  LDD0814  [2]
 LDCM0217  AC101 HEK-293T C164(1.11)  LDD0815  [2]
 LDCM0218  AC102 HEK-293T C164(1.11)  LDD0816  [2]
 LDCM0219  AC103 HEK-293T C164(1.15)  LDD0817  [2]
 LDCM0220  AC104 HEK-293T C164(1.04)  LDD0818  [2]
 LDCM0221  AC105 HEK-293T C164(1.28)  LDD0819  [2]
 LDCM0222  AC106 HEK-293T C164(0.99)  LDD0820  [2]
 LDCM0223  AC107 HEK-293T C164(0.97)  LDD0821  [2]
 LDCM0224  AC108 HEK-293T C164(1.27)  LDD0822  [2]
 LDCM0225  AC109 HEK-293T C164(1.41)  LDD0823  [2]
 LDCM0226  AC11 PaTu 8988t C162(0.48); C164(0.76)  LDD1105  [2]
 LDCM0227  AC110 HEK-293T C164(1.33)  LDD0825  [2]
 LDCM0228  AC111 HEK-293T C164(1.78)  LDD0826  [2]
 LDCM0229  AC112 HEK-293T C164(1.19)  LDD0827  [2]
 LDCM0230  AC113 HEK-293T C164(0.95)  LDD0828  [2]
 LDCM0231  AC114 HEK-293T C164(0.97)  LDD0829  [2]
 LDCM0232  AC115 HEK-293T C164(0.87)  LDD0830  [2]
 LDCM0233  AC116 HEK-293T C164(1.21)  LDD0831  [2]
 LDCM0234  AC117 HEK-293T C164(1.16)  LDD0832  [2]
 LDCM0235  AC118 HEK-293T C164(1.17)  LDD0833  [2]
 LDCM0236  AC119 HEK-293T C164(1.10)  LDD0834  [2]
 LDCM0237  AC12 PaTu 8988t C162(0.43); C164(0.67)  LDD1116  [2]
 LDCM0238  AC120 HEK-293T C164(1.69)  LDD0836  [2]
 LDCM0239  AC121 HEK-293T C164(1.04)  LDD0837  [2]
 LDCM0240  AC122 HEK-293T C164(0.98)  LDD0838  [2]
 LDCM0241  AC123 HEK-293T C164(1.17)  LDD0839  [2]
 LDCM0242  AC124 HEK-293T C164(0.95)  LDD0840  [2]
 LDCM0243  AC125 HEK-293T C164(0.91)  LDD0841  [2]
 LDCM0244  AC126 HEK-293T C164(1.45)  LDD0842  [2]
 LDCM0245  AC127 HEK-293T C164(1.25)  LDD0843  [2]
 LDCM0246  AC128 PaTu 8988t C162(0.93); C164(1.10)  LDD1125  [2]
 LDCM0247  AC129 PaTu 8988t C162(0.65); C164(0.93)  LDD1126  [2]
 LDCM0249  AC130 PaTu 8988t C162(1.10); C164(1.18)  LDD1128  [2]
 LDCM0250  AC131 PaTu 8988t C162(1.16); C164(1.22)  LDD1129  [2]
 LDCM0251  AC132 PaTu 8988t C162(0.68); C164(0.88)  LDD1130  [2]
 LDCM0252  AC133 PaTu 8988t C162(0.78); C164(1.21)  LDD1131  [2]
 LDCM0253  AC134 PaTu 8988t C162(0.99); C164(1.23)  LDD1132  [2]
 LDCM0254  AC135 PaTu 8988t C162(0.98); C164(1.36)  LDD1133  [2]
 LDCM0255  AC136 PaTu 8988t C162(0.81); C164(1.02)  LDD1134  [2]
 LDCM0256  AC137 PaTu 8988t C162(1.01); C164(1.05)  LDD1135  [2]
 LDCM0257  AC138 PaTu 8988t C162(0.83); C164(0.87)  LDD1136  [2]
 LDCM0258  AC139 PaTu 8988t C162(1.12); C164(1.01)  LDD1137  [2]
 LDCM0259  AC14 PaTu 8988t C162(0.54); C164(0.72)  LDD1138  [2]
 LDCM0260  AC140 PaTu 8988t C162(1.16); C164(1.21)  LDD1139  [2]
 LDCM0261  AC141 PaTu 8988t C162(1.27); C164(1.54)  LDD1140  [2]
 LDCM0262  AC142 PaTu 8988t C162(1.16); C164(1.06)  LDD1141  [2]
 LDCM0263  AC143 HEK-293T C164(1.07)  LDD0861  [2]
 LDCM0264  AC144 HEK-293T C164(1.13)  LDD0862  [2]
 LDCM0265  AC145 HEK-293T C164(1.21)  LDD0863  [2]
 LDCM0266  AC146 HEK-293T C164(1.23)  LDD0864  [2]
 LDCM0267  AC147 HEK-293T C164(0.96)  LDD0865  [2]
 LDCM0268  AC148 HEK-293T C164(0.95)  LDD0866  [2]
 LDCM0269  AC149 HEK-293T C164(1.25)  LDD0867  [2]
 LDCM0270  AC15 PaTu 8988t C162(0.46); C164(0.81)  LDD1149  [2]
 LDCM0271  AC150 HEK-293T C164(1.29)  LDD0869  [2]
 LDCM0272  AC151 HEK-293T C164(1.02)  LDD0870  [2]
 LDCM0273  AC152 HEK-293T C164(1.21)  LDD0871  [2]
 LDCM0274  AC153 HEK-293T C164(0.90)  LDD0872  [2]
 LDCM0621  AC154 HEK-293T C164(1.24)  LDD2162  [2]
 LDCM0622  AC155 HEK-293T C164(1.31)  LDD2163  [2]
 LDCM0623  AC156 HEK-293T C164(1.33)  LDD2164  [2]
 LDCM0624  AC157 HEK-293T C164(1.49)  LDD2165  [2]
 LDCM0276  AC17 HEK-293T C164(1.38)  LDD0874  [2]
 LDCM0277  AC18 HEK-293T C164(1.34)  LDD0875  [2]
 LDCM0278  AC19 HEK-293T C164(1.41)  LDD0876  [2]
 LDCM0279  AC2 HEK-293T C164(1.08)  LDD0877  [2]
 LDCM0280  AC20 HEK-293T C164(1.49)  LDD0878  [2]
 LDCM0281  AC21 HEK-293T C164(1.33)  LDD0879  [2]
 LDCM0282  AC22 HEK-293T C164(1.28)  LDD0880  [2]
 LDCM0283  AC23 HEK-293T C164(1.34)  LDD0881  [2]
 LDCM0284  AC24 HEK-293T C164(1.25)  LDD0882  [2]
 LDCM0285  AC25 HEK-293T C164(0.94); C309(0.83)  LDD1524  [6]
 LDCM0286  AC26 HEK-293T C252(0.88); C164(0.75); C104(0.90)  LDD1525  [6]
 LDCM0287  AC27 HEK-293T C252(1.03); C164(0.91)  LDD1526  [6]
 LDCM0288  AC28 HEK-293T C104(1.05)  LDD1527  [6]
 LDCM0289  AC29 HEK-293T C252(1.15)  LDD1528  [6]
 LDCM0290  AC3 HEK-293T C164(0.70)  LDD0888  [2]
 LDCM0291  AC30 HEK-293T C252(0.84)  LDD1530  [6]
 LDCM0292  AC31 HEK-293T C252(0.99)  LDD1531  [6]
 LDCM0293  AC32 HEK-293T C252(0.99)  LDD1532  [6]
 LDCM0294  AC33 HEK-293T C164(0.96); C309(1.09)  LDD1533  [6]
 LDCM0295  AC34 HEK-293T C252(0.97); C164(0.62); C104(1.19)  LDD1534  [6]
 LDCM0296  AC35 PaTu 8988t C164(1.23)  LDD1175  [2]
 LDCM0297  AC36 PaTu 8988t C164(1.34)  LDD1176  [2]
 LDCM0298  AC37 PaTu 8988t C164(1.30)  LDD1177  [2]
 LDCM0299  AC38 PaTu 8988t C164(1.51)  LDD1178  [2]
 LDCM0300  AC39 PaTu 8988t C164(1.22)  LDD1179  [2]
 LDCM0301  AC4 HEK-293T C164(0.81)  LDD0899  [2]
 LDCM0302  AC40 PaTu 8988t C164(1.35)  LDD1181  [2]
 LDCM0303  AC41 PaTu 8988t C164(0.94)  LDD1182  [2]
 LDCM0304  AC42 PaTu 8988t C164(1.09)  LDD1183  [2]
 LDCM0305  AC43 PaTu 8988t C164(1.08)  LDD1184  [2]
 LDCM0306  AC44 PaTu 8988t C164(1.49)  LDD1185  [2]
 LDCM0307  AC45 PaTu 8988t C164(1.09)  LDD1186  [2]
 LDCM0308  AC46 HEK-293T C252(0.94)  LDD1547  [6]
 LDCM0309  AC47 HEK-293T C252(1.06)  LDD1548  [6]
 LDCM0310  AC48 HEK-293T C252(1.00)  LDD1549  [6]
 LDCM0311  AC49 HEK-293T C164(1.25); C309(0.90)  LDD1550  [6]
 LDCM0312  AC5 HEK-293T C164(0.71)  LDD0910  [2]
 LDCM0313  AC50 HEK-293T C252(0.92); C164(0.95); C104(1.11)  LDD1552  [6]
 LDCM0314  AC51 HEK-293T C252(0.99); C164(1.03)  LDD1553  [6]
 LDCM0315  AC52 HEK-293T C104(1.12)  LDD1554  [6]
 LDCM0316  AC53 HEK-293T C252(1.08)  LDD1555  [6]
 LDCM0317  AC54 HEK-293T C252(1.56)  LDD1556  [6]
 LDCM0318  AC55 HEK-293T C252(0.96)  LDD1557  [6]
 LDCM0319  AC56 HEK-293T C252(1.03)  LDD1558  [6]
 LDCM0320  AC57 HEK-293T C164(1.28)  LDD0918  [2]
 LDCM0321  AC58 HEK-293T C164(1.05)  LDD0919  [2]
 LDCM0322  AC59 HEK-293T C164(1.23)  LDD0920  [2]
 LDCM0323  AC6 PaTu 8988t C162(0.63); C164(0.86)  LDD1202  [2]
 LDCM0324  AC60 HEK-293T C164(1.12)  LDD0922  [2]
 LDCM0325  AC61 HEK-293T C164(1.07)  LDD0923  [2]
 LDCM0326  AC62 HEK-293T C164(0.79)  LDD0924  [2]
 LDCM0327  AC63 HEK-293T C164(1.13)  LDD0925  [2]
 LDCM0328  AC64 HEK-293T C164(1.10)  LDD0926  [2]
 LDCM0329  AC65 HEK-293T C164(1.06)  LDD0927  [2]
 LDCM0330  AC66 HEK-293T C164(0.93)  LDD0928  [2]
 LDCM0331  AC67 HEK-293T C164(1.05)  LDD0929  [2]
 LDCM0332  AC68 HEK-293T C164(0.99)  LDD0930  [2]
 LDCM0333  AC69 HEK-293T C164(0.92)  LDD0931  [2]
 LDCM0334  AC7 PaTu 8988t C162(0.68); C164(0.90)  LDD1213  [2]
 LDCM0335  AC70 HEK-293T C164(1.12)  LDD0933  [2]
 LDCM0336  AC71 HEK-293T C164(1.26)  LDD0934  [2]
 LDCM0337  AC72 HEK-293T C164(1.19)  LDD0935  [2]
 LDCM0338  AC73 HEK-293T C164(1.24)  LDD0936  [2]
 LDCM0339  AC74 HEK-293T C164(1.63)  LDD0937  [2]
 LDCM0340  AC75 HEK-293T C164(1.44)  LDD0938  [2]
 LDCM0341  AC76 HEK-293T C164(1.28)  LDD0939  [2]
 LDCM0342  AC77 HEK-293T C164(1.06)  LDD0940  [2]
 LDCM0343  AC78 HEK-293T C164(1.20)  LDD0941  [2]
 LDCM0344  AC79 HEK-293T C164(1.23)  LDD0942  [2]
 LDCM0345  AC8 PaTu 8988t C162(0.51); C164(0.69)  LDD1224  [2]
 LDCM0346  AC80 HEK-293T C164(1.32)  LDD0944  [2]
 LDCM0347  AC81 HEK-293T C164(1.51)  LDD0945  [2]
 LDCM0348  AC82 HEK-293T C164(1.99)  LDD0946  [2]
 LDCM0365  AC98 HEK-293T C164(1.27)  LDD0963  [2]
 LDCM0366  AC99 HEK-293T C164(1.74)  LDD0964  [2]
 LDCM0248  AKOS034007472 PaTu 8988t C162(0.57); C164(0.82)  LDD1127  [2]
 LDCM0356  AKOS034007680 PaTu 8988t C162(0.65); C164(0.88)  LDD1235  [2]
 LDCM0275  AKOS034007705 PaTu 8988t C162(0.58); C164(0.86)  LDD1154  [2]
 LDCM0020  ARS-1620 HCC44 C252(1.25); C240(1.05); C247(1.05); C182(1.01)  LDD0078  [2]
 LDCM0367  CL1 HEK-293T C252(1.10)  LDD1571  [6]
 LDCM0368  CL10 HEK-293T C252(0.91)  LDD1572  [6]
 LDCM0369  CL100 HEK-293T C164(0.99)  LDD0967  [2]
 LDCM0370  CL101 PaTu 8988t C162(0.57); C164(0.71)  LDD1249  [2]
 LDCM0371  CL102 PaTu 8988t C162(0.54); C164(0.84)  LDD1250  [2]
 LDCM0372  CL103 PaTu 8988t C162(0.48); C164(0.79)  LDD1251  [2]
 LDCM0373  CL104 PaTu 8988t C162(0.52); C164(0.81)  LDD1252  [2]
 LDCM0374  CL105 HEK-293T C164(1.04)  LDD0972  [2]
 LDCM0375  CL106 HEK-293T C164(0.97)  LDD0973  [2]
 LDCM0376  CL107 HEK-293T C164(1.16)  LDD0974  [2]
 LDCM0377  CL108 HEK-293T C164(1.20)  LDD0975  [2]
 LDCM0378  CL109 HEK-293T C164(1.11)  LDD0976  [2]
 LDCM0379  CL11 HEK-293T C252(0.93)  LDD1583  [6]
 LDCM0380  CL110 HEK-293T C164(1.07)  LDD0978  [2]
 LDCM0381  CL111 HEK-293T C164(1.20)  LDD0979  [2]
 LDCM0382  CL112 HEK-293T C164(1.10)  LDD1586  [6]
 LDCM0383  CL113 HEK-293T C252(1.04)  LDD1587  [6]
 LDCM0384  CL114 HEK-293T C164(0.85)  LDD1588  [6]
 LDCM0385  CL115 HEK-293T C252(0.95); C162(1.22)  LDD1589  [6]
 LDCM0386  CL116 HEK-293T C164(1.03)  LDD1590  [6]
 LDCM0387  CL117 PaTu 8988t C164(0.93)  LDD1266  [2]
 LDCM0388  CL118 PaTu 8988t C164(1.05)  LDD1267  [2]
 LDCM0389  CL119 PaTu 8988t C164(0.91)  LDD1268  [2]
 LDCM0390  CL12 HEK-293T C252(1.11)  LDD1594  [6]
 LDCM0391  CL120 PaTu 8988t C164(0.80)  LDD1270  [2]
 LDCM0392  CL121 HEK-293T C252(0.94)  LDD1596  [6]
 LDCM0393  CL122 HEK-293T C164(0.78)  LDD1597  [6]
 LDCM0394  CL123 HEK-293T C252(0.85); C162(1.41)  LDD1598  [6]
 LDCM0395  CL124 HEK-293T C164(1.16)  LDD1599  [6]
 LDCM0396  CL125 HEK-293T C164(1.06)  LDD0994  [2]
 LDCM0397  CL126 HEK-293T C164(1.07)  LDD0995  [2]
 LDCM0398  CL127 HEK-293T C164(0.92)  LDD0996  [2]
 LDCM0399  CL128 HEK-293T C164(0.99)  LDD0997  [2]
 LDCM0400  CL13 HEK-293T C252(1.08)  LDD1604  [6]
 LDCM0401  CL14 HEK-293T C164(1.39)  LDD1605  [6]
 LDCM0402  CL15 HEK-293T C252(0.70); C162(1.35)  LDD1606  [6]
 LDCM0403  CL16 HEK-293T C164(1.53)  LDD1607  [6]
 LDCM0404  CL17 HEK-293T C164(1.05); C309(0.90)  LDD1608  [6]
 LDCM0405  CL18 HEK-293T C252(1.02); C164(0.93); C104(1.20)  LDD1609  [6]
 LDCM0406  CL19 HEK-293T C252(0.91); C164(1.13)  LDD1610  [6]
 LDCM0407  CL2 HEK-293T C164(1.28)  LDD1611  [6]
 LDCM0408  CL20 HEK-293T C104(0.97)  LDD1612  [6]
 LDCM0409  CL21 HEK-293T C252(1.19)  LDD1613  [6]
 LDCM0410  CL22 HEK-293T C252(1.23)  LDD1614  [6]
 LDCM0411  CL23 HEK-293T C252(0.99)  LDD1615  [6]
 LDCM0412  CL24 HEK-293T C252(1.06)  LDD1616  [6]
 LDCM0413  CL25 HEK-293T C252(0.90)  LDD1617  [6]
 LDCM0414  CL26 HEK-293T C164(0.98)  LDD1618  [6]
 LDCM0415  CL27 HEK-293T C252(0.87); C162(1.45)  LDD1619  [6]
 LDCM0416  CL28 HEK-293T C164(0.95)  LDD1620  [6]
 LDCM0417  CL29 HEK-293T C164(0.94); C309(0.98)  LDD1621  [6]
 LDCM0418  CL3 HEK-293T C252(0.86); C162(1.26)  LDD1622  [6]
 LDCM0419  CL30 HEK-293T C252(0.86); C164(0.53); C104(1.12)  LDD1623  [6]
 LDCM0420  CL31 PaTu 8988t C162(1.43); C164(1.37)  LDD1299  [2]
 LDCM0421  CL32 PaTu 8988t C162(1.72); C164(1.63)  LDD1300  [2]
 LDCM0422  CL33 PaTu 8988t C162(1.06); C164(1.21)  LDD1301  [2]
 LDCM0423  CL34 PaTu 8988t C162(1.40); C164(1.32)  LDD1302  [2]
 LDCM0424  CL35 PaTu 8988t C162(1.16); C164(1.33)  LDD1303  [2]
 LDCM0425  CL36 PaTu 8988t C162(0.96); C164(0.97)  LDD1304  [2]
 LDCM0426  CL37 PaTu 8988t C162(1.29); C164(1.28)  LDD1305  [2]
 LDCM0428  CL39 PaTu 8988t C162(1.27); C164(1.25)  LDD1307  [2]
 LDCM0429  CL4 HEK-293T C164(1.03)  LDD1633  [6]
 LDCM0430  CL40 PaTu 8988t C162(1.76); C164(1.71)  LDD1309  [2]
 LDCM0431  CL41 PaTu 8988t C162(1.22); C164(1.15)  LDD1310  [2]
 LDCM0432  CL42 PaTu 8988t C162(1.20); C164(1.58)  LDD1311  [2]
 LDCM0433  CL43 PaTu 8988t C162(1.21); C164(1.48)  LDD1312  [2]
 LDCM0434  CL44 PaTu 8988t C162(1.36); C164(1.33)  LDD1313  [2]
 LDCM0435  CL45 PaTu 8988t C162(1.08); C164(1.08)  LDD1314  [2]
 LDCM0436  CL46 HEK-293T C164(1.06)  LDD1034  [2]
 LDCM0437  CL47 HEK-293T C164(1.08)  LDD1035  [2]
 LDCM0438  CL48 HEK-293T C164(1.46)  LDD1036  [2]
 LDCM0439  CL49 HEK-293T C164(1.38)  LDD1037  [2]
 LDCM0440  CL5 HEK-293T C164(1.21); C309(1.02)  LDD1644  [6]
 LDCM0441  CL50 HEK-293T C164(1.62)  LDD1039  [2]
 LDCM0442  CL51 HEK-293T C164(1.43)  LDD1040  [2]
 LDCM0443  CL52 HEK-293T C164(0.81)  LDD1041  [2]
 LDCM0444  CL53 HEK-293T C164(0.95)  LDD1042  [2]
 LDCM0445  CL54 HEK-293T C164(1.21)  LDD1043  [2]
 LDCM0446  CL55 HEK-293T C164(1.23)  LDD1044  [2]
 LDCM0447  CL56 HEK-293T C164(0.98)  LDD1045  [2]
 LDCM0448  CL57 HEK-293T C164(1.34)  LDD1046  [2]
 LDCM0449  CL58 HEK-293T C164(1.60)  LDD1047  [2]
 LDCM0450  CL59 HEK-293T C164(1.34)  LDD1048  [2]
 LDCM0451  CL6 HEK-293T C252(1.14); C164(0.79); C104(1.41)  LDD1654  [6]
 LDCM0452  CL60 HEK-293T C164(1.14)  LDD1050  [2]
 LDCM0453  CL61 HEK-293T C252(1.07)  LDD1656  [6]
 LDCM0454  CL62 HEK-293T C164(0.91)  LDD1657  [6]
 LDCM0455  CL63 HEK-293T C252(0.91); C162(1.21)  LDD1658  [6]
 LDCM0456  CL64 HEK-293T C164(1.10)  LDD1659  [6]
 LDCM0457  CL65 HEK-293T C164(0.88); C309(1.01)  LDD1660  [6]
 LDCM0458  CL66 HEK-293T C252(1.04); C164(0.91); C104(1.27)  LDD1661  [6]
 LDCM0459  CL67 HEK-293T C252(0.96); C164(1.14)  LDD1662  [6]
 LDCM0460  CL68 HEK-293T C104(1.07)  LDD1663  [6]
 LDCM0461  CL69 HEK-293T C252(0.96)  LDD1664  [6]
 LDCM0462  CL7 HEK-293T C252(0.89); C164(1.21)  LDD1665  [6]
 LDCM0463  CL70 HEK-293T C252(0.91)  LDD1666  [6]
 LDCM0464  CL71 HEK-293T C252(1.04)  LDD1667  [6]
 LDCM0465  CL72 HEK-293T C252(1.00)  LDD1668  [6]
 LDCM0466  CL73 HEK-293T C252(1.07)  LDD1669  [6]
 LDCM0467  CL74 HEK-293T C164(0.81)  LDD1670  [6]
 LDCM0469  CL76 HEK-293T C164(1.17)  LDD1672  [6]
 LDCM0470  CL77 HEK-293T C164(1.20); C309(0.94)  LDD1673  [6]
 LDCM0471  CL78 HEK-293T C252(0.98); C164(0.77); C104(1.10)  LDD1674  [6]
 LDCM0472  CL79 HEK-293T C252(0.96); C164(0.89)  LDD1675  [6]
 LDCM0473  CL8 HEK-293T C104(1.28)  LDD1676  [6]
 LDCM0474  CL80 HEK-293T C104(1.10)  LDD1677  [6]
 LDCM0475  CL81 HEK-293T C252(1.13)  LDD1678  [6]
 LDCM0476  CL82 HEK-293T C252(1.16)  LDD1679  [6]
 LDCM0477  CL83 HEK-293T C252(1.10)  LDD1680  [6]
 LDCM0478  CL84 HEK-293T C252(1.13)  LDD1681  [6]
 LDCM0479  CL85 HEK-293T C252(0.98)  LDD1682  [6]
 LDCM0480  CL86 HEK-293T C164(0.93)  LDD1683  [6]
 LDCM0481  CL87 HEK-293T C252(0.98); C162(1.66)  LDD1684  [6]
 LDCM0482  CL88 HEK-293T C164(1.06)  LDD1685  [6]
 LDCM0483  CL89 HEK-293T C164(1.13); C309(0.92)  LDD1686  [6]
 LDCM0484  CL9 HEK-293T C252(1.14)  LDD1687  [6]
 LDCM0485  CL90 HEK-293T C252(1.16); C164(0.66); C104(1.15)  LDD1688  [6]
 LDCM0486  CL91 HEK-293T C164(0.95)  LDD1084  [2]
 LDCM0487  CL92 HEK-293T C164(0.67)  LDD1085  [2]
 LDCM0488  CL93 HEK-293T C164(0.90)  LDD1086  [2]
 LDCM0489  CL94 HEK-293T C164(1.06)  LDD1087  [2]
 LDCM0490  CL95 HEK-293T C164(1.44)  LDD1088  [2]
 LDCM0491  CL96 HEK-293T C164(0.81)  LDD1089  [2]
 LDCM0492  CL97 HEK-293T C164(0.90)  LDD1090  [2]
 LDCM0493  CL98 HEK-293T C164(1.11)  LDD1091  [2]
 LDCM0494  CL99 HEK-293T C164(0.73)  LDD1092  [2]
 LDCM0495  E2913 HEK-293T C252(1.05); C162(1.25)  LDD1698  [6]
 LDCM0468  Fragment33 HEK-293T C252(0.99); C162(1.41)  LDD1671  [6]
 LDCM0427  Fragment51 PaTu 8988t C162(1.24); C164(1.20)  LDD1306  [2]
 LDCM0022  KB02 HEK-293T C164(0.43)  LDD1492  [6]
 LDCM0023  KB03 HEK-293T C164(0.87)  LDD1497  [6]
 LDCM0024  KB05 TFK-1 C238(3.31)  LDD3472  [7]
 LDCM0109  NEM HeLa N.A.  LDD0227  [5]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Other
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Wnt inhibitory factor 1 (WIF1) . Q9Y5W5

References

1 A chemical proteomics approach for global mapping of functional lysines on cell surface of living cell. Nat Commun. 2024 Apr 8;15(1):2997. doi: 10.1038/s41467-024-47033-w.
Mass spectrometry data entry: PXD042888
2 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
3 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
4 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
5 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
6 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
7 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840