Details of the Target

General Information of Target

Target ID LDTP03881
Target Name Interleukin-6 receptor subunit beta (IL6ST)
Gene Name IL6ST
Gene ID 3572
Synonyms
Interleukin-6 receptor subunit beta; IL-6 receptor subunit beta; IL-6R subunit beta; IL-6R-beta; IL-6RB; CDw130; Interleukin-6 signal transducer; Membrane glycoprotein 130; gp130; Oncostatin-M receptor subunit alpha; CD antigen CD130
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MLTLQTWLVQALFIFLTTESTGELLDPCGYISPESPVVQLHSNFTAVCVLKEKCMDYFHV
NANYIVWKTNHFTIPKEQYTIINRTASSVTFTDIASLNIQLTCNILTFGQLEQNVYGITI
ISGLPPEKPKNLSCIVNEGKKMRCEWDGGRETHLETNFTLKSEWATHKFADCKAKRDTPT
SCTVDYSTVYFVNIEVWVEAENALGKVTSDHINFDPVYKVKPNPPHNLSVINSEELSSIL
KLTWTNPSIKSVIILKYNIQYRTKDASTWSQIPPEDTASTRSSFTVQDLKPFTEYVFRIR
CMKEDGKGYWSDWSEEASGITYEDRPSKAPSFWYKIDPSHTQGYRTVQLVWKTLPPFEAN
GKILDYEVTLTRWKSHLQNYTVNATKLTVNLTNDRYLATLTVRNLVGKSDAAVLTIPACD
FQATHPVMDLKAFPKDNMLWVEWTTPRESVKKYILEWCVLSDKAPCITDWQQEDGTVHRT
YLRGNLAESKCYLITVTPVYADGPGSPESIKAYLKQAPPSKGPTVRTKKVGKNEAVLEWD
QLPVDVQNGFIRNYTIFYRTIIGNETAVNVDSSHTEYTLSSLTSDTLYMVRMAAYTDEGG
KDGPEFTFTTPKFAQGEIEAIVVPVCLAFLLTTLLGVLFCFNKRDLIKKHIWPNVPDPSK
SHIAQWSPHTPPRHNFNSKDQMYSDGNFTDVSVVEIEANDKKPFPEDLKSLDLFKKEKIN
TEGHSSGIGGSSCMSSSRPSISSSDENESSQNTSSTVQYSTVVHSGYRHQVPSVQVFSRS
ESTQPLLDSEERPEDLQLVDHVDGGDGILPRQQYFKQNCSQHESSPDISHFERSKQVSSV
NEEDFVRLKQQISDHISQSCGSGQMKMFQEVSAADAFGPGTEGQVERFETVGMEAATDEG
MPKSYLPQTVRQGGYMPQ
Target Bioclass
Cytokine and receptor
Family
Type I cytokine receptor family, Type 2 subfamily
Subcellular location
Secreted; Cell membrane
Function
Signal-transducing molecule. The receptor systems for IL6, LIF, OSM, CNTF, IL11, CTF1 and BSF3 can utilize IL6ST for initiating signal transmission. Binding of IL6 to IL6R induces IL6ST homodimerization and formation of a high-affinity receptor complex, which activates the intracellular JAK-MAPK and JAK-STAT3 signaling pathways. That causes phosphorylation of IL6ST tyrosine residues which in turn activates STAT3. In parallel, the IL6 signaling pathway induces the expression of two cytokine receptor signaling inhibitors, SOCS1 and SOCS3, which inhibit JAK and terminate the activity of the IL6 signaling pathway as a negative feedback loop. Also activates the yes-associated protein 1 (YAP) and NOTCH pathways to control inflammation-induced epithelial regeneration, independently of STAT3. Acts as a receptor for the neuroprotective peptide humanin as part of a complex with IL27RA/WSX1 and CNTFR. Mediates signals which regulate immune response, hematopoiesis, pain control and bone metabolism. Has a role in embryonic development. Essential for survival of motor and sensory neurons and for differentiation of astrocytes. Required for expression of TRPA1 in nociceptive neurons. Required for the maintenance of PTH1R expression in the osteoblast lineage and for the stimulation of PTH-induced osteoblast differentiation. Required for normal trabecular bone mass and cortical bone composition.; [Isoform 2]: Binds to the soluble IL6:sIL6R complex (hyper-IL6), thereby blocking IL6 trans-signaling. Inhibits sIL6R-dependent acute phase response. Also blocks IL11 cluster signaling through IL11R.
Uniprot ID
P40189
Ensemble ID
ENST00000381294.8
HGNC ID
HGNC:6021
ChEMBL ID
CHEMBL3124734

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
22RV1 SNV: p.A620T .
A3KAW SNV: p.G308E .
CCK81 SNV: p.V776A .
HCT15 SNV: p.P273L .
HEC1B SNV: p.P426H .
KU1919 SNV: p.V192G .
NCIH716 SNV: p.M867T .
SISO SNV: p.I135L .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 10 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
STPyne
 Probe Info  		K715(9.87)  LDD0277  [1]
OPA-S-S-alkyne
 Probe Info  		K335(0.69)  LDD3494  [2]
m-APA
 Probe Info  		12.11  LDD0403  [3]
DBIA
 Probe Info  		C419(1.87)  LDD3314  [4]
BTD
 Probe Info  		C48(1.87)  LDD1700  [5]
NAIA_4
 Probe Info  		C819(0.00); C860(0.00)  LDD2226  [6]
WYneN
 Probe Info  		C819(0.00); C860(0.00)  LDD0021  [7]
IPM
 Probe Info  		N.A.  LDD0147  [8]
TFBX
 Probe Info  		N.A.  LDD0148  [8]
Phosphinate-6
 Probe Info  		N.A.  LDD0018  [9]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0548  1-(4-(Benzo[d][1,3]dioxol-5-ylmethyl)piperazin-1-yl)-2-nitroethan-1-one MDA-MB-231 C733(0.76)  LDD2142  [5]
 LDCM0519  1-(6-methoxy-3,4-dihydroquinolin-1(2H)-yl)-2-nitroethan-1-one MDA-MB-231 C733(0.98); C860(0.82)  LDD2112  [5]
 LDCM0524  2-Cyano-N-(2-morpholin-4-yl-ethyl)-acetamide MDA-MB-231 C733(0.82)  LDD2117  [5]
 LDCM0558  2-Cyano-N-phenylacetamide MDA-MB-231 C733(1.03); C48(1.03)  LDD2152  [5]
 LDCM0510  3-(4-(Hydroxydiphenylmethyl)piperidin-1-yl)-3-oxopropanenitrile MDA-MB-231 C733(0.84)  LDD2103  [5]
 LDCM0214  AC1 HEK-293T C419(1.14)  LDD1507  [10]
 LDCM0215  AC10 HEK-293T C419(0.90); C134(1.05)  LDD1508  [10]
 LDCM0226  AC11 HEK-293T C419(0.91)  LDD1509  [10]
 LDCM0237  AC12 HEK-293T C419(1.00); C134(1.09); C458(0.74)  LDD1510  [10]
 LDCM0259  AC14 HEK-293T C860(1.13); C419(1.06); C134(1.11)  LDD1512  [10]
 LDCM0270  AC15 HEK-293T C860(0.96); C419(1.13); C134(1.07)  LDD1513  [10]
 LDCM0276  AC17 HEK-293T C419(0.97)  LDD1515  [10]
 LDCM0277  AC18 HEK-293T C419(0.81); C134(0.99)  LDD1516  [10]
 LDCM0278  AC19 HEK-293T C419(0.78)  LDD1517  [10]
 LDCM0279  AC2 HEK-293T C419(1.10); C134(1.00)  LDD1518  [10]
 LDCM0280  AC20 HEK-293T C419(1.00); C134(1.22); C458(0.85)  LDD1519  [10]
 LDCM0281  AC21 HEK-293T C419(1.06); C134(1.04)  LDD1520  [10]
 LDCM0282  AC22 HEK-293T C860(1.17); C419(0.95); C134(1.05)  LDD1521  [10]
 LDCM0283  AC23 HEK-293T C860(0.91); C419(0.96); C134(0.96)  LDD1522  [10]
 LDCM0284  AC24 HEK-293T C860(1.09); C419(1.09); C458(0.94); C819(0.97)  LDD1523  [10]
 LDCM0285  AC25 HEK-293T C419(1.07)  LDD1524  [10]
 LDCM0286  AC26 HEK-293T C419(0.98); C134(1.07)  LDD1525  [10]
 LDCM0287  AC27 HEK-293T C419(0.94)  LDD1526  [10]
 LDCM0288  AC28 HEK-293T C419(0.99); C134(1.01); C458(1.02)  LDD1527  [10]
 LDCM0289  AC29 HEK-293T C419(1.08); C134(1.01)  LDD1528  [10]
 LDCM0290  AC3 HEK-293T C419(0.94)  LDD1529  [10]
 LDCM0291  AC30 HEK-293T C860(0.93); C419(1.14); C134(1.06)  LDD1530  [10]
 LDCM0292  AC31 HEK-293T C860(0.89); C419(1.02); C134(1.01)  LDD1531  [10]
 LDCM0293  AC32 HEK-293T C860(1.03); C419(1.04); C458(0.88); C819(1.14)  LDD1532  [10]
 LDCM0294  AC33 HEK-293T C419(0.97)  LDD1533  [10]
 LDCM0295  AC34 HEK-293T C419(1.09); C134(1.03)  LDD1534  [10]
 LDCM0296  AC35 HEK-293T C419(1.09)  LDD1535  [10]
 LDCM0297  AC36 HEK-293T C419(1.04); C134(1.15); C458(0.89)  LDD1536  [10]
 LDCM0298  AC37 HEK-293T C419(1.02); C134(1.06)  LDD1537  [10]
 LDCM0299  AC38 HEK-293T C860(1.05); C419(1.31); C134(1.11)  LDD1538  [10]
 LDCM0300  AC39 HEK-293T C860(0.96); C419(1.11); C134(1.20)  LDD1539  [10]
 LDCM0301  AC4 HEK-293T C419(1.00); C134(1.06); C458(0.93)  LDD1540  [10]
 LDCM0302  AC40 HEK-293T C860(1.00); C419(1.03); C458(0.89); C819(0.94)  LDD1541  [10]
 LDCM0303  AC41 HEK-293T C419(1.02)  LDD1542  [10]
 LDCM0304  AC42 HEK-293T C419(0.96); C134(1.10)  LDD1543  [10]
 LDCM0305  AC43 HEK-293T C419(1.01)  LDD1544  [10]
 LDCM0306  AC44 HEK-293T C419(1.01); C134(1.10); C458(0.89)  LDD1545  [10]
 LDCM0307  AC45 HEK-293T C419(1.03); C134(1.05)  LDD1546  [10]
 LDCM0308  AC46 HEK-293T C860(1.09); C419(1.23); C134(1.27)  LDD1547  [10]
 LDCM0309  AC47 HEK-293T C860(0.89); C419(1.02); C134(1.01)  LDD1548  [10]
 LDCM0310  AC48 HEK-293T C860(0.95); C419(1.05); C458(1.11); C819(1.09)  LDD1549  [10]
 LDCM0311  AC49 HEK-293T C419(1.23)  LDD1550  [10]
 LDCM0312  AC5 HEK-293T C419(1.01); C134(1.03)  LDD1551  [10]
 LDCM0313  AC50 HEK-293T C419(0.94); C134(1.00)  LDD1552  [10]
 LDCM0314  AC51 HEK-293T C419(0.76)  LDD1553  [10]
 LDCM0315  AC52 HEK-293T C419(0.99); C134(1.21); C458(0.80)  LDD1554  [10]
 LDCM0316  AC53 HEK-293T C419(1.03); C134(1.02)  LDD1555  [10]
 LDCM0317  AC54 HEK-293T C860(0.99); C419(1.00); C134(1.21)  LDD1556  [10]
 LDCM0318  AC55 HEK-293T C860(0.81); C419(1.03); C134(1.08)  LDD1557  [10]
 LDCM0319  AC56 HEK-293T C860(1.01); C419(1.06); C458(1.01); C819(0.97)  LDD1558  [10]
 LDCM0320  AC57 HEK-293T C419(1.00)  LDD1559  [10]
 LDCM0321  AC58 HEK-293T C419(0.88); C134(1.00)  LDD1560  [10]
 LDCM0322  AC59 HEK-293T C419(0.91)  LDD1561  [10]
 LDCM0323  AC6 HEK-293T C860(1.18); C419(1.08); C134(1.07)  LDD1562  [10]
 LDCM0324  AC60 HEK-293T C419(1.00); C134(1.15); C458(0.98)  LDD1563  [10]
 LDCM0325  AC61 HEK-293T C419(1.03); C134(0.97)  LDD1564  [10]
 LDCM0326  AC62 HEK-293T C860(0.97); C419(0.89); C134(1.02)  LDD1565  [10]
 LDCM0327  AC63 HEK-293T C860(0.96); C419(0.89); C134(1.01)  LDD1566  [10]
 LDCM0328  AC64 HEK-293T C860(0.95); C419(0.92); C458(1.05); C819(0.99)  LDD1567  [10]
 LDCM0334  AC7 HEK-293T C860(1.29); C419(0.98); C134(1.05)  LDD1568  [10]
 LDCM0345  AC8 HEK-293T C860(1.00); C419(0.97); C458(1.03); C819(1.12)  LDD1569  [10]
 LDCM0520  AKOS000195272 MDA-MB-231 C733(0.93)  LDD2113  [5]
 LDCM0248  AKOS034007472 HEK-293T C419(1.07); C134(1.02)  LDD1511  [10]
 LDCM0356  AKOS034007680 HEK-293T C419(1.05)  LDD1570  [10]
 LDCM0275  AKOS034007705 HEK-293T C860(0.92); C419(1.06); C458(0.98); C819(1.05)  LDD1514  [10]
 LDCM0156  Aniline NCI-H1299 12.11  LDD0403  [3]
 LDCM0367  CL1 HEK-293T C860(0.99); C419(0.96)  LDD1571  [10]
 LDCM0368  CL10 HEK-293T C860(1.58); C419(1.55); C134(1.18)  LDD1572  [10]
 LDCM0369  CL100 HEK-293T C419(0.96)  LDD1573  [10]
 LDCM0370  CL101 HEK-293T C860(1.03); C419(0.97)  LDD1574  [10]
 LDCM0371  CL102 HEK-293T C733(1.26); C860(0.79); C419(1.48); C134(1.01)  LDD1575  [10]
 LDCM0372  CL103 HEK-293T C419(0.98)  LDD1576  [10]
 LDCM0373  CL104 HEK-293T C419(0.87)  LDD1577  [10]
 LDCM0374  CL105 HEK-293T C860(1.03); C419(0.99)  LDD1578  [10]
 LDCM0375  CL106 HEK-293T C733(1.26); C860(1.08); C419(1.07); C134(0.98)  LDD1579  [10]
 LDCM0376  CL107 HEK-293T C419(1.01)  LDD1580  [10]
 LDCM0377  CL108 HEK-293T C419(1.00)  LDD1581  [10]
 LDCM0378  CL109 HEK-293T C860(0.88); C419(0.88)  LDD1582  [10]
 LDCM0379  CL11 HEK-293T C860(0.98); C419(1.18); C134(1.27)  LDD1583  [10]
 LDCM0380  CL110 HEK-293T C733(1.16); C860(0.87); C419(0.99); C134(1.04)  LDD1584  [10]
 LDCM0381  CL111 HEK-293T C419(0.93)  LDD1585  [10]
 LDCM0382  CL112 HEK-293T C419(1.00)  LDD1586  [10]
 LDCM0383  CL113 HEK-293T C860(0.97); C419(0.97)  LDD1587  [10]
 LDCM0384  CL114 HEK-293T C733(1.20); C860(1.06); C419(1.14); C134(1.01)  LDD1588  [10]
 LDCM0385  CL115 HEK-293T C419(0.99)  LDD1589  [10]
 LDCM0386  CL116 HEK-293T C419(1.02)  LDD1590  [10]
 LDCM0387  CL117 HEK-293T C860(0.94); C419(0.99)  LDD1591  [10]
 LDCM0388  CL118 HEK-293T C733(1.41); C860(0.93); C419(1.00); C134(1.07)  LDD1592  [10]
 LDCM0389  CL119 HEK-293T C419(0.88)  LDD1593  [10]
 LDCM0390  CL12 HEK-293T C860(0.94); C419(1.37); C458(0.95); C819(0.96)  LDD1594  [10]
 LDCM0391  CL120 HEK-293T C419(0.98)  LDD1595  [10]
 LDCM0392  CL121 HEK-293T C860(0.87); C419(0.94)  LDD1596  [10]
 LDCM0393  CL122 HEK-293T C733(1.11); C860(0.94); C419(1.13); C134(0.97)  LDD1597  [10]
 LDCM0394  CL123 HEK-293T C419(1.02)  LDD1598  [10]
 LDCM0395  CL124 HEK-293T C419(0.98)  LDD1599  [10]
 LDCM0396  CL125 HEK-293T C860(0.82); C419(1.00)  LDD1600  [10]
 LDCM0397  CL126 HEK-293T C733(0.77); C860(0.88); C419(1.06); C134(0.95)  LDD1601  [10]
 LDCM0398  CL127 HEK-293T C419(1.03)  LDD1602  [10]
 LDCM0399  CL128 HEK-293T C419(0.97)  LDD1603  [10]
 LDCM0400  CL13 HEK-293T C860(0.93); C419(1.07)  LDD1604  [10]
 LDCM0401  CL14 HEK-293T C733(1.25); C860(0.75); C419(1.22); C134(1.03)  LDD1605  [10]
 LDCM0402  CL15 HEK-293T C419(0.89)  LDD1606  [10]
 LDCM0403  CL16 HEK-293T C419(1.03)  LDD1607  [10]
 LDCM0404  CL17 HEK-293T C419(1.09)  LDD1608  [10]
 LDCM0405  CL18 HEK-293T C419(1.12); C134(1.09)  LDD1609  [10]
 LDCM0406  CL19 HEK-293T C419(1.06)  LDD1610  [10]
 LDCM0407  CL2 HEK-293T C733(1.17); C860(0.77); C419(1.44); C134(1.03)  LDD1611  [10]
 LDCM0408  CL20 HEK-293T C419(1.06); C134(1.30); C458(0.83)  LDD1612  [10]
 LDCM0409  CL21 HEK-293T C419(1.20); C134(1.31)  LDD1613  [10]
 LDCM0410  CL22 HEK-293T C860(1.04); C419(1.10); C134(1.35)  LDD1614  [10]
 LDCM0411  CL23 HEK-293T C860(0.85); C419(1.25); C134(1.32)  LDD1615  [10]
 LDCM0412  CL24 HEK-293T C860(1.00); C419(1.21); C458(1.10); C819(0.82)  LDD1616  [10]
 LDCM0413  CL25 HEK-293T C860(0.84); C419(0.90)  LDD1617  [10]
 LDCM0414  CL26 HEK-293T C733(1.60); C860(1.09); C419(1.05); C134(0.97)  LDD1618  [10]
 LDCM0415  CL27 HEK-293T C419(1.01)  LDD1619  [10]
 LDCM0416  CL28 HEK-293T C419(0.99)  LDD1620  [10]
 LDCM0417  CL29 HEK-293T C419(0.99)  LDD1621  [10]
 LDCM0418  CL3 HEK-293T C419(0.94)  LDD1622  [10]
 LDCM0419  CL30 HEK-293T C419(1.04); C134(0.99)  LDD1623  [10]
 LDCM0420  CL31 HEK-293T C419(1.00)  LDD1624  [10]
 LDCM0421  CL32 HEK-293T C419(1.02); C134(1.10); C458(0.97)  LDD1625  [10]
 LDCM0422  CL33 HEK-293T C419(1.21); C134(1.31)  LDD1626  [10]
 LDCM0423  CL34 HEK-293T C860(0.88); C419(1.24); C134(1.24)  LDD1627  [10]
 LDCM0424  CL35 HEK-293T C860(0.91); C419(1.14); C134(1.30)  LDD1628  [10]
 LDCM0425  CL36 HEK-293T C860(0.95); C419(1.31); C458(1.33); C819(0.89)  LDD1629  [10]
 LDCM0426  CL37 HEK-293T C860(0.91); C419(0.95)  LDD1630  [10]
 LDCM0428  CL39 HEK-293T C419(1.00)  LDD1632  [10]
 LDCM0429  CL4 HEK-293T C419(0.94)  LDD1633  [10]
 LDCM0430  CL40 HEK-293T C419(0.97)  LDD1634  [10]
 LDCM0431  CL41 HEK-293T C419(1.48)  LDD1635  [10]
 LDCM0432  CL42 HEK-293T C419(1.06); C134(1.01)  LDD1636  [10]
 LDCM0433  CL43 HEK-293T C419(1.34)  LDD1637  [10]
 LDCM0434  CL44 HEK-293T C419(0.95); C134(1.16); C458(0.78)  LDD1638  [10]
 LDCM0435  CL45 HEK-293T C419(1.27); C134(1.30)  LDD1639  [10]
 LDCM0436  CL46 HEK-293T C860(1.17); C419(1.13); C134(1.17)  LDD1640  [10]
 LDCM0437  CL47 HEK-293T C860(0.85); C419(1.27); C134(1.26)  LDD1641  [10]
 LDCM0438  CL48 HEK-293T C860(1.01); C419(1.22); C458(0.95); C819(0.91)  LDD1642  [10]
 LDCM0439  CL49 HEK-293T C860(0.91); C419(1.04)  LDD1643  [10]
 LDCM0440  CL5 HEK-293T C419(1.42)  LDD1644  [10]
 LDCM0441  CL50 HEK-293T C733(1.13); C860(1.05); C419(1.07); C134(0.98)  LDD1645  [10]
 LDCM0443  CL52 HEK-293T C419(0.99)  LDD1646  [10]
 LDCM0444  CL53 HEK-293T C419(1.15)  LDD1647  [10]
 LDCM0445  CL54 HEK-293T C419(1.19); C134(1.12)  LDD1648  [10]
 LDCM0446  CL55 HEK-293T C419(0.93)  LDD1649  [10]
 LDCM0447  CL56 HEK-293T C419(1.04); C134(1.32); C458(0.94)  LDD1650  [10]
 LDCM0448  CL57 HEK-293T C419(1.39); C134(1.20)  LDD1651  [10]
 LDCM0449  CL58 HEK-293T C860(0.84); C419(1.24); C134(1.20)  LDD1652  [10]
 LDCM0450  CL59 HEK-293T C860(0.78); C419(1.12); C134(1.14)  LDD1653  [10]
 LDCM0451  CL6 HEK-293T C419(1.18); C134(1.02)  LDD1654  [10]
 LDCM0452  CL60 HEK-293T C860(1.10); C419(1.26); C458(1.13); C819(0.94)  LDD1655  [10]
 LDCM0453  CL61 HEK-293T C860(0.91); C419(0.91)  LDD1656  [10]
 LDCM0454  CL62 HEK-293T C733(1.50); C860(1.06); C419(1.13); C134(1.03)  LDD1657  [10]
 LDCM0455  CL63 HEK-293T C419(1.04)  LDD1658  [10]
 LDCM0456  CL64 HEK-293T C419(0.94)  LDD1659  [10]
 LDCM0457  CL65 HEK-293T C419(1.11)  LDD1660  [10]
 LDCM0458  CL66 HEK-293T C419(1.01); C134(1.02)  LDD1661  [10]
 LDCM0459  CL67 HEK-293T C419(1.11)  LDD1662  [10]
 LDCM0460  CL68 HEK-293T C419(1.04); C134(1.21); C458(0.86)  LDD1663  [10]
 LDCM0461  CL69 HEK-293T C419(1.22); C134(1.19)  LDD1664  [10]
 LDCM0462  CL7 HEK-293T C419(0.87)  LDD1665  [10]
 LDCM0463  CL70 HEK-293T C860(1.06); C419(1.19); C134(1.16)  LDD1666  [10]
 LDCM0464  CL71 HEK-293T C860(0.71); C419(1.13); C134(1.38)  LDD1667  [10]
 LDCM0465  CL72 HEK-293T C860(1.07); C419(1.28); C458(1.14); C819(1.03)  LDD1668  [10]
 LDCM0466  CL73 HEK-293T C860(0.81); C419(0.94)  LDD1669  [10]
 LDCM0467  CL74 HEK-293T C733(0.87); C860(0.95); C419(1.05); C134(0.96)  LDD1670  [10]
 LDCM0469  CL76 HEK-293T C419(1.01)  LDD1672  [10]
 LDCM0470  CL77 HEK-293T C419(0.98)  LDD1673  [10]
 LDCM0471  CL78 HEK-293T C419(0.99); C134(1.00)  LDD1674  [10]
 LDCM0472  CL79 HEK-293T C419(0.98)  LDD1675  [10]
 LDCM0473  CL8 HEK-293T C419(1.24); C134(1.24); C458(1.05)  LDD1676  [10]
 LDCM0474  CL80 HEK-293T C419(1.05); C134(1.18); C458(0.99)  LDD1677  [10]
 LDCM0475  CL81 HEK-293T C419(1.20); C134(1.09)  LDD1678  [10]
 LDCM0476  CL82 HEK-293T C860(0.92); C419(1.13); C134(1.18)  LDD1679  [10]
 LDCM0477  CL83 HEK-293T C860(0.73); C419(1.08); C134(1.21)  LDD1680  [10]
 LDCM0478  CL84 HEK-293T C860(0.92); C419(1.15); C458(1.02); C819(0.98)  LDD1681  [10]
 LDCM0479  CL85 HEK-293T C860(0.82); C419(0.95)  LDD1682  [10]
 LDCM0480  CL86 HEK-293T C733(0.76); C860(0.65); C419(0.95); C134(0.98)  LDD1683  [10]
 LDCM0481  CL87 HEK-293T C419(1.20)  LDD1684  [10]
 LDCM0482  CL88 HEK-293T C419(1.15)  LDD1685  [10]
 LDCM0483  CL89 HEK-293T C419(1.19)  LDD1686  [10]
 LDCM0484  CL9 HEK-293T C419(1.18); C134(1.11)  LDD1687  [10]
 LDCM0485  CL90 HEK-293T C419(1.04); C134(1.09)  LDD1688  [10]
 LDCM0486  CL91 HEK-293T C419(0.74)  LDD1689  [10]
 LDCM0487  CL92 HEK-293T C419(1.06); C134(1.00); C458(1.06)  LDD1690  [10]
 LDCM0488  CL93 HEK-293T C419(1.24); C134(1.10)  LDD1691  [10]
 LDCM0489  CL94 HEK-293T C860(0.97); C419(1.03); C134(0.92)  LDD1692  [10]
 LDCM0490  CL95 HEK-293T C860(0.89); C419(1.32); C134(1.21)  LDD1693  [10]
 LDCM0491  CL96 HEK-293T C860(0.81); C419(1.09); C458(1.12); C819(0.70)  LDD1694  [10]
 LDCM0492  CL97 HEK-293T C860(1.00); C419(1.13)  LDD1695  [10]
 LDCM0493  CL98 HEK-293T C733(1.25); C860(1.12); C419(0.95); C134(0.94)  LDD1696  [10]
 LDCM0494  CL99 HEK-293T C419(1.08)  LDD1697  [10]
 LDCM0495  E2913 HEK-293T C419(0.90)  LDD1698  [10]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C860(3.96); C733(1.75); C466(1.33); C48(1.28)  LDD1702  [5]
 LDCM0468  Fragment33 HEK-293T C419(1.00)  LDD1671  [10]
 LDCM0427  Fragment51 HEK-293T C733(1.08); C860(1.13); C419(1.21); C134(1.04)  LDD1631  [10]
 LDCM0022  KB02 HEK-293T C419(0.98); C860(0.88)  LDD1492  [10]
 LDCM0023  KB03 HEK-293T C419(1.06); C860(0.81)  LDD1497  [10]
 LDCM0024  KB05 IGR37 C419(1.87)  LDD3314  [4]
 LDCM0509  N-(4-bromo-3,5-dimethylphenyl)-2-nitroacetamide MDA-MB-231 C733(0.80)  LDD2102  [5]
 LDCM0528  N-(4-bromophenyl)-2-cyano-N-phenylacetamide MDA-MB-231 C48(0.67)  LDD2121  [5]
 LDCM0497  Nucleophilic fragment 11b MDA-MB-231 C860(1.33)  LDD2090  [5]
 LDCM0499  Nucleophilic fragment 12b MDA-MB-231 C733(0.77); C860(0.93)  LDD2092  [5]
 LDCM0500  Nucleophilic fragment 13a MDA-MB-231 C733(0.94)  LDD2093  [5]
 LDCM0501  Nucleophilic fragment 13b MDA-MB-231 C733(1.01); C860(1.11)  LDD2094  [5]
 LDCM0505  Nucleophilic fragment 15b MDA-MB-231 C733(0.71); C860(0.77)  LDD2098  [5]
 LDCM0506  Nucleophilic fragment 16a MDA-MB-231 C733(0.66); C48(0.91)  LDD2099  [5]
 LDCM0507  Nucleophilic fragment 16b MDA-MB-231 C733(0.87); C860(0.65); C48(0.16)  LDD2100  [5]
 LDCM0511  Nucleophilic fragment 18b MDA-MB-231 C733(0.83); C860(0.71)  LDD2104  [5]
 LDCM0512  Nucleophilic fragment 19a MDA-MB-231 C733(1.27); C860(1.34)  LDD2105  [5]
 LDCM0513  Nucleophilic fragment 19b MDA-MB-231 C733(0.79)  LDD2106  [5]
 LDCM0514  Nucleophilic fragment 20a MDA-MB-231 C733(1.00); C48(0.85)  LDD2107  [5]
 LDCM0515  Nucleophilic fragment 20b MDA-MB-231 C733(0.85); C819(0.53)  LDD2108  [5]
 LDCM0516  Nucleophilic fragment 21a MDA-MB-231 C860(0.90); C48(0.40)  LDD2109  [5]
 LDCM0517  Nucleophilic fragment 21b MDA-MB-231 C733(1.53); C860(0.99)  LDD2110  [5]
 LDCM0518  Nucleophilic fragment 22a MDA-MB-231 C733(0.81)  LDD2111  [5]
 LDCM0521  Nucleophilic fragment 23b MDA-MB-231 C733(0.91); C860(0.78)  LDD2114  [5]
 LDCM0526  Nucleophilic fragment 26a MDA-MB-231 C733(2.45); C48(1.85)  LDD2119  [5]
 LDCM0530  Nucleophilic fragment 28a MDA-MB-231 C733(0.99); C48(0.64)  LDD2123  [5]
 LDCM0532  Nucleophilic fragment 29a MDA-MB-231 C733(0.80); C48(0.69)  LDD2125  [5]
 LDCM0534  Nucleophilic fragment 30a MDA-MB-231 C733(1.27)  LDD2127  [5]
 LDCM0536  Nucleophilic fragment 31 MDA-MB-231 C733(1.15); C860(0.97); C48(0.90)  LDD2129  [5]
 LDCM0540  Nucleophilic fragment 35 MDA-MB-231 C48(0.94)  LDD2133  [5]
 LDCM0541  Nucleophilic fragment 36 MDA-MB-231 C733(0.76); C48(0.71)  LDD2134  [5]
 LDCM0542  Nucleophilic fragment 37 MDA-MB-231 C733(0.98); C48(1.32)  LDD2135  [5]
 LDCM0543  Nucleophilic fragment 38 MDA-MB-231 C733(1.02); C860(1.72); C48(0.59)  LDD2136  [5]
 LDCM0544  Nucleophilic fragment 39 MDA-MB-231 C733(1.00); C860(0.95); C48(0.66)  LDD2137  [5]
 LDCM0211  Nucleophilic fragment 3b MDA-MB-231 C48(1.87)  LDD1700  [5]
 LDCM0546  Nucleophilic fragment 40 MDA-MB-231 C733(1.08); C48(0.52)  LDD2140  [5]
 LDCM0547  Nucleophilic fragment 41 MDA-MB-231 C733(0.61); C860(0.64); C419(0.82)  LDD2141  [5]
 LDCM0550  Nucleophilic fragment 5a MDA-MB-231 C733(2.19); C48(2.21)  LDD2144  [5]
 LDCM0551  Nucleophilic fragment 5b MDA-MB-231 C733(6.62); C48(0.14)  LDD2145  [5]
 LDCM0552  Nucleophilic fragment 6a MDA-MB-231 C733(0.86); C48(0.71)  LDD2146  [5]
 LDCM0559  Nucleophilic fragment 9b MDA-MB-231 C733(1.54)  LDD2153  [5]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Tyrosine-protein kinase JAK1 (JAK1) Tyr protein kinase family P23458
Transporter and channel
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Calsenilin (KCNIP3) Recoverin family Q9Y2W7
Cytokine and receptor
Click To Hide/Show 5 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Ciliary neurotrophic factor (CNTF) CNTF family P26441
Leukemia inhibitory factor (LIF) LIF/OSM family P15018
Oncostatin-M (OSM) LIF/OSM family P13725
Interleukin-6 receptor subunit beta (IL6ST) Type I cytokine receptor family P40189
Oncostatin-M-specific receptor subunit beta (OSMR) Type I cytokine receptor family Q99650
Other
Click To Hide/Show 3 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Small glutamine-rich tetratricopeptide repeat-containing protein alpha (SGTA) SGT family O43765
Small glutamine-rich tetratricopeptide repeat-containing protein beta (SGTB) SGT family Q96EQ0
Melanoma-associated antigen 11 (MAGEA11) . P43364

References

1 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
2 A chemical proteomics approach for global mapping of functional lysines on cell surface of living cell. Nat Commun. 2024 Apr 8;15(1):2997. doi: 10.1038/s41467-024-47033-w.
Mass spectrometry data entry: PXD042888
3 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
4 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
5 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
6 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
7 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
8 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
9 DFT-Guided Discovery of Ethynyl-Triazolyl-Phosphinates as Modular Electrophiles for Chemoselective Cysteine Bioconjugation and Profiling. Angew Chem Int Ed Engl. 2022 Oct 10;61(41):e202205348. doi: 10.1002/anie.202205348. Epub 2022 Aug 22.
Mass spectrometry data entry: PXD033004
10 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402