Details of the Target

General Information of Target

Target ID LDTP03922
Target Name ETS translocation variant 3 (ETV3)
Gene Name ETV3
Gene ID 2117
Synonyms
METS; PE1; ETS translocation variant 3; ETS domain transcriptional repressor PE1; PE-1; Mitogenic Ets transcriptional suppressor
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MKAGCSIVEKPEGGGGYQFPDWAYKTESSPGSRQIQLWHFILELLQKEEFRHVIAWQQGE
YGEFVIKDPDEVARLWGRRKCKPQMNYDKLSRALRYYYNKRILHKTKGKRFTYKFNFNKL
VMPNYPFINIRSSGVVPQSAPPVPTASSRFHFPPLDTHSPTNDVQPGRFSASSLTASGQE
SSNGTDRKTELSELEDGSAADWRRGVDPVSSRNAIGGGGIGHQKRKPDIMLPLFARPGMY
PDPHSPFAVSPIPGRGGVLNVPISPALSLTPTIFSYSPSPGLSPFTSSSCFSFNPEEMKH
YLHSQACSVFNYHLSPRTFPRYPGLMVPPLQCQMHPEESTQFSIKLQPPPVGRKNRERVE
SSEESAPVTTPTMASIPPRIKVEPASEKDPESLRQSAREKEEHTQEEGTVPSRTIEEEKG
TIFARPAAPPIWPSVPISTPSGEPLEVTEDSEDRPGKEPSAPEKKEDALMPPKLRLKRRW
NDDPEARELSKSGKFLWNGSGPQGLATAAADA
Target Bioclass
Transcription factor
Family
ETS family
Subcellular location
Nucleus
Function
Transcriptional repressor that contribute to growth arrest during terminal macrophage differentiation by repressing target genes involved in Ras-dependent proliferation. Represses MMP1 promoter activity.
Uniprot ID
P41162
Ensemble ID
ENST00000326786.4
HGNC ID
HGNC:3492

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
22RV1 SNV: p.A366V .
A431 SNV: p.E391Q .
COLO792 Substitution: p.L259F .
HEC1 SNV: p.P126S .
HEC1B SNV: p.P126S .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 6 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
BTD
 Probe Info  		C5(1.11)  LDD2135  [1]
DBIA
 Probe Info  		C81(0.77)  LDD0531  [2]
IA-alkyne
 Probe Info  		N.A.  LDD2241  [3]
IPM
 Probe Info  		N.A.  LDD2156  [4]
AOyne
 Probe Info  		15.00  LDD0443  [5]
NAIA_5
 Probe Info  		N.A.  LDD2223  [6]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HCT 116 C81(0.77)  LDD0531  [2]
 LDCM0215  AC10 HEK-293T C5(1.21); C332(1.04)  LDD1508  [7]
 LDCM0230  AC113 HCT 116 C81(1.11)  LDD0547  [2]
 LDCM0231  AC114 HCT 116 C81(0.99)  LDD0548  [2]
 LDCM0232  AC115 HCT 116 C81(0.94)  LDD0549  [2]
 LDCM0233  AC116 HCT 116 C81(0.98)  LDD0550  [2]
 LDCM0234  AC117 HCT 116 C81(0.98)  LDD0551  [2]
 LDCM0235  AC118 HCT 116 C81(1.19)  LDD0552  [2]
 LDCM0236  AC119 HCT 116 C81(1.27)  LDD0553  [2]
 LDCM0238  AC120 HCT 116 C81(0.95)  LDD0555  [2]
 LDCM0239  AC121 HCT 116 C81(0.87)  LDD0556  [2]
 LDCM0240  AC122 HCT 116 C81(0.98)  LDD0557  [2]
 LDCM0241  AC123 HCT 116 C81(0.92)  LDD0558  [2]
 LDCM0242  AC124 HCT 116 C81(0.87)  LDD0559  [2]
 LDCM0243  AC125 HCT 116 C81(1.01)  LDD0560  [2]
 LDCM0244  AC126 HCT 116 C81(1.11)  LDD0561  [2]
 LDCM0245  AC127 HCT 116 C81(0.99)  LDD0562  [2]
 LDCM0259  AC14 HEK-293T C332(1.02)  LDD1512  [7]
 LDCM0263  AC143 HCT 116 C81(1.13)  LDD0580  [2]
 LDCM0264  AC144 HCT 116 C81(1.00)  LDD0581  [2]
 LDCM0265  AC145 HCT 116 C81(0.92)  LDD0582  [2]
 LDCM0266  AC146 HCT 116 C81(1.16)  LDD0583  [2]
 LDCM0267  AC147 HCT 116 C81(0.94)  LDD0584  [2]
 LDCM0268  AC148 HCT 116 C81(0.93)  LDD0585  [2]
 LDCM0269  AC149 HCT 116 C81(1.12)  LDD0586  [2]
 LDCM0270  AC15 HEK-293T C5(1.01)  LDD1513  [7]
 LDCM0271  AC150 HCT 116 C81(1.02)  LDD0588  [2]
 LDCM0272  AC151 HCT 116 C81(0.91)  LDD0589  [2]
 LDCM0273  AC152 HCT 116 C81(1.15)  LDD0590  [2]
 LDCM0274  AC153 HCT 116 C81(1.16)  LDD0591  [2]
 LDCM0621  AC154 HCT 116 C81(1.00)  LDD2158  [2]
 LDCM0622  AC155 HCT 116 C81(1.23)  LDD2159  [2]
 LDCM0623  AC156 HCT 116 C81(1.18)  LDD2160  [2]
 LDCM0624  AC157 HCT 116 C81(1.08)  LDD2161  [2]
 LDCM0276  AC17 HEK-293T C5(1.07)  LDD1515  [7]
 LDCM0277  AC18 HEK-293T C5(1.03); C332(1.02)  LDD1516  [7]
 LDCM0279  AC2 HCT 116 C81(0.81)  LDD0596  [2]
 LDCM0281  AC21 HEK-293T C5(0.99)  LDD1520  [7]
 LDCM0282  AC22 HEK-293T C332(0.93)  LDD1521  [7]
 LDCM0283  AC23 HEK-293T C5(1.04)  LDD1522  [7]
 LDCM0284  AC24 HEK-293T C5(1.01)  LDD1523  [7]
 LDCM0285  AC25 HEK-293T C5(1.18)  LDD1524  [7]
 LDCM0286  AC26 HEK-293T C5(1.23); C332(1.07)  LDD1525  [7]
 LDCM0289  AC29 HEK-293T C5(0.98)  LDD1528  [7]
 LDCM0290  AC3 HCT 116 C81(0.93)  LDD0607  [2]
 LDCM0291  AC30 HEK-293T C332(1.04)  LDD1530  [7]
 LDCM0292  AC31 HEK-293T C5(1.04)  LDD1531  [7]
 LDCM0293  AC32 HEK-293T C5(1.15)  LDD1532  [7]
 LDCM0294  AC33 HEK-293T C5(1.13)  LDD1533  [7]
 LDCM0295  AC34 HEK-293T C5(1.15); C332(1.10)  LDD1534  [7]
 LDCM0298  AC37 HEK-293T C5(1.01)  LDD1537  [7]
 LDCM0299  AC38 HEK-293T C332(1.00)  LDD1538  [7]
 LDCM0300  AC39 HEK-293T C5(0.99)  LDD1539  [7]
 LDCM0301  AC4 HCT 116 C81(0.85)  LDD0618  [2]
 LDCM0302  AC40 HEK-293T C5(1.22)  LDD1541  [7]
 LDCM0303  AC41 HEK-293T C5(1.11)  LDD1542  [7]
 LDCM0304  AC42 HEK-293T C5(1.11); C332(1.25)  LDD1543  [7]
 LDCM0307  AC45 HEK-293T C5(1.05)  LDD1546  [7]
 LDCM0308  AC46 HCT 116 C81(1.17)  LDD0625  [2]
 LDCM0309  AC47 HCT 116 C81(1.05)  LDD0626  [2]
 LDCM0310  AC48 HCT 116 C81(1.11)  LDD0627  [2]
 LDCM0311  AC49 HCT 116 C81(1.08)  LDD0628  [2]
 LDCM0312  AC5 HCT 116 C81(0.82)  LDD0629  [2]
 LDCM0313  AC50 HCT 116 C81(1.27)  LDD0630  [2]
 LDCM0314  AC51 HCT 116 C81(1.06)  LDD0631  [2]
 LDCM0315  AC52 HCT 116 C81(1.07)  LDD0632  [2]
 LDCM0316  AC53 HCT 116 C81(1.18)  LDD0633  [2]
 LDCM0317  AC54 HCT 116 C81(1.34)  LDD0634  [2]
 LDCM0318  AC55 HCT 116 C81(0.98)  LDD0635  [2]
 LDCM0319  AC56 HCT 116 C81(1.19)  LDD0636  [2]
 LDCM0320  AC57 HEK-293T C5(1.16)  LDD1559  [7]
 LDCM0321  AC58 HEK-293T C5(1.04); C332(1.02)  LDD1560  [7]
 LDCM0323  AC6 HEK-293T C332(1.10)  LDD1562  [7]
 LDCM0325  AC61 HEK-293T C5(0.89)  LDD1564  [7]
 LDCM0326  AC62 HEK-293T C332(1.07)  LDD1565  [7]
 LDCM0327  AC63 HEK-293T C5(1.05)  LDD1566  [7]
 LDCM0328  AC64 HEK-293T C5(1.03)  LDD1567  [7]
 LDCM0334  AC7 HEK-293T C5(1.00)  LDD1568  [7]
 LDCM0345  AC8 HEK-293T C5(1.12)  LDD1569  [7]
 LDCM0248  AKOS034007472 HEK-293T C5(1.01)  LDD1511  [7]
 LDCM0356  AKOS034007680 HEK-293T C5(1.01)  LDD1570  [7]
 LDCM0275  AKOS034007705 HEK-293T C5(1.12)  LDD1514  [7]
 LDCM0367  CL1 HCT 116 C81(1.09)  LDD0684  [2]
 LDCM0368  CL10 HCT 116 C81(0.96)  LDD0685  [2]
 LDCM0369  CL100 HCT 116 C81(0.87)  LDD0686  [2]
 LDCM0372  CL103 HEK-293T C5(1.05); C332(0.91)  LDD1576  [7]
 LDCM0376  CL107 HEK-293T C5(0.99); C332(1.04)  LDD1580  [7]
 LDCM0379  CL11 HCT 116 C81(0.89)  LDD0696  [2]
 LDCM0381  CL111 HEK-293T C5(1.04); C332(1.12)  LDD1585  [7]
 LDCM0385  CL115 HEK-293T C5(0.98); C332(0.96)  LDD1589  [7]
 LDCM0389  CL119 HEK-293T C5(1.18); C332(1.06)  LDD1593  [7]
 LDCM0390  CL12 HCT 116 C81(1.14)  LDD0707  [2]
 LDCM0392  CL121 HCT 116 C81(0.99)  LDD0709  [2]
 LDCM0393  CL122 HCT 116 C81(0.99)  LDD0710  [2]
 LDCM0394  CL123 HCT 116 C81(1.17)  LDD0711  [2]
 LDCM0395  CL124 HCT 116 C81(1.06)  LDD0712  [2]
 LDCM0398  CL127 HEK-293T C5(1.15); C332(1.03)  LDD1602  [7]
 LDCM0400  CL13 HCT 116 C81(1.00)  LDD0717  [2]
 LDCM0401  CL14 HCT 116 C81(0.98)  LDD0718  [2]
 LDCM0402  CL15 HCT 116 C81(0.92)  LDD0719  [2]
 LDCM0404  CL17 HEK-293T C5(1.41)  LDD1608  [7]
 LDCM0405  CL18 HEK-293T C5(1.07); C332(0.95)  LDD1609  [7]
 LDCM0407  CL2 HCT 116 C81(0.99)  LDD0724  [2]
 LDCM0409  CL21 HEK-293T C5(1.07)  LDD1613  [7]
 LDCM0410  CL22 HEK-293T C332(1.01)  LDD1614  [7]
 LDCM0411  CL23 HEK-293T C5(1.00)  LDD1615  [7]
 LDCM0412  CL24 HEK-293T C5(1.06)  LDD1616  [7]
 LDCM0415  CL27 HEK-293T C5(1.04); C332(1.02)  LDD1619  [7]
 LDCM0417  CL29 HEK-293T C5(1.12)  LDD1621  [7]
 LDCM0418  CL3 HCT 116 C81(0.92)  LDD0735  [2]
 LDCM0419  CL30 HEK-293T C5(1.21); C332(1.03)  LDD1623  [7]
 LDCM0422  CL33 HEK-293T C5(1.07)  LDD1626  [7]
 LDCM0423  CL34 HEK-293T C332(0.90)  LDD1627  [7]
 LDCM0424  CL35 HEK-293T C5(0.86)  LDD1628  [7]
 LDCM0425  CL36 HEK-293T C5(0.90)  LDD1629  [7]
 LDCM0428  CL39 HEK-293T C5(1.04); C332(1.06)  LDD1632  [7]
 LDCM0429  CL4 HCT 116 C81(1.35)  LDD0746  [2]
 LDCM0431  CL41 HEK-293T C5(0.96)  LDD1635  [7]
 LDCM0432  CL42 HEK-293T C5(1.07); C332(1.00)  LDD1636  [7]
 LDCM0435  CL45 HEK-293T C5(0.84)  LDD1639  [7]
 LDCM0436  CL46 HCT 116 C81(0.90)  LDD0753  [2]
 LDCM0437  CL47 HCT 116 C81(0.95)  LDD0754  [2]
 LDCM0438  CL48 HCT 116 C81(0.94)  LDD0755  [2]
 LDCM0439  CL49 HCT 116 C81(0.92)  LDD0756  [2]
 LDCM0440  CL5 HCT 116 C81(0.97)  LDD0757  [2]
 LDCM0441  CL50 HCT 116 C81(0.87)  LDD0758  [2]
 LDCM0442  CL51 HCT 116 C81(0.88)  LDD0759  [2]
 LDCM0443  CL52 HCT 116 C81(0.98)  LDD0760  [2]
 LDCM0444  CL53 HCT 116 C81(0.95)  LDD0761  [2]
 LDCM0445  CL54 HCT 116 C81(0.91)  LDD0762  [2]
 LDCM0446  CL55 HCT 116 C81(0.84)  LDD0763  [2]
 LDCM0447  CL56 HCT 116 C81(0.92)  LDD0764  [2]
 LDCM0448  CL57 HCT 116 C81(0.91)  LDD0765  [2]
 LDCM0449  CL58 HCT 116 C81(0.94)  LDD0766  [2]
 LDCM0450  CL59 HCT 116 C81(0.91)  LDD0767  [2]
 LDCM0451  CL6 HCT 116 C81(0.90)  LDD0768  [2]
 LDCM0452  CL60 HCT 116 C81(0.96)  LDD0769  [2]
 LDCM0455  CL63 HEK-293T C5(0.98); C332(1.16)  LDD1658  [7]
 LDCM0457  CL65 HEK-293T C5(1.13)  LDD1660  [7]
 LDCM0458  CL66 HEK-293T C5(1.06); C332(1.02)  LDD1661  [7]
 LDCM0461  CL69 HEK-293T C5(0.89)  LDD1664  [7]
 LDCM0462  CL7 HCT 116 C81(0.96)  LDD0779  [2]
 LDCM0463  CL70 HEK-293T C332(1.05)  LDD1666  [7]
 LDCM0464  CL71 HEK-293T C5(0.98)  LDD1667  [7]
 LDCM0465  CL72 HEK-293T C5(1.09)  LDD1668  [7]
 LDCM0469  CL76 HCT 116 C81(0.96)  LDD0786  [2]
 LDCM0470  CL77 HCT 116 C81(1.20)  LDD0787  [2]
 LDCM0471  CL78 HCT 116 C81(0.97)  LDD0788  [2]
 LDCM0472  CL79 HCT 116 C81(0.95)  LDD0789  [2]
 LDCM0473  CL8 HCT 116 C81(0.97)  LDD0790  [2]
 LDCM0474  CL80 HCT 116 C81(0.97)  LDD0791  [2]
 LDCM0475  CL81 HCT 116 C81(1.01)  LDD0792  [2]
 LDCM0476  CL82 HCT 116 C81(1.00)  LDD0793  [2]
 LDCM0477  CL83 HCT 116 C81(0.97)  LDD0794  [2]
 LDCM0478  CL84 HCT 116 C81(1.00)  LDD0795  [2]
 LDCM0479  CL85 HCT 116 C81(1.00)  LDD0796  [2]
 LDCM0480  CL86 HCT 116 C81(1.03)  LDD0797  [2]
 LDCM0481  CL87 HCT 116 C81(0.92)  LDD0798  [2]
 LDCM0482  CL88 HCT 116 C81(1.07)  LDD0799  [2]
 LDCM0483  CL89 HCT 116 C81(1.02)  LDD0800  [2]
 LDCM0484  CL9 HCT 116 C81(1.06)  LDD0801  [2]
 LDCM0485  CL90 HCT 116 C81(1.14)  LDD0802  [2]
 LDCM0486  CL91 HCT 116 C81(1.12)  LDD0803  [2]
 LDCM0487  CL92 HCT 116 C81(0.99)  LDD0804  [2]
 LDCM0488  CL93 HCT 116 C81(0.89)  LDD0805  [2]
 LDCM0489  CL94 HCT 116 C81(0.73)  LDD0806  [2]
 LDCM0490  CL95 HCT 116 C81(0.82)  LDD0807  [2]
 LDCM0491  CL96 HCT 116 C81(0.99)  LDD0808  [2]
 LDCM0492  CL97 HCT 116 C81(0.93)  LDD0809  [2]
 LDCM0493  CL98 HCT 116 C81(0.86)  LDD0810  [2]
 LDCM0494  CL99 HCT 116 C81(0.87)  LDD0811  [2]
 LDCM0495  E2913 HEK-293T C5(1.13); C332(1.10)  LDD1698  [7]
 LDCM0468  Fragment33 HEK-293T C5(0.93); C332(1.10)  LDD1671  [7]
 LDCM0022  KB02 HEK-293T C5(1.00)  LDD1492  [7]
 LDCM0023  KB03 HEK-293T C5(1.06)  LDD1497  [7]
 LDCM0024  KB05 HEK-293T C5(1.01)  LDD1502  [7]
 LDCM0542  Nucleophilic fragment 37 MDA-MB-231 C5(1.11)  LDD2135  [1]

References

1 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
2 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
3 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
4 Benchmarking Cleavable Biotin Tags for Peptide-Centric Chemoproteomics. J Proteome Res. 2022 May 6;21(5):1349-1358. doi: 10.1021/acs.jproteome.2c00174. Epub 2022 Apr 25.
Mass spectrometry data entry: PXD031019
5 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
6 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
7 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402