Details of the Target

General Information of Target

Target ID LDTP03362
Target Name Alpha-1,3-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase (MGAT1)
Gene Name MGAT1
Gene ID 4245
Synonyms
GGNT1; GLCT1; GLYT1; MGAT; Alpha-1,3-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase; EC 2.4.1.101; N-glycosyl-oligosaccharide-glycoprotein N-acetylglucosaminyltransferase I; GNT-I; GlcNAc-T I
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MLKKQSAGLVLWGAILFVAWNALLLLFFWTRPAPGRPPSVSALDGDPASLTREVIRLAQD
AEVELERQRGLLQQIGDALSSQRGRVPTAAPPAQPRVPVTPAPAVIPILVIACDRSTVRR
CLDKLLHYRPSAELFPIIVSQDCGHEETAQAIASYGSAVTHIRQPDLSSIAVPPDHRKFQ
GYYKIARHYRWALGQVFRQFRFPAAVVVEDDLEVAPDFFEYFRATYPLLKADPSLWCVSA
WNDNGKEQMVDASRPELLYRTDFFPGLGWLLLAELWAELEPKWPKAFWDDWMRRPEQRQG
RACIRPEISRTMTFGRKGVSHGQFFDQHLKFIKLNQQFVHFTQLDLSYLQREAYDRDFLA
RVYGAPQLQVEKVRTNDRKELGEVRVQYTGRDSFKAFAKALGVMDDLKSGVPRAGYRGIV
TFQFRGRRVHLAPPLTWEGYDPSWN
Target Type
Patented-recorded
Target Bioclass
Enzyme
Family
Glycosyltransferase 13 family
Subcellular location
Golgi apparatus membrane
Function Initiates complex N-linked carbohydrate formation. Essential for the conversion of high-mannose to hybrid and complex N-glycans.
TTD ID
T90751
Uniprot ID
P26572
DrugMap ID
TTYJRN5
Ensemble ID
ENST00000307826.5
HGNC ID
HGNC:7044
ChEMBL ID
CHEMBL2375207

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 7 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
YN-1
 Probe Info  		100.00  LDD0444  [1]
DBIA
 Probe Info  		C303(3.62)  LDD3427  [2]
BTD
 Probe Info  		C303(2.40)  LDD1700  [3]
IPM
 Probe Info  		C303(5.20)  LDD1701  [3]
ATP probe
 Probe Info  		K317(0.00); K330(0.00); K333(0.00)  LDD0199  [4]
Lodoacetamide azide
 Probe Info  		N.A.  LDD0037  [5]
NAIA_5
 Probe Info  		C303(0.00); C143(0.00)  LDD2223  [6]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0524  2-Cyano-N-(2-morpholin-4-yl-ethyl)-acetamide MDA-MB-231 C303(0.94)  LDD2117  [3]
 LDCM0539  3-(4-Isopropylpiperazin-1-yl)-3-oxopropanenitrile MDA-MB-231 C303(0.43)  LDD2132  [3]
 LDCM0214  AC1 PaTu 8988t C237(0.16)  LDD1093  [7]
 LDCM0215  AC10 HEK-293T C303(1.04)  LDD1508  [8]
 LDCM0226  AC11 HEK-293T C303(1.00)  LDD1509  [8]
 LDCM0237  AC12 HEK-293T C303(0.99)  LDD1510  [8]
 LDCM0259  AC14 HEK-293T C303(0.98)  LDD1512  [8]
 LDCM0263  AC143 PaTu 8988t C237(0.57)  LDD1142  [7]
 LDCM0264  AC144 PaTu 8988t C237(0.72)  LDD1143  [7]
 LDCM0265  AC145 PaTu 8988t C237(0.78)  LDD1144  [7]
 LDCM0266  AC146 PaTu 8988t C237(1.11)  LDD1145  [7]
 LDCM0267  AC147 PaTu 8988t C237(0.86)  LDD1146  [7]
 LDCM0268  AC148 PaTu 8988t C237(0.57)  LDD1147  [7]
 LDCM0269  AC149 PaTu 8988t C237(0.62)  LDD1148  [7]
 LDCM0270  AC15 HEK-293T C303(1.00)  LDD1513  [8]
 LDCM0271  AC150 PaTu 8988t C237(0.87)  LDD1150  [7]
 LDCM0272  AC151 PaTu 8988t C237(0.73)  LDD1151  [7]
 LDCM0273  AC152 PaTu 8988t C237(0.75)  LDD1152  [7]
 LDCM0274  AC153 PaTu 8988t C237(0.72)  LDD1153  [7]
 LDCM0621  AC154 PaTu 8988t C237(0.88)  LDD2166  [7]
 LDCM0622  AC155 PaTu 8988t C237(0.70)  LDD2167  [7]
 LDCM0623  AC156 PaTu 8988t C237(0.68)  LDD2168  [7]
 LDCM0624  AC157 PaTu 8988t C237(0.86)  LDD2169  [7]
 LDCM0276  AC17 HEK-293T C303(1.02)  LDD1515  [8]
 LDCM0277  AC18 HEK-293T C303(1.00)  LDD1516  [8]
 LDCM0278  AC19 HEK-293T C303(1.15)  LDD1517  [8]
 LDCM0279  AC2 PaTu 8988t C237(0.27)  LDD1158  [7]
 LDCM0280  AC20 HEK-293T C303(0.99)  LDD1519  [8]
 LDCM0281  AC21 HEK-293T C303(1.05)  LDD1520  [8]
 LDCM0282  AC22 HEK-293T C303(0.97)  LDD1521  [8]
 LDCM0283  AC23 HEK-293T C303(0.98)  LDD1522  [8]
 LDCM0284  AC24 HEK-293T C303(0.99)  LDD1523  [8]
 LDCM0285  AC25 PaTu 8988t C237(1.29)  LDD1164  [7]
 LDCM0286  AC26 PaTu 8988t C237(1.07)  LDD1165  [7]
 LDCM0287  AC27 PaTu 8988t C237(1.22)  LDD1166  [7]
 LDCM0288  AC28 PaTu 8988t C237(1.05)  LDD1167  [7]
 LDCM0289  AC29 PaTu 8988t C237(1.07)  LDD1168  [7]
 LDCM0290  AC3 PaTu 8988t C237(0.20)  LDD1169  [7]
 LDCM0291  AC30 PaTu 8988t C237(1.08)  LDD1170  [7]
 LDCM0292  AC31 PaTu 8988t C237(1.38)  LDD1171  [7]
 LDCM0293  AC32 PaTu 8988t C237(1.00)  LDD1172  [7]
 LDCM0294  AC33 PaTu 8988t C237(0.93)  LDD1173  [7]
 LDCM0295  AC34 PaTu 8988t C237(0.79)  LDD1174  [7]
 LDCM0296  AC35 HEK-293T C303(1.03)  LDD1535  [8]
 LDCM0297  AC36 HEK-293T C303(1.00)  LDD1536  [8]
 LDCM0298  AC37 HEK-293T C303(1.02)  LDD1537  [8]
 LDCM0299  AC38 HEK-293T C303(0.97)  LDD1538  [8]
 LDCM0300  AC39 HEK-293T C303(1.01)  LDD1539  [8]
 LDCM0301  AC4 PaTu 8988t C237(0.26)  LDD1180  [7]
 LDCM0302  AC40 HEK-293T C303(1.04)  LDD1541  [8]
 LDCM0303  AC41 HEK-293T C303(1.00)  LDD1542  [8]
 LDCM0304  AC42 HEK-293T C303(1.04)  LDD1543  [8]
 LDCM0305  AC43 HEK-293T C303(0.93)  LDD1544  [8]
 LDCM0306  AC44 HEK-293T C303(1.02)  LDD1545  [8]
 LDCM0307  AC45 HEK-293T C303(1.08)  LDD1546  [8]
 LDCM0308  AC46 HEK-293T C303(1.02)  LDD1547  [8]
 LDCM0309  AC47 HEK-293T C303(1.01)  LDD1548  [8]
 LDCM0310  AC48 HEK-293T C303(0.98)  LDD1549  [8]
 LDCM0311  AC49 HEK-293T C303(0.99)  LDD1550  [8]
 LDCM0312  AC5 PaTu 8988t C237(0.18)  LDD1191  [7]
 LDCM0313  AC50 HEK-293T C303(1.00)  LDD1552  [8]
 LDCM0314  AC51 HEK-293T C303(1.00)  LDD1553  [8]
 LDCM0315  AC52 HEK-293T C303(1.01)  LDD1554  [8]
 LDCM0316  AC53 HEK-293T C303(1.00)  LDD1555  [8]
 LDCM0317  AC54 HEK-293T C303(0.99)  LDD1556  [8]
 LDCM0318  AC55 HEK-293T C303(0.98)  LDD1557  [8]
 LDCM0319  AC56 HEK-293T C303(1.00)  LDD1558  [8]
 LDCM0320  AC57 HEK-293T C303(1.04)  LDD1559  [8]
 LDCM0321  AC58 HEK-293T C303(1.02)  LDD1560  [8]
 LDCM0322  AC59 HEK-293T C303(0.94)  LDD1561  [8]
 LDCM0323  AC6 HEK-293T C303(1.03)  LDD1562  [8]
 LDCM0324  AC60 HEK-293T C303(1.02)  LDD1563  [8]
 LDCM0325  AC61 HEK-293T C303(1.06)  LDD1564  [8]
 LDCM0326  AC62 HEK-293T C303(0.98)  LDD1565  [8]
 LDCM0327  AC63 HEK-293T C303(0.95)  LDD1566  [8]
 LDCM0328  AC64 HEK-293T C303(0.97)  LDD1567  [8]
 LDCM0334  AC7 HEK-293T C303(1.01)  LDD1568  [8]
 LDCM0345  AC8 HEK-293T C303(0.99)  LDD1569  [8]
 LDCM0520  AKOS000195272 MDA-MB-231 C303(0.92)  LDD2113  [3]
 LDCM0248  AKOS034007472 HEK-293T C303(1.01)  LDD1511  [8]
 LDCM0356  AKOS034007680 HEK-293T C303(1.00)  LDD1570  [8]
 LDCM0275  AKOS034007705 HEK-293T C303(1.00)  LDD1514  [8]
 LDCM0498  BS-3668 MDA-MB-231 C303(0.62)  LDD2091  [3]
 LDCM0367  CL1 HEK-293T C303(1.26)  LDD1571  [8]
 LDCM0368  CL10 HEK-293T C303(1.46)  LDD1572  [8]
 LDCM0369  CL100 PaTu 8988t C237(0.20)  LDD1248  [7]
 LDCM0370  CL101 HEK-293T C303(1.10)  LDD1574  [8]
 LDCM0371  CL102 HEK-293T C303(1.07)  LDD1575  [8]
 LDCM0372  CL103 HEK-293T C303(1.01)  LDD1576  [8]
 LDCM0373  CL104 HEK-293T C303(1.00)  LDD1577  [8]
 LDCM0374  CL105 HEK-293T C303(1.09)  LDD1578  [8]
 LDCM0375  CL106 HEK-293T C303(0.99)  LDD1579  [8]
 LDCM0376  CL107 HEK-293T C303(1.00)  LDD1580  [8]
 LDCM0377  CL108 HEK-293T C303(1.07)  LDD1581  [8]
 LDCM0378  CL109 HEK-293T C303(1.08)  LDD1582  [8]
 LDCM0379  CL11 HEK-293T C303(1.10)  LDD1583  [8]
 LDCM0380  CL110 HEK-293T C303(1.09)  LDD1584  [8]
 LDCM0381  CL111 HEK-293T C303(0.97)  LDD1585  [8]
 LDCM0382  CL112 PaTu 8988t C237(1.23)  LDD1261  [7]
 LDCM0383  CL113 PaTu 8988t C237(1.35)  LDD1262  [7]
 LDCM0384  CL114 PaTu 8988t C237(1.15)  LDD1263  [7]
 LDCM0385  CL115 PaTu 8988t C237(1.20)  LDD1264  [7]
 LDCM0386  CL116 PaTu 8988t C237(1.34)  LDD1265  [7]
 LDCM0387  CL117 HEK-293T C303(1.08)  LDD1591  [8]
 LDCM0388  CL118 HEK-293T C303(0.94)  LDD1592  [8]
 LDCM0389  CL119 HEK-293T C303(0.95)  LDD1593  [8]
 LDCM0390  CL12 HEK-293T C303(1.10)  LDD1594  [8]
 LDCM0391  CL120 HEK-293T C303(1.05)  LDD1595  [8]
 LDCM0392  CL121 HEK-293T C303(1.07)  LDD1596  [8]
 LDCM0393  CL122 HEK-293T C303(1.04)  LDD1597  [8]
 LDCM0394  CL123 HEK-293T C303(1.12)  LDD1598  [8]
 LDCM0395  CL124 HEK-293T C303(1.01)  LDD1599  [8]
 LDCM0396  CL125 HEK-293T C303(1.06)  LDD1600  [8]
 LDCM0397  CL126 HEK-293T C303(1.02)  LDD1601  [8]
 LDCM0398  CL127 HEK-293T C303(1.02)  LDD1602  [8]
 LDCM0399  CL128 HEK-293T C303(1.06)  LDD1603  [8]
 LDCM0400  CL13 HEK-293T C303(1.20)  LDD1604  [8]
 LDCM0401  CL14 HEK-293T C303(0.96)  LDD1605  [8]
 LDCM0402  CL15 HEK-293T C303(1.13)  LDD1606  [8]
 LDCM0403  CL16 HEK-293T C303(0.97)  LDD1607  [8]
 LDCM0404  CL17 HEK-293T C303(1.21)  LDD1608  [8]
 LDCM0405  CL18 HEK-293T C303(1.01)  LDD1609  [8]
 LDCM0406  CL19 HEK-293T C303(1.04)  LDD1610  [8]
 LDCM0407  CL2 HEK-293T C303(0.97)  LDD1611  [8]
 LDCM0408  CL20 HEK-293T C303(1.03)  LDD1612  [8]
 LDCM0409  CL21 HEK-293T C303(1.21)  LDD1613  [8]
 LDCM0410  CL22 HEK-293T C303(1.02)  LDD1614  [8]
 LDCM0411  CL23 HEK-293T C303(1.02)  LDD1615  [8]
 LDCM0412  CL24 HEK-293T C303(1.09)  LDD1616  [8]
 LDCM0413  CL25 HEK-293T C303(1.11)  LDD1617  [8]
 LDCM0414  CL26 HEK-293T C303(0.92)  LDD1618  [8]
 LDCM0415  CL27 HEK-293T C303(1.05)  LDD1619  [8]
 LDCM0416  CL28 HEK-293T C303(1.10)  LDD1620  [8]
 LDCM0417  CL29 HEK-293T C303(0.94)  LDD1621  [8]
 LDCM0418  CL3 HEK-293T C303(1.01)  LDD1622  [8]
 LDCM0419  CL30 HEK-293T C303(1.00)  LDD1623  [8]
 LDCM0420  CL31 HEK-293T C303(1.02)  LDD1624  [8]
 LDCM0421  CL32 HEK-293T C303(1.07)  LDD1625  [8]
 LDCM0422  CL33 HEK-293T C303(1.38)  LDD1626  [8]
 LDCM0423  CL34 HEK-293T C303(1.08)  LDD1627  [8]
 LDCM0424  CL35 HEK-293T C303(1.04)  LDD1628  [8]
 LDCM0425  CL36 HEK-293T C303(1.13)  LDD1629  [8]
 LDCM0426  CL37 HEK-293T C303(1.00)  LDD1630  [8]
 LDCM0428  CL39 HEK-293T C303(1.07)  LDD1632  [8]
 LDCM0429  CL4 HEK-293T C303(1.07)  LDD1633  [8]
 LDCM0430  CL40 HEK-293T C303(0.99)  LDD1634  [8]
 LDCM0431  CL41 HEK-293T C303(1.05)  LDD1635  [8]
 LDCM0432  CL42 HEK-293T C303(1.01)  LDD1636  [8]
 LDCM0433  CL43 HEK-293T C303(0.98)  LDD1637  [8]
 LDCM0434  CL44 HEK-293T C303(1.09)  LDD1638  [8]
 LDCM0435  CL45 HEK-293T C303(1.23)  LDD1639  [8]
 LDCM0436  CL46 HEK-293T C303(1.02)  LDD1640  [8]
 LDCM0437  CL47 HEK-293T C303(1.09)  LDD1641  [8]
 LDCM0438  CL48 HEK-293T C303(1.10)  LDD1642  [8]
 LDCM0439  CL49 HEK-293T C303(1.10)  LDD1643  [8]
 LDCM0440  CL5 HEK-293T C303(1.05)  LDD1644  [8]
 LDCM0441  CL50 HEK-293T C303(0.97)  LDD1645  [8]
 LDCM0443  CL52 HEK-293T C303(1.09)  LDD1646  [8]
 LDCM0444  CL53 HEK-293T C303(1.09)  LDD1647  [8]
 LDCM0445  CL54 HEK-293T C303(1.13)  LDD1648  [8]
 LDCM0446  CL55 HEK-293T C303(1.02)  LDD1649  [8]
 LDCM0447  CL56 HEK-293T C303(1.15)  LDD1650  [8]
 LDCM0448  CL57 HEK-293T C303(1.36)  LDD1651  [8]
 LDCM0449  CL58 HEK-293T C303(1.10)  LDD1652  [8]
 LDCM0450  CL59 HEK-293T C303(1.09)  LDD1653  [8]
 LDCM0451  CL6 HEK-293T C303(1.07)  LDD1654  [8]
 LDCM0452  CL60 HEK-293T C303(1.17)  LDD1655  [8]
 LDCM0453  CL61 HEK-293T C303(1.04)  LDD1656  [8]
 LDCM0454  CL62 HEK-293T C303(0.94)  LDD1657  [8]
 LDCM0455  CL63 HEK-293T C303(0.96)  LDD1658  [8]
 LDCM0456  CL64 HEK-293T C303(1.09)  LDD1659  [8]
 LDCM0457  CL65 HEK-293T C303(1.05)  LDD1660  [8]
 LDCM0458  CL66 HEK-293T C303(1.03)  LDD1661  [8]
 LDCM0459  CL67 HEK-293T C303(1.04)  LDD1662  [8]
 LDCM0460  CL68 HEK-293T C303(1.10)  LDD1663  [8]
 LDCM0461  CL69 HEK-293T C303(1.09)  LDD1664  [8]
 LDCM0462  CL7 HEK-293T C303(1.00)  LDD1665  [8]
 LDCM0463  CL70 HEK-293T C303(1.00)  LDD1666  [8]
 LDCM0464  CL71 HEK-293T C303(1.07)  LDD1667  [8]
 LDCM0465  CL72 HEK-293T C303(1.05)  LDD1668  [8]
 LDCM0466  CL73 HEK-293T C303(1.12)  LDD1669  [8]
 LDCM0467  CL74 HEK-293T C303(0.93)  LDD1670  [8]
 LDCM0469  CL76 PaTu 8988t C237(0.73)  LDD1348  [7]
 LDCM0470  CL77 PaTu 8988t C237(0.59)  LDD1349  [7]
 LDCM0471  CL78 PaTu 8988t C237(0.55)  LDD1350  [7]
 LDCM0472  CL79 PaTu 8988t C237(0.92)  LDD1351  [7]
 LDCM0473  CL8 HEK-293T C303(1.46)  LDD1676  [8]
 LDCM0474  CL80 PaTu 8988t C237(0.55)  LDD1353  [7]
 LDCM0475  CL81 PaTu 8988t C237(0.51)  LDD1354  [7]
 LDCM0476  CL82 PaTu 8988t C237(0.73)  LDD1355  [7]
 LDCM0477  CL83 PaTu 8988t C237(0.56)  LDD1356  [7]
 LDCM0478  CL84 PaTu 8988t C237(0.49)  LDD1357  [7]
 LDCM0479  CL85 PaTu 8988t C237(0.84)  LDD1358  [7]
 LDCM0480  CL86 PaTu 8988t C237(0.50)  LDD1359  [7]
 LDCM0481  CL87 PaTu 8988t C237(0.43)  LDD1360  [7]
 LDCM0482  CL88 PaTu 8988t C237(0.47)  LDD1361  [7]
 LDCM0483  CL89 PaTu 8988t C237(0.41)  LDD1362  [7]
 LDCM0484  CL9 HEK-293T C303(0.91)  LDD1687  [8]
 LDCM0485  CL90 PaTu 8988t C237(0.52)  LDD1364  [7]
 LDCM0486  CL91 PaTu 8988t C237(0.32)  LDD1365  [7]
 LDCM0487  CL92 PaTu 8988t C237(0.31)  LDD1366  [7]
 LDCM0488  CL93 PaTu 8988t C237(0.25)  LDD1367  [7]
 LDCM0489  CL94 PaTu 8988t C237(0.30)  LDD1368  [7]
 LDCM0490  CL95 PaTu 8988t C237(0.26)  LDD1369  [7]
 LDCM0491  CL96 PaTu 8988t C237(0.24)  LDD1370  [7]
 LDCM0492  CL97 PaTu 8988t C237(0.25)  LDD1371  [7]
 LDCM0493  CL98 PaTu 8988t C237(0.22)  LDD1372  [7]
 LDCM0494  CL99 PaTu 8988t C237(0.36)  LDD1373  [7]
 LDCM0495  E2913 HEK-293T C303(1.05)  LDD1698  [8]
 LDCM0468  Fragment33 HEK-293T C303(1.03)  LDD1671  [8]
 LDCM0427  Fragment51 HEK-293T C303(0.91)  LDD1631  [8]
 LDCM0022  KB02 HEK-293T C303(0.97)  LDD1492  [8]
 LDCM0023  KB03 HEK-293T C303(1.01)  LDD1497  [8]
 LDCM0024  KB05 SK-MEL-28 C303(3.62)  LDD3427  [2]
 LDCM0509  N-(4-bromo-3,5-dimethylphenyl)-2-nitroacetamide MDA-MB-231 C303(0.78)  LDD2102  [3]
 LDCM0528  N-(4-bromophenyl)-2-cyano-N-phenylacetamide MDA-MB-231 C303(0.56)  LDD2121  [3]
 LDCM0496  Nucleophilic fragment 11a MDA-MB-231 C303(0.52)  LDD2089  [3]
 LDCM0499  Nucleophilic fragment 12b MDA-MB-231 C303(0.98)  LDD2092  [3]
 LDCM0501  Nucleophilic fragment 13b MDA-MB-231 C303(0.85)  LDD2094  [3]
 LDCM0504  Nucleophilic fragment 15a MDA-MB-231 C303(2.13)  LDD2097  [3]
 LDCM0505  Nucleophilic fragment 15b MDA-MB-231 C303(0.69)  LDD2098  [3]
 LDCM0506  Nucleophilic fragment 16a MDA-MB-231 C303(1.43)  LDD2099  [3]
 LDCM0514  Nucleophilic fragment 20a MDA-MB-231 C303(1.00)  LDD2107  [3]
 LDCM0515  Nucleophilic fragment 20b MDA-MB-231 C303(1.11)  LDD2108  [3]
 LDCM0518  Nucleophilic fragment 22a MDA-MB-231 C303(1.05)  LDD2111  [3]
 LDCM0522  Nucleophilic fragment 24a MDA-MB-231 C303(0.54)  LDD2115  [3]
 LDCM0526  Nucleophilic fragment 26a MDA-MB-231 C303(1.73)  LDD2119  [3]
 LDCM0527  Nucleophilic fragment 26b MDA-MB-231 C303(1.10)  LDD2120  [3]
 LDCM0532  Nucleophilic fragment 29a MDA-MB-231 C303(0.96)  LDD2125  [3]
 LDCM0534  Nucleophilic fragment 30a MDA-MB-231 C303(1.16)  LDD2127  [3]
 LDCM0535  Nucleophilic fragment 30b MDA-MB-231 C303(1.00)  LDD2128  [3]
 LDCM0541  Nucleophilic fragment 36 MDA-MB-231 C303(0.55)  LDD2134  [3]
 LDCM0542  Nucleophilic fragment 37 MDA-MB-231 C303(1.27)  LDD2135  [3]
 LDCM0544  Nucleophilic fragment 39 MDA-MB-231 C303(0.93)  LDD2137  [3]
 LDCM0211  Nucleophilic fragment 3b MDA-MB-231 C303(2.40)  LDD1700  [3]
 LDCM0546  Nucleophilic fragment 40 MDA-MB-231 C303(0.98)  LDD2140  [3]
 LDCM0549  Nucleophilic fragment 43 MDA-MB-231 C303(1.35)  LDD2143  [3]
 LDCM0550  Nucleophilic fragment 5a MDA-MB-231 C303(1.60)  LDD2144  [3]
 LDCM0552  Nucleophilic fragment 6a MDA-MB-231 C303(1.10)  LDD2146  [3]
 LDCM0554  Nucleophilic fragment 7a MDA-MB-231 C303(0.82)  LDD2148  [3]
 LDCM0556  Nucleophilic fragment 8a MDA-MB-231 C303(0.40)  LDD2150  [3]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Other
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Membrane protein BRI3 (BRI3) BRI3 family O95415

The Drug(s) Related To This Target

Investigative
Click To Hide/Show 1 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Uridine-diphosphate-n-acetylglucosamine Small molecular drug DB03397
Patented
Click To Hide/Show 9 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Us9586942, 16 Small molecular drug D0L5AE
Us9586942, 2 Small molecular drug D0A0ND
Us9586942, 3* Small molecular drug D0NT3V
Us9586945, 1 Small molecular drug D01OZO
Us9586945, 19a Small molecular drug D06WEY
Us9586945, 5 Small molecular drug D0Y6FF
Us9656955, Example 351 Small molecular drug D0V1PW
Us9656955, Example 540 Small molecular drug D0BJ3R
Us9656955, Example 652 Small molecular drug D01DYO

References

1 Ynamide Electrophile for the Profiling of Ligandable Carboxyl Residues in Live Cells and the Development of New Covalent Inhibitors. J Med Chem. 2022 Aug 11;65(15):10408-10418. doi: 10.1021/acs.jmedchem.2c00272. Epub 2022 Jul 26.
2 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
3 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
4 Targeted Proteomic Approaches for Proteome-Wide Characterizations of the AMP-Binding Capacities of Kinases. J Proteome Res. 2022 Aug 5;21(8):2063-2070. doi: 10.1021/acs.jproteome.2c00225. Epub 2022 Jul 12.
5 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
6 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
7 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
8 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402